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OPENSEQ.org

ZUR - Zinc uptake regulation protein
UniProt: P0AC51 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11929
Length: 171 (143)
Sequences: 2290
Seq/Len: 16.01

ZUR
Paralog alert: 0.68 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FUR ZUR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_A 145_A 3.634 1.00
105_R 142_L 3.246 1.00
104_D 133_R 3.062 1.00
131_A 147_V 2.776 1.00
106_C 143_C 2.767 1.00
35_M 76_V 2.617 1.00
132_L 139_A 2.521 1.00
106_C 146_C 2.4 1.00
104_D 142_L 2.187 1.00
143_C 146_C 2.182 1.00
85_Y 88_C 1.937 1.00
129_G 144_A 1.911 1.00
22_V 73_Q 1.898 1.00
103_C 106_C 1.888 1.00
14_E 29_L 1.885 1.00
123_T 127_K 1.81 1.00
101_F 130_F 1.808 1.00
44_A 67_L 1.795 1.00
70_L 75_F 1.768 1.00
103_C 143_C 1.717 1.00
41_A 100_M 1.692 1.00
68_D 78_K 1.67 1.00
130_F 144_A 1.604 1.00
24_L 29_L 1.58 1.00
71_L 78_K 1.569 1.00
97_T 135_N 1.512 1.00
71_L 76_V 1.491 1.00
96_H 100_M 1.488 1.00
104_D 140_H 1.469 1.00
103_C 146_C 1.439 1.00
43_S 46_D 1.433 1.00
34_L 47_L 1.429 1.00
48_L 60_P 1.411 1.00
30_E 33_R 1.381 0.99
41_A 86_V 1.377 0.99
78_K 83_N 1.37 0.99
133_R 142_L 1.353 0.99
48_L 52_R 1.335 0.99
66_A 69_F 1.328 0.99
114_A 120_I 1.321 0.99
84_S 88_C 1.282 0.99
102_I 140_H 1.248 0.99
29_L 33_R 1.246 0.98
34_L 50_L 1.223 0.98
101_F 110_K 1.22 0.98
83_N 86_V 1.217 0.98
15_K 19_Q 1.211 0.98
97_T 121_M 1.208 0.98
44_A 60_P 1.181 0.98
41_A 59_K 1.151 0.97
110_K 128_M 1.142 0.97
83_N 88_C 1.127 0.97
31_V 66_A 1.124 0.97
82_T 86_V 1.114 0.96
38_Q 42_I 1.11 0.96
26_P 30_E 1.094 0.96
34_L 51_L 1.082 0.96
38_Q 50_L 1.081 0.95
49_D 52_R 1.075 0.95
16_I 20_R 1.067 0.95
33_R 37_L 1.062 0.95
69_F 73_Q 1.044 0.94
119_D 123_T 1.034 0.94
27_Q 62_T 1.033 0.94
41_A 96_H 1.03 0.94
81_S 84_S 1.016 0.93
51_L 58_A 1.012 0.93
94_P 135_N 1.008 0.93
35_M 42_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i7hA20.91231000.247Contact Map0.814
4etsA20.87131000.247Contact Map0.756
2xigA40.85381000.265Contact Map0.826
2fe3A20.83041000.275Contact Map0.828
3eyyA20.83041000.295Contact Map0.599
3mwmA20.79531000.3Contact Map0.637
2o03A10.76021000.311Contact Map0.5
2w57A20.83631000.315Contact Map0.864
1mzbA10.77191000.336Contact Map0.604
2fu4A20.46299.50.66Contact Map0.804

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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