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OPENSEQ.org

NUOA - NADH-quinone oxidoreductase subunit A
UniProt: P0AFC3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12082
Length: 147 (119)
Sequences: 1062
Seq/Len: 8.92

NUOA
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_E 117_L 3.517 1.00
26_L 30_M 2.436 1.00
88_W 103_A 2.185 1.00
98_V 102_E 2.066 1.00
111_L 117_L 1.975 1.00
82_A 117_L 1.887 1.00
46_K 113_G 1.806 1.00
82_A 111_L 1.761 1.00
95_S 99_G 1.715 1.00
101_V 105_I 1.67 1.00
109_V 117_L 1.647 1.00
91_S 94_E 1.615 1.00
25_G 29_L 1.605 1.00
71_V 117_L 1.581 1.00
104_A 115_V 1.543 1.00
85_L 103_A 1.502 1.00
28_C 32_V 1.493 1.00
68_F 71_V 1.485 1.00
100_F 104_A 1.483 1.00
21_I 25_G 1.439 0.99
70_L 73_M 1.384 0.99
23_A 34_G 1.372 0.99
63_R 73_M 1.346 0.99
97_W 101_V 1.327 0.99
39_G 68_F 1.318 0.99
101_V 104_A 1.299 0.99
48_V 55_D 1.298 0.99
81_E 110_L 1.27 0.98
29_L 33_G 1.236 0.98
82_A 114_L 1.214 0.98
106_F 110_L 1.205 0.97
32_V 36_F 1.182 0.97
18_I 77_I 1.175 0.97
113_G 123_L 1.164 0.97
78_F 123_L 1.14 0.96
33_G 108_F 1.136 0.96
48_V 56_S 1.12 0.96
110_L 114_L 1.12 0.96
14_W 17_A 1.107 0.95
115_V 118_V 1.096 0.95
25_G 93_R 1.087 0.95
45_S 48_V 1.076 0.94
37_L 107_I 1.075 0.94
113_G 120_I 1.071 0.94
96_G 123_L 1.068 0.94
34_G 38_G 1.066 0.94
63_R 97_W 1.061 0.94
35_W 40_R 1.051 0.93
52_S 71_V 1.041 0.93
25_G 36_F 1.025 0.92
30_M 33_G 1.02 0.92
40_R 47_N 1.017 0.92
107_I 117_L 1.01 0.91
56_S 66_A 1.005 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rkoA211000.221Contact Map0.272
4he8A20.80951000.31Contact Map0.289
3mk7C40.68716.50.954Contact Map0.277
3aqpA20.83674.80.957Contact Map0.23
2cavA10.33332.70.962Contact Map
2xq2A10.85712.60.962Contact Map0.246
4bw5A40.95922.20.964Contact Map0.291
2kv5A10.22452.20.964Contact Map0.368
4djkA20.92522.20.964Contact Map0.253
2nrgA10.40142.10.964Contact Map0.514

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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