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OPENSEQ.org
TQSA - AI-2 transport protein TqsA
UniProt: P0AFS5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13928
Length: 344 (321)
Sequences: 4831
Seq/Len: 15.05
TQSA
Paralog alert: 0.78 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: PERM TQSA YDIK YHHT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
214_M 267_G 4.453 1.00
212_W 227_G 4.397 1.00
53_H 57_W 3.763 1.00
262_L 266_A 2.826 1.00
55_V 61_R 2.688 1.00
212_W 216_A 2.51 1.00
45_V 190_I 2.5 1.00
208_G 231_F 2.451 1.00
208_G 227_G 2.43 1.00
60_P 63_L 2.416 1.00
298_S 318_T 2.342 1.00
249_I 265_L 2.326 1.00
59_V 67_I 2.273 1.00
215_L 220_V 2.249 1.00
159_L 163_L 2.224 1.00
213_A 216_A 2.223 1.00
43_I 158_V 2.219 1.00
53_H 56_R 2.165 1.00
322_K 326_E 2.137 1.00
40_A 158_V 2.134 1.00
259_Y 263_L 2.131 1.00
249_I 261_A 2.085 1.00
266_A 270_L 2.004 1.00
201_T 235_Y 1.927 1.00
157_T 293_L 1.882 1.00
199_L 283_I 1.835 1.00
211_A 271_I 1.819 1.00
157_T 161_M 1.817 1.00
216_A 223_A 1.814 1.00
164_E 291_S 1.808 1.00
211_A 230_A 1.802 1.00
263_L 266_A 1.761 1.00
282_R 286_R 1.718 1.00
47_L 162_L 1.71 1.00
279_L 283_I 1.686 1.00
93_T 96_Q 1.682 1.00
99_N 102_M 1.645 1.00
207_T 234_N 1.637 1.00
51_V 65_V 1.618 1.00
51_V 68_L 1.616 1.00
259_Y 262_L 1.611 1.00
260_E 263_L 1.61 1.00
65_V 159_L 1.609 1.00
210_V 271_I 1.56 1.00
48_N 61_R 1.553 1.00
221_R 255_F 1.552 1.00
62_V 66_S 1.545 1.00
212_W 223_A 1.545 1.00
123_Q 126_H 1.53 1.00
203_I 275_F 1.517 1.00
48_N 52_Q 1.513 1.00
303_G 311_M 1.504 1.00
272_N 276_G 1.504 1.00
223_A 227_G 1.499 1.00
102_M 106_Q 1.498 1.00
62_V 163_L 1.491 1.00
51_V 61_R 1.491 1.00
229_L 233_L 1.472 1.00
213_A 217_A 1.471 1.00
269_L 273_L 1.461 1.00
37_F 297_L 1.454 1.00
252_V 264_V 1.424 1.00
95_P 99_N 1.413 1.00
253_L 261_A 1.399 0.99
226_W 248_P 1.395 0.99
59_V 64_A 1.395 0.99
233_L 244_A 1.386 0.99
41_L 161_M 1.376 0.99
50_L 68_L 1.366 0.99
229_L 244_A 1.36 0.99
50_L 53_H 1.352 0.99
252_V 261_A 1.343 0.99
188_R 327_Q 1.33 0.99
62_V 159_L 1.328 0.99
170_G 174_Q 1.327 0.99
96_Q 99_N 1.318 0.99
218_L 267_G 1.316 0.99
309_V 313_L 1.31 0.99
40_A 44_A 1.305 0.99
154_L 158_V 1.281 0.99
167_Q 170_G 1.278 0.99
37_F 157_T 1.272 0.99
299_L 311_M 1.245 0.98
36_P 285_G 1.244 0.98
276_G 280_E 1.243 0.98
297_L 301_F 1.241 0.98
274_V 278_I 1.239 0.98
214_M 218_L 1.238 0.98
204_S 234_N 1.237 0.98
36_P 40_A 1.236 0.98
208_G 212_W 1.231 0.98
177_A 180_V 1.212 0.98
227_G 231_F 1.212 0.98
207_T 271_I 1.209 0.98
290_L 318_T 1.206 0.98
51_V 162_L 1.2 0.98
47_L 72_I 1.197 0.98
54_M 71_I 1.196 0.98
257_G 260_E 1.192 0.98
203_I 234_N 1.188 0.98
140_L 144_L 1.184 0.98
234_N 241_S 1.176 0.98
55_V 64_A 1.176 0.98
147_A 151_I 1.175 0.98
218_L 264_V 1.153 0.97
214_M 271_I 1.151 0.97
302_W 318_T 1.15 0.97
100_S 103_T 1.149 0.97
275_F 280_E 1.148 0.97
258_F 261_A 1.144 0.97
227_G 230_A 1.14 0.97
231_F 235_Y 1.135 0.97
189_A 320_I 1.135 0.97
263_L 267_G 1.132 0.97
273_L 277_N 1.132 0.97
122_D 125_A 1.13 0.97
207_T 280_E 1.129 0.97
61_R 166_P 1.127 0.97
212_W 224_F 1.125 0.97
207_T 211_A 1.116 0.96
48_N 165_V 1.116 0.96
195_H 199_L 1.116 0.96
65_V 69_M 1.109 0.96
203_I 280_E 1.108 0.96
157_T 297_L 1.105 0.96
215_L 226_W 1.104 0.96
222_F 225_V 1.1 0.96
40_A 154_L 1.096 0.96
52_Q 56_R 1.089 0.96
270_L 274_V 1.089 0.96
111_L 114_R 1.089 0.96
73_V 77_V 1.082 0.96
201_T 205_I 1.078 0.95
26_G 30_A 1.076 0.95
207_T 241_S 1.073 0.95
245_A 249_I 1.07 0.95
302_W 317_L 1.07 0.95
44_A 158_V 1.065 0.95
226_W 251_Q 1.064 0.95
44_A 161_M 1.062 0.95
274_V 279_L 1.061 0.95
18_G 22_I 1.059 0.95
200_K 280_E 1.058 0.95
51_V 64_A 1.05 0.94
66_S 70_T 1.05 0.94
91_T 95_P 1.039 0.94
195_H 287_G 1.038 0.94
298_S 302_W 1.035 0.94
88_N 92_R 1.03 0.94
215_L 264_V 1.02 0.93
261_A 265_L 1.018 0.93
202_A 283_I 1.018 0.93
133_A 136_L 1.017 0.93
13_I 17_L 1.011 0.93
89_E 92_R 1.009 0.93
165_V 169_P 1.004 0.93
302_W 306_L 1.004 0.93
203_I 207_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
3b4rA20.200614.50.958Contact Map0.348
3ne5A10.18022.40.971Contact Map0.352
1j2jB10.06692.30.971Contact Map
2kv5A10.09592.30.971Contact Map0.303
4h44A10.52332.10.972Contact Map0.237
2lk9A10.10171.50.974Contact Map0.046
3ci9A20.12791.50.974Contact Map0.842
4g1uA20.1861.40.975Contact Map0.491
2m8rA10.11051.30.975Contact Map0.185
3hd7B20.11051.30.975Contact Map0.229
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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