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CYSC - Adenylyl-sulfate kinase
UniProt: P0A6J1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10185
Length: 201 (196)
Sequences: 1342
Seq/Len: 6.85

CYSC
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
140_E 152_R 4.603 1.00
138_I 141_A 4.419 1.00
90_G 118_V 3.483 1.00
111_H 164_S 3.04 1.00
60_Y 98_E 2.998 1.00
116_Q 120_E 2.858 1.00
30_V 122_V 2.788 1.00
133_D 175_H 2.774 1.00
158_N 163_D 2.744 1.00
24_H 58_S 2.691 1.00
157_R 163_D 2.545 1.00
31_L 130_V 2.506 1.00
33_F 104_L 2.504 1.00
180_Q 188_Q 2.294 1.00
48_L 189_L 2.275 1.00
135_P 178_G 2.201 1.00
17_V 126_R 2.155 1.00
78_S 81_D 2.123 1.00
134_T 139_C 2.04 1.00
89_V 107_F 2.037 1.00
47_A 182_V 2.033 1.00
112_R 170_E 2.002 1.00
180_Q 185_L 1.961 1.00
181_L 184_N 1.93 1.00
150_K 155_E 1.893 1.00
30_V 97_V 1.885 1.00
16_T 19_Q 1.855 1.00
57_V 102_V 1.85 1.00
71_L 92_V 1.813 1.00
79_D 164_S 1.794 1.00
67_V 89_V 1.779 1.00
176_L 185_L 1.744 1.00
133_D 177_N 1.727 1.00
149_K 153_A 1.726 1.00
51_A 187_Q 1.724 1.00
128_I 192_L 1.719 1.00
182_V 186_V 1.683 1.00
135_P 138_I 1.671 1.00
21_E 28_G 1.64 1.00
133_D 168_A 1.622 1.00
55_L 194_R 1.609 1.00
119_R 173_E 1.58 1.00
51_A 54_K 1.567 1.00
131_F 175_H 1.555 0.99
136_L 140_E 1.544 0.99
51_A 55_L 1.508 0.99
44_V 132_V 1.467 0.99
44_V 186_V 1.455 0.99
79_D 111_H 1.434 0.99
44_V 176_L 1.396 0.99
97_V 122_V 1.389 0.99
48_L 186_V 1.387 0.99
187_Q 191_D 1.382 0.99
26_H 57_V 1.34 0.98
96_M 101_L 1.34 0.98
32_W 109_S 1.336 0.98
84_E 87_R 1.309 0.98
76_G 81_D 1.288 0.97
112_R 116_Q 1.264 0.97
191_D 195_Q 1.256 0.97
37_S 108_I 1.251 0.97
174_I 192_L 1.215 0.96
176_L 189_L 1.208 0.96
17_V 21_E 1.181 0.95
67_V 107_F 1.163 0.94
116_Q 170_E 1.158 0.94
192_L 196_N 1.155 0.94
31_L 48_L 1.132 0.93
131_F 168_A 1.127 0.93
140_E 162_I 1.097 0.92
118_V 127_F 1.095 0.92
90_G 121_R 1.083 0.91
152_R 162_I 1.082 0.91
47_A 50_E 1.082 0.91
10_W 69_H 1.08 0.91
48_L 104_L 1.071 0.91
134_T 138_I 1.07 0.91
70_G 91_E 1.067 0.90
51_A 186_V 1.064 0.90
94_N 121_R 1.062 0.90
23_H 53_H 1.049 0.89
97_V 125_G 1.036 0.89
118_V 121_R 1.031 0.88
136_L 152_R 1.025 0.88
83_K 114_E 1.023 0.88
129_E 172_A 1.021 0.88
128_I 174_I 1.009 0.87
46_G 61_L 1.009 0.87
29_V 102_V 1.008 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1x6vB211000.431Contact Map0.839
2gksA211000.509Contact Map0.793
1m8pA311000.513Contact Map0.741
3cr8A311000.527Contact Map0.721
1m7gA40.98511000.533Contact Map0.86
2pezA20.87561000.598Contact Map0.892
2yvuA20.91041000.611Contact Map0.852
3uieA30.985199.90.642Contact Map0.852
1g8fA10.701599.90.696Contact Map0.653
1qhxA10.80199.80.728Contact Map0.657

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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