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FUR - Ferric uptake regulation protein
UniProt: P0A9A9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10359
Length: 148 (138)
Sequences: 3707
Seq/Len: 26.86

FUR
Paralog alert: 0.79 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: FUR ZUR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_K 137_D 3.562 1.00
94_L 123_T 3.494 1.00
95_D 132_H 3.459 1.00
26_L 68_V 2.848 1.00
96_C 133_C 2.837 1.00
121_R 139_R 2.567 1.00
122_L 129_L 2.556 1.00
96_C 138_C 2.234 1.00
93_C 96_C 2.059 1.00
133_C 138_C 2.057 1.00
119_G 134_A 1.94 1.00
94_L 132_H 1.877 1.00
93_C 133_C 1.836 1.00
15_V 20_L 1.829 1.00
25_V 42_R 1.776 1.00
94_L 130_Y 1.773 1.00
40_Y 52_L 1.743 1.00
63_D 70_R 1.731 1.00
33_H 81_E 1.725 1.00
36_A 59_L 1.717 1.00
60_N 70_R 1.711 1.00
63_D 68_V 1.708 1.00
70_R 78_S 1.707 1.00
113_E 117_K 1.7 1.00
91_L 100_I 1.602 1.00
5_N 20_L 1.548 1.00
13_L 65_A 1.542 1.00
22_I 58_V 1.533 1.00
123_T 132_H 1.51 1.00
89_D 125_H 1.432 1.00
21_K 24_E 1.417 1.00
100_I 120_I 1.416 1.00
42_R 45_D 1.414 1.00
91_L 120_I 1.388 0.99
6_T 10_K 1.345 0.99
40_Y 44_I 1.34 0.99
93_C 138_C 1.328 0.99
20_L 24_E 1.328 0.99
33_H 90_H 1.326 0.99
35_S 38_D 1.303 0.99
112_R 116_A 1.293 0.99
104_D 110_R 1.29 0.99
87_H 125_H 1.281 0.99
41_K 44_I 1.28 0.99
62_F 67_I 1.25 0.99
25_V 39_L 1.237 0.98
34_V 39_L 1.226 0.98
18_P 54_T 1.197 0.98
34_V 42_R 1.181 0.98
7_A 11_A 1.162 0.97
7_A 10_K 1.161 0.97
92_I 130_Y 1.135 0.97
120_I 134_A 1.126 0.97
134_A 137_D 1.124 0.97
23_L 62_F 1.111 0.96
30_D 42_R 1.098 0.96
30_D 34_V 1.082 0.96
100_I 118_H 1.076 0.95
75_G 79_V 1.07 0.95
25_V 43_L 1.049 0.94
21_K 46_M 1.045 0.94
58_V 61_Q 1.039 0.94
61_Q 65_A 1.027 0.94
92_I 97_G 1.026 0.94
104_D 107_I 1.02 0.93
92_I 99_V 1.012 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4etsA20.96621000.08Contact Map0.825
4i7hA20.9731000.096Contact Map0.863
2fe3A20.94591000.113Contact Map0.864
2xigA40.94591000.118Contact Map0.854
2w57A20.97971000.136Contact Map0.886
3eyyA20.96621000.137Contact Map0.618
3mwmA20.93241000.147Contact Map0.706
2o03A10.88511000.177Contact Map0.58
1mzbA10.89861000.179Contact Map0.677
2fu4A20.554199.60.568Contact Map0.862

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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