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OPENSEQ.org
TRPA - TRPB
UniProt: P0A877 - P0A879
Length: 665
Sequences: 1081
Seq/Len: 1.66
I_Prob: 0.99
TRPA - Tryptophan synthase alpha chain
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: TRPA 		TRPB - Tryptophan synthase beta chain
Paralog alert: 0.73 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4ht3B:AContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
58_L 174_L 2.54 0.99
108_N 275_R 2.23 0.98
135_E 8_Y 1.98 0.95
103_A 278_I 1.91 0.94
107_F 283_K 1.67 0.88
77_T 291_D 1.41 0.71
65_Q 172_E 1.35 0.66
107_F 278_I 1.34 0.66
134_E 22_M 1.32 0.63
79_A 291_D 1.32 0.63
58_L 197_Y 1.29 0.61
58_L 18_P 1.23 0.54
78_P 291_D 1.18 0.48
33_S 60_T 1.05 0.34
180_A 182_E 1.02 0.31
79_A 290_E 0.94 0.24
43_A 314_A 0.93 0.22
54_F 294_I 0.93 0.22
232_I 18_P 0.91 0.20
129_A 18_P 0.89 0.19
136_S 309_V 0.89 0.19
157_N 20_I 0.88 0.18
214_I 139_V 0.86 0.17
59_A 85_A 0.83 0.14
85_L 48_L 0.78 0.12
159_D 23_P 0.78 0.12
158_A 143_S 0.78 0.12
180_A 123_S 0.78 0.11
157_N 181_Y 0.77 0.11
192_P 327_I 0.76 0.10
162_L 90_Q 0.75 0.10
177_L 20_I 0.75 0.10
205_A 99_K 0.74 0.10
65_Q 175_R 0.74 0.10
79_A 374_V 0.74 0.10
37_I 16_Y 0.74 0.10
123_V 333_L 0.74 0.09
179_R 279_Y 0.73 0.09
54_F 210_E 0.73 0.09
178_S 284_A 0.73 0.09
219_Q 207_M 0.72 0.09
169_Y 258_G 0.72 0.09
231_A 95_A 0.72 0.09
256_K 352_S 0.71 0.08
107_F 284_A 0.71 0.08
129_A 81_L 0.71 0.08
28_P 107_I 0.71 0.08
178_S 107_I 0.71 0.08
236_A 244_F 0.70 0.08
210_Q 64_N 0.70 0.08
138_P 283_K 0.70 0.08
76_V 16_Y 0.69 0.07
58_L 286_M 0.69 0.07
215_S 340_C 0.69 0.07
166_I 139_V 0.69 0.07
123_V 53_A 0.69 0.07
157_N 147_F 0.69 0.07
182_V 123_S 0.68 0.07
92_H 190_T 0.68 0.07
4_Y 174_L 0.68 0.07
58_L 279_Y 0.68 0.07
125_S 90_Q 0.68 0.07
62_P 243_D 0.68 0.07
23_V 9_F 0.68 0.07
134_E 26_R 0.68 0.07
215_S 18_P 0.67 0.07
218_D 213_K 0.67 0.07
45_A 287_M 0.67 0.07
129_A 282_M 0.67 0.07
67_A 12_F 0.67 0.06
54_F 388_H 0.67 0.06
209_L 296_E 0.66 0.06
127_L 57_T 0.66 0.06
21_P 49_L 0.66 0.06
196_L 53_A 0.66 0.06
37_I 190_T 0.66 0.06
193_L 254_G 0.66 0.06
116_A 367_D 0.66 0.06
111_I 174_L 0.66 0.06
170_G 123_S 0.65 0.06
58_L 170_C 0.65 0.06
48_L 369_E 0.65 0.06
266_T 314_A 0.65 0.06
51_G 279_Y 0.65 0.06
215_S 24_A 0.65 0.06
35_K 30_E 0.65 0.06
179_R 297_S 0.64 0.06
105_L 7_P 0.64 0.06
180_A 297_S 0.64 0.06
236_A 195_H 0.64 0.06
4_Y 359_L 0.64 0.06
68_T 286_M 0.64 0.06
159_D 26_R 0.64 0.06
237_I 20_I 0.64 0.06
155_P 352_S 0.64 0.05
109_K 268_G 0.64 0.05
179_R 280_F 0.64 0.05
143_A 91_V 0.63 0.05
120_K 157_I 0.63 0.05
51_G 148_R 0.63 0.05
107_F 282_M 0.63 0.05
237_I 312_Q 0.63 0.05
236_A 223_L 0.63 0.05
227_G 268_G 0.63 0.05
163_L 23_P 0.63 0.05
157_N 300_I 0.62 0.05
113_E 341_L 0.62 0.05
212_F 255_V 0.62 0.05
67_A 191_A 0.62 0.05
240_I 358_A 0.62 0.05
180_A 20_I 0.62 0.05
101_M 53_A 0.62 0.05
28_P 56_P 0.62 0.05
238_V 91_V 0.62 0.05
220_V 200_I 0.62 0.05
80_Q 16_Y 0.61 0.05
214_I 291_D 0.61 0.05
48_L 238_I 0.61 0.05
182_V 129_K 0.61 0.05
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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