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OPENSEQ.org

LSPA - Lipoprotein signal peptidase
UniProt: P00804 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10548
Length: 164 (150)
Sequences: 1963
Seq/Len: 13.09

LSPA
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_S 124_M 4.274 1.00
19_V 143_A 3.506 1.00
52_R 120_F 3.043 1.00
46_L 125_I 2.883 1.00
20_L 113_F 2.868 1.00
19_V 106_G 2.755 1.00
126_D 133_H 2.747 1.00
30_I 34_F 2.617 1.00
24_L 113_F 2.262 1.00
142_T 146_V 2.164 1.00
34_F 40_V 2.132 1.00
51_A 136_T 2.027 1.00
106_G 143_A 1.946 1.00
29_L 33_N 1.925 1.00
145_C 149_A 1.895 1.00
58_F 135_A 1.892 1.00
31_L 122_V 1.829 1.00
134_F 145_C 1.828 1.00
47_N 126_D 1.821 1.00
26_S 139_L 1.809 1.00
139_L 142_T 1.806 1.00
31_L 52_R 1.793 1.00
23_D 27_K 1.766 1.00
83_L 105_I 1.704 1.00
104_I 147_G 1.665 1.00
102_A 106_G 1.652 1.00
22_I 139_L 1.613 1.00
139_L 143_A 1.56 1.00
30_I 50_Y 1.455 1.00
148_A 152_V 1.429 1.00
34_F 50_Y 1.427 1.00
54_Y 59_S 1.357 0.99
28_Y 32_Q 1.352 0.99
81_V 85_V 1.35 0.99
47_N 128_Y 1.347 0.99
153_L 157_L 1.327 0.99
42_L 48_L 1.309 0.99
20_L 109_L 1.306 0.99
78_G 82_I 1.301 0.99
85_V 89_R 1.274 0.99
30_I 48_L 1.273 0.99
46_L 127_F 1.267 0.99
25_G 29_L 1.257 0.99
16_V 102_A 1.251 0.99
125_I 142_T 1.251 0.99
54_Y 120_F 1.24 0.98
146_V 150_L 1.238 0.98
100_A 150_L 1.234 0.98
54_Y 62_A 1.231 0.98
50_Y 120_F 1.228 0.98
41_P 44_P 1.225 0.98
39_T 47_N 1.189 0.98
118_H 122_V 1.181 0.98
100_A 154_E 1.16 0.97
95_K 99_I 1.155 0.97
31_L 118_H 1.149 0.97
16_V 105_I 1.136 0.97
49_H 136_T 1.134 0.97
68_Q 72_F 1.125 0.97
124_M 139_L 1.119 0.96
48_L 125_I 1.113 0.96
59_S 62_A 1.094 0.96
15_L 102_A 1.092 0.96
80_S 105_I 1.082 0.96
68_Q 71_F 1.079 0.95
26_S 30_I 1.074 0.95
21_I 25_G 1.067 0.95
39_T 49_H 1.059 0.95
34_F 38_D 1.052 0.95
49_H 126_D 1.045 0.94
96_L 100_A 1.041 0.94
19_V 103_L 1.034 0.94
80_S 108_A 1.032 0.94
76_A 112_L 1.023 0.93
24_L 117_W 1.018 0.93
96_L 150_L 1.016 0.93
82_I 86_M 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
4b19A10.18292.90.956Contact Map0.378
3hzqA10.59762.40.958Contact Map0.076
1zklA10.34762.40.958Contact Map0.356
4ev6A50.49392.20.959Contact Map0.556
4i0uA100.493920.96Contact Map0.519
2kv5A10.19511.70.962Contact Map0.626
4g1uA20.95121.40.963Contact Map0.163
2l6wA20.22561.30.965Contact Map0.34
2l2tA20.25610.90.967Contact Map0.232
1gotG10.17070.90.968Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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