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OPENSEQ.org
SUCC - Succinyl-CoA ligase [ADP-forming] subunit beta
UniProt: P0A836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10981
Length: 388 (386)
Sequences: 1421
Seq/Len: 3.68
SUCC
Paralog alert: 0.12 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
359_K 363_D 5.687 1.00
333_I 360_K 4.894 1.00
135_K 139_E 4.299 1.00
313_A 381_V 3.78 1.00
21_V 100_A 3.568 1.00
277_K 282_E 3.169 1.00
23_Y 37_K 2.977 1.00
157_P 182_M 2.903 1.00
186_T 190_E 2.891 1.00
356_L 359_K 2.89 1.00
23_Y 34_A 2.86 1.00
241_R 254_A 2.689 1.00
179_K 183_G 2.608 1.00
32_E 70_R 2.606 1.00
15_Y 190_E 2.467 1.00
105_A 205_K 2.467 1.00
315_L 377_A 2.46 1.00
233_R 238_E 2.372 1.00
103_D 205_K 2.302 1.00
140_T 143_L 2.285 1.00
132_E 135_K 2.268 1.00
125_A 163_L 2.213 1.00
76_W 79_K 2.212 1.00
176_Q 208_D 2.184 1.00
300_E 303_K 2.166 1.00
108_L 203_I 2.154 1.00
316_V 332_I 2.064 1.00
71_A 75_N 2.04 1.00
29_R 70_R 2.012 1.00
26_T 30_E 2.001 1.00
147_V 162_E 1.986 1.00
147_V 159_Q 1.951 1.00
3_L 218_A 1.934 1.00
33_E 36_S 1.919 1.00
123_F 181_F 1.869 1.00
9_K 99_E 1.857 1.00
42_P 101_A 1.856 1.00
63_V 72_F 1.85 1.00
66_K 69_I 1.838 0.99
145_H 166_K 1.833 0.99
295_K 334_G 1.82 0.99
33_E 37_K 1.799 0.99
18_P 180_I 1.79 0.99
14_R 191_R 1.779 0.99
31_A 35_A 1.767 0.99
369_I 384_A 1.76 0.99
26_T 95_Q 1.76 0.99
64_N 68_D 1.748 0.99
12_F 187_I 1.731 0.99
94_N 236_S 1.729 0.99
68_D 71_A 1.709 0.99
299_T 338_E 1.694 0.99
25_C 30_E 1.69 0.99
32_E 36_S 1.68 0.99
380_Q 383_A 1.68 0.99
72_F 75_N 1.662 0.99
42_P 64_N 1.652 0.99
244_Q 247_Q 1.645 0.99
65_S 68_D 1.642 0.99
295_K 330_D 1.622 0.98
128_E 143_L 1.62 0.98
330_D 360_K 1.603 0.98
13_A 21_V 1.595 0.98
10_Q 14_R 1.59 0.98
112_A 121_V 1.584 0.98
13_A 19_A 1.579 0.98
161_R 165_F 1.577 0.98
172_K 175_Q 1.573 0.98
25_C 31_A 1.573 0.98
103_D 206_Q 1.539 0.98
70_R 74_E 1.522 0.97
158_Y 161_R 1.52 0.97
110_L 181_F 1.517 0.97
379_Q 383_A 1.498 0.97
123_F 163_L 1.494 0.97
323_V 327_L 1.492 0.97
42_P 62_V 1.492 0.97
218_A 229_L 1.489 0.97
191_R 228_D 1.473 0.97
14_R 228_D 1.467 0.97
155_P 160_G 1.457 0.96
32_E 69_I 1.45 0.96
248_W 300_E 1.431 0.96
25_C 35_A 1.423 0.96
381_V 385_V 1.42 0.96
17_L 211_C 1.418 0.96
12_F 214_G 1.412 0.95
31_A 69_I 1.399 0.95
353_N 356_L 1.398 0.95
40_A 43_W 1.394 0.95
114_V 188_F 1.383 0.95
8_A 214_G 1.379 0.95
346_V 381_V 1.375 0.95
187_I 191_R 1.372 0.94
193_L 196_I 1.36 0.94
71_A 74_E 1.357 0.94
106_K 203_I 1.353 0.94
28_P 32_E 1.347 0.94
150_D 154_G 1.342 0.94
45_V 96_I 1.339 0.93
36_S 66_K 1.332 0.93
57_A 76_W 1.327 0.93
27_T 30_E 1.326 0.93
30_E 33_E 1.325 0.93
259_I 382_V 1.297 0.92
122_V 146_K 1.288 0.92
361_L 368_I 1.278 0.91
204_T 210_I 1.268 0.91
263_V 269_A 1.264 0.91
195_L 217_G 1.253 0.90
165_F 174_V 1.251 0.90
279_H 375_T 1.249 0.90
244_Q 300_E 1.247 0.90
22_G 97_L 1.244 0.90
350_E 354_A 1.24 0.90
313_A 385_V 1.239 0.89
369_I 380_Q 1.238 0.89
323_V 354_A 1.235 0.89
373_G 376_D 1.226 0.89
104_I 202_V 1.223 0.89
123_F 149_L 1.218 0.88
43_W 69_I 1.214 0.88
196_I 216_L 1.212 0.88
11_L 187_I 1.202 0.87
358_A 372_K 1.197 0.87
330_D 334_G 1.192 0.87
324_R 352_N 1.189 0.87
49_V 88_A 1.186 0.87
296_E 300_E 1.176 0.86
28_P 31_A 1.17 0.86
164_A 174_V 1.168 0.85
281_G 382_V 1.166 0.85
75_N 79_K 1.166 0.85
25_C 98_V 1.161 0.85
73_A 96_I 1.149 0.84
295_K 338_E 1.141 0.84
279_H 379_Q 1.139 0.83
334_G 338_E 1.137 0.83
158_Y 165_F 1.137 0.83
330_D 356_L 1.127 0.82
21_V 37_K 1.126 0.82
80_R 92_P 1.124 0.82
28_P 66_K 1.122 0.82
262_M 305_I 1.117 0.82
299_T 303_K 1.114 0.81
44_V 62_V 1.105 0.81
10_Q 232_M 1.105 0.81
67_E 71_A 1.105 0.81
156_M 159_Q 1.103 0.81
332_I 347_V 1.102 0.81
147_V 166_K 1.098 0.80
157_P 161_R 1.098 0.80
327_L 330_D 1.098 0.80
62_V 68_D 1.098 0.80
162_E 166_K 1.095 0.80
192_D 225_R 1.095 0.80
56_K 132_E 1.091 0.80
4_H 50_H 1.09 0.80
275_I 279_H 1.087 0.79
102_T 202_V 1.084 0.79
80_R 87_D 1.084 0.79
303_K 338_E 1.084 0.79
120_R 151_P 1.083 0.79
177_F 181_F 1.082 0.79
24_A 96_I 1.079 0.79
376_D 380_Q 1.076 0.78
160_G 164_A 1.075 0.78
136_V 140_T 1.075 0.78
32_E 67_E 1.06 0.77
92_P 237_Q 1.057 0.77
175_Q 178_T 1.052 0.76
3_L 87_D 1.048 0.76
35_A 66_K 1.045 0.75
173_L 207_G 1.045 0.75
160_G 178_T 1.042 0.75
244_Q 307_S 1.026 0.73
354_A 358_A 1.025 0.73
159_Q 162_E 1.022 0.73
118_S 148_A 1.016 0.72
313_A 346_V 1.016 0.72
29_R 33_E 1.014 0.72
356_L 360_K 1.013 0.72
187_I 196_I 1.008 0.72
45_V 98_V 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pffA10.96911000.247Contact Map0.535
3mwdA10.96651000.311Contact Map0.504
2nu8B211000.34Contact Map0.765
2fp4B111000.354Contact Map0.718
3ufxB40.97161000.416Contact Map0.723
1wr2A10.53091000.773Contact Map0.68
2csuA20.90461000.796Contact Map0.53
3e5nA10.556799.10.911Contact Map0.481
3va7A10.8995990.913Contact Map0.153
2cqyA10.262998.90.918Contact Map0.522
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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