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OPENSEQ.org
PSTS - Phosphate-binding protein PstS
UniProt: P0AG82 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10734
Length: 346 (315)
Sequences: 1508
Seq/Len: 4.79
PSTS
Paralog alert: 0.19 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_D 152_S 3.94 1.00
121_D 124_T 3.649 1.00
153_Q 214_G 3.523 1.00
34_A 37_P 3.289 1.00
121_D 144_L 3.246 1.00
61_I 65_G 3.184 1.00
124_T 145_N 3.096 1.00
135_K 152_S 2.912 1.00
119_V 241_P 2.841 1.00
35_T 60_G 2.791 1.00
120_L 232_T 2.677 1.00
169_V 279_S 2.6 1.00
135_K 154_N 2.443 1.00
137_D 142_A 2.426 1.00
233_K 243_S 2.379 1.00
145_N 149_K 2.347 1.00
127_D 132_K 2.342 1.00
60_G 203_D 2.326 1.00
107_A 209_V 2.285 1.00
128_I 155_I 2.255 1.00
86_D 90_A 2.225 1.00
106_L 125_L 2.198 1.00
63_S 80_S 2.127 1.00
32_A 69_Q 2.075 1.00
323_D 327_E 2.045 1.00
303_D 330_R 1.95 1.00
126_G 178_N 1.947 1.00
124_T 144_L 1.889 1.00
111_P 213_P 1.87 1.00
245_T 248_N 1.859 1.00
142_A 147_G 1.841 1.00
31_G 77_F 1.834 1.00
121_D 235_I 1.832 1.00
124_T 127_D 1.732 1.00
123_K 127_D 1.732 1.00
119_V 233_K 1.719 1.00
240_K 273_D 1.717 1.00
48_Y 300_K 1.71 0.99
237_A 268_N 1.698 0.99
37_P 41_Y 1.671 0.99
38_A 60_G 1.639 0.99
32_A 75_V 1.598 0.99
157_V 216_I 1.584 0.99
129_Y 157_V 1.568 0.99
108_V 232_T 1.568 0.99
98_P 329_V 1.559 0.99
80_S 284_L 1.554 0.99
32_A 61_I 1.545 0.99
327_E 331_A 1.525 0.99
104_V 279_S 1.519 0.99
37_P 283_I 1.503 0.98
76_D 294_Q 1.488 0.98
100_V 281_T 1.463 0.98
40_V 100_V 1.452 0.98
310_A 326_V 1.445 0.98
327_E 330_R 1.44 0.98
240_K 272_E 1.439 0.98
107_A 219_V 1.436 0.98
48_Y 54_N 1.434 0.98
120_L 125_L 1.426 0.98
95_F 287_K 1.423 0.97
235_I 241_P 1.418 0.97
64_S 163_G 1.414 0.97
34_A 283_I 1.403 0.97
106_L 170_F 1.401 0.97
104_V 169_V 1.393 0.97
41_Y 305_A 1.376 0.97
34_A 41_Y 1.374 0.97
271_G 274_A 1.372 0.97
127_D 140_A 1.371 0.97
134_K 138_D 1.359 0.96
236_S 239_G 1.359 0.96
120_L 128_I 1.351 0.96
266_L 269_Q 1.348 0.96
291_K 294_Q 1.348 0.96
149_K 228_N 1.326 0.96
86_D 263_A 1.323 0.96
41_Y 301_F 1.32 0.96
120_L 234_L 1.32 0.96
36_F 102_G 1.311 0.95
132_K 135_K 1.311 0.95
296_T 300_K 1.309 0.95
89_L 94_L 1.291 0.95
67_V 84_L 1.285 0.95
85_S 88_K 1.276 0.94
153_Q 213_P 1.271 0.94
176_K 267_T 1.271 0.94
326_V 330_R 1.269 0.94
99_T 281_T 1.264 0.94
51_E 308_T 1.26 0.94
114_K 117_E 1.244 0.93
45_A 301_F 1.237 0.93
101_I 253_A 1.215 0.92
111_P 214_G 1.212 0.92
130_L 185_V 1.211 0.92
41_Y 99_T 1.21 0.92
103_G 249_F 1.208 0.92
167_S 218_Y 1.207 0.92
250_A 319_A 1.206 0.92
156_A 212_L 1.201 0.92
98_P 325_V 1.197 0.92
208_F 212_L 1.182 0.91
289_Q 295_G 1.18 0.91
41_Y 281_T 1.173 0.90
146_P 149_K 1.162 0.90
133_I 138_D 1.155 0.89
139_E 143_K 1.152 0.89
59_Q 69_Q 1.147 0.89
222_A 318_Y 1.144 0.89
47_T 50_K 1.143 0.89
246_E 250_A 1.138 0.89
73_N 286_H 1.132 0.88
224_A 231_Y 1.126 0.88
132_K 180_E 1.123 0.88
306_Y 333_W 1.119 0.87
220_E 223_Y 1.115 0.87
328_Q 331_A 1.114 0.87
30_T 57_N 1.109 0.87
300_K 303_D 1.107 0.87
82_A 168_F 1.105 0.87
302_F 333_W 1.101 0.86
285_I 302_F 1.101 0.86
48_Y 304_W 1.099 0.86
331_A 334_K 1.094 0.86
330_R 334_K 1.079 0.85
180_E 184_N 1.071 0.84
110_I 214_G 1.067 0.84
82_A 88_K 1.062 0.83
122_G 144_L 1.055 0.83
67_V 88_K 1.044 0.82
134_K 152_S 1.042 0.82
122_G 173_Y 1.041 0.82
329_V 332_A 1.04 0.82
69_Q 75_V 1.04 0.82
44_W 309_G 1.037 0.81
262_F 332_A 1.035 0.81
209_V 217_G 1.034 0.81
70_I 94_L 1.033 0.81
307_K 330_R 1.032 0.81
83_P 96_Q 1.027 0.81
86_D 89_L 1.025 0.80
135_K 153_Q 1.025 0.80
135_K 150_L 1.024 0.80
102_G 220_E 1.021 0.80
130_L 180_E 1.014 0.79
243_S 323_D 1.011 0.79
57_N 69_Q 1.007 0.79
47_T 312_Q 1.003 0.78
159_R 193_W 1.002 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3g63A10.88731000.357Contact Map0.555
1ixhA10.92491000.516Contact Map0.754
1pc3A20.95091000.567Contact Map0.693
4jwoA10.849799.90.714Contact Map0.69
4gd5A20.768899.90.724Contact Map0.833
1twyA80.823799.90.759Contact Map0.794
4exlA40.751499.80.773Contact Map0.731
4ecfA10.748699.80.784Contact Map0.754
3cg1A20.760199.70.803Contact Map0.506
4h1xA10.468299.70.805Contact Map0.708
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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