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OPENSEQ.org

RL1 - 50S ribosomal protein L1
UniProt: P0A7L0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10864
Length: 234 (230)
Sequences: 1708
Seq/Len: 7.43

RL1
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
181_D 184_K 4.525 1.00
175_I 189_L 3.915 1.00
83_N 86_A 3.909 1.00
14_K 32_E 3.852 1.00
85_E 89_A 3.364 1.00
10_V 13_E 3.316 1.00
50_I 165_N 3.185 1.00
67_H 187_E 3.104 1.00
39_V 179_D 2.992 1.00
148_N 151_E 2.959 1.00
85_E 88_K 2.948 1.00
67_H 184_K 2.902 1.00
115_I 156_A 2.746 1.00
28_A 182_A 2.72 1.00
30_L 216_T 2.673 1.00
28_A 32_E 2.444 1.00
46_V 196_L 2.413 1.00
103_Q 108_E 2.408 1.00
102_D 106_K 2.367 1.00
9_R 13_E 2.314 1.00
195_A 199_A 2.314 1.00
76_A 94_L 2.119 1.00
5_T 8_M 2.088 1.00
36_A 40_E 2.083 1.00
34_A 40_E 2.079 1.00
94_L 108_E 2.068 1.00
24_N 186_K 2.061 1.00
78_F 114_V 2.047 1.00
41_S 174_T 1.979 1.00
105_K 126_Q 1.969 1.00
52_A 165_N 1.912 1.00
150_A 154_K 1.853 1.00
173_T 192_L 1.812 1.00
8_M 12_R 1.79 1.00
101_A 123_V 1.779 1.00
79_T 84_A 1.752 1.00
42_V 178_V 1.733 1.00
44_V 189_L 1.717 1.00
155_N 160_Q 1.699 1.00
31_K 181_D 1.662 1.00
98_E 123_V 1.654 1.00
4_L 8_M 1.639 1.00
16_D 19_K 1.623 1.00
38_F 218_M 1.62 1.00
82_A 85_E 1.609 1.00
46_V 212_V 1.594 1.00
23_I 189_L 1.59 1.00
42_V 216_T 1.587 1.00
213_S 221_G 1.579 1.00
27_I 214_I 1.53 1.00
76_A 114_V 1.512 0.99
183_D 187_E 1.509 0.99
7_R 35_T 1.496 0.99
45_A 215_S 1.493 0.99
27_I 182_A 1.46 0.99
49_G 204_A 1.436 0.99
15_V 29_L 1.416 0.99
97_M 120_A 1.415 0.99
30_L 222_V 1.4 0.99
19_K 25_E 1.393 0.99
74_R 110_N 1.379 0.99
76_A 108_E 1.375 0.99
200_K 204_A 1.375 0.99
30_L 178_V 1.374 0.99
7_R 10_V 1.372 0.99
14_K 33_L 1.366 0.99
98_E 102_D 1.346 0.98
27_I 186_K 1.339 0.98
72_S 93_E 1.329 0.98
186_K 190_E 1.327 0.98
46_V 193_L 1.316 0.98
197_K 209_I 1.315 0.98
176_G 185_L 1.305 0.98
151_E 155_N 1.301 0.98
88_K 95_V 1.267 0.97
24_N 28_A 1.252 0.97
103_Q 106_K 1.244 0.97
94_L 103_Q 1.236 0.97
163_Y 199_A 1.223 0.97
27_I 185_L 1.223 0.97
31_K 182_A 1.211 0.96
26_A 224_V 1.209 0.96
76_A 100_L 1.204 0.96
80_Q 97_M 1.203 0.96
102_D 105_K 1.181 0.96
33_L 219_G 1.172 0.96
30_L 34_A 1.171 0.95
4_L 9_R 1.169 0.95
96_G 99_D 1.161 0.95
84_A 95_V 1.152 0.95
10_V 14_K 1.149 0.95
80_Q 123_V 1.142 0.95
45_A 172_H 1.138 0.94
216_T 219_G 1.118 0.94
44_V 192_L 1.105 0.93
104_I 111_F 1.1 0.93
170_I 211_K 1.1 0.93
30_L 33_L 1.094 0.93
86_A 150_A 1.079 0.92
22_D 25_E 1.055 0.91
117_S 147_P 1.053 0.91
182_A 186_K 1.039 0.90
7_R 11_I 1.008 0.88
212_V 224_V 1.007 0.88
82_A 147_P 1.005 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wwq5111000.123Contact Map0.59
3j3w510.99151000.138Contact Map0.415
3bboD111000.139Contact Map0.617
3qoyA111000.147Contact Map0.795
3u42A10.97441000.151Contact Map0.738
1i2aA10.89741000.281Contact Map0.673
3j21A10.88461000.283Contact Map0.402
3j3bz10.88031000.293Contact Map0.487
2zkr510.86321000.296Contact Map0.542
3zf7J10.87611000.3Contact Map0.452

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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