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OPENSEQ.org
SECY - Protein translocase subunit SecY
UniProt: P0AGA2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10766
Length: 443 (429)
Sequences: 1698
Seq/Len: 3.96
SECY
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
360_E 364_K 3.781 1.00
36_G 78_F 3.608 1.00
322_A 382_T 3.555 1.00
330_F 375_L 3.254 1.00
92_I 116_I 3.246 1.00
29_A 174_L 3.201 1.00
140_P 157_Y 3.154 1.00
110_E 113_R 2.821 1.00
24_L 28_G 2.758 1.00
343_A 363_A 2.618 1.00
326_I 382_T 2.526 1.00
105_I 119_Y 2.505 1.00
25_F 29_A 2.488 1.00
367_D 371_T 2.388 1.00
39_I 77_I 2.219 1.00
316_L 319_L 2.189 1.00
132_S 165_V 2.183 1.00
32_V 170_F 2.142 1.00
267_L 370_M 2.098 1.00
322_A 326_I 2.029 1.00
102_L 116_I 2.02 1.00
329_C 381_I 1.962 1.00
170_F 174_L 1.936 1.00
18_E 21_R 1.88 1.00
65_N 73_S 1.835 1.00
124_T 168_T 1.812 1.00
277_A 385_C 1.808 1.00
246_V 265_L 1.807 1.00
92_I 102_L 1.805 1.00
26_V 189_I 1.764 0.99
115_K 118_Q 1.733 0.99
238_E 380_Y 1.721 0.99
233_F 383_F 1.697 0.99
129_I 165_V 1.676 0.99
221_L 225_V 1.651 0.99
248_Y 351_A 1.64 0.99
125_L 169_M 1.623 0.99
101_T 104_E 1.618 0.99
30_L 193_A 1.596 0.98
339_P 367_D 1.593 0.98
344_D 347_K 1.592 0.98
253_Q 260_A 1.583 0.98
305_T 309_Y 1.582 0.98
92_I 123_G 1.579 0.98
437_N 440_G 1.555 0.98
23_L 27_I 1.543 0.98
154_F 158_F 1.543 0.98
326_I 378_A 1.513 0.98
240_G 269_V 1.513 0.98
33_F 194_G 1.505 0.98
283_I 324_A 1.477 0.97
169_M 172_M 1.468 0.97
239_R 414_M 1.463 0.97
96_T 116_I 1.437 0.97
30_L 189_I 1.426 0.96
168_T 171_L 1.421 0.96
250_K 259_A 1.421 0.96
51_K 54_E 1.418 0.96
302_W 310_L 1.418 0.96
208_E 211_R 1.416 0.96
267_L 373_L 1.414 0.96
32_V 174_L 1.395 0.96
33_F 37_S 1.379 0.95
16_L 424_M 1.377 0.95
233_F 237_V 1.373 0.95
368_K 372_R 1.361 0.95
237_V 380_Y 1.349 0.95
238_E 268_K 1.34 0.94
154_F 157_Y 1.339 0.94
315_P 319_L 1.331 0.94
359_G 362_T 1.33 0.94
51_K 55_Q 1.321 0.94
344_D 348_K 1.316 0.94
17_G 21_R 1.316 0.94
159_T 326_I 1.299 0.93
379_L 383_F 1.293 0.93
80_L 87_S 1.292 0.93
10_Q 13_K 1.29 0.93
256_R 260_A 1.284 0.92
31_I 35_I 1.281 0.92
421_Q 432_A 1.261 0.92
341_E 345_N 1.258 0.91
289_T 293_W 1.252 0.91
50_A 54_E 1.251 0.91
129_I 296_G 1.245 0.91
103_A 107_K 1.235 0.90
110_E 114_R 1.235 0.90
210_A 220_L 1.227 0.90
83_M 87_S 1.227 0.90
361_Q 364_K 1.227 0.90
118_Q 122_Y 1.226 0.90
128_A 165_V 1.224 0.90
87_S 277_A 1.22 0.90
37_S 71_A 1.218 0.90
41_I 160_A 1.218 0.90
424_M 427_S 1.209 0.89
127_L 432_A 1.201 0.89
48_V 51_K 1.2 0.89
95_L 440_G 1.2 0.89
172_M 176_E 1.199 0.89
334_A 367_D 1.198 0.89
129_I 161_V 1.195 0.88
121_R 176_E 1.194 0.88
415_D 419_Q 1.181 0.88
96_T 106_K 1.178 0.87
29_A 170_F 1.178 0.87
102_L 105_I 1.17 0.87
326_I 379_L 1.169 0.87
434_K 437_N 1.165 0.87
345_N 349_S 1.165 0.87
183_I 416_F 1.164 0.87
274_V 403_G 1.16 0.86
156_F 160_A 1.158 0.86
358_P 362_T 1.156 0.86
319_L 323_S 1.153 0.86
265_L 428_Q 1.152 0.86
209_Q 214_D 1.15 0.86
128_A 168_T 1.147 0.86
230_V 234_V 1.145 0.85
129_I 132_S 1.144 0.85
271_M 370_M 1.144 0.85
253_Q 256_R 1.137 0.85
210_A 215_L 1.137 0.85
203_I 207_I 1.136 0.85
100_P 103_A 1.132 0.84
47_A 50_A 1.131 0.84
312_P 317_Y 1.129 0.84
315_P 318_V 1.128 0.84
123_G 187_I 1.125 0.84
45_D 48_V 1.124 0.84
306_I 309_Y 1.12 0.84
28_G 31_I 1.114 0.83
201_P 369_V 1.114 0.83
230_V 387_I 1.114 0.83
226_L 291_A 1.098 0.82
171_L 190_I 1.097 0.82
101_T 105_I 1.097 0.82
253_Q 259_A 1.095 0.82
235_V 271_M 1.094 0.82
340_R 363_A 1.09 0.81
88_A 123_G 1.089 0.81
132_S 136_A 1.086 0.81
130_F 137_T 1.081 0.81
189_I 416_F 1.081 0.81
189_I 384_I 1.077 0.80
286_F 290_I 1.076 0.80
19_L 183_I 1.072 0.80
379_L 385_C 1.071 0.80
323_S 327_F 1.07 0.80
17_G 41_I 1.068 0.79
26_V 182_G 1.068 0.79
255_R 260_A 1.062 0.79
288_A 291_A 1.06 0.79
73_S 76_S 1.059 0.79
408_I 412_V 1.058 0.79
335_L 351_A 1.056 0.78
243_R 304_T 1.051 0.78
117_S 344_D 1.051 0.78
243_R 264_H 1.045 0.77
202_A 378_A 1.045 0.77
63_M 67_F 1.044 0.77
121_R 172_M 1.042 0.77
96_T 265_L 1.041 0.77
235_V 349_S 1.04 0.77
237_V 265_L 1.038 0.77
221_L 290_I 1.037 0.77
31_I 233_F 1.034 0.76
104_E 108_E 1.033 0.76
189_I 193_A 1.03 0.76
54_E 434_K 1.029 0.76
99_H 103_A 1.028 0.76
161_V 165_V 1.028 0.76
21_R 24_L 1.023 0.75
224_A 228_F 1.021 0.75
306_I 310_L 1.021 0.75
393_D 396_K 1.02 0.75
220_L 223_V 1.019 0.75
127_L 275_I 1.015 0.74
183_I 193_A 1.014 0.74
329_C 378_A 1.014 0.74
22_R 269_V 1.005 0.73
342_T 366_I 1.003 0.73
239_R 418_A 1.003 0.73
92_I 275_I 1 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3j01A10.98191000.072Contact Map0.193
2zjsY10.96841000.091Contact Map0.544
3dinC20.95941000.095Contact Map0.298
3dl8G20.96161000.095Contact Map0.021
1rh5A10.90071000.178Contact Map0.528
3mp7A10.9211000.18Contact Map0.462
2ww9A10.91871000.211Contact Map0.392
2wwbA10.89621000.26Contact Map0.398
3ar4A10.28443.30.982Contact Map0.454
1svfB20.08351.90.985Contact Map0.179
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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