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OPENSEQ.org
cI_B_20_cIV_A_20_Pdenitr
Genes: A B A+B
Length: 175 539 674
Sequences: 1183 4201 842
Seq/Len: 6.76 7.79 1.25
MirrorTree (Pazo et al. 2001) 0.12
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.01 0.01 0.00
2 0.01 0.01 0.00
5 0.01 0.02 0.01
10 0.02 0.02 0.02
20 0.02 0.03 0.06
100 0.03 0.04 0.25
∞ 0.08 0.08 1.18
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
67_Y 72_W 1.21 0.59 0.00
30_L 349_G 0.93 0.33 0.00
109_E 533_K 0.90 0.31 0.00
161_L 183_I 0.88 0.29 0.00
109_E 363_G 0.87 0.28 0.00
146_V 101_M 0.86 0.28 0.00
48_M 379_S 0.86 0.27 0.00
32_T 482_F 0.84 0.26 0.00
111_R 395_A 0.84 0.25 0.00
115_S 74_V 0.82 0.24 0.00
69_L 22_F 0.82 0.24 0.00
111_R 36_V 0.81 0.23 0.00
75_A 219_S 0.78 0.21 0.00
114_I 501_R 0.77 0.20 0.00
146_V 72_W 0.76 0.20 0.00
115_S 134_L 0.76 0.20 0.00
161_L 158_T 0.76 0.20 0.00
109_E 132_A 0.75 0.20 0.00
126_Y 274_I 0.75 0.20 0.00
43_G 26_I 0.75 0.19 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3486 1.25 cI_B_20_cIV_A_20_Pdenitr Δgene:(1, ∞) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3484 1.42 cI_B_2_cIV_A_2_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3483 1.4 cI_B_6_cIV_A_6_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
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