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OPENSEQ.org
PERM - Putative permease PerM
UniProt: P0AFI9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14221
Length: 353 (333)
Sequences: 4823
Seq/Len: 14.48
PERM
Paralog alert: 0.79 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: PERM TQSA YDIK YHHT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
230_G 284_V 4.608 1.00
228_W 243_A 4.56 1.00
58_R 62_I 3.697 1.00
279_W 283_A 2.911 1.00
50_Y 206_N 2.882 1.00
60_Q 66_R 2.827 1.00
224_G 243_A 2.665 1.00
315_S 335_A 2.661 1.00
224_G 247_G 2.463 1.00
228_W 232_L 2.443 1.00
265_V 282_F 2.383 1.00
65_S 68_W 2.365 1.00
231_F 236_L 2.355 1.00
64_C 72_I 2.303 1.00
48_L 173_V 2.28 1.00
174_F 178_K 2.279 1.00
339_K 343_H 2.215 1.00
58_R 61_S 2.194 1.00
45_A 173_V 2.158 1.00
265_V 278_F 2.141 1.00
229_L 232_L 2.093 1.00
217_V 251_L 2.007 1.00
172_M 310_L 1.953 1.00
276_T 280_S 1.952 1.00
215_G 300_L 1.932 1.00
172_M 176_L 1.888 1.00
227_T 246_V 1.871 1.00
296_L 300_L 1.87 1.00
179_D 308_H 1.835 1.00
227_T 288_I 1.802 1.00
283_A 287_I 1.75 1.00
232_L 239_S 1.736 1.00
52_L 177_L 1.733 1.00
129_I 132_A 1.732 1.00
299_V 303_E 1.721 1.00
70_T 174_F 1.702 1.00
280_S 283_A 1.701 1.00
56_T 70_T 1.697 1.00
102_D 105_G 1.657 1.00
56_T 73_V 1.646 1.00
223_V 250_V 1.604 1.00
67_R 71_S 1.594 1.00
226_A 288_I 1.591 1.00
229_L 233_L 1.578 1.00
268_A 281_C 1.574 1.00
53_E 66_R 1.555 1.00
228_W 239_S 1.554 1.00
239_S 243_A 1.532 1.00
67_R 178_K 1.531 1.00
320_G 328_V 1.527 1.00
53_E 57_V 1.524 1.00
289_Q 293_G 1.51 1.00
56_T 66_R 1.499 1.00
108_N 111_S 1.473 1.00
276_T 279_W 1.466 1.00
237_N 271_Q 1.447 1.00
277_E 280_S 1.444 1.00
55_P 58_R 1.443 1.00
219_E 292_D 1.44 1.00
42_L 314_L 1.437 1.00
59_L 76_V 1.434 1.00
105_G 108_N 1.415 1.00
249_S 260_V 1.403 0.99
205_M 337_L 1.401 0.99
45_A 49_A 1.394 0.99
200_Q 344_A 1.393 0.99
67_R 174_F 1.388 0.99
242_L 264_V 1.383 0.99
245_L 249_S 1.368 0.99
46_I 176_L 1.361 0.99
169_V 173_V 1.351 0.99
234_F 284_V 1.35 0.99
245_L 260_V 1.349 0.99
55_P 73_V 1.348 0.99
286_L 290_A 1.347 0.99
191_L 198_A 1.346 0.99
230_G 234_F 1.332 0.99
204_E 344_A 1.31 0.99
326_W 330_F 1.31 0.99
230_G 288_I 1.303 0.99
243_A 247_G 1.299 0.99
250_V 257_A 1.28 0.99
185_N 189_R 1.27 0.99
268_A 278_F 1.257 0.99
78_V 82_L 1.255 0.99
64_C 69_A 1.244 0.98
41_P 45_A 1.234 0.98
269_L 278_F 1.224 0.98
219_E 250_V 1.223 0.98
220_M 250_V 1.221 0.98
188_R 199_G 1.22 0.98
52_L 77_F 1.219 0.98
42_L 172_M 1.208 0.98
319_F 335_A 1.207 0.98
70_T 74_L 1.206 0.98
66_R 181_E 1.206 0.98
224_G 228_W 1.201 0.98
314_L 318_I 1.196 0.98
109_K 112_D 1.193 0.98
223_V 297_V 1.192 0.98
104_P 108_N 1.186 0.98
56_T 177_L 1.185 0.98
41_P 302_S 1.181 0.98
293_G 297_V 1.178 0.98
316_V 328_V 1.177 0.98
223_V 288_I 1.176 0.98
231_F 242_L 1.162 0.97
228_W 240_L 1.16 0.97
243_A 246_V 1.157 0.97
307_L 335_A 1.157 0.97
82_L 86_F 1.155 0.97
238_Y 241_L 1.153 0.97
290_A 294_N 1.151 0.97
182_Q 185_N 1.144 0.97
149_V 153_L 1.143 0.97
291_L 296_L 1.143 0.97
136_N 139_S 1.13 0.97
45_A 169_V 1.13 0.97
247_G 251_L 1.129 0.97
261_T 265_V 1.129 0.97
97_I 101_R 1.126 0.97
60_Q 69_A 1.123 0.97
292_D 297_V 1.121 0.97
275_G 278_F 1.111 0.96
192_P 195_R 1.111 0.96
53_E 180_K 1.108 0.96
128_G 131_D 1.107 0.96
140_R 143_T 1.103 0.96
219_E 297_V 1.103 0.96
287_I 291_L 1.102 0.96
208_Q 336_T 1.1 0.96
155_S 159_L 1.1 0.96
223_V 257_A 1.099 0.96
132_A 135_E 1.099 0.96
49_A 176_L 1.095 0.96
234_F 281_C 1.093 0.96
211_N 215_G 1.089 0.96
111_S 115_A 1.088 0.96
223_V 227_T 1.087 0.96
180_K 184_L 1.076 0.95
162_I 166_L 1.067 0.95
217_V 221_I 1.066 0.95
315_S 319_F 1.065 0.95
230_G 280_S 1.061 0.95
172_M 314_L 1.061 0.95
216_K 297_V 1.059 0.95
219_E 223_V 1.058 0.95
56_T 69_A 1.055 0.95
284_V 288_I 1.053 0.95
219_E 301_F 1.05 0.94
57_V 61_S 1.049 0.94
250_V 297_V 1.046 0.94
49_A 173_V 1.041 0.94
311_V 335_A 1.041 0.94
179_D 182_Q 1.038 0.94
185_N 199_G 1.032 0.94
112_D 115_A 1.031 0.94
316_V 321_G 1.03 0.94
52_L 73_V 1.026 0.94
211_N 304_A 1.025 0.93
231_F 281_C 1.018 0.93
242_L 267_V 1.016 0.93
291_L 295_L 1.012 0.93
218_L 300_L 1.011 0.93
71_S 75_V 1.006 0.93
331_A 335_A 1.003 0.93
280_S 284_V 1.002 0.92
134_A 137_M 1.001 0.92
89_L 93_W 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2kv5A10.090710.40.963Contact Map0
4b19A10.0856.80.966Contact Map0.247
3hzqA10.2553.70.97Contact Map0.269
3b4rA20.17282.50.972Contact Map0.294
1rrzA10.0852.10.973Contact Map
3bo0B10.184120.974Contact Map0.207
3ixzA10.22661.90.974Contact Map0.062
3vouA20.35691.80.974Contact Map0.564
3ar4A10.21531.80.974Contact Map0.201
4g3oA10.15011.70.975Contact Map0.194
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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