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OPENSEQ.org

NIRD - Nitrite reductase [NAD(P)H] small subunit
UniProt: P0A9I8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10655
Length: 108 (103)
Sequences: 3494
Seq/Len: 33.92

NIRD
Paralog alert: 0.52 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: HCAC NIRD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
6_D 103_V 3.518 1.00
78_R 81_D 3.51 1.00
44_N 55_S 2.43 1.00
10_I 99_V 2.288 1.00
43_S 93_K 2.185 1.00
42_I 92_V 2.145 1.00
98_R 105_Q 2.039 1.00
63_Q 76_R 2.037 1.00
10_I 39_V 1.978 1.00
30_I 41_A 1.942 1.00
47_P 77_F 1.934 1.00
22_L 27_Q 1.827 1.00
41_A 106_L 1.8 1.00
26_E 43_S 1.777 1.00
6_D 105_Q 1.624 1.00
96_E 107_R 1.618 1.00
8_C 13_I 1.56 1.00
52_S 71_P 1.554 1.00
43_S 95_Y 1.531 1.00
4_W 98_R 1.529 1.00
18_G 29_A 1.527 1.00
44_N 53_V 1.49 1.00
33_P 36_S 1.482 1.00
39_V 97_A 1.468 1.00
9_K 12_D 1.449 1.00
28_V 41_A 1.418 1.00
100_K 105_Q 1.405 0.99
76_R 86_E 1.39 0.99
69_A 76_R 1.387 0.99
38_Q 80_S 1.366 0.99
60_A 69_A 1.357 0.99
9_K 103_V 1.329 0.99
27_Q 44_N 1.295 0.99
14_L 17_T 1.239 0.98
31_F 42_I 1.234 0.98
18_G 68_V 1.23 0.98
78_R 85_M 1.227 0.98
15_P 32_R 1.214 0.98
39_V 104_V 1.21 0.98
41_A 97_A 1.2 0.98
54_L 92_V 1.195 0.98
8_C 12_D 1.175 0.98
63_Q 85_M 1.154 0.97
99_V 104_V 1.134 0.97
46_D 73_K 1.092 0.96
52_S 72_L 1.07 0.95
40_F 80_S 1.068 0.95
42_I 94_H 1.067 0.95
60_A 76_R 1.063 0.95
46_D 70_S 1.058 0.95
39_V 99_V 1.057 0.95
33_P 40_F 1.055 0.95
18_G 59_I 1.055 0.95
18_G 31_F 1.034 0.94
32_R 39_V 1.022 0.93
10_I 102_G 1.004 0.93
8_C 104_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jzaA10.981599.90.118Contact Map0.634
2jo6A10.981599.90.12Contact Map0.709
2i7fA20.935299.90.13Contact Map0.927
3gceA10.935299.90.13Contact Map0.856
3c0dA80.981599.90.137Contact Map0.833
2de6D30.935299.90.139Contact Map0.886
4aivA10.981599.90.146Contact Map0.809
1vm9A10.925999.90.157Contact Map0.888
1fqtA20.925999.90.159Contact Map0.885
3dqyA10.916799.90.162Contact Map0.946

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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