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OPENSEQ.org

HIS4 - HIS5
UniProt: P10371 - P60595
Length: 441
Sequences: 1294
Seq/Len: 2.96
I_Prob: 0.00

HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: HIS4 HIS6
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
Paralog alert: 0.89 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HIS5 PABA
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
142_V 80_M 0.87 0.00
224_V 190_L 0.83 0.00
210_D 141_F 0.80 0.00
190_V 6_L 0.79 0.00
222_V 166_A 0.76 0.00
167_H 183_G 0.75 0.00
99_V 9_G 0.74 0.00
115_W 50_A 0.74 0.00
103_S 14_N 0.73 0.00
151_V 68_A 0.73 0.00
67_T 35_V 0.71 0.00
103_S 68_A 0.71 0.00
3_I 163_F 0.69 0.00
40_A 122_Y 0.68 0.00
188_E 188_K 0.67 0.00
91_L 87_S 0.67 0.00
153_L 52_A 0.67 0.00
226_R 139_F 0.66 0.00
200_Q 10_C 0.66 0.00
175_R 85_R 0.65 0.00
175_R 51_Q 0.65 0.00
26_D 70_T 0.65 0.00
193_R 61_E 0.65 0.00
188_E 132_G 0.65 0.00
149_S 42_L 0.65 0.00
83_R 101_E 0.65 0.00
38_Y 174_G 0.64 0.00
43_A 101_E 0.64 0.00
202_S 15_S 0.64 0.00
45_V 95_L 0.63 0.00
123_A 175_V 0.63 0.00
211_V 174_G 0.63 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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