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OPENSEQ.org
RNH2 - Ribonuclease HII
UniProt: P10442 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10861
Length: 198 (186)
Sequences: 2183
Seq/Len: 11.74
RNH2
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_D 160_A 5.374 1.00
156_Q 177_H 3.942 1.00
150_L 182_H 2.784 1.00
58_Y 62_K 2.686 1.00
68_W 138_L 2.598 1.00
79_D 186_S 2.481 1.00
44_N 127_S 2.457 1.00
104_Y 120_M 2.415 1.00
28_V 72_R 2.336 1.00
158_G 169_F 2.27 1.00
159_F 162_H 2.164 1.00
125_G 132_I 2.162 1.00
55_L 145_A 2.154 1.00
69_S 97_G 2.151 1.00
58_Y 142_T 2.109 1.00
53_R 56_A 2.04 1.00
62_K 68_W 2.002 1.00
44_N 48_K 1.936 1.00
24_V 159_F 1.903 1.00
58_Y 145_A 1.887 1.00
84_L 110_N 1.86 1.00
172_E 176_E 1.853 1.00
58_Y 141_V 1.836 1.00
106_L 132_I 1.834 1.00
29_T 90_A 1.805 1.00
77_E 93_R 1.793 1.00
51_E 163_K 1.75 1.00
73_A 93_R 1.69 1.00
174_L 179_A 1.638 1.00
48_K 127_S 1.636 1.00
72_R 146_E 1.616 1.00
61_I 65_A 1.56 1.00
188_G 192_R 1.558 1.00
168_A 172_E 1.554 1.00
161_Q 169_F 1.546 1.00
169_F 173_K 1.544 1.00
23_L 171_L 1.511 1.00
151_D 156_Q 1.51 1.00
124_K 127_S 1.478 1.00
31_A 94_A 1.478 1.00
60_E 64_K 1.464 1.00
43_L 137_I 1.45 1.00
158_G 173_K 1.424 1.00
51_E 148_A 1.385 0.99
55_L 141_V 1.373 0.99
81_L 89_L 1.312 0.99
84_L 111_R 1.286 0.99
77_E 89_L 1.285 0.99
28_V 142_T 1.276 0.99
89_L 93_R 1.274 0.99
67_S 99_H 1.273 0.99
153_V 182_H 1.272 0.99
149_A 152_I 1.256 0.99
85_H 88_M 1.253 0.99
154_F 182_H 1.251 0.99
92_Q 96_A 1.244 0.98
122_V 132_I 1.237 0.98
26_A 146_E 1.218 0.98
29_T 87_T 1.218 0.98
82_N 87_T 1.214 0.98
78_I 83_I 1.212 0.98
66_L 100_I 1.211 0.98
74_E 77_E 1.204 0.98
62_K 138_L 1.193 0.98
112_C 121_A 1.193 0.98
159_F 182_H 1.19 0.98
35_D 38_R 1.183 0.98
13_A 102_P 1.165 0.97
43_L 133_S 1.163 0.97
43_L 134_A 1.161 0.97
27_V 83_I 1.145 0.97
18_V 141_V 1.142 0.97
55_L 148_A 1.139 0.97
105_V 117_M 1.132 0.97
162_H 173_K 1.131 0.97
56_A 60_E 1.121 0.97
73_A 77_E 1.109 0.96
112_C 119_A 1.102 0.96
179_A 185_R 1.101 0.96
159_F 180_T 1.088 0.96
49_L 57_L 1.084 0.96
43_L 130_P 1.082 0.96
18_V 162_H 1.075 0.95
24_V 147_M 1.073 0.95
88_M 111_R 1.073 0.95
42_G 53_R 1.063 0.95
172_E 175_A 1.063 0.95
13_A 33_I 1.052 0.95
104_Y 118_P 1.04 0.94
171_L 175_A 1.039 0.94
62_K 142_T 1.036 0.94
71_G 94_A 1.036 0.94
15_V 105_V 1.025 0.93
158_G 161_Q 1.025 0.93
142_T 145_A 1.019 0.93
72_R 142_T 1.015 0.93
169_F 172_E 1.01 0.93
129_V 133_S 1.006 0.93
73_A 89_L 1.004 0.93
124_K 128_R 1.002 0.92
51_E 55_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2etjA10.97471000.1Contact Map0.721
1uaxA20.93431000.187Contact Map0.679
1io2A10.93431000.193Contact Map0.641
3kioA10.97981000.195Contact Map0.436
1ekeA20.92931000.198Contact Map0.609
1i39A10.95961000.207Contact Map0.59
2d0bA10.96461000.254Contact Map0.323
3vn5A10.92421000.281Contact Map0.431
1s2xA10.27279.20.962Contact Map0
3tfgA20.54046.50.965Contact Map0.267
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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