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OPENSEQ.org
GAL1 - Galactokinase
UniProt: P0A6T3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10363
Length: 382 (376)
Sequences: 1855
Seq/Len: 4.93
GAL1
Paralog alert: 0.25 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_Q 51_Q 3.812 1.00
65_R 114_D 3.146 1.00
52_T 132_S 3.13 1.00
295_A 320_K 3.127 1.00
286_D 289_R 3.07 1.00
301_M 307_I 2.889 1.00
197_K 283_E 2.83 1.00
329_V 342_A 2.543 1.00
57_A 114_D 2.489 1.00
278_A 290_M 2.48 1.00
150_D 153_Q 2.47 1.00
354_Q 358_E 2.461 1.00
216_R 334_G 2.422 1.00
273_A 277_E 2.39 1.00
233_G 265_V 2.376 1.00
56_C 140_V 2.328 1.00
25_A 379_A 2.311 1.00
312_I 340_I 2.24 1.00
267_H 300_S 2.203 1.00
227_R 231_E 2.144 1.00
12_A 18_P 2.123 1.00
289_R 292_E 2.085 1.00
204_G 346_E 2.053 1.00
246_T 249_E 1.964 1.00
54_I 136_A 1.96 1.00
188_L 279_A 1.942 1.00
62_R 81_D 1.941 1.00
117_I 133_L 1.926 1.00
266_R 304_D 1.917 1.00
40_D 241_A 1.905 1.00
321_A 359_Q 1.902 1.00
292_E 296_E 1.888 1.00
169_N 224_N 1.877 1.00
210_I 342_A 1.874 1.00
59_R 114_D 1.866 1.00
232_T 235_R 1.833 1.00
142_Q 148_P 1.823 1.00
23_I 143_Q 1.821 1.00
206_A 346_E 1.82 1.00
10_L 14_A 1.812 1.00
277_E 289_R 1.804 1.00
63_K 77_E 1.797 1.00
135_V 179_A 1.783 1.00
270_T 304_D 1.77 1.00
280_S 284_Q 1.767 1.00
344_I 352_V 1.72 1.00
281_A 286_D 1.718 1.00
361_E 367_K 1.714 1.00
30_N 45_P 1.703 1.00
358_E 362_A 1.7 0.99
39_N 230_C 1.673 0.99
298_H 316_V 1.67 0.99
377_Q 380_G 1.655 0.99
155_A 179_A 1.603 0.99
222_E 225_T 1.592 0.99
264_R 306_E 1.548 0.99
28_R 37_D 1.548 0.99
65_R 77_E 1.523 0.99
213_N 369_T 1.503 0.98
17_Y 57_A 1.503 0.98
21_H 381_Q 1.5 0.98
299_A 320_K 1.493 0.98
168_C 334_G 1.485 0.98
318_I 359_Q 1.483 0.98
136_A 140_V 1.464 0.98
232_T 236_F 1.458 0.98
40_D 243_R 1.45 0.98
208_V 352_V 1.447 0.98
23_I 381_Q 1.437 0.98
214_F 309_V 1.433 0.98
329_V 340_I 1.413 0.97
308_T 331_M 1.404 0.97
294_M 341_V 1.401 0.97
10_L 13_N 1.396 0.97
35_H 38_Y 1.395 0.97
294_M 343_L 1.385 0.97
139_T 379_A 1.384 0.97
345_P 348_L 1.382 0.97
182_K 185_H 1.371 0.97
297_S 300_S 1.361 0.97
355_A 359_Q 1.356 0.97
30_N 34_E 1.355 0.97
229_Q 264_R 1.35 0.96
138_G 154_I 1.348 0.96
36_T 39_N 1.348 0.96
159_Q 172_I 1.348 0.96
64_V 112_G 1.33 0.96
99_V 138_G 1.326 0.96
291_G 328_G 1.324 0.96
318_I 322_V 1.315 0.96
301_M 312_I 1.302 0.95
20_T 58_P 1.296 0.95
8_Q 19_A 1.296 0.95
119_G 132_S 1.288 0.95
162_E 171_G 1.283 0.95
281_A 289_R 1.28 0.95
316_V 329_V 1.278 0.95
319_V 352_V 1.269 0.94
111_G 145_Y 1.262 0.94
70_D 118_S 1.256 0.94
68_A 71_Y 1.243 0.94
317_E 321_A 1.235 0.93
59_R 112_G 1.234 0.93
273_A 276_V 1.232 0.93
259_P 263_K 1.232 0.93
212_S 315_L 1.229 0.93
62_R 79_S 1.227 0.93
23_I 54_I 1.22 0.93
315_L 340_I 1.215 0.93
349_V 353_Q 1.212 0.93
29_V 341_V 1.201 0.92
143_Q 381_Q 1.193 0.92
21_H 143_Q 1.188 0.92
56_C 144_L 1.184 0.91
142_Q 147_L 1.179 0.91
29_V 48_I 1.176 0.91
299_A 303_D 1.168 0.91
279_A 283_E 1.163 0.90
106_R 160_E 1.162 0.90
25_A 136_A 1.157 0.90
182_K 377_Q 1.148 0.90
56_C 113_V 1.14 0.89
187_L 198_A 1.14 0.89
22_T 55_S 1.139 0.89
182_K 198_A 1.136 0.89
159_Q 170_C 1.135 0.89
131_A 170_C 1.131 0.89
217_T 220_G 1.129 0.89
210_I 340_I 1.128 0.88
12_A 16_G 1.126 0.88
34_E 301_M 1.12 0.88
162_E 167_G 1.115 0.88
43_V 173_M 1.113 0.88
260_I 263_K 1.112 0.88
314_T 364_T 1.106 0.87
168_C 218_L 1.101 0.87
11_F 57_A 1.099 0.87
27_G 121_V 1.097 0.87
171_G 175_Q 1.096 0.86
298_H 312_I 1.095 0.86
266_R 270_T 1.091 0.86
348_L 351_A 1.09 0.86
293_L 297_S 1.087 0.86
350_P 354_Q 1.087 0.86
253_V 256_E 1.087 0.86
155_A 159_Q 1.085 0.86
229_Q 261_V 1.081 0.85
239_Q 249_E 1.081 0.85
8_Q 12_A 1.077 0.85
332_T 339_C 1.077 0.85
357_A 368_E 1.074 0.85
36_T 257_L 1.073 0.85
41_G 98_G 1.072 0.85
172_I 176_L 1.064 0.84
32_I 278_A 1.052 0.83
64_V 113_V 1.05 0.83
30_N 37_D 1.05 0.83
100_V 141_L 1.05 0.83
314_T 363_K 1.048 0.83
29_V 332_T 1.048 0.83
313_D 316_V 1.045 0.83
69_A 116_V 1.044 0.83
314_T 318_I 1.044 0.83
42_F 276_V 1.044 0.83
139_T 154_I 1.043 0.83
207_V 341_V 1.042 0.82
228_E 232_T 1.037 0.82
49_D 376_S 1.034 0.82
210_I 315_L 1.033 0.82
332_T 341_V 1.033 0.82
28_R 128_S 1.029 0.81
177_I 181_G 1.027 0.81
28_R 38_Y 1.026 0.81
210_I 319_V 1.023 0.81
225_T 228_E 1.023 0.81
271_E 274_R 1.02 0.81
9_S 13_N 1.018 0.80
117_I 137_V 1.016 0.80
134_E 159_Q 1.014 0.80
37_D 175_Q 1.013 0.80
288_K 292_E 1.013 0.80
333_G 337_G 1.013 0.80
54_I 140_V 1.012 0.80
280_S 283_E 1.006 0.79
353_Q 357_A 1.006 0.79
152_A 156_L 1.005 0.79
96_V 117_I 1.004 0.79
7_T 10_L 1.003 0.79
30_N 38_Y 1.003 0.79
322_V 355_A 1.001 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pieA10.99211000.228Contact Map0.714
3v2uC20.98431000.247Contact Map0.723
1wuuA40.97641000.269Contact Map0.777
2a2cA10.98951000.28Contact Map0.693
2cz9A10.91621000.306Contact Map0.703
1kvkA10.86391000.43Contact Map0.579
4n3oA20.84291000.457Contact Map0.607
3k85A20.84821000.466Contact Map0.624
2hfsA20.84291000.478Contact Map0.684
1kkhA10.80631000.483Contact Map0.659
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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