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OPENSEQ.org
PYRG - CTP synthase
UniProt: P0A7E5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10810
Length: 545 (539)
Sequences: 1578
Seq/Len: 2.93
PYRG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
366_R 370_E 4.695 1.00
457_L 531_G 4.553 1.00
293_G 344_L 4.458 1.00
291_T 324_N 4.154 1.00
289_E 324_N 4.016 1.00
365_A 384_V 3.764 1.00
291_T 326_K 3.697 1.00
398_N 410_Y 3.659 1.00
292_I 346_A 3.437 1.00
363_T 366_R 3.367 1.00
372_N 507_P 3.343 1.00
165_G 168_H 3.278 1.00
365_A 375_Y 3.174 1.00
365_A 509_F 3.151 1.00
443_A 464_V 3.124 1.00
454_V 500_I 3.067 1.00
25_L 260_I 3.022 1.00
326_K 344_L 3.016 1.00
479_K 483_D 2.919 1.00
396_M 480_Q 2.69 1.00
326_K 343_G 2.619 1.00
487_R 504_P 2.615 1.00
500_I 514_F 2.576 1.00
453_L 456_Q 2.543 1.00
384_V 387_I 2.54 1.00
246_K 284_A 2.507 1.00
455_R 461_P 2.451 1.00
452_S 487_R 2.448 1.00
372_N 505_N 2.368 1.00
347_I 368_A 2.367 1.00
252_K 257_D 2.361 1.00
121_N 125_E 2.36 1.00
170_L 207_I 2.353 1.00
181_A 213_D 2.341 1.00
293_G 328_I 2.338 1.00
389_Y 393_V 2.332 1.00
450_D 455_R 2.26 1.00
242_D 246_K 2.257 1.00
396_M 410_Y 2.257 1.00
452_S 489_A 2.248 1.00
34_L 136_V 2.243 1.00
375_Y 385_A 2.234 1.00
316_G 323_V 2.215 1.00
21_A 209_I 2.195 1.00
321_V 537_S 2.186 1.00
124_K 163_E 2.179 1.00
408_C 411_P 2.171 1.00
233_K 262_K 2.119 1.00
171_F 203_I 2.105 1.00
398_N 409_K 2.093 1.00
97_S 101_R 2.073 1.00
410_Y 477_L 2.072 1.00
349_V 375_Y 2.069 1.00
99_V 119_I 2.029 1.00
287_V 320_R 2.007 1.00
222_A 232_E 1.988 1.00
481_I 486_L 1.95 0.99
401_S 404_F 1.927 0.99
207_I 256_L 1.919 0.99
309_I 327_L 1.896 0.99
98_D 122_A 1.895 0.99
453_L 510_V 1.888 0.99
288_S 321_V 1.883 0.99
160_M 164_I 1.881 0.99
454_V 489_A 1.874 0.99
492_S 495_D 1.867 0.99
385_A 509_F 1.867 0.99
86_R 94_R 1.858 0.99
398_N 405_V 1.842 0.99
81_R 524_D 1.838 0.99
396_M 477_L 1.837 0.99
319_N 534_K 1.831 0.99
457_L 510_V 1.83 0.99
473_V 481_I 1.82 0.99
197_E 200_S 1.787 0.99
449_V 482_E 1.784 0.99
218_A 222_A 1.78 0.99
359_E 362_I 1.78 0.99
480_Q 483_D 1.78 0.99
289_E 322_S 1.776 0.99
56_Q 111_A 1.773 0.99
122_A 125_E 1.766 0.99
358_V 384_V 1.752 0.99
177_V 216_V 1.744 0.99
64_E 443_A 1.73 0.98
402_T 411_P 1.714 0.98
64_E 83_K 1.71 0.98
348_L 532_F 1.706 0.98
534_K 538_E 1.668 0.98
136_V 264_F 1.662 0.98
249_G 277_E 1.646 0.98
400_N 405_V 1.626 0.98
334_E 337_G 1.618 0.97
30_E 81_R 1.617 0.97
282_E 320_R 1.614 0.97
208_L 224_I 1.609 0.97
475_N 498_V 1.598 0.97
99_V 108_Y 1.574 0.97
449_V 487_R 1.561 0.97
141_I 157_I 1.56 0.97
258_D 262_K 1.558 0.97
492_S 496_Q 1.54 0.96
394_A 481_I 1.537 0.96
39_M 139_V 1.528 0.96
128_L 160_M 1.524 0.96
443_A 519_T 1.521 0.96
389_Y 484_A 1.512 0.96
154_L 201_I 1.51 0.96
15_S 183_S 1.51 0.96
508_W 532_F 1.509 0.96
413_V 473_V 1.508 0.96
386_L 412_V 1.503 0.96
30_E 82_T 1.498 0.95
346_A 532_F 1.487 0.95
31_A 273_L 1.464 0.95
358_V 404_F 1.453 0.94
448_L 452_S 1.45 0.94
405_V 408_C 1.446 0.94
454_V 510_V 1.441 0.94
366_R 392_H 1.436 0.94
255_G 258_D 1.435 0.94
5_Y 131_G 1.429 0.94
64_E 519_T 1.428 0.94
92_T 119_I 1.427 0.94
386_L 501_I 1.419 0.93
346_A 536_A 1.419 0.93
450_D 461_P 1.402 0.93
237_S 254_Q 1.395 0.93
445_Q 462_T 1.392 0.92
375_Y 509_F 1.386 0.92
167_E 265_S 1.382 0.92
206_D 263_R 1.38 0.92
128_L 164_I 1.373 0.92
45_I 92_T 1.371 0.92
175_T 191_T 1.368 0.92
157_I 171_F 1.365 0.92
242_D 284_A 1.363 0.91
125_E 129_E 1.361 0.91
457_L 508_W 1.354 0.91
8_V 138_L 1.331 0.90
234_A 259_Y 1.33 0.90
21_A 174_L 1.327 0.90
291_T 343_G 1.325 0.90
136_V 261_C 1.316 0.89
372_N 506_H 1.316 0.89
358_V 380_L 1.304 0.89
375_Y 384_V 1.304 0.89
329_D 332_D 1.301 0.89
196_K 200_S 1.289 0.88
386_L 473_V 1.288 0.88
478_L 491_R 1.287 0.88
348_L 378_I 1.28 0.88
291_T 344_L 1.274 0.87
475_N 478_L 1.273 0.87
448_L 490_G 1.264 0.87
257_D 271_A 1.264 0.87
127_V 160_M 1.257 0.86
376_L 510_V 1.257 0.86
98_D 126_R 1.251 0.86
473_V 478_L 1.251 0.86
300_E 329_D 1.25 0.86
163_E 171_F 1.248 0.86
195_V 205_P 1.238 0.85
281_F 285_N 1.218 0.84
446_C 490_G 1.211 0.83
386_L 481_I 1.205 0.83
212_S 237_S 1.204 0.83
162_V 229_N 1.203 0.83
447_Q 462_T 1.193 0.82
333_V 340_I 1.192 0.82
293_G 345_D 1.191 0.82
380_L 404_F 1.188 0.82
508_W 531_G 1.188 0.82
311_A 315_G 1.187 0.82
27_A 30_E 1.179 0.81
6_I 170_L 1.174 0.81
45_I 119_I 1.166 0.80
81_R 521_T 1.166 0.80
419_W 432_K 1.159 0.80
39_M 49_P 1.159 0.80
479_K 482_E 1.157 0.79
131_G 137_V 1.157 0.79
348_L 368_A 1.156 0.79
41_L 75_H 1.156 0.79
400_N 408_C 1.153 0.79
480_Q 484_A 1.152 0.79
349_V 385_A 1.15 0.79
186_V 217_P 1.139 0.78
4_N 264_F 1.139 0.78
236_I 259_Y 1.135 0.78
22_A 138_L 1.131 0.77
161_A 169_T 1.126 0.77
365_A 388_D 1.125 0.77
212_S 239_K 1.123 0.77
41_L 49_P 1.121 0.76
288_S 537_S 1.121 0.76
109_L 435_L 1.12 0.76
446_C 514_F 1.119 0.76
394_A 480_Q 1.119 0.76
38_I 80_I 1.119 0.76
385_A 501_I 1.119 0.76
486_L 501_I 1.115 0.76
394_A 486_L 1.113 0.76
491_R 495_D 1.11 0.75
457_L 532_F 1.109 0.75
90_F 126_R 1.108 0.75
218_A 232_E 1.104 0.75
448_L 454_V 1.102 0.75
318_K 525_G 1.102 0.75
339_E 342_K 1.101 0.74
121_N 222_A 1.101 0.74
382_M 473_V 1.094 0.74
396_M 409_K 1.089 0.73
455_R 459_N 1.088 0.73
20_I 247_I 1.079 0.72
253_S 277_E 1.078 0.72
382_M 501_I 1.071 0.72
173_H 194_S 1.071 0.72
102_K 107_D 1.07 0.71
292_I 536_A 1.069 0.71
294_M 308_V 1.064 0.71
98_D 102_K 1.063 0.71
359_E 391_R 1.061 0.71
376_L 532_F 1.058 0.70
37_T 88_N 1.051 0.70
212_S 216_V 1.049 0.69
530_A 534_K 1.048 0.69
348_L 361_M 1.044 0.69
221_R 254_Q 1.042 0.69
170_L 263_R 1.04 0.68
217_P 220_E 1.039 0.68
385_A 511_A 1.038 0.68
55_I 300_E 1.036 0.68
16_L 21_A 1.036 0.68
252_K 271_A 1.035 0.68
342_K 371_N 1.035 0.68
308_V 351_G 1.031 0.67
388_D 392_H 1.03 0.67
154_L 203_I 1.027 0.67
278_Q 282_E 1.025 0.67
21_A 238_L 1.023 0.66
277_E 281_F 1.023 0.66
283_E 317_L 1.018 0.66
41_L 127_V 1.01 0.65
246_K 280_I 1.008 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nvaA20.96881000.358Contact Map0.8
1vcoA10.9781000.371Contact Map0.74
1s1mA211000.398Contact Map0.772
2c5mA40.48811000.474Contact Map0.768
2v4uA10.49361000.79Contact Map0.74
2w7tA10.46241000.815Contact Map0.748
1l9xA40.44951000.898Contact Map0.473
3uowA20.420299.90.902Contact Map0.441
3fijA80.398299.90.907Contact Map0.688
1gpmA40.370699.90.91Contact Map0.49
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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