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OPENSEQ.org
PDXJ - Pyridoxine 5'-phosphate synthase
UniProt: P0A794 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10693
Length: 243 (238)
Sequences: 849
Seq/Len: 3.57
PDXJ
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_R 85_E 4.735 1.00
18_N 54_T 3.76 1.00
142_K 181_F 3.112 1.00
35_E 67_T 2.477 1.00
219_I 227_L 2.469 1.00
136_A 178_A 2.354 1.00
160_A 199_N 2.242 1.00
183_A 208_E 2.186 1.00
113_R 146_E 2.153 1.00
44_V 58_V 2.149 1.00
40_D 235_K 2.072 1.00
76_T 79_M 2.056 1.00
229_D 233_E 2.043 1.00
56_R 60_I 2.013 1.00
121_K 125_D 1.968 1.00
145_A 185_L 1.967 1.00
124_A 150_P 1.918 1.00
75_V 119_A 1.812 0.99
7_G 213_N 1.803 0.99
171_E 174_R 1.794 0.99
154_I 175_I 1.786 0.99
84_V 122_R 1.775 0.99
181_F 184_S 1.745 0.99
120_C 124_A 1.729 0.99
141_I 152_I 1.708 0.99
80_L 119_A 1.655 0.99
225_T 229_D 1.648 0.99
77_E 81_A 1.636 0.98
75_V 116_M 1.623 0.98
110_A 139_E 1.606 0.98
138_E 181_F 1.594 0.98
120_C 147_V 1.585 0.98
16_L 223_V 1.56 0.98
159_Y 202_A 1.559 0.98
180_T 208_E 1.557 0.98
173_A 177_K 1.539 0.97
113_R 147_V 1.538 0.97
43_T 70_N 1.511 0.97
142_K 185_L 1.509 0.97
142_K 146_E 1.504 0.97
228_K 232_A 1.489 0.97
41_G 90_F 1.487 0.97
182_A 189_V 1.483 0.97
129_Q 151_F 1.478 0.97
91_C 123_L 1.469 0.96
188_K 210_H 1.447 0.96
4_L 238_M 1.444 0.96
134_I 141_I 1.433 0.96
90_F 129_Q 1.406 0.95
142_K 145_A 1.406 0.95
179_A 208_E 1.405 0.95
77_E 122_R 1.386 0.95
172_L 202_A 1.379 0.94
100_E 105_G 1.376 0.94
36_Q 228_K 1.344 0.93
80_L 122_R 1.318 0.92
13_I 223_V 1.308 0.92
90_F 151_F 1.301 0.92
172_L 206_I 1.298 0.92
62_R 89_H 1.293 0.91
91_C 128_I 1.285 0.91
74_A 98_R 1.279 0.91
84_V 128_I 1.277 0.91
7_G 43_T 1.276 0.91
175_I 209_M 1.275 0.91
221_R 225_T 1.262 0.90
44_V 61_L 1.258 0.90
159_Y 200_V 1.236 0.89
233_E 236_R 1.227 0.88
181_F 185_L 1.213 0.88
84_V 126_A 1.209 0.87
229_D 232_A 1.207 0.87
74_A 79_M 1.204 0.87
139_E 142_K 1.196 0.87
44_V 69_M 1.19 0.86
119_A 122_R 1.19 0.86
120_C 130_V 1.184 0.86
44_V 90_F 1.184 0.86
237_L 240_E 1.183 0.86
203_I 212_L 1.173 0.85
33_I 228_K 1.173 0.85
221_R 233_E 1.169 0.85
101_V 135_D 1.169 0.85
32_F 64_T 1.168 0.85
138_E 142_K 1.166 0.85
24_Y 196_T 1.164 0.84
225_T 233_E 1.161 0.84
200_V 212_L 1.154 0.84
31_A 42_I 1.148 0.83
92_C 150_P 1.146 0.83
236_R 240_E 1.142 0.83
34_A 42_I 1.139 0.83
132_L 147_V 1.138 0.83
113_R 117_R 1.131 0.82
28_V 60_I 1.131 0.82
141_I 178_A 1.129 0.82
235_K 239_L 1.123 0.81
80_L 123_L 1.113 0.81
138_E 177_K 1.099 0.80
169_A 173_A 1.088 0.79
13_I 30_A 1.087 0.78
60_I 64_T 1.084 0.78
201_K 237_L 1.081 0.78
18_N 21_G 1.075 0.77
141_I 181_F 1.074 0.77
59_R 82_I 1.072 0.77
8_V 218_I 1.07 0.77
201_K 240_E 1.068 0.77
176_A 206_I 1.067 0.77
41_G 68_R 1.067 0.77
177_K 180_T 1.06 0.76
65_L 69_M 1.059 0.76
32_F 36_Q 1.058 0.76
26_D 60_I 1.05 0.75
35_E 68_R 1.049 0.75
154_I 179_A 1.047 0.75
117_R 147_V 1.047 0.75
172_L 176_A 1.045 0.75
173_A 176_A 1.045 0.75
129_Q 210_H 1.04 0.74
164_T 167_E 1.038 0.74
43_T 213_N 1.035 0.74
114_D 117_R 1.03 0.73
116_M 119_A 1.028 0.73
136_A 154_I 1.026 0.73
5_L 68_R 1.024 0.72
91_C 97_K 1.023 0.72
112_Q 115_K 1.018 0.72
58_V 71_L 1.017 0.72
29_Q 32_F 1.016 0.72
143_A 147_V 1.013 0.71
77_E 115_K 1.01 0.71
132_L 144_A 1.01 0.71
59_R 86_T 1.007 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1m5wA811000.009Contact Map0.844
3gk0A811000.014Contact Map0.792
3o6cA10.97531000.041Contact Map0.717
1h1yA20.8642980.913Contact Map0.563
2fliA120.85697.90.916Contact Map0.586
2ekcA20.876597.70.92Contact Map0.493
1rd5A20.89397.60.92Contact Map0.547
1tqjA60.872497.60.92Contact Map0.54
4gj1A10.872497.60.921Contact Map0.526
1xm3A40.905397.60.921Contact Map0.544
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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