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OPENSEQ.org
PNCC - Nicotinamide-nucleotide amidohydrolase PncC
UniProt: P0A6G3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12698
Length: 165 (158)
Sequences: 2073
Seq/Len: 13.12
PNCC
Paralog alert: 0.30 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PNCC YDEJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_V 103_S 3.484 1.00
35_V 102_I 2.859 1.00
14_G 48_W 2.839 1.00
71_T 85_E 2.818 1.00
22_A 98_Y 2.75 1.00
68_R 85_E 2.609 1.00
71_T 82_V 2.474 1.00
121_W 135_R 2.274 1.00
80_E 84_V 2.261 1.00
18_K 47_A 2.249 1.00
69_E 73_A 2.237 1.00
62_A 69_E 2.142 1.00
25_T 96_A 2.038 1.00
22_A 97_D 1.985 1.00
32_G 40_T 1.956 1.00
38_V 150_T 1.897 1.00
121_W 133_T 1.827 1.00
34_W 150_T 1.772 1.00
75_H 81_P 1.771 1.00
91_L 125_A 1.734 1.00
37_K 41_D 1.728 1.00
111_G 114_E 1.701 1.00
141_D 144_A 1.696 1.00
155_Q 159_Q 1.674 1.00
72_L 77_A 1.656 1.00
124_F 156_T 1.655 1.00
51_R 94_A 1.646 1.00
36_A 54_V 1.633 1.00
51_R 63_Q 1.614 1.00
84_V 133_T 1.613 1.00
51_R 60_A 1.547 1.00
64_M 93_A 1.54 1.00
55_T 86_M 1.498 1.00
90_A 99_A 1.484 1.00
87_A 125_A 1.448 1.00
58_N 77_A 1.447 1.00
27_A 90_A 1.437 1.00
55_T 60_A 1.436 1.00
102_I 149_A 1.428 1.00
119_T 135_R 1.42 1.00
122_F 136_E 1.41 1.00
68_R 71_T 1.406 0.99
36_A 49_F 1.405 0.99
10_S 38_V 1.402 0.99
43_A 109_D 1.397 0.99
14_G 42_I 1.396 0.99
80_E 121_W 1.395 0.99
16_A 158_W 1.387 0.99
101_S 123_A 1.351 0.99
41_D 146_R 1.33 0.99
105_I 115_K 1.323 0.99
24_V 39_I 1.313 0.99
37_K 146_R 1.31 0.99
27_A 65_I 1.305 0.99
24_V 157_L 1.292 0.99
84_V 88_I 1.253 0.99
34_W 146_R 1.234 0.98
34_W 37_K 1.234 0.98
136_E 152_Y 1.203 0.98
39_I 49_F 1.201 0.98
63_Q 95_R 1.191 0.98
26_T 35_V 1.191 0.98
26_T 49_F 1.183 0.98
40_T 45_S 1.175 0.98
97_D 127_A 1.17 0.97
15_Q 19_A 1.158 0.97
155_Q 158_W 1.154 0.97
60_A 94_A 1.153 0.97
53_F 94_A 1.151 0.97
26_T 52_G 1.13 0.97
23_T 50_E 1.127 0.97
25_T 94_A 1.116 0.96
14_G 39_I 1.11 0.96
50_E 96_A 1.077 0.95
67_V 89_G 1.074 0.95
62_A 72_L 1.07 0.95
37_K 150_T 1.068 0.95
98_Y 126_T 1.039 0.94
88_I 131_G 1.037 0.94
80_E 135_R 1.032 0.94
17_L 22_A 1.025 0.93
98_Y 157_L 1.025 0.93
25_T 90_A 1.019 0.93
44_G 142_R 1.018 0.93
70_E 74_Q 1.013 0.93
23_T 97_D 1.013 0.93
53_F 90_A 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a9sA211000.006Contact Map0.847
1iwpG20.527311.50.944Contact Map0.258
3zdoA80.30919.60.946Contact Map0.234
1czaN10.9039.20.946Contact Map0.089
1eexG20.527390.946Contact Map0.188
2phnA20.89095.30.952Contact Map0.038
1ixrA20.92734.60.953Contact Map0.135
2a1jA10.37584.20.954Contact Map0.217
2ozlB20.51523.90.955Contact Map0.225
2ewtA10.41823.60.956Contact Map0.416
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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