| UniProt: | P09030 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11073 | ||
| Length: | 268 (262) | ||
| Sequences: | 5131 | ||
| Seq/Len: | 19.58 |
| EX3
Paralog alert: 0.61 [within 20: 0.02] - ratio of genomes with paralogs Cluster includes: EX3 YAFD YBHP |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 2_K | 265_T | 5.476 | 1.00 | |
| 31_G | 149_M | 4.08 | 1.00 | |
| 67_L | 94_A | 3.708 | 1.00 | |
| 245_G | 263_W | 2.907 | 1.00 | |
| 242_V | 267_R | 2.671 | 1.00 | |
| 4_V | 263_W | 2.642 | 1.00 | |
| 231_L | 264_A | 2.579 | 1.00 | |
| 32_L | 35_T | 2.523 | 1.00 | |
| 218_K | 221_D | 2.476 | 1.00 | |
| 247_D | 263_W | 2.455 | 1.00 | |
| 198_T | 233_A | 2.391 | 1.00 | |
| 145_P | 236_P | 2.336 | 1.00 | |
| 243_E | 265_T | 2.301 | 1.00 | |
| 75_A | 95_E | 2.285 | 1.00 | |
| 31_G | 105_V | 2.262 | 1.00 | |
| 5_S | 33_Q | 2.249 | 1.00 | |
| 130_Q | 186_W | 2.205 | 1.00 | |
| 74_I | 97_P | 2.157 | 1.00 | |
| 31_G | 107_N | 2.136 | 1.00 | |
| 5_S | 262_V | 2.127 | 1.00 | |
| 197_D | 227_R | 2.091 | 1.00 | |
| 28_D | 70_K | 2.073 | 1.00 | |
| 53_N | 72_T | 2.049 | 1.00 | |
| 95_E | 104_T | 2.046 | 1.00 | |
| 67_L | 107_N | 2.028 | 1.00 | |
| 146_V | 195_L | 1.959 | 1.00 | |
| 181_P | 185_E | 1.808 | 1.00 | |
| 174_T | 181_P | 1.793 | 1.00 | |
| 33_Q | 107_N | 1.776 | 1.00 | |
| 149_M | 231_L | 1.769 | 1.00 | |
| 69_T | 72_T | 1.763 | 1.00 | |
| 97_P | 102_N | 1.76 | 1.00 | |
| 196_V | 201_H | 1.727 | 1.00 | |
| 4_V | 27_P | 1.722 | 1.00 | |
| 191_M | 232_L | 1.716 | 1.00 | |
| 167_N | 170_R | 1.713 | 1.00 | |
| 233_A | 266_F | 1.678 | 1.00 | |
| 29_V | 105_V | 1.649 | 1.00 | |
| 21_I | 25_H | 1.648 | 1.00 | |
| 73_P | 96_I | 1.638 | 1.00 | |
| 27_P | 30_I | 1.627 | 1.00 | |
| 20_A | 24_K | 1.621 | 1.00 | |
| 95_E | 144_N | 1.592 | 1.00 | |
| 35_T | 66_A | 1.585 | 1.00 | |
| 235_Q | 238_A | 1.575 | 1.00 | |
| 187_M | 232_L | 1.56 | 1.00 | |
| 136_L | 195_L | 1.549 | 1.00 | |
| 198_T | 241_C | 1.547 | 1.00 | |
| 53_N | 69_T | 1.531 | 1.00 | |
| 127_Q | 130_Q | 1.511 | 1.00 | |
| 199_F | 209_R | 1.502 | 1.00 | |
| 135_Y | 139_E | 1.501 | 1.00 | |
| 26_Q | 70_K | 1.473 | 1.00 | |
| 201_H | 238_A | 1.466 | 1.00 | |
| 20_A | 23_E | 1.446 | 1.00 | |
| 242_V | 265_T | 1.436 | 1.00 | |
| 133_Q | 137_E | 1.421 | 1.00 | |
| 11_L | 37_V | 1.407 | 0.99 | |
| 202_A | 241_C | 1.405 | 0.99 | |
| 110_F | 128_F | 1.39 | 0.99 | |
| 233_A | 241_C | 1.388 | 0.99 | |
| 3_F | 147_L | 1.385 | 0.99 | |
| 133_Q | 189_R | 1.379 | 0.99 | |
| 69_T | 73_P | 1.374 | 0.99 | |
| 116_R | 180_L | 1.371 | 0.99 | |
| 187_M | 230_L | 1.36 | 0.99 | |
| 146_V | 234_S | 1.353 | 0.99 | |
| 110_F | 129_Y | 1.341 | 0.99 | |
| 2_K | 263_W | 1.335 | 0.99 | |
| 241_C | 264_A | 1.331 | 0.99 | |
| 196_V | 238_A | 1.317 | 0.99 | |
| 130_Q | 134_N | 1.309 | 0.99 | |
| 4_V | 25_H | 1.302 | 0.99 | |
| 231_L | 266_F | 1.293 | 0.99 | |
| 31_G | 67_L | 1.291 | 0.99 | |
| 156_P | 188_D | 1.285 | 0.99 | |
| 234_S | 237_L | 1.28 | 0.99 | |
| 69_T | 94_A | 1.278 | 0.99 | |
| 108_G | 152_M | 1.274 | 0.99 | |
| 240_C | 267_R | 1.272 | 0.99 | |
| 185_E | 189_R | 1.265 | 0.99 | |
| 93_M | 104_T | 1.256 | 0.99 | |
| 127_Q | 131_N | 1.239 | 0.98 | |
| 104_T | 144_N | 1.233 | 0.98 | |
| 166_E | 224_R | 1.225 | 0.98 | |
| 17_Q | 20_A | 1.223 | 0.98 | |
| 196_V | 235_Q | 1.203 | 0.98 | |
| 117_D | 123_P | 1.196 | 0.98 | |
| 84_D | 127_Q | 1.195 | 0.98 | |
| 53_N | 71_E | 1.193 | 0.98 | |
| 148_I | 232_L | 1.19 | 0.98 | |
| 25_H | 247_D | 1.179 | 0.98 | |
| 6_F | 18_L | 1.175 | 0.98 | |
| 30_I | 68_L | 1.17 | 0.97 | |
| 218_K | 222_D | 1.147 | 0.97 | |
| 108_G | 132_L | 1.143 | 0.97 | |
| 4_V | 30_I | 1.137 | 0.97 | |
| 16_H | 20_A | 1.137 | 0.97 | |
| 69_T | 96_I | 1.129 | 0.97 | |
| 45_E | 48_A | 1.127 | 0.97 | |
| 106_I | 136_L | 1.125 | 0.97 | |
| 148_I | 152_M | 1.122 | 0.97 | |
| 29_V | 96_I | 1.119 | 0.96 | |
| 102_N | 240_C | 1.117 | 0.96 | |
| 35_T | 39_D | 1.111 | 0.96 | |
| 98_S | 101_G | 1.094 | 0.96 | |
| 141_K | 236_P | 1.084 | 0.96 | |
| 188_D | 191_M | 1.078 | 0.95 | |
| 233_A | 238_A | 1.078 | 0.95 | |
| 24_K | 249_E | 1.077 | 0.95 | |
| 180_L | 183_E | 1.076 | 0.95 | |
| 108_G | 148_I | 1.073 | 0.95 | |
| 198_T | 244_T | 1.067 | 0.95 | |
| 244_T | 264_A | 1.066 | 0.95 | |
| 95_E | 102_N | 1.066 | 0.95 | |
| 73_P | 76_V | 1.052 | 0.95 | |
| 44_L | 48_A | 1.05 | 0.94 | |
| 137_E | 141_K | 1.046 | 0.94 | |
| 130_Q | 189_R | 1.045 | 0.94 | |
| 57_H | 78_R | 1.04 | 0.94 | |
| 104_T | 146_V | 1.038 | 0.94 | |
| 199_F | 244_T | 1.033 | 0.94 | |
| 158_D | 179_F | 1.013 | 0.93 | |
| 169_K | 174_T | 1.011 | 0.93 | |
| 32_L | 66_A | 1.009 | 0.93 | |
| 131_N | 134_N | 1.004 | 0.93 | |
| 209_R | 248_Y | 1.002 | 0.92 | |
| 22_V | 27_P | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1akoA | 1 | 1 | 100 | 0.192 | Contact Map | 0.803 |
| 4jg3A | 1 | 0.9366 | 100 | 0.224 | Contact Map | 0.809 |
| 2jc4A | 1 | 0.9552 | 100 | 0.227 | Contact Map | 0.787 |
| 2voaA | 2 | 0.9515 | 100 | 0.231 | Contact Map | 0.86 |
| 2j63A | 2 | 0.9664 | 100 | 0.236 | Contact Map | 0.807 |
| 2jc5A | 1 | 0.9366 | 100 | 0.249 | Contact Map | 0.841 |
| 2o3hA | 1 | 0.9366 | 100 | 0.251 | Contact Map | 0.846 |
| 3g91A | 1 | 0.9366 | 100 | 0.253 | Contact Map | 0.865 |
| 4f1rA | 1 | 0.9366 | 100 | 0.28 | Contact Map | 0.812 |
| 1hd7A | 1 | 0.9366 | 100 | 0.283 | Contact Map | 0.842 |
Sequence Conservation (Image Generated using WebLogo v3)