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GLNH - Glutamine-binding periplasmic protein
UniProt: P0AEQ3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10386
Length: 248 (225)
Sequences: 10807
Seq/Len: 48.03

GLNH
Paralog alert: 0.90 [within 20: 0.42] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_A 173_A 3.823 1.00
30_A 84_V 3.473 1.00
26_K 66_E 3.377 1.00
60_E 228_T 3.106 1.00
105_D 227_K 2.615 1.00
158_F 167_E 2.483 1.00
28_V 66_E 2.403 1.00
95_D 98_K 2.396 1.00
93_I 208_G 2.39 1.00
234_T 237_E 2.363 1.00
93_I 98_K 2.267 1.00
219_R 223_N 2.23 1.00
236_N 240_K 2.224 1.00
26_K 64_D 2.215 1.00
78_A 84_V 2.17 1.00
28_V 68_K 2.146 1.00
125_S 128_D 2.086 1.00
56_A 59_K 2.083 1.00
101_I 210_A 2.075 1.00
124_K 128_D 2.066 1.00
143_V 157_Q 2.062 1.00
58_A 65_Y 2.054 1.00
160_N 163_N 2.018 1.00
227_K 231_E 2.003 1.00
133_V 156_R 1.975 1.00
211_F 219_R 1.972 1.00
143_V 147_K 1.934 1.00
211_F 222_V 1.901 1.00
80_Q 100_A 1.898 1.00
102_D 219_R 1.858 1.00
56_A 234_T 1.858 1.00
133_V 154_D 1.849 1.00
52_D 241_K 1.817 1.00
178_H 183_I 1.8 1.00
105_D 223_N 1.78 1.00
212_P 215_S 1.743 1.00
56_A 60_E 1.709 1.00
60_E 225_A 1.631 1.00
56_A 229_L 1.618 1.00
88_L 209_I 1.618 1.00
164_A 176_V 1.615 1.00
216_D 220_D 1.611 1.00
220_D 224_G 1.61 1.00
104_S 223_N 1.607 1.00
52_D 242_W 1.607 1.00
60_E 232_N 1.581 1.00
115_M 183_I 1.574 1.00
78_A 83_N 1.556 1.00
29_V 54_W 1.55 1.00
102_D 214_G 1.55 1.00
132_K 174_D 1.505 1.00
117_K 120_N 1.449 1.00
138_S 159_P 1.432 1.00
55_A 67_L 1.411 1.00
109_K 206_Q 1.391 0.99
134_V 175_A 1.386 0.99
118_A 196_K 1.372 0.99
117_K 171_N 1.364 0.99
167_E 172_R 1.344 0.99
29_V 86_L 1.336 0.99
168_L 173_A 1.32 0.99
104_S 222_V 1.314 0.99
221_K 224_G 1.314 0.99
96_E 99_K 1.313 0.99
180_T 184_L 1.3 0.99
70_M 78_A 1.297 0.99
159_P 163_N 1.295 0.99
50_D 107_Y 1.292 0.99
82_K 212_P 1.287 0.99
40_F 47_V 1.266 0.99
224_G 228_T 1.259 0.99
61_L 225_A 1.258 0.99
145_Y 149_N 1.258 0.99
76_I 101_I 1.256 0.99
114_V 175_A 1.25 0.99
102_D 216_D 1.247 0.99
75_I 87_A 1.243 0.98
130_D 152_T 1.238 0.98
234_T 238_I 1.23 0.98
119_N 196_K 1.23 0.98
57_I 225_A 1.215 0.98
221_K 225_A 1.202 0.98
225_A 228_T 1.188 0.98
135_A 158_F 1.184 0.98
133_V 174_D 1.184 0.98
167_E 173_A 1.182 0.98
86_L 211_F 1.182 0.98
168_L 176_V 1.175 0.98
86_L 222_V 1.174 0.98
41_K 69_P 1.169 0.97
127_K 130_D 1.167 0.97
49_F 239_Y 1.166 0.97
49_F 238_I 1.154 0.97
87_A 91_I 1.147 0.97
137_K 140_T 1.14 0.97
91_I 210_A 1.134 0.97
144_D 148_A 1.132 0.97
228_T 232_N 1.132 0.97
55_A 59_K 1.127 0.97
225_A 229_L 1.12 0.96
71_D 74_G 1.12 0.96
29_V 65_Y 1.115 0.96
158_F 164_A 1.109 0.96
112_L 142_S 1.098 0.96
230_R 235_Y 1.089 0.96
168_L 195_F 1.083 0.96
111_G 180_T 1.081 0.95
113_L 180_T 1.079 0.95
60_E 229_L 1.074 0.95
54_W 88_L 1.072 0.95
51_V 55_A 1.066 0.95
135_A 164_A 1.064 0.95
77_P 80_Q 1.062 0.95
94_T 97_R 1.052 0.95
118_A 194_Q 1.049 0.94
45_K 55_A 1.047 0.94
49_F 243_F 1.044 0.94
53_L 235_Y 1.042 0.94
54_W 67_L 1.04 0.94
102_D 213_K 1.036 0.94
147_K 157_Q 1.032 0.94
166_M 170_T 1.022 0.93
25_K 63_L 1.022 0.93
116_V 198_V 1.02 0.93
52_D 55_A 1.011 0.93
113_L 197_A 1.007 0.93
116_V 175_A 1.002 0.92
63_L 221_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h7mA10.93951000.225Contact Map0.791
1wdnA10.91131000.227Contact Map0.806
4f3pA20.99191000.229Contact Map0.81
2ylnA10.98391000.232Contact Map0.818
3k4uA60.91941000.238Contact Map0.834
2yjpA30.98791000.24Contact Map0.843
4kqpA10.91941000.242Contact Map0.804
3hv1A20.96771000.242Contact Map0.783
3kzgA40.90731000.243Contact Map0.892
1xt8A20.98791000.243Contact Map0.857

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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