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OPENSEQ.org

RNPH - Inactive ribonuclease PH
UniProt: P0CG19 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10863
Length: 228 (228)
Sequences: 2707
Seq/Len: 11.87

RNPH
Paralog alert: 0.69 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_S 10_Q 3.873 1.00
41_A 136_A 3.658 1.00
18_R 139_D 3.575 1.00
9_N 223_G 3.549 1.00
22_K 34_D 3.211 1.00
157_G 194_D 3.168 1.00
31_E 36_K 2.892 1.00
173_C 224_E 2.888 1.00
15_T 31_E 2.82 1.00
189_V 221_A 2.779 1.00
37_V 118_V 2.734 1.00
38_L 119_L 2.718 1.00
157_G 193_E 2.63 1.00
131_T 228_L 2.591 1.00
57_G 95_A 2.527 1.00
19_N 139_D 2.513 1.00
134_C 158_M 2.456 1.00
25_E 68_R 2.448 1.00
4_A 176_E 2.428 1.00
17_T 31_E 2.418 1.00
39_C 132_G 2.328 1.00
75_A 81_G 2.311 1.00
211_H 215_L 2.276 1.00
11_V 173_C 2.09 1.00
69_S 74_N 2.088 1.00
223_G 227_P 2.052 1.00
98_L 133_A 1.955 1.00
41_A 114_L 1.925 1.00
97_A 199_E 1.92 1.00
16_L 30_V 1.879 1.00
219_A 223_G 1.835 1.00
78_A 83_Q 1.797 1.00
3_P 178_V 1.731 1.00
75_A 80_K 1.718 1.00
162_V 173_C 1.708 1.00
141_L 145_V 1.691 1.00
165_G 175_L 1.686 1.00
210_T 213_E 1.684 1.00
21_T 40_T 1.683 1.00
166_I 213_E 1.651 1.00
8_N 170_E 1.647 1.00
67_P 76_R 1.629 1.00
211_H 222_R 1.562 1.00
106_A 152_T 1.547 1.00
145_V 153_N 1.529 1.00
14_V 228_L 1.471 1.00
143_K 147_N 1.455 1.00
84_G 88_M 1.451 1.00
160_A 225_S 1.411 1.00
3_P 176_E 1.405 0.99
74_N 81_G 1.401 0.99
16_L 135_V 1.356 0.99
41_A 140_A 1.355 0.99
145_V 150_L 1.35 0.99
102_V 137_L 1.316 0.99
46_G 111_T 1.308 0.99
101_A 157_G 1.289 0.99
101_A 159_V 1.286 0.99
168_N 206_G 1.279 0.99
134_C 138_V 1.247 0.99
102_V 112_I 1.246 0.98
107_L 154_P 1.235 0.98
56_Q 105_K 1.232 0.98
51_L 56_Q 1.232 0.98
64_G 83_Q 1.224 0.98
215_L 219_A 1.222 0.98
222_R 226_N 1.188 0.98
157_G 192_T 1.182 0.98
212_E 216_I 1.175 0.98
57_G 92_R 1.166 0.97
76_R 81_G 1.164 0.97
107_L 141_L 1.163 0.97
171_A 220_L 1.158 0.97
74_N 84_G 1.158 0.97
112_I 141_L 1.155 0.97
219_A 222_R 1.152 0.97
189_V 218_L 1.148 0.97
158_M 193_E 1.125 0.97
95_A 99_R 1.117 0.96
46_G 49_R 1.116 0.96
138_V 155_M 1.114 0.96
4_A 167_V 1.111 0.96
77_E 84_G 1.109 0.96
15_T 29_L 1.1 0.96
141_L 153_N 1.099 0.96
144_L 149_K 1.08 0.95
215_L 222_R 1.072 0.95
40_T 117_D 1.068 0.95
43_I 144_L 1.066 0.95
39_C 114_L 1.056 0.95
192_T 198_I 1.053 0.95
127_T 130_I 1.045 0.94
192_T 196_R 1.043 0.94
114_L 137_L 1.043 0.94
164_V 171_A 1.036 0.94
49_R 110_F 1.034 0.94
21_T 24_A 1.033 0.94
212_E 215_L 1.032 0.94
77_E 87_T 1.023 0.93
29_L 36_K 1.004 0.93
211_H 219_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1udnA111000.131Contact Map0.707
3dd6A111000.134Contact Map0.7
1oysA111000.138Contact Map0.76
3b4tA611000.144Contact Map0.737
1r6lA111000.157Contact Map0.738
2po1B10.96931000.165Contact Map0.711
3m7nD30.91671000.165Contact Map0.736
2je6B10.91671000.169Contact Map0.729
3m7nG30.96931000.17Contact Map0.683
2wnrB30.91671000.171Contact Map0.68

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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