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OPENSEQ.org
FES - Enterochelin esterase
UniProt: P13039 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10299
Length: 374 (362)
Sequences: 464
Seq/Len: 1.28
FES
Paralog alert: 0.54 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FES YIEL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
237_K 242_F 3.233 1.00
45_I 48_T 3.028 1.00
265_G 275_V 2.642 1.00
314_E 357_G 2.631 1.00
327_Q 344_Q 2.374 0.99
245_R 248_R 2.217 0.99
166_E 199_P 2.162 0.99
158_F 190_T 2.026 0.97
206_I 232_L 2.011 0.97
65_Y 100_D 1.956 0.97
276_L 361_G 1.937 0.96
243_S 248_R 1.879 0.96
204_V 236_V 1.867 0.95
189_L 362_L 1.853 0.95
157_I 204_V 1.832 0.95
277_S 313_L 1.83 0.95
24_W 41_S 1.73 0.92
179_W 254_Q 1.672 0.91
158_F 193_T 1.659 0.90
134_A 191_S 1.631 0.89
206_I 319_E 1.612 0.88
259_L 319_E 1.605 0.88
279_S 354_W 1.586 0.87
157_I 202_V 1.554 0.86
341_F 364_D 1.538 0.85
332_Q 336_I 1.528 0.84
196_Q 199_P 1.507 0.83
334_H 340_I 1.499 0.83
132_P 195_R 1.496 0.83
179_W 252_A 1.488 0.82
173_L 252_A 1.487 0.82
246_A 273_G 1.479 0.82
146_S 231_E 1.476 0.81
4_V 118_L 1.471 0.81
327_Q 331_A 1.454 0.80
147_E 150_K 1.45 0.80
100_D 116_S 1.417 0.78
277_S 280_G 1.41 0.77
91_R 94_L 1.408 0.77
9_R 48_T 1.397 0.76
100_D 103_N 1.388 0.76
214_R 319_E 1.378 0.75
192_L 359_M 1.378 0.75
278_Q 361_G 1.369 0.74
315_A 322_I 1.364 0.74
265_G 309_L 1.352 0.73
188_V 191_S 1.352 0.73
25_V 267_H 1.348 0.73
173_L 185_V 1.347 0.72
8_W 69_P 1.339 0.72
171_A 365_L 1.336 0.72
10_D 13_G 1.329 0.71
173_L 179_W 1.322 0.70
146_S 149_L 1.32 0.70
330_Y 342_W 1.314 0.70
149_L 153_R 1.31 0.69
323_M 327_Q 1.309 0.69
306_A 338_E 1.305 0.69
144_W 231_E 1.299 0.68
262_L 280_G 1.295 0.68
353_C 357_G 1.289 0.68
202_V 236_V 1.289 0.68
280_G 326_N 1.287 0.67
172_V 249_T 1.285 0.67
323_M 329_L 1.285 0.67
331_A 335_P 1.274 0.66
173_L 358_L 1.273 0.66
171_A 252_A 1.266 0.66
175_D 254_Q 1.264 0.65
235_L 239_I 1.262 0.65
163_A 241_P 1.262 0.65
168_R 172_V 1.257 0.65
100_D 153_R 1.256 0.65
42_M 133_Q 1.255 0.65
22_R 41_S 1.251 0.64
347_G 353_C 1.247 0.64
192_L 365_L 1.233 0.63
254_Q 354_W 1.23 0.62
160_T 190_T 1.229 0.62
12_Q 303_E 1.228 0.62
168_R 202_V 1.226 0.62
345_V 353_C 1.223 0.62
231_E 280_G 1.221 0.61
342_W 355_R 1.218 0.61
196_Q 228_V 1.209 0.60
65_Y 358_L 1.209 0.60
256_F 281_S 1.208 0.60
42_M 56_Q 1.208 0.60
226_L 230_Q 1.206 0.60
330_Y 340_I 1.205 0.60
45_I 52_Q 1.2 0.59
42_M 150_K 1.183 0.58
47_G 301_A 1.183 0.58
350_D 356_G 1.181 0.58
67_F 162_D 1.179 0.57
133_Q 195_R 1.175 0.57
42_M 53_W 1.172 0.57
268_W 271_R 1.169 0.56
232_L 266_L 1.165 0.56
183_M 351_A 1.163 0.56
191_S 194_H 1.157 0.55
172_V 202_V 1.156 0.55
23_V 42_M 1.155 0.55
44_R 246_A 1.154 0.55
207_D 264_A 1.146 0.54
262_L 348_G 1.146 0.54
218_L 283_W 1.143 0.54
13_G 23_V 1.141 0.54
330_Y 334_H 1.141 0.54
11_P 23_V 1.14 0.54
169_P 172_V 1.139 0.54
60_N 346_D 1.138 0.53
154_R 342_W 1.129 0.53
64_S 117_A 1.129 0.53
72_R 88_E 1.128 0.52
255_S 349_H 1.128 0.52
189_L 251_V 1.127 0.52
206_I 228_V 1.124 0.52
192_L 312_V 1.119 0.52
161_G 184_P 1.116 0.51
5_T 54_T 1.111 0.51
15_E 222_A 1.11 0.51
175_D 361_G 1.109 0.51
233_L 242_F 1.108 0.50
280_G 350_D 1.107 0.50
180_A 205_L 1.105 0.50
228_V 264_A 1.103 0.50
158_F 249_T 1.099 0.50
281_S 284_W 1.098 0.49
273_G 329_L 1.096 0.49
47_G 238_A 1.095 0.49
269_P 308_G 1.094 0.49
262_L 265_G 1.092 0.49
97_A 284_W 1.092 0.49
61_W 179_W 1.092 0.49
75_I 78_V 1.091 0.49
279_S 355_R 1.088 0.48
25_V 55_T 1.085 0.48
154_R 313_L 1.082 0.48
51_W 258_G 1.081 0.48
63_G 319_E 1.079 0.48
348_G 353_C 1.073 0.47
280_G 284_W 1.071 0.47
126_Q 356_G 1.07 0.47
225_W 264_A 1.065 0.46
205_L 347_G 1.062 0.46
294_V 298_K 1.057 0.45
89_G 92_K 1.057 0.45
148_R 226_L 1.055 0.45
65_Y 103_N 1.055 0.45
178_F 182_S 1.053 0.45
354_W 361_G 1.046 0.44
172_V 237_K 1.044 0.44
148_R 231_E 1.042 0.44
254_Q 355_R 1.042 0.44
259_L 283_W 1.037 0.43
311_I 338_E 1.035 0.43
47_G 246_A 1.033 0.43
160_T 193_T 1.033 0.43
220_C 284_W 1.028 0.43
22_R 367_Q 1.028 0.43
167_E 242_F 1.027 0.42
108_K 182_S 1.022 0.42
263_Y 266_L 1.02 0.42
258_G 281_S 1.02 0.42
315_A 325_A 1.015 0.41
74_D 81_P 1.013 0.41
259_L 309_L 1.013 0.41
155_V 280_G 1.005 0.40
134_A 137_I 1.001 0.40
305_S 309_L 1 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c8dA411000.374Contact Map0.523
1jjfA10.68451000.68Contact Map0.583
1gklA20.71391000.71Contact Map0.492
3gffA20.62571000.712Contact Map0.505
4folA40.63641000.729Contact Map0.525
2gzsA10.62831000.733Contact Map0.458
2uz0A40.61761000.738Contact Map0.604
3ls2A40.62831000.738Contact Map0.59
2qm0A20.647199.90.749Contact Map0.479
3i6yA20.628399.90.754Contact Map0.546
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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