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OPENSEQ.org
DPO3E - DNA polymerase III subunit epsilon
UniProt: P03007 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10243
Length: 243 (232)
Sequences: 609
Seq/Len: 2.62
DPO3E
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
138_F 152_Y 5.005 1.00
63_F 69_A 4.071 1.00
55_D 78_T 3.504 1.00
86_F 90_I 3.472 1.00
11_L 97_I 3.434 1.00
57_L 70_D 3.226 1.00
230_D 242_R 2.976 1.00
47_N 89_Y 2.83 1.00
84_D 88_D 2.772 1.00
109_Y 113_L 2.748 1.00
31_I 58_V 2.492 1.00
31_I 68_I 2.467 1.00
72_F 76_K 2.39 1.00
46_N 89_Y 2.193 1.00
101_A 132_A 2.179 1.00
87_M 111_F 2.168 1.00
28_H 59_D 2.009 0.99
131_L 143_N 1.991 0.99
48_F 86_F 1.977 0.99
53_K 75_D 1.973 0.99
84_D 118_I 1.968 0.99
52_L 82_V 1.912 0.99
141_K 150_A 1.849 0.99
78_T 81_E 1.814 0.99
68_I 72_F 1.763 0.98
19_N 26_E 1.761 0.98
60_P 64_G 1.758 0.98
33_I 86_F 1.755 0.98
86_F 111_F 1.701 0.98
226_E 242_R 1.692 0.98
8_Q 94_E 1.688 0.98
107_M 121_T 1.685 0.98
58_V 73_L 1.675 0.98
68_I 74_L 1.668 0.97
144_S 147_A 1.589 0.96
58_V 68_I 1.575 0.96
58_V 70_D 1.555 0.96
82_V 86_F 1.544 0.95
58_V 63_F 1.538 0.95
38_V 43_L 1.516 0.95
34_G 168_A 1.488 0.94
10_V 38_V 1.462 0.93
214_V 217_A 1.439 0.93
28_H 144_S 1.426 0.92
142_R 150_A 1.391 0.91
224_A 227_A 1.386 0.91
41_R 179_T 1.377 0.90
94_E 128_T 1.357 0.89
52_L 78_T 1.325 0.88
130_S 175_Y 1.306 0.87
55_D 80_A 1.294 0.86
138_F 151_R 1.284 0.86
228_R 232_V 1.27 0.85
104_I 127_V 1.242 0.83
180_G 183_T 1.236 0.83
170_I 180_G 1.232 0.82
223_A 227_A 1.223 0.82
85_E 88_D 1.217 0.81
18_M 105_G 1.217 0.81
212_L 236_G 1.193 0.79
33_I 48_F 1.181 0.79
52_L 111_F 1.172 0.78
34_G 180_G 1.167 0.77
86_F 95_L 1.166 0.77
53_K 78_T 1.135 0.75
155_D 158_K 1.131 0.74
19_N 61_E 1.128 0.74
229_L 232_V 1.123 0.73
51_Y 68_I 1.121 0.73
219_D 223_A 1.121 0.73
50_V 86_F 1.117 0.73
62_A 65_V 1.114 0.73
11_L 140_G 1.105 0.72
154_I 160_T 1.1 0.71
109_Y 112_S 1.086 0.70
28_H 228_R 1.075 0.69
108_D 120_K 1.074 0.69
18_M 59_D 1.073 0.68
154_I 158_K 1.07 0.68
120_K 123_T 1.07 0.68
41_R 182_Q 1.059 0.67
128_T 138_F 1.058 0.67
20_Q 28_H 1.049 0.66
182_Q 185_M 1.042 0.65
137_M 152_Y 1.042 0.65
34_G 70_D 1.04 0.65
202_I 205_I 1.04 0.65
97_I 135_R 1.036 0.65
226_E 230_D 1.026 0.63
52_L 86_F 1.019 0.63
31_I 61_E 1.012 0.62
33_I 52_L 1.009 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2guiA10.77781000.653Contact Map0.669
2xriA10.76541000.701Contact Map0.549
1w0hA10.76541000.701Contact Map0.614
3mxmB20.8231000.702Contact Map0.579
3cg7A20.96711000.702Contact Map0.553
4hxhB20.89711000.704Contact Map0.613
1zbuA40.86011000.705Contact Map0.582
2p1jA20.74071000.707Contact Map0.613
3v9wA40.76541000.708Contact Map0.518
2f96A20.75311000.709Contact Map0.484
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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