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OPENSEQ.org
KDSC - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
UniProt: P0ABZ4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12804
Length: 188 (171)
Sequences: 940
Seq/Len: 5.50
KDSC
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
139_S 154_D 3.479 1.00
57_R 144_D 3.406 1.00
106_F 117_P 3.199 1.00
45_G 49_E 2.962 1.00
30_I 73_A 2.873 1.00
41_L 53_A 2.868 1.00
133_M 153_A 2.652 1.00
31_L 166_V 2.5 1.00
141_A 145_A 2.495 1.00
110_L 120_V 2.485 1.00
65_A 170_C 2.362 1.00
130_W 149_L 2.305 1.00
110_L 117_P 2.257 1.00
74_I 87_C 2.256 1.00
94_H 113_L 2.16 1.00
43_Y 53_A 2.145 1.00
133_M 139_S 2.095 1.00
140_V 169_V 2.051 1.00
101_N 104_I 2.031 1.00
30_I 106_F 2.027 1.00
108_D 112_K 1.949 1.00
27_R 119_N 1.85 1.00
160_A 163_R 1.839 1.00
65_A 70_I 1.826 1.00
158_R 168_E 1.81 1.00
107_S 135_K 1.771 1.00
78_R 89_T 1.758 1.00
123_V 169_V 1.726 1.00
22_K 154_D 1.684 1.00
171_D 180_L 1.599 0.99
140_V 157_T 1.595 0.99
106_F 110_L 1.541 0.99
84_E 88_A 1.456 0.98
31_L 123_V 1.449 0.98
71_E 93_T 1.437 0.98
42_I 56_V 1.423 0.98
115_I 120_V 1.416 0.98
96_Y 105_A 1.399 0.98
99_Q 105_A 1.392 0.98
29_L 166_V 1.377 0.98
174_L 179_K 1.329 0.97
148_L 175_L 1.315 0.97
81_K 84_E 1.314 0.96
175_L 180_L 1.299 0.96
68_S 174_L 1.297 0.96
106_F 132_V 1.287 0.96
45_G 51_L 1.287 0.96
110_L 115_I 1.286 0.96
59_G 86_R 1.282 0.96
85_D 88_A 1.26 0.95
107_S 111_E 1.252 0.95
63_R 66_L 1.248 0.95
28_L 109_L 1.246 0.95
41_L 163_R 1.234 0.95
94_H 112_K 1.194 0.93
134_E 152_R 1.189 0.93
150_I 156_V 1.178 0.93
109_L 113_L 1.17 0.92
73_A 109_L 1.161 0.92
23_A 138_L 1.156 0.92
141_A 153_A 1.151 0.91
71_E 94_H 1.148 0.91
86_R 90_L 1.138 0.91
148_L 180_L 1.137 0.91
71_E 113_L 1.135 0.91
63_R 67_T 1.124 0.90
122_Y 132_V 1.117 0.90
29_L 121_A 1.116 0.90
70_I 174_L 1.106 0.89
123_V 165_A 1.101 0.89
40_G 54_F 1.095 0.88
25_N 118_E 1.089 0.88
146_H 171_D 1.088 0.88
116_A 119_N 1.086 0.88
76_T 97_Q 1.078 0.87
103_L 135_K 1.057 0.86
87_C 95_L 1.039 0.85
33_V 37_L 1.037 0.84
25_N 119_N 1.034 0.84
87_C 97_Q 1.021 0.83
142_V 157_T 1.019 0.83
144_D 160_A 1.015 0.83
41_L 55_N 1.014 0.83
123_V 157_T 1.011 0.82
148_L 152_R 1.011 0.82
121_A 169_V 1.007 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r8eA811000.543Contact Map0.861
3n07A40.99471000.558Contact Map0.871
4navD40.94681000.566Contact Map0.811
3ij5A411000.567Contact Map0.89
3n1uA10.96281000.571Contact Map0.766
4hgnA40.93091000.582Contact Map0.9
1k1eA120.90431000.588Contact Map0.842
3ewiA20.8831000.591Contact Map0.761
3mn1A120.96281000.591Contact Map0.871
3e8mA40.87231000.597Contact Map0.825
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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