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OPENSEQ.org
GLSA2 - Glutaminase 2
UniProt: P0A6W0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13816
Length: 308 (303)
Sequences: 692
Seq/Len: 2.28
GLSA2
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GLSA1 GLSA2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
154_D 199_K 4.761 1.00
40_R 60_E 3.518 1.00
166_A 173_W 3.486 1.00
144_G 223_E 3.349 1.00
148_V 204_E 3.156 1.00
79_H 137_R 2.599 1.00
46_C 206_A 2.535 1.00
71_L 208_T 2.498 1.00
42_G 202_C 2.415 1.00
165_S 193_F 2.402 1.00
217_K 224_P 2.392 1.00
25_K 28_D 2.324 1.00
89_V 123_V 2.116 1.00
61_R 204_E 2.045 0.99
12_N 302_Q 2.007 0.99
46_C 52_L 1.992 0.99
256_L 268_A 1.917 0.99
41_L 295_V 1.878 0.99
92_D 245_Q 1.871 0.99
16_Q 298_Q 1.838 0.98
27_A 30_I 1.835 0.98
15_R 18_R 1.828 0.98
54_Q 58_A 1.815 0.98
72_S 138_M 1.806 0.98
246_N 284_D 1.802 0.98
52_L 206_A 1.774 0.98
14_L 41_L 1.763 0.98
59_Q 203_V 1.74 0.98
64_I 68_S 1.727 0.97
209_F 267_V 1.712 0.97
121_L 193_F 1.665 0.97
27_A 262_V 1.649 0.96
7_N 11_E 1.637 0.96
44_A 203_V 1.631 0.96
68_S 195_Y 1.59 0.95
189_L 193_F 1.583 0.95
171_I 174_L 1.577 0.95
52_L 203_V 1.575 0.95
239_A 251_A 1.572 0.95
162_F 165_S 1.542 0.94
14_L 55_A 1.538 0.94
171_I 175_M 1.521 0.93
67_I 265_G 1.517 0.93
32_A 156_V 1.5 0.93
253_R 297_E 1.491 0.93
129_G 183_H 1.488 0.92
74_V 211_F 1.48 0.92
48_V 214_N 1.475 0.92
141_V 145_L 1.47 0.92
280_S 291_A 1.47 0.92
138_M 195_Y 1.467 0.92
11_E 15_R 1.467 0.92
268_A 296_L 1.458 0.91
67_I 205_L 1.441 0.91
123_V 185_V 1.441 0.91
278_V 292_G 1.426 0.90
36_V 40_R 1.402 0.89
162_F 193_F 1.398 0.89
218_A 221_I 1.394 0.89
167_R 177_S 1.391 0.89
142_V 151_I 1.374 0.88
166_A 176_K 1.366 0.87
94_S 116_I 1.345 0.86
85_I 126_M 1.322 0.85
29_Y 262_V 1.316 0.85
43_I 55_A 1.311 0.84
159_R 163_E 1.305 0.84
210_V 219_I 1.299 0.84
270_V 274_M 1.284 0.83
32_A 35_T 1.282 0.83
54_Q 59_Q 1.282 0.83
122_V 180_N 1.28 0.82
57_D 60_E 1.27 0.82
31_P 160_S 1.268 0.82
9_I 302_Q 1.254 0.81
61_R 201_S 1.249 0.80
27_A 34_A 1.24 0.80
282_E 291_A 1.228 0.79
92_D 95_G 1.225 0.78
143_R 151_I 1.221 0.78
29_Y 33_L 1.215 0.78
155_T 194_H 1.207 0.77
162_F 190_Q 1.2 0.76
93_P 241_S 1.199 0.76
256_L 300_T 1.198 0.76
205_L 277_A 1.197 0.76
243_M 258_A 1.196 0.76
30_I 33_L 1.176 0.74
32_A 160_S 1.176 0.74
104_L 111_P 1.175 0.74
147_G 150_D 1.165 0.73
93_P 245_Q 1.161 0.73
121_L 162_F 1.156 0.73
74_V 145_L 1.148 0.72
72_S 195_Y 1.145 0.72
42_G 57_D 1.138 0.71
246_N 293_I 1.137 0.71
208_T 212_L 1.133 0.70
47_T 51_Q 1.126 0.70
121_L 189_L 1.124 0.70
93_P 104_L 1.12 0.69
44_A 54_Q 1.118 0.69
165_S 189_L 1.118 0.69
258_A 268_A 1.113 0.68
27_A 33_L 1.112 0.68
43_I 295_V 1.11 0.68
61_R 181_F 1.109 0.68
294_A 298_Q 1.103 0.67
81_S 85_I 1.098 0.67
63_S 157_V 1.096 0.67
269_I 275_A 1.091 0.66
105_E 109_G 1.087 0.66
14_L 18_R 1.085 0.66
73_L 86_W 1.077 0.65
111_P 161_E 1.067 0.64
181_F 195_Y 1.061 0.63
271_P 280_S 1.059 0.63
31_P 164_H 1.058 0.63
218_A 225_V 1.05 0.62
76_A 254_V 1.049 0.62
161_E 262_V 1.048 0.62
26_V 34_A 1.046 0.61
64_I 263_G 1.04 0.61
136_Q 140_E 1.04 0.61
35_T 156_V 1.031 0.60
63_S 115_F 1.021 0.59
184_D 187_T 1.018 0.58
298_Q 302_Q 1.018 0.58
26_V 38_G 1.018 0.58
78_R 230_Q 1.016 0.58
30_I 161_E 1.012 0.58
294_A 297_E 1.009 0.57
123_V 202_C 1.009 0.57
11_E 55_A 1.005 0.57
183_H 188_V 1.001 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pbyA40.99681000.029Contact Map0.761
1u60A40.99351000.031Contact Map0.723
3uo9A40.99031000.042Contact Map0.725
1mkiA20.9871000.045Contact Map0.649
4bqmA20.99031000.046Contact Map0.612
3agdA20.9871000.079Contact Map0.675
1ghpA10.740398.70.918Contact Map0.511
4dxbA20.840998.40.925Contact Map0.499
1e25A10.782598.20.929Contact Map0.424
2qmiA80.8864980.932Contact Map0.512
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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