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OPENSEQ.org
SYL - Leucine--tRNA ligase
UniProt: P07813 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10532
Length: 860 (847)
Sequences: 3546
Seq/Len: 4.19
SYL
Paralog alert: 0.76 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: SYI SYL SYV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_L 20_E 5.623 1.00
19_D 113_K 5.433 1.00
142_E 145_K 5.337 1.00
22_R 25_E 5.069 1.00
66_Q 71_K 4.886 1.00
821_T 824_Q 4.607 1.00
387_F 402_K 4.491 1.00
390_L 398_A 4.281 1.00
200_D 204_N 3.771 1.00
822_E 826_R 3.62 1.00
106_A 109_K 3.57 1.00
17_H 21_K 3.537 1.00
69_L 713_T 3.312 1.00
391_D 394_A 3.308 1.00
386_E 402_K 3.305 1.00
845_R 860_G 3.272 1.00
237_N 317_E 3.26 1.00
402_K 406_M 3.157 1.00
316_E 357_K 3.081 1.00
231_E 244_T 3.049 1.00
401_D 405_A 2.977 1.00
437_L 478_V 2.925 1.00
15_Q 767_H 2.904 1.00
755_L 759_R 2.895 1.00
713_T 787_W 2.866 1.00
710_A 714_D 2.844 1.00
716_I 764_F 2.808 1.00
6_R 9_E 2.77 1.00
439_D 481_M 2.694 1.00
437_L 440_G 2.684 1.00
256_C 318_I 2.675 1.00
755_L 778_G 2.67 1.00
308_K 317_E 2.65 1.00
266_P 301_K 2.637 1.00
233_T 244_T 2.582 1.00
200_D 226_R 2.543 1.00
761_L 769_C 2.526 1.00
398_A 401_D 2.516 1.00
799_S 815_T 2.505 1.00
505_C 508_Y 2.451 1.00
812_A 832_E 2.402 1.00
709_I 760_M 2.392 1.00
33_E 71_K 2.386 1.00
710_A 792_E 2.38 1.00
175_C 182_K 2.336 1.00
711_K 728_A 2.314 1.00
618_S 624_K 2.313 1.00
266_P 328_M 2.292 1.00
822_E 851_P 2.272 1.00
304_D 308_K 2.27 1.00
176_C 179_C 2.233 1.00
204_N 226_R 2.227 1.00
710_A 790_A 2.209 1.00
515_S 519_N 2.201 1.00
68_M 759_R 2.2 1.00
758_V 782_I 2.182 1.00
827_E 831_Q 2.175 1.00
438_E 484_L 2.169 1.00
402_K 405_A 2.119 1.00
159_C 162_D 2.116 1.00
207_D 221_R 2.114 1.00
208_K 557_D 2.099 1.00
440_G 478_V 2.096 1.00
107_Y 110_N 2.07 1.00
81_A 128_C 2.05 1.00
709_I 756_A 2.035 1.00
714_D 719_R 2.012 1.00
823_E 826_R 2 1.00
826_R 847_V 1.989 1.00
705_V 756_A 1.964 1.00
825_V 849_Y 1.961 1.00
161_N 181_T 1.947 1.00
341_H 359_V 1.942 1.00
159_C 179_C 1.938 1.00
65_Y 718_R 1.924 1.00
22_R 122_S 1.919 1.00
816_V 825_V 1.915 1.00
849_Y 855_L 1.902 1.00
17_H 774_Q 1.898 1.00
385_G 388_N 1.894 1.00
235_N 242_T 1.891 1.00
232_I 253_F 1.886 1.00
79_W 109_K 1.881 1.00
25_E 122_S 1.877 1.00
819_D 824_Q 1.868 1.00
636_R 660_E 1.844 1.00
759_R 785_A 1.842 1.00
632_V 636_R 1.838 1.00
243_L 261_V 1.826 1.00
311_H 314_T 1.823 1.00
702_R 752_E 1.816 1.00
260_A 323_A 1.815 1.00
824_Q 827_E 1.811 1.00
79_W 124_E 1.803 1.00
233_T 242_T 1.802 1.00
198_Y 550_D 1.8 1.00
350_S 356_I 1.799 1.00
445_T 449_Q 1.799 1.00
325_F 348_F 1.797 1.00
159_C 176_C 1.797 1.00
310_V 317_E 1.784 1.00
358_P 382_F 1.771 0.99
632_V 635_E 1.77 0.99
349_A 354_L 1.768 0.99
205_D 546_K 1.757 0.99
153_T 187_E 1.756 0.99
701_L 736_L 1.747 0.99
801_L 815_T 1.743 0.99
708_T 728_A 1.74 0.99
390_L 395_A 1.738 0.99
633_M 642_V 1.725 0.99
114_M 635_E 1.72 0.99
343_Q 347_E 1.719 0.99
72_N 520_Y 1.714 0.99
346_Y 350_S 1.703 0.99
65_Y 69_L 1.7 0.99
803_V 854_L 1.698 0.99
109_K 124_E 1.69 0.99
801_L 813_K 1.684 0.99
259_L 309_A 1.684 0.99
144_Y 434_M 1.684 0.99
99_P 103_D 1.683 0.99
260_A 337_A 1.677 0.99
259_L 334_A 1.673 0.99
243_L 334_A 1.663 0.99
670_L 765_T 1.661 0.99
271_A 307_F 1.661 0.99
826_R 830_G 1.649 0.99
834_L 837_K 1.645 0.99
705_V 753_A 1.642 0.99
839_L 844_V 1.642 0.99
545_H 556_S 1.637 0.99
109_K 113_K 1.633 0.99
580_N 618_S 1.625 0.99
511_G 514_D 1.612 0.99
154_S 192_F 1.608 0.99
13_K 771_T 1.608 0.99
404_T 410_E 1.607 0.99
256_C 335_V 1.605 0.99
446_P 449_Q 1.604 0.99
525_D 561_K 1.584 0.99
812_A 834_L 1.581 0.99
810_V 813_K 1.574 0.99
159_C 181_T 1.569 0.98
477_T 482_P 1.566 0.98
793_K 796_V 1.56 0.98
514_D 517_A 1.559 0.98
66_Q 718_R 1.559 0.98
830_G 857_L 1.556 0.98
66_Q 69_L 1.552 0.98
508_Y 511_G 1.552 0.98
403_L 408_V 1.552 0.98
141_T 444_P 1.543 0.98
392_H 396_F 1.54 0.98
64_R 766_P 1.534 0.98
309_A 320_V 1.534 0.98
138_K 142_E 1.532 0.98
387_F 399_I 1.531 0.98
243_L 259_L 1.526 0.98
65_Y 713_T 1.524 0.98
265_H 328_M 1.52 0.98
59_G 528_I 1.519 0.98
762_N 783_D 1.517 0.98
69_L 789_V 1.516 0.98
161_N 179_C 1.511 0.98
422_V 490_F 1.508 0.98
758_V 769_C 1.505 0.98
176_C 181_T 1.5 0.98
313_L 402_K 1.489 0.98
843_T 860_G 1.489 0.98
707_K 797_E 1.488 0.98
200_D 415_Y 1.488 0.98
344_R 347_E 1.486 0.98
819_D 852_G 1.483 0.98
845_R 859_V 1.483 0.98
231_E 410_E 1.483 0.98
230_V 400_A 1.479 0.98
401_D 404_T 1.474 0.97
258_Y 321_W 1.466 0.97
321_W 348_F 1.461 0.97
361_L 364_D 1.459 0.97
226_R 413_V 1.456 0.97
35_Y 720_Q 1.455 0.97
830_G 847_V 1.451 0.97
193_I 494_M 1.449 0.97
279_A 283_D 1.449 0.97
277_E 280_A 1.449 0.97
142_E 447_D 1.445 0.97
475_K 484_L 1.443 0.97
437_L 483_A 1.437 0.97
504_T 522_L 1.435 0.97
278_L 303_V 1.425 0.97
835_V 838_Y 1.424 0.97
434_M 442_V 1.422 0.97
26_V 780_G 1.421 0.97
323_A 348_F 1.42 0.97
811_R 838_Y 1.42 0.97
253_F 403_L 1.415 0.97
547_L 551_A 1.407 0.96
28_E 72_N 1.407 0.96
397_N 401_D 1.398 0.96
842_V 859_V 1.397 0.96
513_L 518_A 1.395 0.96
511_G 515_S 1.385 0.96
756_A 760_M 1.384 0.96
725_A 764_F 1.38 0.96
704_D 735_K 1.377 0.96
232_I 403_L 1.374 0.96
519_N 555_N 1.374 0.96
275_N 279_A 1.369 0.96
670_L 768_I 1.368 0.96
284_E 301_K 1.366 0.96
151_K 436_T 1.361 0.95
435_V 476_T 1.359 0.95
549_R 557_D 1.358 0.95
243_L 320_V 1.351 0.95
758_V 772_L 1.348 0.95
709_I 790_A 1.345 0.95
201_E 549_R 1.341 0.95
161_N 176_C 1.34 0.95
26_V 29_D 1.34 0.95
837_K 840_D 1.339 0.95
14_V 771_T 1.339 0.95
89_A 92_K 1.337 0.95
847_V 857_L 1.329 0.95
159_C 166_L 1.328 0.95
257_T 357_K 1.326 0.94
704_D 708_T 1.326 0.94
690_N 693_A 1.323 0.94
254_M 386_E 1.322 0.94
761_L 765_T 1.322 0.94
398_A 402_K 1.321 0.94
702_R 794_A 1.318 0.94
135_W 138_K 1.309 0.94
706_H 709_I 1.308 0.94
834_L 838_Y 1.308 0.94
387_F 398_A 1.306 0.94
803_V 813_K 1.294 0.94
41_L 132_Y 1.293 0.93
136_E 430_A 1.293 0.93
434_M 444_P 1.293 0.93
156_V 165_V 1.289 0.93
313_L 403_L 1.288 0.93
16_L 19_D 1.288 0.93
471_P 475_K 1.288 0.93
705_V 709_I 1.279 0.93
716_I 725_A 1.278 0.93
822_E 849_Y 1.27 0.93
802_V 825_V 1.265 0.92
393_E 396_F 1.259 0.92
259_L 318_I 1.256 0.92
831_Q 836_A 1.255 0.92
215_T 531_I 1.255 0.92
241_N 270_K 1.253 0.92
125_L 503_Y 1.247 0.92
824_Q 828_R 1.247 0.92
12_S 16_L 1.245 0.92
492_T 495_E 1.244 0.92
250_P 400_A 1.244 0.92
438_E 481_M 1.241 0.92
820_A 825_V 1.24 0.91
68_M 786_P 1.236 0.91
708_T 760_M 1.236 0.91
280_A 284_E 1.236 0.91
430_A 495_E 1.235 0.91
438_E 482_P 1.232 0.91
103_D 106_A 1.232 0.91
839_L 842_V 1.232 0.91
262_A 265_H 1.231 0.91
762_N 769_C 1.23 0.91
245_V 259_L 1.227 0.91
283_D 287_N 1.226 0.91
820_A 824_Q 1.225 0.91
820_A 852_G 1.224 0.91
541_F 560_A 1.224 0.91
713_T 718_R 1.222 0.91
676_L 733_M 1.222 0.91
216_V 565_C 1.221 0.91
61_V 647_M 1.218 0.91
261_V 268_A 1.217 0.90
235_N 408_V 1.215 0.90
675_K 679_E 1.215 0.90
63_A 73_V 1.215 0.90
343_Q 346_Y 1.215 0.90
105_I 126_A 1.205 0.90
712_V 725_A 1.205 0.90
343_Q 374_A 1.203 0.90
437_L 441_T 1.199 0.90
9_E 13_K 1.197 0.89
28_E 517_A 1.196 0.89
53_V 115_L 1.194 0.89
205_D 208_K 1.193 0.89
136_E 490_F 1.191 0.89
390_L 394_A 1.191 0.89
807_N 859_V 1.19 0.89
9_E 12_S 1.186 0.89
756_A 759_R 1.182 0.89
116_G 767_H 1.181 0.89
306_G 322_A 1.177 0.88
276_P 280_A 1.177 0.88
153_T 189_P 1.174 0.88
145_K 447_D 1.172 0.88
453_I 456_E 1.166 0.88
510_E 514_D 1.164 0.88
796_V 818_V 1.163 0.88
361_L 380_V 1.158 0.87
839_L 857_L 1.154 0.87
826_R 849_Y 1.153 0.87
369_D 372_Q 1.15 0.87
269_Q 282_I 1.143 0.86
708_T 732_L 1.141 0.86
24_F 783_D 1.14 0.86
500_Y 545_H 1.139 0.86
751_Q 755_L 1.136 0.86
478_V 483_A 1.135 0.86
770_F 781_D 1.135 0.86
712_V 729_I 1.129 0.85
839_L 859_V 1.128 0.85
151_K 189_P 1.128 0.85
631_Q 635_E 1.125 0.85
708_T 712_V 1.121 0.85
228_E 411_R 1.12 0.85
141_T 145_K 1.119 0.85
814_I 828_R 1.118 0.85
261_V 334_A 1.114 0.84
102_Y 106_A 1.109 0.84
234_F 256_C 1.107 0.84
733_M 757_V 1.104 0.84
729_I 761_L 1.102 0.84
179_C 182_K 1.102 0.84
257_T 354_L 1.1 0.83
674_W 772_L 1.099 0.83
828_R 831_Q 1.098 0.83
572_D 580_N 1.095 0.83
201_E 205_D 1.093 0.83
790_A 795_M 1.092 0.83
126_A 129_T 1.092 0.83
47_R 107_Y 1.092 0.83
826_R 843_T 1.091 0.83
825_V 854_L 1.09 0.83
844_V 847_V 1.085 0.82
712_V 760_M 1.085 0.82
281_F 285_C 1.085 0.82
325_F 337_A 1.083 0.82
674_W 768_I 1.083 0.82
806_V 838_Y 1.081 0.82
818_V 852_G 1.081 0.82
120_D 123_R 1.078 0.82
830_G 836_A 1.077 0.82
512_M 553_M 1.077 0.82
228_E 413_V 1.074 0.81
69_L 718_R 1.074 0.81
54_R 656_L 1.073 0.81
160_P 184_E 1.071 0.81
474_A 484_L 1.071 0.81
803_V 810_V 1.07 0.81
260_A 348_F 1.07 0.81
250_P 396_F 1.067 0.81
833_H 836_A 1.066 0.81
262_A 324_N 1.063 0.80
67_R 118_G 1.062 0.80
404_T 411_R 1.061 0.80
780_G 785_A 1.06 0.80
814_I 832_E 1.06 0.80
820_A 828_R 1.06 0.80
39_S 75_Q 1.058 0.80
830_G 844_V 1.057 0.80
569_V 656_L 1.054 0.80
346_Y 370_L 1.051 0.79
667_N 671_K 1.051 0.79
786_P 789_V 1.049 0.79
232_I 245_V 1.049 0.79
110_N 114_M 1.049 0.79
281_F 301_K 1.049 0.79
636_R 664_E 1.048 0.79
254_M 402_K 1.047 0.79
816_V 820_A 1.047 0.79
75_Q 119_Y 1.047 0.79
69_L 787_W 1.044 0.79
806_V 835_V 1.04 0.78
23_T 781_D 1.038 0.78
475_K 482_P 1.036 0.78
172_I 177_W 1.036 0.78
284_E 287_N 1.031 0.77
33_E 66_Q 1.029 0.77
162_D 176_C 1.028 0.77
762_N 782_I 1.027 0.77
823_E 827_E 1.027 0.77
326_V 335_V 1.025 0.77
704_D 707_K 1.024 0.77
573_A 577_V 1.022 0.77
39_S 59_G 1.017 0.76
673_V 757_V 1.012 0.76
479_N 483_A 1.011 0.76
709_I 788_P 1.01 0.75
437_L 443_M 1.006 0.75
136_E 495_E 1.006 0.75
162_D 179_C 1.005 0.75
715_D 724_T 1.004 0.75
237_N 310_V 1.004 0.75
812_A 820_A 1.003 0.75
701_L 753_A 1.002 0.75
305_T 322_A 1.001 0.75
159_C 437_L 1 0.74
844_V 857_L 1 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4arcA10.99881000.111Contact Map0.772
2v0cA10.9861000.147Contact Map0.769
3ziuA20.71631000.384Contact Map0.71
1ffyA10.8431000.396Contact Map0.591
1gaxA20.79651000.42Contact Map0.691
1ileA10.79771000.433Contact Map0.663
1wz2A20.86051000.452Contact Map0.724
1wkbA10.7641000.486Contact Map0.742
1rqgA10.61281000.674Contact Map0.72
2x1lA30.57441000.682Contact Map0.696
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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