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RUVB - Holliday junction ATP-dependent DNA helicase RuvB
UniProt: P0A812 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10924
Length: 336 (329)
Sequences: 1701
Seq/Len: 5.17
RUVB
Paralog alert: 0.13 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
194_S 206_D 3.622 1.00
270_L 274_D 3.527 1.00
322_T 326_N 3.351 1.00
35_P 188_D 3.33 1.00
259_E 310_F 2.902 1.00
42_E 46_K 2.746 1.00
238_H 246_I 2.687 1.00
244_A 248_A 2.638 1.00
185_Q 188_D 2.576 1.00
205_S 243_S 2.512 1.00
272_V 320_A 2.507 1.00
274_D 330_I 2.461 1.00
50_L 235_E 2.46 1.00
196_S 224_N 2.368 1.00
134_Q 149_K 2.319 1.00
207_D 244_A 2.318 1.00
283_L 294_R 2.126 1.00
268_L 301_L 2.076 1.00
239_D 243_S 2.068 1.00
205_S 241_T 2.057 1.00
273_I 320_A 2.022 1.00
190_Q 210_L 1.98 1.00
29_E 42_E 1.943 1.00
320_A 324_A 1.939 1.00
230_V 250_A 1.91 1.00
193_V 212_V 1.876 1.00
106_P 154_P 1.871 1.00
40_Q 253_M 1.849 1.00
312_Q 319_M 1.823 1.00
273_I 325_W 1.805 1.00
195_R 199_F 1.772 1.00
277_F 322_T 1.754 1.00
320_A 325_W 1.754 1.00
237_K 240_G 1.748 1.00
269_L 328_F 1.737 1.00
270_L 328_F 1.723 1.00
190_Q 206_D 1.712 1.00
46_K 50_L 1.708 1.00
187_P 210_L 1.692 1.00
243_S 246_I 1.661 0.99
212_V 247_A 1.616 0.99
82_N 108_D 1.578 0.99
193_V 209_A 1.571 0.99
106_P 153_P 1.57 0.99
273_I 328_F 1.569 0.99
248_A 252_D 1.559 0.99
208_G 244_A 1.54 0.99
188_D 191_Y 1.531 0.99
288_A 306_I 1.527 0.99
35_P 185_Q 1.519 0.99
36_Q 255_N 1.516 0.99
6_R 9_S 1.477 0.98
186_V 210_L 1.476 0.98
46_K 49_K 1.47 0.98
73_N 83_L 1.449 0.98
325_W 332_P 1.447 0.98
268_L 290_I 1.435 0.98
190_Q 194_S 1.43 0.98
208_G 248_A 1.405 0.98
166_S 295_E 1.396 0.97
26_K 77_N 1.393 0.97
297_I 301_L 1.381 0.97
275_K 323_R 1.378 0.97
284_D 294_R 1.375 0.97
44_F 177_I 1.375 0.97
43_I 233_F 1.374 0.97
264_M 290_I 1.37 0.97
28_L 45_I 1.368 0.97
43_I 253_M 1.365 0.97
141_E 147_S 1.36 0.97
58_L 75_V 1.357 0.97
204_M 209_A 1.357 0.97
7_L 13_T 1.356 0.97
37_V 179_Q 1.351 0.97
326_N 332_P 1.348 0.97
324_A 327_H 1.333 0.96
99_A 140_G 1.326 0.96
54_A 107_H 1.323 0.96
73_N 85_T 1.318 0.96
323_R 326_N 1.293 0.96
98_A 135_L 1.293 0.96
85_T 149_K 1.289 0.95
35_P 39_S 1.273 0.95
326_N 331_T 1.273 0.95
237_K 253_M 1.269 0.95
27_L 30_E 1.268 0.95
166_S 290_I 1.268 0.95
138_M 147_S 1.248 0.94
203_E 241_T 1.227 0.94
85_T 141_E 1.226 0.94
44_F 254_L 1.215 0.93
32_V 191_Y 1.211 0.93
211_E 214_R 1.204 0.93
79_M 109_V 1.203 0.93
36_Q 182_E 1.202 0.93
211_E 215_R 1.19 0.92
272_V 311_L 1.187 0.92
40_Q 44_F 1.184 0.92
271_A 275_K 1.177 0.92
94_A 121_V 1.175 0.92
208_G 247_A 1.174 0.92
194_S 209_A 1.173 0.92
310_F 327_H 1.17 0.91
125_V 140_G 1.169 0.91
237_K 249_Q 1.163 0.91
9_S 13_T 1.159 0.91
56_D 229_R 1.15 0.90
27_L 77_N 1.147 0.90
248_A 258_A 1.138 0.90
122_V 135_L 1.135 0.90
26_K 30_E 1.131 0.89
210_L 214_R 1.13 0.89
88_G 122_V 1.127 0.89
40_Q 179_Q 1.126 0.89
245_D 249_Q 1.12 0.89
41_M 179_Q 1.118 0.89
193_V 223_A 1.099 0.88
259_E 308_Q 1.096 0.87
73_N 148_I 1.092 0.87
141_E 149_K 1.09 0.87
330_I 333_P 1.069 0.86
12_T 18_V 1.068 0.85
322_T 332_P 1.068 0.85
103_N 146_R 1.068 0.85
23_I 60_I 1.063 0.85
39_S 237_K 1.063 0.85
14_L 17_D 1.059 0.85
85_T 134_Q 1.058 0.85
324_A 328_F 1.055 0.85
272_V 281_V 1.055 0.85
40_Q 233_F 1.048 0.84
163_R 166_S 1.047 0.84
202_L 242_I 1.042 0.84
14_L 331_T 1.038 0.83
264_M 301_L 1.037 0.83
100_M 138_M 1.034 0.83
40_Q 43_I 1.032 0.83
90_V 120_P 1.031 0.83
11_G 330_I 1.029 0.82
22_A 199_F 1.022 0.82
193_V 204_M 1.016 0.81
271_A 290_I 1.013 0.81
139_I 144_A 1.011 0.81
6_R 10_A 1.01 0.81
19_A 36_Q 1.009 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1in4A10.98811000.506Contact Map0.697
3pvsA40.84821000.519Contact Map0.445
3pfiA20.98511000.541Contact Map0.669
1hqcA20.94941000.55Contact Map0.694
1sxjC10.88691000.598Contact Map0.45
1sxjD10.89881000.599Contact Map0.459
1sxjA10.90771000.615Contact Map0.271
2chqA30.84521000.622Contact Map0.575
1iqpA60.8691000.623Contact Map0.714
1sxjE10.78871000.643Contact Map0.47
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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