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OPENSEQ.org
DDG - Protein Ddg
UniProt: P0ACV2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12901
Length: 306 (298)
Sequences: 1929
Seq/Len: 6.47
DDG
Paralog alert: 0.59 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: DDG HTRB MSBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
270_A 274_K 3.47 1.00
71_S 74_E 3.263 1.00
81_E 285_E 3.028 1.00
111_E 251_R 3.009 1.00
60_R 79_I 2.793 1.00
109_D 251_R 2.727 1.00
63_L 75_R 2.707 1.00
70_H 74_E 2.68 1.00
46_A 84_R 2.645 1.00
212_P 270_A 2.617 1.00
69_Q 281_M 2.599 1.00
115_N 256_P 2.583 1.00
111_E 253_F 2.565 1.00
41_G 87_G 2.512 1.00
60_R 76_E 2.472 1.00
214_F 277_E 2.454 1.00
244_K 251_R 2.358 1.00
221_T 273_N 2.344 1.00
112_G 115_N 2.297 1.00
188_A 193_E 2.268 1.00
117_K 121_M 2.212 1.00
212_P 217_E 2.167 1.00
274_K 277_E 2.093 1.00
33_P 36_V 2.091 1.00
113_L 117_K 2.061 1.00
58_I 292_R 2.036 1.00
61_K 64_E 1.991 1.00
64_E 72_A 1.981 1.00
155_P 178_G 1.978 1.00
67_F 70_H 1.945 1.00
150_M 193_E 1.921 1.00
70_H 78_M 1.917 1.00
237_L 254_I 1.851 1.00
65_L 216_V 1.848 1.00
49_R 56_E 1.837 1.00
238_T 255_T 1.75 1.00
70_H 75_R 1.738 1.00
77_K 81_E 1.729 1.00
118_R 122_Q 1.689 1.00
59_A 79_I 1.673 1.00
64_E 75_R 1.655 1.00
119_A 237_L 1.652 1.00
41_G 45_G 1.628 1.00
211_A 270_A 1.613 1.00
124_R 235_A 1.611 1.00
238_T 257_E 1.555 0.99
242_V 283_A 1.55 0.99
154_R 157_N 1.545 0.99
209_S 269_A 1.538 0.99
8_S 11_F 1.537 0.99
276_I 280_I 1.497 0.99
115_N 118_R 1.489 0.99
92_E 243_R 1.473 0.99
289_W 293_R 1.455 0.99
152_T 185_I 1.451 0.99
255_T 275_I 1.429 0.99
74_E 77_K 1.42 0.99
114_D 118_R 1.418 0.99
226_Y 269_A 1.409 0.99
212_P 274_K 1.406 0.99
37_L 91_V 1.406 0.99
128_V 239_V 1.405 0.99
242_V 251_R 1.404 0.99
27_W 31_Q 1.372 0.98
59_A 82_N 1.363 0.98
242_V 253_F 1.356 0.98
153_Y 176_M 1.352 0.98
275_I 278_K 1.35 0.98
49_R 80_A 1.347 0.98
127_M 234_A 1.33 0.98
74_E 78_M 1.326 0.98
175_A 193_E 1.324 0.98
43_R 47_M 1.324 0.98
255_T 278_K 1.315 0.98
135_S 287_Y 1.305 0.97
291_H 295_K 1.293 0.97
201_Q 291_H 1.285 0.97
66_C 294_F 1.282 0.97
277_E 281_M 1.281 0.97
42_T 84_R 1.269 0.97
186_V 190_K 1.264 0.97
199_P 225_T 1.263 0.97
210_F 296_T 1.263 0.97
42_T 88_M 1.263 0.97
131_V 276_I 1.263 0.97
211_A 273_N 1.254 0.96
78_M 285_E 1.24 0.96
57_S 61_K 1.238 0.96
214_F 281_M 1.237 0.96
243_R 286_Q 1.233 0.96
115_N 237_L 1.227 0.96
55_R 291_H 1.219 0.96
201_Q 289_W 1.216 0.96
47_M 51_F 1.207 0.95
126_V 235_A 1.195 0.95
63_L 70_H 1.178 0.94
210_F 217_E 1.178 0.94
137_E 196_W 1.174 0.94
156_H 162_E 1.172 0.94
35_P 39_F 1.163 0.94
163_W 167_R 1.162 0.94
105_R 145_L 1.16 0.94
297_R 301_E 1.142 0.93
39_F 42_T 1.141 0.93
185_I 195_V 1.139 0.93
87_G 90_L 1.135 0.93
125_G 189_L 1.131 0.93
238_T 275_I 1.127 0.93
136_L 198_A 1.127 0.93
201_Q 288_L 1.117 0.92
100_P 103_R 1.114 0.92
166_T 170_M 1.114 0.92
183_R 186_V 1.11 0.92
53_K 56_E 1.108 0.92
56_E 60_R 1.108 0.92
271_Y 274_K 1.102 0.91
39_F 43_R 1.099 0.91
201_Q 293_R 1.097 0.91
46_A 80_A 1.095 0.91
202_D 296_T 1.086 0.91
85_S 88_M 1.085 0.91
299_V 302_S 1.077 0.90
275_I 279_E 1.073 0.90
210_F 220_A 1.071 0.90
35_P 38_C 1.06 0.89
216_V 297_R 1.053 0.89
38_C 88_M 1.046 0.88
150_M 177_I 1.045 0.88
61_K 216_V 1.042 0.88
129_V 199_P 1.032 0.87
31_Q 36_V 1.028 0.87
287_Y 294_F 1.026 0.87
117_K 120_Q 1.013 0.86
103_R 107_W 1.01 0.86
7_F 12_L 1.006 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iuqA10.924896.40.909Contact Map0.534
2i3sB30.10467.20.967Contact Map0.153
1p3qQ20.176550.97Contact Map0.785
4gycB10.29084.90.97Contact Map0
4gr6A20.19934.60.97Contact Map0.517
3iz6M10.31054.30.971Contact Map0.218
3ka1A20.16674.20.971Contact Map0.475
2py8A40.16673.50.972Contact Map0.367
2wwbB10.11113.20.973Contact Map0.217
2aswA20.179730.973Contact Map0.094
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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