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OPENSEQ.org

PYRB - PYRI
UniProt: P0A786 - P0A7F3
Length: 464
Sequences: 294
Seq/Len: 0.64
I_Prob: 0.00

PYRB - Aspartate carbamoyltransferase catalytic chain
Paralog alert: 0.85 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: OTC1 OTC2 PYRB YGEW
PYRI - Aspartate carbamoyltransferase regulatory chain
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PYRI
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
1pg5A:BContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
265_L 86_I 1.58 0.00
262_M 53_M 1.51 0.00
96_I 142_E 1.51 0.00
240_E 9_V 1.51 0.00
25_L 11_A 1.36 0.00
294_I 116_S 1.31 0.00
137_T 46_L 1.30 0.00
133_N 43_T 1.29 0.00
265_L 137_K 1.26 0.00
137_T 82_T 1.25 0.00
300_L 62_E 1.25 0.00
89_L 121_V 1.22 0.00
176_A 17_V 1.21 0.00
18_R 106_V 1.20 0.00
264_V 106_V 1.17 0.00
12_S 76_L 1.17 0.00
156_L 93_G 1.16 0.00
204_D 61_I 1.16 0.00
45_I 69_D 1.13 0.00
115_L 58_L 1.10 0.00
182_G 108_V 1.10 0.00
88_T 120_P 1.10 0.00
113_A 76_L 1.10 0.00
117_T 90_E 1.09 0.00
69_A 144_E 1.08 0.00
233_K 12_I 1.07 0.00
60_F 59_I 1.07 0.00
69_A 24_Q 1.07 0.00
16_L 62_E 1.05 0.00
212_L 93_G 1.05 0.00
140_L 63_N 1.04 0.00
258_A 23_A 1.03 0.00
154_D 98_S 1.03 0.00
251_R 9_V 1.03 0.00
132_S 105_N 1.02 0.00
60_F 6_K 1.02 0.00
258_A 150_V 1.02 0.00
149_T 48_L 1.02 0.00
192_A 129_K 1.01 0.00
174_T 52_E 1.01 0.00
180_F 22_P 1.00 0.00
62_T 55_R 1.00 0.00
298_Q 24_Q 1.00 0.00
244_V 85_R 0.99 0.00
257_N 88_N 0.98 0.00
203_L 7_L 0.98 0.00
11_I 63_N 0.98 0.00
188_I 67_S 0.97 0.00
184_R 13_K 0.97 0.00
112_A 23_A 0.97 0.00
256_H 68_E 0.97 0.00
137_T 62_E 0.96 0.00
67_L 59_I 0.96 0.00
35_P 27_F 0.95 0.00
41_K 12_I 0.95 0.00
253_S 7_L 0.95 0.00
145_T 72_D 0.94 0.00
133_N 142_E 0.94 0.00
294_I 7_L 0.94 0.00
28_A 54_G 0.94 0.00
294_I 27_F 0.94 0.00
218_E 31_S 0.94 0.00
152_R 83_V 0.93 0.00
183_N 26_G 0.93 0.00
205_E 13_K 0.93 0.00
259_K 90_E 0.93 0.00
82_L 75_A 0.93 0.00
287_F 82_T 0.93 0.00
263_K 63_N 0.93 0.00
195_M 11_A 0.92 0.00
259_K 93_G 0.92 0.00
113_A 117_H 0.92 0.00
112_A 125_F 0.92 0.00
145_T 24_Q 0.92 0.00
108_P 57_D 0.92 0.00
117_T 12_I 0.92 0.00
301_L 53_M 0.91 0.00
71_V 83_V 0.91 0.00
233_K 86_I 0.91 0.00
290_A 103_I 0.91 0.00
46_A 53_M 0.91 0.00
260_A 96_R 0.90 0.00
153_L 97_P 0.90 0.00
220_M 29_L 0.90 0.00
254_D 66_L 0.90 0.00
126_L 126_A 0.90 0.00
301_L 38_T 0.90 0.00
137_T 73_Q 0.89 0.00
300_L 57_D 0.89 0.00
161_V 75_A 0.89 0.00
180_F 41_R 0.89 0.00
75_S 88_N 0.89 0.00
141_L 78_A 0.89 0.00
178_A 28_K 0.88 0.00
24_V 66_L 0.88 0.00
278_V 86_I 0.88 0.00
275_A 61_I 0.88 0.00
233_K 28_K 0.88 0.00
39_L 59_I 0.88 0.00
137_T 107_L 0.88 0.00
256_H 96_R 0.88 0.00
272_D 48_L 0.87 0.00
4_P 116_S 0.87 0.00
16_L 144_E 0.87 0.00
199_I 75_A 0.87 0.00
18_R 52_E 0.87 0.00
183_N 89_Y 0.87 0.00
211_S 51_G 0.87 0.00
154_D 61_I 0.86 0.00
43_K 69_D 0.86 0.00
218_E 13_K 0.86 0.00
199_I 103_I 0.86 0.00
188_I 122_S 0.86 0.00
104_V 53_M 0.86 0.00
217_E 49_P 0.86 0.00
18_R 130_R 0.86 0.00
206_K 14_R 0.86 0.00
187_F 45_G 0.86 0.00
188_I 58_L 0.85 0.00
259_K 59_I 0.85 0.00
292_N 83_V 0.85 0.00
217_E 61_I 0.85 0.00
161_V 136_L 0.85 0.00
271_V 105_N 0.85 0.00
50_F 143_K 0.85 0.00
115_L 26_G 0.85 0.00
104_V 23_A 0.85 0.00
214_S 96_R 0.85 0.00
21_L 87_D 0.85 0.00
292_N 48_L 0.85 0.00
264_V 55_R 0.85 0.00
260_A 148_N 0.84 0.00
207_G 135_A 0.84 0.00
264_V 25_I 0.84 0.00
260_A 61_I 0.84 0.00
189_A 24_Q 0.84 0.00
166_Y 123_S 0.84 0.00
22_N 57_D 0.84 0.00
282_P 119_E 0.84 0.00
244_V 16_T 0.84 0.00
7_Q 61_I 0.84 0.00
183_N 9_V 0.84 0.00
166_Y 113_N 0.84 0.00
115_L 105_N 0.84 0.00
52_A 112_S 0.83 0.00
292_N 91_V 0.83 0.00
69_A 150_V 0.83 0.00
240_E 76_L 0.83 0.00
117_T 130_R 0.83 0.00
197_Q 135_A 0.83 0.00
157_H 86_I 0.83 0.00
243_N 39_D 0.83 0.00
93_I 80_Q 0.83 0.00
159_A 142_E 0.83 0.00
94_S 27_F 0.83 0.00
238_P 36_T 0.83 0.00
8_K 99_L 0.83 0.00
144_F 29_L 0.82 0.00
62_T 9_V 0.82 0.00
149_T 45_G 0.82 0.00
233_K 131_A 0.82 0.00
5_L 99_L 0.82 0.00
66_R 76_L 0.82 0.00
245_K 8_Q 0.82 0.00
247_Q 57_D 0.82 0.00
233_K 73_Q 0.82 0.00
26_A 37_E 0.82 0.00
212_L 33_F 0.81 0.00
202_M 27_F 0.81 0.00
180_F 21_I 0.81 0.00
155_N 90_E 0.81 0.00
25_L 27_F 0.81 0.00
126_L 135_A 0.81 0.00
144_F 145_F 0.81 0.00
3_N 150_V 0.81 0.00
50_F 124_S 0.81 0.00
179_K 116_S 0.81 0.00
165_K 17_V 0.81 0.00
44_V 44_I 0.81 0.00
102_A 124_S 0.81 0.00
181_D 61_I 0.81 0.00
263_K 9_V 0.80 0.00
238_P 66_L 0.80 0.00
4_P 24_Q 0.80 0.00
207_G 91_V 0.80 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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