OPENSEQ.org - HSLV - ECOLI GREMLIN

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HSLV - ATP-dependent protease subunit HslV

UniProt:	P0A7B8	Sequence MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11676
Length:	176 (174)
Sequences:	644
Seq/Len:	3.70

HSLV
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
144_S	147_E	4.18	1.00
146_R	150_E	4.101	1.00
16_A	149_A	3.781	1.00
158_D	165_H	3.777	1.00
146_R	171_E	3.377	1.00
140_N	151_K	3.235	1.00
51_T	112_D	3.067	1.00
4_I	17_G	2.826	1.00
12_H	171_E	2.685	1.00
60_L	82_D	2.534	1.00
44_I	172_L	2.317	1.00
21_A	32_V	2.305	1.00
131_Q	135_R	2.194	1.00
97_A	121_I	2.181	1.00
45_A	58_F	2.048	1.00
22_T	161_I	2.007	1.00
97_A	104_S	1.983	1.00
16_A	153_L	1.976	1.00
106_I	121_I	1.847	1.00
139_E	151_K	1.837	1.00
150_E	154_D	1.825	0.99
118_N	135_R	1.786	0.99
16_A	167_H	1.741	0.99
157_G	165_H	1.737	0.99
40_N	66_E	1.682	0.99
6_S	104_S	1.677	0.99
13_V	104_S	1.638	0.99
97_A	120_L	1.631	0.99
26_T	159_I	1.629	0.99
9_R	141_T	1.601	0.98
154_D	165_H	1.59	0.98
104_S	121_I	1.589	0.98
87_R	91_K	1.587	0.98
8_R	104_S	1.576	0.98
139_E	158_D	1.557	0.98
37_R	170_E	1.547	0.98
149_A	152_A	1.527	0.98
64_K	82_D	1.526	0.97
56_T	59_E	1.518	0.97
76_A	105_L	1.514	0.97
135_R	158_D	1.475	0.97
23_L	95_L	1.437	0.96
42_K	101_E	1.392	0.95
61_F	98_V	1.38	0.95
73_V	103_A	1.378	0.95
30_G	117_E	1.365	0.94
76_A	107_I	1.346	0.94
42_K	100_D	1.346	0.94
43_V	75_A	1.34	0.94
157_G	167_H	1.338	0.94
38_L	58_F	1.328	0.93
51_T	54_A	1.323	0.93
22_T	26_T	1.323	0.93
9_R	138_L	1.299	0.92
5_V	134_A	1.256	0.90
151_K	154_D	1.245	0.90
12_H	173_S	1.243	0.90
37_R	41_D	1.226	0.89
12_H	144_S	1.224	0.89
154_D	157_G	1.206	0.88
28_M	114_V	1.202	0.88
45_A	98_V	1.19	0.87
128_P	131_Q	1.172	0.86
71_H	117_E	1.158	0.85
95_L	114_V	1.157	0.85
39_Y	70_G	1.157	0.85
97_A	106_I	1.133	0.83
108_T	114_V	1.131	0.83
73_V	105_L	1.124	0.82
1_M	168_T	1.123	0.82
23_L	28_M	1.083	0.79
1_M	51_T	1.068	0.78
115_Q	119_D	1.05	0.76
16_A	169_I	1.033	0.74
60_L	63_R	1.018	0.73
1_M	4_I	1.012	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1g3kA	3	0.983	100	0.642	Contact Map	0.756
1m4yA	3	0.9716	100	0.659	Contact Map	0.762
2z3bA	12	0.983	100	0.671	Contact Map	0.74
4hnzA	12	0.9886	100	0.684	Contact Map	0.741
1iruN	2	0.983	99.9	0.734	Contact Map	0.452
1iruJ	2	0.983	99.9	0.736	Contact Map	0.425
1rypJ	2	0.9773	99.9	0.736	Contact Map	0.458
1g0uM	2	0.983	99.9	0.74	Contact Map	0.495
1rypH	2	0.9773	99.9	0.74	Contact Map	0.498
1rypN	2	0.983	99.9	0.741	Contact Map	0.499

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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