OPENSEQ.org - PHNO - ECOLI GREMLIN

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PHNO - Protein PhnO

UniProt:	P16691	Sequence MPACELRPATQYDTDAVYALICELKQAEFDHHAFRVGFNANLRDPNMRYHLALLDGEVVGMIGLHLQFHLHHVNWIGEIQELVVMPQARGLNVGSKLLAWAEEEARQAGAEMTELSTNVKRHDAHRFYLREGYEQSHFRFTKAL	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10724
Length:	144 (136)
Sequences:	15196
Seq/Len:	111.74

PHNO
Paralog alert: 0.89 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
7_R	53_L	3.622	1.00
102_E	133_Y	2.697	1.00
23_E	85_M	2.648	1.00
95_S	131_E	2.566	1.00
62_I	101_A	2.466	1.00
7_R	13_D	2.427	1.00
100_W	103_E	2.271	1.00
52_A	93_V	2.249	1.00
95_S	130_R	2.206	1.00
50_H	100_W	2.143	1.00
59_V	88_A	2.138	1.00
125_H	129_L	2.107	1.00
51_L	58_V	2.08	1.00
129_L	135_Q	2.076	1.00
104_E	108_A	1.91	1.00
99_A	131_E	1.87	1.00
60_G	84_V	1.827	1.00
54_L	59_V	1.822	1.00
104_E	107_Q	1.799	1.00
9_A	17_V	1.769	1.00
88_A	91_L	1.767	1.00
98_L	131_E	1.693	1.00
115_L	128_Y	1.676	1.00
126_R	129_L	1.666	1.00
102_E	113_T	1.647	1.00
100_W	104_E	1.631	1.00
16_A	19_A	1.601	1.00
95_S	99_A	1.563	1.00
54_L	88_A	1.55	1.00
54_L	91_L	1.516	1.00
117_T	121_R	1.506	1.00
64_L	101_A	1.467	1.00
125_H	135_Q	1.464	1.00
49_Y	63_G	1.404	0.99
53_L	58_V	1.398	0.99
77_G	105_A	1.389	0.99
57_E	85_M	1.385	0.99
57_E	87_Q	1.352	0.99
16_A	58_V	1.334	0.99
50_H	104_E	1.31	0.99
77_G	110_A	1.294	0.99
53_L	56_G	1.293	0.99
19_A	23_E	1.253	0.99
5_E	53_L	1.246	0.98
122_H	126_R	1.245	0.98
62_I	97_L	1.226	0.98
92_N	95_S	1.211	0.98
84_V	93_V	1.202	0.98
16_A	20_L	1.178	0.98
85_M	88_A	1.172	0.98
103_E	107_Q	1.165	0.97
30_D	33_A	1.164	0.97
23_E	86_P	1.151	0.97
19_A	85_M	1.145	0.97
124_A	128_Y	1.142	0.97
89_R	123_D	1.128	0.97
66_L	110_A	1.127	0.97
8_P	48_R	1.126	0.97
117_T	125_H	1.121	0.97
31_H	35_R	1.118	0.96
21_I	61_M	1.117	0.96
122_H	125_H	1.102	0.96
48_R	108_A	1.1	0.96
96_K	100_W	1.087	0.96
8_P	104_E	1.085	0.96
59_V	93_V	1.078	0.95
105_A	113_T	1.075	0.95
18_Y	22_C	1.06	0.95
64_L	105_A	1.058	0.95
9_A	51_L	1.056	0.95
15_D	31_H	1.027	0.94
6_L	100_W	1.027	0.94
11_Q	39_N	1.025	0.93
103_E	106_R	1.018	0.93
117_T	124_A	1	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3fynA	1	0.9931	99.8	0.225	Contact Map	0.7
3t9yA	1	0.9931	99.8	0.228	Contact Map	0.71
4evyA	2	0.9861	99.8	0.234	Contact Map	0.702
3jvnA	1	0.9931	99.8	0.235	Contact Map	0.769
1vkcA	2	0.9931	99.8	0.247	Contact Map	0.626
1bo4A	2	0.9653	99.8	0.248	Contact Map	0.684
1s3zA	2	0.9931	99.8	0.25	Contact Map	0.742
1ufhA	2	0.9861	99.8	0.251	Contact Map	0.6
1z4eA	2	1	99.8	0.256	Contact Map	0.785
2j8mA	2	0.9792	99.8	0.259	Contact Map	0.726

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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