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OPENSEQ.org
QUEA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase
UniProt: P0A7F9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10812
Length: 356 (346)
Sequences: 1516
Seq/Len: 4.38
QUEA
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_H 326_A 5.125 1.00
234_Q 238_D 4.531 1.00
317_Y 321_M 3.504 1.00
7_S 304_E 3.492 1.00
55_L 243_A 3.188 1.00
325_K 329_E 2.886 1.00
14_L 331_K 2.832 1.00
219_T 222_D 2.769 1.00
58_F 202_F 2.72 1.00
60_N 202_F 2.617 1.00
194_R 200_M 2.592 1.00
243_A 248_N 2.495 1.00
199_E 239_A 2.457 1.00
41_G 45_D 2.422 1.00
13_S 331_K 2.406 1.00
242_A 246_R 2.25 1.00
40_H 332_Y 2.241 1.00
18_Y 158_E 2.172 1.00
191_E 195_A 2.149 1.00
31_L 319_H 2.093 1.00
118_T 130_E 2.072 1.00
191_E 194_R 2.02 1.00
230_A 276_F 2.02 1.00
26_C 164_L 1.993 1.00
106_E 118_T 1.972 1.00
251_I 295_A 1.962 1.00
36_G 319_H 1.945 1.00
22_E 25_S 1.939 1.00
284_I 288_F 1.936 1.00
172_K 231_E 1.903 1.00
233_P 236_V 1.891 1.00
146_H 157_D 1.882 1.00
60_N 171_E 1.872 1.00
60_N 204_T 1.871 1.00
41_G 49_K 1.855 1.00
169_Y 182_G 1.847 1.00
30_S 49_K 1.842 1.00
51_N 248_N 1.839 1.00
80_V 95_I 1.835 1.00
238_D 242_A 1.815 1.00
25_S 44_T 1.814 1.00
201_A 239_A 1.812 1.00
62_R 163_E 1.81 1.00
252_A 261_L 1.81 1.00
48_D 196_K 1.796 1.00
149_L 153_I 1.775 1.00
225_M 306_T 1.757 1.00
106_E 116_N 1.744 0.99
47_L 196_K 1.717 0.99
65_P 162_R 1.716 0.99
249_R 295_A 1.711 0.99
252_A 293_V 1.71 0.99
24_S 186_D 1.696 0.99
319_H 322_N 1.691 0.99
57_V 261_L 1.684 0.99
199_E 243_A 1.68 0.99
201_A 236_V 1.68 0.99
61_T 175_A 1.671 0.99
290_Y 313_A 1.668 0.99
199_E 242_A 1.661 0.99
231_E 277_F 1.634 0.99
70_G 107_L 1.633 0.99
325_K 328_V 1.611 0.99
252_A 258_V 1.592 0.99
189_L 297_V 1.592 0.99
54_D 249_R 1.576 0.99
199_E 246_R 1.57 0.99
51_N 196_K 1.538 0.98
101_P 107_L 1.537 0.98
295_A 342_F 1.528 0.98
82_V 91_I 1.513 0.98
50_L 198_V 1.512 0.98
120_T 130_E 1.498 0.98
72_K 105_A 1.489 0.98
31_L 315_A 1.487 0.98
27_R 330_E 1.46 0.98
236_V 239_A 1.459 0.97
234_Q 275_P 1.455 0.97
48_D 192_K 1.446 0.97
215_V 309_M 1.441 0.97
326_A 329_E 1.436 0.97
43_F 297_V 1.434 0.97
265_A 292_V 1.432 0.97
227_S 281_Q 1.425 0.97
94_H 126_L 1.413 0.97
17_H 153_I 1.406 0.97
258_V 293_V 1.403 0.97
240_V 273_I 1.402 0.97
187_E 194_R 1.4 0.97
33_G 314_F 1.398 0.97
8_F 282_I 1.39 0.96
320_T 343_I 1.381 0.96
258_V 296_L 1.378 0.96
62_R 170_S 1.374 0.96
41_G 48_D 1.373 0.96
46_L 297_V 1.371 0.96
31_L 343_I 1.364 0.96
30_S 344_T 1.36 0.96
263_S 280_T 1.359 0.96
14_L 328_V 1.358 0.96
90_R 128_E 1.345 0.95
224_I 281_Q 1.342 0.95
1_M 6_F 1.339 0.95
3_V 220_I 1.338 0.95
136_S 139_D 1.336 0.95
315_A 323_A 1.333 0.95
244_K 294_D 1.32 0.95
51_N 249_R 1.3 0.94
28_L 340_A 1.294 0.94
58_F 200_M 1.291 0.94
243_A 246_R 1.286 0.94
67_R 79_E 1.285 0.94
221_E 285_Y 1.284 0.94
237_V 273_I 1.276 0.93
60_N 172_K 1.271 0.93
121_A 128_E 1.26 0.93
109_L 117_A 1.256 0.93
26_C 43_F 1.255 0.93
95_I 129_V 1.25 0.92
31_L 323_A 1.248 0.92
253_V 297_V 1.245 0.92
295_A 344_T 1.243 0.92
97_A 100_A 1.243 0.92
20_M 25_S 1.225 0.91
50_L 251_I 1.223 0.91
308_I 320_T 1.222 0.91
244_K 292_V 1.22 0.91
46_L 189_L 1.219 0.91
51_N 54_D 1.218 0.91
315_A 320_T 1.215 0.91
117_A 131_F 1.209 0.91
86_L 128_E 1.209 0.91
174_G 206_H 1.206 0.91
237_V 241_L 1.205 0.91
84_R 279_D 1.204 0.91
187_E 191_E 1.202 0.90
85_M 138_L 1.192 0.90
69_F 146_H 1.191 0.90
80_V 109_L 1.189 0.90
192_K 196_K 1.189 0.90
55_L 201_A 1.185 0.90
232_V 264_A 1.183 0.89
3_V 304_E 1.175 0.89
241_L 272_L 1.164 0.88
124_G 127_F 1.16 0.88
239_A 243_A 1.159 0.88
155_R 337_Y 1.157 0.88
230_A 260_S 1.155 0.88
80_V 129_V 1.149 0.88
217_V 222_D 1.147 0.87
24_S 44_T 1.134 0.87
57_V 201_A 1.128 0.86
4_T 304_E 1.125 0.86
62_R 173_P 1.111 0.85
83_E 94_H 1.096 0.84
50_L 56_L 1.09 0.84
87_D 90_R 1.088 0.83
18_Y 155_R 1.086 0.83
192_K 195_A 1.083 0.83
55_L 199_E 1.082 0.83
328_V 331_K 1.075 0.82
296_L 311_V 1.072 0.82
55_L 248_N 1.071 0.82
83_E 209_A 1.064 0.82
31_L 320_T 1.062 0.81
312_S 317_Y 1.057 0.81
117_A 129_V 1.054 0.81
203_V 232_V 1.053 0.81
80_V 107_L 1.052 0.81
312_S 315_A 1.052 0.81
113_E 143_S 1.051 0.80
90_R 120_T 1.044 0.80
240_V 292_V 1.044 0.80
220_I 285_Y 1.038 0.79
58_F 190_L 1.034 0.79
302_L 335_F 1.034 0.79
161_D 337_Y 1.029 0.78
20_M 24_S 1.027 0.78
326_A 330_E 1.019 0.78
5_D 317_Y 1.015 0.77
29_L 326_A 1.014 0.77
260_S 264_A 1.01 0.77
177_A 180_T 1.008 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1yy3A20.95221000.029Contact Map0.747
1wdiA10.93821000.034Contact Map0.709
1vkyA20.93821000.037Contact Map0.843
3tj8A20.466322.30.979Contact Map0.254
1ds1A10.306219.60.98Contact Map0.342
1gmuA40.398918.20.98Contact Map0.253
1earA10.412917.80.98Contact Map0.208
4bluA20.530914.30.981Contact Map0.244
2wbqA10.29789.30.983Contact Map0.606
1pxfA10.28659.10.983Contact Map0.097
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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