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OPENSEQ.org
ILVA - L-threonine dehydratase biosynthetic IlvA
UniProt: P04968 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10493
Length: 514 (499)
Sequences: 1143
Seq/Len: 2.29
ILVA
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
183_V 200_I 5.267 1.00
193_A 259_L 4.631 1.00
141_K 144_E 4.608 1.00
221_K 225_D 3.765 1.00
74_T 77_Q 3.543 1.00
231_D 246_R 3.416 1.00
144_E 148_Q 3.304 1.00
197_A 258_Y 3.123 1.00
158_D 249_D 3.082 1.00
47_V 309_R 3.061 1.00
220_L 247_I 2.787 1.00
106_L 127_E 2.734 1.00
72_G 161_M 2.734 1.00
215_E 266_D 2.696 1.00
250_E 253_R 2.621 1.00
69_M 159_H 2.593 1.00
24_P 68_A 2.571 1.00
98_S 105_A 2.523 1.00
214_A 242_V 2.399 1.00
186_P 315_S 2.39 1.00
173_L 311_A 2.371 1.00
218_A 264_T 2.366 1.00
436_Y 501_D 2.329 1.00
219_C 223_A 2.291 1.00
31_V 176_Q 2.283 1.00
226_A 230_V 2.262 1.00
185_V 196_V 2.25 1.00
31_V 175_Q 2.217 1.00
242_V 288_S 2.192 1.00
201_K 260_D 2.184 1.00
218_A 222_A 2.179 1.00
224_L 262_I 2.169 1.00
75_E 79_A 2.142 1.00
48_I 296_M 2.14 1.00
187_V 220_L 2.14 1.00
75_E 78_K 2.112 1.00
193_A 255_C 2.091 1.00
246_R 249_D 2.053 0.99
220_L 255_C 2.051 0.99
196_V 313_I 2.019 0.99
104_K 127_E 1.974 0.99
204_M 207_I 1.948 0.99
208_K 261_D 1.943 0.99
285_A 314_L 1.94 0.99
99_A 105_A 1.921 0.99
163_I 254_L 1.903 0.99
220_L 262_I 1.896 0.99
106_L 151_F 1.88 0.99
274_M 288_S 1.874 0.99
85_A 135_F 1.874 0.99
255_C 259_L 1.858 0.99
223_A 229_P 1.849 0.99
28_A 67_Y 1.832 0.98
171_L 199_L 1.829 0.98
239_A 288_S 1.819 0.98
36_K 47_V 1.812 0.98
242_V 291_L 1.747 0.98
33_P 55_R 1.707 0.97
135_F 139_K 1.698 0.97
187_V 262_I 1.664 0.97
19_A 161_M 1.641 0.96
266_D 269_A 1.626 0.96
432_Q 483_D 1.607 0.96
177_D 180_L 1.597 0.95
40_L 293_L 1.597 0.95
211_A 220_L 1.592 0.95
269_A 298_K 1.588 0.95
108_V 145_L 1.582 0.95
78_K 103_V 1.58 0.95
254_L 258_Y 1.555 0.94
70_M 103_V 1.546 0.94
397_Q 401_D 1.532 0.94
160_P 250_E 1.527 0.94
502_E 505_N 1.49 0.93
180_L 311_A 1.485 0.92
145_L 149_Q 1.476 0.92
181_D 308_E 1.475 0.92
210_I 261_D 1.469 0.92
223_A 247_I 1.467 0.92
187_V 193_A 1.463 0.92
157_F 314_L 1.463 0.92
109_M 130_L 1.457 0.91
277_L 285_A 1.423 0.90
136_D 217_S 1.42 0.90
25_V 28_A 1.419 0.90
222_A 230_V 1.419 0.90
393_K 397_Q 1.417 0.90
221_K 264_T 1.401 0.89
169_L 192_L 1.4 0.89
104_K 151_F 1.399 0.89
239_A 270_I 1.398 0.89
48_I 300_I 1.396 0.89
292_A 312_H 1.395 0.89
348_E 354_K 1.385 0.88
77_Q 80_H 1.382 0.88
69_M 154_V 1.379 0.88
180_L 207_I 1.372 0.88
139_K 143_I 1.371 0.88
80_H 150_G 1.37 0.88
213_E 247_I 1.368 0.88
23_A 26_Y 1.364 0.87
155_P 159_H 1.356 0.87
111_T 133_A 1.352 0.87
196_V 200_I 1.345 0.86
49_L 309_R 1.345 0.86
183_V 196_V 1.336 0.86
213_E 217_S 1.334 0.86
272_A 331_C 1.325 0.85
457_Y 487_D 1.323 0.85
216_D 236_G 1.318 0.85
182_R 208_K 1.317 0.85
186_P 194_A 1.312 0.85
227_G 256_Q 1.307 0.84
274_M 319_V 1.306 0.84
170_A 196_V 1.301 0.84
449_R 453_T 1.295 0.84
141_K 145_L 1.292 0.83
36_K 49_L 1.285 0.83
77_Q 152_T 1.284 0.83
60_S 163_I 1.271 0.82
163_I 251_T 1.265 0.82
219_C 247_I 1.264 0.81
222_A 225_D 1.264 0.81
159_H 162_V 1.262 0.81
437_S 502_E 1.261 0.81
45_D 306_R 1.252 0.81
216_D 235_V 1.252 0.81
182_R 308_E 1.252 0.81
434_R 501_D 1.238 0.80
493_N 499_C 1.236 0.79
200_I 209_V 1.231 0.79
396_L 400_N 1.231 0.79
145_L 151_F 1.225 0.79
215_E 264_T 1.22 0.78
109_M 121_V 1.215 0.78
134_N 137_E 1.212 0.78
459_N 480_E 1.207 0.77
76_E 80_H 1.203 0.77
355_F 381_V 1.202 0.77
73_L 77_Q 1.201 0.77
46_N 310_L 1.194 0.76
83_I 151_F 1.189 0.76
112_A 133_A 1.175 0.74
222_A 226_A 1.172 0.74
187_V 211_A 1.17 0.74
67_Y 100_R 1.167 0.74
143_I 146_S 1.165 0.74
219_C 222_A 1.165 0.74
182_R 210_I 1.163 0.73
69_M 155_P 1.154 0.73
201_K 209_V 1.153 0.72
198_V 254_L 1.152 0.72
34_L 177_D 1.15 0.72
104_K 149_Q 1.144 0.72
229_P 246_R 1.143 0.71
113_T 116_I 1.138 0.71
94_V 107_I 1.138 0.71
341_L 396_L 1.137 0.71
185_V 209_V 1.137 0.71
218_A 221_K 1.135 0.71
157_F 246_R 1.134 0.71
142_A 153_W 1.13 0.70
213_E 224_L 1.129 0.70
194_A 254_L 1.128 0.70
70_M 94_V 1.127 0.70
358_L 402_G 1.126 0.70
24_P 71_A 1.124 0.70
139_K 155_P 1.118 0.69
15_E 471_D 1.118 0.69
400_N 405_S 1.104 0.68
209_V 259_L 1.102 0.67
324_L 341_L 1.1 0.67
476_L 488_F 1.1 0.67
278_F 284_V 1.092 0.66
253_R 256_Q 1.092 0.66
481_L 488_F 1.09 0.66
185_V 193_A 1.089 0.66
437_S 500_H 1.08 0.65
84_T 107_I 1.08 0.65
247_I 255_C 1.074 0.65
193_A 209_V 1.074 0.65
84_T 153_W 1.07 0.64
486_P 489_E 1.069 0.64
214_A 217_S 1.068 0.64
193_A 211_A 1.066 0.64
239_A 242_V 1.065 0.64
467_S 470_T 1.063 0.63
173_L 180_L 1.057 0.63
296_M 300_I 1.057 0.63
164_A 167_G 1.055 0.63
170_A 200_I 1.051 0.62
271_C 291_L 1.05 0.62
454_L 491_R 1.046 0.62
83_I 141_K 1.04 0.61
120_A 280_D 1.039 0.61
74_T 78_K 1.037 0.61
187_V 224_L 1.036 0.60
217_S 232_L 1.032 0.60
70_M 101_L 1.03 0.60
184_F 296_M 1.03 0.60
44_L 48_I 1.029 0.60
113_T 156_P 1.022 0.59
127_E 149_Q 1.019 0.59
34_L 311_A 1.016 0.58
221_K 262_I 1.015 0.58
20_V 199_L 1.011 0.58
108_V 131_H 1.009 0.57
490_T 494_E 1.005 0.57
252_F 256_Q 1.004 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tdjA111000.256Contact Map0.653
3iauA20.65561000.66Contact Map0.79
2gn0A40.64011000.664Contact Map0.826
1v71A10.62451000.669Contact Map0.736
3ss7X10.64591000.675Contact Map0.568
1ve5A40.59141000.68Contact Map0.75
4d9iA20.65561000.682Contact Map0.692
3l6bA10.65761000.682Contact Map0.752
4h27A10.64791000.685Contact Map0.661
2rkbA50.59921000.688Contact Map0.659
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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