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OPENSEQ.org
YGGE - Uncharacterized protein YggE
UniProt: P0ADS6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11244
Length: 246 (226)
Sequences: 942
Seq/Len: 4.17
YGGE
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
85_D 120_R 3.266 1.00
55_A 61_A 3.219 1.00
53_V 65_A 3.032 1.00
36_A 157_A 2.964 1.00
57_D 60_T 2.734 1.00
34_G 164_N 2.639 1.00
166_I 170_Q 2.387 1.00
37_S 221_Q 2.369 1.00
38_V 157_A 2.154 1.00
46_T 146_G 2.138 1.00
31_V 227_D 2.054 1.00
158_R 172_L 1.984 1.00
66_D 213_E 1.953 1.00
96_D 110_R 1.931 1.00
93_T 111_A 1.926 1.00
121_Q 124_K 1.911 1.00
95_P 106_L 1.894 1.00
61_A 111_A 1.859 1.00
113_R 214_T 1.858 1.00
130_D 213_E 1.835 1.00
40_A 153_Y 1.809 1.00
162_I 175_G 1.78 1.00
62_K 66_D 1.762 0.99
30_I 232_L 1.761 0.99
64_Q 67_E 1.742 0.99
165_A 228_V 1.694 0.99
77_E 83_K 1.688 0.99
147_V 222_F 1.661 0.99
39_D 219_A 1.627 0.99
155_D 167_H 1.614 0.99
168_Q 188_Y 1.611 0.99
120_R 148_A 1.608 0.99
67_E 71_Q 1.595 0.99
95_P 108_G 1.574 0.98
54_A 96_D 1.547 0.98
162_I 228_V 1.541 0.98
62_K 91_L 1.535 0.98
182_P 231_Q 1.496 0.98
183_V 186_V 1.483 0.98
45_A 125_L 1.459 0.97
97_Y 108_G 1.455 0.97
32_T 165_A 1.44 0.97
52_N 139_E 1.43 0.97
58_A 111_A 1.423 0.97
157_A 224_D 1.419 0.97
162_I 176_F 1.411 0.96
75_F 79_N 1.41 0.96
178_R 232_L 1.41 0.96
44_I 118_T 1.393 0.96
40_A 157_A 1.385 0.96
49_I 132_A 1.375 0.96
93_T 133_L 1.358 0.95
152_A 156_K 1.351 0.95
184_Y 231_Q 1.348 0.95
69_V 113_R 1.337 0.95
160_A 163_D 1.33 0.95
39_D 221_Q 1.324 0.94
140_I 143_V 1.323 0.94
75_F 131_G 1.314 0.94
113_R 215_Y 1.312 0.94
181_G 232_L 1.308 0.94
84_K 219_A 1.29 0.93
185_S 229_V 1.284 0.93
43_D 148_A 1.283 0.93
88_S 215_Y 1.278 0.93
49_I 117_V 1.278 0.93
65_A 111_A 1.266 0.92
155_D 171_E 1.252 0.92
172_L 188_Y 1.238 0.91
88_S 113_R 1.237 0.91
91_L 111_A 1.227 0.91
54_A 110_R 1.225 0.91
70_A 74_S 1.216 0.90
75_F 128_L 1.206 0.90
170_Q 180_L 1.195 0.89
72_Y 115_V 1.181 0.89
158_R 171_E 1.18 0.88
119_L 128_L 1.172 0.88
122_L 125_L 1.16 0.87
183_V 228_V 1.156 0.87
186_V 228_V 1.152 0.87
98_D 107_K 1.145 0.86
113_R 213_E 1.144 0.86
87_S 218_A 1.133 0.86
170_Q 174_N 1.128 0.85
53_V 64_Q 1.118 0.85
159_K 163_D 1.103 0.83
176_F 186_V 1.1 0.83
154_K 168_Q 1.099 0.83
48_A 141_R 1.091 0.83
65_A 113_R 1.085 0.82
163_D 166_I 1.084 0.82
55_A 64_Q 1.08 0.82
66_D 126_N 1.077 0.81
156_K 160_A 1.073 0.81
128_L 131_G 1.066 0.81
44_I 146_G 1.064 0.80
69_V 115_V 1.057 0.80
160_A 164_N 1.057 0.80
159_K 174_N 1.054 0.79
87_S 116_E 1.054 0.79
34_G 165_A 1.045 0.79
50_E 137_L 1.042 0.78
166_I 177_H 1.041 0.78
16_G 19_A 1.039 0.78
59_A 63_K 1.037 0.78
151_D 164_N 1.031 0.77
109_Y 138_N 1.02 0.76
46_T 81_I 1.015 0.76
124_K 127_S 1.004 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hvzA40.8781000.271Contact Map0.741
2jnaA20.369938.80.944Contact Map0.33
2nocA10.345517.20.953Contact Map0.611
1y0gA40.654514.50.955Contact Map0.022
4b5cA30.41069.20.958Contact Map0.29
4jggA20.68296.20.962Contact Map0.172
3zbiC140.195160.962Contact Map
2kgwA10.40655.20.963Contact Map0.403
2zzsA320.3745.20.963Contact Map0.079
2aizP10.40244.80.964Contact Map0.169
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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