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OPENSEQ.org
MOTA - Motility protein A
UniProt: P09348 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10601
Length: 295 (283)
Sequences: 1055
Seq/Len: 3.73
MOTA
Paralog alert: 0.30 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
151_I 242_K 3.407 1.00
169_G 221_S 2.679 1.00
88_K 100_D 2.661 1.00
9_V 43_G 2.299 1.00
17_G 36_I 2.215 1.00
185_V 207_V 2.17 1.00
88_K 96_S 2.115 1.00
24_S 186_H 2.025 1.00
41_G 168_V 1.988 1.00
10_V 218_G 1.915 1.00
46_I 54_I 1.911 1.00
215_L 220_I 1.895 1.00
103_N 106_E 1.875 1.00
119_D 238_M 1.853 1.00
166_A 224_A 1.839 1.00
41_G 172_L 1.828 0.99
30_Q 33_E 1.827 0.99
129_Y 245_L 1.777 0.99
147_M 245_L 1.696 0.99
144_E 148_D 1.693 0.99
187_A 206_M 1.684 0.99
3_I 226_V 1.67 0.99
158_A 234_T 1.666 0.99
82_L 257_A 1.652 0.99
33_E 208_G 1.644 0.99
194_P 197_E 1.644 0.99
126_I 241_V 1.626 0.99
48_G 225_T 1.62 0.98
122_M 241_V 1.614 0.98
51_G 55_K 1.579 0.98
165_L 223_L 1.567 0.98
3_I 64_L 1.565 0.98
174_A 206_M 1.555 0.98
38_A 215_L 1.546 0.98
11_L 219_F 1.529 0.98
181_V 202_I 1.527 0.98
247_S 260_F 1.481 0.97
57_T 164_S 1.477 0.97
3_I 47_V 1.472 0.97
128_D 150_E 1.467 0.97
243_V 264_T 1.464 0.97
144_E 243_V 1.445 0.96
214_L 218_G 1.442 0.96
151_I 235_S 1.438 0.96
8_L 12_G 1.432 0.96
74_M 77_D 1.422 0.96
198_L 202_I 1.421 0.96
177_I 202_I 1.413 0.96
244_T 261_G 1.399 0.95
278_E 282_A 1.384 0.95
108_E 111_A 1.376 0.95
187_A 202_I 1.347 0.94
202_I 206_M 1.341 0.94
80_A 258_V 1.338 0.94
177_I 208_G 1.336 0.94
158_A 231_S 1.328 0.93
60_A 161_P 1.317 0.93
177_I 187_A 1.31 0.93
154_H 158_A 1.301 0.92
57_T 165_L 1.296 0.92
18_Y 28_L 1.296 0.92
111_A 117_L 1.277 0.91
154_H 235_S 1.276 0.91
180_A 210_F 1.273 0.91
20_M 35_V 1.269 0.91
172_L 215_L 1.266 0.91
174_A 202_I 1.255 0.90
202_I 213_I 1.254 0.90
255_P 258_V 1.25 0.90
5_L 12_G 1.248 0.90
202_I 208_G 1.244 0.90
149_E 153_T 1.243 0.90
14_V 40_A 1.238 0.90
177_I 181_V 1.232 0.89
167_L 240_C 1.204 0.88
158_A 227_L 1.204 0.88
84_R 112_S 1.203 0.88
26_G 29_Y 1.182 0.87
12_G 15_F 1.178 0.86
62_P 66_R 1.178 0.86
27_A 189_G 1.177 0.86
55_K 59_K 1.148 0.84
21_T 206_M 1.145 0.84
142_E 252_Y 1.141 0.84
246_L 270_R 1.141 0.84
128_D 259_E 1.135 0.83
133_I 249_L 1.134 0.83
82_L 137_H 1.134 0.83
136_G 251_G 1.132 0.83
180_A 207_V 1.13 0.83
45_F 164_S 1.121 0.82
10_V 43_G 1.119 0.82
180_A 187_A 1.115 0.82
57_T 245_L 1.114 0.82
45_F 168_V 1.112 0.82
59_K 62_P 1.11 0.81
247_S 252_Y 1.11 0.81
44_S 171_S 1.108 0.81
116_I 126_I 1.107 0.81
5_L 9_V 1.104 0.81
28_L 186_H 1.1 0.81
168_V 220_I 1.1 0.81
33_E 177_I 1.098 0.81
175_F 201_L 1.097 0.80
180_A 188_L 1.091 0.80
43_G 88_K 1.09 0.80
216_A 221_S 1.09 0.80
18_Y 189_G 1.086 0.79
199_G 203_A 1.085 0.79
45_F 54_I 1.085 0.79
115_R 282_A 1.081 0.79
109_I 118_A 1.081 0.79
177_I 213_I 1.073 0.78
64_L 223_L 1.071 0.78
9_V 46_I 1.069 0.78
21_T 187_A 1.068 0.78
34_L 38_A 1.06 0.77
175_F 192_D 1.057 0.77
174_A 208_G 1.055 0.77
108_E 118_A 1.053 0.77
18_Y 23_G 1.051 0.76
150_E 270_R 1.051 0.76
18_Y 177_I 1.049 0.76
21_T 208_G 1.048 0.76
181_V 187_A 1.044 0.76
247_S 257_A 1.044 0.76
155_E 235_S 1.043 0.76
200_A 204_H 1.038 0.75
64_L 226_V 1.035 0.75
54_I 57_T 1.033 0.75
227_L 234_T 1.032 0.74
187_A 208_G 1.031 0.74
19_L 25_L 1.025 0.74
178_V 214_L 1.024 0.74
174_A 187_A 1.023 0.74
21_T 186_H 1.023 0.74
108_E 112_S 1.016 0.73
276_L 280_V 1.013 0.73
181_V 206_M 1.011 0.72
252_Y 260_F 1.011 0.72
246_L 250_N 1.01 0.72
139_N 142_E 1.009 0.72
123_L 282_A 1.008 0.72
30_Q 204_H 1.006 0.72
53_A 160_V 1.002 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4il3A20.8949650.957Contact Map0.219
4aw6A40.894937.60.963Contact Map0.229
2f05A10.3288310.965Contact Map0.443
2hepA10.257621.60.967Contact Map0.021
1i5pA10.518619.20.968Contact Map0.133
2czyA10.2508180.968Contact Map0.18
1e91A10.247517.10.969Contact Map0.135
1mhsA20.308515.70.969Contact Map0.119
3bhpA30.2034140.97Contact Map0
1g1eB10.26113.70.97Contact Map0.206
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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