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OPENSEQ.org
DMA - DNA adenine methylase
UniProt: P0AEE8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10204
Length: 278 (266)
Sequences: 1308
Seq/Len: 4.92
DMA
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_Y 226_S 5.494 1.00
166_A 208_H 3.985 1.00
229_D 234_R 3.485 1.00
177_V 224_L 3.278 1.00
69_R 72_E 3 1.00
70_T 148_L 2.805 1.00
36_V 39_G 2.733 1.00
164_S 208_H 2.569 1.00
214_E 240_A 2.511 1.00
21_I 265_L 2.306 1.00
213_A 225_I 2.284 1.00
224_L 265_L 2.239 1.00
20_D 23_R 2.228 1.00
202_T 205_Q 2.183 1.00
71_D 149_Y 2.171 1.00
30_C 51_I 2.104 1.00
64_N 67_K 2.095 1.00
42_F 52_L 2.088 1.00
36_V 52_L 2.041 1.00
188_S 191_A 2.037 1.00
24_H 243_H 2.03 1.00
170_A 212_I 1.925 1.00
13_G 38_A 1.917 1.00
94_F 110_L 1.896 1.00
21_I 41_V 1.88 1.00
213_A 223_V 1.873 1.00
53_A 168_S 1.87 1.00
42_F 158_A 1.838 1.00
76_A 109_V 1.789 1.00
53_A 163_E 1.779 1.00
53_A 161_Y 1.736 1.00
51_I 161_Y 1.736 1.00
185_A 232_L 1.725 1.00
58_D 107_R 1.703 1.00
205_Q 208_H 1.702 1.00
30_C 176_S 1.684 0.99
7_F 62_L 1.671 0.99
210_A 214_E 1.639 0.99
36_V 42_F 1.608 0.99
32_V 51_I 1.594 0.99
224_L 267_L 1.577 0.99
210_A 237_Y 1.559 0.99
246_K 262_D 1.539 0.99
206_Q 237_Y 1.508 0.99
32_V 176_S 1.497 0.98
11_A 251_I 1.49 0.98
62_L 66_V 1.477 0.98
58_D 110_L 1.468 0.98
178_V 216_L 1.464 0.98
185_A 203_L 1.462 0.98
163_E 167_D 1.447 0.98
167_D 170_A 1.446 0.98
169_M 216_L 1.443 0.98
52_L 160_F 1.438 0.98
204_E 207_A 1.424 0.98
70_T 152_A 1.403 0.97
208_H 212_I 1.401 0.97
22_K 44_N 1.397 0.97
243_H 267_L 1.392 0.97
203_L 232_L 1.389 0.97
248_R 260_K 1.377 0.97
244_V 262_D 1.377 0.97
214_E 239_R 1.368 0.97
78_R 145_E 1.367 0.97
98_F 110_L 1.356 0.97
234_R 244_V 1.339 0.96
30_C 49_R 1.333 0.96
231_M 235_E 1.329 0.96
169_M 180_C 1.326 0.96
64_N 68_M 1.307 0.95
65_I 108_A 1.296 0.95
173_D 176_S 1.294 0.95
185_A 230_T 1.291 0.95
88_A 92_Y 1.278 0.95
62_L 112_L 1.277 0.95
90_V 93_Q 1.271 0.95
39_G 42_F 1.263 0.94
76_A 106_R 1.241 0.94
203_L 207_A 1.235 0.93
43_L 151_F 1.226 0.93
6_A 40_S 1.226 0.93
31_L 42_F 1.213 0.93
144_P 147_E 1.21 0.92
47_F 50_Y 1.203 0.92
105_F 109_V 1.189 0.92
65_I 73_Y 1.185 0.91
165_Y 208_H 1.185 0.91
92_Y 95_R 1.184 0.91
72_E 105_F 1.161 0.90
216_L 223_V 1.16 0.90
252_S 257_T 1.145 0.89
42_F 50_Y 1.144 0.89
7_F 66_V 1.143 0.89
32_V 172_A 1.138 0.89
116_R 121_G 1.133 0.89
226_S 263_E 1.132 0.89
76_A 105_F 1.127 0.88
180_C 209_L 1.123 0.88
165_Y 209_L 1.119 0.88
74_V 149_Y 1.118 0.88
32_V 168_S 1.114 0.88
118_G 131_F 1.101 0.87
103_D 106_R 1.096 0.86
60_I 160_F 1.093 0.86
70_T 149_Y 1.078 0.85
229_D 244_V 1.076 0.85
71_D 75_Q 1.076 0.85
25_L 177_V 1.072 0.85
241_K 267_L 1.065 0.84
29_E 175_A 1.062 0.84
185_A 233_T 1.055 0.83
53_A 162_C 1.053 0.83
163_E 171_R 1.038 0.82
246_K 260_K 1.036 0.82
9_K 122_L 1.034 0.82
234_R 242_L 1.025 0.81
170_A 238_Q 1.022 0.81
138_Y 141_P 1.022 0.81
126_N 134_P 1.019 0.80
120_N 258_R 1.018 0.80
179_Y 263_E 1.014 0.80
169_M 178_V 1.011 0.80
17_L 245_V 1.008 0.79
227_N 233_T 1.008 0.79
65_I 105_F 1.004 0.79
209_L 225_I 1.001 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2g1pA211000.108Contact Map0.785
2dpmA10.9641000.159Contact Map0.796
1yf3A20.90291000.221Contact Map0.692
3tmaA10.615193.90.929Contact Map0.482
1g60A20.4388930.931Contact Map0.585
1booA10.345391.90.933Contact Map0.659
1eg2A10.356188.90.938Contact Map0.655
2r6zA20.658388.60.938Contact Map0.486
4bluA20.79587.30.939Contact Map0.271
2oo3A10.802286.10.94Contact Map0.252
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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