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OPENSEQ.org
HCAE - HCAF
UniProt: P0ABR5 - Q47140
Length: 625
Sequences: 424
Seq/Len: 0.71
I_Prob: 0.34
HCAE - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
Paralog alert: 0.32 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: HCAE YEAW 		HCAF - 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
Paralog alert: 0.28 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: HCAF
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
2bmoA:BContact Map
2gbwAEC:BDFContact Map
3gzxA:BContact Map
1uliAEC:BDFContact Map
2b1xAEC:BDFContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
52_I 12_R 1.93 0.34
58_F 104_I 1.53 0.13
426_Q 147_D 1.39 0.09
347_D 57_K 1.38 0.08
187_I 16_F 1.26 0.06
30_I 12_R 1.19 0.04
29_D 13_I 1.18 0.04
58_F 102_C 1.17 0.04
29_D 112_V 1.15 0.04
112_Y 103_Q 1.14 0.04
309_I 24_L 1.11 0.03
58_F 26_D 1.10 0.03
171_A 57_K 1.08 0.03
28_P 113_F 1.07 0.03
294_R 99_I 1.06 0.03
80_A 78_I 1.06 0.03
165_D 19_H 1.05 0.03
289_A 147_D 1.04 0.03
407_G 97_H 1.03 0.02
54_K 150_R 1.03 0.02
54_K 38_E 1.02 0.02
351_A 56_R 1.01 0.02
302_R 42_Y 1.00 0.02
24_I 150_R 1.00 0.02
47_A 99_I 0.99 0.02
131_G 152_L 0.98 0.02
33_L 147_D 0.98 0.02
363_P 84_G 0.97 0.02
36_E 34_A 0.97 0.02
46_L 13_I 0.97 0.02
348_E 37_D 0.97 0.02
420_A 97_H 0.96 0.02
430_D 34_A 0.96 0.02
114_I 118_N 0.95 0.02
92_V 31_D 0.94 0.02
359_R 76_R 0.94 0.02
60_N 88_A 0.94 0.02
28_P 147_D 0.93 0.02
25_Y 121_L 0.93 0.02
74_K 146_D 0.93 0.02
396_M 96_R 0.92 0.02
24_I 78_I 0.91 0.01
69_V 13_I 0.91 0.01
293_Q 149_W 0.91 0.01
172_W 71_K 0.90 0.01
51_Q 43_T 0.90 0.01
320_A 42_Y 0.90 0.01
52_I 163_I 0.90 0.01
401_E 84_G 0.90 0.01
158_T 37_D 0.89 0.01
362_G 84_G 0.89 0.01
141_E 100_S 0.89 0.01
164_R 70_T 0.89 0.01
357_A 168_L 0.89 0.01
92_V 38_E 0.89 0.01
320_A 40_I 0.88 0.01
309_I 38_E 0.87 0.01
141_E 138_F 0.87 0.01
165_D 31_D 0.86 0.01
120_D 83_T 0.86 0.01
164_R 38_E 0.86 0.01
190_G 135_G 0.86 0.01
205_E 29_F 0.86 0.01
106_P 83_T 0.86 0.01
27_D 143_R 0.85 0.01
368_E 167_N 0.85 0.01
162_G 14_S 0.85 0.01
339_C 97_H 0.85 0.01
422_R 155_D 0.85 0.01
100_T 161_A 0.85 0.01
63_M 113_F 0.85 0.01
323_R 80_R 0.84 0.01
112_Y 22_S 0.84 0.01
407_G 100_S 0.84 0.01
194_W 80_R 0.84 0.01
165_D 74_L 0.84 0.01
286_E 38_E 0.84 0.01
329_G 152_L 0.83 0.01
232_S 130_E 0.83 0.01
157_D 59_V 0.83 0.01
36_E 40_I 0.83 0.01
147_S 31_D 0.83 0.01
212_Y 84_G 0.82 0.01
166_Y 12_R 0.82 0.01
27_D 160_Q 0.82 0.01
409_P 78_I 0.82 0.01
386_R 13_I 0.82 0.01
139_L 118_N 0.82 0.01
52_I 13_I 0.82 0.01
366_F 171_L 0.82 0.01
139_L 100_S 0.82 0.01
29_D 37_D 0.82 0.01
425_Y 69_D 0.82 0.01
27_D 14_S 0.81 0.01
129_P 150_R 0.81 0.01
361_F 80_R 0.81 0.01
347_D 120_L 0.81 0.01
71_V 132_F 0.81 0.01
432_L 119_Y 0.81 0.01
237_G 78_I 0.81 0.01
69_V 105_S 0.81 0.01
415_I 117_V 0.81 0.01
109_G 91_P 0.81 0.01
431_L 28_K 0.81 0.01
223_Q 79_A 0.81 0.01
29_D 142_R 0.81 0.01
418_E 86_A 0.80 0.01
146_E 34_A 0.80 0.01
63_M 118_N 0.80 0.01
58_F 30_R 0.80 0.01
39_F 109_I 0.80 0.01
47_A 59_V 0.80 0.01
28_P 107_T 0.80 0.01
59_F 100_S 0.80 0.01
46_L 116_R 0.80 0.01
78_I 131_T 0.79 0.01
231_G 30_R 0.79 0.01
369_Q 139_D 0.79 0.01
71_V 27_W 0.79 0.01
29_D 102_C 0.79 0.01
428_W 135_G 0.79 0.01
329_G 39_E 0.79 0.01
54_K 148_N 0.79 0.01
289_A 39_E 0.78 0.01
161_P 34_A 0.78 0.01
335_V 13_I 0.78 0.01
70_V 81_L 0.78 0.01
373_E 134_V 0.78 0.01
417_S 135_G 0.78 0.01
111_S 38_E 0.78 0.01
97_C 100_S 0.78 0.01
368_E 139_D 0.78 0.01
396_M 84_G 0.78 0.01
332_Q 99_I 0.77 0.01
63_M 17_L 0.77 0.01
174_L 163_I 0.77 0.01
80_A 36_L 0.77 0.01
331_D 146_D 0.77 0.01
351_A 171_L 0.77 0.01
47_A 116_R 0.77 0.01
329_G 50_A 0.77 0.01
33_L 146_D 0.77 0.01
147_S 103_Q 0.77 0.01
348_E 34_A 0.76 0.01
347_D 144_L 0.76 0.01
329_G 154_R 0.76 0.01
166_Y 36_L 0.76 0.01
380_K 45_R 0.76 0.01
163_L 103_Q 0.76 0.01
41_R 142_R 0.76 0.01
92_V 71_K 0.76 0.01
19_R 23_L 0.75 0.01
132_L 76_R 0.75 0.01
175_D 16_F 0.75 0.01
238_D 121_L 0.75 0.01
111_S 152_L 0.75 0.01
29_D 12_R 0.75 0.01
410_G 44_M 0.75 0.01
152_I 46_T 0.75 0.01
170_I 154_R 0.75 0.01
151_L 43_T 0.75 0.01
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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