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OPENSEQ.org

GLRX4 - Glutaredoxin-4
UniProt: P0AC69 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12181
Length: 115 (106)
Sequences: 1081
Seq/Len: 10.20

GLRX4
Paralog alert: 0.12 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
9_Q 13_A 3.48 1.00
51_D 54_Q 3.414 1.00
19_L 74_L 3.046 1.00
9_Q 65_Y 3.004 1.00
11_Q 20_Y 2.976 1.00
25_P 49_Y 2.968 1.00
16_P 77_D 2.816 1.00
62_L 71_F 2.657 1.00
35_Q 88_I 2.365 1.00
60_A 64_K 2.362 1.00
41_A 47_F 2.357 1.00
36_A 87_V 2.3 1.00
66_A 75_W 2.106 1.00
36_A 84_C 2.081 1.00
24_S 51_D 2.056 1.00
10_R 14_E 1.965 1.00
56_P 60_A 1.883 1.00
7_K 55_N 1.753 1.00
71_F 80_L 1.715 1.00
42_A 91_Y 1.625 1.00
29_S 51_D 1.556 1.00
18_L 48_A 1.504 1.00
52_I 71_F 1.493 1.00
19_L 36_A 1.46 1.00
18_L 50_V 1.45 1.00
39_A 88_I 1.439 1.00
5_I 9_Q 1.398 0.99
35_Q 84_C 1.351 0.99
6_E 10_R 1.334 0.99
76_V 99_L 1.308 0.99
7_K 11_Q 1.295 0.99
74_L 87_V 1.287 0.99
84_C 88_I 1.245 0.98
90_M 99_L 1.213 0.98
38_Q 42_A 1.196 0.98
43_C 91_Y 1.133 0.97
62_L 80_L 1.133 0.97
76_V 100_I 1.129 0.97
29_S 56_P 1.089 0.96
9_Q 12_I 1.075 0.95
11_Q 18_L 1.059 0.95
97_Q 101_K 1.04 0.94
11_Q 50_V 1.015 0.93
98_Q 102_E 1.01 0.93
45_E 100_I 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wciA2199.90.497Contact Map0.781
2jadA10.947899.90.551Contact Map0.485
3gx8A1199.80.583Contact Map0.646
2wemA40.973999.80.583Contact Map0.699
2ltkA10.947899.80.59Contact Map0.585
1wikA10.947899.80.59Contact Map0.759
3ipzA10.921799.80.591Contact Map0.677
2yanA20.895799.80.595Contact Map0.827
3zywA20.956599.80.604Contact Map0.792
1u6tA10.817499.70.637Contact Map0.515

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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