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FNR - Fumarate and nitrate reduction regulatory protein
UniProt: P0A9E5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10325
Length: 250 (223)
Sequences: 4628
Seq/Len: 20.75

FNR
Paralog alert: 0.76 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: CRP FNR YEIL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_S 123_E 2.978 1.00
223_M 238_A 2.971 1.00
53_Q 56_Q 2.948 1.00
51_P 120_M 2.795 1.00
73_S 120_M 2.761 1.00
79_Y 114_Q 2.747 1.00
78_S 113_A 2.698 1.00
197_R 212_S 2.646 1.00
171_A 218_F 2.631 1.00
225_A 232_T 2.574 1.00
166_A 206_L 2.425 1.00
61_A 112_F 2.416 1.00
225_A 234_E 2.389 1.00
76_I 113_A 2.317 1.00
170_L 214_L 2.294 1.00
131_D 135_K 2.279 1.00
59_F 113_A 2.274 1.00
61_A 80_T 2.227 1.00
35_N 38_E 2.221 1.00
235_N 238_A 2.147 1.00
151_I 154_D 2.084 1.00
72_R 122_C 2.041 1.00
167_E 217_R 1.951 1.00
166_A 210_T 1.944 1.00
53_Q 118_T 1.944 1.00
79_Y 112_F 1.924 1.00
87_E 202_N 1.863 1.00
125_P 128_T 1.826 1.00
75_T 117_E 1.819 1.00
236_N 240_A 1.817 1.00
165_N 168_E 1.801 1.00
216_G 220_K 1.775 1.00
178_S 233_I 1.754 1.00
192_R 230_Y 1.751 1.00
218_F 223_M 1.744 1.00
52_I 58_L 1.734 1.00
115_A 119_S 1.712 1.00
60_K 63_D 1.695 1.00
54_K 117_E 1.675 1.00
54_K 118_T 1.675 1.00
51_P 118_T 1.665 1.00
93_H 97_D 1.662 1.00
198_G 202_N 1.644 1.00
38_E 136_M 1.641 1.00
56_Q 115_A 1.623 1.00
167_E 221_S 1.595 1.00
217_R 221_S 1.591 1.00
71_I 93_H 1.586 1.00
57_T 60_K 1.576 1.00
26_S 36_E 1.553 1.00
206_L 211_I 1.55 1.00
173_F 204_L 1.511 1.00
144_M 147_M 1.503 1.00
76_I 119_S 1.497 1.00
65_L 109_H 1.492 1.00
52_I 121_V 1.474 1.00
219_Q 225_A 1.468 1.00
219_Q 226_V 1.461 1.00
77_K 89_I 1.452 1.00
41_Q 135_K 1.433 1.00
50_K 123_E 1.403 0.99
197_R 208_V 1.399 0.99
171_A 239_L 1.386 0.99
77_K 87_E 1.381 0.99
173_F 200_I 1.373 0.99
33_T 142_Q 1.356 0.99
71_I 76_I 1.348 0.99
36_E 40_D 1.346 0.99
77_K 114_Q 1.34 0.99
126_F 130_D 1.339 0.99
209_E 213_R 1.338 0.99
190_E 230_Y 1.335 0.99
134_G 141_Q 1.327 0.99
128_T 131_D 1.311 0.99
34_L 38_E 1.309 0.99
198_G 208_V 1.301 0.99
57_T 112_F 1.296 0.99
238_A 241_Q 1.26 0.99
71_I 119_S 1.259 0.99
134_G 138_N 1.256 0.99
57_T 114_Q 1.255 0.99
216_G 219_Q 1.253 0.99
68_L 129_L 1.252 0.99
45_I 128_T 1.25 0.99
101_F 150_E 1.25 0.99
77_K 116_L 1.247 0.99
190_E 232_T 1.207 0.98
237_D 240_A 1.203 0.98
46_I 124_I 1.185 0.98
212_S 216_G 1.182 0.98
131_D 134_G 1.168 0.97
170_L 204_L 1.154 0.97
154_D 158_I 1.139 0.97
160_L 172_A 1.137 0.97
41_Q 44_N 1.135 0.97
38_E 138_N 1.133 0.97
58_L 76_I 1.125 0.97
48_R 120_M 1.115 0.96
82_T 86_D 1.097 0.96
167_E 214_L 1.089 0.96
178_S 236_N 1.083 0.96
52_I 56_Q 1.076 0.95
93_H 99_V 1.076 0.95
130_D 134_G 1.062 0.95
173_F 203_Y 1.06 0.95
100_G 109_H 1.057 0.95
78_S 111_S 1.05 0.94
214_L 218_F 1.04 0.94
88_Q 157_M 1.036 0.94
204_L 211_I 1.036 0.94
164_K 172_A 1.036 0.94
215_L 226_V 1.026 0.94
53_Q 115_A 1.022 0.93
52_I 76_I 1.014 0.93
88_Q 162_S 1.003 0.93
41_Q 136_M 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gauA10.9241000.311Contact Map0.814
3d0sA20.9041000.323Contact Map0.767
3dv8A10.8681000.338Contact Map0.76
3e97A10.9161000.34Contact Map0.676
4ev0A20.861000.342Contact Map0.835
3fx3A20.921000.346Contact Map0.755
3dkwA100.91000.347Contact Map0.837
2fmyA40.8761000.351Contact Map0.808
3iwzA40.8921000.355Contact Map0.846
3e6cC10.9321000.355Contact Map0.699

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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