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OPENSEQ.org
LEP - Signal peptidase I
UniProt: P00803 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10530
Length: 324 (320)
Sequences: 511
Seq/Len: 1.60
LEP
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_A 124_G 2.984 1.00
303_S 316_R 2.772 1.00
19_L 64_G 2.737 1.00
10_V 75_L 2.681 1.00
289_P 292_N 2.586 1.00
132_V 271_M 2.448 1.00
87_I 96_L 2.249 0.99
132_V 293_L 2.221 0.99
93_M 97_L 2.198 0.99
148_A 271_M 2.188 0.99
119_T 125_H 1.849 0.97
145_I 297_A 1.681 0.94
13_T 72_A 1.68 0.94
149_V 232_G 1.676 0.94
21_C 25_F 1.675 0.94
23_D 38_A 1.64 0.93
62_E 66_S 1.633 0.92
158_Y 163_K 1.553 0.90
111_I 121_I 1.514 0.88
230_T 233_D 1.51 0.88
83_E 145_I 1.508 0.88
226_E 237_R 1.505 0.88
155_K 263_I 1.443 0.85
92_M 131_I 1.438 0.84
43_G 47_D 1.435 0.84
4_M 7_L 1.419 0.83
78_R 83_E 1.417 0.83
29_P 32_R 1.415 0.83
234_V 238_I 1.413 0.83
90_G 93_M 1.409 0.83
83_E 92_M 1.408 0.82
47_D 50_T 1.386 0.81
26_F 30_K 1.385 0.81
23_D 31_R 1.38 0.81
118_K 291_A 1.369 0.80
25_F 149_V 1.358 0.79
126_P 293_L 1.355 0.79
11_I 139_D 1.354 0.79
73_I 77_V 1.343 0.78
19_L 61_L 1.33 0.77
206_T 211_E 1.323 0.77
28_A 32_R 1.306 0.75
139_D 142_L 1.302 0.75
10_V 116_Y 1.3 0.75
27_F 61_L 1.295 0.75
63_T 67_V 1.285 0.74
243_I 246_D 1.276 0.73
92_M 145_I 1.267 0.72
205_A 208_G 1.256 0.71
39_Q 46_L 1.256 0.71
113_D 120_L 1.25 0.71
41_A 44_D 1.249 0.71
131_I 145_I 1.245 0.70
18_I 30_K 1.24 0.70
206_T 213_P 1.239 0.70
3_N 262_W 1.228 0.69
300_I 319_R 1.226 0.69
208_G 211_E 1.222 0.68
83_E 297_A 1.221 0.68
39_Q 51_L 1.221 0.68
38_A 62_E 1.212 0.67
97_L 316_R 1.202 0.66
13_T 93_M 1.201 0.66
44_D 49_A 1.201 0.66
193_F 239_L 1.201 0.66
40_A 48_K 1.196 0.66
12_A 29_P 1.194 0.66
18_I 22_V 1.181 0.64
132_V 148_A 1.18 0.64
202_G 208_G 1.177 0.64
299_A 323_I 1.172 0.64
18_I 21_C 1.169 0.63
41_A 48_K 1.165 0.63
78_R 297_A 1.165 0.63
98_I 271_M 1.158 0.62
58_P 61_L 1.153 0.62
262_W 312_P 1.137 0.60
37_A 51_L 1.136 0.60
86_Q 304_F 1.133 0.60
119_T 131_I 1.132 0.60
218_K 298_T 1.131 0.60
33_E 291_A 1.131 0.60
101_F 287_F 1.13 0.59
125_H 290_E 1.126 0.59
37_A 284_Y 1.117 0.58
47_D 51_L 1.116 0.58
201_N 209_F 1.115 0.58
11_I 25_F 1.111 0.57
44_D 48_K 1.111 0.57
201_N 212_V 1.109 0.57
4_M 303_S 1.109 0.57
209_F 212_V 1.106 0.57
10_V 24_K 1.105 0.57
12_A 280_A 1.103 0.57
67_V 119_T 1.102 0.57
299_A 322_G 1.097 0.56
57_K 65_A 1.093 0.56
3_N 13_T 1.092 0.55
82_Y 103_L 1.091 0.55
72_A 76_I 1.085 0.55
271_M 294_V 1.079 0.54
41_A 50_T 1.077 0.54
42_A 50_T 1.076 0.54
38_A 268_Q 1.075 0.54
303_S 315_L 1.072 0.53
17_G 163_K 1.069 0.53
202_G 211_E 1.067 0.53
86_Q 143_D 1.066 0.53
78_R 84_P 1.064 0.53
11_I 29_P 1.061 0.52
29_P 226_E 1.06 0.52
113_D 135_K 1.059 0.52
191_S 194_V 1.058 0.52
37_A 44_D 1.057 0.52
207_S 211_E 1.055 0.52
12_A 93_M 1.054 0.52
111_I 120_L 1.053 0.51
43_G 46_L 1.053 0.51
41_A 45_S 1.051 0.51
211_E 214_K 1.046 0.51
17_G 68_F 1.045 0.51
117_Q 298_T 1.045 0.51
13_T 62_E 1.039 0.50
208_G 212_V 1.039 0.50
202_G 206_T 1.033 0.49
8_I 24_K 1.033 0.49
13_T 34_R 1.033 0.49
201_N 208_G 1.031 0.49
13_T 24_K 1.03 0.49
201_N 213_P 1.028 0.49
204_E 207_S 1.028 0.49
27_F 35_Q 1.027 0.49
37_A 50_T 1.026 0.49
135_K 292_N 1.022 0.48
83_E 131_I 1.021 0.48
132_V 142_L 1.021 0.48
144_Y 288_V 1.02 0.48
28_A 31_R 1.02 0.48
271_M 293_L 1.02 0.48
58_P 229_E 1.017 0.48
205_A 210_F 1.015 0.47
149_V 263_I 1.015 0.47
10_V 262_W 1.009 0.47
46_L 50_T 1.007 0.47
256_G 323_I 1.007 0.47
84_P 107_F 1.006 0.46
107_F 278_N 1.005 0.46
62_E 294_V 1.004 0.46
41_A 49_A 1.004 0.46
70_V 74_V 1.003 0.46
49_A 52_K 1.002 0.46
158_Y 277_D 1.001 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b12A40.76541000.459Contact Map0.528
4me8A10.4661000.7Contact Map0.687
4k8wA10.39511000.725Contact Map0.647
1umuA20.354996.30.947Contact Map0.849
2hnfA10.388995.50.95Contact Map0.764
1kcaA80.317995.30.951Contact Map0.844
3k2zA20.515483.90.963Contact Map0.445
1jhfA20.490735.20.974Contact Map0.503
3bdnA20.503129.10.975Contact Map0.644
2kv5A10.101910.40.979Contact Map0.21
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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