May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

THID - THIM
UniProt: P76422 - P76423
Length: 528
Sequences: 407
Seq/Len: 0.79
I_Prob: 0.00

THID - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Paralog alert: 0.62 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PDXK PDXY THID
THIM - Hydroxyethylthiazole kinase
Paralog alert: 0.08 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: THIM
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
217_A 28_M 1.31 0.00
73_I 131_I 1.15 0.00
112_S 254_W 1.13 0.00
81_L 132_M 1.10 0.00
213_C 201_C 1.10 0.00
228_N 25_V 1.10 0.00
192_R 69_I 1.08 0.00
132_Q 249_F 1.05 0.00
30_L 194_T 0.98 0.00
97_Y 254_W 0.97 0.00
20_I 144_V 0.96 0.00
83_E 171_T 0.96 0.00
231_D 116_L 0.95 0.00
146_L 209_A 0.93 0.00
135_L 58_S 0.93 0.00
60_V 134_L 0.93 0.00
64_L 249_F 0.90 0.00
15_S 129_S 0.89 0.00
217_A 202_A 0.89 0.00
123_A 69_I 0.89 0.00
38_I 16_H 0.89 0.00
54_R 246_V 0.88 0.00
153_R 111_H 0.88 0.00
67_V 168_V 0.88 0.00
188_W 177_V 0.87 0.00
167_A 135_A 0.87 0.00
104_L 110_R 0.87 0.00
117_L 56_E 0.87 0.00
8_T 103_V 0.86 0.00
239_W 160_L 0.86 0.00
220_A 67_L 0.86 0.00
242_S 224_A 0.86 0.00
201_P 182_R 0.85 0.00
33_Y 210_C 0.84 0.00
24_L 24_L 0.84 0.00
78_I 232_G 0.84 0.00
60_V 244_S 0.84 0.00
86_I 98_L 0.83 0.00
34_G 24_L 0.83 0.00
31_G 196_V 0.83 0.00
97_Y 253_L 0.82 0.00
202_R 223_S 0.82 0.00
86_I 123_A 0.81 0.00
111_K 180_G 0.81 0.00
221_A 157_A 0.81 0.00
28_S 202_A 0.81 0.00
41_L 156_A 0.81 0.00
216_S 63_I 0.80 0.00
119_P 27_C 0.80 0.00
35_C 197_V 0.79 0.00
38_I 112_F 0.79 0.00
94_L 228_M 0.79 0.00
12_T 197_V 0.79 0.00
197_R 116_L 0.78 0.00
27_F 24_L 0.78 0.00
114_D 68_L 0.78 0.00
175_M 202_A 0.77 0.00
214_T 250_L 0.77 0.00
40_A 221_V 0.77 0.00
34_G 29_T 0.76 0.00
207_N 15_L 0.76 0.00
150_P 93_Q 0.76 0.00
146_L 203_L 0.76 0.00
95_Q 181_H 0.75 0.00
133_V 69_I 0.74 0.00
174_L 228_M 0.74 0.00
126_R 249_F 0.74 0.00
150_P 237_A 0.74 0.00
140_L 228_M 0.74 0.00
85_D 124_I 0.74 0.00
233_V 28_M 0.74 0.00
136_I 239_S 0.74 0.00
58_D 162_R 0.74 0.00
21_Q 85_A 0.73 0.00
165_L 76_Q 0.73 0.00
183_E 135_A 0.73 0.00
220_A 251_D 0.73 0.00
136_I 123_A 0.73 0.00
213_C 42_L 0.73 0.00
220_A 160_L 0.73 0.00
64_L 27_C 0.73 0.00
125_L 197_V 0.73 0.00
90_V 132_M 0.73 0.00
71_V 203_L 0.72 0.00
190_F 108_Y 0.72 0.00
163_R 238_R 0.72 0.00
220_A 42_L 0.72 0.00
130_L 145_D 0.72 0.00
89_A 83_R 0.72 0.00
120_S 257_T 0.71 0.00
141_P 171_T 0.71 0.00
201_P 255_Q 0.71 0.00
249_T 57_A 0.71 0.00
68_F 148_D 0.71 0.00
133_V 124_I 0.71 0.00
104_L 184_I 0.71 0.00
125_L 234_R 0.71 0.00
111_K 171_T 0.70 0.00
175_M 110_R 0.70 0.00
54_R 250_L 0.70 0.00
215_L 228_M 0.70 0.00
72_R 204_S 0.70 0.00
110_A 27_C 0.70 0.00
122_V 209_A 0.70 0.00
28_S 40_T 0.70 0.00
250_L 60_F 0.70 0.00
237_K 179_D 0.70 0.00
150_P 20_Q 0.70 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

Page generated in 0.0944 seconds.