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OPENSEQ.org
FABD - Malonyl CoA-acyl carrier protein transacylase
UniProt: P0AAI9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11317
Length: 309 (302)
Sequences: 6840
Seq/Len: 22.65
FABD
Paralog alert: 0.33 [within 20: 0.10] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_S 203_A 3.84 1.00
256_Q 259_K 3.35 1.00
133_A 180_G 3.119 1.00
37_S 43_D 2.889 1.00
106_D 109_D 2.878 1.00
177_E 193_P 2.799 1.00
8_F 74_Y 2.706 1.00
123_E 211_K 2.593 1.00
23_A 34_A 2.454 1.00
249_R 253_N 2.401 1.00
213_A 245_D 2.389 1.00
139_D 142_S 2.369 1.00
258_T 262_E 2.32 1.00
131_A 176_V 2.256 1.00
116_M 119_K 2.251 1.00
35_E 108_A 2.228 1.00
231_N 260_S 2.194 1.00
172_H 204_L 2.184 1.00
74_Y 101_C 2.181 1.00
169_I 179_A 2.149 1.00
170_A 202_C 2.088 1.00
206_K 252_Y 2.027 1.00
46_A 50_Q 1.994 1.00
146_A 186_A 1.986 1.00
5_A 269_V 1.975 1.00
33_F 68_T 1.934 1.00
33_F 48_T 1.924 1.00
36_A 107_F 1.917 1.00
30_E 34_A 1.855 1.00
140_D 144_A 1.84 1.00
67_L 110_A 1.821 1.00
113_L 216_L 1.815 1.00
7_V 285_T 1.79 1.00
180_G 193_P 1.79 1.00
14_Q 18_M 1.76 1.00
172_H 175_A 1.751 1.00
245_D 249_R 1.737 1.00
37_S 45_W 1.713 1.00
87_M 269_V 1.695 1.00
213_A 248_V 1.694 1.00
299_E 302_A 1.644 1.00
182_A 186_A 1.635 1.00
229_V 263_Y 1.625 1.00
75_R 79_Q 1.62 1.00
173_K 177_E 1.62 1.00
216_L 221_F 1.619 1.00
173_K 193_P 1.611 1.00
104_V 224_P 1.608 1.00
265_A 289_V 1.595 1.00
261_V 285_T 1.592 1.00
100_V 110_A 1.569 1.00
180_G 184_K 1.563 1.00
142_S 145_K 1.559 1.00
235_K 263_Y 1.552 1.00
89_A 260_S 1.548 1.00
71_V 100_V 1.53 1.00
70_S 97_S 1.528 1.00
180_G 191_A 1.527 1.00
140_D 256_Q 1.527 1.00
116_M 215_E 1.52 1.00
39_A 111_V 1.507 1.00
32_T 75_R 1.501 1.00
133_A 176_V 1.5 1.00
31_E 34_A 1.498 1.00
263_Y 267_Q 1.495 1.00
229_V 236_C 1.489 1.00
5_A 264_M 1.483 1.00
60_W 122_Q 1.483 1.00
131_A 173_K 1.472 1.00
79_Q 84_A 1.469 1.00
33_F 72_A 1.445 1.00
19_L 69_A 1.438 1.00
58_K 122_Q 1.424 1.00
34_A 45_W 1.421 1.00
135_I 143_I 1.411 1.00
6_F 85_P 1.4 0.99
43_D 46_A 1.383 0.99
213_A 217_A 1.372 0.99
32_T 35_E 1.364 0.99
211_K 214_V 1.363 0.99
138_L 188_A 1.362 0.99
156_V 179_A 1.36 0.99
26_Y 76_V 1.357 0.99
261_V 288_I 1.337 0.99
115_E 119_K 1.328 0.99
229_V 267_Q 1.327 0.99
4_F 271_H 1.322 0.99
140_D 161_F 1.318 0.99
71_V 97_S 1.317 0.99
31_E 35_E 1.311 0.99
20_A 24_A 1.31 0.99
87_M 264_M 1.307 0.99
183_C 188_A 1.306 0.99
35_E 75_R 1.293 0.99
159_V 170_A 1.292 0.99
4_F 86_A 1.283 0.99
181_A 185_A 1.282 0.99
88_M 226_V 1.274 0.99
60_W 118_G 1.266 0.99
181_A 184_K 1.257 0.99
146_A 183_C 1.254 0.99
120_F 208_A 1.245 0.98
161_F 259_K 1.245 0.98
55_E 58_K 1.242 0.98
209_A 252_Y 1.242 0.98
133_A 191_A 1.236 0.98
206_K 209_A 1.228 0.98
149_E 182_A 1.227 0.98
214_V 217_A 1.224 0.98
138_L 143_I 1.219 0.98
231_N 250_Q 1.208 0.98
209_A 213_A 1.208 0.98
161_F 167_V 1.202 0.98
89_A 264_M 1.197 0.98
177_E 180_G 1.193 0.98
272_L 292_L 1.184 0.98
9_P 70_S 1.17 0.97
161_F 258_T 1.167 0.97
59_T 200_S 1.164 0.97
8_F 101_C 1.153 0.97
142_S 186_A 1.144 0.97
272_L 285_T 1.143 0.97
208_A 251_L 1.142 0.97
5_A 272_L 1.139 0.97
45_W 49_Q 1.136 0.97
20_A 49_Q 1.131 0.97
53_A 57_N 1.127 0.97
93_L 114_V 1.127 0.97
32_T 72_A 1.125 0.97
229_V 260_S 1.123 0.97
223_A 240_G 1.12 0.96
177_E 181_A 1.109 0.96
28_I 32_T 1.109 0.96
23_A 49_Q 1.103 0.96
55_E 61_Q 1.101 0.96
112_R 218_K 1.097 0.96
75_R 100_V 1.093 0.96
3_Q 86_A 1.088 0.96
6_F 74_Y 1.086 0.96
135_I 183_C 1.085 0.96
104_V 221_F 1.073 0.95
262_E 266_A 1.071 0.95
239_N 242_A 1.068 0.95
144_A 148_E 1.062 0.95
163_S 284_L 1.059 0.95
178_R 182_A 1.058 0.95
7_V 89_A 1.054 0.95
161_F 254_P 1.052 0.95
131_A 193_P 1.049 0.94
36_A 111_V 1.046 0.94
215_E 218_K 1.043 0.94
119_K 123_E 1.041 0.94
6_F 275_V 1.041 0.94
96_Y 114_V 1.041 0.94
227_P 236_C 1.039 0.94
116_M 120_F 1.03 0.94
137_G 190_R 1.028 0.94
36_A 68_T 1.024 0.93
200_S 251_L 1.022 0.93
75_R 78_Q 1.021 0.93
77_W 275_V 1.016 0.93
99_L 247_L 1.01 0.93
209_A 248_V 1.008 0.93
91_H 162_N 1.006 0.93
133_A 169_I 1.004 0.93
120_F 215_E 1.002 0.92
143_I 167_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k89A11100-0.011Contact Map0.752
3ezoA10.9935100-0.01Contact Map0.773
1mlaA11100-0.007Contact Map0.683
3ptwA10.9935100-0.006Contact Map0.808
3tqeA111000.001Contact Map0.806
3qatA20.99351000.003Contact Map0.789
3im8A10.99031000.006Contact Map0.8
2h1yA20.97731000.016Contact Map0.822
2cuyA20.97411000.018Contact Map0.855
3im9A10.99031000.024Contact Map0.805
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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