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OPENSEQ.org
PNTB - NAD(P) transhydrogenase subunit beta
UniProt: P0AB67 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10745
Length: 462 (462)
Sequences: 717
Seq/Len: 1.55
PNTB
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
310_I 379_F 3.504 1.00
385_V 417_A 3.473 1.00
312_T 414_V 3.218 1.00
379_F 412_L 3.146 1.00
85_E 147_C 3.105 1.00
399_Q 413_E 3.072 1.00
306_S 384_T 3.013 1.00
341_R 378_D 2.839 1.00
399_Q 415_W 2.808 1.00
435_Q 440_F 2.686 1.00
341_R 382_T 2.422 1.00
382_T 412_L 2.421 1.00
334_R 368_I 2.39 1.00
427_M 448_F 2.375 1.00
308_S 382_T 2.346 1.00
144_G 150_I 2.325 1.00
428_N 448_F 2.308 0.99
299_T 421_I 2.255 0.99
73_R 77_K 2.244 0.99
413_E 416_K 2.216 0.99
157_L 160_R 2.213 0.99
310_I 382_T 2.161 0.99
309_V 338_I 2.156 0.99
402_P 407_A 2.151 0.99
312_T 385_V 2.15 0.99
453_A 457_A 2.142 0.99
411_V 415_W 2.134 0.99
423_F 454_S 2.133 0.99
308_S 339_N 2.104 0.99
127_L 131_I 1.911 0.97
379_F 382_T 1.901 0.97
156_M 160_R 1.9 0.97
20_S 37_G 1.868 0.97
177_V 190_A 1.752 0.95
325_P 456_D 1.751 0.95
312_T 343_G 1.747 0.95
447_L 458_I 1.745 0.95
310_I 412_L 1.717 0.94
143_F 149_K 1.716 0.94
382_T 385_V 1.664 0.93
190_A 193_I 1.657 0.93
193_I 196_A 1.645 0.92
74_L 89_I 1.627 0.92
341_R 370_L 1.558 0.89
166_A 169_V 1.545 0.89
310_I 375_I 1.538 0.89
206_V 232_A 1.535 0.88
377_D 413_E 1.515 0.88
173_L 177_V 1.506 0.87
126_F 194_M 1.481 0.86
294_I 299_T 1.475 0.86
160_R 208_S 1.472 0.85
126_F 175_L 1.47 0.85
426_S 448_F 1.47 0.85
169_V 173_L 1.449 0.84
90_L 93_F 1.446 0.84
400_D 437_P 1.441 0.84
200_V 203_W 1.429 0.83
176_I 180_R 1.42 0.82
91_H 94_V 1.412 0.82
434_V 440_F 1.408 0.82
106_Y 178_F 1.406 0.82
225_S 260_C 1.404 0.82
135_T 225_S 1.404 0.82
141_V 203_W 1.397 0.81
302_L 419_N 1.39 0.81
225_S 258_I 1.386 0.80
447_L 454_S 1.377 0.80
304_K 336_R 1.369 0.79
454_S 457_A 1.358 0.78
422_V 444_T 1.336 0.77
308_S 341_R 1.33 0.76
27_H 30_S 1.317 0.75
453_A 456_D 1.307 0.75
342_F 364_V 1.306 0.75
400_D 441_K 1.306 0.75
157_L 163_M 1.302 0.74
92_S 256_S 1.299 0.74
223_S 260_C 1.294 0.74
331_E 335_A 1.284 0.73
284_D 403_K 1.282 0.73
308_S 378_D 1.281 0.73
10_Y 238_N 1.281 0.73
294_I 298_E 1.279 0.72
317_M 388_I 1.271 0.72
69_A 382_T 1.271 0.72
125_V 218_V 1.266 0.71
281_S 286_Q 1.264 0.71
159_N 162_K 1.263 0.71
140_V 144_G 1.259 0.71
419_N 445_H 1.258 0.71
189_L 193_I 1.257 0.70
135_T 246_A 1.248 0.70
175_L 194_M 1.245 0.69
171_S 175_L 1.242 0.69
20_S 256_S 1.239 0.69
116_I 169_V 1.229 0.68
74_L 77_K 1.227 0.68
173_L 176_I 1.225 0.68
260_C 270_V 1.225 0.68
91_H 256_S 1.219 0.67
375_I 379_F 1.218 0.67
291_H 448_F 1.214 0.67
394_V 439_F 1.213 0.67
287_E 290_E 1.208 0.66
150_I 155_L 1.189 0.64
105_S 235_M 1.186 0.64
157_L 269_S 1.176 0.63
330_T 342_F 1.172 0.63
93_F 223_S 1.169 0.62
326_V 386_L 1.165 0.62
342_F 374_E 1.157 0.61
420_V 443_N 1.155 0.61
83_M 269_S 1.153 0.61
50_F 457_A 1.15 0.60
227_W 253_A 1.15 0.60
295_T 298_E 1.148 0.60
396_P 438_L 1.145 0.60
426_S 435_Q 1.145 0.60
69_A 177_V 1.142 0.60
427_M 435_Q 1.14 0.59
291_H 428_N 1.14 0.59
341_R 375_I 1.138 0.59
144_G 149_K 1.137 0.59
137_T 199_L 1.135 0.59
91_H 98_A 1.134 0.59
294_I 421_I 1.132 0.59
98_A 253_A 1.128 0.58
102_G 129_I 1.126 0.58
205_L 224_Y 1.123 0.58
277_T 283_G 1.122 0.58
421_I 447_L 1.122 0.58
194_M 198_A 1.12 0.57
209_I 276_G 1.119 0.57
370_L 373_D 1.118 0.57
14_A 243_V 1.114 0.57
293_E 435_Q 1.113 0.57
40_G 243_V 1.112 0.57
355_M 396_P 1.111 0.56
17_F 44_A 1.11 0.56
290_E 437_P 1.109 0.56
224_Y 253_A 1.108 0.56
385_V 414_V 1.106 0.56
133_A 198_A 1.105 0.56
96_L 256_S 1.095 0.55
96_L 100_L 1.093 0.55
294_I 447_L 1.091 0.54
41_M 355_M 1.091 0.54
220_M 227_W 1.09 0.54
87_V 161_H 1.089 0.54
10_Y 48_T 1.087 0.54
378_D 412_L 1.084 0.54
397_A 451_A 1.082 0.53
196_A 200_V 1.079 0.53
171_S 198_A 1.076 0.53
82_E 85_E 1.072 0.52
374_E 378_D 1.069 0.52
160_R 269_S 1.067 0.52
171_S 197_I 1.065 0.52
300_A 461_A 1.062 0.51
166_A 170_V 1.062 0.51
89_I 140_V 1.061 0.51
173_L 196_A 1.058 0.51
449_G 454_S 1.054 0.51
96_L 136_F 1.052 0.50
60_I 105_S 1.052 0.50
292_R 373_D 1.048 0.50
39_A 173_L 1.044 0.50
143_F 147_C 1.044 0.50
330_T 407_A 1.042 0.49
223_S 253_A 1.035 0.49
294_I 445_H 1.035 0.49
401_D 404_S 1.032 0.48
332_K 335_A 1.031 0.48
291_H 427_M 1.031 0.48
201_F 205_L 1.029 0.48
342_F 368_I 1.026 0.48
296_A 300_A 1.025 0.48
83_M 267_F 1.023 0.47
170_V 173_L 1.022 0.47
24_L 325_P 1.02 0.47
365_P 368_I 1.017 0.47
327_A 342_F 1.014 0.46
246_A 297_E 1.014 0.46
155_L 207_A 1.011 0.46
220_M 267_F 1.011 0.46
17_F 41_M 1.01 0.46
343_G 375_I 1.01 0.46
128_G 256_S 1.01 0.46
298_E 301_E 1.009 0.46
23_G 124_E 1.008 0.46
35_N 53_D 1.006 0.46
96_L 140_V 1.004 0.45
59_W 144_G 1.002 0.45
312_T 393_T 1.001 0.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1djlA20.43291000.485Contact Map0.732
2fsvC10.43291000.485Contact Map0.66
1pnoA20.38741000.528Contact Map0.683
1d4oA10.38531000.529Contact Map0.714
2bruC10.40261000.533Contact Map0.564
3cf4G10.335595.10.969Contact Map0.516
1ytlA40.318293.60.971Contact Map0.406
3k35A60.365893.20.971Contact Map0.604
4i5iA20.385392.70.972Contact Map0.469
3pkiA60.357192.50.972Contact Map0.576
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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