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OPENSEQ.org

HIS4 - HIS8
UniProt: P10371 - P06986
Length: 601
Sequences: 837
Seq/Len: 1.42
I_Prob: 0.01

HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: HIS4 HIS6
HIS8 - Histidinol-phosphate aminotransferase
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
155_Q 321_L 1.28 0.01
99_V 150_V 1.15 0.01
31_P 159_T 1.08 0.01
124_L 337_T 0.90 0.00
209_D 138_Q 0.87 0.00
161_L 171_L 0.87 0.00
82_V 331_S 0.86 0.00
162_P 351_L 0.85 0.00
76_V 69_Q 0.85 0.00
209_D 62_A 0.84 0.00
236_K 349_D 0.82 0.00
101_V 134_Q 0.81 0.00
126_L 76_E 0.81 0.00
231_G 103_I 0.79 0.00
119_F 142_D 0.79 0.00
141_A 109_T 0.78 0.00
211_V 254_A 0.77 0.00
65_I 324_Q 0.77 0.00
18_Q 183_A 0.77 0.00
137_N 170_T 0.77 0.00
86_E 142_D 0.77 0.00
188_E 230_E 0.76 0.00
205_I 120_I 0.76 0.00
10_D 62_A 0.76 0.00
99_V 207_A 0.75 0.00
74_V 223_C 0.75 0.00
205_I 297_T 0.75 0.00
92_L 46_Q 0.74 0.00
119_F 180_I 0.74 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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