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OPENSEQ.org
PDXA - 4-hydroxythreonine-4-phosphate dehydrogenase
UniProt: P19624 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10691
Length: 329 (324)
Sequences: 1352
Seq/Len: 4.17
PDXA
Paralog alert: 0.21 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
186_A 236_Q 4.747 1.00
170_R 174_D 4.582 1.00
220_T 224_D 3.974 1.00
144_S 290_F 3.711 1.00
8_V 113_F 3.099 1.00
167_L 175_A 3.077 1.00
189_H 193_R 2.771 1.00
37_C 107_G 2.719 1.00
108_C 113_F 2.663 1.00
40_A 77_P 2.571 1.00
178_P 232_E 2.418 1.00
148_K 183_E 2.411 1.00
116_L 140_F 2.395 1.00
85_T 88_Q 2.375 1.00
7_V 115_A 2.345 1.00
95_H 99_E 2.334 1.00
182_H 233_L 2.318 1.00
133_F 142_E 2.111 1.00
163_A 181_L 2.106 1.00
102_A 139_F 2.073 1.00
182_H 232_E 2.062 1.00
171_D 174_D 2.05 1.00
106_D 143_R 2.042 1.00
178_P 229_V 1.961 1.00
280_R 316_T 1.956 1.00
22_V 36_V 1.927 1.00
162_L 270_L 1.926 1.00
102_A 106_D 1.919 1.00
185_I 233_L 1.884 1.00
220_T 223_I 1.873 1.00
168_P 172_I 1.849 1.00
182_H 229_V 1.842 1.00
108_C 116_L 1.833 1.00
227_I 231_N 1.823 1.00
231_N 234_R 1.813 1.00
231_N 235_A 1.798 1.00
168_P 218_M 1.767 0.99
263_A 269_G 1.76 0.99
7_V 117_I 1.752 0.99
195_K 328_T 1.74 0.99
189_H 238_M 1.717 0.99
169_L 172_I 1.697 0.99
206_C 249_L 1.69 0.99
201_P 259_D 1.689 0.99
164_T 176_I 1.671 0.99
226_I 264_M 1.667 0.99
191_D 195_K 1.659 0.99
170_R 173_A 1.651 0.99
105_C 143_R 1.64 0.99
241_N 244_L 1.638 0.99
227_I 243_P 1.636 0.99
122_H 301_L 1.614 0.99
119_G 314_F 1.614 0.99
13_E 301_L 1.571 0.98
188_L 260_A 1.571 0.98
311_V 315_I 1.561 0.98
20_D 24_Q 1.533 0.98
161_A 188_L 1.526 0.98
107_G 113_F 1.487 0.98
101_L 121_V 1.483 0.98
200_E 239_K 1.479 0.98
252_P 258_A 1.46 0.97
21_L 314_F 1.441 0.97
229_V 238_M 1.397 0.96
202_R 259_D 1.397 0.96
124_G 215_G 1.385 0.96
177_T 225_T 1.382 0.96
104_A 116_L 1.364 0.95
151_M 283_N 1.356 0.95
23_V 54_L 1.333 0.95
249_L 261_V 1.331 0.95
23_V 50_L 1.328 0.95
293_T 321_A 1.318 0.94
273_L 281_G 1.311 0.94
102_A 143_R 1.293 0.93
163_A 264_M 1.292 0.93
185_I 262_L 1.289 0.93
188_L 262_L 1.285 0.93
164_T 172_I 1.281 0.93
9_I 314_F 1.28 0.93
229_V 233_L 1.274 0.93
155_T 277_G 1.266 0.92
105_C 139_F 1.265 0.92
222_E 227_I 1.254 0.92
154_A 320_L 1.251 0.92
182_H 186_A 1.232 0.91
205_V 226_I 1.228 0.91
20_D 306_R 1.223 0.91
137_T 292_R 1.218 0.90
42_L 80_L 1.218 0.90
271_P 275_Y 1.216 0.90
180_L 184_V 1.213 0.90
21_L 25_L 1.211 0.90
150_V 187_I 1.209 0.90
277_G 280_R 1.209 0.90
185_I 205_V 1.188 0.89
13_E 122_H 1.182 0.89
13_E 97_V 1.181 0.89
115_A 321_A 1.176 0.88
224_D 227_I 1.174 0.88
22_V 119_G 1.171 0.88
10_T 116_L 1.166 0.88
99_E 102_A 1.165 0.88
168_P 173_A 1.164 0.88
25_L 318_L 1.162 0.87
303_L 308_K 1.16 0.87
181_L 229_V 1.157 0.87
82_A 90_A 1.156 0.87
141_E 149_V 1.154 0.87
36_V 43_L 1.139 0.86
6_R 33_E 1.137 0.86
204_L 258_A 1.136 0.86
314_F 318_L 1.134 0.86
163_A 180_L 1.133 0.86
101_L 143_R 1.13 0.85
103_R 107_G 1.124 0.85
105_C 140_F 1.123 0.85
106_D 110_N 1.118 0.85
94_G 125_V 1.114 0.84
167_L 170_R 1.113 0.84
118_T 292_R 1.112 0.84
141_E 146_A 1.11 0.84
190_H 194_T 1.11 0.84
159_R 198_I 1.107 0.84
40_A 44_T 1.106 0.84
207_G 212_A 1.102 0.83
8_V 108_C 1.101 0.83
244_L 258_A 1.099 0.83
153_L 273_L 1.089 0.82
77_P 80_L 1.089 0.82
303_L 309_A 1.081 0.82
137_T 285_T 1.08 0.82
137_T 151_M 1.075 0.81
25_L 315_I 1.073 0.81
171_D 175_A 1.07 0.81
37_C 103_R 1.067 0.81
118_T 136_H 1.065 0.80
89_L 122_H 1.064 0.80
285_T 292_R 1.063 0.80
136_H 313_S 1.057 0.80
118_T 137_T 1.054 0.79
89_L 93_N 1.049 0.79
93_N 97_V 1.043 0.78
157_E 276_Q 1.033 0.78
202_R 241_N 1.031 0.77
38_A 96_Y 1.029 0.77
97_V 301_L 1.025 0.77
136_H 294_S 1.022 0.77
96_Y 100_T 1.021 0.76
149_V 187_I 1.02 0.76
186_A 238_M 1.014 0.76
279_G 310_D 1.013 0.76
76_L 107_G 1.011 0.75
159_R 260_A 1.005 0.75
178_P 182_H 1.004 0.75
246_A 249_L 1.004 0.75
181_L 264_M 1.003 0.75
40_A 58_P 1.001 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hi1A20.97871000.04Contact Map0.766
3tsnA40.97261000.086Contact Map0.674
4atyA10.98481000.23Contact Map0.726
1yxoA20.99391000.257Contact Map0.753
4jqpA20.99091000.258Contact Map0.766
3lxyA111000.259Contact Map0.704
1r5jA20.87541000.57Contact Map0.521
1td9A60.86931000.575Contact Map0.551
4e4rA10.86631000.579Contact Map0.543
1vmiA10.88151000.581Contact Map0.51
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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