>seq_1
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKL
TEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
>tr|A0A0F8AQ71|A0A0F8AQ71_LARCR General transcription factor IIH subunit 2 OS=Larimichthys crocea GN=EH28_10942 PE=4 SV=1
-SRILNGIVAVCPDLGIGNNGKLPWHPVRNEFKHFRTMTETPSAKGKQNVVIMGRKTWFSIPEKNRPLNNRINIVLSRQCKAPPAGAHHLVADFNSALRL
VD-TDLADQADQVWIIGGSSLYKELMESSGTRRLFITQILKQFECDTFFPEISPDKFRLLPN-------------------------
>tr|A0A097A5T8|A0A097A5T8_PNEJI Dihydrofolate reductase OS=Pneumocystis jiroveci GN=DHFR PE=3 SV=1
----TL-IVALTYSRGIGLKNDLPWK-LKSDMMFFSRVTSGLLVTGQMNVVLMGRKTWESLPAHSRPLKNRINVVISRQEVLDLGGGAYHARSLDDALAL
LSQIYSKIQLNRVFVIGGGELYKAAMEHSRLNRIIATVIHNEVDCDV----------------------------------------
>tr|M7NWY1|M7NWY1_PNEMU Dihydrofolate reductase OS=Pneumocystis murina (strain B123) GN=PNEG_00209 PE=3 SV=1
----TL-IVALTTSYGIGRSNSLPWK-LKKEMVYFKRVTSFVPAFEWMNVVLMGRKTWESLPLQFRPLKGRINVVISREESLDLGQGIHCARSLDDALEL
LSCIYNPIQVNRIFVIGGAQLYKAAMEHPRLNRIIATIIYKDVNCDV----------------------------------------
>tr|Q548M5|Q548M5_PNECA Dihydrofolate reductase OS=Pneumocystis carinii GN=DHFR PE=3 SV=1
----TL-IVALTTSYGIGRSNSLPWK-LKKEISYFKRVTSFVPTFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALEL
LYRTYSSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDV----------------------------------------
>tr|M2RUF7|M2RUF7_CERS8 Uncharacterized protein OS=Ceriporiopsis subvermispora (strain B) GN=CERSUDRAFT_129428 PE=3 SV=1
----LTVIVAATLTNGIGQNTRLPWR-LPREMAYFARITTHAPE-GAMNAVVMGRNTWESIPRKFRPLPKRVNIVISSNKQYELMPPVYLHSNLDSALDR
LSHSEIESPIHRSFVIGGASLYGETLALPPVDRVLLTRILSAFDCDV----------------------------------------
>tr|J4H590|J4H590_9APHY Uncharacterized protein OS=Fibroporia radiculosa GN=FIBRA_08576 PE=3 SV=1
----LTLVVAATLTNGIGHNARLPWR-LSSELKYFAQVTSAAPA-GHANAVLMGRNTWESIPLRFRPLPRRINVVVSTDRHYQLMPPVYLHSSLETALER
LTHAELESPVHRAFVVGGAALYRDTLALPPVDRILLTRIIAEFQCDV----------------------------------------
>tr|K5XDG7|K5XDG7_PHACS Uncharacterized protein OS=Phanerochaete carnosa (strain HHB-10118-sp) GN=PHACADRAFT_82332 PE=3 SV=1
----LSLIVAATVSNGIGQSSRLPWR-LPQEMTYFARITSGAPE-GTKNAVVMGRKTWESIPAKFRPLRDRLNVVISRNQDYQLQTSVRLNADLPSALTE
LSMQDEKTDVNRVFIIGGATLYKETLELPPVDRVLLTRILSSFECDV----------------------------------------
>tr|A0A059WTK2|A0A059WTK2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
IDAESAIIVAVDECYGFGKDGKIPWHF-KEDFQYFKKMTKG-------ATCVMGRKTYEDLLGYDELLPGRKCYVVTSSEEP---LQKGALSDPYED-L-
----PEDCVGGPVFYIGGAGIFDAALD--FVDEVYMTHIRRNYDCDVSFPYAKLEEKFQLADNPYAPVLDQ---ELTLLFERWVRK-
>tr|K9UIS2|K9UIS2_9CHRO Dihydrofolate reductase OS=Chamaesiphon minutus PCC 6605 GN=Cha6605_3318 PE=3 SV=1
-MVQKILIAAIDKDGGIGKDGYMPWHY-PADLKLFMNLTMG-------HTIVMGRKTFDGMFDR-APLKGRQNIVVTSQAEKYRSRFTPTTDLNCGDIE-
------LEADAKIFYCGGANIYQQVIQRLDLDIIYLSRLDESYDCDTFFPQNPQSSDGEF--PPYLTQSFSDKMSGPFTFQIYTPK-
>tr|A0A0N9MWZ9|A0A0N9MWZ9_9BACT Dihydrofolate reductase OS=uncultured bacterium GN=dfrA23 PE=4 SV=1
-MPTVEIIVAVDPVGGFGRNGQIPWTC-KEDMKRFTTISKEI------RVCVMGKNTYKDMLDMKGILPERESYVVSSTLKPE--DVIGAVPDLRAVLN-
----QYHDSDQRIAVIGGEKLYVQALA--SATKVHMTVMHKPYNCDRTLPMSYIDKKFVAI---TIQTAVD---GEPVKFITYERA-
>tr|A0A013IVN5|A0A013IVN5_ACIBA Dihydrofolate reductase family protein OS=Acinetobacter baumannii 1413735 GN=J675_4022 PE=3 SV=1
SHPQLELIVAVDSKLGFGKGGKIPWKC-KEDMARFTRISKEI------RVCVMGKHTYTDMRDMKGILPERESFVISSTLKQE--DVIGAVPDLRAVIN-
----LYENTDQRIAVIGGEKLYIQALS--SATKLHMTIIPREFDCDRFIPVDPIQNNFHIE---TVEATVD---ETRIHFATYVRN-
>tr|A0A0F9E6G7|A0A0F9E6G7_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_2113050 PE=4 SV=1
VPRELNIIVCVDNRLGFVKNGRIPWNF-KKDFKHFQKTTKE-------HYCIMGRGTFEDMMRMESPLPGRTPIVLSRNPNY---TANGMFSDLRQATD-
----SLDDKEKKIFILGGSKLWIEALP--DTTTIYMTMIDRSYDCDQFFPGCGIHPDYLAVDGKKVKTSRR---KDELTFLEMKRC-
>tr|A0A0F3R7V4|A0A0F3R7V4_9RICK RPE1 domain protein OS=Rickettsia endosymbiont of Ixodes pacificus GN=REIP_0354 PE=4 SV=1
KNRKIIGIMACDPQGVIGNKGQIPWSY-SKEFEYFYQTVKN-------NIIVMGRKTFDSIPAKNTPLQSYNNRHLS--KPTYREEFKGILDDFWQIIK-
------PFTDKKIFMVGGTEIATLFLEQNLIDEFLLTKINKNYDGDTFFPLNLLAEWHSV--------------DKTNNYQIYKFT-
>tr|H3ADL5|H3ADL5_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=DHFR PE=4 SV=1
AARLLNSIVAVCPNLGIGKDGNLPWHPKSNEFRYFQKMTTTPTVEGKQNVVIMGRKTWFSIPEKNRPLKGRVNVVLSRELQEAPEGAHY-ARDLDSALKL
LESPELADRVDLVWIIGGSALYKEALEHPSQHRLFVTRVLQQFECDTYLPEINFNKFTLL---FIRIAAVRLGQR--STFLKAELP-
>tr|M3XI69|M3XI69_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=DHFR PE=4 SV=1
AARLLNSIVAVCPNLGIGKDGNLPWHPKSNEFRYFQKMTTTPTVEGKQNVVIMGRKTWFSIPEKNRPLKGRVNVVLSRELQEAPEGAHY-ARDLDSALKL
LESPELADRVDLVWIIGGSALYKEALEHPSQHRLFVTRVLQQFECDTYLPEINFNKFTLL---PGVSSAIQEESGIQYKFEVYEKN-
>tr|B5X910|B5X910_SALSA Dihydrofolate reductase OS=Salmo salar GN=DYR PE=2 SV=1
MSRVPNCIVAVCPDVGIGNNGNLPWHPKNNEFKYFQKMTMTSSVEGKQNVVIMGRKTWFSIPERNRPLKNRINIVLSRELKKPPAGAHH-ASDFRSALCL
LDMAEMAERADQVWVIGGSSLYKEMMESQGTRRLFVTRILQQFKSDTFLPEINQDQYRLL---PGVPQDLQEEAGLQYRFEVYESI-
>tr|Q6IQS4|Q6IQS4_DANRE Dihydrofolate reductase OS=Danio rerio GN=dhfr PE=2 SV=1
MSRILNCIVAVCPDMGIGKNGNLPWHPISNELKHFQKMTMTPSDEGKKNVVIMGRKTWFSIPAAHRPLKNRINIVLSRELKTAPEGAHY-ASDFSSALHL
LDSGELEKLVDQVWIIGGSSLYKEVMERSGHRRLFVTRILKQFDCDTFIPNFDMDKYKLL---PGVPVGLQEDNGVQYLFEVYESI-
>tr|C1BZA4|C1BZA4_ESOLU Dihydrofolate reductase OS=Esox lucius GN=DYR PE=2 SV=1
MSRVLNCIVAVCPNMGIGNKGNLPWHPKNNEFKYFQKMTMTPFVEGKQNVDIMGRKTWFSIPERNRPLKNRINIVLSRELKEPPPGAHH-ASDFSSALRL
LDTAEMAERVDQVWVIGGSSLYKEMMESEGIRRLFVTRILQQFESDTFLPEINQDKYRLL---PGVPQDVQEESGIQYRFEVYESV-
>tr|W5U7R4|W5U7R4_ICTPU Dihydrofolate reductase OS=Ictalurus punctatus GN=Dhfr PE=2 SV=1
MGRVLNCIVAVCPDMGIGRNGNLPWHPISKEFKHFQKMTMTPTVEGKKNVVIMGRKTWFSIPAQNRPLKNRINVVLSRELKTAPEGAHY-AADFSSALRI
LENAELEAQADQVWIIGGSSLYKEVMESSAHQRLFVTRILKQFDCDTFIPNIDLDKFRLL---PGVPAGLQEENGLQYVFEVYESV-
>tr|W5MD25|W5MD25_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
MPRPINCIVAVCPNMGIGHNGNLPWHPKSNEFKYFQKMTMTPTLEGQQNAVIMGRKTWFSIPERNRPLKNRINIVLSRELKNPPEGAHY-ASDFSSALRL
LDSAPQTDQVDQVWVIGGSSVYKEAMEAPGWCRLFVTQILQDFECDTFLPEINLNKYRLL---PGVPLEVQEENGIRYKFEVYESI-
>tr|A0A0K2FGK7|A0A0K2FGK7_9CAUD Dihydrofolate reductase OS=Enterobacter phage phiEap-3 GN=ADS69_00060 PE=3 SV=1
KAVFALGHDIYHDDFAFGYQQGLPWGHCKEDLQNFKEETAD-------SVLIMGANTFTSLPGK---LPGRIHCVLSGSGSFLKTK-KGVGGGLSAAIGT
---MQATHPDKNVCVIGGKGLLLDSINNKMVDEVVLTHIYGHYNAPSFKR----DVSFTA-----------------DALLKYEFT-
>tr|A0A0M3UL84|A0A0M3UL84_9CAUD Dihydrofolate reductase OS=Citrobacter phage Margaery GN=CPT_Margaery64 PE=3 SV=1
KAVFAVGHDMYEVDYAFGYEQGLPWGHCKEDLQNFKEETAN-------SVLIMGANTFTSLPGK---LPGRIHCVLSGSGSFLKTK-KGVGGGLSAAIDV
---MKATHPDRDVCLIGGKGLLLEAINNTLVDEVVVTHIYGHFNAPAFKR----DVSFTV-----------------EAVLKYELS-
>tr|M9UV07|M9UV07_9CAUD Dihydrofolate reductase OS=Escherichia phage Lw1 GN=frd PE=3 SV=1
KAVFAVGNDAYEEDFAFGYQQGLPWGHCKEDLQKFKAETAN-------SVLIMGANTFTSLPGK---LSGRVHCVMSASGQRLVTK-NGICGGLSAAIDV
---MKATHPDSDVCIIGGKGLLLEAINNTLVDELVITHVYGHYNAPAFKR----DVSFSV-----------------DAVLKYGYC-
>tr|F4PBG6|F4PBG6_BATDJ Putative uncharacterized protein OS=Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) GN=BATDEDRAFT_91777 PE=3 SV=1
---SFNLIVAATPDGGIGYNGDMPWRL-PSDLDYFMRITTSFRRQANLNVVIMGRKTWFSIPKKFRPLQNRINVVLTSNESLKPTSPVYVFSDFQEALAS
IS--TGKSPIGSIFVMGGSQLYQSALYNPQCQIVFLTRVNTAIQCDTFIPSIPTDFRELGSKMPNVNLSQQSCGKFTFKHQVYVRNT
>tr|L0P7T1|L0P7T1_PNEJ8 Uncharacterized protein OS=Pneumocystis jiroveci (strain SE8) GN=PNEJI1_003856 PE=3 SV=1
---PIVGIVCLQPEMGIGFRGGLPWRL-PSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDKERSIVQSNSLANAIMN
LESF--KKHLERIYVIGGGEVYSQI--FSITDHWLITKINATPAMDTFLDAKKLEVFSEQDPF-----YSLEEKGYSAEFTLYNLIE
>tr|A3LSL9|A3LSL9_PICST Dihydrofolate reductase OS=Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) GN=DFR1 PE=3 SV=
---TIAIIVALKPDLAIGFQGKMPWRL-RKEIRYFKDVTTKTSDPSKINAVVMGRKTWDSIPARFRPLPDRINIVLSRSFQNE-DTNVIHANSIANSLSQ
LQ-----PNVERVFVIGGAEIYNELINDSRVTHLLLTEIN-QIAVDTFLKFPLYSQWRKQPKF------DISEGDLKYNYTLWTRRA
>tr|K0KX72|K0KX72_WICCF Putative dihydrofolate reductase-thymidylate synthase OS=Wickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM 
---QVSIIVALLPSFGIGYKNQLPWKL-RNEMKYFKNVTTNKSSTNSKNAVIMGRKTWDSIPSKFRPLPDRYNVILTKQDPTS-IENVKYSNNIDDTIKN
LL---NDDSINQIFIIGGSEIYNNSITNNLVDNLLITEI--EIEMDTFLNKDYILNFTKTNKF------KIIEGDFEYEFTLYKRK-
>tr|A0A0G0KDS8|A0A0G0KDS8_9BACT Dihydrofolate reductase OS=Parcubacteria bacterium GW2011_GWA1_38_7 GN=UT00_C0006G0065 PE=3 SV=1
---SYASPVTQDGKSVIGKNGDMPWRGKPSDMKRFVELTVG-------HSVVMGRKTWDSIPFKFRPLPNRQNIVLTRNPQFT-NSGVIVAHSLEEAVQQ
-------AKSETVWIIGGAEIYALA--LPVTDFLH-TTI--KFEGDAFFPKYNLSDWMNIY-F--------EKDTINSGYLIFKRK-
>tr|A0A0L0GEF3|A0A0L0GEF3_9EUKA Dihydrofolate reductase OS=Sphaeroforma arctica JP610 GN=SARC_00497 PE=3 SV=1
---KISLIVATAKDGGIGVKGNLPWRL-RGDMAFFKKTTTTA-P-GMRNAVIMGRKTWESIPSKFKPLADRLNIIVSSTMRTD--SGVLLGRSLEHSIEL
AMQTNGCNDIDRIFLIGGSTLYNSALQTPSIDKIHFTRVYGAFECDVFFADPESDRFD----VSEMQ---TE-KGCEYEFCEYTP--
>tr|G8ZMU1|G8ZMU1_TORDC Uncharacterized protein OS=Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) GN=TDEL0
---PVVAVVCMIPEMGIGFQGKLPWRL-ATEMKYFKEVTSTTKDPTKVNAVVMGRKTWESIPPRFRPLPNRINMVVSRQPRAQLDDQVYSTSSLSQGIEH
LNTF--GERLERIYIIGGAEIYSQS--YELVDHWLVTKISQVPEMDTHLDPQRLATFKERSLF-----NPIEEKGFHYWFTLYTNQR
>tr|C5DXQ4|C5DXQ4_ZYGRC ZYRO0F06930p OS=Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) GN=ZYRO0F06930g PE=3 
---PIVCIVALCPHMGIGYRGGLPWKL-SQEMKYFRQVTTSTFTEGKSNAVIMGRRTWESIPAKFRPLKGRINVVLSRQ--FPREDDRFLSNDLSHAIKS
LQDL---P-VERIYIIGGAQLYTES--IDIATHWLVTNIEQPPPVDTFLPRLTHH---EVSPF-----HYSMQDNFTYWYTLYESQN
>tr|J3JTN2|J3JTN2_DENPD Uncharacterized protein OS=Dendroctonus ponderosae PE=2 SV=1
---KLNLIVAASENWGIGKNGTLPWKL-KKEMAFFRTMTSATED-SKKNVVIMGRRTWESIPAQFKPLPNRINFVLSRSGLNL--SNTQSFTSFREALDK
LEESTFRQLYENVWIIGGSSLYNETFRSPHFHRLYLTKIHKEFDCDTFLPALPGNKEISDP-AEDIQ---EE-NDIEYTFQVFEVTN
>tr|Q75BZ5|Q75BZ5_ASHGO ACR124Wp OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=AGOS_ACR124W PE=3 SV=1
---PVVSIVCLLPEYGIGYQGQLPWRL-AREMKYFRQATTATFDPTKRNAVVMGRKTWESIPARWRPLPGRLNVVVSRTYTSP-NGHVITSNSLQQCVRQ
LQEA-RALGVERIYIMGGAEIYNQS--YDLCDHLLVTELGPAVLLDTFLARDVLESFAKNS-L-----TALEEGGFQFRFALYDHLN
>tr|R9XCZ3|R9XCZ3_ASHAC AaceriACR124Wp OS=Ashbya aceri GN=AACERI_AaceriACR124W PE=3 SV=1
---PVVSIVCLLPEYGIGYQGTLPWRL-AREMKYFRQATTATFDPAKRNAVVMGRKTWESIPARWRPLPGRLNVVVSRTYTSP-SGHVITSNSLQLCVRQ
LQEA-HALGVECIYIMGGAEIYNQC--YDLCDHMLVTELSPAVPMDTFLARDVVTLFARNA-L-----TALEEGGFQFRFALYDKVH
>tr|G8BVS6|G8BVS6_TETPH Uncharacterized protein OS=Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) GN=TPHA0G
---PVINVVCLLPNMGIGFQGGLPWRL-SKEMKFFKQLTTSTFDSSKKNVVIMGRKTWQSIPARFRPLPNRINVVLSRSYSSHEDNTHYVCNSLTESLKQ
IQDL--VDTVERIYIIGGSEIYNGS--FRLADHWLITKIEPAPMVDTFIKKDMLLYFKEDHEF-----YKQEEKGLEFGFSLWNKI-
>tr|A0A0B6Z6C9|A0A0B6Z6C9_9EUPU Uncharacterized protein (Fragment) OS=Arion vulgaris GN=ORF49983 PE=3 SV=1
---KLNVIVAACNNMGIGIEGRLPWRL-KQDMAFFKKITTTTQN-AKKNVVIMGKNTWLSIPAKFRPLSDRINIILSTQLQEK----AYLVSSFEKAMEL
I-S-SLHKDVESVFVIGGASVYKEAMQMPNPCRIFFTRVHSSFSCDTFFPDIDDNFKRLSTTIPETF---QE-NGIQFSFEIYDKS-
>tr|W0VH81|W0VH81_ZYGBA Related to DFR1-Dihydrofolate reductase OS=Zygosaccharomyces bailii ISA1307 GN=ZBAI_00543 PE=3 SV=1
---PVVCIVALMPQMGIGYRGALPWRL-RKEMQYFREVTTSTFDPSASNAVVMGRRTWESIPARFRPLRDRINVVLTTACDAPREHNLYESCDLSSAIAA
LQAM---PHCERIYVIGGAQLYAQA--RHLASHWLVTKIPDAVPIDTFLPDLSPC---LQSSF-----HYTTEQQFTYWYALYTRPQ
>tr|G0VBB0|G0VBB0_NAUCC Uncharacterized protein OS=Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) GN=NCAS0B01500 PE=3 
---PVVSIVCLVPEMGIGFQGNLPWRL-SKEMKYFRQVTSSTFDPAKKNAVIMGRKTWESIPARFRPLPNRINVVISRSFTDTLTDPYFKINSLSGCIDE
LTTM--TKDLERIYIIGGGEIYNEC--YNMADYWLITKLTVEPEMDTFLNTKTLKVFEEDK-F-----YHAQEKGYSFEFTFYNKR-
>tr|H2AN61|H2AN61_KAZAF Uncharacterized protein OS=Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-82
---PVVSIVALLPDMGIGFQQSLPWRL-SKEMKYFREVTSSTFDGGKQNAVIMGRKTWESIPSRFRPLPNRINVVLSRSFENGENKTYFQSSSLQRSIDS
LMSM--GEKLERIYIIGGSEIYNHA--FDVIDHVLITKLTVRPKMDTFLDVAKLNSFQEMN-F-----YIENENGYKFEFSLYSRK-
>tr|J7S268|J7S268_KAZNA Uncharacterized protein OS=Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBR
---PVVGIVALLPDLGIGFQGKLPWRL-SKEMKYFREVTSLTRDPQKTNAVVMGRKTWESIPARFRPLPNRINVVISRQFPETEDKETYKSNSLQLAIQQ
LQFL--GAQLERIYIIGGGEIYNQA--FDLVDYWLITKLIVKPVMDTFLNKDTLLKFQECSHF-----YSAEENGYVFHYSLYSRK-
>tr|Q6FPH0|Q6FPH0_CANGA Uncharacterized protein OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) GN=CAGL0J03894g PE=
---PVVGIVALLPEMGIGFQGNLPWRL-AKEMKYFREVTTLTNDNSKQNVVIMGRKTWESIPQKFRPLPKRINVVVSRSFDGEVEDGIYHSNSLRNCLTA
LQSLANENKIERIYIIGGGEIYRQS--MDLADHWLITKITTIPQMDTFLQKQELERFYDNS-F-----LPVQEKGYQFYFTLYTKK-
>tr|A7TKP4|A7TKP4_VANPO Putative uncharacterized protein OS=Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) GN=Kpol_1072p26 PE=3 SV=1
---PVVSIVCLLPEFGIGLQGTLPWRL-AKEMKFFRQVTSSTFDSGKQNAVIMGRKTWESIPAKFRPLPNRTNVVISRSFTADDDNSYLKCNSLYDSIEK
LNSY--KDKIERVYIIGGGEIYKES--LNLCDYWLITKIVPPPKVDTFLDSKTLSNYIEDKNF-----YAQQERGLEFGYSLWRKK-
>tr|W0T6I8|W0T6I8_KLUMA Dihydrofolate reductase OS=Kluyveromyces marxianus DMKU3-1042 GN=KLMA_20779 PE=3 SV=1
---PVCCVVCLMPGYGIGFQGTLPWKL-SKEMKYFRQLTSSTKDPKLQNAVIMGRKTWESIPSKFRPLPNRLNVVISRTEGVDTRHVSLSATDLSKAISQ
LTTS-ERLGLETIYIIGGGEIYNQC--IPLSDKLFLTKVTPAPQMDTFLDKHLVELFKEQPYA-----RFLSEKGFNYNFTLWSRDK
>tr|G8JP88|G8JP88_ERECY Uncharacterized protein OS=Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) GN=Ecym_2414 P
---QVVGIVCLIPEFGIGFRNQLPWKL-PRELKYFRQVTTETFDPAKRNAVIMGSKTWNSIPSKLKPLRDRLNVVISRSFASEGNCHVIHSNSLSGSIER
MKEA-EHLKLERIYVIGGAEIYSQC--YSLIDHLLITKIGNRIQTDVFLDSKKIHLFLQDE-F------SFTDNGLQVTFTLYDRK-
>tr|Q6CC38|Q6CC38_YARLI YALI0C12771p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12771g PE=3 SV=1
---STTLILATVPRYGIGLNGGLPWRL-AKEMKFFKQVTTAQKN----AVVIMGRTTWDSIPPKFRPLPDRTNIVLTSRPMTD------VARSFDEALTK
C------PEDSTVYVIGGSQVYKTALVHEHTKAVLLTEI-GHVECDTFFEGFDQ-LWKKQPYF-----TPVEEKGFSFVYTLWEK--
>tr|A0A0J9XJB7|A0A0J9XJB7_GEOCN Similar to Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase OS=Geotrichum candidum GN=BN980_GECA18s02342g PE=3 SV=
---QLTLILATTPKLGIGYNGTLPWHL-PSELKYFRAVTLQ-------QTVIMGRATWESIPPKFRPLPRRDNIIVSRSLAASTAPRTLFCDSLTAALAA
AA----ESPTKRIYIIGGAQLYNSVLQLASSPRVLMTEV-AEIPCDTFFTGFVP-QWQKQPHF-----GKIAENDYEFEFTYWTKRQ
>tr|A0A0F4X5T3|A0A0F4X5T3_HANUV Dihydrofolate reductase OS=Hanseniaspora uvarum DSM 2768 GN=HuDFR1 PE=3 SV=1
---PIVQVTCLMPDFGIGNKGKLPWRL-KKEMKYFKEVTTNTEDPTKKNAVLMGRKTWLSIPPKFRPLPDRLNIVLSRSSPNWQEEGMILCNNIHTAVSK
LNDESYYSDIERIYIIGGGEIYNST--YDICTHLLITEI-IKHEMDTFLNQSDITLFERCEDF-----SNINEGDYRYKYVLYKRK-
>tr|A0A0C7MXD0|A0A0C7MXD0_9SACH LALA0S01e03378g1_1 OS=Lachancea lanzarotensis GN=LALA0_S01e03378g PE=3 SV=1
---SIISIVCLMPEMGIGSNGQLPWRL-KQEMAYFRQATTNTFGKDTRNAVVMGRKTWESIPAKFRPLQNRINVVVSRQHSEETGSTVWLSNSLTRCLEL
LPEV---PNLERIYVIGGGEIYAQT--SSLCDYMLITEIAKRPSMDTFLDSNVVNRFQREE-F------QIRENGYVYEFALYKVRK
>tr|Q6CRP4|Q6CRP4_KLULA KLLA0D07458p OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=KLLA0_D07458
---SVCCVVCLMPGYGIGYQGSLPWRL-SKEMKYFRQLTSATRDSSMRNAVVMGRKTWESIPAKFRPLPNRLNVVVSRNCQLDGDDATLYAGDLSRAIDQ
LIAS-KILGLETIYIIGGGDIYRQC--IPMSHNLFITKIMPVPPMDTFLDREQIEQFKEQPHI-----PTISEKGFTYSFTLWSRDT
>tr|C5DEY6|C5DEY6_LACTC KLTH0D10802p OS=Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) GN=KLTH0D10802g PE=3 SV=1
---PIVTIVCLMPEMGIGYNGKLPWRL-KQEMAYFRQVTSATFADGKRNAVIMGRKTWESIPPKFRPLPDRVNVVVSRQFAEDASPALWLSNSLTRCLDL
LPQV---PDLERIYVIGGAEIYAQS--NSLCDYMLITKITERPPMDAFLDTQSIHLFQHDQ-F------YISENGYRYNFALYRRRS
>tr|I2GYN0|I2GYN0_TETBL Uncharacterized protein OS=Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 7
---PVINVVCLMPSYGIGYQGKLPWRL-KQEMAYFKQLTTNTRDPTKQNAVVMGRRTWESIPSRFRPLPSRLNVVVSRGFDTWPLSTYIGAPDLRSAITT
LQQA-QELRIERIYVMGGAQIYQAIAESGLLDHWLLTAVTPEPPMDTWLTAPSPDYILQTNEF-----FVHSEKGYAFGITLYDRRR
>tr|C4XYS3|C4XYS3_CLAL4 Putative uncharacterized protein OS=Clavispora lusitaniae (strain ATCC 42720) GN=CLUG_01096 PE=3 SV=1
---VTSVIVALSPKYGIGAQGKLPWRL-KQEMKYFKDVTSAAR-AGSINAVVMGRKTWESIPKKFRPLPNRLNIVLSRSFSN--KDGVLYFNSIDSIMSN
LAQWYHDKPIDKIFIIGGAEIYNSVMKGDLVDNLLVTNIEAEPVLDTFLDWDM--LWEQSNVF------IIKEGDYEYEYTMWERRK
>tr|A0A0L0P1H8|A0A0L0P1H8_9ASCO Uncharacterized protein OS=Candida auris GN=QG37_02791 PE=3 SV=1
---KISLIVALQPSMGIGAKGSLPWRL-KNEMKYFKDVTSKAK-DGHINAVVMGRKTWELIPERFRPLAGRLNVILSRKNDDL-SNGVYHFSSFDSVMKH
LEKRFKDMPLDKIFIIGGSQIYNLLILDSRVDNLLVTQVADKPQMDTFLDWDL--KWKRLEHY------LNEEGSYNYEYTMWEKAQ
>tr|A0A0N8AG60|A0A0N8AG60_9CRUS Uncharacterized protein OS=Daphnia magna PE=4 SV=1
---RLELMVAADTNLGIGKENKMAWHL-PTEFSYYRRMTTSPAPNGKVHASIFATKTWQSIPQEMKPWGNTICFILSRSMTAKGYSDVYIHSSIEDIIAH
IRLPEMRKRIDRVWMHGGAFGYQEALRSKHFYRIYHTKIHAEFQCDVFFPRYDENLKLVHDPDQGIQ---VD-HGISYQVHVYETTG
>tr|E9GAU4|E9GAU4_DAPPU Putative uncharacterized protein OS=Daphnia pulex GN=DAPPUDRAFT_240087 PE=4 SV=1
---RLELMVATDLKLGIGKGNKMAWHL-PTEFSYYRRMTTCANGSEKVHASIFATKTWQSIPPEMKPWGNTICFILSRSMTEDNYSDVYVHSSLEEIIAH
MRQTDMRKRIDRVWMHGGGFGYKEALRSKHFYRLYHTKIDAEFSCDVFFPRYDECLQIVDDPDQGIQ---LD-RGVSYQIHVYETTG
>tr|E9GAU3|E9GAU3_DAPPU Putative uncharacterized protein OS=Daphnia pulex GN=DAPPUDRAFT_301858 PE=3 SV=1
---RLELMVACDQNLGIGKDGTLPWSL-PSEFAYFLKMTQNYQGGGKVHASIFGRANWESIAKDNNPWKDTICYILSRSMSAH--ENVFVCSSFEDIINH
LNRPEIKERVDRVWVHGGVSVYTEALRSPYFYRLYRTTIEATYPADVFFPRVDESLTLVHDPDQGTQ---HE-NGVNFQVFVFQTTG
>tr|A0A0P6D7R0|A0A0P6D7R0_9CRUS Uncharacterized protein OS=Daphnia magna PE=4 SV=1
---RLELIVACDQALGIGKDGTLPWNL-PSEFAYFLRMTQNRQGGDKVHVSIFGRANWESIAKDNNPWKDTISFILSRSMTNQ--KDVYVCSSFQEIINH
LHKPEIKERVDRVWVHGGVSVYKEALGSPHFYRLYKTVIEATYPADVFFPRVDETLTLVHDPDQGVQ---RE-NDVDFQVFVFQSTG
>tr|A0A0F8WVT6|A0A0F8WVT6_9EURO Uncharacterized protein OS=Aspergillus ochraceoroseus GN=AOCH_003552 PE=3 SV=1
-------NAVQHTRLGIGLKGTLPWPRIKTDMSFFARVTARPPPIRPTNAIVMGRKTYDSVPGKLRPLGKRVSVVVTRDVSGQGQTDAFVAGGLEEALET
LDNQGARRNVGKVFVIGGAEIYGAALRLKK--RIVMTKVGGVFECDTFFPVDEELGWRKVSAWEEVS-EWIEEGEVRVQMVGYERVD
>tr|I8TWR4|I8TWR4_ASPO3 Dihydrofolate reductase OS=Aspergillus oryzae (strain 3.042) GN=Ao3042_04968 PE=3 SV=1
-----------KTLLGIGLNGTLPWPRIKADMSFFARVTTRPP--GTTNAMIMGRKTYDSVPKSLRPLGKRINVIVTRDVEGVPITDAIVSSGLEAALED
VEEF--KGGLGSVFVIGGAEIYATALGLGG--RIVMTNVKAVFECDTFFPIDEELGWRKVSAWEPVS-EWKDEGEVRIQMVGYERVN
>tr|A0A017S3S7|A0A017S3S7_9EURO Dihydrofolate reductase OS=Aspergillus ruber CBS 135680 GN=EURHEDRAFT_405812 PE=3 SV=1
---------NARPKLGIGQNGTLPWPRIKADMSFFARVTSRPPA-GSTNAVIMGRKTYESIPEKLRPLGKRINVVVTRDVEGNGTTDAIVSESLEGAMGD
LEGTGEESRLGNIYIIGGGEIYASALRSSA--RIVMTNVDKGYDCDTFFPVDDF-GWRTASPWEGVD-EWRDEGEVVIQMVGYERVD
>tr|A1CSV2|A1CSV2_ASPCL Dihydrofolate reductase, putative OS=Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) GN=ACL
---------TLPTRLGIGLNGTLPWPRIKADMSFFARATARPP--GTTNAIIMGRKTYDSLPRSLRPLAKRINVVVSRDGSGGGQTDAVVSSGLEEALET
LEGG-APGTLGHVFVIGGAEIYAAALRMAG--RIVMTNVGGAFECDTVFPVDEELEWRMVSDWEEVS-EWREEGDVRIQMISYECIL
>tr|A0A0J5SWB3|A0A0J5SWB3_ASPFM Dihydrofolate reductase OS=Aspergillus fumigatus Z5 GN=Y699_02923 PE=3 SV=1
---------NLPTRLGIGLHGTLPWPRIKADMAFFARATSRPP--GTTNAIIMGRKTYDSLPQNLRPLAKRINVVITRDSTGSAQTDALVSTGLEDALAS
LEGG-AEGRLGNVFVIGGGEIYASALRMSE--RIVMTNVGTEFECDTVFPVDEKLKWRMASEWEEVS-RWREEGDVRIQMVGYERIL
>tr|Q0C9A4|Q0C9A4_ASPTN Predicted protein OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) GN=ATEG_09730 PE=3 SV=1
---------QIPSRLGIGLNGTLPWPRIKADMSFFARVTSRPP--GTTNAIVMGRKTYDSLPKSLRPLGKRINVVVTRDASGSAGTDAIVCSGLEDALDT
LQRG-AQGTLGNVFVIGGAEIYAAALRMGG--RIVVTNVTASWDCDTFFPVDEELGWRRVEAWEPVS-EWREEGEVRIQMVGYERVV
>tr|C5FNI6|C5FNI6_ARTOC Dihydrofolate reductase OS=Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) GN=MCYG_04419 PE=3 SV=1
---------PSIRKLGIGKGGTLPWPKIKTDMRFFARVTTRPPPAPVINAVIMGRKTYDSIPARFRPLSKRLNVIITRDESGSEEPDVMVSNSLEAALST
LQSGAGKRRLGNIYIMGGSEIYASSLRLTPSLRIIMTHVVNGFDCDTCFPIDQQGGWKEVSSWEEVP-DWMWEGDCAVKTVGYERL-
>tr|G7XHR2|G7XHR2_ASPKW Dihydrofolate reductase OS=Aspergillus kawachii (strain NBRC 4308) GN=AKAW_04585 PE=3 SV=1
---ESSSSSSTPIRLGIGHSGTLPWPRIKTDMSFFARVTSRPP--GTTNAIIMGRKTYDSVPAPLRPLAKRISTIITRDVEGLPATDAIVCGGLDEALQE
LETG-DEGKLGKVFVIGGAEIYGAVLGAAK--RIVMTNVGEVFECDTFFPVDEELGWRRVTPWEEVT-RWIEEGDVRVQMVGYERQ-
>tr|A2QZD9|A2QZD9_ASPNC Aspergillus niger contig An12c0130, genomic contig OS=Aspergillus niger (strain CBS 513.88 / FGSC A1513) GN=An12g04590 PE=3 SV=
---------GSSIRLGIGHSGTLPWPRIKTDMSFFARVTSRPP--GTTNAIIMGRKTYDSVPAHLRPLAKRISTIITRDVDSLPATDAIVCGGLNDALQQ
LETG-EEGKLGKVFVIGGAEIYGAVLAAGK--RIVMTNVGEVFECDTFFPVDEELGWRKVSAWEVVT-EWIEEGDVRVQMRLCARAY
>tr|B6H1X6|B6H1X6_PENRW Pc13g03650 protein OS=Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) GN=Pc13g03650 PE=3 SV=1
---------EEITRLGIGLNGTLPWPRIKTDMSFFARVTSRPP--GTTNAIIMGRKTYDSVPGSLRPLAKRINVVITRDTSGSPMTDAIVTPSLGAALET
LDSA-AQGKLGKIFVIGGAEIYNATLNMGA--RVVMTNVSASFECDTFFPLDGL-GWRAVSPWEEVD-EWKTDGDVEVQMVGYEKST
>tr|S8ATI5|S8ATI5_PENO1 Uncharacterized protein OS=Penicillium oxalicum (strain 114-2 / CGMCC 5302) GN=PDE_04367 PE=3 SV=1
---------DASTRLGIGLKGTLPWPRIKTDMSFFARATSRAP--GTTNAIIMGRKTYYSVPKHLRPLAKRISVVVTRDTTGSPETAALVAPSLDAALSE
LDAG-KAGRLGKIYVIGGAEIYGLASRMEA-DRIVLTNVTEGYECDTFFPVEGL-GWRCVSSWEEVT-EWIRDGDVEVQMVGYERVD
>tr|A0A0F7TWR0|A0A0F7TWR0_9EURO Uncharacterized protein OS=Penicillium brasilianum GN=PMG11_09642 PE=3 SV=1
---------ENPTRLGIGLKGTLPWPRIKTDMSFFARATSRAP--GTTNAIIMGRKTYDSVPKNLRPLGKRISVIVTRDTTGAPITDALVTHSLDSALSE
LDAG-SSGRLGKIYVIGGAEIYGAALRMKMPGRIVMTKVAKEFECDTSFPVDGL-GWRTASAWETVT-EWIQDGEVEVQMVGYERLD
>tr|E4UQB5|E4UQB5_ARTGP Dihydrofolate reductase OS=Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) GN=MGYG_02210 PE=3 SV=1
---------PSIRKLGIGKGGTLPWPRIKTDMSFFARITTRPPASPAINAVIMGRKTYDSIPTRFRPLPKRLNVIITRDESGSDEPEMIVSSSLEDALST
LQRQAGKRQLGNIYIMGGSEIYASSLRLTADLRIVRTDVVDGFECDTCFPIDETDGWNQVSSWEDVS-DWIWEGDVAMKVLGYERL-
>tr|F2SKA9|F2SKA9_TRIRC Uncharacterized protein OS=Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) GN=TERG_03462 PE=3 SV=1
---------PGILKLGIGKEGTLPWPRIKKDMSFFARVTTRPPASPAINAVIMGRKTYDSIPAKFRPLSKRLNVIITRDESGSEEPEVIVSSSLEDALST
LQRQGGKKRLGNVYIMGGSEIYASSLRLTADLRIVMTDIVDGFECDTCFPLDGKGGWNKVPSWEAVS-DWTWEGDIAMKISGYEKL-
>tr|U1I1T6|U1I1T6_ENDPU Uncharacterized protein OS=Endocarpon pusillum (strain Z07020 / HMAS-L-300199) GN=EPUS_05804 PE=3 SV=1
---LYLIVAAVEPHMGIGYKGGLPWAQLKSDMGFFRRVTIRGGTIWRRNSVIMGRKTWESIPKKFRPLKGRVNVVVTRNALRMQEEEVIIVSSLQEGLSV
LSEPTNGDDEGKDFVIGGSEIYRAALDFPTSSRILQTQVGKGFDCDIFFPVDLQGRWREVDQW-------DGEGQCEIRVVGWEKTD
>tr|F4REP2|F4REP2_MELLP Putative uncharacterized protein OS=Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) GN=MELLADRAFT_104435 PE=3 SV=1
---SLNLIVCATVGNGIGKSGKLPWKL-KKDMKYFKFITSFIPSQNLKNVVIMGRKTWESIPRKFKPLENRINIIVSRKQTYEDSKDVYLTNSILNACEI
IQ----TLNIYKTYLIGGSELYNQIIKTPILANIYELKTDEGFECDTFLSDFKETNWKMSDNWLGIDEVNDDDGNNQIEFQLWEPNS
>tr|A0A0J6XZ81|A0A0J6XZ81_COCIT Dihydrofolate reductase OS=Coccidioides immitis RMSCC 2394 GN=CIRG_00837 PE=3 SV=1
---------PSISRLGIGNCGTLPWPRIKSDMSFFARITTRPPAPNALNAVIMGRKTYDSLPSRFRPLPKRLNVIITRDESGMETPDVLVSNGIGSALLA
LRDNGR-RSLGNVLVIGGAEIYASSLNLDPTLRIVMTDVSNGFECDTFFPIDNLDEWRRASAWEAVP-GWVWDQDIALRFLGYERST
>tr|A0A0F4YTK4|A0A0F4YTK4_TALEM Dihydrofolate reductase OS=Rasamsonia emersonii CBS 393.64 GN=T310_4804 PE=3 SV=1
---SPTNTATTSHLLGIGLNGTLPWPRIKSDMSFFARVTTRPPR-TTTNAIIMGRKTYESLPKNLRPLAKRINVVITRDTSGAPVTDALVSTSLEDALES
LQQK-QTTQVGNLFVIGGGEIYAAALRLPP--RIVMTKVEEYFQCDTFFPLNAHDGWREAPAWEPVS-DWKDEGDVSIKIVGYERVS
>tr|A0A093VL27|A0A093VL27_TALMA Dihydrofolate reductase OS=Talaromyces marneffei PM1 GN=GQ26_0150830 PE=3 SV=1
---------TTKPLLGIGLNGTLPWPRIKSDMNFFARVTSRPPLAEKLNAIIMGRKTYYSLPKSLRPLKDRLNVIISRDESGSDKRDALVAHSLEDALSQ
LFEK--RQDLGHVYVIGGGEIYKSSLELSSTTRILMTRVEEEYECDTFFPLTDEDGWRRAGAWESVG-DWIEEGEVAIKIEGYEKVK
>tr|V5FWS3|V5FWS3_BYSSN Uncharacterized protein OS=Byssochlamys spectabilis (strain No. 5 / NBRC 109023) GN=PVAR5_1667 PE=3 SV=1
---------KTITRLGIGLNGTLPWPRIKSDMSFFARVTARPP--GTTNAIVMGRKTYLSLPGHLRPLAKRINVVVSRNATGPPVTDAIVCSGLDSALET
LRKE-QQGKLGKVFVIGGGEIYASSLQLSH--RVVMTKVEQAFECDTFFPVDEMTGWREATAWETVS-DWKEDGDVAIQIVGYEKTL
>tr|B8M2L8|B8M2L8_TALSN Dihydrofolate reductase, putative OS=Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) GN=TSTA_0917
---------SKKPILGIGLNGTLPWPRIKSDMNFFARVTSRPPSKEKINAIIMGRKTYYSLPKGLRPLKDRLNVIISRDEHGTDKRDAFVAHSFDSALTQ
LFDR--RQDLGYVYVIGGGEIYKSSLELEVS-RILMTRIGEKYECDTFFPLTDEDGWRRVGVWESVK-DWTEEGEVAFKIEGYADIY
>tr|W2RVR1|W2RVR1_9EURO Uncharacterized protein OS=Cyphellophora europaea CBS 101466 GN=HMPREF1541_06079 PE=3 SV=1
---LYLIVATISPPLGIGARGTLPWPSLRADMNFFQRVTRDTRPTTTINAVIMGRKTYASIPPAYRPLSNRLNVILTRREPHDPPPPVIVASDLARVLRE
LWSRQAGWEVGNVFVIGGAELYREALQVRRTWRVLQTEVAEVEGLDTFFPGELGG--VKVEGWVGEG-ARDEKGEFEVRVSGWEM--
>tr|C0SJC0|C0SJC0_PARBP Uncharacterized protein OS=Paracoccidioides brasiliensis (strain Pb03) GN=PABG_07774 PE=3 SV=2
---NANAPSFTRRCLGIGHGGTLPWPSIKADMKFFSRVTTHAPPVTAVNAVIMGRRTYDSLPTRFRPLPGRVNVVVTRDGSGKETPDVLIANSLESAVTA
LYDHNSTRCLANIFIIGGSEIYASALNLNCKDRIVMTDIVNGFECDTFFPLDEDEEWRRVSCWVEVK-GWVQEGEVALRILGFERRG
>tr|R7UK12|R7UK12_CAPTE Uncharacterized protein OS=Capitella teleta GN=CAPTEDRAFT_228287 PE=3 SV=1
SSTRLNLVVAACTNKGIGVDGRLPWT-IRGDMAFFRKITSETSDPGKQNVVLMGRKTWESIPAKHRPLPNRINVVLSASLKEAPQGS-LLIRNFEDIFPL
MESSDLKDKINELFVIGGSSLYTMSFKSSHPVRVFLTTVLQEFHCDTFLPEMDDIKYQKI-EFAHEDIGKRTENGIPYQIEVYDK--
>tr|T1G9P0|T1G9P0_HELRO Uncharacterized protein OS=Helobdella robusta PE=3 SV=1
MQPKLQIIVALCKNRGIGLNNSIPWK-LPGDMTFFRKLTSETSILGSKNAILMGRKTWDSIPSNLKPLKNRLNVVISRTLECPDINGRHVSKSFEDAVEF
VA---SDKSIDKIFIIGGSSIYDLALASSTCYNVFITEISNDFQCDTFFPKFNQDAYKLI-KYPGHSTSVQLENGIGYQFTCHHK--
>tr|A0A081IAR5|A0A081IAR5_PLAVN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium vinckei vinckei GN=YYE_04219 PE=3 SV=1
----KASCFSNKTFKGLGNAGGLPWKCNSVDMKHFVSVTSYVNEDKLQNIVVMGKTSWESIPSKFKPLENRINIILSRTLKKENLSNVIIIKSVDELFPI
LK----CIKYYKCFIIGGASVYKEFLDRNLIKKIYFTRINNAYTCDLLFPDINEDVFKIT-----SISDVYSSNNTTLDFVIYSKT-
>tr|J9FQF0|J9FQF0_9SPIT Bifunctional dihydrofolate reductase-thymidylate synthase OS=Oxytricha trifallax GN=OXYTRI_22304 PE=3 SV=1
----FSV-IV--KNDGIGFKGDLPWPKIPKEMKHFVNVTTSKDPLDKVNAVIMGRKTWDSIPLKFRPLTKRMNVILTNQQNLEDT--IQVYNDFERALES
LSN---DPRVNEIFVIGGATVYDLAINKDFCKLIIKTRINKEFEVDTFMPKMDEE----------YISQTYSHQDVTFDYCFLGNK-
>tr|A0A078AJS8|A0A078AJS8_STYLE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Stylonychia lemnae GN=Contig16138.g17194 PE=3 SV=1
----FTV-IV--KNEGIGFKGDLPWPKIPKEMKHFVNVTTTKEPSDKINAVIMGRKTWDSIPLKFRPLQKRMNVILTNQTNLEDT--IQVFNDFQVALEN
LSM---NPRINEIFVIGGSTVYDLAINKEFCKLIIKTRINRDYECDTFMPKIDEE----------YISQTHQHDDITFDYCFIGNK-
>tr|T1YUQ7|T1YUQ7_HERMU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Herpetomonas muscarum PE=3 SV=1
----FSIVVA--ENHGIGDGKTIPW-RVPEDVAFFKEQTMKLRGTGKHNAVVMGRKTWESVPLKFQPMRDRLNVVMSSTATKEDLQLVVVRGGLQEALAV
LARPPYVSSVETVYCIGGAQVYDEALTSIDLHSVYLTRIHTVESCTRFFVFPPPPEWVQE-----STSGVLQSEALKYE--------
>tr|W6KJ57|W6KJ57_9TRYP Uncharacterized protein OS=Phytomonas sp. isolate EM1 GN=GSEM1_T00004620001 PE=3 SV=1
----FSMVVA--ENHGIGDGKTIPW-VVPEDMTFFKNQTTKLRGGGKVNAAIMGRKTWESISNEFRPLKGRLNVVLSSTSTKEDLLLVISEGGMAKALEV
LARPPYIHFVESVYCIGGAKVYNAALESVELHSVYATRIRLTKSCTRFFEFPPPSPWMLE-----STTGDLESGHTHYA--------
>tr|V7PE71|V7PE71_9APIC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium yoelii 17X GN=YYC_05462 PE=3 SV=1
----KSGSFNNKTFNGLGNAGMLPWKYNLVDMNYFSSVTSYVNENNLQNVVVMGKRSWDSIPPKFKPLQNRINIILSRTLKKEDIGTVMIIKSVDDLFPI
LK----AIKYYKCFIIGGSYVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFKIS-----SISDVYNSNNTTLDFIIYSKK-
>tr|A0A0B5L9B8|A0A0B5L9B8_9APIC Dihydrofolate reductase-thymidylate synthase OS=Plasmodium ovale curtisi GN=DHFR-TS PE=2 SV=1
----KSESYSNSTFRGIGNKGILPWKYNSVDISYFSSVTTYVNEKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKEDVEDIFIMKSMDEVLLL
LK----KLYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQIT-----SVSEVYSSNGTTLDFLIYSRK-
>tr|F0VQW6|F0VQW6_NEOCL Bifunctional dihydrofolate reductase-thymidylate synthase, related OS=Neospora caninum (strain Liverpool) GN=BN1204_065390 PE=3
----VSLIAA--PRRGIGVNNGLPWPHLATDFKHFSRVTKTTADVNRFNAVVMGRKTWESLPLKFRPLVDRLNIVVSSSLKEEDIQRVRVCDSLPAALRL
VDEE-YRESVDQIYVVGGAGLYEEALSLGVVSHLYITRVAR-FPCDVFFPAFPGDSYRPI-----FISKTYSDNGVPYDFVVLEKG-
>tr|A0A074T1R0|A0A074T1R0_HAMHA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Hammondia hammondi GN=HHA_249180 PE=3 SV=1
----VCLVVA--PKRGIGVNNGLPWPHLATDFKHFSCVTKTTSD-KRFNAVVMGRKTWESVPRKFRPLVDRLNIVVSSSLKEEDIQRVRVCASLPAALSL
LEEE-YKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAR-FPCDVFFPAFPGDTYRPI-----FISKTFSDNGVPYDVVVLEKR-
>tr|A0A059LGJ3|A0A059LGJ3_9CHLO Thymidylate synthase (Fragment) OS=Helicosporidium sp. ATCC 50920 GN=H632_c2296p0 PE=3 SV=1
----FQAVVA--RSWGIGKGTALPW-RLPGDMAYFKELTTRTHD--KCNAVIMGRKTWESLPPRFRPLPGRLNVVLSRSGGMELPPVARVCGGLEAALHW
LNEPETASFVEQVFVIGGGAVYEECLRSPQLQAVHLSRVSAAPECDVFMPSLPVATLKLW-----SASGPIVENGLRCEFLCYLRE-
>tr|A0A0K9NUT2|A0A0K9NUT2_ZOSMR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Zostera marina GN=ZOSMA_5G02610 PE=3 SV=1
----FQIVVA--GDMGIGKDGKLPW-KLPSDLKFFKEITMSTSD--KKNAVIMGRKTWESLPSHFRPLAGRLNVVLTRSQSFDIAENVVTSGSIRSALEL
LAASPYCLSIERVFVIGGGEVFRETLNDPGCDAIHVTDIEM-IGCDTFIPG--INVFRPW-----YSSFPSVENNIRYSFVSYVRV-
>tr|D8LBA4|D8LBA4_ECTSI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Ectocarpus siliculosus GN=Esi_0000_0340 PE=3 SV=1
----FVVIVA--GSLGIGKNGALPW-RLAADMAYFKRCTSTPTTTDKINAVIMGRKTWQSIPERFRPLAGRRNVVLSRNPAARDT--VLLAGSLTEALDL
LSPA-AASEVDKVFVIGGGSVYAEAVASELCEKVLLTSVTPPDDCDTHFPAL-DP----------KKGEAQEEKGVELSFDEYESV-
>tr|B7FQJ9|B7FQJ9_PHATC Predicted protein (Fragment) OS=Phaeodactylum tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_1690 PE=3 SV=1
-------VVA--SHRGIGYQGSLPW-RLPGDLRHFQAVTTQPPETGGTNAVIMGRKTWDSIPDRFRPLPGRINVVLTRHPERTLW--VLTATSLADAAAL
LAQ--PTRAVGHVFVIGGGQVYEQALREKFVNRVVYTEVANLSKFDAFFPPLPDA--PET-----GAWHTDGPSGITYRFLEYTRK-
>tr|A0A0G4J6H0|A0A0G4J6H0_PLABS Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodiophora brassicae GN=PBRA_002943 PE=3 SV=1
----FEVIAA--GSRGIGVRGGLPW-RLPADLRRFKRLTTG----SGHNAVIMGRNTWQSIPEKFRPLPGRINIVLTRDPSRIDS--VKVASSLTHGLSI
LRMLEDMEGIDRVFVIGGEKVYADALKMDECHVLHLTRVLDEESCDAFFPDVDWS----------DASDPMVENDTRFEFLTYVRR-
>tr|B5YMV7|B5YMV7_THAPS Possible thymidylate synthase (Fragment) OS=Thalassiosira pseudonana GN=TMS1 PE=3 SV=1
-------VVA--GSRGIGHQGKLPW-RLPGDMNHFKKVTTTPPSPGLTNAVIMGRKTWDSIPSKFRPLDGRVNVILSRKSAAGVE--VLVASSLEEAMQK
-LD--GRANHGSTFIIGGGEIYSQGIKSGLVKRVIYTNVKGLAKLDAFFPELTDSKKAKV-----AEEHEDAKSGLKYEFLEYIRR-
>tr|W7T463|W7T463_9STRA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Nannochloropsis gaditana GN=Naga_100065g11 PE=3 SV=1
----FTIVVA--KTFGIGKAGQLPW-NLPQDMEHFKRLTA----PDKINAVIMGRRTWQSIPEKFRPLRNRLNVVLSRNPGIREQ--VRVATSLKAALAL
LAHGNDASVVEKVFVIGGAAVYREAVESEACEAIEFTSIEEEADCDAHFPVI-PA----------SSTPVLSQNALRFRFQRYERL-
>tr|A0A0F9GEB0|A0A0F9GEB0_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_1837770 PE=3 SV=1
----INLIVA-RQDWGIAMNGELPW-KAPTDMRHFKQVTSETKNYNLRNAVVMGRKTYDTIG---RPLPNRMNYVVTRNPDLLQI--LCYVPSLKEALEQ
--ST-ANQDIERVFIIGGADMYMQSLTERWIDTTYLTLIDTEYPCDQFLSQKLVE----------STQEHVEKNGTRVVFQELR---
>tr|H3GWN7|H3GWN7_PHYRM Bifunctional dihydrofolate reductase-thymidylate synthase OS=Phytophthora ramorum PE=3 SV=1
----IRVVVA--STGGIGLSQQIPW-RLPSDMKRFRSLTTASP-SSAQHAVIMGRKTWESLPAKVRPMPKRYNVILTRDTSYRQR--VGVAASFHEALEL
VQQ--QEQEVDQVFVIGGGAVYGEALAYSGCHKVHLTRVKGQFECDAFFPSAQLA----------HESELMEENGVQFQFVEWERK-
>tr|A0A024TRZ0|A0A024TRZ0_9STRA Thymidylate synthase OS=Aphanomyces invadans GN=H310_10534 PE=3 SV=1
----ISVVVA--KTWGIGIDNTLPW-KLPSDMKRFREITTSTTDATKQNAVIMGRNTWESIPAKFRPLPGRLNVVLTRNSTLAAQ--VLAASSLDDAL--
AKL--SPTKIEHVFAIGGANVYSDALRHRACRKAYVTMVDGDFDCDAFFPSTLKQ----------EALGTQTENGIDFHFATFERK-
>tr|G4YSZ0|G4YSZ0_PHYSP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Phytophthora sojae (strain P6497) GN=PHYSODRAFT_555231 PE=3 SV=1
----VRVVVA--ATGGIGLRQQIPW-RLPSDMKHFKALTTAPSSSSAQHAVIMGRKTWESLPAKVRPMPQRYNVVLTRDASYRQS--VGVAASFREALEL
VQQ--QGDEVDQVFVIGGGAVYAEALAYVGCSKVHLTRVKGAFECDAFFPLEQLE----------SESELKEENGVQFQFVELERK-
>tr|A0A024GCE4|A0A024GCE4_9STRA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Albugo candida GN=BN9_051590 PE=3 SV=1
----ISIVVA--ECWGIGWRQSIPW-RLAKDLKHFRDLTTRTFSQTTRNAVIMGRKTWESLPSKYQPLPNRYNHILTRTSKYRIN--VGVSSSLADALDE
IEK--Q-VDISRIFIIGGQKVYEAALECATCDRIYLTIVKAKFECDTFFPSNLKS----------SESDEMEENGINFQFVELSRP-
>tr|G8DFJ0|G8DFJ0_9PHYC Thymidylate synthase OS=Emiliania huxleyi virus 202 GN=EXVG_00185 PE=3 SV=1
----VCIVVASDGRIAIGVNNRIPW-NSKADMHNFRQLTTSTKLPICENVVIMGAKTWQSIG---RRLPNRYNIVISRNKDARKV--VGISSSIESAIDQ
LKT---VSDVETIYIIGGSYIYKNALDLGIVSKIHMTFVSDADNSDTFFPLTVDE---KS-----RSSYITKENHITCSY-------
>tr|G3GPM8|G3GPM8_9PHYC Thymidylate synthase OS=Emiliania huxleyi virus 203 GN=ELVG_00358 PE=3 SV=1
----VCIVVASDGRIAIGINNKIPW-NSKADMHNFRQLTASTSMPICENVVIMGAKTWQSMG---KRLPNRYNIVISRNKDARRV--VGISSSIELAISE
LKT---VSDIETIYVIGGSYIYKDVIDLKIVDKIHMTFVSNQDTCDTFFPLTVND---KS-----KTSYVTKEAHLTCSY-------
>tr|F0W9B4|F0W9B4_9STRA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Albugo laibachii Nc14 GN=AlNc14C39G3381 PE=3 SV=1
----ISIVVA--DCWGIGWRQSIPW-KLAKDLKHFRDLTTRTFSQNMRNAVIMGRKTWESLPPSYQPLPNRYNHILTRTTNYRID--VGISSSLADALEE
IER--Q-EDIGRVFIIGGQKVYEAALECTSCDRIYLTTVKATYQCDTFFPSNLKD----------SESDEMEENEIRFHFRELSRP-
>tr|M4BX13|M4BX13_HYAAE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Hyaloperonospora arabidopsidis (strain Emoy2) PE=3 SV=1
----LSVIVA--TNGGIGLQQKIPW-HLPTDMKHFRALTTSRCDLKQQHAVIMGRKTWESLPTAVRPLPKRYNVILTRDLSYRTR--VGVAASFSEALKL
VEL--QGEKVDQVFVIGGSAVYAESLAHSECKKVFLTRVKGEFKCDAFFPLELLK----------NESEIKKENDVEFQFVEWARN-
>tr|A0A0L0D3U4|A0A0L0D3U4_THETB Bifunctional dihydrofolate reductase-thymidylate synthase 2/DHFR-TS OS=Thecamonas trahens ATCC 50062 GN=AMSG_03204 PE=3 SV=1
----YGLVVA--DDGVIGIDGGLPW-TLRGDMAHFVSVTKGLTPDEAARVVIMGRKTWNSIPQRLRPLKDRVNIVVSRTMLE---EGVHLARSLDDALLV
ASL--V-PRVGLVSVLGGFQLFAEAMQDPRCTWVELTEVHTALAAQGFFAE--------------VSRSERHESGIEFEYVRYERI-
>tr|D8LWN8|D8LWN8_BLAHO Thymidylate synthase OS=Blastocystis hominis GN=GSBLH_T00000592001 PE=3 SV=1
-----FSIVA--TKRGIGLNGGLPW-RIKQDMKFFVDLTTTTTDSEKQNAVIIGKNTYFSFPEKFRPLKNRINFIISHDKELREK--VYICSSVDEALIL
MQEEELKRKIENIFVIGGGQIYKKAINLPECEKLYLTEVDADISCDTFFPEIPLA--KKT-----KESETFEENNFKFRFAEYTRL-
>tr|R1BUZ9|R1BUZ9_EMIHU Uncharacterized protein OS=Emiliania huxleyi GN=EMIHUDRAFT_451981 PE=3 SV=1
----FSVVVA--QSRGIGVSNQLPW-RLRGDMQYFKQLTRSTRD--KQNAVIMGRKTWESIPEKMRPLGDRLNVVISANPAARELDKVLLATSLGDALQQ
LCEGDYAASVESVFVIGGSSVYAEAVDLPQCERVYYTEVSKHFGCDTHFPPL--PTWRQA-----SASAPRDENGLSYRFLAFESR-
>tr|A0A0M0JXL9|A0A0M0JXL9_9EUKA Dihydrofolate reductase-thymidylate synthase OS=Chrysochromulina sp. CCMP291 GN=Ctob_005352 PE=3 SV=1
----FAVVVA--QTRGIGQAGALPW-RLRADMAYFKQLTRSTRD--KRNAVIMGRKTWQSIPTKFRPLDDRVNVVLSRTADT---KGVLCASSLPQALEL
LGEDEAGATIENVFVIGGASVYEEAIAMPACARIHLTEIEQVFECDTFFPP--LAAYV-----------------------------
>tr|M2Y9L6|M2Y9L6_GALSU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Galdieria sulphuraria GN=Gasu_03410 PE=3 SV=1
----LRIVVA--NARGIGLLGKMPW-KLKKDLQFFKELTLG-------NPVIMGRKTWESLPTASKPLKKRLNVVLTSNPTLFQK--CLACNSLESALNM
LR----LRSFPVAYIIGGRQVFEEALVNPACSRVYLTRIYEDFACDTFFPCLP------------SNSEIFEENGIKFEFLEYRRD-
>tr|D8SA97|D8SA97_SELML Bifunctional dihydrofolate reductase-thymidylate synthase OS=Selaginella moellendorffii GN=SELMODRAFT_233517 PE=3 SV=1
----FQVVVA--TDLGIGKEGKLPW-SVPSDMAFFKRITSEAAD--KKNAVVMGRRTWESIPAKFRPLPGRVNVVLSRAGL---EDKAIVCSSLDSALGI
LAAPPFDSSVEAVFVIGGGEVFREAMVSPLCTAIHLTEIQT-FECDTFMPA--LDCFRLW-----YASSPATVNNVRHSFHTYVRN-
>tr|D0N806|D0N806_PHYIT Bifunctional dihydrofolate reductase-thymidylate synthase OS=Phytophthora infestans (strain T30-4) GN=PITG_06749 PE=3 SV=1
----IRVVVA--TTGGIGLRQHIPW-RLPSDMKHFRALTTASPDSSVQHAVIMGRKTWESLPAKVRPMPKRYNVVLTRDSSYRNK--VGVAASFREALKL
VQE--QGDKVDQVFVIGGGAVYAEALSYPSCTKVHLTRVKGQFECDAFFPLEQLE----------EESEVKEENGVQFHFVEWERK-
>tr|A0A067CMI2|A0A067CMI2_SAPPC Bifunctional dihydrofolate reductase-thymidylate synthase 2 OS=Saprolegnia parasitica (strain CBS 223.65) GN=SPRG_06761 PE=3 SV
----LSMIVA--ATNGIGIKGQLPW-RLAGDLKRFRELTTSTADATKQNAVVMGRKTWESLPLKHRPLPGRVNVVLSRNPAVRAA--VLAAGNLDEAL--
GAL----TGVEHVFIIGGQSLYEEAAQHPRCTRAYLTLVDGEYECDAFFPKSLAS----------SVSPVQIEKDISFQYIQLDRK-
>tr|A0A0P1A6G0|A0A0P1A6G0_9STRA Thymidylate synthase OS=Plasmopara halstedii PE=4 SV=1
----IRVVVA--STGGIGFLGKIPW-HLPSDLKFFRTLTTASLDSSIQHAVIMGRKTWESLPDKVRPMPKRYNVILTRDTSYRQK--VGIAATFQDALKL
VQQ--QGDKVDQVFVVGGEALYAEALSYSGCSKVYFTRVKGQMECDAFFPLEQLK----------KESEIMEENGMQFQFVEWVRK-
>tr|W2GVH2|W2GVH2_PHYPR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Phytophthora parasitica GN=L915_08505 PE=3 SV=1
----IRVVVA--TTGGIGLRQQIPW-HLPSDMKHFRALTTASSDSPAQHAVIMGRKTWESLPAKVRPMPKRYNVVLTRDSSYRQT--VGVATSFREALEL
VQQ--QGDRVDQVFVIGGGAVYTEAMSYPGCAKVHFTRVKGQFECDAFFPLEQLK----------EESDIREENGVQFQFIEWERK-
>tr|A0A0Q3HES9|A0A0Q3HES9_BRADI Uncharacterized protein OS=Brachypodium distachyon GN=BRADI_4g07810 PE=4 SV=1
----YQVVVA--HEMGIGKDGALPW-KLPSDLNFFKELTMATSD--KKNAVIMGRKTWESIPAKFRPLPGRLNVILTRSGSFDFAENVVICGSLDSSLEL
LASTPYSLTIEKAFLIGGGQVLRDSLNAPACEAIHLTDIES-IECDTYIPP--IDVFHPW-----YSSFPVVENNIRHSFVTFVRV-
>tr|M0S7X1|M0S7X1_MUSAM Uncharacterized protein OS=Musa acuminata subsp. malaccensis PE=4 SV=1
----YQVVVA--RDMGIGKDGNLPW-KLPSDLKFFKEVTMTTSD--KRNAVIMGRKTWESIPPRNRPLPGRLNVVLTRSGSFDIAENILMCGSLNSALEL
LAATPYCLSIERVFVIGGGQVLREALNAPGCEAIHLTDIET-FQCDTFIPP--VDVFRPW-----YSSFPLLENSIRYSFVTYVRI-
>tr|A0A0J8BG76|A0A0J8BG76_BETVU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Beta vulgaris subsp. vulgaris GN=BVRB_9g217140 PE=3 SV=1
----YQVVVA--KEMGIGKDGKLPW-NLPFDLKFFKDVTLQTSN--RMNAVIMGRKTWESIPLKFRPLPGRLNIVLTRSRDFDAGDKVKGCDSMDSALRL
LAMCPYDLSIEKVFVIGGGQILREALNAPDCDAIHMTEIET-IECDTFIPP--VDLFQPW-----YSSFPYVENDIRYSFVTYARV-
>tr|Q4DLS1|Q4DLS1_TRYCC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Trypanosoma cruzi (strain CL Brener) GN=Tc00.1047053509153.90 PE=3
----FSLVVA--EHGGIGDGRSIPW-NVPEDMKFFRDLTTKLRGPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLSIVAVNGGLEQALRL
LASPNYTPSIETVYCIGGGSVYAEALRPVHLQAIYRTTIRASSSCSVFFRVPESGEWQRE-----TISEELTSNETKYY--------
>tr|T1YUI7|T1YUI7_9TRYP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Angomonas desouzai PE=3 SV=1
----FTIVVA--EHHGIGDGKQLLW-RIPEDMQFFKETTLKLRGPSKRNAVVMGRNTWESIPVHFRPLKDRLNVVLSRTQTKEQLLVVINEGGLKAALHL
LAQPPYIYNVETVHCIGGSQVYQEAMESVELSTVYLTRVYASPACTCFFPFAIEERFVVE-----SSQGKKKSDGHEYE--------
>tr|S9VC74|S9VC74_9TRYP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Angomonas deanei GN=AGDE_03361 PE=3 SV=1
----FAVVVA--LAGGIGDGNQLLW-KVPEDMQFFKETTLKLRGPTKQNAVVMGRHTWGSIPIPFRPLKDRLNVVLSRTKTKDDLLLVIQEGGLLGALQL
LARPPYIYSVETVHCIGGSQVYLEALRSVELHTIYFTRIHSTDACTCFFPFTVTGHYVVE-----SNQGKKTSGALGYE--------
>tr|G0TZ26|G0TZ26_TRYVY Bifunctional dihydrofolate reductase-thymidylate synthase OS=Trypanosoma vivax (strain Y486) GN=TVY486_0705520 PE=3 SV=1
----FSVIVA--ENGGIGDGTSIPW-NLPEDMQFFKKTTTRLRGPQKRNAVVMGRKTWESLPAKFRPLSNRLNVVLSRAATKEQLDVLVVNGGLSDALKL
LVQPPYTSSVETVYCIGGGSIYAEAIQQVDLQAIYRTLVRTRESCNVFFHLPSKGEWVRE-----SITEELTSSGTKYQ--------
>tr|Q582G3|Q582G3_TRYB2 Bifunctional dihydrofolate reductase-thymidylate synthase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) GN=Tb927.7.5480
----FSVVVA--EKGGIGDGGTIPW-EIPEDMQYFRRVTTNLRGPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLDVVAVNGGLEDALRM
LVSKEHTSSIETVFCIGGGTIYKQALCAVNLQAIHRTVVRPANSCSVFFDIPAAGELVRE-----SITDERVSGGKKYQ--------
>tr|A0A0M9G6W3|A0A0M9G6W3_9TRYP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Leptomonas pyrrhocoris GN=ABB37_01952 PE=3 SV=1
----FSIVVA--QQHGIGDGETIPW-RVPEDVAFFKDQTTLLRNEKKRNAVVMGRKTWESVPLKFRPLKGRLNVVLSSQATVADLNVLVVNGGLKEVLHT
LARPPYCSAVETVYCIGGARVYSEAMQSVEMHEVFLTRVHTTPTCNRFFPFPPSPQWDVE-----STTGVRKSAGLEYE--------
>sp|Q23695|DRTS_CRIFA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Crithidia fasciculata PE=3 SV=1
----FSIVVA--QQHGIGDGETIPW-TVPETLAFFKDQTTLLRNEKKRNAVVMGRKTWE-VPLKFRPLKGRLNVVLSCRRPVDDLD-VVINGGLKEALHL
LARPPYCSSIETAYCIGGARVYTEAMQSVELKEVYLTRVH-TPTCNRFYEFVRRRAVDLE-----STSGVKVSAHLSYE--------
>tr|T1YT97|T1YT97_9TRYP Dihydrofolate reductase OS=Crithidia acanthocephali PE=3 SV=1
----FSIVVA--QQHGIGDGETIPW-RVPEDVAFFKEQTSLLRTDKKRNAVVMGRKTWESVPLKFRPLKGRLNVVLSSQATAEELSLLVVNGGLKEALRH
LAVPPYCSSIETVYCIGGARVYTEAMESVELHEVFLTRIETTPSCTRFYPFPPPPQWHLE-----STSGVQKSAGLSYE--------
>tr|A0A0N1IJX9|A0A0N1IJX9_LEPSE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Leptomonas seymouri GN=ABL78_5323 PE=3 SV=1
----FSVIVA--QKHGIGDGETIPW-RVPEDVAFFRDQTTLLRNAKRRNAVVMGRKTWESVPLKFRPMKGRLNVVLSSKAAAGDLNLLVINGGLKEALHL
LARPPYCSSIESVYCIGGARVYDEAMQSVELHEVFLTRVFATPSCNRFFVFPPPPQWDLE-----YTAGVKKSTGLEYE--------
>tr|A0A0G4HTD0|A0A0G4HTD0_9ALVE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Chromera velia CCMP2878 GN=Cvel_8423 PE=3 SV=1
----VNVVVA--ATFGIGVKGRLPW-ELPSDMNFFRRLTSEVTSEEKQNAVVMGRKTWESIPSKYKPLKNRLNVVISSSLTSSDV--VKLVKSLREALSL
-LQGDLRDRTEAVFIIGGASVYKAAFESGVVSRVFWTRIGVDIECDTFVPKFWSEKFRLV-----SLSESRAENGVPFDFAVLENE-
>tr|C5LQI2|C5LQI2_PERM5 Bifunctional dihydrofolate reductase-thymidylate synthase OS=Perkinsus marinus (strain ATCC 50983 / TXsc) GN=Pmar_PMAR025126 PE
----QLSVIV--CKWGIGKDGQLPWKSLPEDMKRFKKITTGGHCDNVKNVCIMGRKTWESIPERFRPLRDRINVVISSTTSPTDY--VRICPSLLDSLAS
LQQ--GEVEIGEIFVIGGASLITEAMQLPQCRTLYTTRVGTDWECDVFMEKIDEK----------AVSRTFRHSDIPYDFVDYKRR-
>tr|T1YUK5|T1YUK5_STROO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Strigomonas oncopelti PE=3 SV=1
----FQIVVA--QHEGIGDGETIPW-HVPEDVQFFKDKTMKLRGRTKMNAVVMGRKTWESVPVRFRPLKDRLSVVLTRSQTKEELLVVVAEGGLAAALAL
LARPPYITSVETVFCIGGAQVYTEAMAAIELTTIYLTKVTAAARCSRFFPFDPAARWELE-----HSSGPLVSGGLTYE--------
>tr|W6LD00|W6LD00_9TRYP Uncharacterized protein OS=Phytomonas sp. isolate Hart1 GN=GSHART1_T00001610001 PE=3 SV=1
----FGLVVA--AKHGIGDGLAIPW-AVPEDMAFFKTQTSKLRGGGKINAVIMGRKTWQSIPGNFLPLQDRLNVVLSSTTSREELLLMVIPGGMTEALEM
LARPPYIDRVESVYCIGGAKVYADAVQAVDLHAVYATRIALSPSCTRFFEFPTPQTWALE-----STTGDMVSDLTHYA--------
>tr|S9UVF7|S9UVF7_9TRYP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Strigomonas culicis GN=STCU_00393 PE=3 SV=1
----FQIVVA--QHDGIGDGETIPW-HIPEDVLFFKEKTMKLRGPTKMNAVVMGRKTWTSVPAKFRPLKDRLSVVLSQSQTKEQLLVAVSEGGLAAALAL
LARPPYIHSVETVFCIGGAQVYDEAMAAVDLATVYLTKVTASAKCSRFFRFNPAQRWELE-----HTTGPLVSGQLTYE--------
>tr|R0HKJ0|R0HKJ0_9BRAS Uncharacterized protein (Fragment) OS=Capsella rubella GN=CARUB_v10013341mg PE=3 SV=1
----YQVVVA--KEMGIGKDGNLPW-NLPTDLKFFKDVTLTTSD--KKNAVVMGRKTWESIPIKHRPLSGRLNVVLTRSGGFDIAENVVTCSSVDSALDL
LALPPYCLSIERVFVIGGGDILREALNRPSCDAIHLTEIDT-IECDTFIPA--IDVYQPW-----YSSFPITENGLRFCFTTFVRV-
>tr|M4D9B9|M4D9B9_BRARP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Brassica rapa subsp. pekinensis GN=Bra013079 PE=3 SV=1
----YQVVVA--KQMGIGKDGKLPW-NLPTDLKFFKDITQTTSD--KKNAVVMGRKTWEAIPTKHRPLPGRLNVVLTRSGGFDIAENVVTCSSVDSALHL
LAAPPYCLSIERVFVIGGGDILREALNMPSCDAIHLTEIDT-IECDTFIPE--VDVYQPW-----CSSVPVTENGLRFRFTSFVRV-
>tr|A0A023AYK9|A0A023AYK9_GRENI Dihydrofolate reductase-thymidylate synthase OS=Gregarina niphandrodes GN=GNI_160380 PE=3 SV=1
----VASIF-STLTGGIGNKGRLPW-RLKEDLESFERITKTVGKNGMPNGVIMGRKTWDSIPT--SPLKDRINCVVTSHPDDLLGYGADLRGSLLLRLPF
LQEGNRLRNCSTIYITGGAGLYNMSHEAQIADYIIWTRVCGEIATDVHVDLALLE----------GVSKTKGSGRYTFDVAVLRKK-
>tr|A8JD96|A8JD96_CHLRE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Chlamydomonas reinhardtii GN=CHLREDRAFT_139742 PE=3 SV=1
----FQLVIA--PSLGIGKNGKLPW-QLPGDMAYFKELTSRTRD--HTNAVIMGRKTWESIPAKFRPLKGRLNIVLSRSFAD-------DADLLESALSL
LEHKELKGGVEGVFIIGGGQVYAEALAHPNCTAVHLTQVEK-YECDTFLPA--LDVWGVW-----SSSEPVTENNTRYSFVCYTRR-
>tr|F6H1I8|F6H1I8_VITVI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Vitis vinifera GN=VIT_18s0001g12940 PE=3 SV=1
--------------MGIGKDGKLPW-NLPSDLKFFKELTMTTSD--KKNAVVMGRKTWESIPLNYRPLPGRLNVVLTRSGSFDNAENVVICGSMPSALKL
LAESPYCLSIDKVFVIGGGQILREALNAPGCDAIHITKIET-IECDTFIPT--IDVFHPW-----YSSVPLLENNILYSFVTYVRV-
>tr|W9SEL2|W9SEL2_9ROSA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Morus notabilis GN=L484_021927 PE=4 SV=1
----YQVVVA--------------------RKSAMEELTATTLD--KKNAVVMGRKTWESIPLQFRPLPARLNVVLSRSGKVGDSENVVICESISSALES
LAQPPYSQSIEKVFVIGGGQVLREALNAPRCDAIHITEIET-IDCDTFIPS--IDSFQPW-----YSSQPFVENNVRFSFATYVRV-
>tr|K8ECA8|K8ECA8_9CHLO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Bathycoccus prasinos GN=Bathy03g03500 PE=3 SV=1
----FQVVVA--ELGGIGKNQTLPW-KLSKEMKHFKSLTADVSK--TQNAVIMGRKTWESIPEKFRPLPGRLNVVLSASGRVYEKEGVLARASIEEALET
LSTGEYKDIIEKVFVIGGAKVYEEALKSEQCEAVHLTEVKPPFACDAFIPL-PLDKFRLY-----SSSKLVKDGECSYTTLTYVAQ-
>tr|I0YVC8|I0YVC8_9CHLO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Coccomyxa subellipsoidea C-169 GN=COCSUDRAFT_37014 PE=3 SV=1
----FQIVVA--RKLGIGKGGTMPW-KLPGDMAYFKELTTRTAD--NQNAVVMGRKTWESIPPKFRPLPGRVNVVLSRGSVGS----------LEAAMAL
LGETSFKERIETVFVIGGGKVYEEALPSPLCSAVHFTAIEA-IECDTFFPE--MSKWRLW-----SESAPRRNGDMRYSFQCYVPA-
>tr|D8UB22|D8UB22_VOLCA Putative uncharacterized protein OS=Volvox carteri GN=VOLCADRAFT_66296 PE=3 SV=1
----FQLVVA--PSLGIGKNGTLPW-KLPGDMAYFRELTSRTRE--CQNVAIMGRKTWESIPNKFRPLKGRINIIARRNGAQFG-PDVLGCSSLGAALEL
LEDEKLKRDVDFVFVIGGAQVYAEALRHPSCTAVHLTKVEK-FDCDAHLPP--LDVFGVW-----SASEPFQENDTRYSFVCYTRR-
>tr|A0A090M2Y4|A0A090M2Y4_OSTTA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Ostreococcus tauri GN=OT_ostta01g05920 PE=3 SV=1
----FQVVVA--VDGGIGKDNGLPW-KLTKDMGHFKKLTSETRD--AVNAVVMGRKTWESIPAKFRPLPGRLNVVLSRSGVLAEAEGVLVRKTIDDALSA
ISSS-E-KRVEKTFVIGGAQIYEEALKSERCEAVHLTEVE--FECDVFIPK--IDKFKLY-----GQSKPITENGARYQFLTYVTK-
>tr|A4RXM1|A4RXM1_OSTLU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Ostreococcus lucimarinus (strain CCE9901) GN=OSTLU_49676 PE=3 SV=1
----FQVVVA--REGGIGRENALPW-RLAGDMGYFKKITSETRD--AMNAVVMGRKTWESIPGKFRPLPGRLNIVLSRSGGLAEAEGVLVRKSIDDALSA
ISSS-E-KRIEKTFVIGGAQIYEEALQSEKCEAVHLTEVE--FECDAFIPK--IDKFKLY-----GQSKPMIEKGTRFQFLTYVTA-
>tr|E1ZCI9|E1ZCI9_CHLVA Putative uncharacterized protein OS=Chlorella variabilis GN=CHLNCDRAFT_30873 PE=3 SV=1
----IQIVVA--KQWGIGKGGSLPW-SLPGDMKYFRELTSRTAD--KQNVVIMGRKTWESIPAKFRPLAGRINVVLTRGAVAGDEEGVHISSSLDSALEM
LSGPEFDSRVESVFVIGGGQVYKECMESPLLSAIHLTLVEGEANCDTFMPP--VDRFRLW-----SASAPRSVGGTRYSFLCYTRA-
>tr|A0A061R0Z3|A0A061R0Z3_9CHLO Dihydrofolate reductase / thymidylate synthase OS=Tetraselmis sp. GSL018 GN=DHFR-TS PE=3 SV=1
----FQIVVA--RQYGIGKSGTLPW-RLPGDLKYFRELTSRTEN--KKNAVIMGRNTWESIPSKFRPLPGRLNVVLSRSASDSGFAEVVFQRSLDSALEY
LASAKVSEELEEVFVIGGGQVYREALLSEACTAIHFTQIEDDIDCDTFFPP--IDCFRYW-----SGSYPQREGSLRYRFLCYTKL-
>tr|R7Q5X1|R7Q5X1_CHOCR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Chondrus crispus GN=CHC_T00010030001 PE=3 SV=1
----TSLILA--PSRGIGLAGALPWPRLPSDLRNFKTLTLG-------AAVLMGAATYESLPEAVRPLPGRLNVVLSRRSRPELL--VLIAGSFDAAEEL
-LK---SKGVENCFVIGGESVYREAIKIPAWQRVYYTEIDKEFKADRFFPVDLAKAFSLL-----SVSGDIEESGVRYRIKEYVRV-
>tr|C1E6F7|C1E6F7_MICSR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Micromonas sp. (strain RCC299 / NOUM17) GN=DHFR-TS PE=3 SV=1
----FQVVVA--GEMGIGYQGGLPW-NLPKDMAYFKAVTSQVNE--TKNAVVMGRKTWESIPAKFRPLPGRVNVVLSRGHTLVEAEGVFLRPSLEAALEL
LSAPEHEAGVEKVFVIGGAQVYAEAMASPHCQALHLTEVTPPYKCDAFLPQ--IDKFKLY-----ASAKPLREDGATIQFLTYFGV-
>tr|C1MMA6|C1MMA6_MICPC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Micromonas pusilla (strain CCMP1545) GN=DHFR-TS PE=3 SV=1
----FQVVVA--GDMGIGLDGALPW-RLPKDMAYFKSVTATVAE--KRNAVIMGRKTWESIPAKFRPLPGRLNVVLSKSGALVESPSVLLQPSLEAALAT
LGAGEHAENVEKIFVVGGAQVYAEAMASPACQAVHITEVTPPFKCDTHMPP--VDKFKLY-----ASAPPVNEEGAKIQFLSYVAK-
>tr|U3M4M6|U3M4M6_PLAGO Dihydrofolate reductase-thymidylate synthase (Fragment) OS=Plasmodium gonderi GN=dhfr-ts PE=3 SV=1
----KNEVFSDRTFKGIGNNGTLPWKCNTIDMKYFSSVTTYVDEMQLQNIVVMGRSSWDSIPKQFKPLPNRINVVLSKTLKYEHVEKIYIISSIDELLLL
LR----KLNYYKCFIIGGAQVYKECLNRNIIKQIYFTRINNSYECNVLFPDIDREKFRVT-----SVSEVYNCKGTTLDFVIYSKV-
>tr|Q8MXB7|Q8MXB7_LEITR Dihydrofolate reductase-thymidylate synthase OS=Leishmania tropica GN=dhfr-ts PE=3 SV=1
----FSIVVA--KQHGIGDGESIPW-RVPEDMAFFKDQTTLLRNEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELDVVVVNGGLAEALRL
LARPPYCSSIETAYCVGGAQVYADAMLSVELQEVYLTRIYTTPACTRFFPFPPENAWDLA-----SSQGRRKSEGLEFE--------
>tr|A0A088S2I0|A0A088S2I0_9TRYP Dihydrofolate reductase-thymidylate synthase OS=Leishmania panamensis GN=DHFR-TS PE=3 SV=1
----FSIIVA--EQHGIGDGKTIPW-QVPEDMAFFKDQTTLLRNEKKRNAVVMGRQTWESVPLKYRPLKGRLNVVLSSKATVDELDLVVVNGGLAEALHL
LARPPHCSSIETAYCVGGAQVYSDAMTAVELQEVYLTRIYATPECTRFYPFPPTNAWDLA-----WTQGRQRSGGVEYE--------
>tr|Q4U9G5|Q4U9G5_THEAN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Theileria annulata GN=TA08775 PE=3 SV=1
----FVKILV--PENGIGIKNGLPWPHIKRDFLFMFRATTYVDPPGAENVIIIGRNTYDSLPESVFPLKNRINIVISRNLTE--V--GLVFSSIPSAIRH
VTE---NLNYYKIFIMGGSHVYREVLNAKIVDKMYVTRVNKNYECEVFFPKIPDD----------GISKTFSSEDTSYDFVLYERK-
>tr|Q7Z0Z9|Q7Z0Z9_BABBO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Babesia bovis PE=3 SV=1
----GLTIYV--LNRVIGHQNQIPWPHIIHDFRFLRNGTTYIPPPNIQNVVIFGRKTYESIPKASLPLKNRINVIISRTVKE--V--CLVYEDLSTAIRD
LRA---NVPHNKIFILGGSYLYKEVLDNGLCDKIYLTRINKEYPGDTFFPDIPDT----------AISPTFSTDFVSYDFVIYERK-
>tr|A0A061D7M8|A0A061D7M8_BABBI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Babesia bigemina GN=BBBOND_0200560 PE=3 SV=1
----GLEIFV--LNGTIGCKNDIPWPHIRQDFRFLCRGTTYVEPPSLQNVVIFGRRTYESIPQTSLPLKNRINVVLSRTVKD--I--VLVYSSLCEAIRS
LRA---SVPHNKIFILGGADLYREVLENDLCDKIYLTRLNKEYEGDRFFPPIPSS----------GISRTFSTDFVTYDFVTYEKV-
>tr|L0B0P3|L0B0P3_BABEQ Bifunctional dihydrofolate reductase-thymidylate synthase OS=Babesia equi strain WA GN=BEWA_008170 PE=3 SV=1
----NVQIVV--PKNGIGLKNNLPWPHIKKDFLFLSRITNYIEHQNLQNVVIFGRNTYFSLPPSAAPLKNRINVVISKTVRE--I--VLVYETLPLALKK
IQE---EVKYNKIFILGGSYLYKEAIDSGLCEKIYLTRIAKNYEADVFFPQLPDS----------GISKTFGTDDTTFDFVIYEKK-
>tr|J4C4E3|J4C4E3_THEOR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Theileria orientalis strain Shintoku GN=TOT_040000412 PE=3 SV=1
----PIKILA--PDNGIGNTNGLPWPHIKRDFLYMFRLTTYVDPSEIQNVVVIGRKTYDSLPPNTFPFKNRISVVISRTLSE--V--GFVFDSVPKALMY
IKD---NLNYYKIFILGGSFIYNEVINMPVLDTLYITRVNKKYPCDVFFPKIPED----------GISKTFTNGDTTYDFVTYERK-
>tr|B5U9U8|B5U9U8_BABGI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Babesia gibsoni GN=Bgdhfr-ts PE=2 SV=1
----GLQIIV--LNRVIGKNNEIPWPHIRQDFRFLYWVTTFIEPPELKNVVIFGRKTYESIPQNVLPLKGRINVLISRSIKE--M--VLTFSSLDAAIKE
LRA---SVPHNKIFILGGSEIYRLVLENDLCDKIYQTRINKDYEGDRFFPEIPDT----------GISKTFGTDFVTYDFVTYEKK-
>tr|Q4N262|Q4N262_THEPA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Theileria parva GN=TP04_0504 PE=3 SV=1
----FVKLLV--PENGIGISNGLPWPHIKRDFLFMFRATTYVDPPGAQNVIIIGRKTYDSLPEGTFPLKNRINVVISRNLTE--V--GLVFPSMPAAIRH
VTE---HLNYYKIFIMGGSYVYRDALDARIVDKMYVTRVNKNYKCEVFFPKIPDD----------GISKTFSSEDTTYDFVTYERK-
>tr|A0A0G4GKP0|A0A0G4GKP0_9ALVE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Vitrella brassicaformis CCMP3155 GN=Vbra_18155 PE=3 SV=1
----ISLIVA--PSRGIGKNGSLPW-HLPPDLAYFKRLTTTTSTEVGQNAVVMGRNTWMSLPQRVRPLPGRLNVVVSSTLQAGN-AGVEVVSSLDAALDL
IESA-YTTKVDQVFVIGGAALYASALDSSRVGTIYLTRIGR-FECDTHMPE--IDRFRLV-----SLSRTHAYQDIPFDHLVYEAV-
>tr|Q4YWH2|Q4YWH2_PLABA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium berghei (strain Anka) GN=PB000415.02.0 PE=3 SV=1
----KVRCFNNKTFKGIGNAGVLPWKCNLIDMKYFSSVTSYINENNLQNIVVMGKKSWESIPKKFKPLQNRINIILSRTLKKEDINNVIIIKSVDDLFPI
LK----CTKYYKCFIIGGSSVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFKIT-----SISDVYNSNNTTLDFIIYSKT-
>tr|A0A060DCC5|A0A060DCC5_PLAFA Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) OS=Plasmodium falciparum GN=dhfr-ts PE=4 SV=1
----KNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFRAVTTYVNEKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFEDVYIINKVEDLIVL
LG----KLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQII-----SVSDVYTSNNTTLDFIIYKKT-
>tr|Q95US9|Q95US9_PLAGA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium gallinaceum GN=DHFR/TS PE=3 SV=1
----KNEIFSNNTFRGIGNKGVLPWKSNPLDMKYFTTVTTYVNENNLQNVVVMGRTSWESIPERFRPLVNRINVVLSRSLKKEDIGDAILINNVDDLLLL
LR----KINYYKCFIIGGSVVYNEFLKRNLIKKIYFTRINSTYECDVFFPEIKETEFEIM-----SLSDVYSNNGATLDFVIYKRK-
>tr|U3M190|U3M190_9APIC Dihydrofolate reductase-thymidylate synthase (Fragment) OS=Plasmodium cynomolgi GN=dhfr-ts PE=3 SV=1
----KNEPFSSRTFRGLGNNGNLPWKGNSVDMKYFSSVTTYVDETKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTYEHVEKVFIINSIDDLLLL
LK----KLRYYKCFIIGGAQVYRECLSRNLIKQIYFTRINNAYQCDVLFPEFDEGQFRVT-----SVSEVYNNKGTTLDFVIYSKV-
>tr|A8C2U2|A8C2U2_PLAMA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium malariae PE=3 SV=1
----KNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNESKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKEDVEDIFIINNMDQLVLL
LK----KLNYYKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEIDENVFQIT-----SVSDVYTSNCTSLDFVIFSKR-
>tr|A0A0J9SG59|A0A0J9SG59_PLAVI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium vivax India VII GN=PVIIG_02993 PE=3 SV=1
----KNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFRSVTTYVDEDKLQNVVVMGRSNWESIPKQYKPLPNRINVVLSKTLTKEDVEKVFIIDSIDDLLLL
LK----KLKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVT-----SVSEVYNSKGTTLDFLVYSKV-
>tr|U3M1V1|U3M1V1_PLAHY Dihydrofolate reductase-thymidylate synthase (Fragment) OS=Plasmodium hylobati GN=dhfr-ts PE=3 SV=1
----KNEPFGRNTFRGLGNNGTLPWKCNSVDMKYFTSVTTYVDETKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLSREEVEKVFIIHSIEDLLLL
LK----KLKYYKCFIIGGAQVYKECINRNLIKQIYFTRINNAYPCDVLFPEFDENQFRVT-----SVSEVYNCKGTTLDFLIYSKV-
>tr|A0A0D9QQP1|A0A0D9QQP1_PLAFR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium fragile GN=AK88_01173 PE=3 SV=1
----KNEPFSPRTFRGLGNNGTLPWKCNSVDMKYFSSVTTYVDETKLQNVVVMGRSSWESIPQQYKPLPNRINVILSKTLTSENVEKVFIIHSIDDLLLL
LK----KLKYYKCFIIGGAQVYKECLNRNLIKQIYFTRINKAYQCDVMFPEIDESQFRVT-----SVSDVYNSKGVTLDFVIYSKV-
>tr|G3MHL1|G3MHL1_9ACAR Putative uncharacterized protein (Fragment) OS=Amblyomma maculatum PE=2 SV=1
-----FAIAAMCRNRGIGFKNALPWR-LKKEMAFFKRMTS-EAAEGKQNAVVMGRNTWESIPPKFRPLNNRINVVVSKTLTEVPEG-HHVASSFPAALQL
LQTLVDTGKVDKVFLVGGAQLYREALESGHCTRIYLTEVDKDFECDVFFPEFDNSVFSPVEE-EGVPQEPQQEDGVTFRFRVYER--
>tr|V5HNV0|V5HNV0_IXORI Putative dihydrofolate reductase OS=Ixodes ricinus PE=2 SV=1
-----FAIAAMCQNRGIGVLNTLPWR-LKKEMAYFSRITS-EAAEGKSNAVVMGRNTWDSIPPKYKPLPGRVNVVVSRTLDKVPDG-HHVARSFSDALSL
IQPLVDGGQVDKTFVVGGAQVYREALADPRCTRVYLTEIDADFDCDVFFPELEPGQFQLVQE-EGVPQEVQTEGDLTYRFNVYQR--
>tr|L7MJG0|L7MJG0_9ACAR Putative dihydrofolate reductase (Fragment) OS=Rhipicephalus pulchellus PE=2 SV=1
-----FAIVAMCRNRGIGVNNSLPWR-LKKELAYFTRLTK-EAAEGKQNAVVMGRLTWESLPPKSRPLSDRINIVVSKTLTEIPEG-HHVVRSFADAVQT
LQNLVDAGKVDKVFVIGGAQLYRELIESPHCSRIYLTEIDKEFECDVFFPEFDTSRFRLVKE-EGVPEEPQQEGDITYHFRVYER--
>tr|A0A059WZ24|A0A059WZ24_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
------VVAATSNTFGIGRKGTLPWK-IAEDMEFFKTITSTASS-GKINAVIMGRKTYESIPAKFKPLSGRTNVILSRNPENLPESVH-VKSNLSDALNL
LKE---DQAIDRIFVIGGESVYREALESKFCSKIYLTEVNDIPDIDTFFPVIRANVFRMTQRG-----EEKSNGELKYRFTEYEQ--
>tr|G0UQH6|G0UQH6_TRYCI Putative uncharacterized protein TCIL3000_7_4510 (Fragment) OS=Trypanosoma congolense (strain IL3000) GN=TCIL3000_7_4510 PE=4 S
------IVVAADENGGIGENGTIPWE-IPEDMKHFKNLTTKIRGKTRRNAVVMGRKTWDSLPAKFRPLSNRLNVVLSRSATAENDILV-INGGLSDALKV
LVQSPYISSIETVYCIGGGTLYSEAISSPCVQAVHRTVVRASESCNVFFKLPTTHSESESAMELVRVTEERVGCGRKYQ--------
>tr|T0R0G8|T0R0G8_9STRA Uncharacterized protein OS=Saprolegnia diclina VS20 GN=SDRG_16667 PE=4 SV=1
------IVAVARATNGIGIKGQLPWR-LAGDLKRFRELTTSTA-DTKQNAVVMGRKTWDSLPPKHRPLPGRVNVVLSRNPASAQTGVL-AAGDLDEALGA
LTD------VEHVFIIGGQSLYEEAAQHPRCTRAYITLVDGEYECDAFFPKSLASCFVETSVS-----PAQIEKDILF---------
>tr|A0A059WZL2|A0A059WZL2_9BACT Thymidylate synthase OS=uncultured bacterium PE=4 SV=1
------VVAATHVSQGIGRAGTIPWK-LKGDMQYFKDVTSTVTKASLQNAVIMGKKTYLSIPVKFRPLVGRINVVLSRSSGGLPDTVL-TASSLEEALQL
LSSPSVESRIDQIFVIGGASVYKEALESPRCGTIYLTKILEYPDMDTFFPIIPADKFTLTSRT-----QVTTENDISYQFCTFDP--
>tr|R9K3S8|R9K3S8_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium M18-1 GN=C808_00279 PE=3 SV=1
----MNIIVAVDKNWAIGKNNKMMWS-IPADMRFFREKTT-----G--HVVVMGRKTLESFP-NGLPLKQRTNIVLSTDRNYVK-GAL-VLHTMEDLLE-
----HLKHDKTEIFIIGGESIYRQFLPF--CDTAYVTKIDHAYDADTYFPNLDQPEWTMTEVSEE-----HTSFDLEFVFTKYERK-
>tr|R5ELV8|R5ELV8_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:110 GN=BN466_02226 PE=4 SV=1
----MELIVAVYDDWGIGRDGTQPVA-LSADRKFFRVTTR-----G--AMVIAGRRTIEDFP-GKQPLPGRVNVALSRSVT-LP-GFT-VCGSAEDAAR-
----------ERCFVIGGGSVYRQMLPF--CDTAYVTKVHVTPESDTFFPNLDEKDWYLAETLQS-----GEENGIAYEMCLYKRK-
>tr|R5D374|R5D374_9FIRM Dihydrofolate reductase OS=Dorea sp. CAG:105 GN=BN457_02045 PE=3 SV=1
----MKLIVAVDKNWAIGKNNRLMWS-IPADMKFFRETTK-----G--NIVIMGRKTLESFP-QSQPLKNRVNIVISKNPDYVK-DAV-VVHSVEEALE-
----EAK---GETFVIGGESIYRAMLKY--CDTALVTKIDHAYDADTYFPSLDEPEWKMTKISEE-----QTCFDLEYYFTVYERI-
>tr|R9NBT6|R9NBT6_9FIRM Dihydrofolate reductase OS=Dorea sp. 5-2 GN=C817_01625 PE=3 SV=1
----MNLIVAVDKNWAIGKNNRMMWS-IPADMKFFRETTS-----G--NIVIMGRKTLESFP-QGQPLKNRVNIVISGNPDYVK-GAL-VVHSVEEAVK-
----EAG---GEIYVIGGESIYRAMLPL--CDTAYITKIDHAFDADTYFPDLDAEGWRMTKISEE-----QTCFDLEYYFTVYERI-
>tr|R5XDT5|R5XDT5_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:212 GN=BN537_00035 PE=3 SV=1
----MNAIAAVDVNWAIGNKNRLLTS-IPADMKFFREKTM-----G--HVVVMGRKTLESFP-NGLPLKNRVNIVLTANRSYVK-DAI-IVHTKEELLE-
----ELK---NELYVIGGGSIYEMLIPY--CDTAYITKIDHAYAADTYFPNLDQDDWEMTEVSEE-----QTCFDLEYVFAKYERK-
>tr|X8GVB4|X8GVB4_9FIRM Dihydrofolate reductase OS=Shuttleworthia sp. MSX8B GN=folA PE=3 SV=1
----MKMIVAVDRNWGIGKKGKLLIS-IPEDMKFFRRTTL-----H--QVVVMGRKTLDSFP-HGMPLKDRVNIVLTRDARFRE-GVI-VVHSIEELQS-
----VLK---REVYVIGGESVYRQLEPF--CDLAYVTKIDYSYDADAHFPNLDQEEWECADASEE-----QTYYDTEYYFTSYRRR-
>tr|R6WKU7|R6WKU7_9FIRM Dihydrofolate reductase OS=Dorea sp. CAG:317 GN=BN605_00951 PE=3 SV=1
----MHLIVAVDKNWAIGKNNKLMWS-IPADMKYFRETTK-----G--NIVIMGRKTLESFP-QGQPLKNRVNIVITNNKDYVK-DAV-VVHSIEEAIE-
----EAK---GTPYVIGGESIYRAMLPY--CDTALITKIDHAFDADTYFPNLDEEEWEMTKISEE-----QTCFDLEYYFTVYERV-
>tr|A7B732|A7B732_RUMGN Dihydrofolate reductase OS=Ruminococcus gnavus ATCC 29149 GN=folA PE=3 SV=1
----MNAIVAADKNWAIGYKNKLLVS-IPADMKFFRQMTG-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTGNPNYVK-DAV-IVHTTEELLE-
----ELK---EEIFVIGGESIYRMMLPY--CSKVYVTKIDHAYQADTYFPNLDQENWEMTEVSEE-----HTCFDLEYVFSTYERR-
>tr|I9LFK4|I9LFK4_9FIRM Dihydrofolate reductase region OS=Pelosinus fermentans B4 GN=FB4_2979 PE=4 SV=1
----MKLIVAVDEQWGIGCKGQLLVT-IPADMQHFKEKTK-----G--KVIVMGRETFESLP-GSKPLQGRINIVLTKNIKLWE-GVT-LCHSLSQLFAS
---Y------EDIFIIGGESVYRQCLPY--CSEAYVTKISNMHPADTCFPNLDSPEWQCIEESSV-----QSYKDSTYRFTTYINL-
>tr|N9XDS2|N9XDS2_9CLOT Uncharacterized protein OS=Hungatella hathewayi 12489931 GN=HMPREF1093_03058 PE=4 SV=1
----MNILVTVDKNWAIGNQGQLLVS-IPEDQRLLREETQ-----G--GIIVMGRKTFETLP-GKQPLYGRINVILSKDRNYVK-GAV-VCHSLEETLKQ
----------ASVFIIGGSSIYDQFLPY--CDTVHATFIDYEYSADTHFPDLDKGEWSLTAESDE-----HTYFNLCYSFRMYQKK-
>tr|R5R8G1|R5R8G1_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:194 GN=BN526_01617 PE=3 SV=1
----MKLIVAVDSNWGIGLRNALLVH-IPSDMKFFRSETM-----G--KTIIMGRKTLESFP-QAQPLAGRNNIVITKDPAYVK-GAV-VVHSIEEAIE-
----ESK---TDVYCIGGESVYRQLLPY--CDEAFITKIDHAYEADSFFPNLDEPEWEMTETSDE-----QTYFDLEYTFTKYERK-
>tr|R5Z803|R5Z803_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium CAG:25 GN=BN562_00265 PE=3 SV=1
----MNLIVNADKNWGIGKNNELLVH-IPNDMKMFRQMTT-----G--KVVVMGRKTLESFP-NGMPLPKRTNIVLTHDKDYAK-GAI-VVGSKEELLD-
----ELE---EDIFIIGGESIYRMMLPY--CDTAYVTRTDFAYDADTYFPDLDEPEWKLVKESEE-----ETYFDIEYQFLVYQK--
>tr|D4IZ19|D4IZ19_BUTFI Dihydrofolate reductase OS=Butyrivibrio fibrisolvens 16/4 GN=CIY_01280 PE=3 SV=1
----MNLIVAVDRNWAIGKDNKLLVS-IPDDMKFFRETTT-----G--KVVVMGRKTLESFP-NGKPLKNRVNIVLTRDPKYVK-DAI-VVHSKEELDK-
----ELA---DDIYVIGGESIYRMLLDD--CSRAFVTYVDYSYDADTYFPNLDEPEWKLAEESEE-----QTYYDIEFYFRTYVK--
>tr|F3ADW3|F3ADW3_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 6_1_63FAA GN=HMPREF0992_01258 PE=3 SV=1
----MNLIVAVDRNWGIGKDNKLLVS-IPADMKFFRTTTT-----G--KVVILGRKTLETFP-NGLPLKNRVNIVLTRDKNYVK-DAI-VLHSVEEVLE-
----EIK---EDLYVIGGDSIYKQFLPY--CDKAHVTKIDFAYEADAFFPNLDEPEWKVTERSEE-----QTYFDIEYEFLTYEKK-
>tr|R5QEI7|R5QEI7_9FIRM Dihydrofolate reductase OS=Ruminococcus torques CAG:61 GN=BN734_00964 PE=3 SV=1
----MRAIVCADKNWGIGYKNRLLVS-IPSDMKFFRETTT-----G--KVIVMGRKTLESFP-NGMPLKNRINIVLTRDRNYAK-GAV-IVHDEEELMN-
----ELG---EQIYIIGGESVYKMMLSY--CDKIYVTKVDRAFQADTYFPNLDESEWKMTQESEE-----QTCFDLEFCFTTYERC-
>tr|R7APJ1|R7APJ1_9BACE Dihydrofolate reductase OS=Bacteroides pectinophilus CAG:437 GN=BN656_00196 PE=3 SV=1
----MNMIVAVDSNWAIGHKGKLLVS-IPEDMQFFRRETT-----G--KVVVMGRKTLESFP-NGLPLKNRVNVVITKDKEYVK-DAI-ICHSIEEALE-
----VLK---EDIYVIGGESVYRQFLPY--CSVAHVTKINYSYDADTYFPNLDEDEWTIEESSDE-----RTYFDLEYEFVKYVKK-
>tr|F7JQJ3|F7JQJ3_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 1_4_56FAA GN=HMPREF0988_02628 PE=3 SV=1
----MNVIAAVDSNWAIGNKNRLLTS-IPADMKFFREKTS-----G--HVVVMGRKTLESFP-NGLPLKNRTNIVLTGNRDYVK-DAV-IVHTKDELLE-
----ELK---EEIYIIGGESVYRMMLPY--CDTAYITKIDHAYEADTHFPNLDEEDWKMTQVSDE-----QTCFDLEYVFSVYRRG-
>tr|D4M6M6|D4M6M6_9FIRM Dihydrofolate reductase OS=Ruminococcus torques L2-14 GN=RTO_24020 PE=3 SV=1
----MQAIVAADNNWGIGYQNRLLVS-IPSDMKFFRQKTT-----G--NVVVMGRKTLESFP-NGLPLKNRVNIVLTKNKNYVK-DAV-IVHSEEELLE-
----ELK---EKIYVIGGESIYKMMLPY--CDTVYVTKIDREFQADTYFPNLDQEDWKMTEEGEE-----QTCFDLEFAFTKYERC-
>tr|R6VLM7|R6VLM7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:227 GN=BN546_02159 PE=3 SV=1
----MNIIVAVDKNWAIGKENKLLVS-IPADMKFFRSTTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTKDKNYVK-DAI-IVHSIEEALE-
----ELK---EDVYVIGGDSIYAQMLPY--CDTAHVTKIDFGYEADAWFPNLDEEEWKIAEESEE-----QTYFNLEYSFVKYVRK-
>tr|R5X2J6|R5X2J6_9FIRM Dihydrofolate reductase OS=Blautia sp. CAG:257 GN=BN568_00656 PE=3 SV=1
----MNIIVAVDKNWAIGKDNKLLVA-IPADMKMFRQETT-----G--KVIVLGRKTLETFP-RGLPLKNRTNIILTTNKDFVK-DAT-VVHSIEELLE-
----EIK---DQVYCVGGDSVYKQLLPY--CDTAHVTKIDFGYEADRYFPNLDEPEWEITARSEE-----QTYFDLEYEFVKYERV-
>tr|U2CDP7|U2CDP7_9CLOT Dihydrofolate reductase OS=Clostridium sp. KLE 1755 GN=HMPREF1548_04870 PE=3 SV=1
----MNIIVAVDENWAIGYRGDLLVR-IPADHKMFRNETI-----G--KVVVLGRKTMDTFP-GGLPLAGRTNIVLTRNPEYVK-DAI-VVHSVEELLA-
----ELK---KDVYVIGGDSVYSQLLPY--CDTAHVTKIDRSYEADTYFPNLDAGEWEITAESDE-----QSYFDTTYHFLKYERK-
>tr|D4LWB7|D4LWB7_9FIRM Dihydrofolate reductase OS=Blautia obeum A2-162 GN=CK5_02970 PE=3 SV=1
----MNIIVAADKNWAIGKDNKLLVS-IPADMKMFRQETT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTGNKNYVK-DAI-IVHTIEELLE-
----EIK---EEVYCIGGDSVYKQLLPY--CDTAHVTKIDFGYEADSYFPNLDGPEWKITAESDE-----QTYFDLEYSFVKYERV-
>tr|B5U212|B5U212_9BACT Putative uncharacterized protein OS=uncultured bacterium PE=4 SV=1
----MNAIVAVDNNWAIGNKGKLLVS-IPNDMKRFREITT-----G--KVVVLGRKTMATFP-NGMPLKNRTNIVLTKDEKYAG-DAV-VVHSIDELLKK
---Y------ADVYIIGGDSVYKQMLPY--VDTCEVTKINYCYEADSYFPNLEKDEWKKTGESEE-----FTYFDTEYTFERWKRK-
>tr|R7CJA6|R7CJA6_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. CAG:9 GN=BN806_02039 PE=3 SV=1
----MNVIVAADKNWGIGKNNQLLVS-IPADMKMFREETS-----G--KVVVMGRKTLESFP-NGLPLKNRINIVITSNKEYVK-GAI-IVHSIEEALE-
----EIK---EDVYCIGGDSIYAQMLPY--CDVAHVTKIDFAYEADSHFPNLDEDEWEITGESDE-----QTYFDLEYQFVKYERK-
>tr|H1PIN5|H1PIN5_9FIRM Dihydrofolate reductase OS=Eubacterium infirmum F0142 GN=HMPREF0380_00043 PE=4 SV=1
----MNLIIAVDKNWGIGKDGGLLCH-IPGDLEYFKKMTL-----D--KTVIMGRVTLESLP-GSKGLPRRRNIVLTRDTSYAV-NAE-LVHSYEEIDSC
---L------EDVFVIGGAQIYKDMLPK--CDICYVTKIYKDFDADRYFENLDVGEFDCEPVGEL-----MEEKGIEYRFYKYTRK-
>tr|R7R072|R7R072_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:182 GN=BN520_02171 PE=3 SV=1
----MNLIAAVDKNWAIGYQNKLLTS-IPEDMKFFRQTTT-----G--KVVVMGRKTLESFP-GKKPLKNRTNIVLTKNPSYAE-GAI-VVHNEDELRE-
----ELK---EDIFVIGGGSIYRQLLDE--CDKAYITKIEYAYTADAYFPNLDEEEWKITAESEE-----HTCFDLEYFFLIYEKN-
>tr|A6P1N6|A6P1N6_9FIRM Dihydrofolate reductase OS=Pseudoflavonifractor capillosus ATCC 29799 GN=folA PE=3 SV=1
----MYLIAAVDQNWAIGYQNKLLAR-ISPDLKRFKALTL-----G--HPVLLGRKTLETFP-GGKPLPGRQNYILSTNPDYVE-NAV-VLHSLEEAK--
----------ADTFVIGGGQVYRAALDW--CDTAYITKIHASFEADAWFPNLDDPEWELAEEEPV-----LEDGGLSFHYATYRRK-
>tr|R6Q4G3|R6Q4G3_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:466 GN=BN668_01930 PE=3 SV=1
----MNLIVAVDENWGIGKDNELLCR-ISADMKNFRAVTM-----G--HVLVLGRKTLESFP-GKKPLPKRTHIVLTANKAYAE-GVI-LCHSLEELPAD
---Y------DDIFVIGGGSIYEQLLPQ--CKKAYITQIYDKFPADTYFPNLDEPEWTLTEKGEVQ------ENGVKFSFDIYEQK-
>tr|R5LCH0|R5LCH0_9FIRM Dihydrofolate reductase OS=Butyrivibrio crossotus CAG:259 GN=BN569_00449 PE=3 SV=1
----MNLIAAVDKNWAIGYKNELLVR-IPEDQKWFRETTT-----G--KAVIMGRKTLESFP-NKRPLKNRTNIVITKDMNYVD-GAI-VVHSIEEAVE-
----AAK---EDIYVIGGASIYKQMLPL--CNVAHITKIDYAYDADSYFPNLEDEGFVITESSDE-----RTYFDLIYEFVKYERK-
>tr|R5DU48|R5DU48_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:86 GN=BN798_02160 PE=3 SV=1
----MKLIAAVDKNWGIGRNNRLLVN-IPEDMQLFRQETN-----G--KVVIMGRKTFESLK-EKSPLYGRKNIVLTTNKSYAK-GAV-VCASVEEVLD-
----AVK---NDIYVIGGGEIYKEFLPY--CDVAHITKIDYKYDADTYLENLDKSEWHITANSEE-----KTYFDIVYEFVKYEKK-
>tr|R5ZQ16|R5ZQ16_9FIRM Dihydrofolate reductase OS=Eubacterium eligens CAG:72 GN=BN765_00616 PE=4 SV=1
----MNLIATVDKNWAIGKQGHLLVN-IPEDIKLFRMETA-----G--KAAIMGRKTYEQIT-DRTALIDRYNVVLTSDLSYKD-GVV-VVHSVEEALAS
----------EDIYVIGGESVFEQFLPY--CDVAHITSVDYKYDADAHFPNLDKPEWKVTQMSEE-----HTYFDLCYEFKKYCKM-
>tr|R6K3G9|R6K3G9_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:248 GN=BN561_01604 PE=4 SV=1
----MNIIALADKNWAIGNNGRLLVD-IPEDKKLFRGETY-----G--KVVVMGRKTYEGLP-NQSALEGRKNIVLTNNLNYAK-DVL-ICHSVQEVLKS
----------KDVYIIGGGQIYEQFLPY--CDTAHITRVDYKYQADTYITDFDKDGWRVTARSEE-----HTYFDICYEFVCYQKE-
>tr|R7H6W8|R7H6W8_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:38 GN=BN634_01980 PE=3 SV=1
----MNLIAAVDRNWAIGKAGRELVN-IPEDKKFFREETT-----G--KVIVMGRKTFESLP-GAMALAGRTNIVLSENPGFPK-NTI-VCRSFEETKE-
----ELA---EDIYIIGGGSIYKQFLPL--CDTAHITKVDYKYDADTYFPNLDKSEWEIKETSEE-----KTYFDMIYEFVRYSRK-
>tr|R5CBX7|R5CBX7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:791 GN=BN785_01724 PE=4 SV=1
----MQAIVAVDRNWGIGYKGSLLVS-IPNDHKMFRQETK-----G--KTIIYGRKTLETFP-MAQPLDQRRNVILSGNPAYVR-GAE-VVHSIEELLKD
---E------DSLMVIGGASVYKELLPY--CDTIHVTMVDYAYEADAYFPDLDAPEWEKTMEGEE-----QTYFDIPYTFVKYERV-
>tr|R5ZIC7|R5ZIC7_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:156 GN=BN504_00018 PE=3 SV=1
----MNLIVAVDNNWAIGYKNDLLIS-IPDDMKFFRETTT-----G--NVIIMGRKTLNSFP-NGKPLKNRVNIVITKDANFAD-GAI-VVNSIEEAVK-
----EAE---KEAYVIGGGSIYEQMLPY--CDTAYVTYIDNSYSADTFIPNLDKEEWYIANESDE-----CTYFDIEYYFRTYKRK-
>tr|R5P624|R5P624_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:603 GN=BN730_01845 PE=3 SV=1
----MNLIVAVDKNWAIGNKGKLLLS-IPDDMKFFRETTT-----G--NVVVMGKTTLKSFP-NERPLKNRVNIVLTRDNNFAQ-DAI-IVHSIDETLE-
----ALK---ENVYVIGGASVYEQLLPY--CDTAYVTYIDYAYEADRYFPNLDKSDWKLTEESEE-----QTYFDVEYYFRKYERV-
>tr|R6FW58|R6FW58_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:192 GN=BN525_01458 PE=3 SV=1
----MNLIVAVDKNWAIGNNNELLVS-IPDDMKFFREHTT-----G--NVIIMGKKTLESFP-GKRPLKNRVNIVITKNQNYVD-GAI-VVHSIEEAVE-
----KAK---EDVYVIGGGSIYKQMLPY--CDTAYVTYIDHQYAADTFIPNLDEDQWELAEESDE-----NTYFDLEYYFRTYKRK-
>tr|A5Z9U9|A5Z9U9_9FIRM Dihydrofolate reductase OS=Eubacterium ventriosum ATCC 27560 GN=folA PE=3 SV=1
----MNLIVAVDENWAIGYNNELLVS-IPDDMKFFRETTT-----G--KVVIMGRKTLESFP-GGRPLKNRVNIVITKKEDYVD-GAV-VVHSVEEAVK-
----EAS---NDVFVIGGGSIYKAMLPY--CNTAYVTYINQAYSADTFIPNLDKVDWVLADESDE-----NTYFDIEYFFRTYKRK-
>tr|R5L731|R5L731_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:161 GN=BN508_01665 PE=3 SV=1
----MNLIVAVDKNWAIGYKNDLLVS-IPDDMKFFRETTT-----G--KVVIMGKNTLESFP-NSKPLKNRVNIVIALEKDYVD-GAT-VVYSIEEALE-
----EAK---EDVFVIGGGSIYKQMLPY--CDTAYVTYVDYEYAADTFIPNLDEDEWEMVEESEE-----NTYFDLEYYFRTYKRK-
>tr|R6BWN3|R6BWN3_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:510 GN=BN687_00521 PE=4 SV=1
----MNIIVTVDENWAIGKGGDFLTR-IPAEQRNTDSLTL-----G--KTIIMGRKTLQALP-QGQPLYGRENIILTQDAQ---FGVT-VAHSVEELEAE
---K------ESIFVYGGESVFKALLPK--CDTAYVLYIEKSY-ANRFFENLDREGWELTEESDEQ----T-YFDITYYFRKYERK-
>tr|R5BZI6|R5BZI6_9FIRM Dihydrofolate reductase OS=Blautia hydrogenotrophica CAG:147 GN=BN499_02915 PE=3 SV=1
----MNIIVAADKNWGIGKDNKLLVS-IPADMKFFRETTT-----G--NVVVMGRKTLESFP-GGLPLKRRTNIVLTKDVNYVK-DAV-LVHSVEELLE-
----ELK---ENVYVIGGDSVYRQLLPY--CDIAHVTKIDYAYEADSYFPNLDEPQWEVTASSEE-----QTYFDLEYTFVKYQRK-
>tr|R5RE09|R5RE09_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:646 GN=BN747_01755 PE=3 SV=1
----MNLIVAVDKNWGIGNNNKLLVS-IPSDMKFFRQETS-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTSDPSYVK-DAI-IVHDLPELLK-
----ELK---DQIYVIGGGKVYEELLPY--CNLAHVTKIDFAFEADTYFPNLDEEEWEITASSEE-----QTYFDLEYTFVKYERK-
>tr|S2Y237|S2Y237_9FIRM Dihydrofolate reductase OS=Coprococcus sp. HPP0074 GN=HMPREF1215_01663 PE=3 SV=1
----MNIIVAVDKNWAIGKDNKLLVS-IPSDMKFFRETTT-----G--KVVVMGRKTLESFP-GGQPLKKRTNIVLTSDRNYVK-DAI-VVHTVEELLQ-
----TLK---EDIYVLGGESVYRQLLPY--CDTAHITKIDHVYEADTYFPNLDTEEWEITGISEE-----QTYFDLEYEFVKYERK-
>tr|R6H5S8|R6H5S8_9FIRM Dihydrofolate reductase OS=Blautia sp. CAG:52 GN=BN690_00691 PE=3 SV=1
----MNLIVAADKNWGIGKDNKLLVS-IPSDMKFFRQETM-----G--KVVVMGRKTLESFP-NGLPLKNRTNVVLTSDKNYVK-DAV-IVHSIDEVLE-
----ELK---DEIYVIGGGKVYEELLPY--CDVAHVTKIDFAFEADTHFPNLDETEWEITAASDE-----QTYFDLEYTFVKYERK-
>tr|R5HPW0|R5HPW0_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. CAG:60 GN=BN729_00891 PE=3 SV=1
----MKIIVAADKNWGIGKDNKLLVS-IPADMKMFRQETT-----G--KVCVMGRKTLESFP-GGLPLKNRTNIVLTHNQNYVK-DAV-IVHSIEELME-
----ELK---EDVYCIGGDTIYRQLLPY--CDVAQVTKIDFAYIADSYFPNLDEPQWQKAAESEE-----QTYFDLEYKFVRYERN-
>tr|R6PIB1|R6PIB1_9CLOT Dihydrofolate reductase OS=Clostridium nexile CAG:348 GN=BN618_01633 PE=3 SV=1
----MNLIVAVDKNWAIGLHNKLLVS-IPADMKFFRETTM-----G--KVVVMGRKTLESFP-GGQPLKKRTNIVLTSDKNYVK-DAV-VVNSVEALLE-
----ELR---EDIYVIGGESIYRQLLPY--CKVAHITKIDHAYEADTYFPNLDEPEWKITGVSEE-----QTYFNLEYEFVKYERI-
>tr|R6RPG1|R6RPG1_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:424 GN=BN652_01722 PE=3 SV=1
----MNLIVAADANWGIGRENKLLVS-IPADMKFFRTTTT-----G--KVVIMGRKTLESFP-GGLPLKNRVNIVITRDKNYVK-DAV-VVHSIEEALE-
----EAK---EDVYVIGGDSIYKQMLPY--CTKAHVTKIDFAYEADTFFPNLDEEQWEVTERSEE-----QTYFDLEYEFRTYERK-
>tr|D4LPD3|D4LPD3_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. SR1/5 GN=CK1_00420 PE=3 SV=1
----MNIIVAADKNWGIGRNNELLVS-IPADMKMFREETT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVITGNRDYVK-GAV-IVHSIEEALK-
----EVE---EDVYCIGGDSIYKQMLPY--CDTAHVTKIDFAYEADAYFPNLDEPDWEITAESEE-----QTYFDLEYAFVKYERK-
>tr|K1R735|K1R735_9ZZZZ Dihydrofolate reductase OS=human gut metagenome GN=OBE_17282 PE=4 SV=1
----MNLIVAVDNNWAIGSKNELLIR-IPNDHKHFREETT-----G--KVVVLGRKTLETFP-QGMPLKNRINIILSKDPNYVK-DAI-VVHSIEELLE-
----ELK---ENIYIIGGESIYRQMLPY--CDVAHVTKIDHAYEADAYFPDLDSPEWEITADSDE-----QVYFDITYQFLKYERK-
>tr|R5J308|R5J308_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:7 GN=BN757_02698 PE=4 SV=1
----MKFLVTADNNGAIGRGAQPLVT-IPAMQQSFLKETQ-----G--KVVVMGRKTLEGLP-GGQPLGNRVNVVLSENPAYIK-GAV-VCHNIDEALKQ
----------EDIYVIGGESIFRQFLPY--CNTVYLTHIDYEYDADVKFPNLWKQEWEMVEEGEE-----QTYFSLCYTPEIFVRK-
>tr|C5ENL6|C5ENL6_9FIRM Dihydrofolate reductase OS=Clostridiales bacterium 1_7_47FAA GN=folA PE=4 SV=1
----MNIIVAADRHWAIGKDGRGLVT-IPADQQMLMRETA-----G--KVVVMGRKTLEGLP-GGQPLGSRVNVVLSRNEDYVK-GAQ-VCGSMAKALSA
----------DDIYIIGGLSIYEQFLPH--ADTVHVTRIDYTYDADTFFNNLEKEAWEMVQESDE-----QTYFDLCYTFQKFQRK-
>tr|N9ZHB9|N9ZHB9_9FIRM Dihydrofolate reductase OS=[Clostridium] bolteae 90B8 GN=HMPREF1097_01972 PE=4 SV=1
----MNLCVTADRHWAIGKDGRPLVT-IPADRQMFLKETA-----G--KVVVMGRRTLEGLP-GGQPFGNRVNIVLTHDMQYVK-GAV-VCHSLEEALKD
----------GDIYIIGGESVYRQFLPY--CTTAHVTSIDYTYDGDAYFPDLEEEGWYLAEEGDE-----QTYFDLCYTFRRFRRK-
>tr|R6I4S6|R6I4S6_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:240 GN=BN556_01755 PE=4 SV=1
----MDAIVAVYSDWGIGADGTQPVV-LKADRQHFVELTR-----G--RTVIVGRKTLADFP-GGRPLKGRRNIVLTRQNAA--IGAE-IAHSPEQAR--
----------DDAMVLGGQSVFRDMMPY--IDRVFVTKINCCP-SDSYFENLDAADWRIASQSEA-----LREGDIEYSFVCYERI-
>tr|D5HGI0|D5HGI0_9FIRM Dihydrofolate reductase OS=Coprococcus sp. ART55/1 GN=CCU_27850 PE=4 SV=1
----MKFIAAVDKNWAIGNKGRLLIR-ISEDQRNFRQTTM-----G--HVVVLGRKTLEEFP-GGRPLKGRANIILSRNPEYVE-DAV-VVHSMNELFAK
---Y------DDIFVIGGQTIYDELIPY--CDEAVITKIDREFEADAFISNLDKDNWDVTDERPG-----EDVSEVNFTFVTYKNS-
>tr|R6WUJ1|R6WUJ1_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:349 GN=BN619_00764 PE=4 SV=1
----MKTIVAVDEKWGIGKNNGLLFA-IPEDMRFFRETTL-----N--KVVVMGSNTLKSFP-GGKPLKNRVNIVLWPDGEED-D-VV-IVRSLDELSSA
---Y------DDVFIIGGAMFYKTMLPY--CDTAYITKVRADG-AQVFFENLDESCWSLEKESELI----N-NGQYKFSFCTYKNK-
>tr|R7K4H4|R7K4H4_9FIRM Dihydrofolate reductase OS=Subdoligranulum sp. CAG:314 GN=BN603_00626 PE=4 SV=1
----MNAIVVVDKKWGIGKNNDLLFK-LPEDMKYFRQKTL-----N--KIVVMGSNTLKSFP-DGKPLKNRTNAVLFPGGEKD-D-CI-VADSLEELRTS
---F------DDIFIIGGAMMYKTMLPF--CKRVYVTKVDADG-ASVFFPDLDR-GWTLSERVAKK----R-DGEYELEFVVYSNP-
>tr|C5ENL5|C5ENL5_9FIRM Dihydrofolate reductase OS=Clostridiales bacterium 1_7_47FAA GN=folA PE=3 SV=1
----MNLIVAVDEKWGIGKNGGLLTH-LPGDMKYFRETTR-----G--KVVVMGRKTLESFP-DGKPLKNRVNIVLTKNREYPE-GVT-VCHDADQVLKQ
---Y------EDIFIIGGGMIYREFLPY--CSKAYVTCIHHVFEADTDFVDLDRGEWEVTSCSQMQ------YNGLTYEFKVYSRR-
>tr|C6LEJ1|C6LEJ1_9FIRM Dihydrofolate reductase OS=Marvinbryantia formatexigens DSM 14469 GN=folA PE=3 SV=1
----MNLIVAVDKNWAIGKDNKLLVS-IPADMKFFRQTTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTGNKNYVQ-DAI-IVHSLEELKS-
----ELK---EDIYVIGGDSVYRQLLPY--CSLAHVTRINHAYEADTWFPNLDEEGWQIAGDSDE-----QTYFDLEYGFMLYQNR-
>tr|V8CBB4|V8CBB4_9FIRM Dihydrofolate reductase OS=Ruminococcus lactaris CC59_002D GN=HMPREF1202_00730 PE=3 SV=1
----MKAIVAADRNWGIGYQNRLLVS-IPSDMKFFRQTTT-----G--HVVVMGRKTLESFP-NGLPLKNRTNIVLTANKDYVK-DAI-IVHSEKELLE-
----ELK---DEIYVIGGESVYRMMLPY--LDTIYVTKIDHAFQADTFFPNLDEEDWEMTEEGDE-----QTCFDLEFAFTRYERR-
>tr|F0YV77|F0YV77_9CLOT Dihydrofolate reductase OS=Clostridium sp. D5 GN=HMPREF0240_01047 PE=3 SV=1
----MNLIASADKNWGIGFKNKLLVS-IPTDMKFFRQTTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVMTANRDYVK-DAV-IVHTLEELLE-
----ELK---DEIYVIGGERIYRQLLPY--CDTAYITRIDHAFQADTFLPDLDAEEWKMTEEGEE-----QTCFDLEYRFTKYQRQ-
>tr|A0A0J1G5L5|A0A0J1G5L5_9FIRM Dihydrofolate reductase OS=Robinsoniella sp. RHS GN=RHS_3591 PE=3 SV=1
----MNFIVAVDKNWGIGNENKLLVS-IPADMKFFRETTS-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTGNKDYVK-DAV-IVHSMEELQE-
----ELK---DDIYVIGGDSIYHQMLPY--CSLGHVTKIDHEYVADSRFPDLDKEEWEVTGESEE-----QTYFDLEYTFIRYERK-
>tr|R6ZC02|R6ZC02_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:534 GN=BN699_01497 PE=4 SV=1
----MNLIVAVDENWAIGYQNELLVS-IPADHKFFRQETT-----G--KVVVLGRKTLETFP-QGLPLKNRTNIIMSTNPGYVK-DAT-VVHSTQELLKK
---Y------DEIYVVGGASVYRELLPY--CNVAHVTKIDHAYHADAYFPDLDKPEWRVTAESEE-----QTYFDITYHFLKYERA-
>tr|R9JIW9|R9JIW9_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 28-4 GN=C807_01669 PE=4 SV=1
----MNVIVAVDSHWGIGNKGELLVR-IPNDHKFFREETT-----G--KVVVLGRKTLETFP-QGLPLKNRTNIILSSNQDYVR-DAV-VVHNLEELMKK
---Y------EDIYIVGGDSVYRQLLPY--CDVAHVTRIDHRYEADAFFPDLDGEEWKITADSEE-----QTYFDIAYQFVKYERV-
>tr|E7GIU0|E7GIU0_CLOSY Dihydrofolate reductase OS=[Clostridium] symbiosum WAL-14163 GN=HMPREF9474_00833 PE=4 SV=1
----MQLIAAVDKNWAIGHKGQMLVA-IPADQKWFRQETM-----G--KIIVMGRKTLLTLP-GERPLDGRINLILTTDKSFLK-GAD-VCHSVEEVLKW
YKEE--R---EDVFIIGGQSVYEQFLPY--CDTAHITYIDYAYQADTYLVNLDKEGWIVTEESDE-----QTYFNLCYEFRKYKRP-
>tr|R7ANW8|R7ANW8_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:299 GN=BN593_02327 PE=4 SV=1
----MQLIAAVDKHWAIGKNGQMLAV-IPADQKLFRQETI-----G--KVVVMGRKTLESLP-GGRPLESRTNIVLTRDPAFVK-GAV-TVHSMEEALS-
----ELS---EDIFIIGGQTIYEQFLPY--CQEAHITFIDYEYNADTYMVNLEQ-GWIVTDCSDE-----QTYFDLCYEFRRYVRP-
>tr|C0CXS5|C0CXS5_9FIRM Dihydrofolate reductase OS=[Clostridium asparagiforme] DSM 15981 GN=folA PE=3 SV=1
----MNLIVAVDQNWAIGKDGRLLVN-IPADRQLFMKETT-----G--KTVVMGRKTLESLP-GGQPLGKRENIVLTRDENYVK-GAA-VCHSVEEALR-
----LLE---EDIFIIGGQSIYEQFLPY--CHTAHVTFVDYVYDADTLFPNLEQPDWRLAEESDE-----QTYFDLCYYFRRYERI-
>tr|D4C7R7|D4C7R7_9CLOT Dihydrofolate reductase OS=Clostridium sp. M62/1 GN=folA PE=4 SV=1
----MQLIAAVDKNWAIGRKGQMLVT-IPADQKLFRQETI-----G--KVVVMGRKTLAALP-GGRPLDSRTNIVLTRDPSLVK-GAT-AVHSVEEALE-
----KLS---EDIFIIGGQSIYEQFLPY--CGVAHITFIDYEYHADTYMVNLDK-GWRVTDVSDE-----QTYFDLCYEFRRYVRT-
>tr|D9R739|D9R739_CLOSW Dihydrofolate reductase OS=Clostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1) GN=Closa_2935 PE=3 SV=1
----MNIIVAVDKNWSIGNQGQLLVS-IPEDKKLFRDETM-----G--KVIVMGRKTLESLP-GKQPLYGRTNIVLTKNPDYVK-GAV-VCHSLTEAME-
----ELG---EDCFIIGGQSVYEQFLPY--CNTAHVTYIDYRYSADTYFPNLDQLSWEMVAESDE-----QTYFDLCYTFRMYQRK-
>tr|W4VBL9|W4VBL9_9FIRM Dihydrofolate reductase OS=[Clostridium] straminisolvens JCM 21531 GN=JCM21531_4216 PE=4 SV=1
----MKAIVAVDLNWGIGYKGNLLQR-IPEDMKFFKQMTL-----G--KVVVMGRKTFESLP-GKEPLKDRVNIILSKSGDFND-KII-VCRSMDELFKK
---Y------DDIFAIGGEEVYTQLLPY--CCEAYVTKFSNEYPADRYFPNLDEEGWKPVSLSEP-----KEYNDIWYSRLKYVNE-
>tr|T0I0P9|T0I0P9_9FIRM Dihydrofolate reductase OS=Dehalobacter sp. UNSWDHB GN=UNSWDHB_99 PE=4 SV=1
----MKAIVSVDQNWGIGYKGDLLLK-IPEDMKFFKQMTV-----G--KVVVMGRGTYESLP-GKEPLKDRTNIVLSTNRDFDE-RFI-ICHSLEDLLKE
---Y------DDICVIGGESLFQLLMPY--LNELYVTKIRHTFPADKHLRNVDEDNWKVESEGEL-----QTYNDIQYSVVKYVRK-
>tr|A0A0H3MY59|A0A0H3MY59_PEPDC Dihydrofolate reductase region OS=Peptoclostridium difficile (strain CD196) GN=CD196_0056 PE=4 SV=1
----MKVIVAVDLNWGIGYGGKLLQS-IPEDMKFFKEKTV-----G--NVVVMGRETFKSLP-GKKALKDRVNIVLTRSKSFDD-RLI-VCNSIDETLQK
---Y------DKIFIIGGETVYKQFLPY--CNELYVTKIQKTYEADRFFPNIDISNWDLIKESEV-----KEYNNIRYVFSTYINN-
>tr|A0A0L6JQX6|A0A0L6JQX6_9FIRM Dihydrofolate reductase region OS=Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933 GN=Bccel_3500 PE=4 SV=1
----MKAIVNVDLNWGIGCNGKLLVR-IPEDMRFFKQTTL-----G--KIVVMGRETFESLP-GGLPLIDRTNIILSRNNDYPS-GVI-KCSSIFDLNSQ
---Y------DDVFVIGGETVYKQLLPF--CSEAYVTKVQTKFGADKFFVNLDLDDWELIEESDA-----KAYNDINFRFCRYINK-
>tr|A0A0A2TKK9|A0A0A2TKK9_9FIRM Dihydrofolate reductase OS=Desulfosporosinus sp. Tol-M GN=JT05_03820 PE=4 SV=1
----MKAIAAVDLNWGIGYRGNLLER-IPEDMKFFKQMTI-----G--KVVIMGRKTFESLP-GKEPLKDRVNIVLSKNEGFNR-KVT-ICRTLDELFEK
---Y------DEVFVIGGESVYSQLLSS--CTEAYVTRIENKYPADKYFINLDKKAWKLKSESNL-----QNYGKIQYKFIKYSLS-
>tr|W2C0N3|W2C0N3_9FIRM Dihydrofolate reductase OS=Eubacterium nodatum ATCC 33099 GN=folA PE=3 SV=1
----MNLILAADENWAIGNKGDLLCH-LSGDLKYFKKTTT-----G--HTVIMGRKTLESLP-GKKGLSGRKNVVLTRDENFAE-GVD-TCHSIE---QV
L--K------DNAFVIGGAKVYEQLLPL--CDTCYITKIYGKFPADAYFVNMDEKEFRVTWQDEL-----MEDNGIKYRFMKYERQ-
>tr|R5YFD6|R5YFD6_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:197 GN=BN528_02305 PE=3 SV=1
----MNLIAAVDKNWAIGKNNELLVR-IPMDQKFFRETTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTHNPNYVN-DAI-VVHSLDELHE-
----ELK---EDVYVIGGEKIYEQLLDE--CDVAHITKIDYAYDADAYFPNLDEPEWEITADSDE-----QTYFDLEFYFYKYERR-
>tr|G2T118|G2T118_ROSHA Dihydrofolate reductase OS=Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183) GN=RHOM_04450 PE=3 SV=1
----MNLIAAVDQNWAIGNKNELLVR-IPADQKFFRETTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVLTHDHTYVP-GAV-VVHDMDELHE-
----ELK---EDIYVIGGETIYRQLLDE--CDVAHITKIDYAYDADAYFPNLDEPEWKITADSEE-----QTYFDLEYYFYRYERV-
>tr|R5U3U7|R5U3U7_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:50 GN=BN683_00886 PE=3 SV=1
----MNLIAAVDKNWAIGRNNKLLVS-IPDDMKFFRETTT-----G--KVVVMGRKTLESFP-GKKPLKNRVNIVLTGDRSYAD-GAV-IVHDMEELHE-
----ELK---EDIYVIGGESIYKQLLDE--CDVAHITKIDFAYEADAWFPNLDEEAWVVTADSEE-----QTYFDLEYHFYKYEKK-
>tr|R6P6D2|R6P6D2_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:45 GN=BN662_01171 PE=3 SV=1
----MNLIAAVDANWAIGYKNKLLVS-IPDDMKFFRQTTT-----G--KVVVMGRKTLESFP-NGQPLKNRVNIVLTGDKNYVK-DAI-VVHDLDELHK-
----ELE---EDVYVIGGESIYRQLLDE--CDVAHITKIDYAYDADAYFPNLDEEEWQITEDSDE-----QTYFDLEYYFLKYERI-
>tr|A0A0M6WVV4|A0A0M6WVV4_9FIRM Dihydrofolate reductase OS=Eubacterium rectale GN=T1815_28241 PE=3 SV=1
----MNLIAAVDNNWAIGKNNQLLVR-IPMDQKFFREMTT-----G--KVVVMGRKTLESFP-NSRPLKNRTNIVLTHNPSYVE-GAV-VVHSLDELHK-
----ELE---EDIYIIGGQKIYEQLVDE--CDVAHITKVDFEYDADAYFPNLDEPEWRITGDSEE-----QTYFDLEFYFLRYEKV-
>tr|R6B264|R6B264_9FIRM Dihydrofolate reductase OS=Roseburia intestinalis CAG:13 GN=BN484_01914 PE=3 SV=1
----MNLIVAADENWAIGNKNELLVR-IPADQKFFRETTM-----G--KVVVMGRKTLETFP-NGLPLMGRTNIVLTHDKKFVP-GAL-IVHDMEELHE-
----ELE---EDIYVIGGESVYRQLIDE--CDVAHVTKIDFAYDADAHFPDLDAPAWEITADSEE-----QTYFDLEYYFYRYERV-
>tr|E0RY65|E0RY65_BUTPB Dihydrofolate reductase FolA OS=Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) GN=folA PE=4 SV=1
----MKAIVAVDSNWAIGNKGQLLVS-IPADQKNFRNETI-----N--KTIVYGRKTLETFP-QRVVLPKRNNIILSAKKDYVK-DAA-VVHSRQELLSD
---L------DEVYIIGGESVYREFIDL--CDTAIVTFIDKEFEADTYFPNLDKPDWEMADESDE-----QVYFDLTYTYRTYKRI-
>tr|R9MZG1|R9MZG1_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 10-1 GN=C819_01704 PE=3 SV=1
----MNLIVAVDENWAIGNKNDLLIR-IPADHKMFRQETT-----G--KVVVLGRKTLETFP-QGLPLKNRTNIILSTNPSYVK-DAV-VVHSVEELLK-
----ELE---EDIYIIGGESIYRQMLPY--CDVAHVTKIDYAYTADAYFPDLDQPEWEITADSEE-----QTYFDIAYHFVKYERT-
>tr|R9KUT7|R9KUT7_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium A2 GN=C810_01574 PE=3 SV=1
----MNLIASADRNWAIGLNNKLLIR-IPEDMKFFQKTTT-----G--KVVVMGRKTLESLP-GGQPLKNRTNIVLTSNRGFVK-GAK-AVHSMEELLE-
----ELG---EDIYIIGGESVYRELLGL--CDVAHITKLEYEYEADAWFPNLEKKDWELTGSSEE-----QTYFDLEYYFLKYERK-
>tr|S0J328|S0J328_9FIRM Dihydrofolate reductase OS=Eubacterium sp. 14-2 GN=C805_00743 PE=3 SV=1
----MNLIAAVDKNWGIGMDNRLLVR-IPEDMKSFQKMTT-----G--KVVVVGRKTLETFP-GGQPLKNRTNIVLTQNREFVK-GAQ-VVHSMEELLE-
----ELK---QDIYIVGGESVYRQMVDL--CDVAHITKIDYEYAADAWFPNLDEEEWELTADSEE-----QTYFDLEYYFLKYEKK-
>tr|R9IZ89|R9IZ89_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 3-1 GN=C806_00186 PE=3 SV=1
----MNLIAAVDKNWAIGLNGKLLVK-IPEDMKFFQKVTT-----G--KVVVVGRKTLESFP-GGQPLKNRTNIVLTTNRNFVK-GAL-TIHSIEKLFE-
----ELK---EDIYIIGGESIYRQMVDL--CDVAYITKIDYEYLADAWFPRLDEEDWEQTGDSEE-----QTYFDLEYYFLRYERK-
>tr|R9KC85|R9KC85_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium COE1 GN=C809_03582 PE=4 SV=1
----MNIIAAVDRNWAIGNKNALLVK-IPRDQKLFLEMTQ-----G--KVVVMGRNTLESLP-QKQPLKNRVNIVLSSDKVYVK-GAT-VVHSLEELFL-
----ELK---EDVFVAGGETVYRQLLPY--CDTAHITKIDYAYEADAYFPRLDEPEWELAADSEE-----QTYFDLEYYFLQYQNT-
>tr|R7R4M1|R7R4M1_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:100 GN=BN450_01269 PE=4 SV=1
----MNIIAAVDTNWAIGNRGGLLVS-IPRDQKMFREMTM-----G--KVIVYGRKTLNTFP-QEQPLTGRTNIILSRDTSLIR-GAQ-VVHSIEELLES
---Y------RDVYIVGGESVYGQMLPY--CDTAHITKIDYNYQSDAYFPNLDMPEWHITADSDE-----LTYFDLEYTFTKYERI-
>tr|A0A0M6WSZ0|A0A0M6WSZ0_9FIRM Dihydrofolate reductase OS=Roseburia inulinivorans GN=RIL183_27471 PE=3 SV=1
----MNLIAAVDKNWAIGCKNKLLVS-IPADMKFFRETTT-----G--KVVVMGRKTLESFP-NGQPLKKRVNIVLTRDKNFAG-DAI-IVHSMEELRE-
----ELK---EDIYVIGGETIYKQLLDD--CDVAHITKIDYAFEADAYFPNLDEPEWKITQDSEE-----QTYFDLEYYFYKYEKN-
>tr|R9JUH5|R9JUH5_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium A4 GN=C804_01190 PE=3 SV=1
----MQLIAAVDNNWAIGFQNSLLVR-IPRDQQMFREMTE-----G--KVIVVGRKTFETFP-QKQPLKNRVNIILSRDQKYVK-GAE-VVHSMDELLKN
---Y------RDVFVAGGAGVYEQLLPY--CDTAHITKIDYTYQADAYCPRLDTADWHCTAESEE-----QTYFDIEYYFQKYERK-
>tr|R6CDX3|R6CDX3_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:56 GN=BN708_00840 PE=3 SV=1
----MNLIAAVDKNWAIGKNNELLVS-IPNDMKMFRQMTT-----G--KVVVMGRKTLESFP-NGLPLKNRVNIVLTKNQNYVK-GAI-IVHSVEEVLE-
----ELK---EDVYVIGGEQIYRQMLPY--CDTAHMTKIDHAYEADAYFPNLDEEEWKITATSDE-----QTYFDLEYYFVKYEKQ-
>tr|F7K4V5|F7K4V5_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 3_1_57FAA_CT1 GN=HMPREF0994_00884 PE=3 SV=1
----MNIIVAVDENWAIGCRGDLLVR-IPADHRMFRNETL-----G--KVVVLGRKTMDTFP-GGLPLQGRTNIVLTRNPDYVK-DAV-AVHSVEELLE-
----EVK---RDVYVIGGDSVYRLLLPY--CDTAHVTKIDRAYEADAYFPNLDEGEWEITADSEE-----QTYFDTTYHFVKYERK-
>tr|H1HRJ0|H1HRJ0_9FIRM Dihydrofolate reductase OS=Stomatobaculum longum GN=HMPREF9623_00210 PE=3 SV=1
----MILIAAVDSAWAIGKGGRLLVK-IPRDQKLFLEETL-----G--KTVIMGRKTFLDLP-GQQPLYGRRNIVLSRSPEFPK-GVT-VCHSIGEVLRE
---L------DEVFVCGGESIYRDFLPY--ADSAEITKIDYLYDGDRFFPNLDRSEWELTRESEE-----ETYFDLPFSFCRYERK-
>tr|N2AFW8|N2AFW8_9FIRM Uncharacterized protein OS=Eubacterium plexicaudatum ASF492 GN=C823_02980 PE=4 SV=1
----MNLIVSADENWGIGRNNQLLVR-IPDDLRLFRELTE-----G--KVVVMGRKTRESLP-NGI-LANRVNLVLTHDRHYAG-NAV-VVHSMDELHEP
---Y------DEVYVIGGGSVYSQLLDE--CSTAYVTKIEFAYAADAYAPNLDHPEWELIAESEE-----QTYFDLIYYFRKYKAK-
>tr|R5JUD2|R5JUD2_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:632 GN=BN743_00153 PE=4 SV=1
----MNAIVAVDNRWAIGNKGGLLVR-IPMDQKFFREVTI-----G--KVVVLGRKTLSTFP-NGLPLPGRTNIILSRNQNLVK-GAT-VVHSREELFKK
---Y------EDIYVIGGSMVYNLLIPY--CSLVHVTKIDYRYAADSYFPNLDEEEWEITGESDE-----NTYFDLEFTFYRYENK-
>tr|R5NN50|R5NN50_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:127 GN=BN482_02151 PE=4 SV=1
----MDLIVAVDNNWAIGNKGDLLVS-IPEDHKFFRQTTM-----G--NVVVLGRKTLAGFP-NGLPLAGRDNIILSTDPNYVR-GGT-VVHSKEELFKK
---Y------KEIFVIGGGQIYEMLLPY--CKYAHVTKINYDYAADTHFPNLDEENWEMIADSDE-----HTYFDLEFYFHKYENK-
>tr|A8SSS6|A8SSS6_9FIRM Dihydrofolate reductase OS=Coprococcus eutactus ATCC 27759 GN=folA PE=4 SV=1
----MKFIAAVDNNWAIGNKGSLLVR-ISEDQKNFRKETM-----G--HVVVLGRKTLEEFP-GGRPLKGRTNIILSTNPDYVQ-DAV-VVHSIDELFSE
---Y------DDIFIIGGQTVYDVLIPY--CDTGIVTKIDKSYEADAFIQNLDEDNWHVENERSG-----TEPNDVNITFVTYKNS-
>tr|A0A0C1TVS9|A0A0C1TVS9_9CLOT Dihydrofolate reductase family protein OS=Clostridium argentinense CDC 2741 GN=U732_812 PE=4 SV=1
----MNLIVAVDENFGIGNEGNLLTY-IPEDLEDFKKKTI-----G--KVVVMGRTTLESFP-NKAPLKSRINIILTRDKNYVE-NAI-VINFLETLFKS
---Y------EDIYVIGGESIYKKLEGY--CEFAYVTKINKTYKSDRHFFNIDEKKWVLENRGEII----TSCSGVSFNFNIYRNI-
>tr|R7IXI5|R7IXI5_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:303 GN=BN596_00684 PE=4 SV=1
----MKMIAAVDKNWGIGFENRLLFS-IPADMHRFRELTE-----G--NTVLMGRNTFLSLP-GQKALKNRKNIVLTHDGKFAA-PAV-IVTDMEQALTK
XXALEEI---GQVYVIGGGSVYRQFLPL--AEEILITYVDAEYQADTRFPNLDRDTWELVWQSER-----QTDFEAGYYFRTYRKR-
>tr|R6DK41|R6DK41_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:230 GN=BN547_02091 PE=4 SV=1
----MNLIVCVDAHWGIGNKGELLVS-IPGDKRMFKENTT-----G--KVVLGGRKTMEGLP-GGTTLKGRTNIVLTHQKDYFG-DAI-IVHSKEEALKE
---Y------EDIFIIGGEKVYRDFLPY--CKKAYVTKVDYRYEADVFFPNLDEDDWVMTHDSDE-----QTYYDLEYYFTIYQRK-
>tr|R5RL52|R5RL52_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:122 GN=BN479_01867 PE=4 SV=1
----MNLIACVDSNWAISNKGEILVS-IPADKKLFKELTD-----G--KVVVGDRRTMESIP-GGTTLGGRTNIILTSDQN---YNAK-IVHDMDEAMKN
---Y------EDIFVVGGEKVYKEFFPY--CERAYITKVDYEY-ADAYLENLEEDEWIMTHDSDEW----T-YYDLEYYFYQYKRR-
>tr|R6M4K4|R6M4K4_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:253 GN=BN565_01564 PE=4 SV=1
----MNLIACVDKNWAIGNKGELLVS-IPSDKKLFKELTD-----G--KVVIGGRKTMEAIP-GGTTLGGRTNIILTSDKKYYG-NAV-IVHSIDEALKK
---Y------EDIFVIGGEKVYKEFMPY--CSRAYITKVDYEYEADAYLENLEKDEWIMTHDSDE-----WTYYDLEYYFYQYKRK-
>tr|R6HAV7|R6HAV7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:137 GN=BN490_00140 PE=4 SV=1
----MDAIVAVYEDWGIGAEGTQPVA-LSADRRYFREKTQ-----N--AWVIVGRKTLGDFP-GGRPLPNRVNLVLTRGNP-IP-GAR-IVHSPGEALA-
----------KAVFVIGGASVYGAMLPF--CTRVYVTKVGACPPSDVFFPNLDQPDWVCADAGPQ-----CWEEGISYRFCVYTRC-
>tr|R6VE42|R6VE42_9FIRM Dihydrofolate reductase OS=Roseburia sp. CAG:380 GN=BN635_02289 PE=3 SV=1
----MRLIAAVDSNWAIGNKGELLVS-IPQDKKQFQELTM-----G--GVILGGRKTMEGLP-GGTTLKGRKNVILTRKQDYYS-DAV-IVHSIEEALKA
---Y------EQIYIIGGEQIYRQFLPY--CDRAYITKIDYHYEADTHFPNLDEPEWEMTHISDE-----QTYYDLEYYFTIYQKK-
>tr|I5ASV7|I5ASV7_EUBCE Dihydrofolate reductase OS=[Eubacterium] cellulosolvens 6 GN=EubceDRAFT1_1062 PE=3 SV=1
----MRAILCADKNWGIGKNNKLLVS-IPADMRFFRDTTS-----N--HVVVMGRKTLESFP-GGKPLKNRTNIVLSSNRNYVP-DAL-VVHSEQELLE-
----ELK---DEIYVIGGAAVYELMLPY--CDTVYVTRVEMEYDADTRFPDMDQPEWEITEESEE-----QTYFDVEYRFCTYRRK-
>tr|R5XUT6|R5XUT6_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. CAG:488 GN=BN680_01834 PE=4 SV=1
----MKLIAAVDNEWNIGNKGGLLFS-LPDDMKFFRTTTS-----G--KIVVMGRKTLESFP-GSKPLKNRVNIVLSRCNR-VD-GAE-FATSVDELLKA
---Y------DDIYVIGGAQIYSLLLPY--CDTALITHVDAVASADSKFPELKTDEWKITEQSDI-----HENNGLKFRFTTYKRI-
>tr|R6DZU3|R6DZU3_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. CAG:563 GN=BN710_00907 PE=4 SV=1
----MKLIAAVDNEWNIGNKGNLLFS-LPDDMKFFRTTTS-----G--KIVVMGRKTLESFP-GSKPLKNRINIVLSRSKH-VD-GAE-FVTGVDELLKG
---Y------GDVYVIGGAQIYSLLLPY--CDTALITHVDAVAIADSKFPELKDNEWTVTEQSDI-----HENNGIKFRFTTYKRI-
>tr|R7KCD1|R7KCD1_9FIRM Dihydrofolate reductase OS=Acidaminococcus sp. CAG:917 GN=BN810_00282 PE=4 SV=1
----MKAIVCVDKNWGIGKNNDLLFH-FKEDMRHFKEYTL-----G--NVVVMGSNTLISFP-DSKPLPDRTNIVLWPGGSRD---VV-LCQSLDEIFKN
---Y------EKIYILGGAMFYKTMLDY--CSEVIVTKVDADG-AQVFFENLDKEGWAVSDESEPM----TAECGLKYRFITYKNS-
>tr|R5J3B3|R5J3B3_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:7 GN=BN757_02699 PE=3 SV=1
----MNLIAAADENWGIGKNGGLLAH-ISGDMKYFRETTK-----G--KIVVMGRKTLESFP-GGKPLKNRVNIVLTGNKDFPE-GVV-ICHSVEETLKE
---Y------EDVFIIGGGMIYKAFLPW--CEKAYITHVYHTFEADTYLPDLEKAGWKLTSVSDRY----T-QPAMDYEFRIYERQ-
>tr|R6K884|R6K884_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:252 GN=BN564_01021 PE=4 SV=1
----MNIIALADKKWGIGKSGRVLVD-IPEDKKLFREETY-----G--KVVVMGRKTYESLP-NQSALTGRENIVLTNNVNYAK-DAK-ICHSVQEVLKA
----------EDVYIIGGGEIYEQFLPY--CDTAHITKVDYIYEADTHIMDFDKDDWKVTARSDE-----HTYFDICYEFVRYQRV-
>tr|A0A084JP81|A0A084JP81_9FIRM Dihydrofolate reductase OS=[Clostridium] celerecrescens GN=IO98_08525 PE=3 SV=1
----MNIIVAVDKNWSIGNQGQLLVS-IPEDKKLFREETM-----G--KVIVMGRKTLESLP-GKQPLYGRTNIVLTRNPDYVK-GAI-VCHSLPEVLK-
----ELS---EDCFVIGGQSIYEQFFPY--CDTAHVTYIDYLYSADTHFPNLDQPTWEMAAESDE-----QTYFDLCYTFRMYQRK-
>tr|A0A0F0CKF4|A0A0F0CKF4_9CLOT Dihydrofolate reductase OS=Clostridium sp. FS41 GN=dfrD PE=4 SV=1
----MNLIVAADRHWAIGKDGRVLVT-IPADQQTLMRETA-----G--KVVVMGRKTLESLP-GGQPLGNRKNLVLTRDEDYIK-GAH-VCHSLEEAMQA
----------NDIYIIGGQSIYEQFLPY--ADTVHVTRIDYTYDADTFFKNLENGDWGMTDEGDE-----QTYFDLCYTFQKFQRI-
>tr|R5GYF7|R5GYF7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:24 GN=BN555_02097 PE=3 SV=1
----MNLIVAVDKNWAIGNKGELLVR-IPADHKMFRQETT-----G--KVVVLGRKTMDTFP-GGQPLKNRDNIILSRNEAYQK-DAQ-VVHSVEELLE-
----AVK---KEVYVIGGSSVYEQLLPY--CDTAHVTKIDHAYEADAWFPNLDEPDWEITADSDE-----QYYFDLTYHFLKYERK-
>tr|G5IHW6|G5IHW6_9CLOT Dihydrofolate reductase OS=Hungatella hathewayi WAL-18680 GN=HMPREF9473_03089 PE=3 SV=1
----MNVIVAVDSHWAIGRGGQLLVN-IPADQKLFREETL-----S--KVIVMGRKTLESLP-AGQPLYGRTNIVLSRDMDYAK-GAI-VCHSVEETLQ-
----ELA---EDVFIIGGQSIYEQFLPY--CDTAHVTYIDYEYQADTWFPNLDKGDWVMDLESEE-----ETYFNLCYSFRRYVRR-
>tr|R7NEN9|R7NEN9_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:76 GN=BN774_01231 PE=4 SV=1
----MNLIALVDKKWGIANKGRELVD-IPEDKKLFREETY-----G--KVVIMGRKTLEALP-NQSALVGRKNIVLTRNKDYAK-DVC-LCHSVEDVLKN
----------KDVYVIGGGQIYKEFLPY--CDTAHITKVDYSYEADTYISDFDKKDWRITGQSDE-----HTYFDICYEFVRYERK-
>tr|A0A075KCH4|A0A075KCH4_9FIRM Dihydrofolate reductase region OS=Pelosinus sp. UFO1 GN=UFO1_0352 PE=4 SV=1
----MKLIVAVDQNWAIGYEGKLLEI-IPADMKYFKEKTI-----G--KVVVMGRATFESLP-GGRPLQDRINIVLTKSRVTCE-GMI-VCNSLTALFKK
---Y------EEIFVIGGESIYEQLIAY--CSEAYVTKIDKSYVANKSFPNLDAPDWKLVEESSL-----QNYKDINYRFIVYENK-
>tr|A3DES9|A3DES9_CLOTH Dihydrofolate reductase region OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4
----MKAIVAVDSNWGIGYKGNLLQR-IPEDMRFFRQMTL-----N--KVVVMGRKTFESLP-GKEPLKDRVNIILSKSENIKD-GII-ICRSVDGLFKK
---Y------DDIFVIGGEEVYTQLLPY--CSEAHVTKFNGAYSADRYFPNLDEEGWKLVCVGEP-----KEFNDIRYNRLKYVNE-
>tr|F0SXC6|F0SXC6_SYNGF Dihydrofolate reductase OS=Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR) GN=Sgly_0305 PE=4 SV=1
----MKALVAVDLNWGIGYRGNLLKR-IPEDMKLFKRLTL-----G--KVVIMGRATFESLP-GKEALKDRINIVLSKNDDYKA-NVT-VCHSLQELFQK
---Y------EDIFIIGGETIYSQLLPF--CSQAYITKIQNKYAADKYFPNIDQRSWKLVSQSDL-----KIYEDIQFFFTEYVKI-
>tr|A6BHY1|A6BHY1_9FIRM Dihydrofolate reductase OS=Dorea longicatena DSM 13814 GN=folA PE=3 SV=1
----MNLIVAVDSNWAIGKENKLLVS-IPQDMKFFRETTK-----G--KVVAMGRKTLESFP-GGQPLKNRVNVVLTTDKNYVK-DTV-IVHTIEEMVD-
----ELK---EDIFVIGGESIYRQLLPY--CTKAYITKIDHAYDADTYFPNLDEPEWEMTKISDE-----QTYFDLEYVFTIYERR-
>tr|C0B955|C0B955_9FIRM Dihydrofolate reductase OS=Coprococcus comes ATCC 27758 GN=folA PE=3 SV=1
----MNIIVNADKNWAIGKNNSLLVR-IPADMKYFRQMTE-----G--NIVVMGRKTLESFP-QGRPLANRVNIVISHNPDYVK-DAI-VVHSVEEAMQ-
----ECK---GEVFVIGGESIYRAMLPY--CNIAYVTRTDHVYEADTWFPDLEKPDWQKTAETDE-----QTYFDLEYVFAKYERI-
>tr|A0A0K9NGW5|A0A0K9NGW5_9FIRM Dihydrofolate reductase OS=Dorea sp. D27 GN=HMPREF0980_00557 PE=3 SV=1
----MNLIVAVDKNWAIGLGNKLLVS-IPQDMKFFRETTK-----G--KVVAMGRKTLESFP-GGQPLKNRVNVVMTTDKSYTN-GIV-LVHSLDEMLD-
----ELK---EDIYVIGGEAIYRQLLPY--CDRAYITRIDHAYDADTYFPNLDEPQWEMTKTSEE-----QTYFDLEYVFTVYERK-
>tr|G1WP44|G1WP44_9FIRM Dihydrofolate reductase OS=Dorea formicigenerans 4_6_53AFAA GN=HMPREF9457_00895 PE=3 SV=1
----MNLIVAVDKNWAIGMDNKLLVS-IPQDMKFFRETTK-----G--KVVAMGRKTLESFP-GGQPLKNRVNVVLTSDKKYVK-GTV-VVHSIDEMVE-
----ELK---EDIFVIGGESIYRQLLPY--CKTAYITKIDHAYQADTFFPDLDQPQWQMTKISDE-----QTYFDLEYVFTIYERV-
>tr|F7KQV8|F7KQV8_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 5_1_57FAA GN=HMPREF0993_01360 PE=3 SV=1
----MNLIVAVDKNWAIGNGNKLLVS-IPQDMKFFRETTK-----G--KVVAMGRKTLESFP-GGQPLKNRVNVVLTTDQNYAN-GAV-IVHTIEQMLA-
----ELK---EDIFVIGGESIYRQLLPY--CSKAYVTRIDHAYDADTHFPDLDVPQWEMTKISDE-----QTYFDLEYVFTIYERI-
>tr|R9MDF7|R9MDF7_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 3-2 GN=C818_02972 PE=3 SV=1
----MNLIVAVDRNWAIGKDNRLMHH-IPADMKYFREMTK-----G--GVVVMGRKTLESFP-QGQPLKNRVNIVISRRKDYVK-GAV-VVHSVEEAVE-
----ESK---GGIFVIGGESIYRAMLGY--CDTAYVTKIDHAFDADTYFPDLDAAEWEMTKISEE-----QTCFDLEYYFTVYERV-
>tr|R7N0H4|R7N0H4_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:95 GN=BN816_01056 PE=3 SV=1
----MNMIVAVDNNWAIGNHNELLVS-IPADMKFFRQETD-----G--KVVVMGRKTLESFP-NGMPLVNRVNIVLTENPDYVK-GAK-IVHSLAELQE-
----ELK---EDVYVIGGESVYRQLLPY--CDVVHATRIDMEYQADAHFPNLEKPEWIVTADSDE-----QTYFDIPYTFVKYERS-
>tr|F3B878|F3B878_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 2_1_46FAA GN=HMPREF9477_00148 PE=3 SV=1
----MNLIVAVDKNWAIGCGNRLLVS-IPADMKFFRETTT-----G--KVVVMGRKTLESFP-GGQPLKKRTNIVMTKDKNYVK-DAI-VVTSLEEVLE-
----ELK---EDIYVIGGESIYRQLLPH--CKTAYVTKIDHAYEADTYFPNLDEEDWSLTGISEE-----QTYFDLEYVFARYERV-
>tr|R5EB58|R5EB58_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:590 GN=BN724_00769 PE=4 SV=1
----MQLIVAVDENWAIGNGNKLLVR-IPEDQKFFRQTTM-----G--NVVVLGRKTLDEFP-NGLPLKGRKNIILSRDENYVQ-DAT-VVHSKEELLQQ
---Y------DQVFIIGGESIYRMMYEY--CDTAHVTKIQYAYQADKYFPDLDKQNWSIVGESDE-----QTYFDLEYYFYKYHNS-
>tr|F7V4D6|F7V4D6_CLOSS Putative uncharacterized protein OS=Clostridium sp. (strain SY8519) GN=CXIVA_16490 PE=4 SV=1
----MKLIAAADKNWGIGKNNQLLVS-IPEDMKFFRSTTM-----N--GVVVMGRRTLDSFP-GGRPLPRRVNIVLTAQQNFRE-GVI-VVHSLEELDR-
----VLA---DSIYIIGGESVYRQLKDR--CDTAYVTRIDYAYDADAWFPDLDAPDWEVTAVSEE-----QIYFDLIYHFCTYKRK-
>tr|I8TPG1|I8TPG1_9FIRM Dihydrofolate reductase region OS=Pelosinus fermentans JBW45 GN=JBW_04267 PE=4 SV=1
----MKLIVAVDEQWGIGCNGQLLVT-IPADMQHFKEKTK-----G--KVVVMGRGTFESLP-GQKPLQGRINVVLTKNIKIWE-GVT-LCHSLLQLFSL
---Y------EDIFIIGGESVYRQCLPY--CSEAYITKISKVHHADTCFPNLDKSEWQCIEESSV-----QSYKDITYRFATYKNL-
>tr|R5SLE9|R5SLE9_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:75 GN=BN771_00469 PE=4 SV=1
----WKLIACVDDHWGIGRQGQLLVD-IPADKKAFKAHTI-----G--KIVVGGRKTMEGLP-GARALPDRTNIVLSTDETYFE-GAQ-VLHSLQELKKQ
---Y------QEVYVIGGEEVYRLLLPY--CDTAYITKVHRQYEADAYFPNLDEQDWEICEQSFL-----QKQQNVIYEFITYQRI-
>tr|R7BS51|R7BS51_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:475 GN=BN674_01242 PE=4 SV=1
----MKTIFAVDNKWGLGKKNDLLFS-LKEDMRHFVAHTK-----G--KTVVMGSNTLLSFP-GGMPLKNRTNIVLNPNGTED-AGYI-LVKSLDELFKN
---Y------DQTYVIGGAMMYRTLLPY--CDTAYVTKVDADG-AEVFHENLDDPNWQLVEQSEPI----D-DNGYTIHFCTYKNN-
>tr|D4J9X4|D4J9X4_9FIRM Dihydrofolate reductase OS=Coprococcus catus GD/7 GN=CC1_24950 PE=3 SV=1
----MNLIVAVDKNWGIGYKNKLLNS-IPEDMKYFRETTT-----G--KVVVMGRKTLESFP-NGLPLKNRTNIVITGDHTYAK-DAI-IVHSIEEALE-
----ELK---NDIYVIGGESIYRQLLPY--CDVAHVTCMDYTYQADTWFPNLDEKDWVVAADSEE-----RTYFDLEYCFKMYVRK-
>tr|R7BDG8|R7BDG8_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:882 GN=BN803_01180 PE=4 SV=1
----MNVIAAVDANWAIGYKNELLVK-IPNDQKWFQKITT-----G--KVVVMGRKTMETFP-NGMPLKNRTNIVLTGDRALVK-DAE-LVYGIEELLD-
----KLK---EDVYVIGGESVYEELLPY--CDTAYITKIDYTYQADRYFPNLDNADWHIESESEE-----QTYFDLEYYFVKYVRG-
>tr|R6R0H9|R6R0H9_9FIRM Dihydrofolate reductase OS=Butyrivibrio sp. CAG:318 GN=BN606_01308 PE=3 SV=1
----MNLIAAVDRNWAIGYKNELLVR-IPEDQKWFRETTT-----G--KAVIMGRKTLESFP-NKSPLKNRLNVVITSDMNYVP-GAV-VVHSIDEAVE-
----AVR---DDVYVIGGESIYRQMLPL--CSTAHITKVDYAYQADAHFPDLDKEGWKITETSDE-----RTYFDIIYEFVKYERV-
>tr|A0A0K8J3S1|A0A0K8J3S1_9FIRM Dihydrofolate reductase OS=Herbinix sp. SD1D GN=SD1D_0457 PE=3 SV=1
----MNLIVAVDKNWAIGYKNKLLVR-IPADQRFFRNETI-----N--KAVIMGRKTLESFP-GGLPLKDRLNVVLTSDPNYVK-DAV-VVNSIEKALE-
----AVK---EDVYVIGGESIYRQMLPL--CDVAHVTKIDYAYQADAYFPNLDEEDWVITGESDE-----QTYYDIAYTFYKYERK-
>tr|L7VLL7|L7VLL7_CLOSH Dihydrofolate reductase FolA OS=Clostridium stercorarium subsp. stercorarium (strain ATCC 35414 / DSM 8532 / NCIMB 11754) GN=fo
----WIIIASADKNWGIGYKNKLLVK-IPEDMKHVSAKTT-----G--KVIVMGRKTLESFP-GGRPLPNRTNVVLTTNVGYVE-GAV-VVHSIQELMKD
---Y-------EIYVFGGESIYRQLMPY--CTKAYITRINKEFQADSFLPCLDEDGWKLIKKGRW-----QTREGIEYRFDEYIRS-
>tr|R5JIC4|R5JIC4_9FIRM Dihydrofolate reductase OS=Coprococcus sp. CAG:782 GN=BN781_00602 PE=3 SV=1
----MKMIAAVDRNWGIGYKGELLTR-ISSDLKNFKTLTI-----G--GTVILGRKTIEGFP-GARPLPGRKNIVLSRNKELIE-GAM-VVHSIEELKTG
---Q------DKVFVIGGASVYEQLLQY--CDGAVITKIDEEFIADAYLPVLDDDRWKMVDESEE-----YEEKGHRFKFCTYVNN-
>tr|A0A0H5SHU9|A0A0H5SHU9_9FIRM Dihydrofolate reductase OS=Herbinix hemicellulosilytica GN=HHT355_1867 PE=3 SV=1
----MNLIVAVDKNWAIGYKNNLLVR-IPADQRFFRSKTI-----N--KAIIMGRKTLESFP-QGKPLEDRLNVVITTKRDYVN-GAV-IVNSIEEALN-
----AVK---DDVYVIGGESIYRQMLPL--CDVAYVTKIDYSYIADTYFPNLDKDDWILTEESDE-----QTYHDLIYTFCRYERK-
>tr|R7D2Q7|R7D2Q7_9ACTN Dihydrofolate reductase OS=Collinsella sp. CAG:289 GN=BN589_01400 PE=4 SV=1
----LKAIVAVCDDWGIGANGDMVVS-NRADMRHFVSCTK-----G--HTVIMGRKTLESFP-GARPLKDRRNIVLTRDPLFCR-GAE-VVHTIEEALEP
---S------ELAWVVGGGKVYEQLLPY--CCEAEVTRNHCLRNSDTYFPNLDEPAWVVVSRSEM-----QGDAGVFYESTTYRRR-
>tr|U2U1N6|U2U1N6_9ACTN Dihydrofolate reductase OS=Coriobacteriaceae bacterium BV3Ac1 GN=folA PE=4 SV=1
----MRAIVAVCSDWGIGNKGQLLVN-NREDMRHFVRCTK-----G--GTVLMGRSTLDSFP-GGRALKERRNIVLTRQSDFRE-GVE-RAASVEEALSS
---E------NKVWVIGGSSVYRQLLPY--CSEVVVTKNDCLRPADAFFPNLDEPSWQLSEIEEG------TSEGIPFSFARYTRV-
>tr|A4E6S4|A4E6S4_9ACTN Dihydrofolate reductase OS=Collinsella aerofaciens ATCC 25986 GN=folA PE=4 SV=1
----LSAIVAVCDDWGIGCEGDMVV-S-RADMRHFVACTK-----G--CPVIMGRKTLLSFP-GGRPLKNRRNIVLTRDDDFAPGDVV-H--SIDEAL--
-------ADEPVAWVIGGGEVYRQFLPHCVEA--EVTHNHCVH-VDTYFPDL---AWEIAQRS--G----V-G--VDYEFVTYHRV-
>tr|R5ZA66|R5ZA66_9ACTN Dihydrofolate reductase OS=Collinsella sp. CAG:166 GN=BN511_00069 PE=4 SV=1
----LSAIVAVCDDWGIGCEGDMVVS-NRADMRHFVACTK-----G--CPVIMGRKTLLSFP-GGRPLKNRRNIVLTRDEGFSE-GVD-VVHSIDEALAD
---E------PVAWVLGGGEVYRQFLPY--CVEAEVTHNHCTHAVDTYFPDLDAPAWEIARRGGV-----AGDEGVDYEFVTYRRV-
>tr|C4F8V0|C4F8V0_9ACTN Dihydrofolate reductase OS=Collinsella intestinalis DSM 13280 GN=folA PE=4 SV=1
----LKAIVAVCDDWGIGRDGDMVVS-NRADMRHFVNKTK-----G--HPVIMGRKTLESFP-GGRPLKDRRNIVLTRDEAFRE-GVE-VVHSVDEALAD
---E------DVAWVIGGGAVYGQFLPY--CSEAEITHNHVAHEVDTHFPDLSQPAWYVAGRSDV-----QGDEGIMFEFVTYRRG-
>tr|B6GC06|B6GC06_9ACTN Dihydrofolate reductase OS=Collinsella stercoris DSM 13279 GN=folA PE=4 SV=1
----LKAIVAVCDDWGIGRDGDMVVS-NRADMRHFVACTK-----G--HPVIMGRKTLESFP-GGRPLKDRRNIVLTRDGSFRE-GFE-VVHSVDEARTD
---E------EVAWVIGGGAVYEQFLPY--CVEAEVTRNHVVHPADTFFPNLDEAAWKAAERQGE-----RGDAGLRYEFVTYRKV-
>tr|G1WGN9|G1WGN9_9ACTN Dihydrofolate reductase OS=Collinsella tanakaei YIT 12063 GN=HMPREF9452_00502 PE=4 SV=1
----LSAIVAVCDDWGIGRDGGMVVA-NKQDMRHFVSTTT-----G--HPVIMGRKTLESFP-GGRPLKNRLNIVLTRDPFFRE-GVE-VVHSVDAALCD
---Q------DEAWVIGGGQVYQQLLPY--CERAVVTKNHCLRAADAYFPNLDQEAWELVDETEP-----IGDEGVSFSFATYQRR-
>tr|D3R1R3|D3R1R3_MAGIU Dihydrofolate reductase OS=Mageeibacillus indolicus (strain UPII9-5) GN=folA PE=4 SV=1
----LGLIVGVDRHNAIGYRGELLFR-LPEDMKFFRQTTL-----G--TTIIMGRKTLAGFP-GGNPLPGRENWVLSRRVH-D-LNCR-FFADLEQVLRE
L--P------ASAWVVGGSEIYQLFLPY--CQIAYLSEFDCTAPADVFFPNLAHPAWQVVAKQPTI----HSRSGVDFQIVTYKNL-
>tr|R6NBB3|R6NBB3_9CLOT Dihydrofolate reductase region OS=Clostridium sp. CAG:413 GN=BN649_01375 PE=4 SV=1
----MKAIVCVDKNWGIGNADSLLFH-IPEDMAFFKRKTI-----G--NVVVMGLATFLSLP-GQKPLADRVNIVLSNKEDWAP-GVI-VCHSIDELFKR
---Y------NTVYLCGGASVYEQLLPY--CDTAYVTKVDASKPADKFFPNLDEADWVLAREKEE-----SEYNGLRYRFTTYKSI-
>tr|G5HR94|G5HR94_9FIRM Dihydrofolate reductase OS=[Clostridium] citroniae WAL-17108 GN=HMPREF9469_05106 PE=4 SV=1
----MNLIVAVDEAWGIGRDGGLLTH-LPGDMKYFRETTR-----G--KIVVMGRKTLESFP-DAKPLKNRVNIVLTQNRDYPE-GVT-VCHDVNETLKQ
---Y------EDIFIIGGGMIYGEFLPY--CKKAYVTCIHGIFQADTKFVDLDRKDWEWERVGEMQ------YNGLAYEFRIYTRR-
>tr|N9XEF7|N9XEF7_9CLOT Dihydrofolate reductase OS=Hungatella hathewayi 12489931 GN=HMPREF1093_03056 PE=3 SV=1
----MKAIVAVDEAWGIGKDGKLLTH-LPEDMKFFRTVTK-----G--KVVVMGRKTLQSFP-DAKPLKNRINIVLTSDDTMGE-GLI-VCRSVDDALKE
---Y------DDVYIIGGQSIYEQFLPY--CDTAYVTRMKRDFGADTWFVNLDSEGWEETETGEE-----KEYEGLHFAFCTYKNR-
>tr|N1ZGJ5|N1ZGJ5_9CLOT Dihydrofolate reductase OS=Clostridium sp. ASF356 GN=C820_02241 PE=3 SV=1
----MDIIVSVDENWGIGNNGQLLTK-ISADLKRFRKMTT-----N--NIIIMGRKTLESFP-EGKPLPNRINIVMTHSQEYCE-GVK-VCHNIQEVLSK
---E------KYVFIIGGESIYQQFLPY--CERAYVTKIYQTFVADTYFKNLDKYHWKLIEQLPM-----QEEEGIKYAYLTYENQ-
>tr|F1T5C6|F1T5C6_9ACTN Dihydrofolate reductase OS=Atopobium vaginae DSM 15829 GN=folA PE=4 SV=1
----IKAIVSVTQDWGIGYKGELLVP-NKADMQHFVRMTT-----G--ACVIMGSTTFETFP-KG-PLKNRRNIVLAQTHSYREGNYE-VYTSTQDALKP
---D------EDVWIIGGAYTYQQFLPY--CTEVVVTKNDCIR-ADAYFPNLDKDDWRITSTTEGG----ITSEGVHFLFVTYQHV-
>tr|E1L0E6|E1L0E6_9ACTN Dihydrofolate reductase OS=Atopobium vaginae PB189-T1-4 GN=folA PE=4 SV=1
----MKAIVSTTASWGIGYKGKLLIH-NPLDMKHFVSCTT-----G--HTVIMGTTTFESFP-KG-PLKHRRNIVLAFDAHYRAGNYE-VFTSIPDALDT
----------NDTWVIGGATVYKQLLDA--CSEVIVTKHDVNC-ADAYFPNLDDSDWHITETSQTH----YTQDGIAFRFVTYTHA-
>tr|A0A0I9PQZ6|A0A0I9PQZ6_KLEVA Putative dihydrofolate reductase OS=Klebsiella variicola GN=BN1200_1790048 PE=4 SV=1
----MKMIAAVGRNYEIGRGNELPW-R-PSELKLFRELTT-----N--ATVVMGRKTMESLK---RPLPERHNVVLTRSS-----GF--MPNGFYPANDV
---M---QLDGPVWVIGGAQIYSLFLP-H-VEELWLSHMGVDVPSDAHFPRQMM-NLGFVLTA--H----T-E--PGFQQIVYRRW-
>tr|M9HB46|M9HB46_ECOLX Dihydrofolate reductase family protein OS=Escherichia coli MP020980.2 GN=ECMP0209802_5267 PE=4 SV=1
----MKMIAAVGRNYEIGIANELPW-R-STDLKLFKRLTK-----N--ATVVMGRKTMESLK---RPLPERHNLVLTRSH-----GF--VPNGFYPAGDV
---L---RLPEPVWVIGGEQIYSLFMP-H-VEEIWLSHIGVDVPADAFFPASMM-NLGFVETA--Y----T-E--PGFSQIVYRRS-
>tr|A0A0K2MY06|A0A0K2MY06_CROSK Dihydrofolate reductase OS=Cronobacter sakazakii GN=AFK64_20355 PE=4 SV=1
----MKMIAAVGRNYEIGIGNDLPW-R-PTDLKLFKQLTR-----N--ATVVMGRKTMESLK---RPLSERHNLVLTRSR-----GY--LPNGFYPACDV
---L---ALPDPVWVIGGGQIYSVMMP-H-VEEIWLSHIGVDVPADAFFPAQMM-ALGFVDTA--Y----T-E--PGFLQIVYRRS-
>tr|A0A0P8DRM3|A0A0P8DRM3_KLEPN Dihydrofolate reductase OS=Klebsiella pneumoniae subsp. pneumoniae GN=AN662_11030 PE=4 SV=1
----MRMIAAVGRNFEIGRGNELPW-K-SADLRLFRELTH-----G--FTVIMGRKTAQSLG---KPLPGRRNVMLTRSQ-----GIE-VPQGIQSASRC
---L---REFPNAWVIGGSAVYEAMLS-H-VTEVWLSHINVEVPADAFFPFEAM-QMGFVDVV--N----E-S--PSFKQIVYRKM-
>tr|B6WB26|B6WB26_9FIRM Dihydrofolate reductase OS=Anaerococcus hydrogenalis DSM 7454 GN=folA PE=4 SV=1
----MKIILAVDENFGIGK-NKLLF-H-KKDLAHFKKTTL-----N--NIVIMGRKTYQSM-HG--ALPKRENIVLTRNKD-KLD--L-VFSDVDELLKE
---N---KKDREVFVIGGSQIVDLLLD-Y-CDEAIITKIYAK-KADTYLHNF--KNFGLI--E--E----S-N--TTYKYLVYRRI-
>tr|F0H1Y9|F0H1Y9_9FIRM Dihydrofolate reductase OS=Anaerococcus hydrogenalis ACS-025-V-Sch4 GN=folA PE=4 SV=1
----MKIILAVDENFGIGKDNKLLFH-FKKDLAHFKKTTL-----N--NIVIMGRKTYQSMN-G--ALPKRENLVLTRNKDLLD-DAL-VFNDVDKLLKE
N--K------REVFVIGGSQIVDLLLDY--CNGAIITKIYAKKDADTYLHNFDEINFKLVEESEE-----IIEDNTTYKYLVYRRI-
>tr|C7HSC0|C7HSC0_9FIRM Dihydrofolate reductase OS=Anaerococcus vaginalis ATCC 51170 GN=folA PE=4 SV=1
----MKIILAVDRYFGIGK-NKLLF-H-KKDLAHFKDLTL-----N--NIVIMGRKTYKSM-NG--ALPKRENIVLTRNKD-KLD--L-VFNSPQNILRE
---N---KNDREVFVIGGKEIVDLLLD-F-CDEAIITKIDAE-KADTFLHNF--KNFEIV--N--K----S-D--LKFNYITYRRK-
>tr|R7ALR6|R7ALR6_9FIRM Dihydrofolate reductase OS=Ruminococcus sp. CAG:379 GN=BN633_00500 PE=4 SV=1
----MNLIAAVDGAWHIGFGSRTAY-HLPQDLHHFRRLTY-----G--GVVVMGRKTFETLL---HPLEGRVNLVLSRCMQ--RPDIV-LCRELSLLPRS
-------MENRPVWVIGGAEIYRLLLP-F-CTCAHMTYTERIY-ADCTFPAPL--ALGWMLES-EE----P-E--FQFRV--YRNP-
>tr|E4XN72|E4XN72_OIKDI Uncharacterized protein OS=Oikopleura dioica GN=GSOID_T00015626001 PE=3 SV=1
----WNMILAADIKGGIGLRNDLPWR-IPQDLKHFQMLTK-----G--TVVVMGRNTWQSIPE---PLKGRVNVVITNTLES--EKCT-SLEA----INE
--------VNATKWIIGGATLYNRGLKENFIDEVYLTRIQGDYNCDTYVKDL---EVDYRLET--S----P-ESGIKYAFERYVKN-
>tr|A0A095XFZ4|A0A095XFZ4_9FIRM Dihydrofolate reductase OS=Clostridiales bacterium S5-A14a GN=HMPREF1635_04700 PE=3 SV=1
----MNIILAADRKWAIGKDNDLLIH-LPGDLKYFKKMTT-----G--KTVIMGRKTLESLP-GGKPLPNRRNIILTRSKDFVP-GAE-VFHSIEDVLKS
G-NL------DETFIIGGAEIYKQMMPH--CDKFYITKIDAELPADRYFVDLDQEDLEITWRAPAE------YQGTKYQYVLYERE-
>tr|R6HIZ3|R6HIZ3_9FIRM Dihydrofolate reductase OS=Oscillibacter sp. CAG:241 GN=BN557_00133 PE=4 SV=1
----MTAVVAVCENGGIGKDGALLFH-IREDLRRFRQLTL-----G--KTVVMGRKTLESLP-GGRGLPDRRNLVLTRDPELAP-GAE-VLRRLED----
----------EDAVVIGGESVYRQLLPR--CSTVYVTKIFAS-PADAFFPDLSRSGWTEAERSEM-----YTSGGVRFQYVTYRRR-
>tr|R6F0T7|R6F0T7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:145 GN=BN497_00027 PE=3 SV=1
----MKIIVAADKNWAIGREGELLCH-IPGDLKYFKEKTT-----G--KIVVMGRKTLESLP-GGRPLPNRTNIVLTKDKDFKE-GCV-IAGSIEEVLSD
---M------GEAMVMGGGLIYRQLLPY--CDGCYVTKIDAAFEADTYFPDLDAGDFRLIWESRPH------ENGVTYRFTEYERI-
>tr|G4D3T3|G4D3T3_9FIRM Dihydrofolate reductase OS=Peptoniphilus indolicus ATCC 29427 GN=folA PE=4 SV=1
----MFAIVNVDENWGIGADNDMLVH-LKSDLEFFKETTM-----G--KLILMGRKTYETLP-DKKPLPGRRNVILTRS-DIPE-GYE-VIHSPEKAMSE
---M------DDFAIIGGAEVYKMFLPY--CEKAIITKTHTAFEVEKYFPNLDEEDWEIESEGET-----VEDPQIDYHIVVYKNN-
>tr|R6IXX1|R6IXX1_9FIRM Dihydrofolate reductase region OS=Ruminococcus sp. CAG:177 GN=BN517_01021 PE=4 SV=1
----MKAIVCADINWGIGKGTGMLFH-IPADLKFLKEKTM-----G--STVIMGRTTFLSLP-GQKALPGRKNIVLTRSDGWAE-NVT-VCHGIDELAE-
----------ENVFLMGGEAVYNELIDS--CDEAYVTRVNADGKAEKFFPDLDAAGWRLVERSAA-----QESNGYVFTFDRYVKK-
>tr|R5GPI7|R5GPI7_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:786 GN=BN782_01394 PE=3 SV=1
----MKLILSADHDWAIGKDGALLAD-IPEDMKFFRETTQ-----G--ATVVMGRKTWDSLS--RKPLPGRDNCVISRSVK-LE-GAK-VFASVEELLDK
----------GEVFVIGGAEVYKELLPH--CDEAYITRIYENFHGDVFFEDIEHKAWEIAETSPV-----ISSECRNIRFFHYKRK-
>tr|R5L066|R5L066_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:115 GN=BN470_00845 PE=4 SV=1
----MTIILAADSDWAIGRDGGLLAH-IPEDMKFFRETTA-----N--STVVMGRKTWESIG--AKPLPGRVNCVISRSVK-LD-GAQ-VFGSVEEFLEK
----------GKVFVIGGGEIYRELLPY--CGEAFITRIYESFNGDVFFTDLEHRDWEIVETSPV-----MSSECRNIRSFHYIRK-
>tr|R6EPH2|R6EPH2_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:238 GN=BN553_00400 PE=4 SV=1
----MNLIAAADQNWGIGKDGGLLVH-LPGDLRYFREKTK-----G--KVVVMGRATLESLP-GGRPLPERTNIVLTSDTSFKE-GCI-IVHSMEKLMAK
---Y------DDVMIIGGEQVYMQLIRQ--CDRIFITKIFETFDADKHIMNVDRKHFEPVWESDV-----MEENGIQYQFVEYRRK-
>tr|C7H0N2|C7H0N2_9FIRM Dihydrofolate reductase OS=Eubacterium saphenum ATCC 49989 GN=folA PE=3 SV=1
----MNAIVVVDKNWCIGKDGGLLVH-LSKDLKYFKEKTI-----G--KTLIVGRKTLESFP-GGKPLPGRKTIVLTRNTSYAE-GAY-VCHSKQEVLKD
---L------ADVFVAGGGAIYKQFLND--VDKGFVTKICNEYSGDTFFPNLDEEDFALESEGETI------ENGVKFKFCIYNRI-
>tr|X8J701|X8J701_9FIRM Dihydrofolate reductase OS=Mogibacterium timidum ATCC 33093 GN=folA PE=4 SV=1
----MNLIVAVDEKWGIGCNNGLLAS-IPGDMQYFKEKTT-----D--GVVVMGRRTLESLP-KQRGLAKRVNYVLTSNREFAE-RCI-AVHSEEELFER
---Y------EHIFIIGGESIYKKLYRY--CDKCFVTKMHADLHADKFMVNLDESDFKETWKSEM-----HRENGIDYEFTLYERV-
>tr|R5FCI5|R5FCI5_9CLOT Dihydrofolate reductase OS=Clostridium bolteae CAG:59 GN=BN723_03302 PE=3 SV=1
----MNLIVAVDEKWGIGKDGGLLAH-LPEDMKYFRETTS-----G--RTVVMGRRTLESFP-GGKPLKNRVNMVLSRNEAYPE-GVQ-VYHKAEDVLKD
---C------DDVFIIGGGMIYREFLPY--CNKAYVTYIHRTFDVDTDFENLDQENWKLESVSDGR------HEGISFEFRIYRRV-
>tr|G4KXV7|G4KXV7_OSCVS Dihydrofolate reductase OS=Oscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20) GN=folA PE=3 SV=1
----MNAILSAAQDWAIGKDNHLLFH-LKEDMRRFRVLTT-----G--GTVIMGRRTLESLP-GEKPLPKRRNIIVTHDRQFRE-GAE-VAHSVDAALVD
---T------DDVWVMGGGSIYASMLSR--CKKVFLTRVDATVEADTFFPNLDKSCWKIVSQSEP-----IVEDGVSYRFFEYRNR-
>tr|U2QJQ9|U2QJQ9_9FIRM Dihydrofolate reductase (Fragment) OS=Oscillibacter sp. KLE 1745 GN=HMPREF1546_02294 PE=4 SV=1
----MNAIVVVDQNWAIGRDNDLLFS-LPTDMKRFRSLTL-----G--GTVILGRRTLDSFP-GGRPLPKRRNIVITHCPDFRE-GAE-TVSSLAAMRAG
---T------DQLWVIGGGSIYAALLSQ--CARAYVTRVDAAAEADSFFPNLDKPGWTVRAVSEP-----VTENGLTYR--------
>tr|D9PQH7|D9PQH7_FINMA Dihydrofolate reductase OS=Finegoldia magna ACS-171-V-Col3 GN=folA PE=4 SV=1
----MKVILAVDKNFAIGKDGDMLFS-IPEDMQRFKELTT-----G--NIVIMGRKTLESLP-DSKPLPNRTNIIITSKDL---DGML-CVKNEEELLKE
INPD------MTEYLIGGANTIESLIHL--VDEFVITYVDCEF-YDAKIRNLFEQDFYVSEESDIK----S-YEDLDYRYMVFKRK-
>tr|C7REN4|C7REN4_ANAPD Dihydrofolate reductase region OS=Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) GN=Apre_1626 PE=4 SV=1
----MKIILAVDKNWGIGKDGQMLFH-IRRDLKHFKSYTL-----G--NICIMGRKTYESMG-G--ALTHRENIVLSRNKDYAK-DAK-VFTDYRDVLRE
----------EEVFVIGGEKIVEIFLEY--CDEAIITKIYEKKDADSFLHNFDQDDWSLSEESDI-----MEENGVSFRYVRYRRK-
>tr|F0GV93|F0GV93_9FIRM Dihydrofolate reductase OS=Anaerococcus prevotii ACS-065-V-Col13 GN=folA PE=4 SV=1
----MKIILAVDKNWGIGKDGKMLYH-IKSDLKHFKDTTI-----N--NICIMGRKTYESMG-G--GLSSRENLVLSRNKDFIY-DGL-VFSNPEDVLKD
----------KEAFVIGGYKIVEMFLPY--CDEAIITKIDGEKKADTFLHNFDDHSWKVYEKSDI-----FTEDGVSFEYVTYRRV-
>tr|C2BF28|C2BF28_9FIRM Dihydrofolate reductase OS=Anaerococcus lactolyticus ATCC 51172 GN=folA PE=4 SV=1
----MKLILAVDKNWAIGR-NKMLY-D-KKDLNHFKEITT-----G--GLVIMGRKTFDSI-GF--ALPKRENIILTRDES-KRN--L-VFNNVSDVIN-
-------KSPKEAFVIGGAEICELFLA-Y-IDEAIITKIDSY-SADTFLHNF--SDFELV--E--E----S-G--KKIKFVRYKRK-
>tr|A0A095X0K3|A0A095X0K3_9FIRM Dihydrofolate reductase OS=Anaerococcus lactolyticus S7-1-13 GN=HMPREF1630_06020 PE=4 SV=1
----MKLILAVDKNWAIGR-NKMLY-N-KKDLNHFKETTT-----G--GLVIMGRKTFDSI-GF--ALPKRENIILTRDES-KRK--L-VFNNVSDVIN-
-------KSPKEAFVIGGAEICELLLD-H-IDEAIITKINAD-RADTFLHNF--NNFKPV--E--E----S-G--IKIKFVRYKRK-
>tr|C2CJZ1|C2CJZ1_9FIRM Dihydrofolate reductase OS=Anaerococcus tetradius ATCC 35098 GN=folA PE=4 SV=1
----MKIILAVDKNWGIGKNGKMLFH-IKKDLGHFKELTS-----G--NICIMGRKTYESMG-G--ALPNRENLILSRNKTYAP-DAL-VFNDYRDIFED
----------KEVFVIGGEKIVELFLDF--CDEAIITKIYAERLADSFLHNFDSDRWEVISKSDI-----MEENGVSFQYIVYRRI-
>tr|R6GIF4|R6GIF4_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:552 GN=BN704_00301 PE=4 SV=1
----MKLIVAVDRHWGIGKDNKLLFS-LKTDMAFFKKTTT-----G--KIVVMGKNTFLSFP-GG-PLKNRINVVLTKE--NQG--CI-CVKSMDELMSK
---Y------DEVYVIGGASMYRTMLPY--CETALITKVDAVGDADTYFPNLDLKNWELTQK-TE------AEDTFPIAFCEYKNK-
>tr|R5VU76|R5VU76_9DELT Dihydrofolate reductase OS=Corallococcus sp. CAG:1435 GN=BN495_00934 PE=4 SV=1
----MNTIVVVDKNWGIGKNNDLLFR-LKKDMKFFRETTT-----G--KVVVMGANTFLSFP-SG-ALPNRVNIVLDSSGAKDG--TI-SVDSVDKLNRN
---Y------NDIFVIGGASFYKLMLDR--CSVAYVTKVDADGDAEVFFPNLDQENWRLESQ-SEN----ISDGNYNISFCSYVND-
>tr|C0EV19|C0EV19_9FIRM Dihydrofolate reductase OS=[Eubacterium] hallii DSM 3353 GN=folA PE=4 SV=1
----MKLIAAADKNWAIGKDGELLVR-ISEDMKNFSAITT-----G--NVIVMGRKTLESFP-GGKPLPNRVNIVLTHEKDYGK-GAI-VVHSEEELWE-
----ELS---DSIFVTGGESIYRMLLPY--CDTAYITRLDYAYEADTWMPNLDKEHWSMVEKGEE-----RYCFDLIYHFTTYKNE-
>tr|E5VXL6|E5VXL6_9FIRM Dihydrofolate reductase OS=Anaerostipes sp. 3_2_56FAA GN=HMPREF1011_02741 PE=3 SV=1
----MNLIVNADKNWGIGRENQLLVH-IPNDMKMFRQTTT-----G--KVVVMGRKTLESFP-NGMPLPKRTNIVLTTDQDYGR-GAI-VVHSREELFE-
----ELK---EDIFIIGGESIYRMMLPY--CDTAYVTRLDYAYDADTYFPDLDAKEWEIVKESEE-----QTYFDLEYVFLKYQRR-
>tr|V1D8P9|V1D8P9_9FIRM Dihydrofolate reductase OS=Eubacterium brachy ATCC 33089 GN=HMPREF9089_01048 PE=4 SV=1
----MNAIVIVDKNWGIGRDNNLLVH-LPSDLKYFKEKTT-----G--KVIVIGRKTLESFP-GGRPLPNRLNIVLTGDENYND-HCT-VCVGEESLELK
---H------EDVFISGGERIYEQFIEK--CNVVYVTKMDAEFVADKHFPNLDEDLFQMTWESEP-----MKENGIRYRFTKYERC-
>tr|E6LPT6|E6LPT6_9FIRM Dihydrofolate reductase OS=Lachnoanaerobaculum saburreum DSM 3986 GN=folA PE=4 SV=1
----MNIIVSVDKRWGIGNKGKLLVS-IPRDKKLFREETT-----G--KVIIMGHNTLLSLP-GAKPLAGRKNIVLSNDKS---LGAT-VLNSVDACLKK
N-NI------NDVFVIGGESVYNDFLPY--CNIAHITYIDYEY-ADRHFLNMEKENWDLILETEEE----T-YFDIPYTFRLYKRN-
>tr|F3B119|F3B119_9FIRM Dihydrofolate reductase OS=Lachnospiraceae oral taxon 107 str. F0167 GN=HMPREF0491_00721 PE=4 SV=1
----MNLIVAVDKKWGIGNKGKLLVS-IPRDKKLFREETI-----G--KVIIMGHNTLLALP-GAQVLPERTNIVLSRDENFVK-GAI-VLNSVDSCIRE
------N---KDVFVIGGESIYKDFLPY--CDVAHVTYIDYEYEADRYFVNLDIKDWKLVLETEE-----ETYFDIPYTFRLYKRI-
>tr|K0XHU8|K0XHU8_9FIRM Uncharacterized protein OS=Lachnoanaerobaculum sp. OBRC5-5 GN=HMPREF1135_00982 PE=4 SV=1
----MNIIVSVDKKWGIGNKGKLLVS-IPKDMKLFREETV-----G--KVIIMGHNTLLSLP-GSQPLAGRENIVLSKDKN---LGAT-VVNSVESCLKE
N-NI------ENVFVIGGESVYRNFLPY--CNVAHVTYIDYEY-ADRHFLNLDAKEWSLLLETEEE----T-YFDIPYTFRMYKRV-
>tr|G5GER6|G5GER6_9FIRM Dihydrofolate reductase OS=Johnsonella ignava ATCC 51276 GN=HMPREF9333_00054 PE=4 SV=1
----MNIICAVDKNWAIGLNGNLLVS-IPQDKKYFRDETL-----G--KTIIMGRKTFEDLP-GVAALYGRKNIVLSRDKSFPE-GTI-VLRDLKECLKK
------E---EEVFIIGGESIYSQFLPY--CDIAHITYIDYEYKADRYMHNLDKSNWQLVLESDE-----ETYFDLVYYFRLYKRR-
>tr|R6MWR0|R6MWR0_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:41 GN=BN647_00581 PE=4 SV=1
----MKIIAAVDEKWGIGKGMNLLFR-ISEDMEFFKEKTM-----G--KTVVMGRKTLESFP-NAKPLKNRKNVVLTTD-KNKC--DG--TEIVHDIKGK
---Y------DDTFVIGGGEVYRQLLPY--CDSAYITKVFSDGNADVFIDNLDKEVWELGN-VSEK----RVENGISFVFCTYINK-
>tr|A0A0D0S947|A0A0D0S947_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium TWA4 GN=P261_01542 PE=3 SV=1
----LKLIAAVDHQWGIGKSGDLLVS-LPLDMKHFKEETM-----G--KTVIMGRKTLESFP-NHKPLPNRRNLVLTRNKNYLE-GIE-VFHDINDLL--
----------EDAYIIGGGEIYRQFLPY--CEEASITQIRHSFEADTFFPNLDESEWMLVDESNIM------EMGYHFTFRTYRRK-
>tr|R5AFS1|R5AFS1_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:102 GN=BN453_00751 PE=3 SV=1
----MDIIVAVDADWGIGKDGDLLQR-ISADMKYFREKTT-----G--NVLVMGRKTLESFP-NKKPLPNRVNIVLTKNKDYAE-GVV-LCHDLAELPEN
---Y------KQVFVAGGGTVYAQLLPQ--CERAYVTKIYQTYPADTAFPNLDEPDWELEEKGEM-----QEEKGVRFSFDVYKKR-
>tr|R5FWW4|R5FWW4_9FIRM Dihydrofolate reductase OS=Faecalibacterium sp. CAG:1138 GN=BN468_01151 PE=4 SV=1
----MKAIVAVDKKWGIGKNNGLLFQ-IAEDMRFFRQQTL-----G--KTVVMGRKTLESFP-NGKPLKNRKNVVLGNP-KNEG--IV-SVKNFEELKSG
---E------SDVYVIGGGSVYNLLLPY--CDSVLVTKVKADGDAEVFFPNLDEENFFVSSDSGDV----ATESGYTIRFVTYENK-
>tr|R6TWV3|R6TWV3_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:272 GN=BN580_02195 PE=4 SV=1
----MFIIASADRNYGIGNRGGLLCR-VSADMKNFRALTE-----G--KTVILGSKTLATFP-GGRPLKNRRNIIMSRRPEYVE-GAE-VVHSLEELL-P
----------SDAAVIGGEGIYRLLLPY--CDRAVITEFDAEFPADAFLPKIPDPGWEKESESGT-----FSSPGTAWRIVTYTNR-
>tr|V2YG26|V2YG26_9FIRM Uncharacterized protein OS=Firmicutes bacterium ASF500 GN=N510_01345 PE=4 SV=1
----MNLIVAVDQNWAIGRDGDQLVY-ISADLKHFKALTT-----G--HTVILGRKTLATFP-GGRPLKGRRNLILSRTPGFPQ-GAE-VFSDLDSLL--
----------EDAFVLGGASVYHALLDR--CDTAYVTKIGRAFPADCWFPDLDAPQWRVEEESEP-----QEENGLRFRYVTYRRQ-
>tr|R5H9G7|R5H9G7_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:114 GN=BN469_01251 PE=4 SV=1
----MKLIVAVDACWAIGKDGDQLCY-IPPDLKRFQRLTT-----G--HPVLLGRKTLATFP-GGRPLKNRRNLILSTDPAFPA-GGE-VFATLKAAL--
----------ADTFVIGGASVYRQALAY--CDTAYVTQIHRAFPADCYFPNLAAPAWEAVETEGP-----YRYEDLAYTYVTYRRR-
>tr|F4XA26|F4XA26_9FIRM Dihydrofolate reductase OS=Ruminococcaceae bacterium D16 GN=HMPREF0866_00141 PE=3 SV=1
----MNLIVAVDQNWAIGKDGDQLVY-LKEDLKRFRTLTS-----G--HTVILGRKTLATFP-GGRPLKNRRNLILSRNPQFAE-GAE-VFSSVEELV--
----------GDAFVIGGASVYEQLLPY--CDTAYVTKIHAGFPADTYFPNLDQGEWEVSEESESL------QDGISYHYVTYSRI-
>tr|U2DF68|U2DF68_9CLOT Dihydrofolate reductase OS=Clostridium sp. ATCC BAA-442 GN=HMPREF0239_00583 PE=4 SV=1
----MNLIAAVDLNWAIGRDGDQLCY-IPADLKRFQALTT-----G--HPVILGRKTLATFP-GGRPLKNRRNLILSRDSAFPE-GAE-VFRSLEALR--
----------ADSFVIGGASVYAALLDW--CDTAYITKIGRAWEADAFFPDLDAPDWEMAEEGEP-----QEHAGIPFRYVTYRRR-
>tr|S5VM46|S5VM46_9CAUD Dihydrofolate reductase OS=Pseudomonas phage PaBG GN=PaBG_00040 PE=3 SV=1
----VILIAAVAANDCIGDKGKLPWH-IPEELALFKKITG-----T--SPLICGRRTFESMPR---VWQTRAPCVLTQDVTSV-NLFT-VSDDLN--VVQ
----------GRVFIIGGKSLYEAAFEGKHVDEAIITHLTYSYVGDTFMPPL---FHQVEQIA--E----H-------TTHRYEAL-
>tr|A0A0H1S438|A0A0H1S438_9MOLU Dihydrofolate reductase DHFR OS=Mycoplasmataceae bacterium RC_NB112A GN=MRERC_3c089 PE=3 SV=1
----------MDHNYLIGKGNKLPW-KIPAEMKYFSQITS-----G--NTVLMGSKTFESIG---KPLKNRQNIVITKNPE-RNWSLI-FSDNLNEILKN
-------NPKNHVFVIGGREIYQQTYF-Y-ADYYYVSVVKGVY-GNIYFPFPTW-NFKLIKKE--E----F-----EFIAYIYQVP-
>tr|A0A0K1F568|A0A0K1F568_9ACTN Dihydrofolate reductase OS=Olsenella sp. oral taxon 807 GN=ADJ70_12490 PE=4 SV=1
----MDAIVSVTRDWAIGNRGRLLVR-NKADMRRFATLTQ-----G--CAILMGRATFESLP-KG-PLKGRRNIVVSHDRGYRDGGYE-VYVTPGDALGD
---R------ARAWLIGGESLYRTLLPR--CERVLVTKSDVVV-ADAFFPDLDEPGWQLVERSFGG----VTDEGIAFEYVTYATR-
>tr|U2T583|U2T583_9ACTN Dihydrofolate reductase OS=Olsenella profusa F0195 GN=folA PE=4 SV=1
----MRAIVSVTNDWGIGRDGRLLVP-NKADMHHFVELTR-----G--CTVLMGRMTFEGLP-KG-PLRGRRNVIVSHNGTYRTGGYE-VCTSFEDALAG
---D------DRVWLIGGESLYRALLPA--CSEVEVTKNDTCI-ADAFFPDLDEAAWEVVRRSSGG----TTDDGVTFEYVTYRRG-
>tr|G5F4F0|G5F4F0_9ACTN Dihydrofolate reductase OS=Olsenella sp. oral taxon 809 str. F0356 GN=HMPREF1008_01310 PE=4 SV=1
----MNAIVSVTPSWGIGRDGALLVR-NRADMRRFVELTM-----G--GTVIMGRKTLQSFP-GG-PLRGRRNVVLTRGTGGPE-GVE-VASGIEEALAD
---T------DEVWLIGGQSVYQELLPW--CERAYVTMNYVEAEADAWFPRLDDPGWRIESREEG------TAGGVPFEYLTYRQL-
>tr|Z4WXH8|Z4WXH8_9ACTN Dihydrofolate reductase OS=Atopobium sp. BS2 GN=folA PE=4 SV=1
----MNAIVSVTHDWGIGCDGDLLIP-NKADMKHFVEHTR-----G--CTVVMGRKTLESFP-GG-PLKGRRNIVISRNADYVE-GVE-VVSSAEEALED
---E------EKVWLIGGASIYRTLLDK--CSYAYVTKHDTVVDADTYFPNLDEPAWEVCNEEDG------TPEGIAFKFVTYKHV-
>tr|S3ANP9|S3ANP9_9ACTN Dihydrofolate reductase OS=Atopobium sp. oral taxon 199 str. F0494 GN=HMPREF1527_00251 PE=4 SV=1
----MNAIVSVTHNWGIGCDGDLLIP-NKADMKYFVEHTR-----G--CTVIMGRRTFESFP-GG-PLKGRRNIVITRDLSWHD-GVE-VVSSPAAALAS
---E------EKVWLIGGASVYRAMLPN--CTFAFVTKHDIEVPADSYFPDLDTPAWRVVAIEKG------TPKGVAFEFVTYEQV-
>tr|N2BIV8|N2BIV8_9ACTN Uncharacterized protein OS=Atopobium minutum 10063974 GN=HMPREF1091_00676 PE=4 SV=1
----MRAIVAVTSNWAIGCKGRLLID-NKADMQHFVRHTR-----G--GTVIMGRTTLESFP-GARPLPKRRNIVLTRNTGWCV-GVE-VVHSVSEALAT
---D------NEVWCIGGMSVYEQMLPH--CSDVIVTKHDCIRDADAYFPNLDTPHWQLVATQKG------TPDGITFDFVQYHRV-
>tr|E1QZV3|E1QZV3_OLSUV Dihydrofolate reductase region OS=Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / VPI D76D-27C) GN=Olsu_
----MNAIVSVTSDWGIGNNGRLLVR-NRADMHRFVELTR-----G--GTVLMGRTTFESFP-KGPLVG-RRNVVITHDAHYRAGGYE-VYTTPEDALVG
---E------GKVWLIGGESVYRALLPR--CSRAYVTKNDTVVEADAYFPNLDEPAWQIADSQPGG----VTPEGVSFSFVTYERR-
>tr|F2N7N9|F2N7N9_CORGP Dihydrofolate reductase region OS=Coriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2) GN=Corgl_0818 PE=4
----LFAIVSVCRDWGIGCAGDMVVR-NRVDMRHFVSLTR-----G--HAVIMGRKTLESLP-GGAPLRDRRNIVLTHDETFRE-GVT-TVCTAAAAIAE
---E------DEAWLIGGAAVYRLLLPF--CSRAFVTKHDCVRTCDAYFPDLDVPAWSLECAGTR-----AGDEGLGYSFDVYVRS-
>tr|R7AK02|R7AK02_9ACTN Dihydrofolate reductase OS=Collinsella sp. CAG:398 GN=BN642_01072 PE=4 SV=1
--------MAVCDDWGIGRDGDMLVA-NRADMRHFVRCTK-----G--HAVIMGRKTLESFP-GGRPLKDRRNIVLTRDASFRE-GVE-VVHSLDEALAN
---E------GEAWVIGGAEVYRQLLPL--CAEVVVTKNHVTHAADAFFPNLDDPRWRVSATDGG-----YGDAGVAFEFVTYERR-
>tr|S2JGD7|S2JGD7_MUCC1 Uncharacterized protein OS=Mucor circinelloides f. circinelloides (strain 1006PhL) GN=HMPREF1544_11685 PE=3 SV=1
----PFIFMA-LENGGIGY-NGLPW-S--GDWKFFEETTSKAYFGEPDTVMIMGRQSYESRPM-RVPLFYRYNVIVSRN-----P-IAELV--LDDALGR
---I----EEGRIFVLGGEQIYRQSIL-PEC--VLLTNVY----CDTFIPKI--EVFR-LATH--E-----T---FQYEFVLHIRR-
>tr|D2E8H0|D2E8H0_ANHV1 Dihydrofolate reductase OS=Anguillid herpesvirus 1 (isolate Anguilla anguilla/Netherlands/500138/1998) GN=AngHV1_ORF119 PE=4 SV
----MELIVARNLNGAIGRGGRLLYK-LPKDLQRFRDLTQ-----D--QIIVMGRKTFETLPR-----PRRRHVVLSKSAPAINIEGV-WIRNLPDCLLP
-------TARSKLFIIGGAEVYNLFWKH--CSVLHITKVVASEPKPRHEE-E---SWAVSDSQ--L----R-GFGI--IFETWRKK-
>tr|U1QL95|U1QL95_9EURY Dihydrofolate reductase OS=Halonotius sp. J07HN4 GN=J07HN4v3_00121 PE=3 SV=1
----LVSVAAIADNRVIGD-GGLPWPS-PADKRQYRERI-A----D--HPVILGRVTFESMLD---DLPGSAQIVLSRSER-FDE--Y-HASGVDGAVNS
---L----SADTAYVIGGAVIYDLFQP-Y-LDRMVLSRVPGEYEGDAFYPEWDE-AW---TDT-TE----H-R--LE----KWVRV-
>tr|U1QEY2|U1QEY2_9EURY Dihydrofolate reductase OS=Halonotius sp. J07HN4 GN=J07HN4v3_00935 PE=3 SV=1
----LVSVAALADNRVIGD-GELPWPS-PADKEQYRDRI-A----D--DPVILGRVTFESMRN---NLPGSAQIVLSRSEQ-FEE--H-HAAGVDDAIED
---L----GAAQAYVIGGAVIYDLFQP-H-VDRMVLSRVPGEYEGDAYYPAWDD-AW---EST-TE----Y-R--LE----EWVRN-
>tr|U1PGB9|U1PGB9_9EURY Dihydrofolate reductase OS=Haloquadratum walsbyi J07HQW1 GN=J07HQW1_01213 PE=4 SV=1
----FTSVAALADNHVIGH-GDLPWES-PADKQQYRERV-T----G--SPVILGRRTYESMRM---DLPGRRQIVLSRQKR-FGA--I-HAVDIDSAIRQ
---T----GANTVYILGGAAIYSLFQP-H-IDRMVLTRVPGVYQGDSYYPEWNE-AW---ISI-ED----Y-T--LE----EWTRT-
>tr|Q18J41|Q18J41_HALWD Dihydrofolate reductase OS=Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) GN=folA2 PE=4 SV=1
----FTSVAALADNYVIGR-GDLPWES-PADKQQYRERV-S----G--FPVILGRRTYESMRS---DLPGRRQIVLSQQKQ-FHI--T-HAPDIDSAIKQ
---T----DTKTVYILGGAAIYSLFQS-H-IDRMVLTRVPGIYQGDSYYPEWND-VW---IST-ED----Y-T--LE----EWTRQ-
>tr|U1PWV3|U1PWV3_9EURY Dihydrofolate reductase OS=Haloquadratum walsbyi J07HQW2 GN=J07HQW2_03390 PE=4 SV=1
----FTSVAALADNHVIGH-GDLPWES-PADKQQYRDRV-S----G--SPVVIGRRTYESMRV---NLPGCQQIVLSRQKE-FSP--T-HAPDIDSAIRQ
---T----GAETVYILGGAAIYSLFQP-H-IDRMVLTRVPGVYEGDSYYPEWDE-AW---IST-RE----Y-T--LQ----KWTRK-
>tr|M0CZZ4|M0CZZ4_9EURY Dihydrofolate reductase OS=Halosimplex carlsbadense 2-9-1 GN=C475_04266 PE=4 SV=1
----LISVAAVADNGVIGDDDEVPW-HLPEDKKQYRERVA-----G--SPTIFGRRTYE-MF---DEPPGSAYVVLS-RSE-YDDNAH-HASSVDEAAVE
---S---LGADRAYVLGGAGIYALFQP-H-LDGMVLTRVPGEY-GDTHYPEWDE-DWRLVETE--E----Y------FTVETWERR-
>tr|V4XG32|V4XG32_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HB70 GN=A07HB70_00658 PE=4 SV=1
----LVSVAALSENRVIGR-GELPWPS-PADRAQYRALV-A----D--APVVLGRRTFDSMRD---DLPGRAQVVVSRSRD-VDA--R-VAGGVSDALSA
-------VGADVAYVLGGGVTYHLFQP-H-VSRMVLSHVPGAYEGDSTFPAWDE-AW---ARE-EP----R-T--LR----EWVRR-
>tr|M0I764|M0I764_9EURY Dihydrofolate reductase OS=Haloferax mucosum ATCC BAA-1512 GN=C440_13284 PE=4 SV=1
----LVSVAALAENHTIGR-GELPWPS-PEDKKQYRARI-A----D--DPVILGRRTFESMLD---DLPGSDQIVLSRSEQ-FDV--H-HARNVEEAIES
---L----GAETAYVIGGAAIYELFQP-H-LDRMVLSRVPGEYDGDTYYPAWST-DW---ESE-TP----Y-T--LQ----EWVRT-
>tr|M0FYN3|M0FYN3_9EURY Dihydrofolate reductase OS=Haloferax sp. ATCC BAA-645 GN=C459_07730 PE=3 SV=1
----LVSVAALAENRVIGR-GELPWPS-PADKEQYRNRI-A----D--DPVVLGRTTFESMRD---DLPGSAQIVMSRSER-FSV--H-RAASVEEAVES
---L----GAETAYVIGGAAIYALFQP-H-LDRMVLSRVPGEYEGDTYYPEWDD-EW---DAE-TD----Y-T--LQ----EWVRS-
>tr|M0CCX1|M0CCX1_9EURY Dihydrofolate reductase OS=Halosimplex carlsbadense 2-9-1 GN=C475_19223 PE=3 SV=1
----LVTVAAVADNGVIGR-GELPWPS-PEDRRQYRERI-A----D--HPVILGRRTFESMRE---DLPGTAQIVVSRSDR-YDV--R-HAAGVDDAVHA
---L----GASRAYVIGGGGIYALFQP-Y-VDRMVLSRIPGEYEGDTYFPEWDA-EW---VDA-VD----Y-T--LE----EWVRE-
>tr|M1XP40|M1XP40_NATM8 Dihydrofolate reductase OS=Natronomonas moolapensis (strain DSM 18674 / JCM 14361 / 8.8.11) GN=folA2 PE=4 SV=1
----IVSVAAVAENGVIGR-GELPWES-PVDKRQYRERV-A----D--GPVILGRRTFESMRE---DLPGRAQVVLSRTER-YNV--R-HAADVDAALAS
---L----GYPSVYVLGGGEVYELLQP-H-VDRMALSRVHGSYDGDSHYPEWDA-EW---ERE-TP----Y-T--LE----EWRRI-
>tr|I3R495|I3R495_HALMT Dihydrofolate reductase OS=Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) GN=
----LVSVAALAENHVIGRDGELPW-PIPEDKKQYRERIA-----N--DPVILGRRTFESML---DDLPGSTQIVLS-RSE-FEVTAE-HASSVDEAIAE
---S---MDAETVYVIGGEAIYELFQP-H-LDRMVLSRIPGEY-GDTFYPEWET-DWELKSET--P----H------FTLQEWIRT-
>tr|V4XRV8|V4XRV8_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HR60 GN=A07HR60_01326 PE=4 SV=1
----LVSVAAVGDDLAIGA-GGLPWDS-PRDKAQYRRRV-A----G--SIVILGRRTFESMQG---DLPGVIQIVLSRSAR-YDV--H-HADGVESALAT
---R----DEDTAYVLGGAEIYELFQP-H-LDRMVLSRVTGSYDGDRYYPQWKS-EW---VAE-ES----Y-A--VE----TWERQ-
>tr|A0A0N0U980|A0A0N0U980_9EURY Dihydrofolate reductase OS=Haloarcula sp. SL3 GN=AMS69_11285 PE=3 SV=1
----LVLVVAADENNVIGL-GGVPW-H-PEDVRQYKARI-A----G--HPIILGRRTFESMKP----IPDCYTVVLTDDSR-ANS--E-YATTPQIAVAR
A-GN---DSPPITYVIGGEAVYDLFLP-F-ASRVFLSRIHERNEGDRYFPDMG--EW---LSR-ES----Y-D--VI----EYKQA-
>tr|V5TLA5|V5TLA5_HALHI Dihydrofolate reductase OS=Haloarcula hispanica N601 GN=HISP_07650 PE=3 SV=1
----LVLVVAADENNVIGL-GGVPW-H-PEDVRQYKDRI-A----G--HPVILGRRTFDSMDS----LTDCYTVVLTDDSR-ADS--E-YATTPQIAVAR
A-GA---DSPPVTYVIGGEAVYDLFLP-F-AGRIFLSRIHERNEGDRYFPDLG--EW---LSR-EF----H-D--VI----EYEQA-
>tr|M0EUQ1|M0EUQ1_9EURY Dihydrofolate reductase OS=Halorubrum coriense DSM 10284 GN=C464_01943 PE=4 SV=1
----LVSVAALAENRVIGK-GEVPWSH-EADVRQYRERV-V----E--SPVILGRRTFDSMRG---DLPGSRQIVVSRSVD-VDE--R-VASGVEEALRD
LVKR---EGDETVYVLGGGGIYELFQP-H-LDGMALSHVEGAFDGDTYYPEWDG-EW---TEE-TA----Y-T--LR----EWVRR-
>tr|A0A059X0N2|A0A059X0N2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRFIVAIDDKNGLADDHGIPWP-KPSDLRLFRDSTK-----H--TIVMMGYKTYQEFDH---PLSDRRNLVATHTAGPLQAGFE-AVND--KFL--
--------STEDIWVIGGAGLFATTLDL--ADELLITYIKGDYNCTKFFPDY-K-AKTETQT----------G--VEFYFTTWKRK-
>tr|A0A059WY65|A0A059WY65_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IKFIAAIDDKRGIAKAGKIPW-D-PSDRKYFREHVK-----P--GPVVMGWNTFESNG-Q-KPYGDGKNTVITR-RD-APG-VA-VVHDLEAFF--
-------NLDEDIWVAGGGQVFTAALP-Y-ATTLYVTRVKGDY-CDVFFPEFEN--FVLSHEE--P------G--VQYQYQVWQRK-
>tr|A0A059WRZ4|A0A059WRZ4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRAIAAIDEKRGLAR-GDIPW-K-PEDVKYYRDKTE-----H--STIIMGRDTYEGF---AKPLVNRRNVVISRTLQ-VREGFE-LVHDVDAFL--
-------QATEDIWNIGGAGIFESTLG-Y-CDELYLTHVAGDFNCDRFFPEY----YKLVTRS--P----D-G--HRFYYAVYAKN-
>tr|A0A059XDY3|A0A059XDY3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRAIAAIDDKRGLAAPNHVPW-Y-PEDLAEFKSKTL-----N--STVVMGRSTYDTLQ---KPLPNRRNVVASRVNQ-RPG-FE-LITDLPGFL--
-------DAEGDIWVIGGGEIYKTALP-Y-CDELHITHVKGDF-CDVFFPEYEP--FELVGST--P------G--YDFNFAVYKQI-
>tr|A0A059WHZ4|A0A059WHZ4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRAIAAIDDKLGIAAEGHIPW-DIPIEVQRFKELTM-----G--GIVVMGRRTYGTLT---NPLPGRRNIVVSHNLS-VREGFE-LVTDIEDF-LN
-------TAAGDVWIIGGAEMYAAVLH-R-CDELYLTQVRGNY-CDRFFPNFE--RFKLIDES---------G--YRFTYATYTRI-
>tr|A0A059X6S0|A0A059X6S0_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRAIAAIDDKRGIAQAGNIPW-E-PTDLKHFQQLTK-----E--HIVLMGRHTYELFN---QPLPNRQNVVVSRSLD-RPG-FQ-LEPDAEAFL--
-------QTTDDVWIIGGAALYAAGLQ-Y-CDELYLTHVRGDF-CDTFFPEYAD--FTLCDQS--P------G--FDFHWAIYKKN-
>tr|M7P5E3|M7P5E3_PEWBP Dihydrofolate reductase OS=Peanut witches'-broom phytoplasma NTU2011 GN=folA PE=4 SV=1
----ISLIAAVDGNFLIGNGEKLPWH-YPRDLAFFKKKVN-----D--QVILVGLRTYQSLCY-NKKFPFKSIYLATTSLDIP-ASIQ-KVND--IFLR-
--------TSKSIIVIGGRQIYQLALPY--VDVLYLTYILRRFVGNIYFPYLNL-EYTVIE---------------ELIFATYFKK-
>tr|R4RZR3|R4RZR3_PHYAS Dihydrofolate reductase OS=Strawberry lethal yellows phytoplasma (CPA) str. NZSb11 GN=dfrA PE=3 SV=1
----INLITAFDSNYLIGSDNKLPW-HYPQDLHFFKKTTL-----N--QEVLMGHQTYLSLKSKDKPFNFKKTYVAARN-----KGCE-VVFDLLTFLLI
-------QKKSHLFVIGGRQIYQQSLP-F-VDNLYITHILNRH-GNVYFPPVN--DFQLIQKT--I----Q-----QLIFAFYKRK-
>tr|B3QZX1|B3QZX1_PHYMT Dihydrofolate reductase OS=Phytoplasma mali (strain AT) GN=folA PE=3 SV=1
----ISLITALDPNFLIGNCNMLPW-HYPQDLKFFKKMTN-----N--KNVLMGYCTYKSLKKKNKNFLFQKTYVASFD-----QDAI-VINNLFNFL--
---------QDEIIIIGGSQIYKQTLP-Y-INILYVTHILTRF-GDSFFPFVN--KYKIVSKK--I----Y-----ELIFVEYHKI-
>tr|U4KL33|U4KL33_9MOLU Dihydrofolate reductase OS=Acholeplasma palmae GN=folA PE=4 SV=1
----IILIWAMDTNFLIGKDNKLPW-RYKEDLKYFKATVE-----N--KTVLMGDMTYLSLKGKDKPLPYGKIYVASKN-----NNVT-IIDNLEYFL--
---------KEDIYVIGGRTIYQVALP-Y-ADRLYITHILKRH-GNIYFPKFD--QYKVIQKR--Y----S-----ELIFSIYEKK-
>tr|A6QKP0|A6QKP0_ONYPH Dihydrofolate reductase OS=Onion yellows phytoplasma OY-W GN=folA PE=3 SV=1
----INLITAFDGNYLIGKDNKLPW-HYSQDLQYFKKITL-----N--QNVLMGYETYKSLKSKNKPFNFKKTYVASLK-----HNCT-VVSDLQSFMA-
---------AQDIFIIGGGKIYQQTLP-W-VTTLYITHILQRH-GNVFFPKID--QYQLIQKE--I----H-----QLIFAIYQKK-
>tr|U6DZY7|U6DZY7_9MOLU Dihydrofolate reductase OS=Candidatus Phytoplasma solani GN=folA PE=3 SV=1
----ISLITAFDSNYLIGFDNKLPW-HYPDDLQYFKKMTF-----N--QEVLMGYQTYLSLKSKDKPFYFKKTYVASLQ-----KNCE-VVFNLANFLAT
-------NSNINIFIIGGRQIYRQALP-Y-TKFLYITHILNRY-GNVYFPKID--SFQLMQKT--I----Q-----QLIFTLYQRK-
>tr|I0IE92|I0IE92_PHYMF Dihydrofolate reductase OS=Phycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01) GN=folA PE=3 SV=1
----IHLIYARSLDHCIGRDGGLPW-R-PADFRHFKRTTL-----G--HPIVMGRKTYGDH---QSVLPGRTNVVLSRDPG-G-AGIV-VRHDLEAALG-
-------GGR-LAFVIGGAGVFSAAFPR--AEAVIETIVREVP-GDVRVEAF---GWRSEKIL--E----H-A--FAFEV--WERK-
>tr|A0A0R2HD46|A0A0R2HD46_9FIRM Uncharacterized protein OS=Kandleria vitulina DSM 20405 GN=IV49_GL001454 PE=4 SV=1
----ITIIVAADQDLLIGKKNGMPW-SNSEDLKHFKKTTL-----N--HTVLFGMNTFKAMG--SRPLPKRKTIILTRSDF-S-D-VE-VRHQLEDVIKD
R--G------EDLFICGGANIYKQALPL--ADEILLSRIPGKHTGETYFPSD---GYTCVE-----------P--FTFTLEVYRRV-
>tr|M2Q2B6|M2Q2B6_9FIRM Uncharacterized protein OS=Eggerthia catenaformis OT 569 = DSM 20559 GN=HMPREF9943_00608 PE=4 SV=1
----ITIIVACDNENLIGQSNGMPW-NNKEDLKHYKETTI-----H--HTIVMGRKTYEAIG---RPLPKRHVIVCSRK-----SRIE-VRDNLEDVIRE
-------KN-EDLYICGGANIYKQALP-L-SDCILLSRIPGIH-GETYFPDFK--GYLLKEIK--P----F-----TFNLEIYQRG-
>tr|R5QSJ2|R5QSJ2_9FIRM Dihydrofolate reductase OS=Coprobacillus sp. CAG:235 GN=BN550_00538 PE=4 SV=1
----ISIIVATDDDLLIGKSNGMPW-HNKEDLQHFKKTTL-----H--QTILMGKTTYMAIG---RPLPHRKTIVVTRG-----ERVE-VRHDLVETIKN
-------KK-EDLFICGGASIYKQALP-Y-VDELMISRIPGKH-GETYFPSFD--NFQLEKET--Q----M-----TFVLQIYKKG-
>tr|A0A0J8YYW8|A0A0J8YYW8_9FIRM Dihydrofolate reductase OS=Coprobacillus sp. 8_1_38FAA GN=HMPREF0979_01803 PE=4 SV=1
----ISIIVATDDDLLIGKKNGMPW-HNKEDLQHFKQTTI-----N--KTILMGKTTYLAIG---RPLPNRKTIVVTKS-----GRVE-VRNNLIEVIKD
-------RK-EDLYISGGASIYKQALP-Y-VDELIISRIPGKH-GETYFPSFE--NFQLEKET--Q----M-----TFVLQIYKKG-
>tr|A0A059X546|A0A059X546_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=4 SV=1
--------AAMDSKRGIGK-NDLLF-K-PEDFVRMKELTD-----G--HPIIMGRRTFESV---GRILPNRYNVVITRDPD-EFPRGT-IVNSLENAIKK
---A---PGSEEIIIFGGGQIFTEAVEKGLVDVLHLTIVDGDFGADTFFPEY----FTKTLHE--E----S-E--YHYKFLDLAKP-
>tr|U2Q7P3|U2Q7P3_9FUSO Dihydrofolate reductase OS=Leptotrichia sp. oral taxon 879 str. F0557 GN=HMPREF1552_00726 PE=4 SV=1
----YSIVVAVGKNNEIGKNNQLLW-HIPEDLKKFKEITT-----G--KTVVMGRHTYESIGK---PLPNRKNIVFSKSFF-ITEKLK-ICNDFYKFVEN
--------VEEEIFIIGGEQIYKKSLELEIVSKIYMSYIDFSDTADAYFPKIDL--WITLTEE---------G--WKFCI--YEKI-
>tr|U2RKZ2|U2RKZ2_9FUSO Dihydrofolate reductase OS=Leptotrichia wadei F0279 GN=HMPREF9015_01178 PE=4 SV=1
----YSIVVAVGKNNEIGK-NQLLW-H-PEDLKNFKKITT-----R--KTVIMGRNTYKSI-G--RALPNRTNIVLSRNKK-ENE--E-FFNDFQKVIKD
--------LPEEIFIIGGGEIYKKSLELGIVKRIYMSRVDFSDDADAYFPEI---KWVTLTEE--N----Y-D--GW-KFCIYEKI-
>tr|C7N8V9|C7N8V9_LEPBD Dihydrofolate reductase OS=Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b) GN=Lebu_068
----FSLIVAVGENNEIGK-NQLLW-H-PEDLKNFKKITM-----G--KTVIMGKNTYKSI-G--KPLPNRKNIVLSRNKK-ENE--E-LCDNLQKIIKN
--------SEEEIFIIGGGEIYKKAFEMKIVKRIYMSHVNFSDKADTYFPKI---KWVVITKE--N----Y-D--GW-RFCIYEKI-
>tr|D0VXF2|D0VXF2_9CAUD Putative dihydrofolate reductase OS=Bacillus phage phiNIT1 GN=dfrP PE=4 SV=1
----VALIAAMGLNLEIGA-NRLLW-D-KEDMNWFRQKTK-----N--KVVVMGRKTYESI-G--KPLKGRVNVVLTHNKE-DPH----VRHNLED---F
E--F---RNELEIMVIGGETIYNQFFP-Y-ANRIYLTQVEKTYEADAFFPEF---IWNRYFYQ--D----G-G--IKYNFSVYKKR-
>tr|A0A0G0TW29|A0A0G0TW29_9BACT Dihydrofolate reductase OS=Microgenomates (Levybacteria) bacterium GW2011_GWC1_40_19 GN=UT87_C0007G0060 PE=3 SV=1
----ISIIAAMDEKRGIGK-NDLLF-K-PEDFERMKKLTM-----G--HPLVMGRKTFESL---GRKLPGRSHIVITHDPS--LEPDK-TVSSLEEGLKS
---K---DGSDEIFIFGGGQIFQEAIEKGLVDRLYLTIVQGDFGADTFFPDY----FAKVISE--T----K-K--YKYTFLDLEKS-
>tr|A0A0G0WLP4|A0A0G0WLP4_9BACT Dihydrofolate reductase FolA OS=Microgenomates (Levybacteria) bacterium GW2011_GWA2_40_8 GN=UU21_C0014G0025 PE=4 SV=1
----ISIIAALDEKRGIGK-NDLLF-R-PEDFERMKNLTM-----G--HPLVMGRKTFESL---GRKLPGRYHVVITSNLS--LEANV-VVDSLEEGLKN
---A---PGSEEIFIFGGGQIFKEAMEKDLVNSLYLTLVEGDYGADTFFPDY----FDKVLKE--T----S-E--YKYKFLDLEKS-
>tr|A0A0G0JFI4|A0A0G0JFI4_9BACT Dihydrofolate reductase OS=Microgenomates bacterium GW2011_GWA2_37_6 GN=US51_C0003G0004 PE=4 SV=1
----ISIVAAIDEKRGLGKNNDLLF-RIPQDFKRMQKLTK-----G--HSIIMGRRTFE---SVGRVLPDRTNIVISRNPS---DNLI-FCSSLEEALQG
---K---PGAEEIFIFGGGQVFKEVIEKNLVDCLYLTIVEGDY-ADTFFPDYS------RI-I--K----E-N--YKFNFLTLQK--
>tr|A0A059X7Q7|A0A059X7Q7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----ISIVAAMDTKRGIGK-NDLLF-K-PEDFVRMKKLTE-----G--HPIIMGRRTFESI---GRILPNRYNIVITRDPD-EFPRGT-IVGSLEEAVKR
---A---PGSEEIIIFGGGQIFTEAVEKGLVDILHLTIVDGDFGADTFFPDY----FTKILDE--E----S-E--YHYRFVDLAKD-
>tr|A0A059X8W3|A0A059X8W3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LSAIVAVSDNDVMAKDGKIPW-FVRGEQLIFKRLTT-----G--HPIIMGRKTFETPKTKPMLLPDRLNIVVTRNRH-V-PGGV-VVNSLKQALAV
-------KQADEAFVIGGAEIFELAMP-H-VTKLYLTRVHTTIEGDKFFR-FNQ--WNQTHKE--F----Y-P--YDFEFQVWERS-
>tr|A0A0K1W169|A0A0K1W169_9MOLU Dihydrofolate reductase OS=Spiroplasma litorale GN=dfrA PE=3 SV=1
----ISLIWAQTKNNVIGN-NKLPW-D-KSEMKHFVDYTK-----G--KTVLMGRNTFESLK--IKPLPKRENIVITSRPM---KQLW-KSDNLTKVLKN
--------IEKELVVIGGAQIYTEALK-F-ADKLVVSIIKEDY-GNVYFPNW---DFNLIEEK--E----N----DEFIIQIYERK-
>tr|H7DK44|H7DK44_9CLOT Dihydrofolate reductase OS=Candidatus Arthromitus sp. SFB-5 GN=SFB5_276G8 PE=4 SV=1
----IKLIACIDKYSSLGINNNLIYF-IKEDLKIFKEKTI-----N--NIVVMGRKTFNSLNN---PLPNRENIIISRNLCNPKDSYT-VFN----DILK
--------TPKDIFIIGGSKIYKYFTDF--YDEIHLTMIKDKYTKVYPINQSVK-NFKLIDQ----------EYD--IFFIKIYQR-
>tr|G2IGJ9|G2IGJ9_9CLOT Dihydrofolate reductase OS=Candidatus Arthromitus sp. SFB-rat-Yit GN=RATSFB_0365 PE=4 SV=1
----IKLIACIDKYNSLGINNELIYR-IKEDLKIFKEKTI-----G--NIIVMGRKTFNSLDN---PLSNRKNIIISRNLCNPDNSYI-VFN----DILK
--------TSKDIFIIGGNEIYKHFTPF--YDEIHLTIIKNEYTKLYPVNQSVK-NFKLINQ----------EYN--MFFINIYKK-
>tr|R4U377|R4U377_9MOLU Dihydrofolate reductase OS=Spiroplasma chrysopicola DF-1 GN=dfrA PE=3 SV=1
----IKLLWAMDENHLIGADNKLPW-HLKEELAHFKATTL-----G--KTILFGRKTYEGIG---KKLPNRKIVLLTHQKD-IDDDVE-VINNFDNIIS-
-------NPTNEILICGGKKVYEDFLP-Y-ADMLIISEIKGQYAGDTYFPGFD-TAFQQISEV--V----K------PGFIIKEYI-
>tr|W7IUZ0|W7IUZ0_9PSEU Dihydrofolate reductase OS=Actinokineospora spheciospongiae GN=UO65_0494 PE=3 SV=1
--------MAADENDVIGRDNALPW-H-PVDLARFKRLTM-----G--HALVAGRHTHESILDLGKPLPGRFTAVVTGKPD-AGAGAA-SQPSCRSALRS
V-EA---AQRDEVFVIGGAQVYGQLLDD--VDRVYLTRVHQHL-GDVAMPAG---AFELTGGE---------D--SRCSFLTYDRR-
>tr|C3JYD2|C3JYD2_PSEFS Putative dihydrofolate reductase OS=Pseudomonas fluorescens (strain SBW25) GN=PFLU_3870 PE=4 SV=1
-------MAGMGRNRSIGKAGGLLR-M-PDDMRRFAAKTI-----G--KPVIMGRKTFESVIASGRPLADRPNIVLSRNPA-HEQA-V-VCRSLASALA-
-------YHPEEIHIGGGPELYDQVIDR--VDRLYLTLFNDDHEGEARFPSF---FIEV-CHH---------G--LAYEWVDYVRR-
>tr|A0A024B139|A0A024B139_9CAUD Dihydrofolate reductase OS=Bacillus phage Hoody T PE=4 SV=1
----ISLIAAVDEKGGIGK-NELLV-K-KEDFDWFVEKTI-----H--KPVIMGSKTHLSI-G--KFLKNRVNIVLTRNKD-KPL----VYHDIHS---N
D--F---KDEKELMVIGGSSIYEQFAP-M-ANRFYITELGKSF-ADSYFPEF---IYKCFYKR--K----G-G--FEYYFRVYKKV-
>tr|C5RC79|C5RC79_WEIPA Dihydrofolate reductase OS=Weissella paramesenteroides ATCC 33313 GN=folA PE=4 SV=1
----KNLIWAQTLDGTIAIDGHIPW-H-KADLQFFKQSTI-----H--EAALMGRHTMASFH--GRPLPERLNLVLTRNHD-VPEGFQ-KVYSVAEAED-
-------NANLKLQVIGGKPIYESFMD-T-ADTLYVTYLQTDFS-DVKMAPVDL-VWQGEVID--Q----G-D--YDWRLVKYTRQ-
>tr|A0A0R2HAY2|A0A0R2HAY2_WEIVI Dihydrofolate reductase OS=Weissella viridescens GN=IV50_GL000349 PE=4 SV=1
----ITLIWAQTNDGTIALNRQIPW-H-KDDLKIFKALTL-----E--KVVVMGRHTMESFN--GRPLPERMNLVLTHDES-VPMKV----YSIESAL-A
-------ESGTDLAIIGGKPVYEAFMD-L-ASDLYVTYLDTDFTGDVKMPVV---EWQGTEYA--H----G-D--YDYSVMHYTRR-
>tr|A0A0R2F4K5|A0A0R2F4K5_WEICO Dihydrofolate reductase region OS=Weissella confusa GN=IV69_GL001615 PE=4 SV=1
----KILIWAQTNNGTIALNGSIPW-R-KTDMKFFKEQTI-----H--QVALMGRNTMLSFG--GRALPERINMVLTHDEN-VPAGFD-KVYSMDEAED-
-------ENNMKLAVIGGKAIYDSYLP-V-ADILYVTYLDTDFM-DVLMAPVDK-IWLGEEIA--S----G-Q--YDWRIVKYTRR-
>tr|A0A075TVV0|A0A075TVV0_9LACT Dihydrofolate reductase type 3 OS=Weissella ceti GN=dhfrIII PE=4 SV=1
----VNLIWAETNDGTIALDGGIPW-Q-KSDLKFFKEETI-----D--QVIVMGRNTMNSFR--GRPLPKRVNLVLTRDET-VPEGFV-KVYDVETAMD-
-------DAGAKLQIIGGKPIYESFMA-V-ADHLYVTYLDTDFR-DVHMDKVDK-KWRGEEIA--S----G-D--FDYTIVKYSRF-
>tr|A0A0R2JEH7|A0A0R2JEH7_9LACT Dihydrofolate reductase OS=Weissella kandleri GN=IV73_GL000278 PE=4 SV=1
----KVLIWAQTLDGTIALNGQIPW-H-RSDIRFFAQTTR-----G--QVVVMGRHTMESMH--GRALPGRTNLVLTHDAN-VPAGFE-RILSMAEAEQ-
-------QKQSDLMIIGGKPIYESYLP-T-ADQLLVTYLQSDLQ-DVKMDPVNL-QWQRTIVQ--T----G-D--YAYEIVNYQRN-
>tr|A0A0R2G7D3|A0A0R2G7D3_9LACT Dihydrofolate reductase region OS=Weissella halotolerans DSM 20190 GN=IV68_GL000165 PE=4 SV=1
----VKLIWAQTNNGTIALEQAIPW-H-STDMRFFKKATL-----H--QVVVMGRHTMASLH--GRPLPDRLNLVLTHDEQ-LPAGFE-RIMQPEEALQ-
-------ALGCDLAVIGGKAIYETYLP-L-ADHLYVTYLDTDFN-DTHMAPVDK-QWLGRELA--H----G-D--YAYQIMDYQRR-
>tr|A0A0R2JQH7|A0A0R2JQH7_9LACT Dihydrofolate reductase OS=Weissella minor GN=IV67_GL000248 PE=4 SV=1
----ISLVWAQTNDGTIAVNNQIPW-H-KDDMLLFKQATL-----N--KVIVMGRHTMESFN--GRPLPKRLNLVLTHDES-VPEKV----HSVEEAI-A
-------AANLDLAVIGGKPIYESFMP-V-ADKLVVTYLDTDLTGDVKMPKV---VWKGTPIA--Q----G-D--YDYEALEYELR-
>tr|F8HYM5|F8HYM5_WEIKK Dihydrofolate reductase OS=Weissella koreensis (strain KACC 15510) GN=WKK_06245 PE=4 SV=1
----KVLIWAQTKDGTIAKDGSIPW-H-QGDMKFFAQKTK-----N--QVVLMGRNTMMSLH--GQPLPNRINLVLTHQKD-VPVGFK-KVYSIETAED-
-------EEQKQLMVIGGKGIYDSYLP-I-ADRLLVTYLATDYH-DVMLDPIE--AWKKELLT--E----G-D--YAYQIWNYYRP-
>tr|G0UIK7|G0UIK7_9LACT Dihydrofolate reductase OS=Weissella thailandensis fsh4-2 GN=WT2_01650 PE=4 SV=1
----QNLIWAQTLDGTIAIDGKVPW-H-KADLHFFKQATV-----H--EVALMGRHTMASFH--GRPLPDRLNVVLTHNQG-VPDGFR-KVYSIAEAED-
-------DAGLKLQVIGGKPIYESFMA-T-ADVLYVTYLQTDLS-DVKMSPVDA-VWQGEIID--Q----G-D--YDWQLMKYTRR-
>tr|A0A0H5BX84|A0A0H5BX84_9ENTR Dihydrofolate reductase OS=Candidatus Westeberhardia cardiocondylae GN=folA PE=3 SV=1
----ISIISAMSKNHVIGI-NYIPW-Y-PNDLKWFKHNTI-----N--KPIIMGNNTYKSI-N-KIPLPNRLNIILTKKIH-TKKNTI-F---KKTAL-I
I--P---KKEKEIMIIGGNQIYNIFFK-Q-AHRLYLTHVNIIIKGNVFFPKY---NWFSIYKK--F----S-L--YDCFFEILQRH-
>tr|A0A0E4FIA4|A0A0E4FIA4_HALJP Dihydrofolate reductase OS=Haloarcula japonica GN=folA2 PE=3 SV=1
----LVIIAAVADNGVIGHNGELPW-H-PQDLKHFRAETI-----G--SPVIMGRKTFESIEKLGQPLPERKNIVLTRNGVSS-DRVI-EVGSIDEAL-E
A--K---ESKEQAYVIGGRSTYEEFLNRGIVDYLLITHIPRKY-GDTQWPGP---LDCIDCRN--I------S--EALVVSKYRIN-
>tr|A0A0J1BD26|A0A0J1BD26_9PLAN Dihydrofolate reductase OS=Rhodopirellula sp. K833 GN=RISK_003435 PE=3 SV=1
----ITAVVAATPDGVIGDEQDMPW-R-SSDLKRFKQTTM-----G--GALIMGRKTFESI---GRVLPGRQTIVLTRQDD-F-PGTQ-TASGKRDAI--
-------AAQRRIFVVGGGQIYQQWFPW--CTDLWWTRVWANI-GDTRIEL----EFEVVSQA--S----F-D--YPTDWLRMRRR-
>tr|A0A0E3U4G2|A0A0E3U4G2_9ENTR Dihydrofolate reductase OS=Blochmannia endosymbiont of Camponotus (Colobopsis) obliquus GN=folA PE=3 SV=1
----ISLIASLTINHVIGR-NCIPW-S-KLDMEWFKLHTL-----N--KPVIMGRKTFESI-G-GKGLVGRLNIVLSNCAR-VKNDVI-F---PQEAFKS
D-IV---VNSNEVMVIGGGKIYSIFMP-Y-ASRLYLTYLNIEVSGDVFFPFF---EWKLIFLK--F----Y-D--YILCFKIFERF-
>tr|E8Q5N5|E8Q5N5_BLOVB Dihydrofolate reductase OS=Blochmannia vafer (strain BVAF) GN=folA PE=3 SV=1
----ISLISILTINHVIGRKNIIPW-YFSIDMNWFKYHTT-----N--KPIIMGRKTFESIG--KKSLSNRINIVLSNRLS-NNENVI-FVDDPNKVLLV
-------NKSKEIMVIGGSALYKIFFP-K-CTRMYLTYINTVYNGDKWFPSYKK--WKVICDI--Y----K-M--YTLNFKIFDR--
>tr|R6CXE2|R6CXE2_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:594 GN=BN726_00671 PE=3 SV=1
----LILIAAVGKNGELGKNNDLIW-HIKEDMKFFKEKTI-----N--HHVLMGKNTFLSLPS---MLKDRTHIVLTTNKD---YNVI-VLHSLNETLSS
--------IDDDVYVIGGSKIYEEFID-Y-CDMMYLTEINDECLADCYFPSFRD--WQKKVLE--E----H-E--PPYKHIMYKKM-
>tr|A0A0R1IVR6|A0A0R1IVR6_9LACO Dihydrofolate reductase OS=Lactobacillus farciminis KCTC 3681 = DSM 20184 GN=FC68_GL000112 PE=4 SV=1
----ISFVWAEDKNHVIGVDGHLPWK-LPNDMKRFKDVTT-----N--HPIVMGRKTFESFP--NGPLPKRLNIVISRNPNYVPEGVV-LISNREQLK--
--------PDDEVMVIGGAGIFRMFED-I-VDRLYLTRINHEFVGDTKMVDL---QFKLIEKK--E----G-V--YPYTFETYQKI-
>tr|A0A0R2N410|A0A0R2N410_9LACO Dihydrofolate reductase OS=Lactobacillus crustorum GN=IV63_GL001428 PE=4 SV=1
----ISFVWAEDRNHIIGKNGHLPWK-LPNDMKHFKNVTM-----G--HPIVMGRRTYESFP--NGPLPNRLNIVISRNPNYVPDSVV-LITDKNELS--
--------SDEEVMVIGGEGIFKLFQN-D-VDRLYLTRIDYDFTGDTKMVNI---QFNLIEKK--E----G-V--YPHTFETYQKI-
>tr|A0A0R1QMB4|A0A0R1QMB4_9LACO Dihydrofolate reductase OS=Lactobacillus mindensis DSM 14500 GN=FD29_GL001902 PE=4 SV=1
----ISFVWAEAKNHVIGVDGHLPWT-LPNDMKRFKDVTM-----N--HPIVMGRKTFESFP--NGPLPKRLNIVISRNPDYVPESVV-LITDKSQLK--
--------PDDEVMVIGGAGIFDLFKD-D-VDRLYVTKIDHEFSGDVKMTKL---QFKLTEKK--E----G-I--YPYTFETYQRI-
>tr|A0A0R1I3J6|A0A0R1I3J6_9LACO Dihydrofolate reductase OS=Lactobacillus paralimentarius DSM 13961 = JCM 10707 GN=FC97_GL001023 PE=4 SV=1
----ISFVWAEDRNHIIGEKGHLPWS-LPNDLHHFKDVTI-----N--HPIVMGRKTFESFP--NGPLPKRLNIVISKNPDYVPDSVV-LINDKADLK--
--------SDDEVMVIGGSGIFKLFQD-D-VDRLYLTKIDYEFTGDTKMCSI---KFKLVEKK--E----G-I--YPYTFETWDKI-
>tr|A0A0R1WKV1|A0A0R1WKV1_9LACO Dihydrofolate reductase OS=Lactobacillus nantensis DSM 16982 GN=FD31_GL001046 PE=4 SV=1
----ISFVWAESKHHIIGVDGHLPWK-LPNDMKRFKDVTT-----G--HPIVMGRKTYESFP--NGPLPNRLNIVISRNPDYVPESVV-LLTDKNQLS--
--------PTEEAMVIGGEGIFKMFVD-D-VDRLYLTEIDHDFAGDTKMVEI---KFKLTEKK--E----G-I--YPYTFKTYDKI-
>tr|A0A0R1JCM8|A0A0R1JCM8_9LACO Dihydrofolate reductase OS=Lactobacillus tucceti DSM 20183 GN=FC72_GL000976 PE=4 SV=1
----ISFLWAEDKNHVIGYKGRLPWK-LPNDMKRFKDLTI-----G--KSIVMGRRTYESFP--NGPLPKRLNIVMSRNSKYVKEPAV-LINDISDLS--
--------MNSEIVVIGGSKIFEAFKD-I-VDRLYLTKIDYEFKGDVKMIDL---KFKLIEKE--G----G-I--YPYTFETYQRI-
>tr|A0A0R1K3D3|A0A0R1K3D3_9LACO Dihydrofolate reductase OS=Lactobacillus alimentarius DSM 20249 GN=FC67_GL001766 PE=4 SV=1
----ISFVWAEDENGVIGVNGHLPWK-LPNDMKRFKDVTT-----N--HPIVMGRKTFESFP--NGPLPKRLNIVISKNVDYVPESVV-LINDKVDLK--
--------SDEEIMVIGGRGIFQLFKD-D-VDRLYLTRIEHEFDGDTKMINL---KFKLIEKK--E----G-I--YPYTFETWQKI-
>tr|A0A0K2LC31|A0A0K2LC31_9LACO Dihydrofolate reductase OS=Lactobacillus heilongjiangensis GN=JP39_05505 PE=3 SV=1
----ISFVWAEDKNHIIGSNGHLPWK-LPNDMKRFKDVTT-----G--HPIVMGRKTFESFP--NGPLPNRLNIVISRNPDYVPDSVV-LLTDKNQLS--
--------AYEEVMVIGGEGIFKLFAD-D-VDRLYLTKIDYEFTGDTKMVEL---KFKLTEKK--E----G-I--YPYTFETYDRI-
>tr|A0A0R1LK05|A0A0R1LK05_9LACO Dihydrofolate reductase OS=Lactobacillus futsaii JCM 17355 GN=FC88_GL001029 PE=4 SV=1
----ISFVWAEDKNHVIGINGHLPWK-LPNDMRQFKDVTM-----N--HPIVMGRKTFESFP--NGPLPKRLNIVISRNPDYVPKGVV-LISDKEQLK--
--------ADDEVMVIGGAGIFKLFEK-D-VDRLYLTRIDHEFDGDTKMVDL---QFELVEKK--E----G-I--YPHTFETYQKV-
>tr|A0A0R2LNQ3|A0A0R2LNQ3_9ACTN Dihydrofolate reductase OS=Atopobium rimae GN=IV60_GL000471 PE=4 SV=1
----MNAIVSVARDWGIGCDGDLLIH-NKADMKYFVEHTL-----G--CTIIMGRRTFESFP-NG-PLKGRRNIVITRDSSWHE-GVE-VVSSPAAARAS
---E------EKVWLIGGASVYKEMLSD--CNCAYVTKHDIILPADSYFPNLDAPKWHVADVEKG------TPEGVAFEFVVYKQE-
>tr|R6N1V7|R6N1V7_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:302 GN=BN595_00857 PE=3 SV=1
----LALIAAVGYNNELGLDNRLLW-HIPEDLTFYKKMTM-----G--KNIIMGRNTFESMPV---ALKGRNPIVLSSKDI---YDVI-CYNNIENLLEN
--------SSDDFMVVGGAKVYKEFLP-Y-VDVMYLTELYKEF-ADAYFPYVDF--WDSIKIA--D----Y-N--IPYERNIYVRK-
>tr|R9LPL4|R9LPL4_9FIRM Uncharacterized protein OS=Firmicutes bacterium M10-2 GN=C815_01173 PE=4 SV=1
----LIEIAAIGKHNELGKNNEMIW-HLPKDLKFFRQTTQ-----G--KTIVMGRNTFLSLP---KMLPNRHHVVISKTME--RENIE-VFRDLQTFFSS
--------TEENVYVIGGGELYRSLLP-Y-SKELILTHIDAEDKAQVYFPAFD--NE-FNTEIIDE----D-T--NHVRY--IRK--
>tr|S2WWF0|S2WWF0_9ACTN Dihydrofolate reductase OS=Propionimicrobium lymphophilum ACS-093-V-SCH5 GN=HMPREF9306_01643 PE=3 SV=1
----LIAIAIVAANGVIGDGVDQPF-KFSEDFARFKRVTM-----G--HPLIMGRKTFDSM----GLLPGRFSIVIT-RTP-LDFRAI-AVSSLEEAI-A
---S---KRADVAYVLGGGQIYRAAMD-Y-LDEIDLTEVPKDA-GTVTFPELGV-QWQEVSRE--P----R------FDFVTYRRA-
>tr|R5YP41|R5YP41_9MOLU Dihydrofolate reductase OS=Mycoplasma sp. CAG:611 GN=BN735_00397 PE=4 SV=1
----LKMIAAVGKNNELGK-NDLIW-P-KEDLKFFKNVTT-----G--HTVIMGANTFFSL-PK--VLPNRTNIVLSQDDI-VPE--I-LYHDLNKFLKD
K--D---E---IVFVIGGGTIYRLFID-K-VNEIYLTEIDEVCNATVYFPTF---LYEKEILS--E----N-N--LNYKHVLYRRK-
>tr|A0A0J8DG59|A0A0J8DG59_CLOCY Dihydrofolate reductase OS=Clostridium cylindrosporum DSM 605 GN=dfrA PE=3 SV=1
----LSYVVAISENGVMGI-NTLPW-H-PNDLKFFKEVTLS---KS--KTMIMGRETFEAL-P--KILPERHHIVITRNRN-KINNVT-IIHNIDDLK--
-------ESPEEYFVIGGGQIFSLLMP-Y-AEKMYLTIIHEEFKGDTFFPKY---EWRILSKE--E----G-K--HNHTIYILERI-
>tr|U2D6L6|U2D6L6_9FIRM Dihydrofolate reductase OS=Clostridiales bacterium oral taxon 876 str. F0540 GN=HMPREF1982_02412 PE=3 SV=1
----LSFVVAIANNNVIGKDKSLAWGHLPSDMKKFKEITLS---GS--KTMIMGRKTFESLP---NILPERKHIILTKNEN-ADDDVE-VIHTMDEIM--
-------NSEEEYFVIGGGQIFNLLFP-Y-TEKMYITEIHEDFKGDTFFPTYD-SEWKVKAEK--E----G-K--YRHTFLILERI-
>tr|A0A075DX51|A0A075DX51_9CAUD Putative dihydrofolate reductase OS=Acinetobacter phage vB_AbaM_Acibel004 GN=vB_AbaM_Acibel004_30 PE=4 SV=1
----KVAIVAVGRNGEIGK-DKMLW-H-PEDFKYFKEMT-I----G--HAMIMGRKTWDGLPAP--LTRRCVHVVSKNC-N---T------NPLLSALKD
ACFH---LRTNIIWVAGGQRVYETTSD-I-VDEVFLTRVHADFEDTFYKVPEGF-FGGY-KSI-K-------G--WDVTFEKWVRK-
>tr|A0A059XEP9|A0A059XEP9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----ISIIAAIDEKRGLGK-NDLLF-K-PGDMQRLRTLTT-----G--HPLVMGRKTFASL---GRLLPNRTHIVITRDPE--LKPEV-VVSSLEEALKE
VSGT---EENEEVFIFGGGQIFTEAIEKGLVDRLYLTIVKGEYEADTFFPDY----FTKVVSK--E----D-G--YTYTFLDLEK--
>tr|A0A059X826|A0A059X826_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ISIIVAVDEKRGIGK-NDLLF-K-KEDMQRLRKLTD-----G--HPIVMGRKTFDSF---PGLLPNRTHIVITRDPE--YAPHF-VVSSLEEGIKT
---A---PGADEIFIFGGGQIFAEAVEKGLVDRIYLTIVKGDYKADTFFPDY----YTKVIEH--E----E-E--HQFTFLTLEK--
>tr|A0A059XF43|A0A059XF43_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----VSIIAAIDEKRGLGK-NDLLF-R-PEDGKRVRTLTS-----G--HPLIMGRKTFESL---GRLLPNRSHIVITRDPN--LKPDV-IVSSLEEGLKE
---Y---PGAEEIFIFGGGQIFTEAVKKDLVDRLYMTIVKGDFGADTFFPDY----FTKVIKK--E----D-G--YKYTFLDIEKQ-
>tr|A0A059X7D7|A0A059X7D7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----VSIIAAIDDKRGIGKNGSLLF-RIKEDMQRLRKITD-----G--HPLVMGRKTFD---SFPGLLPNRTHIVITRDPK---HPHV-VVSSLEDGIKN
---A---AGADEIFIFGGGQIFTEAIEKGLVDRLYLTIVKGDY-ADTFFPEYG------TKVI--E----K-G--YQYSFLTLEK--
>tr|A0A059XBJ2|A0A059XBJ2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----ISIIAAIDEKRGLGK-NDLLF-K-SGDMQRVRSLTT-----G--HPLVMGRKTFASL---GRLLPKRSHVVVTRDAS--LEPEA-VVGSLEEALKE
---F---EGAEEIFIFGGGQIFTEAVEKGLVDRLYLTIVKGEYDADTFFPDY----FTKILKK--E----E-G--YSYTFLDLEK--
>tr|A0A059X095|A0A059X095_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----VSIIAAIDEKNGLGK-NDLLF-K-PGDMQRVRSLTT-----G--HPLVMGRKTFASL---GRLLPQRSHVVITRDPS--LEPEA-VVSSLEEALQK
---Y---PGAEEIFIFGGGQIFTEAIEKDLVDRLYLTLVKGEYDADTFFPDY----FTKVITS--E----E-G--YSYMFLDLEK--
>tr|A0A059X915|A0A059X915_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----ISIIAAIDEKRGLGK-NDLLF-K-SGDMQRLRTLTT-----G--HPLVMGRKTFASL---GRLLPNRTHIVITRDPS--LEPEI-ITSSLEEALKN
VIAK---NKSGEIFIFGGGQIFTEAVEKGLVDRLYLTLVKGDYGADTFFPDY----FTKVLRQ--E----E-D--YSYTFLDLEK--
>tr|A0A0R1QRY1|A0A0R1QRY1_9LACO Dihydrofolate reductase OS=Lactobacillus manihotivorans DSM 13343 = JCM 12514 GN=FD01_GL001409 PE=4 SV=1
----IAFLWAEDAQGTIGKNGTLPW-HLPDDLKYFKQQTL-----G--TLTVMGRKTYWALP--KRPLPGRTNVVLSRDPEC-VAA-V-VVHSGAELRAQ
-------HPDMDLVITGGAGVFESLK-----DTLLVTRLAGKF-GDVTMVDL---DYQLVSTR--Q------A--LTHVFERWEKR-
>tr|A0A0R2B906|A0A0R2B906_9LACO Dihydrofolate reductase OS=Lactobacillus brantae DSM 23927 GN=FC34_GL000323 PE=4 SV=1
----IAFLWAEDADGIIGRNGRLPW-HLPDDLHYFRELTE-----G--QIVVMGRKTFEGL---KRPLPDRTNIVLTHQVDY-EADVI-VYHDAPAVIET
-------KPDQNLIIIGGANLFASFT-----DVLYRTKLAGHF-GDTHMLPI---QYALTKST--A------Q--LTHTFEVWTRK-
>tr|A0A0R2EZX7|A0A0R2EZX7_9LACO Dihydrofolate reductase OS=Lactobacillus camelliae DSM 22697 = JCM 13995 GN=FC75_GL000463 PE=4 SV=1
----IAFVWAQDQAGTIGKNGKLPW-HLPDDLHQFKQLTL-----G--QLTVMGRTTYEGLP--KRPLPGRTNIVLTHQEDY-QAA-V-VVHDRAELLST
-------HPQQRLMIVGGAQVFMAFA-----DRLYVTKLAGTF-GDVKMPPL---AFKQIASR--E------R--KTHVFETWARK-
>tr|A0A0E2LYT5|A0A0E2LYT5_LACCA Dihydrofolate reductase OS=Lactobacillus casei 5b GN=N422_04980 PE=3 SV=1
----VAFLWAQDRDGVIGKDGHLPW-HLPDDLHYFRTQTE-----G--KMMVVGRRTYESFP--KRPLPDRTNVVLTHQADY-QAA-I-VLHQVAEVLKE
-------HADQALVIAGGAQIFSAFK-----DTLLVTRLAGSF-GDTKMIPL---AFTKTSSR--T------A--LTHTYEVWQKQ-
>sp|P00381|DYR_LACCA Dihydrofolate reductase OS=Lactobacillus casei GN=folA PE=1 SV=3
----TAFLWAQDRDGLIGKDGHLPW-HLPDDLHYFRAQTV-----G--KIMVVGRRTYESFP--KRPLPERTNVVLTHQEDY-QAA-V-VVHDVAAVFKQ
-------HPDQELVIAGGAQIFTAFK-----DTLLVTRLAGSF-GDTKMIPL---DFTKVSSR--T------A--LTHTYEVWQKK-
>tr|A0A0F7HMK1|A0A0F7HMK1_9STAP Dihydrofolate reductase OS=Salinicoccus halodurans GN=AAT16_10940 PE=3 SV=1
----LAYVWAEDENKLIGKGSGLPWR-LPADVAFFKKITM-----R--GDMVTGRKTYETIP--NRPLPGRRNIILTAQRDYAPG-AI-VVHTKEEVL--
-------KNEEDLYIIGGAALFKIFAD-E-VDELYRTVIHDTFEGDTYFPDF---AFELVKTE--K----G-E--YEHTFELWRRK-
>tr|A0A078M6W3|A0A078M6W3_9STAP Dihydrofolate reductase OS=Jeotgalicoccus sp. 13MG44_air GN=dfrA PE=3 SV=1
----LAYVWAEDENRLIGKGDALPWR-LPADVAFFKKITM-----R--GDIVTGRKTYETIP--NRPLPGRKNIVLTTRQDYAPG-AI-VVHSKEEIL--
-------NGDEDLYIIGGAVLFKMFED-E-VDELYRTVIHKTFDGDTYFDEF---KFELVETE--K----G-I--YEHTFELWKRK-
>tr|A0A0C2HGR4|A0A0C2HGR4_9STAP Dihydrofolate reductase OS=Salinicoccus roseus GN=SN16_06575 PE=3 SV=1
----LAYVWAEDENKLIGRDKALPWR-LPADIKFFKDVTM-----Q--GDIVTGRKTYETIP--NRPLPGRRNIVLTLQADYAPG-AI-VVHSKEEIL--
-------ENGEDLYIIGGGTLFRLFED-E-VDVLYRTVIHDTFEGDTYFPEF---PFERVEAW--P----G-K--YPHTYEVWRRK-
>tr|A0A011SFE2|A0A011SFE2_9LACT Dihydrofolate reductase OS=Alkalibacterium sp. AK22 GN=ADIAL_2193 PE=3 SV=1
----ITFVWAEDQNRLIGREGDLPWN-LPADMAFFKKVTL-----T--GNVAMGRKTLDSIP--NPPLKNRVNYVMTRNQSFQPG-VV-ICHSKEELL--
-------KTDKPLHVIGGVSLFEAFID-E-VDMLYRTVIHDTFEGDTFMPEI---QFELVEKR--E----G-V--HAHTFEIYKRK-
>tr|S0NRG0|S0NRG0_9ENTE Dihydrofolate reductase OS=Enterococcus sulfureus ATCC 49903 GN=I573_01803 PE=4 SV=1
----LIALWAQDQNGVIGKDGKLPWS-LPNDMKFFKEQTT-----G--NAIIMGRKTFESMG--EKALPNRVNIVLTSDKDYAD-QVL-IFHTVEEIL--
-------QHEGKYYLIGGTGIFRSMLA-Y-CTDLYRTTIESEFEGDVYFPEEL--EWTLTKTI--P----G-H--YPHIFELFTKK-
>tr|K8ER46|K8ER46_CARML Dihydrofolate reductase OS=Carnobacterium maltaromaticum LMA28 GN=folA PE=3 SV=2
----IAYLWAQDEQGVIGNKGTLPW-SLPNDLKYFKEMTT-----G--NAIVMGRKTFEGMG--KRPLPNRINIVLTTDLGY-EAGVT-VMHTREEILKN
--------YEKDTFITGGTGVFNAFID-D-ADILYRTMIKGTFEGDTIFPEL---EWEIISAD--P----GER--YPHVFEAYKRK-
>tr|A0A0R1HT21|A0A0R1HT21_9LACO Dihydrofolate reductase OS=Lactobacillus algidus DSM 15638 GN=FC66_GL000233 PE=4 SV=1
----INFIWAEDDEQHIGYKGKLPWH-LPNDMKFFKKMTI-----N--KVVVMGRNTFESFP---GLLPNRVNVVVSSKSDL--ENLK-IVHSIPELN--
-------FSDD-IFVIGGATLFEEMYS-N-VDRLYQTKIHAIFDGDVTMVPI---DWQLVEKI--D----G-K--YQHEFRIYNRK-
>tr|A0A0M2CDP1|A0A0M2CDP1_ENTFL Dihydrofolate reductase OS=Enterococcus faecalis EnGen0411 GN=P011_00969 PE=3 SV=1
----LAAIWAQDEQGVIGKEGKLPW-HLPNDLKFFKEKTI-----H--NTLVLGRATFEGMG--CRPLPNRTTIVLTSNPDY-QAGVL-VMHSVEEILDK
--------YEGVTVIGGGSVVFKELIP-A-CDVLYRTMIHETFEGDTFFPEI---VWEKVATV--P----GEL--YAHDYETYHRN-
>tr|R2XZ96|R2XZ96_9ENTE Dihydrofolate reductase OS=Enterococcus gilvus ATCC BAA-350 GN=UKC_02575 PE=4 SV=1
----LIAIWAQDKNGLIGKDNHLPW-HLPNDLRFFKEMTL-----E--HTLVMGRKTFEGMG--GRPLPRRKTIVLTHDKDY-HANVL-IMHSLEEVLKK
--------NNGNIFIAGGSAIYTEFMP-H-CKKIYRTFIEASFEGDAYFPNT---EWQLTERR--Q----GDP--YRYYFETYERT-
>tr|A0A091C101|A0A091C101_9ENTE Dihydrofolate reductase OS=Tetragenococcus muriaticus 3MR10-3 GN=TMU3MR103_1405 PE=3 SV=1
----LAAIWAQDKNGVIGKDNKLPW-YLPEDLKFFKDSTV-----G--NTLVMGRKTFEGMG--SRPLPNRETIILTKAPSY-TANVK-ILHSTEEVVNQ
--------QSTPVFVGGGTEIFRELLP-H-FDYLYRTFIDESFAGDTYMPEV---HWKLIEKT--E----GER--YKHQFEIYGRK-
>tr|G4L8P5|G4L8P5_TETHN Dihydrofolate reductase OS=Tetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) GN=folA PE=3 SV=
----LIAIWAQDKNGLIGKDNKLPW-YLPNDLKFFKNNTI-----N--NTLVMGRKTFEGMG--GRPLPDRETIILTKDPNY-KANVK-ILHSIDEVINR
--------QSTPVFVGGGTEIFRELLP-H-FDYLYRTFIDEVFTGDTYMPEV---QWKLKEEK--E----GEH--YKHRFEIYERV-
>tr|S0NH60|S0NH60_9ENTE Dihydrofolate reductase OS=Enterococcus saccharolyticus ATCC 43076 GN=OMQ_00964 PE=4 SV=1
----LVALWAQDKNGLIGKDNQLPW-HLPADLKFFKETTI-----G--KTIVMGRKTFEGMG--KRVLPNRQTIVLTRDENY-QSGVL-VMHTVEEVLNK
--------VNHPVYIIGGALIFKDYLP-Y-CDELLCTLIDEEFDGDIYMPTI---QWQLVQTT--E----GER--YAHRYQTFARK-
>tr|R2RW80|R2RW80_9ENTE Dihydrofolate reductase OS=Enterococcus raffinosus ATCC 49464 GN=UAK_01334 PE=4 SV=1
----LIAIWAQDKNGLIGKENHLPW-HLPNDLRFFKETTI-----N--HTLVMGRKTFEGMG--GRPLPNRQTIVLTRDKEY-RANVI-VMHSLEEVIQN
--------HEGETFIAGGSAIYTEFLP-Y-CKKIYRTFIEASFEGDAYFPMM---KWQLTERK--Q----GEP--YLYYFETYERA-
>tr|B1ZSC9|B1ZSC9_OPITP Dihydrofolate reductase region OS=Opitutus terrae (strain DSM 11246 / PB90-1) GN=Oter_2446 PE=3 SV=1
----FNVIVACSENRVIGRAGRLPW-RIPEDWSFFRQRTA-----R--STVVLGRISFQSWRSVLE--DERRAVVLTRNTS-AGDRVE-VAHSLTAGLAA
---G---AHGREIYVCGGQRVFAEALP-S-ATRLYLTLIHAHV-GDRTFPEWR--EFPRVLEQ---------N--YRYTFFTLARA-
>tr|A8UAT9|A8UAT9_9LACT Dihydrofolate reductase OS=Carnobacterium sp. AT7 GN=CAT7_11750 PE=3 SV=1
----IAFLWAQDQNGAIGYQGTLPW-YLPNDLKFFKQMTI-----N--NAVVMGRKTFEGMN--KRPLPNRINIILTTDPNY-QAGIK-VMHSREEVLKE
--------YSGDTLITGGANVFSFFMD-D-VDVLHRTMIEGEFKGDTFMPEI---QWKLDKIE--A----GDK--YPHVFETYVRN-
>tr|A0A0R2HP90|A0A0R2HP90_CARDV Dihydrofolate reductase OS=Carnobacterium divergens DSM 20623 GN=IV74_GL001928 PE=4 SV=1
----IAYLWAQDENGTIGYQGTLPW-RLPNDLKFFKEKTI-----H--NAVVMGRKTFEGMG--KRPLPNRINIILTTDPTY-EAGVT-VMHSRQEVLKT
--------YEKDTFITGGTGVFKDFLE-D-ADVLYRTIIKGEFKGDTQFPPL---EWKIIEAT--P----GER--YPHVFETYVRK-
>tr|F4BQE4|F4BQE4_CARS1 Dihydrofolate reductase OS=Carnobacterium sp. (strain 17-4) GN=dfrA PE=3 SV=1
----IAFLWAQDKNGAIGYKGTLPW-YLPNDLKFFKQMTI-----N--NAVVMGRKTFEGMN--KRPLPDRINIILTTDLNY-QAGVK-IMHSREEVLKD
--------YSGDTFITGGAKVFSFFMD-D-VDVLHRTMIEGEFEGDTFIPEI---KWKLEKIE--E----GEK--YPHVFETYARK-
>tr|A0A069CSN8|A0A069CSN8_9LACT Dihydrofolate reductase OS=Weissella oryzae SG25 GN=WOSG25_030080 PE=3 SV=1
----VIMIWAQSRNGTIGKNGQIPW-H-QADMRFFKATTL-----H--KVVLMGRKTMTSFG--GHPLSNRTNLVLTRQPA-LPAKV----TDFAAAL-A
-------AAKQDLVVIGGKAVYELAFK-Y-ADELLVTYLETEIAGDVSMAAL---NWQSELIF--A----G-D--YAYRVMRYRRK-
>tr|E6LFI6|E6LFI6_9ENTE Dihydrofolate reductase OS=Enterococcus italicus DSM 15952 GN=folA PE=3 SV=1
----LVALWAQDADGLIGNQGTLPW-HLPNDLKFFKEQTM-----N--HTIVMGRKTFEGMD--GKVLPKRTSIVLTSDKAYA-PGVI-VMHTRQEVLVA
-------KTNEPVFLIGGSGVFESLLS-E-CTDLYRTWIDHRFSGDVYFPEH---DWTRTKVI--E----G-P--YPHRFEFYQRT-
>tr|R2RET8|R2RET8_ENTCA Dihydrofolate reductase OS=Enterococcus flavescens ATCC 49996 GN=UAM_02645 PE=4 SV=1
----LIALWAQDQKGLIGADGTLPW-HLPNDLKFFKEQTI-----N--NTIIMGRKTFEGMG--KRLLPQRTTIVLTSDRDY-QAGAL-VMHDREEILKQ
--------QEHPVFLTGGAGVFEAMID-D-CDQLYRTVIAAEFNGDVYFPEI---QWKLDHVI--D----GEH--YPHQFEFYRRK-
>tr|A0A0N1CRG6|A0A0N1CRG6_9ENTE Dihydrofolate reductase OS=Enterococcus sp. RIT-PI-f GN=AEQ18_11955 PE=3 SV=1
----LIALWAQDNQGLIGENGTLPW-HLPNDLKFFKEQTI-----H--NTIIMGRKTFEGMD--RRPLPQRTTIVLTKDPSY-QAGVL-VMHDREEVLNA
--------QDHPVFLTGGAGVFKTMID-D-CDQLYRTVIDERFTGDVFFPAI---KWQLTKTI--P----GDK--YRHRFEFYQKK-
>tr|C8ZZ85|C8ZZ85_ENTGA Dihydrofolate reductase OS=Enterococcus gallinarum EG2 GN=EGBG_01254 PE=3 SV=1
----LIALWAQDKNGLIGENGTLPW-HLPNDLKFFKEQTT-----G--NSLIMGRKTFEGMK--KKALPNRTTIVLTSDTAY-EAGVL-VMHDRQEVLAQ
--------QDHPVFLTGGSGVFESMIE-D-CDQLYRTVIDETFTGDVYFPEI---NWHLDKVI--E----GEI--YPHRFEFYSKQ-
>tr|S0KDS3|S0KDS3_9ENTE Dihydrofolate reductase OS=Enterococcus dispar ATCC 51266 GN=OMK_01183 PE=4 SV=1
----LAAIWAQDQNGLIGKNEVLPW-YLPDDLKFFKEMTI-----G--KTLVMGRRTFEGMG--GRPLPGRTTIILTRNENY-QAGVY-VMHDVNEIIKN
--------EDQTVFIAGGAAIYTALLP-Q-CDYIFRTVIEDSFEGDTYFPAI---NWRLIKKA--A----GEK--FPHTFEEYERI-
>tr|D4YDX3|D4YDX3_9LACT Dihydrofolate reductase OS=Aerococcus viridans ATCC 11563 GN=folA PE=3 SV=1
----LIAIWAQDINHLIGKGGKLPW-HLPNDLKFFKDQTV-----G--KTVVMGRKTYAGLD--YKPLPNRHNIIITRQKSPESDDVE-LTDSIDNILA-
--------EKEDVIIMGGHSIYRLFWP-Y-ISELRVTTIHHEFDGDVHFDP----DFEAYEVI--E----G-A--YPHKFVFYRKV-
>tr|S4E3F3|S4E3F3_ENTFL Dihydrofolate reductase OS=Enterococcus faecalis 13-SD-W-01 GN=D920_02684 PE=3 SV=1
----FISMWAQDKNGLIGKDGLLPW-RLPDDMRFFREHTM-----N--RILVMGRKTYEGMG--ELSKPYRKIIVLTTRKDLV-KNAQ-VMHSIDELLSK
-------TVDEDIYISGGGDIFRALLP-Q-TGIIWRTLIDEEFTGDTYIGE----GFELVEER--E----G-L--YPHRFQKWVRT-
>tr|A0A0I9WQJ4|A0A0I9WQJ4_9ENTE Dihydrofolate reductase OS=Enterococcus cecorum GN=AA988_00755 PE=3 SV=1
----ITAIWAQDKNGLIGKDGLLPW-KLPNDLNFFKSKTM-----K--GTLVMGRKTYEGLG--KRSKAYKKIYVCTRQNELL-YNAE-IIHSPEEVL--
----------EDLHVGGGGDIFRLFLP-Y-TDVIYRTLIDVEFTGDAYIGE----DFELVEEI--P----G-I--YPHVFQKWVRK-
>tr|A0A0H1S7K9|A0A0H1S7K9_9MOLU Dihydrofolate reductase OS=Mycoplasmataceae bacterium CE_OT135 GN=MRECE_15c018 PE=4 SV=1
----INLIWAMDQDYIIGKDNSLPW-KIKEEMQYFTQTTQ-----G--HTILMGRKTFESIG---KPLGKRRNIVLTKNQK-KKTQLV-IENNLASIITN
-------QP-EQLFIIGGREIFHQTYP-F-ADQLYISVIKERY-GNIKLDFFP--DFQLREQK--E----F-----QFIIKIYHRK-
>tr|A0A0H3UGI6|A0A0H3UGI6_9ENTE Dihydrofolate reductase OS=Melissococcus plutonius S1 GN=folA PE=3 SV=1
----LSAIWAQDEQGTIGLNDKLPW-HLPNDLKFFKQTTE-----N--NTLIMGRKTFEGMG--KRSLPNRITIVLTHDQHY-QVGVL-VMHTINEVLKN
--------FSGITFITGGATVYKAFLP-Y-CEVLYRTVIHHTFKGDTQFPKV---EWTKINTS--K----GEN--YSYEFETYQRK-
>tr|A0A0R1X2K3|A0A0R1X2K3_9LACO Dihydrofolate reductase OS=Lactobacillus graminis DSM 20719 GN=FC90_GL001132 PE=4 SV=1
----LAFLWAEDQNGLIGQNGHLPWS-LPNDLANFKHETI-----H--EVVVMGRKTYDSLP--ARPLPSRQNVVITRQSELVADGVL-VMHNKAELL--
-------NPMKKIFIIGGADIFAMFAD-D-VDYLYVTKIAASFEGDIYMPKL---QFELISQT--P----G-R--YTHTFEIYQRI-
>tr|A0A0R1LAL6|A0A0R1LAL6_LACCU Dihydrofolate reductase OS=Lactobacillus curvatus JCM 1096 = DSM 20019 GN=FC08_GL000603 PE=4 SV=1
----LAFLWAEDQNGLIGQNGHLPWS-LPNDLANFKHETV-----H--EVVVMGRKTYDSLP--VQPLPGRQNIVITRQPDLVADGVF-VMHTKAELL--
-------NPMKKIFIIGGADIFAMYAD-D-VDYLYVTKIAESFEGNVYMPKL---QFELISQT--P----G-R--YAHTFEIYQRR-
>tr|A0A0R1RNE5|A0A0R1RNE5_9LACO DfrA protein OS=Lactobacillus fuchuensis DSM 14340 = JCM 11249 GN=FC69_GL000265 PE=4 SV=1
----IAFLWAEDQNGLIGQDGHLPWR-LPNDLANFKRETI-----N--EVVVMGRKTYDSLP--KRPLPGRQNIIITRQVGLAEPGVL-VMTQSAELL--
-------NPTKKLFIIGGAEIFNLFKA-H-VDYLYVTKIAAAFKGDVYMPEL---QFKRIDVK--A----G-R--YPHTFEIYQRL-
>tr|Q38WX9|Q38WX9_LACSS Dihydrofolate reductase OS=Lactobacillus sakei subsp. sakei (strain 23K) GN=dfrA PE=3 SV=1
----IAFLWAEDQNGLIGQDGHLPWR-LPNDLANFKRETI-----N--EAVIMGRKTYDSLP--KKPLPGRQNIVITRQSGLVAKDVL-VFNERTQLL--
-------HPMQKLFIIGGADIFKLFAA-D-VDYLYVTKIAEKFKGDVYMPTI---QFKLISQK--A----G-Q--YPHTFEIYQRI-
>tr|A0A098S2U1|A0A098S2U1_9SPHI Dihydrofolate reductase OS=Phaeodactylibacter xiamenensis GN=IX84_21325 PE=3 SV=1
----IVMIAARSDNGVIGKDGGLPW-SMPADEAFFLNEIE-----G--CFLLSGRKSYESNQ---GNTIDKQFVIITRRKN-V-GGGE-IAHSVEEGIAR
---H---KQVPRRCVLGGGEIYRQALP-Y-ADELILTDIHTQVEGDAFFPAFSA-DWKLTQQE--P----H-P--FPYTFK-WFRR-
>tr|A0A0R1GPB0|A0A0R1GPB0_9LACO Dihydrofolate reductase OS=Lactobacillus bifermentans DSM 20003 GN=FC07_GL000825 PE=4 SV=1
----LAYIWAEDQAHTIGLNGQLPWH-LPADMHYFKTTTQ-----D--NLVIMGRRTFASFG--GRPLPQRVNIVLTHQMDFAPENVI-VCHTKADVL--
-------YPDQIPFIIGGATLYELFKQ-D-VQLLYVTRIQTRVTGDTKMPAL---AFQLQQQQ--T----Y-R--YAYTFECYQRK-
>tr|X0PQ27|X0PQ27_9LACO Dihydrofolate reductase OS=Lactobacillus composti DSM 18527 = JCM 14202 GN=FC83_GL002417 PE=3 SV=1
----LAFIWAESKNHVIGANGKMPWH-ISDDLKYFKKTTL-----N--HCIVMGRKTFASFG--GRPLPQRQNIVLSRQNELLPAGVM-QCHDQAAVL--
-------HPQTQVFIIGGAQVFTLFMD-V-VQRLYVTRIQKEITGDTYMPPI---AFKRVSQV--P----G-E--FPHQFEIYDRI-
>tr|W1Q566|W1Q566_ABIDE Dihydrofolate reductase OS=Abiotrophia defectiva ATCC 49176 GN=GCWU000182_000017 PE=3 SV=1
----LTLVYAQDQAGGIGYQNQLPWH-LPNDLKFFKQVTL-----G--HAILMGRKTFESMG--CRLLPGRTSYVLTRQEDYSEIGLH-RVHNLEAIK--
---------DQEVMVIGGAEIFAALLP-L-ADRVIRTQIKATFPADTFVADL---QWQCVEIQ--E----G-Q--YAHQFEWWVRR-
>tr|H3NKK2|H3NKK2_9LACT Dihydrofolate reductase OS=Facklamia languida CCUG 37842 GN=HMPREF9708_01391 PE=3 SV=1
----ITFVYAQDRKGAIGYRNQLPWH-LPNDLKFFKEVTM-----G--HTMLMGRHTFEGME--KRLLPGRKTVVMTSNPDYQEIELE-VVTSVEE----
-------AQDQELMVIGGAGVFKSLWD-H-VDLIVRTVIDGEFPADVYMPPI---EFECIKSK--P----G-P--YPHTFEWWQRK-
>tr|K1LI60|K1LI60_9LACT Dihydrofolate reductase OS=Facklamia hominis CCUG 36813 GN=HMPREF9706_00348 PE=3 SV=1
----ITFVYAQDLKGAIGYRNDLPWH-LPNDLKFFKKVTM-----G--HTTLMGRNTFESMN--RRLLPGRQSVVLTSDLNYQEIGLT-CVHSIDQVL--
---------DQELMVIGGAGVFKQLFD-H-ADKIIRTVIEAEFEADTYMPKI---LFERVNVE--E----G-P--YAHRYESWLRK-
>tr|R3U2L3|R3U2L3_9ENTE Dihydrofolate reductase OS=Enterococcus phoeniculicola ATCC BAA-412 GN=UC3_00616 PE=4 SV=1
----FLSMWAQDRKGLIGKDGLLPW-RLPNDMQFFQEHTM-----N--SLLAMGRKTYEGMD--YRSEKYRHIFVLTQQETFV-RNAE-VVSSIDKLVSK
-------QTDEDIYVSGGSRIFKEMLP-Y-TSVIWRTLIDAEFDGDTYIEE----EFELEEEI--Q----G-H--YPHVFQKWVRK-
>tr|C8NE93|C8NE93_9LACT Dihydrofolate reductase OS=Granulicatella adiacens ATCC 49175 GN=folA PE=3 SV=1
----LIYIWAQDERGLVGKDGTLPWR-LPNDLKFFKEVTM-----G--QTILMGRKTFEGMG--SRLLPGRQTIILTTSSDYVPG-AE-VVTNIEEIV--
-------SRHEDIYVCGGAQVYNLLKN-H-VELLYCTRIHASFEGDSYFPTF---DFIKVKSL--E----G-L--YPHTFEIYERK-
>tr|A0A0J7HBG5|A0A0J7HBG5_OENOE Dihydrofolate reductase OS=Oenococcus oeni GN=AAX20_07295 PE=3 SV=1
----ITSIWAQSKNNVIGRNNHLPWS-LPDDLKFFRQETK-----N--KAVVMGRKTYESFG--SKALPKRLNIILTSNMDFSNDEVK-IVHSPIEAV--
-------EQHLPLYVIGGASVYESFMN-M-ADRLLITLVDANIKGDTFAPNF---SFSLVSQC--H----H-A--YSFDFLTYERK-
>tr|G9WH27|G9WH27_9LACT Dihydrofolate reductase OS=Oenococcus kitaharae DSM 17330 GN=OKIT_1433 PE=3 SV=1
----ITAIWAQSKNNVIGNQGKLPWS-LPDDLKFFKQQTT-----G--KAIVMGRKTFESFG--SRALPKRLNIILTHNQHFVPDKIK-IVHSPQEAI--
-------EAALPLYIIGGAAVYQTFMT-Q-TDCLLVTLVNTEITGDTFAPQI---IFRLASKK--H----H-A--YSFDFLTYLRK-
>tr|A0A0R2IFA9|A0A0R2IFA9_9LACO Dihydrofolate reductase region OS=Pediococcus inopinatus GN=IV83_GL000737 PE=4 SV=1
----LAFIWAESKNGIIGSQNKLPWR-IPDDTRYFKQLTT-----N--HPVVMGRKTFESFG--AKALPNRLNIVLTRQTDLETNNLK-VYHSVSEFL--
-------SDQRLIFIIGGKEIYRQLYP-Y-AEMLYRTRIDKEYTGDTKMINI---EWTLEESL--T----G-P--IPHFFEVYTRN-
>tr|A0A059WYG5|A0A059WYG5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRAIAAIDDKRGIAAGGKIPW-RIPEDTRYYKEKTE-----H--STVVMGWATYEEFA---EPLPNRRNLVVSRTDQ-IRPGFE-LVTDVDSY-LQ
-------HATEDIWIIGGAGLFSTTLQ-Y-CEELYLTHVAGDF-CDRIFPVYE--AFTLAESS---------P--YHFRYNVYRRT-
>tr|A0A0R2IVQ1|A0A0R2IVQ1_9LACO Dihydrofolate reductase OS=Pediococcus cellicola GN=IV80_GL000149 PE=4 SV=1
----LAFVWAETKNGIIGSDGKLPWH-IPDDMHYFKELTT-----G--HPVIMGRKTFESFG--GKPLPNRLNIVLTRKDTLETQNLK-VSHSVKELI--
-------SSQKLIFVIGGREIYQQFYP-Y-VTRLYRTYIDMTISGDTKMIPI---QWCLVASH--H----G-P--IPHTFEIYERK-
>tr|A0A0R2K8F6|A0A0R2K8F6_9LACO Uncharacterized protein OS=Pediococcus ethanolidurans GN=IV87_GL002100 PE=4 SV=1
----LAFIWAESKNGIIGNQNTIPWR-IPDDTSYFKKITT-----G--HTVIMGRKTFESFG--AKPLPNRLNVILTRQKTLETKNLK-VSHSVSDLL--
-------STTELVFVIGGKQIYQQFYP-Y-VKRLYRTYIDQNFSGDTHMIPI---EWQLIKTV--L----G-P--IAHTFEVYERI-
>tr|A0A0R2IV28|A0A0R2IV28_9LACO Dihydrofolate reductase region OS=Pediococcus parvulus GN=IV85_GL003475 PE=4 SV=1
----LAFIWAESQNGVIGKQNKLPWR-IPDDTQYFKKITT-----G--HTVIMGRKTFESFG--AKPLPHRLNVVLTRKTTLETEELK-VSHSITDLL--
-------SNDELVFVIGGKEIYQQLYP-Y-VQMLYRTRIEQDFEGDTQMIPI---QWQLMQSI--P----G-P--IPHVFEIYKRI-
>tr|A0A0R2HU47|A0A0R2HU47_9LACO Dihydrofolate reductase region OS=Pediococcus damnosus GN=IV84_GL001406 PE=4 SV=1
----LAFIWAESKNGVIGSHNQLPWH-IPDDTSYFKQLTT-----N--HPVVMGRKTFESFG--AKPLPNRLNIVLTRQTSLETDNLK-VYHSVEKFL--
-------SDSRLIFIIGGKEIYRQLYP-Y-AEKLYRTRIDDCFAGDTKMIAI---KWRLVETL--T----G-P--IPHRFEVYERK-
>tr|A0A0R1JPK5|A0A0R1JPK5_9LACO Dihydrofolate reductase OS=Lactobacillus nasuensis JCM 17158 GN=FD02_GL001234 PE=4 SV=1
----VTFLWAQDQAGTIGQAGHLPW-HLPDDLKFFKATTL-----G--QLMLVGRTTYEGLP--QRPLPGRTNLVLTRRHDY-AAA-V-MVHSVADALTM
-------HPGSELIVTGGAQVFTAFM-----QTLLVTRIAGQF-GDVTMPPV---EFKRVSAK--A------E--LAHVFEKWERQ-
>tr|R2PQM8|R2PQM8_9ENTE Dihydrofolate reductase OS=Enterococcus asini ATCC 700915 GN=UAS_01299 PE=4 SV=1
----LIAIWAQAEDGLIGQAGHLPWH-LPADLQYFKEQTL-----G--KTIVMGRKSFEGMG--SRALPKRKTLLLTSDHSYVTDNVQ-VMHQISEVL--
-------AAETPVYIAGGAQVYKAFEP-Y-YDVLLRTVIEGEFQGDTYFPDF---GYRLVETR--P----G-H--YPHHFEMWQKR-
>tr|V6Q4B8|V6Q4B8_9ENTE Dihydrofolate reductase OS=Vagococcus lutrae LBD1 GN=T233_00881 PE=3 SV=1
----LAAIWAQDEEGLIGKDDALPW-RLPNDLSFFRNTTE-----N--NTIVMGRKTFEGMN--KRPLPNRHTIVLTSDTSY-QAGIQ-VMHTVEEVLES
--------YDGIVFITGGANVYRQFFP-Y-ADILYRTVIHETFEGDTYIPEP---DWSMIDIS--E----GAR--YAHTFETYKRK-
>tr|S4CWI8|S4CWI8_ENTFL Dihydrofolate reductase OS=Enterococcus faecalis 13-SD-W-01 GN=D920_02835 PE=3 SV=1
----LAAIWAQDEKGLIGKDDQLPW-YLPNDLKFFKQMTE-----L--NTLVMGRKTFEGMG--GRPLPNRQTIVLTRDLTY-QAGVI-VMHAMEEVLKE
--------HDGIVFIAGGAAVYQEFLP-Y-CAILYRTVIHHGFEGDTYFPPV---EWSLINLS--T----GER--YPYQFETYQRK-
>tr|R2TEM7|R2TEM7_9ENTE Dihydrofolate reductase OS=Enterococcus haemoperoxidus ATCC BAA-382 GN=UAW_01180 PE=3 SV=1
----LAAIWAQDEQGTIGKENRLPW-HLPNDLKFFKQMTE-----N--NTIVMGRKTFEGMG--SRPLPNRQTIVLTTDKEY-HAGVL-VYHTVSDVLKT
--------FSGITFIAGGSAVYENFLP-H-CDVLYRTVIHHSFEGDTKFPPV---DWTLINLS--E----GES--YAHQFETYQRK-
>tr|R3WR89|R3WR89_9ENTE Dihydrofolate reductase OS=Enterococcus caccae ATCC BAA-1240 GN=UC7_02389 PE=3 SV=1
----LAAIWAQDEKGTIGKDDRLPW-HLPNDLKFFKQMTE-----D--NTIVMGRKTFEGMG--SRPLPNRQTIVLTRDRTY-HAGVL-VFHTVEEVLKT
--------FAGITFIAGGSAVYEDFLP-H-CDVLYRTVIHHSFDGDTKFPPV---EWTLINLS--E----GEN--YDYQFETYQHK-
>tr|R2SZ63|R2SZ63_9ENTE Dihydrofolate reductase OS=Enterococcus moraviensis ATCC BAA-383 GN=UAY_01571 PE=3 SV=1
----LAAIWAQDEEGTIGKENRLPW-HLPNDLKFFKQMTE-----D--NTIVMGRKTFEGMG--SRPLPNRQTIVLTRDREY-QAGVI-VLHTIEEVLKS
--------FSGITFISGGSAVYEDFLP-Y-CDVLYRTVIHHSFEGDTKFPFV---DWALINLS--M----GEH--YAYQFETYQRK-
>tr|R3TPQ8|R3TPQ8_9ENTE Dihydrofolate reductase OS=Enterococcus phoeniculicola ATCC BAA-412 GN=UC3_02035 PE=4 SV=1
----LAAIWAQDEAGLIGKQEHLPW-HLPSDLKFFKQMTE-----S--NTLIMGRRTFEGMG--GRPLPNRKTIVLTRDLTY-QAGVD-VMHTLDDVLKE
--------FEGITFVAGGSMIYEEFLP-Y-CTVLYRTLIHHTFEGDTYFPTV---QWSLINLS--E----GEL--YPFQFETYHRR-
>tr|R2SN20|R2SN20_9ENTE Dihydrofolate reductase OS=Enterococcus villorum ATCC 700913 GN=UAO_01315 PE=4 SV=1
----LAAIWAQDENGLIGKEERLPW-RLPNDLKFFKQMTE-----A--NTLVMGRKTFEGMG--SRPLPNRQTIVMTRDRNY-QAHVL-VMHDVQEVLKE
--------NDGILFVAGGSVIYKEFLP-F-CTILYRTVIHHSFEGDTYFPEI---QWSLINIS--Q----GEP--YAYQFETYQRK-
>tr|R2MNI1|R2MNI1_ENTMU Dihydrofolate reductase OS=Enterococcus mundtii ATCC 882 GN=UAC_01937 PE=4 SV=1
----FAAIWAQDENGLIGKEDRLPW-HLPNDLKFFKQMTE-----A--NVLIMGRKTFMGMG--GKPLPNRKTIVLTRDREF-TAGVL-VMHDVNEVLKE
--------ADEILFVAGGSAIYEEFLP-Y-CTILYRTVIHHSFEGDTYFPAV---AWSLINIS--P----GES--YAHQFETYKRK-
>tr|W1K8I3|W1K8I3_9ENTE Dihydrofolate reductase OS=Enterococcus durans IPLA 655 GN=H318_08244 PE=3 SV=1
----LAAIWAQDENGLIGKENKLPW-RLPNDLKFFKQMTE-----S--NTLVMGRKTFEGMG--SRPLPNRHTIVLTHNRDY-TAGVM-VMHSIDEVLKE
--------TDGIIFIAGGSTIYKEFLP-F-CTVLYRTVIHHTFEGDSYFPTL---DWSMINVS--Q----GER--YNHQFETYQRK-
>tr|V5XQD3|V5XQD3_ENTMU Dihydrofolate reductase OS=Enterococcus mundtii QU 25 GN=folA PE=3 SV=1
----FISMWAQDKNGLIGKDGLLPW-RLPNDMRFFREHTV-----D--RLLVMGRKTYEGMG--DLSLPYRHIIVLTTQEDFV-KNAE-VMHSIDELLAE
-------TVSEDIYVSGGSRIFQELLP-Q-TGIIWRTLIDGEFEGDTYIGE----DFELAEEH--I----G-H--YAHRFQKWVRK-
>tr|R2S3V7|R2S3V7_9ENTE Dihydrofolate reductase OS=Enterococcus villorum ATCC 700913 GN=UAO_02297 PE=4 SV=1
----FISMWAQDRNGLIGKDGLLPW-RLPNDMRFFREHTM-----N--KILVMGRKTYEGMG--ELSLPYRHIIVLTTQKDFV-ENAE-VFHSIEELLAK
-------DVSEDIYVSGGSQIFQDLLP-E-TGIIWRTLIDGEFEGDTYIGE----DFELVEEH--E----G-R--YAHRFQKWQKK-
>tr|I6SE23|I6SE23_ENTHA Dihydrofolate reductase OS=Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NC
----FISMWAQDKNGLIGKDGLLPW-RLPNDMRFFREHTM-----D--KILVMGRKTYEGMG--KLSLPYRHIIVLTTQKDFV-ENAE-VLHSIDELLAK
-------DIPEDIYVSGGSRIFQALLP-E-TKIIWRTLIDAEFEGDTFIGE----SFELVEEH--E----G-Q--YPHRFQKWQKM-
>tr|S0S1Y1|S0S1Y1_9ENTE Dihydrofolate reductase OS=Enterococcus durans ATCC 6056 GN=I571_01857 PE=4 SV=1
----FISMWAQDRNGLIGKDGLLPW-KLPNDMRFFREHTM-----N--RILVMGRKTYEGMG--KLSLPYRKIIVLTSQTDFV-ENAE-VMHSIEELLAK
-------NCSEDIYVSGGSRIFQELLP-E-TGIIWRTLIDATFEGDTFIGE----DFDLVEEH--V----G-Q--YPHRFQKWQRR-
>tr|R2MBM2|R2MBM2_ENTFC Dihydrofolate reductase OS=Enterococcus faecium EnGen0263 GN=UA3_01147 PE=3 SV=1
----FISMWAQDRNGLIGKNGLLPW-RLPNDMRFFREHTM-----D--RILVMGRKTYEGMG--DLSLPYRHIIVLTTQPNFT-KNAE-VMHSIDELLSQ
-------TISEDIYVSGGSRIFQELLP-Y-TGRIWRTLIDSTFEGDTYIGD----DFALIEEH--E----G-L--YAHRFQKWERV-
>tr|U4TT27|U4TT27_9LACO Dihydrofolate reductase OS=Lactobacillus shenzhenensis LY-73 GN=folA PE=3 SV=1
----LAFIWAEDRNHLIGTHGRLPW-HLPDDLRYFKATTL-----H--HTILMGRRTWDSLP--TKPLPERTNIVLTHRPLT--TGVQ-TLGSVMAVQTE
-------HPDETVFIIGGRSLFEAFM-----DRLYVTRIDHAFPGDAYMVPW---AFTVIQDT--P-----EP--WPHRFMIYARR-
>tr|A0A0R1XFK1|A0A0R1XFK1_9LACO Uncharacterized protein OS=Lactobacillus harbinensis DSM 16991 GN=FC91_GL001853 PE=4 SV=1
----LAFIWAEDRNHLIGTDDHLPWH-LPDDLHYFKKITE-----G--HTILMGRRTWDSLP--TKPLPNRTSIVLTHRPIT--PGVT-TLGDVAAVQ--
-------HAAETIFIIGGRSLFAAFMN-Q-VDRLYVTRIDHEFPGDTYMVPW---DFQEIKRT--P----G-P--WPHAFVVYARH-
>tr|A0A0R1N1J7|A0A0R1N1J7_9LACO Uncharacterized protein OS=Lactobacillus perolens DSM 12744 GN=FD09_GL001286 PE=4 SV=1
----LAFIWAEDKNHLIGVKDRLPWH-LPDDLHYFKVTTE-----G--HPIIMGRRTWDSLP--TKPLPKRENIVLTHRPID--AGVT-SLPDVAAVQ--
-------HSQDTVFIIGGRSLFEAFMP-Q-VDQLFVTQIDHEFPGDTYMVNW---QFQLLRAT--P----G-P--WPHTFAVYERK-
>tr|R2SKA4|R2SKA4_9ENTE Dihydrofolate reductase OS=Enterococcus pallens ATCC BAA-351 GN=UAU_04449 PE=4 SV=1
----LIAIWAQDKNGLIGKNDRLPW-HLPNDLRFFKEKTV-----N--NTIVMGRKTFEGMG--GRPLPNRQTIVLTRNTDY-QNQVL-VMHSLEEVLQQ
--------TEMITYIAGGSSVYQEFLP-Y-CDCLYRTKIDHVFEGDAYFPSI---DWQLIDQA--Q----GEL--YPHVFETYKNN-
>tr|C9B6C7|C9B6C7_ENTFC Dihydrofolate reductase OS=Enterococcus faecium 1,231,501 GN=EFRG_01172 PE=3 SV=1
----LAAIWAQDENGLIGKEDRLPW-RLPNDLKFFKQMTE-----A--NTLVMGRKTFEGMG--SRPLPNRQTIVLTRDSSF-KAGVH-VMHSVEDVLKE
--------TDGIFFIAGGSAVYQEFLP-F-CTILYRTVIHHVFDGDAYFPPV---DWSLINTS--Q----GER--YPHQFETYQRN-
>tr|A0A0R2CHA6|A0A0R2CHA6_9LACO Dihydrofolate reductase OS=Lactobacillus thailandensis DSM 22698 = JCM 13996 GN=FD19_GL000883 PE=4 SV=1
----TAFIWAQDRNRVIGRDGKLPW-RLADDLKFFKATTL-----N--QAVIMGRRTFAGMG--SRALPQRQNIVLTHQADF-QAGVV-VVHSMEAALNT
-------GDHDVAFVIGGAGVFTSFLT----DKLYVTRIHGAF-GDTKMVLL---QYRRDSAR--T------K--LTHTFEQWVYA-
>tr|H9NC35|H9NC35_9CAUD Gp158 OS=Sphingomonas phage PAU GN=158 PE=4 SV=1
----LNIIVAQTKNNVIGIGNNLPWA-MGIDMKNFKLRTT-----G--NIVIMGYKTWMSMGS---PLPNRMNIVLTSKNIEDQPVFF--EN---TFLCH
--------SESQIFIIGGANLIKQVNHL--VTNVYLTIIDTEVEESEEN------TYEDLGLI--E----S-EYPHNHFKSTFHTF-
>tr|B3FJX9|B3FJX9_9CAUD Dihydrofolate reductase OS=Pseudomonas phage 201phi2-1 GN=201phi2-1p003 PE=3 SV=1
----TSMILARDVQGVIGIDNKLPW-H-PADMALFIAHTK-----G--KAVVMGRKTWESLP--VKPLPGRHNIILTGKPN-DVVQVS-IASSVEDAIAS
---Q---EGADEVVFIGGRSIYDQVVN-Y-VDEIHVSELNLCVESDVDIYAQDF-DLGFASAG--P----L-K--HLLDYIRYARP-
>tr|Q7VQK5|Q7VQK5_BLOFL Dihydrofolate reductase type I OS=Blochmannia floridanus GN=folA PE=3 SV=1
----ISLIAAFTINYVIGRKNIIPW-YFSWDMMWFKYHTM-----Y--KPVIMGRKTFESMN--SKPLPYRLNIVLSKHHI-NNKNIF-IACNP--IQVV
-------QKNDEVMIIGGGLVYNAFMS-Q-CTRMYLTKIDVVYNGDSWFPSYNP--WCVVYNT--N----K-T--YNLNFQILDRT-
>tr|A0A059X2U1|A0A059X2U1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----KYSLVAYDRNRAIGANGGIPW-MMKTDIQFVRQRTT-----G--NALIMGRRTYDSIG---RALPNRQNIVITHR-----PNVT-VVDNLDDAY--
-------EPGRDAYIFGGGEIYKLAND-T-VDEILATEIDTVA-GAAFFPPLS--GWVEVSRE--H----H-A--YPFDFVVYRNP-
>tr|A0A0G1YFK2|A0A0G1YFK2_9BACT Dihydrofolate reductase OS=Candidatus Saccharibacteria bacterium GW2011_GWC2_48_9 GN=UY35_C0001G0050 PE=3 SV=1
----KYILVAYDQNRAIGAHGSLPW-A-KADMRRVRELTT-----G--HAIIMGRKTYDSIG---RALPNRQNIVVAHHPF--AP-IE-VVASLEGAY--
-------LPDRNAVVFGGSQIYELALA-S-VDRILATEIHTIFDGDVFFPIL---SWQEVSRE--H----H-A--YPFDFVVYERR-
>tr|A0A059WYM3|A0A059WYM3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----KIAIVGYDRHRAIGAHGTLPW-G-KTDMRRLREYTT-----G--NAIIMGRKTYDSIG---HALPNRQNIVLTRTPF--AD-VT-VVSTLEEAY--
-------EPGRDAYIFGGAQIYELALA-T-TDEILATEIDMDVEADAFFPVL---EWVETSRE--H----F-A--YPFAFVTYKKS-
>tr|K2BFM7|K2BFM7_9BACT Dihydrofolate reductase OS=uncultured bacterium (gcode 4) GN=ACD_48C00303G0001 PE=3 SV=1
----ITLVAAISKNNCIGVKGDLPW-H-PEDMKRMREITR-----N--KVLIMGRNTWESIPP-RRPLPDRTNVVITRNDA-LPASVE-RFSSIQEAV--
--------KGEEMVSFGGEGVFKEMIAY--ADALEITHIDDTVDCDAYFPE----IWKEVWR----------H--EGFSFVRYERK-
>tr|Q168V7|Q168V7_ROSDO Dihydrofolate reductase OS=Roseobacter denitrificans (strain ATCC 33942 / OCh 114) GN=folA PE=3 SV=1
----ITLIVARAENGAIGRDGTIPWD-IPEDLKFFQRETL-----G--GALIMGRNTWESLP--VKPLPRRFNIVVSNSDI--A--EV-VAPSVETAIKA
-------QDHQRIYGIGGASIYAEMLP-L-AHRLLISEVQLQVPADTFFPHVD-AEWHQIDRR--S----L----PACFVVEHLRR-
>tr|A9E266|A9E266_9RHOB Dihydrofolate reductase OS=Oceanibulbus indolifex HEL-45 GN=OIHEL45_10438 PE=3 SV=1
----LSLIVARARNGAIGKDGDIPWS-LPEDLKFFQRETT-----G--GAIIMGRRTWESLP--FKPLKNRLNCVVSADID--G--VH-VARDPQAALAA
-------EGYRRVYGIGGEGIYRALLP-L-ADRLLVTEVDVEIDADAFFPDFD-NEWIELGNL--C----L----PRAIAREWLRR-
>tr|A0A0Q2UV42|A0A0Q2UV42_9RHOB Dihydrofolate reductase OS=Loktanella sp. 3ANDIMAR09 GN=AN189_11980 PE=4 SV=1
----LTLIVACARNGAIGRDGDIPWH-APEDLAMFQRETT-----G--GALIMGRHTWNSLP--VKPLKNRMNCVVSDSSL--T--EH-VFGDVAAAVYA
-------AGYQRIYGIGGAGIYGALLG-M-ADRLLITRVDLDVPADTFFPDFD-GGWTQIATR--T----L----PACVLHEYLRV-
>tr|F7ZAI2|F7ZAI2_ROSLO Putative dihydrofolate reductase OS=Roseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149) GN=
--------MARAENGAIGRDGTIPWN-VPEDLKFFQRETL-----G--GALIMGRNTWESLP--VKPLPRRFNVVVSNSDT--A--EV-VAPSVKVAIIE
-------HGHQRIYGIGGAAIYQEMLP-L-AHRLLISEVQIDVPADTFFPNFD-AGWKAIDTR--P----L----PACSVHEYLRL-
>tr|A0A073J204|A0A073J204_9RHOB Dihydrofolate reductase OS=Sulfitobacter pseudonitzschiae GN=SUH3_20420 PE=3 SV=1
----ITLIVARDRNGAIGRDGDIPWD-IREDMKSFQRETL-----G--GAIIMGRKTWDSLP--VRPLARRLNIVVSQQVD--A--EH-VATSVGDAVSD
-------LGYNRIYGIGGAGIYTEMLP-L-ADRLMLSEVATEVAADTFFPSVD-DDWRLISTR--H----F----PECELREYLRK-
>tr|K2JFS0|K2JFS0_9RHOB Dihydrofolate reductase OS=Celeribacter baekdonensis B30 GN=B30_05222 PE=3 SV=1
----ITLIAARDRTGAIGKDNTIPWE-APEDLRFFMRETM-----G--GAVIMGRNTWESLP--FKPLKNRLNIVVSKGVD--Y--EH-VFASVEEAIRS
-------EGRARIYGMGGSGIYSAMLP-L-ADRLVITEVDTEVEADTWFPTFD-NAWRVVSRM--V----L----PKCEVVEWMR--
>tr|A0A0P1GWM7|A0A0P1GWM7_9RHOB Dihydrofolate reductase OS=Phaeobacter sp. CECT 5382 GN=dfrA PE=4 SV=1
----ITLIVARDRNSAIGKDNTIPWH-APEDLKAFQRETL-----G--GAIIMGRNTWDSLP--FKPLKNRLNLVVSRADA--A--EI-VCKSVVDAITA
-------QGYRRIYGIGGAGIYREMLP-L-ADRLLITEVETEVEADTYFPQVD-AQWQRSGDV--L----L----PRCVMVEYLRI-
>tr|B6B1Z6|B6B1Z6_9RHOB Dihydrofolate reductase OS=Rhodobacteraceae bacterium HTCC2083 GN=folA PE=3 SV=1
----ISLIVGRDKSGAIGKGNDIPWY-APEDMQFFKRETL-----G--GAIIMGRNTWDSLP--FKPLKDRLNIVVTQGCA--A--EL-TCKSISEAIFS
-------RGFRRIYGIGGAGIYREMIE-L-ADRLLITEVDLEVSADVFFPEVP-ENWQIIGET--R----L----PACSVFEYLRL-
>tr|I7EY62|I7EY62_PHAIB Dihydrofolate reductase OS=Phaeobacter inhibens (strain ATCC 700781 / DSM 17395 / CIP 105210 / NBRC 16654 / BS107) GN=folA PE=3
----ITLIVARDQNGAIGKDNTIPWH-APEDLQSFQRETL-----G--GALIMGRNTWDSLP--VKPLKNRLNLVVSDPEA--A--DL-VYPSIEAALRA
-------QGYHRIYGIGGAGIYKGMME-G-ADRMLITEVETEVEADTYFPKFR-GEWGIASQT--E----I----PACVVVEYLRR-
>tr|B7QY66|B7QY66_9RHOB Dihydrofolate reductase OS=Ruegeria sp. R11 GN=folA PE=3 SV=1
----ITLIVARDQNGAIGKDNTIPWH-APEDLKCFQRETL-----G--GAVIMGRNTWESLP--FKPLKNRLNLVVSDPNA--A--EI-VCPSIEAALRA
-------QGYLRIYGIGGAGIYREMLP-I-ADRMVITEVDTVVDPDTHFPAFS-SEWAIASQT--E----L----PNCVAVEYLRR-
>tr|A0A0P1ES49|A0A0P1ES49_9RHOB Dihydrofolate reductase OS=Shimia marina GN=folA PE=4 SV=1
----ITLVVARAENGAIGRDGDIPWH-IPEDLKTFQRETL-----G--GALIMGRNTWDSLP--VKPLPKRFNIVVSQPDV--A--EC-VAPSVADAVTA
-------QGYDRIYGIGGAGIYREMLD-I-AHRLLITEVAMKVDADTFFPDFD-KNWDVISRR--P----L----IPCEVCEYIRR-
>tr|B6B7G6|B6B7G6_9RHOB Dihydrofolate reductase OS=Rhodobacterales bacterium Y4I GN=folA PE=3 SV=1
----ITLIAARARNGAIGKDNDIPWF-APEDLKAFQRETL-----G--GAIIMGRNTWDSLP--VKPLKNRLNLVVSNPAA--A--DI-VLPSIGAAVHA
-------QGYRRVYGIGGEGIYRGMLG-M-ADRLLITEVDLTIPADAYFPEFD-DNWVKAGET--V----L----PACVMVEYLRR-
>tr|A0A0P1IQG5|A0A0P1IQG5_9RHOB Dihydrofolate reductase OS=Thalassobius sp. CECT 5114 GN=folA PE=4 SV=1
----ITLIVGRDRNGAIGKDNDIPWY-APEDLAFFKQETL-----G--GAVVMGRNTWESLP--FKPLKNRLNIVVSQDGL--G--EV-TVASVEDAVFD
-------AGYQRIYSMGGAGIYKAMLP-I-ADRLLVTEVDVEVEPDTFFPAFF-QDWELTNTR--P----L----PKCTLTEYFRK-
>tr|A0A0C1EUU3|A0A0C1EUU3_9RHOB Dihydrofolate reductase OS=Leisingera sp. ANG-M1 GN=RA19_00660 PE=3 SV=1
----ITLIAARARNGAIGKDNDIPWH-APEDLKAFQRETL-----G--GAIIMGRNTWDSLP--FKPLKNRLNLVVSNPQA--A--ET-VLPSIEAAVYA
-------QGYRRVYGIGGEGIYRGMLA-M-ADRLLVTEVDLTIEADAFFPEFQ-DEWTRAGEM--V----L----PACVMVEYLRR-
>tr|V9VRT7|V9VRT7_9RHOB Dihydrofolate reductase OS=Leisingera methylohalidivorans DSM 14336 GN=METH_06390 PE=3 SV=1
----ITLIAARARNGAIGKDNDIPWF-APEDLKAFQRETL-----G--GALIMGRNTWDSLP--VKPLKNRLNLVVSNPRA--A--GT-VLPSIGAAVYA
-------QGYRRVYGIGGEGIYRGMLE-M-ADRLLITEVDLTVEADAYFPDFR-EEWSKTGET--V----L----PACVMAEYLRR-
>tr|C7D9E1|C7D9E1_9RHOB Dihydrofolate reductase OS=Thalassobium sp. R2A62 GN=folA PE=3 SV=1
----ISLVVARARNGVIGKDNTIPWH-APEDLAFFQRETI-----G--GAIIMGRNTWDSLP--FKPLKGRMNIVVSRDIK--G--VL-TVRSIGAAIQD
-------AGYMRIYGIGGSGIYSEMLG-Y-ADRLLITEVDLEIAADAFFPELG--EWSDVQEI--E----L----PKCVAHEWVRV-
>tr|A4EZL4|A4EZL4_9RHOB Dihydrofolate reductase OS=Roseobacter sp. SK209-2-6 GN=RSK20926_16917 PE=3 SV=1
----ITLIAARDRNGAIGKDNTIPWR-APEDMEAFKRETL-----G--GAVIMGRNTWDSLP--FKPLKNRLNITVSQSDL--M--DL-VCASVEEAIYA
-------HGYRRLYGIGGSGIYRAMLP-L-AERLLITEVETEVEADTYFPEFS-TDWHCIGET--T----L----PACRMVEYVRK-
>tr|A0A0F4RRE8|A0A0F4RRE8_9RHOB Dihydrofolate reductase OS=Ruegeria mobilis GN=TW79_18580 PE=3 SV=1
----ITLIVARARNAAIGKDNDIPWH-APEDLKAFQRETL-----G--GAIIMGRNTWDSLP--VKPLKNRLNIVVSNPDA--A--ET-VVKTIEDAVRR
-------EGYARIYGIGGAGIYKGMLE-I-ADRLMITEVALDIPADAFFPSFD-SQWRIGARL--P----L----PTCVLTEYLRK-
>tr|A0A0P6RJ46|A0A0P6RJ46_9RHOB Dihydrofolate reductase OS=Phaeobacter sp. 11ANDIMAR09 GN=AN476_17330 PE=4 SV=1
----ITLIVARDRNGAIGKDNTIPWH-APEDLKAFQRETL-----G--GAIVMGRNTWDSLP--FKPLKNRLNLVVSSPKA--A--EH-VHASVVEAVYA
-------EGYRRVYGIGGAGIYREMMQ-I-ADRLLITEVGLEVEGDTYFPEIV-GEWQRQGET--L----L----PSCVMVEYLRV-
>tr|A3X8B1|A3X8B1_9RHOB Dihydrofolate reductase OS=Roseobacter sp. MED193 GN=MED193_06114 PE=3 SV=1
----ITLIVARDRNGAIGKDNTIPWH-APEDLKAFQRETL-----G--GAIIMGRNTWDSLP--FKPLKNRLNLVVSNSEA--A--DE-VHGSVAAAVYG
-------QGYRRIYGIGGAGIYREMMQ-I-ADRLLITEVDMVVEADTFFPEVT-SDWQRNGET--Q----L----PACTMVEFLRI-
>tr|I0ALG2|I0ALG2_IGNAJ Dihydrofolate reductase OS=Ignavibacterium album (strain DSM 19864 / JCM 16511 / NBRC 101810 / Mat9-16) GN=folA PE=3 SV=1
----ISLIVAIAQNGVIGKSGEMSW-H-SEEFKHFKNTTK-----G--FPVLMGRKTFETL-G--KPLKERLNIVLTRNPE-KTQDVL-IFSSLDEAI-R
---E---KKFEKIFIIGGAEIYKIAIP-I-VDEMIISRMKFTAEGDVYFPEF---NWKKEKIM--D----K---------EVYLYK-
>tr|R5M3U8|R5M3U8_9MOLU Dihydrofolate reductase OS=Mycoplasma sp. CAG:877 GN=BN801_01222 PE=3 SV=1
----LTLIAAVGKNNELGK-NKLIW-H-PDDMKFFKEQTI-----N--KKIILGRKTLESL-PG--LLPKRIHLVLTHQSL-EKE--K-VYNNIEDLLDT
I--N---E---EVMVIGGAKIYEKFFP-K-ANKVILTEIEDS-SADAYFPKL---DWTRKILV--T----K-G--ITYHHVIYERI-
>tr|A0A0A0C5U4|A0A0A0C5U4_9CELL Dihydrofolate reductase OS=Actinotalea fermentans ATCC 43279 = JCM 9966 = DSM 3133 GN=N867_07605 PE=3 SV=1
----LAAIWAQSVDGVIGRDGGLPW-SLPEDLAHFRALTA-----G--HVVVMGRATWQSLPDAFRPLPGRENVVLSRDLS---AGAT-VVHDVAEAL--
--------GDRAAWVVGGAQVYAETLD----HRVEVTDVDVV--TGVRAPRL--QGWRELAVDPAD----G----LRYRFRSLERV-
>tr|Q6A328|Q6A328_PASMD Dihydrofolate reductase OS=Pasteurella multocida GN=dfrA20 PE=3 SV=1
----YSLIVAIGKHREMGA-NDLLW-H-PRDMQFFKETTT-----G--HAVVMGRKSWESI-PKYRPLPNRLNFVLTRDKN-SAE-----IYDLKEVAEG
--------KNLTCFIIGGAQIYQLALETGLLNEMYVTQVHNTFEADTFFPFV---EWEEEDIL--E----Q-D--KDEKHLYSFNI-
>tr|A0A075IC80|A0A075IC80_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote SAT1000_51_D10 GN=folA PE=4 SV=1
----MAMIVAMDEGGFIGREGRLPW-R-ASDMARFKRLTEGA--GS--NSVIMGRKTWDSLPD-FRPLPERVNIVMSRDTG--AEGAE-TALYVGRAIF-
-------EGSEECWVIGGAQVYEMFLDR--VGEIHVTTVHTND-GDVKFPGW---EWSEEVIE--S----L-E--CPSTYSVWTRS-
>tr|A0A075G651|A0A075G651_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote AD1000_96_B04 GN=folA PE=4 SV=1
----MAMIVAMDEDGFIGRGNQLPW-R-ASDMVRFKALTEGD--GF--NSVIMGRRTWDSLPD-FRPLPERVNIVMSRDTN--AEGAE-TALYIGRAIY-
-------EGSDECWIIGGALVYEIFLDR--VDEIHVTTVHTSG-GEVRFPEW---VWSEEVVE--R----L-E--YPSTYSIWTRG-
>tr|A0A075HHP9|A0A075HHP9_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote KM3_72_A06 GN=folA PE=3 SV=1
----LAMIVAMDDDGCIGRGNELPW-R-SSDMVRFKRLTEAD--GF--NAVIMGRKTWESLPP-FRPLPERLNIVMSRDTG--HEGAE-NALYPGRAIY-
-------DGCDECWIIGGSQIYEMFLDR--VEEIHLTSVHTSQ-GDVSFPAW---DWVENIIE--K----I-E--YNSTYSIWTRR-
>tr|A0A075HEC2|A0A075HEC2_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote KM3_57_B04 GN=folA PE=4 SV=1
----MAMIVAMDEDGFIGRGNQLPW-K-ASDMARFKELTEGD--GF--NSVIMGRKTWDSLPD-FRPLPERVNIVMSRDTN--TKGAE-TALYIGRAIY-
-------EGSDECWVIGGAQVYEMFLER--VDEIHLTTVHTSG-GEVKFPEW---EWSEEVVE--R----A-E--HDSTYSIWTRG-
>tr|A0A075IH65|A0A075IH65_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote SAT1000_53_H10 GN=folA PE=4 SV=1
----MAMIVAMDEGGFIGTGNRLPW-S-ASDMARFKRLTEGN--GF--NSVIMGRKTWDSLPN-FRPLPERVNIVMSRDTN--AEGAE-TALYVGRAIF-
-------EGSEECWVIGGAQVYEMFLDR--VDEVHVTTVHTTG-GEVGFPSW---GWSEEIVE--R----L-E--HESTYSVWTKS-
>tr|A0A075H618|A0A075H618_9EURY Dihydrofolate reductase (FolA) OS=uncultured marine group II/III euryarchaeote KM3_52_A01 GN=folA PE=4 SV=1
----MAMIVAMDEEGFIGRGNQLPW-R-ASDMTRFKSLTEGD--GF--NSVIMGRKTWDSLPD-FRPLPERVNIVMSRDTN--AKGAE-TALYVGRAIY-
-------EGSDECWVIGGAQVYEMFLDR--VEEIHATIVHTDS-GEVRFPDW---EWSEKVVE--R----V-E--FASTYSIWTRG-
>tr|A0A059X9E7|A0A059X9E7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LTIVVAMDRNRVIGKNGDIPW-A-RADMEHFKQFTM-----G--KVVVMGRKTYDSIPA-FKPLSGRENIVLTKNLE-A-L-CA-VFHEVEPV---
-------SVSREVCVLGGAEIYKLFFE-A-TDELIVTEVDTEVLGDTFFPEI---EWDRRVLF--R----Q-Q--FSFTVCQYTRV-
>tr|A0A0L0L8C3|A0A0L0L8C3_9BACT Dihydrofolate reductase OS=Parcubacteria bacterium C7867-006 GN=AB201_02750 PE=3 SV=1
----ITMIVAMARLGVIGKNGNLPW-A-RADMDHFKKVTM-----N--KTVVMGRKTFDSIPA-FKPLPERENVILTRDSN-Q-P-CL-VLHHRDEVL--
-------ELRDEVFIIGGAEIYRLMMP-Y-TSRLIVTHLF-SLIGDTFFPP----NWNAETLF--N----Q-F--FPFSVVEYTRD-
>tr|V4HDU1|V4HDU1_9EURY Dihydrofolate reductase OS=Candidatus Halobonum tyrrellensis G22 GN=K933_10028 PE=3 SV=1
----LVLIVAVADDGVIGADGEIPW-H-PADLAHFEETTT-----G--HPVIAGRRTYDSIVALGGPLPGRTNVVLSRDDPDLPE--V-HAGSVDEAV-E
A-AA---TGAEVAYVAGGAAVYAEFLDRDLVDRMLVTEIPETV-GDTRFPDW---DWRETARE--S------R--DGLEFVTYERA-
>tr|D7WER0|D7WER0_9CORY Dihydrofolate reductase OS=Corynebacterium genitalium ATCC 33030 GN=folA PE=4 SV=1
----LGAIWAQSVDHIIGDGADMPW-HLPEDLKHFKETTL-----G--NPVIMGRRTWESLP--FKPLPSRTNIIISSREA-WSKGAY-VYRDLPDL---
---------DTDAWIIGGAQLYEATLD-E-VDVIERTLIDVSLANAVYAPRIS--DFELVSES--D----W-P--LRYRFQRFKRK-
>tr|A0A059WY95|A0A059WY95_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----KSIVVAYDMERTIGRDNDIPW-A-PADMRHFKELTE-----G--TSVIMGRNTWDSIPE-YRPLPRRQNIVVSLTQQ--FK-AL-AAQSLEEAF--
-------E--HEIMVIGGAQIYAQALP-L-VDRVYATEINTHTEGDTFFPEL---EWYVDEAE--M----H-L--LPYNFFTYLRH-
>tr|A0A0G3HBA7|A0A0G3HBA7_9CORY Dihydrofolate reductase OS=Corynebacterium uterequi GN=folA PE=3 SV=1
----MRAIWAQSTDGVIGDGHSMPW-HIPADLAHFKQVTL-----G--APVAMGRATWESIPPRFRPLPGRENIVLSRASG--AWGAT-VMAGLGDV---
---------PADAWVIGGGQVYEAVAD----DVVELTLVDAE-LTPVYAPAL--SGMAV----TAD----S-P--VRYRFLRYERT-
>tr|A0A0Q6XN09|A0A0Q6XN09_9MICO Dihydrofolate reductase OS=Leifsonia sp. Root4 GN=ASC66_16655 PE=4 SV=1
----VGLIWAE-RGGVIGLDGVMPW-HVPEDLAHFKAMTL-----G---SVVMGRKTWDSIPERFRPFAGRENIVVTRQA----DGAH-VAHSVADAIAS
---L---TPGERVWVTGGAEIYRAAL--GASDRIEVTEIDD---GDTHAPEIGA-GWHV-TA--DP----------PYRFLRYARA-
>tr|U5J9P6|U5J9P6_9CAUD Uncharacterized protein OS=Bacillus phage vB_BanS-Tsamsa PE=4 SV=1
----ISLIACVDMGMGIAD-GNLLF-D-PADLRYFRETTK-----K--QIVVMGRKTWESL-PDKRPLDRRENYVLTRDKD-VAEGAT-VIHSIEEIL--
-------KGKKEVFIMGGGELYKQMMP-H-ADKMYVTHVHNLNIARVFFPNF----WKALTEI--K----H-A--HSFTFATYKRR-
>tr|R4W8B5|R4W8B5_9EURY Dihydrofolate reductase OS=Salinarchaeum sp. Harcht-Bsk1 GN=L593_02740 PE=3 SV=1
----VYLIAAVAANGVIGKDGELPW-E-PEDMAHFKETTT-----G--HPVIVGRRTFENVLALGGPLPGRTNVVLSRSNPDLPDSIV-VAESIDDALAS
A-AA---RGVDRAYVMGGAAVYDALLDR--ADGMVLTEIDEEF-GEPTFPGW---DWVEIDRD--E------R--DGFAFVTYERA-
>tr|A0A0J6DPQ4|A0A0J6DPQ4_9CELL Dihydrofolate reductase OS=Cellulomonas sp. A375-1 GN=CWIS_01480 PE=3 SV=1
----VALVWAQ-ATGVIGADGAMPW-HVPEDLARFRALTG-----G---PVVMGRATWDSLPPRWRPLPGRTNVVLSRQH----GGAT-VCGDLEAAWSA
---V---PGGEQVWVVGGGAVYALAL--PR-DRVELTKIDT---GDTHAPRL-DQEWRL-SA--DP----------RYRFETYRRR-
>tr|F7ZZR8|F7ZZR8_CELGA Dihydrofolate reductase OS=Cellulomonas gilvus (strain ATCC 13127 / NRRL B-14078) GN=Celgi_2060 PE=3 SV=1
----VALVWAQ-PRGVIGRDGALPW-HIPEDLAHFKALTA-----G---PVVMGRATWESLPPRSRPLPGRTNVVLSRTA----GGAS-VATGLDDALAA
---A---AGGDEIWVVGGGAVYALAL--PR-DRIEVTVVDD---GDTCAPHL-PAQWRL-AV--DP----------RYRFQSYRRR-
>tr|A4AHI2|A4AHI2_9ACTN Dihydrofolate reductase OS=marine actinobacterium PHSC20C1 GN=A20C1_01331 PE=3 SV=1
----LGLIWAQ-EGGVIGQGGTMPW-QLPEDLAHFKKLTL-----G---PVIMGRKTWKSLPPRFRPLPGRRNIVVTRQA----DGAE-IAHSVDAARAT
S--V---DDGEIVWVIGGAEIYRATI--AS-HRLEITQIRN---GDTIAPEL-GEQWML-AS--DP----------QYRFERYENH-
>tr|A3TYY0|A3TYY0_OCEBH Dihydrofolate reductase OS=Oceanicola batsensis (strain ATCC BAA-863 / DSM 15984 / HTCC2597) GN=OB2597_15490 PE=3 SV=1
----ITLVVARDRNGAIGKDGGIPWH-LPGDLKMFQRETT-----G--GALIMGRHTWESLP--AKPLNRRLNIVVTRPDT--A--KL-ICETVGEAVEA
-------EGYFRIYGIGGAGIYRDMLP-L-ADRLLVTEVETAVEADTFFPEFD-EEWQETTRA-------T----PGYAVRELIRK-
>tr|A0A0M9EIU9|A0A0M9EIU9_9RHOB Dihydrofolate reductase OS=Shimia sp. SK013 GN=folA PE=3 SV=1
----ISLVVGRAKNGAIGRDGDIPWH-IPEDLRTFQRETL-----G--GAIIMGRHTWDSLP--KKPLPRRFNIVVSQADA--A--DV-VVGSVVEAVRS
-------EGYDRIYGIGGAGIYAEMMG-V-ADRLLITDVDTVIEADTFFPDFD-AEWRLHHER--P----L----PASIVREYLRK-
>tr|B8HHJ9|B8HHJ9_ARTCA Dihydrofolate reductase OS=Arthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / JCM 12360 / NCIMB 13794 / A6) GN=Ach
----IGMIWAQ-SNGVIGRDGTMPW-HLPEDFEHFRRTTE-----G---SVIMGRRTWESLPEPFRPLPGRRNLVITSDP----AGAV-RSSSILNALAG
---Q---PGSDQVWIIGGGMVYREALFLRA-NTAVITLIAD---G-TYAPELGPD-WEM-SA--EP----------RYRIETWTRS-
>tr|C3PEY4|C3PEY4_CORA7 Dihydrofolate reductase OS=Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) GN=folA PE=3 SV=1
----LGAIWAQSLDGVIGDGVVMPW-HVPEDLKHFKEVTM-----G--APVIMGRKTWESLTPKFRPLPGRDNIVLSREPG--EWGAT-VVDNLDAAL--
--------TLDDAWIIGGGQLYSSALD----DTIELTLMGVQDYDAVLAPSV--EEFSL----SAD----S-P--MKYRFLTYDRK-
>tr|S5THT4|S5THT4_9CORY Dihydrofolate reductase OS=Corynebacterium maris DSM 45190 GN=B841_03925 PE=3 SV=1
----LGAIWAQSRDGVIGDGTQMPW-HVPEDLAHFKDITY-----G--APVVMGRRTWESLPEKFRPLPGRENFVVSREPG--EWGAT-VMPSPVD----
--------SGAGAWVMGGARLYQESVE----DVLEVTVMDCEDLDAVRAPAI--DAFEV----SSD----T-P--LRYRFIRYSRI-
>tr|D5NW46|D5NW46_CORAM Dihydrofolate reductase OS=Corynebacterium ammoniagenes DSM 20306 GN=folA PE=4 SV=1
----LGAIWAQSLDGIIGDGKQMPW-HVPEDLAHFKEVTM-----G--SPVIMGRNTWESLPKKFRPLPGRENFVLSRQPG--DWGAT-VLSHLPE----
---------LTEGWIMGGGRLYASTLE----DILEVTLMDVNDYDAVYAPDI--EAFSQ----TAD----S-P--IKYRFISYERK-
>tr|U2GAK7|U2GAK7_9CORY Diacylglycerol kinase OS=Corynebacterium pseudodiphtheriticum 090104 GN=N579_02115 PE=4 SV=2
----LGAIWAQSLDGIIGDGVAMPW-HVPEDLAHFKEITT-----G--APVIMGRKTWQSLPQQFRPLPGRDNYVLSASPG--SWGAE-VIGSLADV---
--------QLHTAWIMGGGKVYEATLG----DRLEITLMGANSYRAVYAPDV--DDFGL----VAD----S-P--LKYRFLTYERK-
>tr|A0A059XC43|A0A059XC43_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ITIIAAVAANRVIGAAGGMLW-R-PADMNHFVELTT-----P--HPVLMGRKTYESIPA-FRPLKDRLNVVITTNTD-TSPGVL-ICSSLDEAL--
-------QYDDNIFVAGGGSIYSQAIDK--TDRLEITEVHQDY-GDVLFPI----NWKEVHR----------H--EGFSFVRYERQ-
>tr|M1NKA4|M1NKA4_9CORY Dihydrofolate reductase OS=Corynebacterium halotolerans YIM 70093 = DSM 44683 GN=A605_04160 PE=4 SV=1
----LGAIWAQSLDGIIGDGSGMPW-HLPEDLAHFREITT-----G--HPVIMGRRTWTSLPERFRPLPGRINYVLTREAG--DWGAR-VVGDLPDPT--
--------DSPEVWIMGGGQVYAATID----DVLEITLVGVQELRAVHAPEI--AEFGM----VSD----T-P--LKYRFLRYERK-
>tr|A0A0F5DAS6|A0A0F5DAS6_CORDP Diacylglycerol kinase OS=Corynebacterium diphtheriae GN=VN94_09530 PE=4 SV=1
----LRAIWAQSTDGVIGDGNDMPW-HVPEDLAYFKATTL-----G--EPVIMGRTTWTTIPERFRPLPGRRNFVLSRAPG--AWGAE-VVTAIPEL---
---------DCDAWIMGGGAVYTSTLP----DEVVITLIDVTPLAAVYAPAL--DSFEV----VEE----S-P--ARYKFQRLRRR-
>tr|S3A4E7|S3A4E7_9CORY Uncharacterized protein OS=Corynebacterium pyruviciproducens ATCC BAA-1742 GN=HMPREF1219_00036 PE=4 SV=1
----MKAIWAQSLDGIIGDGSGMPW-HLPEDLAHFKKSTM-----G--EDILMGRKTWESIG--SRALPGRDNLVLSSREP-WSRGAS-VIHEVPE----
---------AFSGWLIGGGSLYNKLLP-Q-LDEVLVTYVRTRLTSPVTVPDLAS-QFTVAAET--P----W-P--ATYRFVRYTRT-
>tr|I7JVS4|I7JVS4_9CORY Dihydrofolate reductase OS=Turicella otitidis ATCC 51513 GN=folA PE=3 SV=1
----AGAIWAQSLDGVIGDGETMPW-HLPEDLRHFKETTH-----G--HPVVMGRHTWESFPERVRPLPGRRNIILSKEPG--DWGAE-VATSLPE----
---------PLDGWVIGGAGVYARTID----ERLEITLVDARPLSAVRAPAI--TGFRI----ASD----S-P--LRFRFISYRRD-
>tr|A0A0B6TU57|A0A0B6TU57_9CORY Dihydrofolate reductase OS=Corynebacterium marinum DSM 44953 GN=folA PE=3 SV=1
----LGAIWAQSLDGVIGDGARMPW-HVPEDLAHFREITN-----G--HPVIMGRRTWLSLPEKFRPLPGRENFILCREAG--EWGGQ-VINDLPE----
--------DSPEVWIMGGGQVYAATID----DVLEVTLIGARDLLAVHAPEI--AEFGL----VAD----T-P--LRYRFLRYERK-
>tr|D1BJ51|D1BJ51_SANKS Dihydrofolate reductase OS=Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74) GN=Sked_23300 PE=3 SV=1
----VGLVWAQ-RDGVIGAGGTMPW-HLPEDGAHFRRTTA-----G---AVVMGRATWDSLPERFRPLPGRTNVVLTRSP----GGAV-VVGSLDEALAD
---A----APGRTWVMGGGEVYRQAL--AQ-DLLVVTEIDE---GDTRAPEI-GDGWDAGDS--TD----------RFRFVEHRRT-
>tr|A0A0Q6GEW9|A0A0Q6GEW9_9MICO Dihydrofolate reductase OS=Sanguibacter sp. Leaf3 GN=ASG53_06800 PE=4 SV=1
----VGLVWAQ-RGGVIGAGGTMPW-HLPEDGAHFRRTTA-----G---VVVMGRATWDSLPSRFRPLPGRTNIVLTRAP----GGAE-VVGSLEEALAD
---R----SPARVWVMGGGEVYRQAL--AV-DLLVVTEIDQ---GDTYAPEI-GDGWVAGDE--SG----------RFRFVEHRRA-
>tr|A0A059WZU7|A0A059WZU7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LIIIAAIAANWVIGKDNDLPW-YYPEDLEHFKNITT-----G--HPIIMGWNTYVSILSKAKPLPKRMHFVLTSKKA-IKIQVI-FCSSFGEAVEV
--------LDKEVYVIGGEKVFETAIR-D-ANAMEITEIDAEY-GDAFFPKFDK--WNREVRK--R----D-----GFSFVRYTRK-
>tr|A0A060NJQ0|A0A060NJQ0_9BURK Dihydrofolate reductase OS=Comamonadaceae bacterium A1 GN=SRAA_1556 PE=3 SV=1
----LNLIYAR-ANGVIGLHNRLPW-HLPEDLAHFKRHTL-----G---PVLMGRATWDGLPPRFKPLPGRPNLVLTRHPE---RGAL-PCTSLEDALAQ
M--Q---PPPPEVWVIGGAQLYAQAL--PL-SRVLATEIWD---GDAYAPSL-GPEWQE-SR--EP----------RLDFVCYQRQ-
>tr|A0A0N9JFF4|A0A0N9JFF4_9MICC Dihydrofolate reductase OS=Arthrobacter arilaitensis GN=AOZ07_12280 PE=4 SV=1
----LGAIWAQ-NNGIIGAQGTMPW-HVPEDLAHFKRITA-----G---PVVMGRTTWNSFPAKFRPLPGRTNIVLTGQA----EGAV-PASTLDEALRK
---A---EGSEEVWIIGGGKVYAQALPL---DVAVITKLDE---G-TSAPQLSGD-FAI-AT--EP----A-----RYRFETWLRQ-
>tr|E1VYA2|E1VYA2_ARTAR Dihydrofolate reductase OS=Arthrobacter arilaitensis (strain DSM 16368 / CIP 108037 / JCM 13566 / Re117) GN=folA PE=4 SV=1
----IGAIWAQ-ENGIIGANGTMPW-HVPEDLAHFKRTTA-----G---PVIMGRATWNSFPAKFRPLPGRTNLVLTRDV----SGAE-PVSNLEEAIKA
---S---TGGEEIWIIGGGQVYAQALEL---DLAVITKLEA---G-TSAPQLTAD-FAL-TS--DP----S-----RYRFETWLRQ-
>tr|A0A0M4JFC4|A0A0M4JFC4_9MICC Dihydrofolate reductase OS=Arthrobacter sp. LS16 GN=AFL94_12280 PE=4 SV=1
----VGAIWAQ-DNGIIGNQGTMPW-HVPEDLAHFKRITA-----G---PVIMGRATWESFPPKFRPLPGRSNIVLTTRA----EGAL-PVADLGEALKT
---C---EGSREIWIIGGGKVYAQSLQL---DLAVITKLDE---G-TSAPQLPED-FAL-LS--DP----G-----RYRFETWIRE-
>tr|S7W3I7|S7W3I7_9MICO Dihydrofolate reductase OS=Leifsonia rubra CMS 76R GN=ADILRU_0394 PE=4 SV=1
----VGLIWAQ-EGGIIGSEGAMPW-HLPEDLAHFTALTL-----D---PVIMGRKTWESLPKRFRPLPGRRNIVVTRQT----EGAE-VVHTIEEAIST
STTT---TSDAHVWVIGGAQIYSQAL--NY-QRLEITEIRS---GDTRAPVR-GDQWML-VR--EP----------HYRFLRYEVC-
>tr|J7LRG0|J7LRG0_9MICC Dihydrofolate reductase FolA OS=Arthrobacter sp. Rue61a GN=folA PE=3 SV=1
----IGLVWAQ-KSGVIGKDGAMPW-HLPEDLKHFSQLTT-----G---PVIMGRKTWLSFPEKYRPLPGRTNIVVTRNA----EGAV-VVSSLDAALQF
---A---PGGQKVWIIGGGEIFEQSM--GI-NLAVITIIDD---GDTYAPEL-GDDWTF-AV--AP----------NYRFTTWRRT-
>tr|U2A3G1|U2A3G1_9MICC Dihydrofolate reductase OS=Arthrobacter sp. AK-YN10 GN=M707_10285 PE=3 SV=1
----IGMIWAQ-KAGVIGKDGSMPW-HLPEDLKHFSQLTT-----G---PVIMGRKTWESFPDKYRPLPGRTNIVVTRNQ----DGAV-VVPSLDAALQF
---A---PGGQKVWIIGGGEIFEQSM--GI-NLAVITIIDE---GDTFAPEL-GEDWTF-SV--AP----------KYRFTSWRRT-
>tr|A0A0Q5I3G6|A0A0Q5I3G6_9MICO Dihydrofolate reductase OS=Leifsonia sp. Leaf325 GN=ASF62_03575 PE=4 SV=1
----LGLIWAQ-SDGTIGRDGVMPW-HLPEDLAHFKQVTL-----G---PVVMGRKTWDSLPPRFRPLAGRRNVVLTRQR----DGAE-TAHSIAAAIAE
P--V---AAPQRIWIIGGAELFAALI--ER-DVLEVTEIDS---GDTQAPLI-GAAWSA-VT--DP----------QYRFLTYTRG-
>tr|A0A0Q8CN26|A0A0Q8CN26_9MICO Dihydrofolate reductase OS=Leifsonia sp. Root60 GN=ASD61_01880 PE=4 SV=1
----LGLIWAQ-SDGTIGRGGVMPW-HLPEDLAHFKEVTL-----G---PVVMGRKTWDSLPPRFRPLAERRNIVVTRQH----DGAE-VAHSIEDALAA
SDGS---PLPSRIWIIGGAELFASVI--DR-DVLEVTEIDA---GDTQAPLI-GDAWAA-AT--DP----------QYRFITYARR-
>tr|U3GW69|U3GW69_9CORY Uncharacterized protein OS=Corynebacterium argentoratense DSM 44202 GN=CARG_02715 PE=3 SV=1
----LRAIWAQSIDGVIGDGREMPW-HVPEDLAHFKSTTL-----G--CPVVMGRGTWESLPERFRPLPGRPNYVLSRESG--RWGST-VFSSVDAAL-A
Q-SA---QDGPVLWVIGGGKLYSSTLD----QEVVVTSIDVD-LSLVHAPDV--QDFSL----VEA----S-P--LRLRFERWARS-
>tr|A0A0N1SKG3|A0A0N1SKG3_CORPS Dihydrofolate reductase OS=Corynebacterium pseudotuberculosis 267 GN=folA PE=3 SV=1
----LRAIWAQSRDGVIGNGSDMPW-HLPEDLAHFKKTTL-----G--CPVIMGRKTWESLPPTFRPLPGRQNYVLSSAAG--PWGAC-VVSTLPDV---
---------T-GAWIMGGGQIYDATLP----KEVVRTAVDVEHLSAVSAPAL--SEFEI----VSE----T-P--LRYKFQSLRRT-
>tr|A0A059X2V1|A0A059X2V1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----FSIVVAADAARGIGKGNALPW-KLPKEMAYFKRLTSEAKGFG--NAVVMGRKTYESIPSKFRPLKDRLNVVLSRDPR-VADGAR-ACGSLDQALAG
---E---ANLDQVFVIGGGSLYAEEHP-R-CARVYLTRVHRTF-CDTFLSAFE--NFHLLTSD---------D--VEFTFEVYERS-
>tr|B9YC91|B9YC91_9FIRM Dihydrofolate reductase OS=Holdemania filiformis DSM 12042 GN=folA PE=3 SV=1
----ITMIAALDEVGGLGKAGRMPW-H-PADLRQFQAYTM-----G--KPLLMGRKTAEPL---RRRLLGRQLIIQSRTMK----DFP-VVRTVNEALAA
-------PEFDELVIGGGGEIYALWLPY--AAHLRISRIAGRF-CDTFFPKW---EWICRKQS--E----E-G--FLLEE--WDRT-
>tr|A0A0R0M6G2|A0A0R0M6G2_9NOST Dihydrofolate reductase OS=Cylindrospermopsis sp. CR12 GN=ASL19_15385 PE=4 SV=1
----ISLIAAISQDRILSDSGGIPW-D-PSDGRYFKETTW-----R--HPVIMGRKTYATF---NHPLPNRTNIIVTKNTD-QAPGCV-VFHSLEEAIKM
---S----ETEEIFIAGGEQIYTQAME-F-ANKLYLTIVEGNFEGDIHFPEF----FGKLTKE--E----K-G--FKFKFIEIERQ-
>tr|A0A059WME0|A0A059WME0_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IKFIAAIDDKRGIAKSGIIPWK-LPGDHKYFMDKLH-----D--GPVLSGWNTFRANGL---PFGVGANYILTRKDTESYPGVW-IIHD--EFF--
--------NVDDVWVAGGGQVFAEALPH--ATHLYLTRVSGDFDCDVFFPSF-E-REEPELV----------G--IKYKYQVWVRR-
>tr|K9ZBL4|K9ZBL4_ANACC Dihydrofolate reductase OS=Anabaena cylindrica (strain ATCC 27899 / PCC 7122) GN=Anacy_0527 PE=3 SV=1
----ISLIAAISENRILADSVGIPW-I-PTDERHFQEITW-----R--HPVIMGRRTYSTF---YQPLPNRTNIIVTRNLD-QAPGCV-IFYSLLEAVKM
---S----ETEEIFIAGGGDIYTEAIK-F-ADKLYLTIVEGNFEGDIYFPEF----FGKVTKE--E----H-G--FKFKFVEMERV-
>tr|D7DVX3|D7DVX3_NOSA0 Dihydrofolate reductase OS=Nostoc azollae (strain 0708) GN=Aazo_1890 PE=3 SV=1
----ISLIAAISENRILADSVGIPW-D-PSDLQHFQKKTW-----R--HPVILGRKSYAAF---NHPLPNRTNIILTRSHD-KAPGCL-VFYSLSEAVKM
---S----EKEEIFIAGGGEIFAEAIK-F-ANKLYLTIVEGNFEGDVYFPEF----FGTVTKE--E----H-D--FQFKFVEIERF-
>tr|A0A0P0GA43|A0A0P0GA43_9BACT Dihydrofolate reductase OS=Candidatus Xiphinematobacter sp. Idaho Grape GN=dfrA PE=4 SV=1
----MKAIVAIAENRIIGYRGGIPW-K-PEDLRFFREITW-----G--TTVIMGRKTYDSIG---HPLPGRLNVVLTRKRF-AGD--L-CFSDLKAAVKQ
A--E---KGGREVFVVGGACIYQALLPF--CSEILITHVKGYDSGDTFFPPF---EFSTKAFI--------------MRIIRYLRG-
>tr|A0A0L0KN56|A0A0L0KN56_9ACTN Dihydrofolate reductase OS=Streptomyces acidiscabies GN=IQ63_05535 PE=3 SV=1
----VSAIAALGGNVIGGPDGGMPW-R-PEDSRRFRRITM-----G--HPVIMGRVTFAEF---EKPLDGRLNIVVTRNRS-APEGCV-VTHSLSDALH-
-------RDHEEIFIGGGEFIYREALDH--CNRLYLTLINADFDGQARFPDY---GTEI-ERS---------T--YQYDFVTLEEP-
>tr|T4NEN6|T4NEN6_PEPDI Dihydrofolate reductase OS=Peptoclostridium difficile P28 GN=dfrA PE=3 SV=1
----ISIVVAMDANQLIGANHKMPW-H-PADLAHFRQLTL-----H--HHLLMGRVTYEHL---PKRLDHRILHVAGHKPL---SDV----LPCSDVQRE
---W---KKEEVLYVCGGAQIYAAAIA-Y-ADELWITRIEQSYTGDTWFPAF---DFRLLSNE--Q------K--EGCSIMHYRRR-
>tr|A0A0F4LWB0|A0A0F4LWB0_9LACO Dihydrofolate reductase OS=Lactobacillus mellifer GN=folA PE=3 SV=1
----LAFIWAQDQTGLIGQAGHLPW-HLPADLHYFQQTTL-----H--KTIVMGRKTFMSFP--HGALPQRRNIVLTHQ-AIW-P-VE-IIHQPAALCV-
-------SFKEPIFIIGGRQVFAEFID-Q-VQYLYVTQIHHTFAGATYMIP----QFALVSHH--Q----G-P--WPHDFLIYQRR-
>tr|R6SAX6|R6SAX6_9FIRM Dihydrofolate reductase OS=Eubacterium siraeum CAG:80 GN=BN788_01298 PE=4 SV=1
----MEIIVAVDENYGIGKDGDLLAH-LSPDLKRLKAMTV-----G--NIIVMGSKTYMSFP--KRPLPDRENLIITHHPENYP-GIK-CFTGVDEFLKT
----------KPIFVLGGGSVYEQLLPY--CEKAHITKILHSFEADTFFPNLDNPDWEKESEEEI-----VTGEKYPFRYVTYVRR-
>tr|A0A088TNW4|A0A088TNW4_9MOLU Dihydrofolate reductase OS=Mollicutes bacterium HR1 GN=dfrA PE=3 SV=1
----VNLIVAIGKNNVIGK-NKLPW-H-KEDMKYFKKTTT-----N--QTVIMGEETFKSILSIDKPLPNRTSVIATL--S---YGVE-TTNDIIKYLPK
---------DKEIFIIGGKIIYDLTLD-I-ADRLYITHIDKEY-GDVFFKTI---KYNKIMEN--I----I----GELNFSIYERR-
>tr|A0A094ID62|A0A094ID62_9MOLU Dihydrofolate reductase type 3 OS=Mollicutes bacterium HR2 GN=dhfrIII PE=3 SV=1
----VNLIVAIGKDNLIGK-NMLPW-H-KEDMKYFKEMTM-----G--KKVIMGELTFKSIISINKPLPGRTSIIATL--T---YGIE-ITNDIISYLPK
---------DEEVFIIGGKIIYDLTLD-L-ADKLYITHVNKEY-GNVYFKNI---KYNKVSEK--I----S----GDLNFSVYERI-
>tr|E2SJC1|E2SJC1_9FIRM Dihydrofolate reductase OS=Erysipelotrichaceae bacterium 3_1_53 GN=folA PE=3 SV=1
----ISIVAAMDPNCLIGRNHSMPW-S-PADLAHFRQLTL-----H--HHLLMGRRTYEHL---PKPLDQRVLHIASRTPL---SHI----QSCTDADQE
---W---VKEETLYVCGGAMIYACALP-Y-ADELWITEIEQTYEEDTWFPAF---AFLVVSKE--Q------K--EGCIVIHYRKR-
>tr|U7V996|U7V996_9FUSO Dihydrofolate reductase OS=Cetobacterium somerae ATCC BAA-474 GN=HMPREF0202_02370 PE=3 SV=1
----LSLIVAMDENNLIGN-NCMPW-D-PEDLNLFKEITS-----N--SIVIMGRKTFQSI-G--RPLPNRINFVLTKDKN-FHK--Q-IFNCALKKA-Q
---K---ITNKKIFIIGGKTIYEYFLP-L-INEFHFSYIKGKFFGDTFFPEI---NFYIANTR--E----F-----DFIYIHYIKN-
>tr|R5G570|R5G570_9FIRM Dihydrofolate reductase OS=Coprobacillus sp. CAG:698 GN=BN756_01301 PE=3 SV=1
----ISLIFAMDINNLIGK-NDLPW-H-SEDLKYFKAVTS-----G--KKVVMGENTFFSIVNIGKPLTNRENYVATLA-N---FNVN-VINDLISFLKD
--------VSEEYFIIGGKRIYELSLP-Y-ADRLYITHINREY-GNVYFPKI---EYKKIKSN--K----I----DELDFCVYERI-
>tr|A0A0B3W4E5|A0A0B3W4E5_9FIRM Dihydrofolate reductase OS=Terrisporobacter othiniensis GN=QX51_09205 PE=3 SV=1
----ISLIVAATENNAIGK-NKMLF-H-KEDLLFFKNTTI-----N--KTIVMGRKTFESL-P--GVLPFRKHIVLSRDKG-NVE--E-INHSLEEVLKF
--------SKEEIFIIGGEEIYRQILEKNLADKIYITRIYKTVEADTFFPKI---KFQIVDKK--V----L-N--KEAIVYVYENI-
>tr|A0A0G9GIE0|A0A0G9GIE0_LACPN Dihydrofolate reductase OS=Lactobacillus plantarum GN=WP50_36680 PE=3 SV=1
-------MLAEDQNGLIGNQGQLPWH-LPADMQRFKALTT-----G--HHVVMGRKTFAGF---KRPLPRRTNWVLSRQSDLLPPEVH-QLADVAAIQ--
-------HPDEPIFVIGGAVVFEAVLS-V-ADYLYRTRINARFDGDTWMPAV---QWQLVSQQ--I----G-Q--YPYEFDDFRRR-
>tr|A0A0R2AI27|A0A0R2AI27_9LACO Dihydrofolate reductase OS=Lactobacillus vaccinostercus DSM 20634 GN=FC26_GL002098 PE=4 SV=1
----IAFVWAEELNGYIGNHGDLPWH-LPADMARFKRVTI-----G--HTVVMGKTTFNSMH---RPLPKRRNVILSTS--MVQDGIE-VVRSVAELQ--
-------NTDDDIYIIGGAKVFESTQA-I-VNCLIRTVIEKSYKGDTKMPPI---NWRLVKSD--H----F-E--AAYRFETWCKL-
>tr|A0A0R2BS82|A0A0R2BS82_9LACO Dihydrofolate reductase OS=Lactobacillus dextrinicus DSM 20335 GN=FC84_GL001360 PE=4 SV=1
----LAFIWAEDQQHLIGDHGQLPW-H-PADLKHFQALTV-----G--QTIIMGRKTYDSFP--NGPLPRRQNWVLTTQAA-FPDSVR-VFNQITAIRAA
-------APEQNYLVIGGVSLFETFVD-S-VDVLYQTTIKASYQ-DVYMPTLPW-KFNLVKQQ--V----H----PEFSFNEYHRG-
>tr|A0A0R1W1E6|A0A0R1W1E6_9LACO Dihydrofolate reductase OS=Lactobacillus suebicus DSM 5007 = KCTC 3549 GN=FD16_GL000661 PE=4 SV=1
----IGFIWAEDLDGNIGSNGQLPWH-LPADMARFKKLTT-----G--HTIVMGKATYESMK---RPLPKRRNIVLSSS--LERDGIE-IVRNISELS--
-------GIDDDIYIIGGAGVFNSTVS-M-ADHLFRTVIESRYNGDTKIPPI---NWRLIEQF--D----H-E--SGYRFETWQKL-
>tr|A0A0D0Y423|A0A0D0Y423_9LACO Dihydrofolate reductase OS=Lactobacillus wasatchensis GN=WDC_1387 PE=3 SV=1
----ISFIWAEDLDGTIGKNGQLPWH-LPADMRRFKEFTT-----N--HTIVMGKRTYESLK---RPLPQRRNIVLSNA--LPIDGVE-IVRDAAELE--
-------SLTDDVYIIGGAIVFSTTFG-W-VNQLIKTVVSGHFAGDTKMIPI---KWQLTDRT--E----Y-K--YDYAFETWHRK-
>tr|K8ZL19|K8ZL19_9ENTE Dihydrofolate reductase OS=Catellicoccus marimammalium M35/04/3 GN=C683_0604 PE=3 SV=1
----MKAIWAEDNQGWMGY-GKLPW-H-PEDLRFFKEKTS-----G--NIVIMGRKTWEGI-G--HPLPNRVNIILSRTEK-IP-GCL-TFSSIKEVL-Q
---D---KKEVEVYVIGGKEIFEQFFP-Y-CHTIYRTIIHHSYPGDVQAPHI---QWERVEVK--E----E-Y--PQITFETWQRK-
>tr|A0A0M9D457|A0A0M9D457_9LACO Dihydrofolate reductase OS=Lactobacillus apinorum GN=RZ74_06920 PE=3 SV=1
----ISFLWAESNNHIIGLNGDLPWH-LPADMKYFKETTT-----H--QIIMAGRTTYESF---KRPLPNRLNTVLTSHDKSYPDDVV-VFNELSEFL--
-------FSDKEIFVVGGAKIFSELTE-Y-VDRLYKTVIDYDFDGDTKMSEI---DFNLVSTK--E----G-I--YPYRFEVYERK-
>tr|R4PLX3|R4PLX3_9BACT Dihydrofolate reductase OS=Candidatus Saccharimonas aalborgensis GN=L336_0949 PE=3 SV=1
----KELIVAYDQKRGIGADGDLLW-Q-PGDLAHFKQMTM-----G--SSLVMGRTTYESIG---RPLPGREMIVVTHRPL--DE-II-AVHSLAEAY--
-------SRER-TVVIGGGQIYEQALREGSIERIHATEVTATFPATVFFPVL---MWHETTRE--H----H-R--YSYDFVTYERR-
>tr|R5T096|R5T096_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:1219 GN=BN478_00453 PE=4 SV=1
----FTIIAAVGKNLELGKNGGLIW-SLPNDLKFFKEKTT-----G--KKVFMGLNTFRSLPK---KLPNREHYVLTDVKF---DDIN-QVFNLEEFIKD
--------TKEEIFVIGGGMVYRQMLP-Y-SKKMYLTEIDAICNAQVYFPNFDK--FERNELY--K----N-G--INYTHVEYIRK-
>tr|K9EDP1|K9EDP1_9LACT Dihydrofolate reductase OS=Alloiococcus otitis ATCC 51267 GN=HMPREF9698_00446 PE=3 SV=1
----IAYVWAQDEQGIIGKDKVLPWE-LSNDLKHFKKVTE-----G--HTILMGRKTFEGMD--KKPLPNRKTLVLTRQDDYAGDQVE-VVHSKDQAL--
-------GHGVDLYVIGGAGIFDLFLD-Q-VDVLHQTVIHESFDGDTTMPDI---SFNQVSKA--Y----Y-N--HSHTIYEYRRK-
>tr|A0A0E9EZL3|A0A0E9EZL3_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_7 PE=3 SV=1
----LIYIWAQDENGVIGKEGVLPWY-LPNDLKFFKEVTL-----D--QTIVMGRNTFEGMG--KRILPRRHSIVVSNVADYANG-AE-VITDVETLI--
-------AKHEDIYIIGGAVLFDSLKH-Q-VNILYCTKIHEQFDGDTYFPQF---KFVKVKSM--N----G-I--YPHTFEIYQKI-
>tr|K1Z5J9|K1Z5J9_9BACT Dihydrofolate reductase OS=uncultured bacterium (gcode 4) GN=ACD_71C00004G0001 PE=3 SV=1
----YILIAAMADNRVIGN-WQLPW-H-PEDLQNFKRLTT-----G--GVIIMGRKTYESI-G--RPLPNRRNIVLSSQG---IEGIE-AFPTIPEML-E
---N---EWIDKVFIIGWQKIYEEFLKMQLVDEVWLSKIPGHYEGDVFLAEFEK-NFEKQKVE--Q----F-----TFQFIRYRKK-
>tr|A0A059XE62|A0A059XE62_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ISFIAAITKNHVMAK-GGLPW-E-KTDKEYYHAKVR-----G--HIAIVGSTTFPQL-N--EGLTDREIIVLAHDLD-HPA--T-VVHSVDEAL--
-------HTTEEIMVLGGGQVFKGMMP-Y-ADRMYLTEIDIELDGDVFFPEF---EWIETSRE--H----H-E--YDFDFVVYDRR-
>tr|Q14P23|Q14P23_SPICI Dihydrofolate reductase OS=Spiroplasma citri GN=dfrA PE=3 SV=1
----IKLLWAMDENNLIGQNDQLPW-HLREELQHFKETTL-----G--QTILFGRLTYEGIG--W-PLPKRKTLVLTRHLDYIKHDVE-VVTDLTAIIHQ
-------NPTEDIYICGGKKIYEATLP-Y-ADELIISLIKGKYQGDTYFPS----QFTLIKLN---------E--YQQFVIKYYKR-
>tr|A0A059XEW7|A0A059XEW7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LSAVVAASDNDVIGNKGDIPW-S-KGEQARVKQISM-----G--KPLIMGRKTHDS---IGRSLPGRLNIVISRNPN-VHD--V-LVGSLDEALA-
-------ASADEVIIFGGQKIFEAAMPL--LGRIYLTRVHANF-GYSWFKFN---QWKVISEE--R----H-P--YDFDYLLLERK-
>tr|E3PVD8|E3PVD8_CLOSD Dihydrofolate reductase OS=Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654) GN=CLOST_2476 PE=4 SV=
----IIIAAMRDYDSAIGYQGNLLYD-IKEDLNYFKEITY-----N--NIVIFGSSTYIKLPH---PLIGRDNFVLSRKDIDYGVKLK-NIE----EVAK
--------PDKKVFICGGESVYKSFLDY--SHEIYLTIIKTNDTKIADTH---F-NWKMISVR--A----D-KYP--HYFCKYRKK-
>tr|A0A0R2D081|A0A0R2D081_9LACO Dihydrofolate reductase OS=Lactobacillus senioris DSM 24302 = JCM 17472 GN=FC56_GL000536 PE=4 SV=1
----ISFIWAEDLNGLIGKNNHLPWR-LPADVKYFKDTTM-----G--HPLVSGANTFKSY---PGVLPGRQNIVLAQN--DFPEEVT-VVHELEQLL--
-------DPETEYFISGGATVFKQLLP-Y-VDRLYVTTINDTFIGDTFMPVI---EFELLSKQ--E----F-P--YNYQFEVYQRI-
>tr|A0A0R2D4T8|A0A0R2D4T8_9LACO Dihydrofolate reductase OS=Lactobacillus rennini DSM 20253 GN=FC24_GL000765 PE=4 SV=1
----IAFMWAEAKDHVIGAAGQLPWH-LPADMQHFKTVTQ-----Q--QIVVMGRRTYASIG---KALPNRTNIVLSHQAKPVAPSVL-VMHQRQEVL--
-------HPQQETIVIGGAQIFSLFKT-D-VTKLYVTRIHAKFSGDTYMPAL---TFTRQWQQ--V----G-H--YPYVFECYQRK-
>tr|A0A0R1F1W0|A0A0R1F1W0_9LACO Dihydrofolate reductase OS=Lactobacillus coryniformis subsp. coryniformis KCTC 3167 = DSM 20001 GN=FD22_GL001551 PE=4 SV=1
----IAFMWAEARDHLIGANGHLPWH-LPADLQHFKQTTL-----N--QIVVMGRKTYAGM---GKPLPGRTNIVLSQQVDYVAPGVI-LLNNVAAVL--
-------HPQQETIIIGGAQIFALFKE-Y-VTRLYVTEIDATFSGDTYMPAL---AFKRVAFQ--A----G-K--YPYSFATYQRR-
>tr|D5V6S5|D5V6S5_ARCNC Dihydrofolate reductase OS=Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 7604 / NCTC 12251 / CI) GN=Arnit_2697 PE
----VSMIVAYGKNWEIGL-NQMLW-H-SEDFKNFKTITS-----G--HHLLMGRKTFESI-G--KPLPNRTSLVLSNGD---FEGVH-SFNDIHEAL-R
---Q---RGEEELFIIGGATIYKTLFD-Y-VDKMYLSEVDYSGEADAYLEEI---TWDLAQQK--D----Y-S--PAWKFKVWVKR-
>tr|F4KVT6|F4KVT6_HALH1 Dihydrofolate reductase OS=Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O) GN=Halhy_5688 PE=3 SV=1
----KTIIAAKSDNNAIGIKQTLPW-H-PADIKFFLAQIQ-----N--GYLLTGRNSYLTPEG-GLFAKRKDVIVVTRQKD-AA-NAN-VVHSVEEAFE-
-------LGVQQLNILGGAEIYAQTIHL--ADEMIITEIHAIC-GDTFFPEI---FWKETKRE--D----H-P--HPYSFVWYQPI-
>tr|U2QUG6|U2QUG6_9BACL Dihydrofolate reductase OS=Gemella bergeriae ATCC 700627 GN=HMPREF1983_00277 PE=3 SV=1
----ISLVVAYDKEKGIGN-NTIPW-R-KNDMLRVKELTT-----G--QTIIMGRKTLESI-G--RALPNRVNRVLTRNPE-LGDNIE-V---FSDDK-E
---N---IKTKNVFIFGGGAIYNKYFD-I-CDEMFVTEVETVANTDTKFPDF---EWELIEKK--D----F-E--FDYSFLHYKRK-
>tr|H7FXZ3|H7FXZ3_9LACO Dihydrofolate reductase OS=Lactobacillus salivarius SMXD51 GN=SMXD51_05048 PE=3 SV=1
----ISFVWAEDQKHQIGYKGHLPWRRLPADLAHFKKVTM-----G--HPMVMGKKTFDSFP---GLLPGRKHVVLTHDTTLEKYQVK-ILNSIDELT--
-------NQSQEVSVIGGAMLFKLLLN-K-VDKLYKTEILSEFDGDTVMPTI---EFKLISQK--I----G-I--YPYIFLEYERK-
>tr|K0NQQ8|K0NQQ8_9LACO Dihydrofolate reductase OS=Lactobacillus equicursoris 66c GN=BN146_08835 PE=3 SV=1
----LTYVWAQDEAGAIGKDGILPWH-LPADLKHFKEVTM-----G--HAMLMGKKTFDSFP---GLLPGRKHVVLTHHEI---AKVE-VLHGEADLK--
-------HEAEEVCVIGGASLFELLKD-R-VDCLEVTKIKGTFPADTYMPDL---AFSLDKEE--K----H-K--YDYVFQRWLRK-
>tr|R5PB05|R5PB05_9BACT Dihydrofolate reductase OS=Prevotella sp. CAG:1092 GN=BN465_02444 PE=4 SV=1
----LKIIVAVANNNAIGNKGKLLY-TLKDDMKYFKAKTN-----N--NVVIMGRKTFESIGK---PLSNRVNIVLSSNKI-PDV----LESAVSFAT--
--------RDKKIFVIGGGKLYKEALDKNYVDEIFLTKIYATPKADVFFPSLDL--WEVIKCY--E----K-E--YNYSIIRIKS--
>tr|A0A0R2CYK3|A0A0R2CYK3_9LACO Dihydrofolate reductase OS=Lactobacillus aquaticus DSM 21051 GN=FC19_GL000617 PE=4 SV=1
----LAYIWAEDEKRHIGYQGRLPWR-LPADLAYFKEKTL-----N--HPIIMGRKTFESFK---GFLPRRHHIVLTSSKDFEKYRLT-VVHSIPELR--
--------REELLFVIGGASLFGELLD-D-VDFLYVTKINALFKADTSMPKI---KFELITKI--D----G-L--YDHRFEVYQRR-
>tr|A0A0R1Q131|A0A0R1Q131_9LACO Dihydrofolate reductase OS=Lactobacillus uvarum DSM 19971 GN=FD20_GL001607 PE=4 SV=1
----LAYIWAEDEKHHIGYEGHLPWK-LPADLAYFKEKTL-----D--HTIIMGRKTFESFK---GFLPRRHHIVLTTSKEFKKYRLT-VVHSISELR--
--------KDELLFVIGGASLFEKLVD-D-VDFLYVTKIKAVFKADTSMPEI---EFELIATT--D----G-L--YDHQFKVYQRK-
>tr|D0DF62|D0DF62_9LACO Dihydrofolate reductase OS=Lactobacillus crispatus MV-3A-US GN=folA PE=3 SV=1
----LSFVWAEDQQHGIGIDGHLPWH-LPADLKHFKEKTI-----G--HPIIMGRKTFASLP---HLLPERKHIVLTHRQELQKYQVK-IVSTLAELN--
-------HQTEEICAIGGVSIFRALLD-Q-VDLLEKTEIKANFKTDTVMPAI---DFELVSRE--E----H-K--YDYTFLSYHRK-
>tr|A0A0R1YIM9|A0A0R1YIM9_9LACO Dihydrofolate reductase OS=Lactobacillus aviarius subsp. aviarius DSM 20655 GN=FC33_GL001395 PE=4 SV=1
----LAYIWAEDLTGGIGVDGHLPWH-LAADLKRFKEKTM-----N--HPMIMGRRTFESLP---GILPGRKHIVLTHSNLD--SNVK-VVHSKEELD--
-------QDNQLNVIIGGATLFKMYRD-Q-VDILYQTIVKDNFQTDTQMPAI---DFEKVEDQ--R----F-N--LKYEFVTYRRK-
>tr|A0A0R1U886|A0A0R1U886_9LACO Dihydrofolate reductase OS=Lactobacillus kalixensis DSM 16043 GN=FC46_GL000770 PE=4 SV=1
----ISFVWAEDENHGIGLDGHLPWH-LPADLHHFKEKTM-----G--HPILMGRKTFASLP---HLLPGRKHLILTHDKKLVEYQVL-IFANMQEIQ--
-------HKDEEICAIGGVSIFNFLKN-Q-VDVLEKTEIYHSFKVDTFMPEI---QFELVQRE--D----F-K--YDYSFLTYKRI-
>tr|C2EMP9|C2EMP9_9LACO Dihydrofolate reductase OS=Lactobacillus ultunensis DSM 16047 GN=folA PE=3 SV=1
----IEYVWAEDKKHQIGVDGHLPWH-LPADLKHFKEETI-----N--HPIIMGRKTFASLP---RLLPKRKHIVLTHNEDLKKYQVI-ILASLEELN--
-------HRSEKICAIGGVSIFKALID-Q-VDILAKTEIDGVFSADTVMPEI---KFKLIKKE--A----H-K--FPYTFLTYVRK-
>tr|A0A0R1HF08|A0A0R1HF08_LACAM Dihydrofolate reductase OS=Lactobacillus amylovorus DSM 20531 GN=FC63_GL000009 PE=4 SV=1
----IEYVWAEDKKRQIGVDGHLPWH-LPADLKHFKEKTI-----D--HPILMGRKTFTSLP---KLLPRRKHIVLTHSEELAKWQVE-ILTSIEEMN--
-------HQAETICAIGGVSIFKALLD-Q-VDVLEKTEIDGIFRADTVMPEI---RFKLVHKE--P----H-K--YPYTFLTYVRK-
>tr|A0A0F4LVE2|A0A0F4LVE2_9LACO Dihydrofolate reductase OS=Lactobacillus apis GN=folA PE=3 SV=1
----ITFIWAEDEQHKIGLDGHLPWY-IPEDLKHFKTLTI-----N--HPIIMGRKTFNSLP---RILPQRRHIVLSQNQVFEEYQVV-VVSSINSLN--
-------HQTEQLYVIGGVSVFEALKD-R-VDCLEKTAIAATFPADTVMPDL---DFQLSKKV--H----H-Q--YSYDFLTYLRK-
>tr|A0A0L7DPT3|A0A0L7DPT3_CLOBO Dihydrofolate reductase OS=Clostridium botulinum GN=ADU76_07855 PE=3 SV=1
----ISFVVAVDKNNLIGKNNTLPW-HLPCDLKHFKEITLK---ES--KTIIMGRKTFEALP---NILPGRKHIILTRNQN-VNNNVE-IIYNISQLT--
-------KSHKEYFVIGGGKIFSMLLP-Y-ATKIYMTKINDSFDGDTFFPKLD-GQWQIVESF--N----G-I--YEHSFLTLYKK-
>tr|A0A072YUS0|A0A072YUS0_CLONO Dihydrofolate reductase OS=Clostridium novyi B str. NCTC 9691 GN=Z958_08940 PE=3 SV=1
----LSFVVAIDKNNLIGKNNKLPW-NLPCDLNHFKEITLK---ES--KTIIMGRKTFETLP---NILPGRKHIILTENQN-INNNVE-VIYNITKLT--
-------KSHKEYFVIGGGKIFSLLLP-H-ATKIYMTKINHSFEGDTFFPELD-TKWEITECI--H----G-I--YKHTFLTLCKK-
>tr|A0A0M0GDI3|A0A0M0GDI3_SPOGL Uncharacterized protein OS=Sporosarcina globispora GN=AF332_12015 PE=4 SV=1
----INIIAAMGLDRELGQ-NQLLC-N-SADLKHFKELTT-----G--GFVLMGSNTFRSI-GK--SLPDRENIVLTRDTK-LPA--F-AYDSFDQVLRN
F--N---EEVDDLWIIGGSNVYSQAIQ-H-ADKMYLTVIQNRFPADCYFPAF---DWNHKVTG--F----K-D--FDHYYVEYSRK-
>tr|D5T4G3|D5T4G3_LEUKI Dihydrofolate reductase OS=Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25) GN=LKI_09475 PE=3 SV=1
----IKMVWAEDREHAIGKNGNLPWR-LPDDLKLFREETT-----N--TLMIMGRTTWSSIG---RPLPNRQTLVLTRQADWIPFDVL-VTHSVAETL--
-------AESKDVAIAGGAAIYRAFMP-Y-ATDLIVTRIDGIINGDTFVDAI---TFELVSRQ--P----H-D--YAFVVERYKRR-
>tr|C2KKL3|C2KKL3_LEUMC Dihydrofolate reductase OS=Leuconostoc mesenteroides subsp. cremoris ATCC 19254 GN=folA PE=3 SV=1
----IKMVWAEDRQHAIGKDGGIPW-H-PDDLKLFRDETV-----N--TLMIMGRPTWVSI---GRPLPKRTTVVMTRQED---PEVK-VIHSIEEAKAK
---E-----ERDITIAGGAAVYREFMP-Y-STDLIITRVDGVIDGDTFVDEV---QFQLKSSE--P----H-D--YAFVVERYERI-
>tr|A0A062XKI8|A0A062XKI8_LEUPS Dihydrofolate reductase OS=Leuconostoc pseudomesenteroides PS12 GN=L965_696 PE=3 SV=1
----IKMVWAQDKKNAIGKNGSIPWH-MPDDLKLFRDETM-----N--TLMIMGRPTWLSIG---RPLPNRTSVVMTTDLNWTNYEVK-VVHSLDDAL--
-------NESRDISIAGGSVIYKAFMP-Y-ATDLVVTKIDGIIDGDTFVAPI---QFKLTSSE--A----H-D--YAYVVERYKRK-
>tr|B1MYC2|B1MYC2_LEUCK Dihydrofolate reductase OS=Leuconostoc citreum (strain KM20) GN=folA PE=3 SV=1
----IRMVWAEDSTHAIGKNGQLAWH-LPDDLKLFKAETM-----N--TLMVMGRTTWDTIG---RPLPGRTSLVLTHQKDFTPYDVI-IAHSVDEVL--
-------KETRDISIAGGAAIYHAFMP-Y-ATDLIVTRIDVTIAGDTFVDAI---QFKLVSAT--A----H-D--YSFVVERYERQ-
>tr|D8MFZ8|D8MFZ8_LEUGG Dihydrofolate reductase OS=Leuconostoc gelidum subsp. gasicomitatum (strain DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1
----IKMVWAEDRQHAIGKNGKLPWH-IPADLKLFREETT-----D--TLMIMGRTTWLSIG---QPLPNRTSLVLTRQLTWPDFDVL-VAHSADDVL--
-------NDSRDVSIVGGASIYRTFMP-Y-ATDLIVTRIDAVINGDTFVDEI---QFDLISQQ--A----H-E--YAFVVERYQRK-
>tr|K0D7F2|K0D7F2_LEUCJ Dihydrofolate reductase OS=Leuconostoc carnosum (strain JB16) GN=C270_04590 PE=3 SV=1
----IKMVWAEDQKHAIGKDGSTPWH-MPDDLKLFREETT-----N--TLMIMGRTTWLSIG---RPLPNRTSLVLTTQRDWTAFDVL-IAHSVEEVL--
-------AEKRDISIAGGASIYQAFMP-Y-ATELVVTRIDGIINGDTFVDPI---EFELVSKQ--L----H-D--YGFVVERYKRK-
>tr|A0A0N8VYJ6|A0A0N8VYJ6_LEULA Dihydrofolate reductase OS=Leuconostoc lactis GN=AN225_04800 PE=4 SV=1
----IKMVWAEDEQHAIGKNGDLPWH-LPDDLKLFKQETM-----G--TLMIMGRTTWDSIG---RPLPNRTTLVLTHQTDWPGYDVL-VAHSMSEVL--
-------AEDRDVTIAGGATMYQAFMP-Y-ATDLIITKVAGDVAGDTFAPAV---QFELIASQ--P----H-D--YAFVVERYQRK-
>tr|A0A087QCS6|A0A087QCS6_LACGS Dihydrofolate reductase OS=Lactobacillus gasseri SV-16A-US GN=HMPREF5175_00268 PE=3 SV=1
----IRFIWAEDEDGHIGYQGTLPWH-LPADLKHFKDLTS-----N--HIIVMGRRTFESFP---GLLPKRQHIILSTSPTLRKYHVK-IFSQLKELK--
-------HSEQTIDIIGGARVFEEFMD-E-VDMIEKTKIHHVFKGDTLMPKI---DFELINTK--A----H-K--FAYDFLEYERK-
>tr|G3YWW7|G3YWW7_9LACO Dihydrofolate reductase OS=Lactobacillus sp. 7_1_47FAA GN=HMPREF1027_00013 PE=4 SV=1
----IVFIWAEDLAGNIGNKGKLPWH-LPADLKHFKRLTE-----N--HTIVMGRKTFDSFP---GLLKNRHHVILTTDAEFNYYQIT-IFNSLTDLR--
-------EQ-KTIYIIGGFSLFDALKD-I-PDRLEQTIIQNKFKADTKMAII---RYKLINRK--D----F-K--YNYSFLTYVKL-
>tr|F4AGY4|F4AGY4_LACJH Dihydrofolate reductase OS=Lactobacillus johnsonii DPC 6026 GN=LJP_0759 PE=3 SV=1
----IRFIWAEDENGCIGYQGALPWH-LPADLKHFKELTS-----N--HIIVMGRKTFDSFP---GLLPKRKHIILSTNTILRKYRVK-VFSQIKQLK--
-------HTEETIDIIGGAEVFKEFKD-E-VDVLEKTKIHHIFKCDTWMPEL---DFKLVNSE--S----H-K--FDYDFLEYKRI-
>tr|A0A0R2D8P6|A0A0R2D8P6_9LACO Dihydrofolate reductase OS=Lactobacillus taiwanensis DSM 21401 GN=FD18_GL000428 PE=4 SV=1
----LRFIWAEDEASYIGYQGRLPWH-LPADMKHFKELTS-----D--HVIVMGRKTFESFP---GLLPKREHVILSTSPILREYRVK-IFSQIEQLR--
-------HSNEIIDIIGGARLFEEFEN-D-VDVLQKTKIHHLFVGDTKMSDI---DFKLFNIE--K----H-E--FDYDFLEYKRI-
>tr|A0A0A8AZ71|A0A0A8AZ71_LACGS Dihydrofolate reductase OS=Lactobacillus gasseri 130918 GN=P906_05715 PE=3 SV=1
----IRFIWAEDEDGHIGYQGTLPWH-LPADLRHFKDLTS-----N--HVIVMGRRTFESFP---GLLPKRQHIILSTSPTLRKYHVQ-IFSQLEELK--
-------HSNQTIDIIGGRRVFEEFMD-E-VDILEKTKIHHVFKGDTLMPEI---DFKSVNSE--I----H-K--FAYDFLEYKRI-
>tr|A0A0R1YG13|A0A0R1YG13_9LACO Dihydrofolate reductase OS=Lactobacillus hamsteri DSM 5661 = JCM 6256 GN=FC39_GL001212 PE=4 SV=1
----IKFVWAEDANHGIGYQGHLPWH-MPADMKHFKDETI-----G--HPILMGRKTFDSFP---HLLPKRKHLVLTRDKKLEKYQVE-IFSSIEIMN--
-------HQDEEISAIGGVSIFKALLD-K-VDQLEKTEINHEFEVDTYMPEI---QFELRKKE--A----H-K--YSYTFLTYVKK-
>tr|A0A0R2BNW3|A0A0R2BNW3_LACCL Dihydrofolate reductase OS=Lactobacillus collinoides DSM 20515 = JCM 1123 GN=FC82_GL000422 PE=4 SV=1
----MIFIWAEDLNHGIGFKGHLPWH-LSSDMKFFKRMTT-----G--NTLVSGSRTFLTYG---KPLPHRKNIVLTTNRQKYPEGVL-VLHSVDDLL--
-------HPEETIFISGGAKVFASLLP-Y-VDELVRTRIDHEFEVDTYMPTI---LFELVSSE--P----G-P--YPHFFDRFTRK-
>tr|A0A0R1LYS3|A0A0R1LYS3_9LACO Dihydrofolate reductase OS=Lactobacillus odoratitofui DSM 19909 = JCM 15043 GN=FD04_GL001083 PE=4 SV=1
----MIFIWAEDQNHGIGLKGTLPWH-LPADLKFFKQTTM-----G--NTLVSGRRTFASYK---KPLPHRKHVVLTTDSSAYPDDVT-VLHETQAVI--
-------HPDETVIISGGAKVFASLLP-Y-VDTLIRTRVDHAFEVDTYMPAI---KFKLVEQQ--H----R-Q--YALTFERWQRR-
>tr|A0A0R1T3D2|A0A0R1T3D2_9LACO Dihydrofolate reductase OS=Lactobacillus paracollinoides DSM 15502 = JCM 11969 GN=FC17_GL002880 PE=4 SV=1
----MIFIWAEDNNHGIGYKGNLPWH-LSSDMRFFKRTTT-----G--NTLVSGSRTFASYG---KPLPHRKNIVLTTNRHKYPEGVL-VLHSVDDLL--
-------HPDETIYISGGAKVFASLLP-Y-VDELLRTRIDHEFKVDTYMPDI---QFELVSSE--A----G-P--YVHYFEAFKRR-
>tr|A0A0R2EQK6|A0A0R2EQK6_9LACO Dihydrofolate reductase OS=Lactobacillus similis DSM 23365 = JCM 2765 GN=FD14_GL001902 PE=4 SV=1
----MIFVWAEDQQHGIGYQGTLPWH-LPADLAFFKKTTT-----G--HTLVSGSRTFASYK---KPLPNRKHVVLTNDCET--YGVV-VLHHVDEVL--
-------HPDETLMISGGAQVFASLLP-Y-VKTLIRTRVAHTFKVDTVMPTI---QFELVDSQ--V----R-P--YELTFERWERK-
>tr|A0A081BH90|A0A081BH90_9LACO Dihydrofolate reductase OS=Lactobacillus oryzae GN=LOSG293_060120 PE=3 SV=1
----FKFVWAEDQNHAIGFEGHLPWH-LPADMKFFKETTI-----D--HTLVSGSRTFASYG---RPLPRRKNIVLTLNPVEYPEGVI-ELHSLDELL--
-------HKDEEIYVSGGASIFKLLLP-Y-ASDLYVTKLDGQFPADTYMPEV---QFELVSSR--E----G-T--IPHRFEHYRRK-
>tr|A0A0R1I222|A0A0R1I222_9LACO Dihydrofolate reductase OS=Lactobacillus kimchicus JCM 15530 GN=FC96_GL000291 PE=4 SV=1
----MIFIWAEDQSHGIGYQGRLPW-HLPADMAFFKKTTT-----G--HTLLSGARTFQSYG--GRPLPHRKNLVLTSQNAD-QFDVV-VLPTVEAVLRQ
-------HPEETLYVSGGAQVFASLM-----QTLLKTRVDGRY-VDTYMPPI---AFKKVSSD--T-----EP--VALTFERYERQ-
>tr|D4YUF7|D4YUF7_9LACO Dihydrofolate reductase OS=Lactobacillus amylolyticus DSM 11664 GN=folA PE=3 SV=1
----ITFVWAEDEQHGIGYQGHLPWH-LPADMKHFKEKTL-----G--HPVLMGRKTFASLP---HLLPKRQHLVLTHNIDFKKYQVS-VFLNEQDLL--
-------HQADDIKAIGGVSIFKLLEK-Q-VDVLEKTVIHHRFEVDTYMPEI---DFKIIKKE--Q----H-K--FAYDFLTYKRK-
>tr|A0A0R1EQ65|A0A0R1EQ65_9LACO Dihydrofolate reductase subunit OS=Lactobacillus pobuzihii E100301 = KCTC 13174 GN=FD11_GL001904 PE=4 SV=1
----LAFIWAEDSDHGIGYQGQLPWH-MPADMKFFKDRTT-----G--NTIVAGRKTFESFK---HPLHNRKNIVLTSQDEKFPEGVV-VFHSIREVL--
-------QPSQNMFIIGGVQLFKDFLP-Y-VTDLYRTTIDHKFAVDTYMPEI---HFMLSDFV--E----G-P--YPYHFEHFMRV-
>tr|A0A0R1XIM1|A0A0R1XIM1_9LACO Dihydrofolate reductase subunit OS=Lactobacillus acidipiscis DSM 15836 GN=FC65_GL001814 PE=4 SV=1
----LAFIWAEDSNHGIGYQGQLPWH-MPADMKFFKDTTT-----G--NTIVAGRKTFESFK---RPLHNRKNIVLTSRDEKFPEGVV-VYHSVKEVL--
-------QPSQKMFIIGGVRLFEEFLP-Y-ATDLYRTTIDHEFAVDTYMPEI---HFMLSDFV--E----G-K--YPHHFEHFMRV-
>tr|I7KQF4|I7KQF4_9LACO Dihydrofolate reductase OS=Lactobacillus gigeriorum DSM 23908 = CRBIP 24.85 GN=BN52_01045 PE=3 SV=1
----LTYIWAEDLDRGIGYQGHLPWH-LPADLHHFKELTM-----G--RAMVMGKNTFLSLP---KVLPGRKHLVLTHDRNLKKYQVE-FFYDLTSLK--
-------NHDQEFAVIGGASIFKALEN-E-VDRLEMTKIKGVFAADTFMPKL---KFEIIHQE--Q----H-D--YDYTFFTYQRK-
>tr|A0A0A0IL42|A0A0A0IL42_CLONO Dihydrofolate reductase OS=Clostridium novyi A str. 4570 GN=Z969_06620 PE=3 SV=1
----LSIVVAVDENNVIGKDNSLPW-HLPNDLKYFKKVTLT---ES--KTMIMGRKTFESLK---TLLPGRKHIILTKNKN-VEDNVE-IINKIDTLK--
-------NDKKEYFVIGGGEIFSLLLP-Y-TEKIYMTKIHHNFSGDTFFPKIN-CDWNTAKKI--Q----G-I--YNHTFLILNRI-
>tr|A0PY39|A0PY39_CLONN Dihydrofolate reductase OS=Clostridium novyi (strain NT) GN=folA PE=3 SV=1
----LSIVVAIGKNNVIGKDHSLPW-HLPNDLKYFKKVTLT---ES--KTMIMGRKTFQSLK---ALLPGRKHIILTKNKN-MKDNVE-IINKIDMLK--
-------NDKKEYFVIGGGEIFSLLLP-Y-TEKIYMTKIHHNFIGDTFFPNIN-YDWNTTKEI--Q----G-V--YNHTFLILNRI-
>tr|A0A072XQB1|A0A072XQB1_CLOBO Dihydrofolate reductase OS=Clostridium botulinum C/D str. BKT12695 GN=Z962_01395 PE=3 SV=1
----LSIIVAVGENNVIGKENSLPW-YLPNDLKYFKKVTLR---ES--KTMIMGRKTFEALP---RLLPDRKHIILTKNKN-ITNNIK-IIHKINMLK--
-------NDKKEYFVIGGGEIFSMLLP-Y-TEKIYMTKIHHNFSGDTFFPSIN-CYWNTVEKI--Q----G-I--YSHTYLVLNRI-
>tr|M5J5S5|M5J5S5_9LACO Dihydrofolate reductase OS=Lactobacillus saerimneri 30a GN=D271_06110 PE=3 SV=1
----LAYIWAEDLDGHIGKDGHLPWH-LPADLSYFKQRTL-----G--HPILMGRKTFASF---PGMLPHRLHLVLTRNAALEKARVTDVFMTPTEMK--
-------HPDEDIFVIGGASLFTLLKD-E-VDTLYQTVIKAHFDGDVTMPAI---NFDLISVQ--S----G-Q--YPYEFRVYQRK-
>tr|A0A0A1GTV3|A0A0A1GTV3_9LACO Dihydrofolate reductase OS=Lactobacillus hokkaidonensis GN=IV59_GL001371 PE=3 SV=1
----ISFIWAEDLDGTIGKDGRLPWH-LPADMRRFKELTT-----N--HTVVMGKRTYESLN---RPLPRRRNIVLSNT--LPVENVE-IMRNADELE--
-------NTNDDVYIIGGAIVFATTIN-W-VDHLFRTVIADHFNGDTNMIPI---NWKLQERN--E----F-K--HDYVFESWSCQ-
>tr|A0A0R1TQV9|A0A0R1TQV9_9LACO Dihydrofolate reductase OS=Lactobacillus apodemi DSM 16634 = JCM 16172 GN=FC32_GL001111 PE=4 SV=1
----LAFIWAEDEVGHIGYEGKLPWH-LPADLAYFKAQTL-----G--HPMVMGKNTFNSFP---GFLPKRLHVVLTHDKQLQAARLM-VFDDLSQLK--
-------HDEL-VFIIGGASLFAQFKD-Q-VDQLFVTKIHSQFKGDTKMPEL---AFELVKKE--S----G-K--YPYTFYVYQKR-
>tr|A0A0R2AE79|A0A0R2AE79_9LACO Dihydrofolate reductase OS=Lactobacillus agilis DSM 20509 GN=FC14_GL001010 PE=4 SV=1
----LAYIWAEDRAGHIGNEGKLPWN-LPADLAYFKKQTM-----D--HPMLMGRKTFDSF---PGLLPHRLHLVLTRSAALKQAETTEVFNSVEEML--
-------HQAEEVFVIGGASLFELLKD-Q-VDVLYQTKIDAVFAGDVTFPEI---KFDLISVT--P----G-K--YPYEFRVYKRK-
>tr|A0A0C2U0M0|A0A0C2U0M0_BACIU Dihydrofolate reductase OS=Bacillus subtilis subsp. subtilis GN=B4067_4809 PE=3 SV=1
----LSLIACCDKSLAIGY-NKLLY-H-PADMKHFKEKTE-----G--KICIQGRSTYESIIS-GKPLQNRKNIILTRDQN-KPD--F-VYHSIEEVLQG
Q--V---NTDEEVMVIGGSMIYKAFLP-Y-ADKVYLTIVDSESNADSYFPML----WKATNKQ--H----N-K--NKYNYSFLTFE-
>tr|A0A0A0TW28|A0A0A0TW28_BACIU Dihydrofolate reductase OS=Bacillus subtilis GN=KS08_10270 PE=4 SV=1
----LSLIACCDKSMAIGYENNLLY-HIPEDMKRFKELTT-----G--KLCIQGRLTYESIVNTGKPLQNRSNIILTKNKD-PDHSSF-VYHSVNDVLRG
Q--L---DKDEEVMVIGGGAIYEAFLP-H-ADKVYLAIVDSVVAADSYFPRL----WRVIEKD--H----R-G--QDYSFITYENF-
>tr|A0A0R2G9V3|A0A0R2G9V3_9LACO Dihydrofolate reductase OS=Lactobacillus acetotolerans DSM 20749 = JCM 3825 GN=FC77_GL001429 PE=4 SV=1
----ITYVWAEDQKHQIGINGHLPWH-LPADMKHYKKETM-----G--HPMIMGRRTFASFP---KVLPGRKHIVLSRNEDLKKYQVL-VLPSLDKLN--
-------HKDEKVCAVGGASIFKALLN-R-VDCLEKTQIDATFKADTVMPAI---QFTLIKNE--H----H-K--YPYSFLTYIRK-
>tr|D6S5N0|D6S5N0_9LACO Dihydrofolate reductase OS=Lactobacillus jensenii JV-V16 GN=folA PE=3 SV=1
----LSFVWAEDNKHQIGYKGHLPWH-LPADLAHFKEKTM-----G--KTMVMGKKTFLSLP---FVLPKRKHLVLTHDEALQKYQVN-FVTSMEQLR--
-------HKEDEVAVIGGVSVFEGLKD-I-VDCLEKTEIDGEFKADTIMPKI---AFKLIKKE--S----F-P--YDYSFLTYLRK-
>tr|A0A0R1NP38|A0A0R1NP38_9LACO Dihydrofolate reductase OS=Lactobacillus gallinarum DSM 10532 = JCM 2011 GN=FC37_GL000475 PE=4 SV=1
----IEYVWAEDEKRQIGVEGHLPWH-LPADLKHFKEKTM-----D--HPILMGRKTFASLP---KLLPGRKHIVLTHNEELSKWQVE-ILTSIDEMN--
-------HQSEKICAIGGVSIFKALLD-Q-VDILEKTEIEGVFKADTVMPEI---QFDLVHQE--H----H-K--YPYTFLTYIRK-
>tr|F6CE80|F6CE80_LACKZ Dihydrofolate reductase OS=Lactobacillus kefiranofaciens (strain ZW3) GN=WANG_0764 PE=3 SV=1
----IEYVWAEDEKHQIGLNGHLPWH-LPADLRHFKEKTI-----G--HPIIMGRKTFMSLP---KLLPQRKHIVLTSSQELQKYQVL-ILSSLAEIN--
-------HKQEKMCVIGGASVFKALID-Q-VDILEKTAIEAVFEADTKMPAI---QFALLNKE--H----H-K--YPYTFLTYQRK-
>tr|A0A0R1XP33|A0A0R1XP33_9LACO Dihydrofolate reductase OS=Lactobacillus intestinalis DSM 6629 GN=FC44_GL000024 PE=4 SV=1
----IEFVWAEDNKHAIGYKNHLPWH-LPADLKHFKNLTM-----G--HPMIMGRKTFTSLP---KVLPGRQHLVLTHDQQLEQYRVT-FFTSIDDLK--
-------NPETCFCAIGGVSIFELLAD-K-VDILEKTLIYEKFKADTFMPEI---KFELINKE--D----H-H--YPYTYFTYKRK-
>tr|G0QDT6|G0QDT6_NANSJ Dihydrofolate reductase OS=Nanosalinarum sp. (strain J07AB56) GN=J07AB56_11630 PE=3 SV=1
----KVVVVATDEDNVIGEKGEIPW-H-PEDLRHFRDLTI-----G--HPVIMGRSTYESLPD-HRPLPERTNVVLTRSGLDELGHDS-VQ--EANSLFS
I--S---ELSDTVFIGGGETVYEQTLED--ADRIELTRIHDTH-GDTFFPE----EWVEASR----------G--EQLSFVTLRRR-
>tr|A0A059WY28|A0A059WY28_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----INMVVAAAQNGTIGINNDLPW-H-SSDLKHFKQLTT-----G--KPVIMGTNTYNSIYNLKGPLPNRRNIVVSRQSTSLPAELA-H--SINEAL--
-------LGGSDASLIGGAQLFKSFLDQDLIDRIYLTEVKADV-GDVYLPPL---DWQEVDRQ--P------Q--WQYDFVTLERK-
>tr|A0A0R1WM34|A0A0R1WM34_9LACO Dihydrofolate reductase OS=Lactobacillus hayakitensis DSM 18933 = JCM 14209 GN=FC40_GL000759 PE=4 SV=1
----ISFVWAEDLQGNIGYKGKLPWR-LPNDLKFFKEVTS-----Y--KPIVMGRKTFESFP---NLLPNRLHVVLTRNQQLTLYQVI-VYNSVEDIK--
-------LQVPEVCIIGGAEIFDIFVD-S-VTKLYRTQVNHVFNGDTKMIPI---MFNLVLQI--N----G-I--YPHTFQIFKKK-
>tr|A0A059XB47|A0A059XB47_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----VCVIVAMDQARVIGFKNRLPW-H-PEDMKRFAKLTT-----G--HTVLMGRKTYESLPD-FRPLPKRKNMVITRSPAQAAEVVL-VFSSPGAAIHH
H-SE---VSGGQLWIIGGGEIYRENMEY--VDQIYLTVVDGTH-GDVYFPE----DFVLAEW----------H--EGFEYRLYRRK-
>tr|A0A059XDJ8|A0A059XDJ8_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ICAIVAMDEARVIGLNGKLPW-H-PEDMKRFSKLTT-----G--HTVLMGRKTYESLPP-FRPLPARKNIIVSRS---APEGVE-VWNSPVECLRA
H-PE---LPSDRLWVIGGAQIYQETEQF--WDEIDLTFVKGKH-GDTFFDS----DFSLVTE----------F--SAGSFRIYKRN-
>tr|A0A0L0WCT4|A0A0L0WCT4_CLOPU Dihydrofolate reductase DfrA OS=Clostridium purinilyticum GN=dfrA PE=4 SV=1
----ISMIVAVDRSWGIGR-NDMLA-H-EPDLEYFRNVTE-----G--HTVIMGYNTYLSL-PENRPLPNRKNIVITRK-N-KLEGVT-IIDSIEETLNK
---E---YKNEEVFIAGGESIYNQMLP-Y-ADKLYITHIFRKFDPQAFFPII----WRIEDIK--M----S-E--CPHIFATYVKK-
>sp|Q59397|DYR9_ECOLX Dihydrofolate reductase type 9 OS=Escherichia coli GN=dhfrIX PE=3 SV=1
----LNMIVAVNKTGGIGFENQIPW-H-PEDLKHFKAVTM-----N--SVLIMGRKTFASLP---KVLPGRLHVVVSKTVP-QNTDQV-VYVSSLLVD--
-------PEYSQIFVIGGKSAYENLAA-Y-VDKLYLTRVQLNT-QDTELDLSLF--WKLVSEV--P------K--TKLIFQIWINP-
>tr|A0A0K2FMH0|A0A0K2FMH0_9CAUD Putative dihydrofolate reductase OS=Brevibacillus phage Sundance GN=SUNDANCE_96 PE=4 SV=1
----MIAITAMDSNNAIGKDDKLLC-KLKDDLEYFRLVTE-----G--HIVVMGSKTFESIGG---LLPNRINIILTRNKN-IPK----SSDDVLDFL--
--------NDKKMFIIGGGQIYEEFL--SYCDSLIVSHIHASFKANVYFPKVNW--WEPVGYP--I----G-E--YTFSTVIYEKT-
>tr|Q5FKL5|Q5FKL5_LACAC Dihydrofolate reductase OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) GN=dfrA PE=3 SV=1
----IEYVWAEDKEKNIGLNGHLPWY-LPADMKHFKEVTI-----N--HPIIMGRKTFESFP---NLLPKRKHIVLTHNEELNKYQVT-ILPTVEDLH--
-------HQDERMCAIGGVSIFNALMD-Q-VEVLEKTEIDAIFEADTKMPEI---RFNLVAKK--H----Y-K--YPYTFLTYKLK-
>tr|A0A0R1PT83|A0A0R1PT83_LACHE Dihydrofolate reductase OS=Lactobacillus helveticus DSM 20075 = CGMCC 1.1877 GN=FC11_GL001314 PE=4 SV=1
----IEFVWAEDQKHQIGLDGHLPWR-LPADMAHFKEKTI-----G--HPIIMGRKTFMSLP---RLLPQRKHIVLTHDQDLKKYQVT-IINSIAELG--
-------HQGEKLCVVGGVSIFKALLD-Q-VDVLEKTEIDATFEADTVMPEI---QFKLVKKE--H----H-K--YPYTFFTYQRK-
>tr|M5ADI3|M5ADI3_LACBR Dihydrofolate reductase OS=Lactobacillus brevis KB290 GN=LVISKB_1194 PE=3 SV=1
----LIFLWAESQGRVIGLQGGLPW-HLPADMHYFKTVTT-----G--HTIVAGSKTFASFP---RPLPNRKNIVVSHQPA-TAFNVS-VLHSLPAVRAA
-------RPQEKIFVVGGAQLFAGLLD-D-VDFLYRTRIDAGFDGDTWMPVI---QFTLIDQQ--P----G-P--YDFVFEQYQRH-
>tr|A0A0R2DP69|A0A0R2DP69_9LACO Dihydrofolate reductase OS=Lactobacillus senmaizukei DSM 21775 = NBRC 103853 GN=FD13_GL001773 PE=4 SV=1
----LIFLWAEGHDGVIGQNGQLPW-HLPADMHFFKTATT-----G--HTVIAGAKTFASFK---RPLPNRTNVVVTHQAA-EKFEVV-ILHSIEAIRRE
-------RPTEKLFVVGGAQIFAALLD-D-VDWLYRTVIDADFRGDTWMPAI---QFNLVKCQ--T----G-P--YDYRFEQYQRN-
>tr|A0A0R1H555|A0A0R1H555_9LACO Dihydrofolate reductase OS=Lactobacillus parabrevis ATCC 53295 GN=FD07_GL001976 PE=4 SV=1
----LIFLWAEGHNGVIGQNGQLPW-HLPADMHFFKTVTT-----G--NTIVAGARTYRSFG---RSLPNRQNIVVTHQPA-SNFTVI-VLDSLDAVRAA
-------HSDDKIFVVGGAQLFVGLQD-D-VDFLYRTVIDANFTGDTWMPVM---KFQLIATQ--P----G-P--YDYHFEQYQRR-
>tr|A0A0R1UWY9|A0A0R1UWY9_9LACO Dihydrofolate reductase OS=Lactobacillus hammesii DSM 16381 GN=FD28_GL002120 PE=4 SV=1
----LIFLWAEGHNGVIGENGHLPW-HLPADMHFFKTVTT-----G--NTIVAGSRTFHSFG---RPLPNRQNIVVTHQPA-SHFEVI-VLNTLTAVRAK
-------HRDEKIFVVGGAQLFIALLD-D-VDFLYRTVIDANFTGDTWMPGI---KFQLIATQ--P----G-P--YDYHFEQYQRR-
>tr|A0A0R1FS59|A0A0R1FS59_9LACO Dihydrofolate reductase region OS=Lactobacillus kunkeei DSM 12361 = ATCC 700308 GN=FD43_GL000566 PE=4 SV=1
----ISFLWAESDNHIIGLNGGLPWH-LPADMKYFKETTT-----H--QIIMAGRTTYESF---KRPLPNRLNTVLTSHDKSYPNDVV-VFNTLEEFL--
-------FSDKEIFVVGGAKIFAELLP-Y-VDRLYRTVIDYDFEGDTQMPEI---QFDLVSTK--E----G-I--YPYRFEIFERK-
>tr|A0A0R1LP81|A0A0R1LP81_9LACO Dihydrofolate reductase OS=Lactobacillus acidifarinae DSM 19394 GN=FD25_GL000595 PE=4 SV=1
----LIYLWAESYGGVIGYHGHLPW-HLPADMHYFKTTTT-----G--QTVIAGAKTFASFG---RPLPHRTNVVVSHRPA-SDFNVT-VLGSLAAVRAA
-------HPQDLLYVVGGAQLFAGLLP-D-VDRLYRTTIDADFPGDTRMPAI---QFVKIGEQ--V----G-P--YDYVFEQFERR-
>tr|A0A0R1K9Z8|A0A0R1K9Z8_9LACO Dihydrofolate reductase OS=Lactobacillus namurensis DSM 19117 GN=FD30_GL000040 PE=4 SV=1
----LIYLWAESHGGVIGYQGQLPW-HLPADMHFFKTTTT-----G--HTIIAGARTFASFG---RPLPHRKNIVVSHRPA-ADFDVT-VLGSLTAVRRA
-------HEAEQLFVVGGAQLFAGLLP-D-VDQLYRTTIQADFPGDTWMPEI---QFTRIGHQ--I----G-P--YPFTFEQFQRK-
>tr|A0A0R1KQT7|A0A0R1KQT7_9LACO Dihydrofolate reductase OS=Lactobacillus koreensis JCM 16448 GN=FC99_GL002312 PE=4 SV=1
----LIFLWAESQGHVIGFKGQLPW-HLPADMHFFKTVTT-----G--NTIIAGSKTFASFP---HALPNRKNVVLTHQSA-ANFSVT-VLDSFDAVRAQ
-------RPTEKLFVVGGAQLFNGLQA-D-VDFLYRTTIDAGFDGDTWMPAL---KFQRINRQ--P----G-P--YDYVFEQFQRI-
>tr|A0A0R2LQC9|A0A0R2LQC9_9LACO Dihydrofolate reductase OS=Lactobacillus paucivorans GN=IV54_GL000369 PE=4 SV=1
----LIFLWAEGNQGVIGQNGRLPW-HLPADMHFFKTVTT-----G--NTILAGSRTYASFG---RPLPNRQNIVITHQDR-TNFEVI-VLDSIDAVRAT
-------HRQDKLFVVGGAQIFEALLP-D-VDQLYRTVIDADFAGDTWMPAI---QFKLTATQ--P----G-P--YDYRFEQYQRL-
>tr|A0A0R1R0Q4|A0A0R1R0Q4_9LACO Dihydrofolate reductase OS=Lactobacillus spicheri DSM 15429 GN=FD37_GL002259 PE=4 SV=1
----LIFLWAESEGGVIGYHGHLPW-HLPADMHFFKTQTT-----G--HTVIAGAKTFASFK---RPLPNRQNVVVSHRPA-SAFGVT-VLNSLTAVRAE
-------HAAEKLFVVGGATLFSGLAA-D-VDQLYRTQIHATFPGDTVMPAI---QFERIGHQ--P----G-P--YDYEFDQFQRK-
>tr|L1MWR4|L1MWR4_9FIRM Dihydrofolate reductase OS=Peptostreptococcus anaerobius VPI 4330 = DSM 2949 GN=HMPREF9998_00001 PE=4 SV=1
----YMIVAMTEKTNAIGINGDMLF-YLKDDLKYFKETTL-----N--HTIVCGRKTYFSFP--RRPLPNRKNIILTRGDG---EGAY-TLHSKEELVIN
-------NPKEDIFICGGDNVYKQFMD-V-ASKLYVTIIDEDAVADSFFPKFCD--WQLVFES--T----Y-A--PRYKFTVYDRK-
>tr|D6GQY5|D6GQY5_FILAD Dihydrofolate reductase OS=Filifactor alocis (strain ATCC 35896 / D40 B5) GN=folA PE=3 SV=2
----YMIVAMTEKTRAIGKNNDMLY-HLPEDLKYFKQTTQ-----G--HTIVIGYNTYMSFP--KRPLPNRKNIVLTRKNR---EGVE-ILHSIEEVLKV
-------HSEEQIFICGGDTIYEQFMP-Y-VSKLYLTVIEEEPVAEAFFPEVDT--WKKTEEN--P----S-T--PNYTFTVWEKR-
>tr|A0A096A0M2|A0A096A0M2_9FIRM Dihydrofolate reductase OS=Peptostreptococcus sp. MV1 GN=HMPREF1639_02630 PE=3 SV=1
----YMIVAMTKNTRAIGIDGGMLY-HLKEDLKYFKETTL-----N--HTIVCGRKTYFSFP--KRPLPNRKNIILTRGSD---ENAY-SLHSKDEVILD
-------NPNEDIFICGGDNVYKQFMD-I-ASRLYITEIDEDPVADSFFPEIDR--WTEVSRS--D----Y-A--PRYRFLVYNRL-
>tr|E0E1Z6|E0E1Z6_9FIRM Dihydrofolate reductase OS=Peptostreptococcus stomatis DSM 17678 GN=folA PE=3 SV=1
----YMIVAMTKNTRAIGIDGDMLY-HLKDDLRYFKETTL-----N--HTIVCGRKTYFSFP--KRPLPNRKNIILTRGNN---DQAY-TLHSKEDVVLD
-------HPDEKIFICGGDNVYKQFMD-I-ASRLYITEIEEDPVADSFFPYVDP--WSKASES--D----Y-T--PCYKFIVYDRK-
>tr|H3NNZ2|H3NNZ2_9FIRM Dihydrofolate reductase OS=Helcococcus kunzii ATCC 51366 GN=HMPREF9709_01053 PE=3 SV=1
----YMIAAITENTHAIGKNGDMIY-HLKNDLRYFKETTL-----G--HTIVCGKKTYFSFP--KRPLPNRKNIILTRSND---DGAY-TLHSKEEVINN
-------NPEETIFIVGGDSVYHQFID-V-ASKLYITEVEEITAADSFFPTFDK--WELESLS--D----F-E--PKYRYEIYRRK-
>tr|D3B2M2|D3B2M2_POLPA Uncharacterized protein OS=Polysphondylium pallidum GN=PPL_02636 PE=3 SV=1
----ISFVVAVSLNNVIGK-GGIPW-R-KGDLAFFSKTTT-----G--HPIVMGRKTFDSI-G--RPLPNRHSIVITSSGK-YNR-IE-YQEKTDQAI-N
---N---LNSDVVYIIGGETIYKETFK-Y-ANELLITTVDTVIEGDTFFNLFPN-SWVIMDKK--S----F-E--YDYTISTLKRE-
>tr|S5M436|S5M436_9CAUD Dihydrofolate reductase OS=Bacillus phage Basilisk GN=BASILISK_62 PE=4 SV=1
----IKMILACDLNGVIGNNRELPW-GLPYDLNRFKELTE-----G--HIVVMGRKTFESLG-S-KPLPNRENVVLSRSIL-EHLKTK-LYHSDEYDW--
-------GGDRDLWIIGGLNVYEQFMP-Y-VQEIYLTVVKGRF-GDTKIDRGLF-NNFNREVI--E----Y-E--NKYGMTFV-KY-
>tr|A0A0R1VR71|A0A0R1VR71_9LACO Dihydrofolate reductase OS=Lactobacillus ghanensis DSM 18630 GN=FC89_GL001585 PE=4 SV=1
----LAYIWAEDLNHQIGYRGQLPWH-LPADLAHFKRMTQ-----G--HPMIMGRKTFASLP---GVLPGRPHYVLTRSANYQSYRVK-IFHTKQELE--
-------DQRL-NFIIGGASLFASFAN-Q-VDLLYVTKIAATFAGDVKMPQL---EFDLVWAK--R----G-L--YPYQFKLYCRK-
>tr|A0A0R2CBL9|A0A0R2CBL9_9LACO Dihydrofolate reductase OS=Lactobacillus vini DSM 20605 GN=FD21_GL000851 PE=4 SV=1
----LAFIWAEDIQHHIGYRGKLPWH-LPADLAHFKRMTL-----H--HPIIMGRRTFESFP---GLLPQRHHYLLTHDQKHQQYQMT-VVHSKQALG--
-------DSQL-FFIIGGASLFAAFAE-Q-VDLLYVTKIAANFSGDVKMPPI---KFELVWAK--R----G-H--YPYQFKLYRRQ-
>tr|I7JYL6|I7JYL6_9LACO Dihydrofolate reductase OS=Lactobacillus pasteurii DSM 23907 = CRBIP 24.76 GN=BN53_06110 PE=3 SV=1
----LTYVWTEGKNHEIGYQGHLPWH-LPADLKHFKELTM-----G--HEMLMGKGTFDSLP---GLLPGRRHLVLTHEKKQSQFQVE-FF-DLPQLS--
-------HQAESIMVIGGVSLFKLLCD-Q-VDCLEMTKIDGEFAADTYMPDL---KFELIKSK--S----F-S--YNYKFLTFSKK-
>tr|A0A0R1QGR2|A0A0R1QGR2_9LACO Dihydrofolate reductase OS=Lactobacillus nagelii DSM 13675 GN=FD45_GL001564 PE=4 SV=1
----LAYIWAEDLHHQIGFQGHLPWY-LPADLAHFKRVTQ-----G--YPMIMGRKTFASLP---GILPGRPHCVLTSSSEYQKYRVK-IFHTTKQLV--
-------DNQL-KFIIGGASLFAAFAD-Q-VDLLYVTKIAAAFKGDVKMPSL---EFDLIWAK--K----G-K--YPHQFKLYSRR-
>tr|A0A0M4T7I0|A0A0M4T7I0_9GAMM Dihydrofolate reductase OS=Psychrobacter urativorans GN=AOC03_05610 PE=3 SV=1
----VAQIAAISRNRCIGKGNDLPW-HIPTDLQHFKQLTT-----QNKGIVIMGRKTFESMG--SKPLPKRISFIITSQLD-QQQNAH-VLHDLASALAD
L--A---LQLKTIWVIGGERVFSEALS-V-TDRIELTHVDTDIEGDAFYPELP--EFKVVAES--E----Q-E--LDFKFVTYQK--
>tr|A0A0Q9ZVH1|A0A0Q9ZVH1_9GAMM Dihydrofolate reductase OS=Psychrobacter sp. P11F6 GN=AK822_13210 PE=4 SV=1
----VAQIAAISSNRCIGKDNELPW-HISADLQHFKSMTT-----KEQGIVIMGRKTFESMG--SKPLPKRVSFIISTQLD-EQKNAY-VVHNLDDALAS
L--A---AHLDTIWVIGGERVFSDALM-Y-TDRIELTHVDTEITGDAFYPELP--EFEVAEES--E----K-D--LDFKFVTYKIK-
>tr|U4T7L9|U4T7L9_9GAMM Dihydrofolate reductase OS=Psychrobacter aquaticus CMS 56 GN=M917_0117 PE=3 SV=1
----EVAIAAISGNRCIGK-NELPW-H-SADLQHFKQMTTKENAVQ--GIVIMGRKTFESMDSK--PLPKRVSFIVTQLDY---ENAY-VVHNLDDALAS
LAHG---AHLDTIWVIGGERVFSDAMM-Y-TDRIELTHVDTDITDAF-YPELPD-FI-------AE----S-A--LDFKFVTYQRK-
>tr|A5WHY1|A5WHY1_PSYWF Dihydrofolate reductase OS=Psychrobacter sp. (strain PRwf-1) GN=PsycPRwf_2332 PE=3 SV=1
----VAQIVAISRNRCIGKGNDLPW-HIPNDLKHFKAMTT-----AEKGIVIMGRKTFESMG--SKPLPKRVNFIVTTQMD-QQKDVH-VVHNLDDALAN
V--A---LKFETIWVIGGERVFKRAMM-F-TDRIELTVVDTDIEGDAFYPEIP--DFELTQES--E----S-G--LSYKFMTYMVK-
>tr|X0QR93|X0QR93_9GAMM Dihydrofolate reductase OS=Psychrobacter sp. JCM 18900 GN=JCM18900_11959 PE=3 SV=1
----VAQIAAISSNRCIGKNNELPW-HISADLQHFKSMTT-----KEQGIVIMGRKTFESMG--SKPLPKRVSFIVTTQMD-ETKNAY-VVHNLDDALAS
L--A---AHLDTIWVIGGERVFNDALM-Y-TDRIELTHVDTDIAGDAFYPELP--RFKVADES--E----Q-D--LSFKFTTYKVE-
>tr|A0A060Q1C9|A0A060Q1C9_9RICK Dihydrofolate reductase OS=Wolbachia endosymbiont of Cimex lectularius GN=folA PE=3 SV=1
----IIGVMAVDPNGVIGINNGLPWH-YPSELEHFRQVTD-----K--QVIVMGRKTFETMPQ---ILKDRVPVVFSRNKLSL-CKCT-VVSS----MLS
--------NYSKIFMVGGAQIAHLFLEHNLISEFIITEIHKPYKGEVYFNLA---GWNKTILT--E----T-------TICRLIYA-
>tr|A0A0G1CSX6|A0A0G1CSX6_9BACT Dihydrofolate reductase OS=Parcubacteria bacterium GW2011_GWC1_43_11b GN=UV64_C0017G0005 PE=4 SV=1
----ISMVVATDRSGIIGCDGQLPW-D-PIDRRRFKNLTM-----G--HPVIMGRKTFESIDP-FRPLPGRTNIVLSQTMTD-VEKVV-VARDISQALES
-------PGNEEIFVIGGHSVYRDFLPF--TNRIYWTLVGMDCHTYVRFPTS---GWKMGKFE--M----P-R--PAIAFFTFDR--
>tr|A0A0H4JTC6|A0A0H4JTC6_VIBCL Uncharacterized protein OS=Vibrio cholerae GN=EN12_20870 PE=4 SV=1
----ITLIACVSKNLAIGKGNDLLFS-FSEDMEFFKTNTM-----C--KPVIMGARTAHSLP-NSAPLKNRHNFVLCSEKDEF-FGFV-TVASIPDAIRD
---N------KELLVIGGGMIYKESISI--ADRLLVTVVDEVVDADTFFPIIDA-KWVLNWLTSGK----N--E--KLTFSEYLKK-
>tr|A0A0L7YXJ1|A0A0L7YXJ1_VIBPH Uncharacterized protein OS=Vibrio parahaemolyticus GN=ACS91_20845 PE=4 SV=1
----ITLIACVSKNLAIGKGNDLLFS-FREDMEFFKTNTL-----H--KPVIMGARTARSLP-NSAPLKNRDNFVLCSEKDKF-FGFA-TVNSIPEAISD
---N------QELLVIGGGMIYKESISI--ADRLLITVVDEVVEADTFFPIIDS-KWVLNWSTSGK----T--E--KLTFSEYLKK-
>tr|A0A059WQP7|A0A059WQP7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ISIIAVLGDTRAIGIDGDLIW-T-RADKIRFRKLTY-----G--HPVIMGRKTWDSLPD-YRPLPGRTNIIISRDAS-IPGA-I-VVRSLDDAIRK
-------LGSDEIFIIGGGIVYAKALPY--VDRLYLTLVQSDAAGDVFFPEY---FPEEIERI---------D--PTLTFLTLER--
>tr|A0A059WQD1|A0A059WQD1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IIIIVAYDLNRLIGADNTLIW-H-PEDLKRFKVLTM-----G--GICIMGRNTWESLPE-VRPLPGRKNIVITHNPD-VPN-VV-LASSWEDAKQD
P-EQ---YHGKNIYVCGGAQIYTLSLP-D-ADQVQVTEVAKIFSNPKYFPEL---MVPTLLKS--N----Q-G--LFYDYIQYDKL-
>tr|A0A094J0E9|A0A094J0E9_9MOLU Dihydrofolate reductase OS=Mollicutes bacterium HR2 GN=dfrA PE=4 SV=1
----IILIAAVDLNNGLGYQGELLAN-IPEDMKHFKKLTM-----D--HSIVMGDTTWYSLPMGSHRLSGRHNVILTRSNRKVEG--T-DFDTITDDITM
---S------EDVYIIGGASVYKQFYQY--ADVIELTIFNTTFEADIFFPIIDN-DFILQNQYVQE----R-KDDFSLSFLTLVRR-
>tr|D4G8G5|D4G8G5_RIEPU Dihydrofolate reductase OS=Riesia pediculicola (strain USDA) GN=folA PE=3 SV=1
----ISLIAISKFNFVIGYENDIPW-KLPDDLSWFKKKTI-----K--KPIIVGRTTHECIG--T--LPDRLNIIMTNKR--KIFEKI-WVTSR-EEAIS
-------EDIKEIMVIGGEKIYKLFFP-I-ADRLYITYVDY-FGGDVFFPFISK--WRCSYIG--D----A-S--HSYIHKIFDRK-
>tr|A0A0C1S0J1|A0A0C1S0J1_9ENTR Dihydrofolate reductase OS=Candidatus Riesia pediculischaeffi PTSU GN=P689_11943 PE=3 SV=1
----ISLISVSRFNSAIGYKTLIPW-KLSNDIKWFKRITV-----N--KPVIVGRTTHEIIG--K--LPMRMNIVLSRDQK-ESKDRI-WVSSV-EQAVP
-------DKTKEIMIIGGEKIYRLFFP-I-ANRLYITYVDY-QGGDTFFPSISK--WICSYVS--R----T-S--HRHVHKIFKKR-
>tr|I3UMB2|I3UMB2_9CAUD Dihydrofolate reductase type I OS=Colwellia phage 9A GN=COPG_00031 PE=4 SV=1
----LNMILATDNEHGIGKDNDLAWF-CSADLTLFKQKTL-----N--THIIMGHNTAKSLPK---PLARRINVVLCSKVPENPVGFY-YFT----TVLD
--------QGNDSWVIGGAEIYKLFAEH--CDEIHETDIEGTHDCDIFFNPSDH-AYRMEHPE--S----F-SVT--IWS----NK-
>tr|I7LRI1|I7LRI1_9LACT Dihydrofolate reductase OS=Lactococcus raffinolactis 4877 GN=BN193_01145 PE=3 SV=1
----IAGIWAEDAQGLIGSNGILPW-FLPSELQHFKQTTM-----G--KVILMGRKTFEGMH--KRVLPGRTTIVMTRDETYV-AAVL-VFHSPEAVLHG
Q--E---ESAKDLYITGGAEMFIAFKDS--FEQLYRTIIAGEFEGDTYFPKL---NFKEVSSV--T----H-D--YAFTVKRYEIK-
>tr|A0A0D6DXF6|A0A0D6DXF6_9LACT Dihydrofolate reductase OS=Lactococcus piscium MKFS47 GN=LACPI_1264 PE=3 SV=1
----IAGIWAEDAQGLIGVNGTLPW-SLPAELRHFKATTM-----G--QAILMGRKTFDGMK--QRTLPGRTTIVMTRDKSYV-ASVL-IFHQPQAVLAA
Q--S---DSAKDLYIIGGAEMFQVFSQS--LDHLYRTIVSGVFEGDTYFPDI---HFSELSST--I----H-K--YGFTVKTYEKN-
>tr|Q8DZ08|Q8DZ08_STRA5 Dihydrofolate reductase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN=folA PE=3 SV=1
----IIAIWAEDEDHLIGVNGGLPW-RLPKELHHFKETTM-----G--QALLMGRKTFDGMN--RRVLPGRETIILTKDEQFA-D-VT-VLNSVEQVIQE
H--N------KTLFIVGGASIYKAFLPY--CEAIIKTKVHGKFKGDTYFPDV---EFKVISRD--Y----F-A--HAFTVTYFEK--
>tr|A0A091C9C8|A0A091C9C8_STREI Dihydrofolate reductase OS=Streptococcus equinus ATCC 33317 GN=B279_06245 PE=3 SV=1
----IVAIWAEDENHLIGVNDGLPW-RLPKELKHFKETTM-----G--QALLMGRVTFDGMK--RRILPGRETLILTRDKAFA-D-VT-VVNDMDQVFKN
H--D------KTLYVVGGASIYKAFLPY--CDEIIKTTVHGEFDGDTYFPDA---QFTKVSES--F----Y-A--YDFTITVFKK--
>tr|A0A081JH32|A0A081JH32_STRMC Dihydrofolate reductase OS=Streptococcus macedonicus GN=FD61_06045 PE=3 SV=1
----IVAIWAEDENRLIGVDDGLPW-RLPKELKHFKETTM-----G--QALLMGRVTFDGMN--RRILPGRETLILTRDKSFA-D-VT-IVHDMDEVFEK
Q--D------KTLYIVGGASIYKAFLPH--CDAIIKTTVHGVFEGDTYFPDV---SFRKVSET--F----N-T--YDFTITVLEK--
>tr|H6P906|H6P906_STRIC Dihydrofolate reductase OS=Streptococcus infantarius (strain CJ18) GN=dfrA PE=3 SV=1
----IVAIWAEDENRLIGLDDRLPW-RLPKELKHFKETTM-----G--QALLMGRVTFDGMK--RRILPGRETLILTHDKSFA-D-VT-VVHDVEQVLKT
H--D------KTLYIVGGASIYETFLPY--CDAIVKTTVHGEFEGDTYFPNI---AFKKVSES--F----N-A--YDFTITVFEK--
>tr|Q9A091|Q9A091_STRP1 Putative dihydrofolate reductase OS=Streptococcus pyogenes serotype M1 GN=dyr PE=3 SV=1
----IIAIWAEDEAGLIGIAGKLPW-YLPKELEHFKKTTL-----H--QAILMGRVTFEGMN--CKRLPQRQTLVMTRNRDYV-D-VL-TMTSIEKVLHA
Q--D------KTLYIIGGNKVLEAFNGY--FDRIIKTVIHHRFKGDTYRPNL---HFTQESQT--F----Y-P--YDFTVTALKHK-
>tr|F5U4W2|F5U4W2_STREQ Dihydrofolate reductase OS=Streptococcus dysgalactiae subsp. equisimilis SK1249 GN=folA PE=3 SV=1
----MIAIWAEDEAGLIGVDGKLPW-YLPRELQHFKETTL-----N--QAILMGRVTFDGMN--RRLLPNRQTLVMTRDVNYV-D-VL-TMTSVEEVLHA
Q--E------KTLYVIGGSKVLEAFDGY--FNRVIKTVVHHQFEGDTYRPKL---RFREESQT--F----Y-P--YDFTVTVLKHQ-
>tr|F3L7B3|F3L7B3_STRPO Dihydrofolate reductase OS=Streptococcus porcinus str. Jelinkova 176 GN=folA PE=3 SV=1
----IIAIWAEDENGIIGSNGTLPW-HLPRELQHFKNTTL-----H--HAVLMGRVTFEGMK--AKLLPNRQTLVMTSNERYV-E-VL-TVTSLEEALHA
Q--E------KNLYVIGGAKVLKSFEGY--FNRIIKTVVHHQFEGDTYRPDI---DYIEEDQF--F----Y-P--FDFTVHVLVKK-
>tr|A0A0P6SF39|A0A0P6SF39_9STRE Dihydrofolate reductase OS=Streptococcus phocae GN=AKK44_02020 PE=4 SV=1
----IVAIWAEDESGVIGVDGRLPW-HLPKELQHFKQTTL-----N--QAILMGRVTFDGMK--RRLLPNRQTLVLTRDKHYV-D-AL-TMASVEQVLHT
Q--E------KTLYIIGGNKVLEAFDGY--FNKIIKTVVHHRFDGDTYRPRL---RFVTAEEV--F----Y-P--YDFTVTVLKHH-
>tr|G5K3J2|G5K3J2_9STRE Dihydrofolate reductase OS=Streptococcus ictaluri 707-05 GN=folA PE=3 SV=1
----IIAIWAEDQSGLIGVDGKLPW-YLPKELQHFKETTL-----N--QAILMGRVTFEGMQ--RRLLPNRQTLVMTRDETYV-P-VV-TVTSLEQVLHA
Q--E------KSLYVIGGSQVLESFDGH--FDRIIKTVVHHRFQGDTYRPQL---HFVKEKEI--F----Y-P--YDFTVTILGHD-
>tr|A0A0R2FW09|A0A0R2FW09_9LACO DfrA protein OS=Lactobacillus selangorensis GN=IV38_GL000334 PE=4 SV=1
----LIYLWAEDENHLIGANGTLPWH-LPADMHHFKTLTT-----G--QTVLMGRKTWDSLP--HGALKDRTNLVVTRQDNFAP-DAL-VLSGRVAIM--
-------HVDENIYVIGGSQIFELLKD-Q-VDQLEVTRIGASFDGDVYMPDL---AFKRIKQN--A----H-A--YPYTFETYTRV-
>tr|B4U362|B4U362_STREM Dihydrofolate reductase DhfR OS=Streptococcus equi subsp. zooepidemicus (strain MGCS10565) GN=dhfR PE=3 SV=1
----IIAIWAEDEAGLIGACGRLPW-YLPKELQHFKETTL-----N--QAILMGRVTFEGMK--GRLLPNRQTLVMTRDSYYV-E-AL-TITSVQEALHT
Q--D------KTLYVIGGSKVLEAFDGH--FDAIIKTVVHHRFEGDTYSPRL---DFVEETSV--L----Y-S--YDFTVTVLRHR-
>tr|A0A0M5JQA5|A0A0M5JQA5_STRTR Dihydrofolate reductase OS=Streptococcus thermophilus GN=ADU38_821 PE=3 SV=1
----IIAIWAEARNHVIGKNHTMPW-HLPAELAHFKKTTM-----G--SAILMGRVTFDGMN--RRCLPGRETLILTRDKDFC-E-VT-TVTSVEEALEQ
Q--D------KDLYIAGGAGVYKAFDGH--YDVLIKTTIEADLEGDTYFPQL---AFKEVSRD--R----V-A--YDFSISRYEKE-
>tr|A0A0R1SFI7|A0A0R1SFI7_9LACO Dihydrofolate reductase OS=Lactobacillus versmoldensis DSM 14857 = KCTC 3814 GN=FC27_GL000740 PE=4 SV=1
----IAFVWAEDSQRNIGYQGDLPWY-LPNDMKRFKELTT-----N--NTIVMGRRTYESFP--NGPLPNRQNIVISRNKNYVKSPAI-LINDKGALF--
-------SKQANIMIIGGKTIFQLFKD-D-VDTLYVTKIHHEFSGDTKMIDL---KFKLTEKK--E----G-P--YPYTFETYHRL-
>tr|A0A0R1KMS1|A0A0R1KMS1_9LACO Dihydrofolate reductase OS=Lactobacillus nodensis DSM 19682 = JCM 14932 = NBRC 107160 GN=FD03_GL001991 PE=4 SV=1
----ISFVWAEDKNHIIGKDGTLPWS-MPNDLKHFRDVTA-----H--HTIVMGRKTYESFP--NGPLPNRLNIVISRNPNYVPESVV-LLTDKNKLS--
--------DDTEVMVIGGAGIFEMFKD-D-VDRLYLTRIDHAFDGDVKMIDL---KFKLSEKK--E----G-I--YPYTFETYDKI-
>tr|A0A0R2LFT2|A0A0R2LFT2_9LACO Dihydrofolate reductase OS=Lactobacillus kimchiensis GN=IV57_GL001195 PE=4 SV=1
----ISFVWAEDKNQIIGVDGHLPWK-LPNDMKRFKDVTT-----G--HPIVMGRKTYESFP--NGPLPNRLNIVISKNSDYVPETVA-LLTDKSQLK--
--------ADEEVMVIGGEGIFKLFSD-D-VDRLYVTKIDHEFVGDTKMVKI---KFNLIEKK--E----G-I--YPYTFETYQRI-
>tr|A0A0H4QF17|A0A0H4QF17_9LACO Dihydrofolate reductase OS=Lactobacillus ginsenosidimutans GN=ABM34_02505 PE=3 SV=1
----IGFVWAEDDLGNIGINGHLPWK-LPNDMKRFKDVTT-----G--NTIVMGRKTYESFP--NGPLPNRKNIVISRDSSYVQKPAL-LVNTKQQLL--
-------TPDEQVMIIGGKTIFEMFKD-N-VDTLFVTKIHHSFDGDTKMIEI---EFKLIEKK--E----G-I--YPYTFETFKRL-
>tr|I7KG93|I7KG93_9LACO Dihydrofolate reductase OS=Lactobacillus hominis DSM 23910 = CRBIP 24.179 GN=BN55_03865 PE=3 SV=1
----IKMIWAQDLQRNIGYQGKIAWY-LPADLQHFKKETL-----G--HVMVMGSKTFTSLP---KVLPKRKHYVLTHHPEKDQIQVK-IFTDLAELK--
-------I-NDDVYVIGGRTIFDQFMD-L-ADELIVTQIDSTFKGDVKASQI---KFKVIDRE--F----Y-K--YDYEIIKYQKL-
>tr|A0A0R2KHB2|A0A0R2KHB2_9LACO Dihydrofolate reductase OS=Lactobacillus ceti DSM 22408 GN=IV53_GL000738 PE=4 SV=1
----LAYMWAEDQLGQIGYQGKLPWH-LPADLAHFKETTM-----N--HPMIMGRKTFASFP---KLLPGRKHLVLTRQAELEKYQVM-IFTDLPSLR--
-------NDELDPIIIGGASLFEIFKK-E-VQTLYQTQIQATFKGDTVMPQL---DFTLVQED--A----F-A--YDYVFKEYRRK-
>tr|A0A0R1ZQZ7|A0A0R1ZQZ7_9LACO Dihydrofolate reductase OS=Lactobacillus animalis KCTC 3501 = DSM 20602 GN=FC30_GL000198 PE=4 SV=1
----ISFIWAEDKAHHIGYQGKLPWH-LPADLAFFKKQTI-----G--HPIVMGRKTFASF---PGLLPKRQHVVLTHSEELKEAQTTEVFSDLTELK--
--------QSEEVFVIGGASLFNSLQE-E-VERLYVTKIAAEFKGDTLMPEL---KFKVIFQE--D----G-H--YPHTFYIYERK-
>tr|E1M807|E1M807_9STRE Dihydrofolate reductase OS=Streptococcus infantis SK1302 GN=folA PE=3 SV=1
----IVAIWAQDEKGVIGKEDRLPW-HLPAELKHFKETTL-----N--HAILMGRVTFDGMG--RRLLPGRETLILTRNPEEI-D-AL-VFQNVEDVLHH
Q--A------KNLYIIGGKQIFQLFEPY--LDEIIVTQIHAQVEGDTFFPSF---VFETVASK--S----Y-A--YDFTIEYRKRK-
>tr|A0A081QB19|A0A081QB19_STRMT Dihydrofolate reductase OS=Streptococcus mitis GN=dhfR PE=3 SV=1
----IVAIWAQDEEGVIGKDNRLPW-YLPAELQHFKETTL-----N--HAILMGRVTFDGMG--RRLLPKRETLILTRNSEEI-D-VT-TFYDVQSVLQA
Q--D------KNLYILGGKQIFQAFEPY--LDEVIVTHIHARVEGDTYFPEF---IFEIVSSK--F----Y-P--YDFTIQYRKRK-
>tr|I0T6M0|I0T6M0_STRMT Dihydrofolate reductase OS=Streptococcus mitis SK579 GN=folA PE=3 SV=1
----IVAIWAQDEEGVIGKDNRLPW-HLPAELQHFKETTL-----N--HAILMGRVTFDGMG--RRLLPKREILILTRNSDEM-D-VS-IFNDIESVLQA
Q--D------KNLYVIGGKQIFQAFEPY--IDEVILTHIHARVEGDTYFPEF---LFETVSSK--F----Y-P--YDFTIRYRKRK-
>tr|F5VTW2|F5VTW2_STROR Dihydrofolate reductase OS=Streptococcus oralis SK255 GN=folA PE=3 SV=1
----IIAIWAQDEKGVIGKENRLPW-HLPAELQHFKETTL-----N--HAILMGRVTFDGMG--RRLLPKRQTLILTRNSEEI-D-AL-VFQDVESVLQS
Q--E------KNLYIIGGKQIFQTFEPY--LDEIIVTQIHAQVEGDTYFPEF---RFETVASK--S----Y-D--YDFTIEYRDRK-
>tr|G5KFH2|G5KFH2_9STRE Dihydrofolate reductase OS=Streptococcus urinalis 2285-97 GN=folA PE=3 SV=1
----IIAIWAEDENGLIGVDGRLPW-RLPKELNHFKETTM-----G--QALLMGRVTFDGMN--RRVLPGRKTIILSKNLDLS-Q-IT-VLNSREAVLNH
Q--D------LDLFIIGGSKVFETFQND--FDAIIKTKVHGKFAGDTYFPTI---HFKEVSHQ--E----F-S--HDFTVHVYEKI-
>tr|J4KAM9|J4KAM9_STRAP Dihydrofolate reductase OS=Streptococcus anginosus SK1138 GN=folA PE=3 SV=1
----IVAIWAQDENGLIGRNNTLPW-HLPADLKHFKEMTT-----G--QAILMGRVTFDGMN--RRVLPNRTTIILTRDKSYA-ERVL-VFHDVDSVMET
Q--E------KTLYIIGGGQIFSAFEPL--IDELVITRIHASVQGDTYFPKF---KFQELSHQ--F----H-E--YDFTVTTFQRK-
>tr|T1ZDC9|T1ZDC9_STRIT Dihydrofolate reductase OS=Streptococcus intermedius B196 GN=folA PE=3 SV=1
----IVAIWAQDEDGLIGRDNRLPW-HLPADLKHFKETTT-----G--QVILMGRVTFDGMN--RRVLPNRTTIILTRDKSYV-EHVL-IFHDVTSVLEM
Q--E------KELYIIGGGQIFSAFGPF--VDEVVMTRIHASLQGDTYFPKF---KFQECSRQ--F----Y-E--YDFTVTTFQRK-
>tr|E7SB45|E7SB45_9STRE Dihydrofolate reductase OS=Streptococcus australis ATCC 700641 GN=folA PE=4 SV=1
----VIGIWAQTKNGVIGKDQVMPW-HLPAELQHFKQTTT-----G--HAILMGRVTYEGLN--KRVLPNRTNIILSRDDKYV-EEVL-LKTSVEDVLKG
Q--D------LSLFIIGGEKVIRLFEPH--LEELYQTVIDAELEGDTYFPEF---QFQLLDER--T----I-P--YDFTIRHFKRK-
>tr|A0A0F3H4M8|A0A0F3H4M8_STRPA Dihydrofolate reductase OS=Streptococcus parasanguinis GN=dfr PE=3 SV=1
----IIGIWAQTENGIIGKDQVMPW-HLPAELQHFKETTM-----G--QAILMGRVTFDGMK--KRVLPGRTSIILTQDQAYP-EAVL-VMHSKEEVLQN
Q--E------KNLYIIGGSQILKLFSDQ--LEELIQTMIHATIDGDTLAP-F---HYEKVSQV--P----H-P--YDFTVNYYKRK-
>tr|A0A0M9FFS8|A0A0M9FFS8_STRSU Dihydrofolate reductase OS=Streptococcus suis GN=XK27_08950 PE=3 SV=1
----IVAIWAQDENGLIGKGDRLPW-SLPADLAHFKETTT-----G--HTMVMGRVTFDGMG--KRALPNRHTIVLTTDKSYM-DRVT-ILNSIEEVLQQ
Q--D------GTLFVVGGSKIFTAFAPY--IDELIVTDIYGQFEGDIFFPKF---QFCLNNSK--F----R-A--FDFSIKTYERR-
>tr|A0A0M9FMW7|A0A0M9FMW7_STRSU Dihydrofolate reductase OS=Streptococcus suis GN=WQ51_03270 PE=3 SV=1
----IVAIWAQDENGLIGKGDRLPW-SLPADLAHFKETTT-----G--HTMMMGRITFDGMG--KRALPNRHTIVLTTDKTYL-ERVT-ILHSVEDVLNK
Q--E------QTLFVIGGGQIFTAFAPY--IETLIVTDIHGQFNGDVYFPKF---KFQLQSAN--L----R-P--YDFTIKTYERR-
>tr|A0A0E9GCY5|A0A0E9GCY5_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_3 PE=3 SV=1
----ISAVWAQDVNGVIGKNQTLPW-RMPADLQHFKETTM-----D--HVMVMGRVTFDGIG--GRVLPNRTSIILTRDKNFV-DDVK-VMHSVQEILEK
Q--E------QNLYVIGGAQVFRAFEPY--LDEIILTDIHDEYEGDTYFPSF---HFEEVGSV--F----R-A--SDFTVKYFARK-
>tr|A0A0H4IN99|A0A0H4IN99_9CAUD Dihydrofolate reductase OS=Pseudoalteromonas phage H101 PE=4 SV=1
----IKAILCVDKQGAIGQNGDMPWG-RSKDLAYFKKVTS-----E--GIVVMGSKTWKSLPF---GLPKRDNYVLTTQGRGQQGGVI-KLD---KCIES
--------NHKDTWVVGGASIYEQFADM--IDEWHITTIDNIYPEADTFF-----NFEDTLQY--S----D-DAT----VSVYRRK-
>tr|F3UB33|F3UB33_STRSA Dihydrofolate reductase OS=Streptococcus sanguinis SK1056 GN=folA PE=3 SV=1
----IIAIWAQAEDGLIGKDKVMPW-HLPAELQHFKATTT-----G--HAILMGRVTFDGLQ--RRVLPNRISLILSRDKNYV-DNVL-LFSNVEDVLHK
Q--D------RNLYIIGGAQIIRAFELY--LEELIQTQIAAKLEGDTYFPEF---PYQEVSSE--F----H-P--YDFTIKRYRRK-
>tr|A0A0E4H493|A0A0E4H493_9STRE Dihydrofolate reductase OS=Streptococcus sp. FF10 GN=dfrA PE=3 SV=1
----IVGIWAQDEQGVIGKNHVLPW-YLPAELHHFKETTI-----G--HNILMGRVTFDGMG--QRALPKRLSLILTRDTDYV-DRVL-VFHSPWAILEK
Q--D------KNLYVIGGKQIFTIFEPY--LDEILKTDIHASYEGDTYFPDF---VWAEVSSE--F----R-P--ADFTIRKYERK-
>tr|A0A0A0DEV7|A0A0A0DEV7_9STRE Dihydrofolate reductase OS=Streptococcus sinensis GN=SSIN_1632 PE=3 SV=1
----IIAIWAQAEAGLIGKDQVMPW-HLPAELQHFKRTTT-----G--HAILMGRVTFDGLN--RRLLPNRTSIILTNNQDYI-DNAL-VFNTIEDVLQH
Q--D------KNLYVIGGAQIIAAFEPY--LDELIQTQIAAKLDGDTYFPQF---LYREVSSE--F----Y-I--YDFTVKKYQRK-
>tr|G5JN53|G5JN53_STRCG Dihydrofolate reductase OS=Streptococcus criceti HS-6 GN=STRCR_1388 PE=3 SV=1
----IIAIWAQDESGLIGSKQTMPW-HLPAELAHFKKTTM-----G--QAVLMGRKTFDGMG--RRVLPGREILILTRDKTYV-D-VK-TVSSPEEVLSQ
Q--D------KDLYIAGGSGVYTAFRDY--YDGLVKTTIHACFEGDTYFP-I---DYQLVEQE--D----F-P--YNFTISKLNKI-
>tr|M3HP65|M3HP65_9STRE Dihydrofolate reductase OS=Streptococcus parauberis KRS-02083 GN=SPJ1_0046 PE=3 SV=1
----IIAIWAEDENGVIGVNGILPW-HLPKELQHFKKTTL-----N--HTILMGRVTFEGMQ--RRLLPNRQTIVLTSDDQYV-D-VL-TMTSVEQVLKT
Q--E------KNLYIIGGSKVLKAFDGH--FDKIIKTLVNHQFDGDTYSPEL---QFTEVNSQ--Y----F-P--YDFTVHVFENN-
>tr|B9DU71|B9DU71_STRU0 Dihydrofolate reductase OS=Streptococcus uberis (strain ATCC BAA-854 / 0140J) GN=dyr PE=3 SV=1
----IIAIWAEDENGVIGANGTLPW-YLPKELQHFKNTTL-----N--HAILMGRVTFEGMK--RRLLPNRQTLVLTSDESYV-D-AL-TMTSLEKTLHA
Q--E------NNLYVIGGQKVLQTFDGH--FNKIIKTVVHHQFDGDTYRPEL---PFVEEDCF--F----Y-P--YDFTVHILVRK-
>tr|V4Q7D4|V4Q7D4_STRIN Dihydrofolate reductase OS=Streptococcus iniae IUSA1 GN=IUSA1_09115 PE=3 SV=1
----IIAIWAQDEEGVIGRNGHLPW-YLPKELQHFKKTTL-----H--QAIVMGRVTFDGMK--KRLLPERQTIVMTSDHTYV-P-VL-TMSSLDAVLQS
Q--E------RTLYVIGGKKVLEAFDGH--FDRIIKTVVHHCFEGDTKAPNI---GFTEESQT--F----H-P--YDFTVYVYVKK-
>tr|A0A0A6S316|A0A0A6S316_STRUB Dihydrofolate reductase OS=Streptococcus uberis GN=NC01_04045 PE=3 SV=1
----IIAIWAEDKNGVIGVEGRLPW-RLPKELQHFKKTTL-----N--HAILMGRVTFEGMQ--RRLLPNRQTLVLTSDNKYV-D-VL-TMTSVEQVLHT
Q--E------KNLYIIGGSKVLKAFDGY--FDCIIKTLVDNEFTGDTYSPDL---GFEEVESQ--F----F-P--YDFTVHIFEKN-
>tr|A0A098CYA4|A0A098CYA4_9LACT Dihydrofolate reductase OS=Lactococcus garvieae GN=dhfR PE=4 SV=1
----IYAIWAEDEKKVIGIDGHLPW-RLPAELEHFKKTTY-----H--QAILMGRKTFEGMN--KRVLPGRITIVLTRDETYKEDRVL-IMHSVSEVVNN
Q--E------RDLYIIGGSEMFLLFENE--LSALYKTVVHGEFAGDTYFPDF---KYVKVSAD--Y----H-P--YDFTVEKYERK-
>tr|K2PSR7|K2PSR7_9LACT Dihydrofolate reductase OS=Lactococcus garvieae DCC43 GN=C426_2111 PE=3 SV=1
----IYAIWAEDEKKAIGIDGHLPW-RLPAELEHFKNTTY-----H--QAILMGRKTFEGMN--KRVLPGRVTIVLTRDRSYAEDKVL-IMHSVAEVLSS
Q--A------RDLYIIGGSEMFLLFENE--ISGLYKTVVHGEFTADTYFPDF---NYEKVSEN--R----R-P--YDFTVEEYKRK-
>tr|A0A0Q0QSB0|A0A0Q0QSB0_BACTU Dihydrofolate reductase OS=Bacillus thuringiensis GN=AL712_30140 PE=4 SV=1
----ISLIVAADENNAIGF-NKLLC-R-KDDMKHFIKKTK-----G--KPIIMGYKTFASL-G-HKPLKDRFNIVLTRSPM-LTLENL-VFESLEYIQ-I
E--Q---SKDKEIVVIGGQQTYELFLP-M-ASRVYLTRIHHSFPADSYFPML---EWSSKLDA--K----H-D--NDHPFSIYTFE-
>tr|G5JU47|G5JU47_9STRE Dihydrofolate reductase OS=Streptococcus macacae NCTC 11558 GN=folA PE=3 SV=1
----IVAIWAEDSHHLIGVQGKLPW-HLPKELKHFKETTM-----N--QALLMGRVTFDGMN--RRILPGRDTLVLTRDPQFA-E-VT-AVHSVKEALRQ
Q--D------KTLFIVGGASIYKAFENY--YDEIIRTSVQGQFEGDTYFPSI---HFQKISQR--F----F-A--YDFTVAVFKKK-
>tr|J3AJ80|J3AJ80_STRRT Dihydrofolate reductase OS=Streptococcus ratti FA-1 = DSM 20564 GN=D822_08542 PE=4 SV=1
----IIAIWAEDENGLIGADGRLPW-HLPKELKHFKETTT-----G--HALLMGRVTFDGMK--RRVLPNRETIILTRDQGFA-E-VK-ALNSPEEVLNS
Q--D------KNLYVVGGASIYKVFENY--YDELIRTKVHGRFLGDTYFPDF---GFKQTAST--D----F-A--YPFTITVWQKK-
>tr|V6Z0U0|V6Z0U0_STRAG Dihydrofolate reductase OS=Streptococcus agalactiae LMG 14747 GN=SAG0136_00840 PE=3 SV=1
----LIAIWAEDEQGLIGRNDRLPW-HLPKELKHFKETTM-----G--QVLVMGRVTFEGMN--RRILPGRQTIVLTRDLSYA-D-VI-VLHSKEEVLAQ
Q--D------KTLYIVGGASLYKSFLPE--VDGLIQTIVHGVFEGDTYFPDY---AFVAVSEI--Y----F-P--YDFSVTTYERK-
>tr|Q8DUI2|Q8DUI2_STRMU Dihydrofolate reductase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) GN=dfrA PE=3 SV=1
----IVAIWAEDDRHLIGVKGSLPW-HLPKELNHFKEMTM-----G--QALLMGRVTFDGMN--RRVLPGRDTLILTHDPQFA-E-VS-IVHSVPEALRQ
Q--D------KSLFIVGGASIYKAFESY--YDKIIKTSVHGQFEGDTYFPLR---SFQEISQA--F----F-S--HDFTVTVLEKK-
>tr|G6FET5|G6FET5_LACLL Dihydrofolate reductase OS=Lactococcus lactis subsp. lactis CNCM I-1631 GN=LLCRE1631_02028 PE=3 SV=1
----IIGIWAEDEAGLIGEADKMPW-SLPAEQQHFKETTM-----N--QVILMGRKTFEGMN--KRVLPGRISIILTRDETYS-DKVL-IMHSPKEVLHK
Q--N------KDLFITGGAEILALFESE--LELLYRTVVHEKFKGDTYFPSF---RFKLVSEK--F----H-S--YTFTIKKYEKV-
>tr|A8AXC0|A8AXC0_STRGC Dihydrofolate reductase OS=Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) GN=folA PE=3 SV=1
----IAAIWAQDQNGLIGRNQSLPW-HLPAELKHFKEITS-----G--HAILMGRVTFDGMD--QRVLPNRTSLILTKDPNYV-ESVL-IFHNLPSVLQE
Q--E------KNLYIIGGGQIFSLFQYH--LDEIIKTEIHASFEGDTYFPKF---AFREVNSQ--F----H-A--YDFTVKILERK-
>tr|A0A0F2CTD9|A0A0F2CTD9_STRCR Dihydrofolate reductase OS=Streptococcus cristatus GN=dfr PE=3 SV=1
----IAAIWAQDQNGLIGKDQSLPW-HLPAELKHFKEITT-----G--HVILMGRVTFDGMH--RRVLPNRKTLILTRDRDYI-ERVL-VFHDLSAVLQE
Q--E------KNLYIIGGGQIFSLFEHE--LDEVIKTEIHASLEGDTYFPTF---QFEEVSSR--F----R-E--YDFTVKILKRK-
>tr|F9HF47|F9HF47_9STRE Dihydrofolate reductase OS=Streptococcus sp. oral taxon 056 str. F0418 GN=folA PE=3 SV=1
----IAAIWAQDQNGLIGKDQTLPW-HLPAELKHFKEITT-----G--HAILMGRVTFDGMN--QRILPNRITLILTRDTGYI-DRVL-VFHDLASVLHQ
Q--D------KNLYIIGGGQIFSAFEHE--IDEIIKTEIHASLVGDTYFPEF---KFREISNH--F----H-E--YDFTVKILERK-
>tr|A0A0R2N1K5|A0A0R2N1K5_9LACO Dihydrofolate reductase OS=Lactobacillus saniviri JCM 17471 = DSM 24301 GN=IV56_GL001403 PE=4 SV=1
----ISFLWAQDQHGLIGKDGTLPW-HLPDDLHFFKSVTI-----N--QIMVMGRKTFEGMG--KKPLPNRTNIVLTHQPEY-SAGVI-VYHSAESVLAS
-------FPDKNLVIVGGAHVFASFK-----DVLYVTRLAGSF-GDTYMTDI---PFDLITSR--T------A--LTHTFEAWVRR-
>tr|A0A0R1ZVN8|A0A0R1ZVN8_9LACO Dihydrofolate reductase OS=Lactobacillus sharpeae JCM 1186 = DSM 20505 GN=FC18_GL000896 PE=4 SV=1
----IAYIWAQDARGTIGKNGTLPW-HLPDDLKFFKDQTR-----D--QIVVMGRKTFTGMG--ERPLPKRVNVVLTRQANF-TAGVH-VLHDKAAVLAA
-------HPEQHLMIIGGAEIYRLFA-----DTLYVTRLAGTF-GDTQMAAL---DFTRTTAR--T------A--LTHTFETWQRK-
>tr|A0A0R1TY06|A0A0R1TY06_9LACO Dihydrofolate reductase OS=Lactobacillus pantheris DSM 15945 = JCM 12539 = NBRC 106106 GN=FC50_GL001488 PE=4 SV=1
----TAFIWAQDRNRIIGRDGKLPW-HLSDDLQFFKATTL-----N--QAIIMGRKTFVGMG--SRPLPQRLNIVLTHQQDL-AVGVL-VVHSIQEALTD
-------AGHDTAFVIGGAGVFNSFVE----DRLFVTRIHGAV-GDTKMVEL---QYRRESAR--T------Q--LTHTFEEWVYA-
>tr|U2KG97|U2KG97_9STRE Dihydrofolate reductase OS=Streptococcus sobrinus W1703 GN=HMPREF1557_02090 PE=3 SV=1
----IIAIWAQDQAGLIGANQTMPW-HLPAELAHFKKTTM-----G--QAILMGRKTFDSMG--RRTLPGREILILTHDKTYV-D-VK-TVSSPEEALDQ
Q--N------KDLYIAGGAGVYQAFINN--YTGLVKTIIQARFEGDTYFPEM---PYQLVSEE--N----H-P--YDFTIATYQKL-
>tr|D3B6I5|D3B6I5_POLPA Dihydrofolate reductase OS=Polysphondylium pallidum GN=PPL_03733 PE=3 SV=1
----ISIITAVSTNYVIGKDGLLPW-SLPKDWEHFNRSTT-----N--YPIIMGKRTFY---EEDRPLPDRYTIVVTRDSS-DKHHLS-RASSIEDALDD
---Y----SGDQVFIVGGRRIYEDSL--YLATELIITHVEAHV-GDTHLRLFPH-YWDVVNQV--K----H-Q--YDFTIKYYQRS-
>tr|A0A0R1ZS11|A0A0R1ZS11_9LACO Dihydrofolate reductase OS=Lactobacillus malefermentans DSM 5705 = KCTC 3548 GN=FD44_GL001384 PE=4 SV=1
----FKFIWAEDSQHAIGNEGHLPWR-LPEDMHFFRDTTM-----N--HTLVSGSRTFESYG---RPLPHRKNIVMANNPEAFPEGVI-VMHSLDELL--
--------TDEAIFISGGATIFKLLLP-Y-VSELYVTKLDGTFTADTFMPEI---QFELIDSR--E----G-T--IPHRFEHYRRK-
>tr|R6AQ49|R6AQ49_9BACT Dihydrofolate reductase OS=Prevotella sp. CAG:604 GN=BN731_01115 PE=3 SV=1
----INIIACLDQNGAIGYKNQLLF-HIRKDMERFKQLTL-----N--HTIVMGRKTYDSLP--HGALPLRRNIVITQQEI---ENCE-VYHSLTDALTD
----------DIIFIIGGESIYKQCLN-L-ADNLYLTIVDKKMPADTYFPSINS--WEIIDKE--Q----H-I--FSFSFITFKNN-
>tr|A0A0G0FFS2|A0A0G0FFS2_9BACT Dihydrofolate reductase OS=Microgenomates (Roizmanbacteria) bacterium GW2011_GWA2_35_8 GN=UR89_C0026G0008 PE=3 SV=1
----ISIVAAMDENRGIGY-GKIPW-H-KEDLLRFKHLTV-----G--KTVIFGRKTYKSLLGSGRPMPTRNTIVVSRSFG-IALDLH-YASSVEEAIKK
---I----EPVEVFISGGGEIFNKGIK-Y-AEKLYLTIVKGRFQADTFFPDY----FEKVVFE--K----N-D--IKFKFVELSK--
>tr|A0A0G0GFR9|A0A0G0GFR9_9BACT Dihydrofolate reductase OS=Microgenomates (Roizmanbacteria) bacterium GW2011_GWC2_37_13 GN=US40_C0013G0022 PE=3 SV=1
----ISMIAAMDENRGIGY-GRIPW-H-REDLLRFKHLTT-----G--KTVIFGRKTYESLLGSGRPMPERKTIVVSRTIG-NETGIH-WANSIEEALRK
---I----EPEEVFISGGAQIFSQGIK-Y-AEKLYLTIVKGKFQADAFFPDY----FKVIK-E--E----K-K--YFFKFIELIK--
>tr|A0A0G0BR86|A0A0G0BR86_9BACT Dihydrofolate reductase OS=Microgenomates (Roizmanbacteria) bacterium GW2011_GWA2_35_19 GN=UR68_C0025G0018 PE=3 SV=1
----ISIVAAMDENRGIGY-GKIPW-H-REDLLRFKNLTV-----G--KTVIFGRKTYDSLLGSGRPMPTRRTIVVSRSSG-IASDLY-YVSSVEEAIKK
---I----EPVEVFISGGGEIFNQGIK-Y-AEKLYLTVVEGKFQADAFFPDY----FKNIISE--E----N-N--FKYKFVELVK--
>tr|Q8VVN6|Q8VVN6_VIBCL DhfR18 OS=Vibrio cholerae GN=dfr18 PE=4 SV=1
----FSMIVARGVNGEIGQDGDLPW-HLKEDLKRFKAITM-----G--KTLVMGRKTFESIP---NGLPGRNVIVLTREPY-ADIGTF-VAWGNSCHLAE
---H---LGVTEIIVAGGAEIYNLHKD-V-ITKVFETKVLRAYPVDVFWESPGY-TEGRTSRG--H----I-G--SFTIATTYER--
>tr|J7KJR5|J7KJR5_9CAUD Dihydrofolate reductase OS=Erwinia phage phiEaH2 PE=4 SV=1
----ISLIAAVDRNNVIGRSFALPW-R-PADLKNFKEVTM-----G--KTCIVGRKTWESFDS--TPLPGRKFIIITRHPD-Q-VSAI-GATSIGAAL-L
-------EGLNEVFIIGGAEIYHQCLP-M-AHAVYLSRIDLVVEGDVFFPDI---DFRLDVSL--T----H-R--WTYQIWNRIEK-
>tr|G5DEF1|G5DEF1_9CAUD Putative dihydrofolate reductase OS=Salmonella phage SPN3US GN=SPN3US_0058 PE=3 SV=1
----------MDRNNAIGKNNELPW-R-PADLANFKAITT-----G--KNVIMGSKTWESLGC--RPLPNRGNLIVTRNPE-I-NLVT-FHTSIDLAI-E
R-IE---GKEQEVMIIGGASVYQQTLA-R-ADRIYLSRIDIAVEADAFFPEI---VFQVDYTM--T----H-R--WTYQILNRIAG-
>tr|R6QQI9|R6QQI9_9BACT Dihydrofolate reductase OS=Prevotella sp. CAG:386 GN=BN637_01052 PE=4 SV=1
----ISLIACIAQNGAIGFHNHLLY-PIRQDMQRFKTLTT-----G--HTVIMGRMTYLSLP--NGPLPNRHNIIVSKTMR-QSAQYE-VCRSLEEALRD
-------QGEKEVFIIGGAMLYRSALS-L-ATRLYLTIVEDTPQADAFFPLTNQ--WKKVKEE--T----H-K--LTFRFVDLEKC-
>tr|A0A0K8MJR9|A0A0K8MJR9_9LACT Dihydrofolate reductase OS=Fructobacillus ficulneus GN=FFIC_284360 PE=3 SV=1
----IRMVWAEDDQHAIGKDGDLPW-H-PADLKHFKNETI-----N--TTMVMGRSTWDSI---GRPLPGRKTVVLTRNLD---PEVT-VVHSLADLKED
---Q---QAGKPVSIAGGAQVFNALMP-I-ATELSVTKVAGEYAGDTFVDPI---IFTLVNQE--S----H-D--YHFTFQTYQRK-
>tr|A0A059WUM4|A0A059WUM4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----VSLIVATDRNEAIGRHNRLPW-H-PADLQRFRALTT-----G--HVVVVGALTQQSIVGLGKALPDRVSVVVSRRMP-VISGVI-PAISIDHATQT
I-SR---KGIDEWFVIGGHQIYEQCLPQ--VSRVYRTLVDTVV-ADTFMPPN---DFALIETS---------D--LPITFETYDRS-
>tr|F8UVR4|F8UVR4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----LSAIVAVSDNDVMAKDGKIPW-FVRGEQLIFKRLTT-----G--PPIIMGRKTFETPKTKPMLLPDRLNIVISRNKN-V-PGGV-VVNSFDEALAV
-------KSASEAFVIGGSEIFEQAMP-K-IYKLYLTRVHTTIAGDKFFK-FNP--WKLTHKE--F----Y-P--YDFEFQIWQRR-
>tr|A0A059X0Z4|A0A059X0Z4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----ISLIVAASDNDVIAKDGKVPW-F-RGEQAIFKQVTM-----G--HPIIMGRKTYETAKTRPQLLPGRLNVIITRQPD-VPE--V-VAHSLDEALQ-
-------RAADEVFIIGGGEIFDMAMPL--ADKLYYTRVHTTI-GDKTFKFD---QWRLVSSK--L----H-P--YDFEFQEWVRA-
>tr|F8UVS5|F8UVS5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
-----MLVAAVADNGVIAQ-GALPW-N-PEDTEHYLRTV-R----H--HAVLLGRTTYDEIGG---PMPDCTTIVLTRDRR--RG--R-VAHDVATALRA
---S---HADRPLMVLGGAQVYALALA-G-AEEQVLTEVHVSPEGDTFYPDFDR-EW---TRR-EP----H-D--VPFEF-VWLSR-
>tr|A0A0G0LEP5|A0A0G0LEP5_9BACT Dihydrofolate reductase OS=Microgenomates (Woesebacteria) bacterium GW2011_GWB1_38_8b GN=UT10_C0025G0006 PE=4 SV=1
----FSIVVAIDEKRGIGKDNKIPW-HIKEDLVNLKNLTQ-----N--QVVIVGANTFISMQSSEREMPGKVYIVVTDDRG-P-SNAI-CVYSIDEAIKS
---Y----GTDEVFIIGGSQIFKQMI--KLANKLYLTIVKGDF-CDTFFPGYSD--FKNVISS--K----R-E--FEF--KILERI-
>tr|K2B7A7|K2B7A7_9BACT Dihydrofolate reductase OS=uncultured bacterium (gcode 4) GN=ACD_50C00344G0009 PE=3 SV=1
----ISIICAMDEKRGIGK-NKIPW-H-KDDLLKLKSLTK-----N--HVVILGRKTYDSMVGTGRPMPGKIYLVVTRDAN-KPANAA-TVTSVESAI-E
---E----QAEEVFVTGGAQIFQQVMH-L-TDKLYLTIVGGDYDCDTFFPDY----FRKVISE--E----S-G--HKYKFLELEK--
>tr|A0A098TM30|A0A098TM30_9CHRO Dihydrofolate reductase OS=Neosynechococcus sphagnicola sy1 GN=DO97_19870 PE=3 SV=1
----IIIAALAVGNRVIGSQGKVPW-C-PEDSQRFQQLTL-----G--HTVIMGRHTWEL-DL-RCPLPQRRNIVVSTSLTPLSPELQ-LAASLDEALKD
---------ADKIFIVGGAALYTAALPV--ADTLDLTLVEGTH-GDTFFPDY---EFTLVNQ----------C--SGYRFETYRRH-
>tr|A0A059X5R3|A0A059X5R3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----IIIAAVAESNRVIGR-GKLPW-R-PQDSKRFQEITL-----G--HPVIMGRKTWEFD-VEKRPLSKRFNIVVSSSPE-EDVELA-FVNSVQDAL--
-------VNQEKAFIVGGASIYSQALN-L-ADTLELTLVEGNFEGDTFFPDY----IGSQFK---L----V-H--PGFRYETYRRI-
>tr|K9WQX9|K9WQX9_9NOST Dihydrofolate reductase OS=Cylindrospermum stagnale PCC 7417 GN=Cylst_0455 PE=3 SV=1
----IIIAALAASNRVIGKNGKLPW-SIPADSQRFQNLII-----G--HAIIMGRKTWE---YDLEKRPAMFNVVISASTP-EIANLL-FVTSIQEAL--
-------SHHQQAFIVGGAFIYSQAL--NLADTWELTLVEGDF-GDTFFPEYEF-----GNQF--E----M-H--PGYRFETYKRI-
>tr|V4ZMV7|V4ZMV7_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HR67 GN=A07HR67_01488 PE=4 SV=1
----LVSVAAVAENGVIGD-GEVPWPH-AEDVEQYRERV-A----G--SPVILGRRTFDSMRG---DLPGSQQIVVSRSVE-VDE--A-VVGGVDEALRG
L--A----PDETVYVLGGGAIYGLFQP-H-VDAMVLSRIDGRYEGDTRFPEWDR-KW---TAE-TE----Y-T--LR----TWHRR-
>tr|M0NZ41|M0NZ41_9EURY Dihydrofolate reductase OS=Halorubrum kocurii JCM 14978 GN=C468_11565 PE=4 SV=1
----LVSVAALAENRAIGR-GEVPWPH-EADVRQYRERV-A----G--SPVILGRRTFDSMRD---DLPGSRQIVVSRSVN-VDV--V-VADGVDAAIAE
IAGG-----DDPVYVLGGGAIYELFQP-H-LDRMVLSHVAESYEGDTFYPAWDP-EW---AAE-SA----F-T--LR----EWARR-
>tr|M0PN12|M0PN12_9EURY Dihydrofolate reductase OS=Halorubrum arcis JCM 13916 GN=C462_07562 PE=4 SV=1
----LVSVAAVAENRVIGR-GEMPWPH-EADVRQYRERV-A----G--SPVILGRRTFDSMRG---DLPGSRQIVVSRSVD-VDV--T-VANGDEEAIRG
AAEV----GVDTAYVLGGGGIYELFQP-H-LDGMALSHVDGAYEGDTRYPEWDE-EW---TEE-TE----Y-T--LR----EWARR-
>tr|A0A0M9AQC7|A0A0M9AQC7_9EURY Dihydrofolate reductase OS=Halorubrum sp. 5 GN=AMR74_09920 PE=4 SV=1
----LVSVAALAENRVIGR-GEVPWSH-EADVRQYRERV-A----G--SPVILGRRTFDSMRD---DLPGSRQIVVSRSVD-VDV--S-VANGDEAAIRD
AVEA----GFGTAYVLGGGRIYDLFQP-H-LDVMALSHVDGAYEGDTYYPEWDD-EW---AAE-TA----Y-T--LR----EWVRR-
>tr|M0PJB5|M0PJB5_9EURY Dihydrofolate reductase OS=Halorubrum aidingense JCM 13560 GN=C461_01562 PE=4 SV=1
----LVSVAALAENRVIGR-GEVPWPH-EADVRQYRERV-A----G--SPVILGRRTFDSMRD---DLPGARQIVVSRSVS-VDV--V-VAGGAEEAIRR
ILDG---FPDGIVYVLGGGGIYDLFAP-H-VDRMVLSHVDGAYEGDTYFPAWDD-EW---ERE-TP----Y-T--LR----EWVRD-
>tr|M0DQP1|M0DQP1_9EURY Dihydrofolate reductase OS=Halorubrum saccharovorum DSM 1137 GN=C471_12011 PE=4 SV=1
----LVSVAALAENRAIGR-GEVPWPH-ETDVRQYRERV-A----G--SPVILGRRTFDSMRD---DLPGSRQIVVSRSVD-VDV--V-VADGVGSAIEE
IADR---SGGDPVYVLGGGTIYELFQP-H-LDRMVLSHVIGSYEGDTFYPAWDS-EW---ADE-TE----F-T--LR----EWVRR-
>tr|B9LSX5|B9LSX5_HALLT Dihydrofolate reductase region OS=Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) GN=Hlac_0438 PE=
----LVSVAALAENRAIGR-GEVPWPH-EADVRQYRERV-A----G--SPVILGRRTFDSMRD---HLPGSRQIVVSRSVE-VDV--V-VADGVDSALAE
ILAD---AADDTVYVLGGGGIYELFQP-H-LDRMVLSHVTGSYEGDTFYPAWDS-EW---AAE-TA----Y-T--LR----EWVRS-
>tr|A0A081EX88|A0A081EX88_9EURY Dihydrofolate reductase OS=Halorubrum saccharovorum GN=FK85_10425 PE=4 SV=1
----LASVAALAENRAIGR-GEVPWPH-EADVRQYRERV-A----G--SLVILGRRTFDSMRD---DLPGARQIVVSRSVD-VDV--V-VADGVDSAIEE
IAGA---DGDAPVYVLGGGTIYELFQP-H-LDRMVLSHVAGSYEGDTFYPEWDE-EW---ADE-SK----F-T--LR----EWVRR-
>tr|M0FK72|M0FK72_9EURY Dihydrofolate reductase OS=Halorubrum hochstenium ATCC 700873 GN=C467_04580 PE=4 SV=1
----LVSVAALAENRVIGK-GEVPWPH-EADVRQYRERV-A----G--SPVVLGRRTFDSMRD---DLPGSRQIVVSRSVD-VDV--T-VANDVEAALRE
VADD---DGDGVVYVLGGGTIYELFQP-H-LDGMALSHVDGSYEGDTYYPEWNE-EW---AAK-TD----Y-T--LR----EWVRR-
>tr|M0ENX5|M0ENX5_9EURY Dihydrofolate reductase OS=Halorubrum distributum JCM 9100 GN=C465_10277 PE=4 SV=1
----LVSVAALAENRVIGR-GEVPWPH-EADVRQYRERV-A----G--SPVILGRRTFDSMRD---DLPGSRQIVVSRSVE-VDA--V-VASGVEEALRD
LVADAEAGTDDHVYVLGGGAIYDLFQP-H-LDAMALSHVDGAYEGDTRYPEWDE-EW---AAE-TP----Y-T--LR----EWARR-
>tr|I1TQM2|I1TQM2_9CAUD Dihydrofolate reductase OS=Pseudomonas phage Lu11 GN=Lu11_0215 PE=3 SV=1
----LGIIFACDEAGGIGRDNTMPW-HFPEELKHFKAATY-----G--KPIILGRKTWESLG--CKTLPGRPHIVVSSNPK---DDVW-LAESFDTALEY
L--I---FESDIAWVIGGANLIQQALP-K-ASLVRITHVKGDFNTPAVFNHIMV--------N--R----L-V--KEFDIVEYAM--
>tr|G8DEL2|G8DEL2_9VIRU Dihydrofolate reductase OS=Phaeocystis globosa virus 14T GN=PGBG_00224 PE=3 SV=1
----VNVIVAYCKNGGIGINNTLPWK-ISSDLKKFKKMTL-----G--NAIVMGKNTWVSLRN---ALPSRDNLILSTSLDIDIVGYI-TKS---KLLVN
--------NYDELWIIGGENIYDLFLNK--TNKIVVTLIDKEVECDKYFP-----KYSFTSKT--I----H----YNVYDVMYIQ--
>tr|A0A0G1GUH4|A0A0G1GUH4_9BACT Dihydrofolate reductase OS=Parcubacteria bacterium GW2011_GWA1_44_13 GN=UW27_C0003G0018 PE=3 SV=1
----FEIIVAVAKDNVIGYKGQLPWGHLPRDLKHFRDITT-----G--HSIIIGYNTLNSLCRRTNLLPGRKIYVLTHDLQ---KDCI-GVSN----IVR
----------SRIFVAGGESIYHQFISLPQTRVVHMTRIIANYHGDTFFPLL---EWRSKKEE--F----H-K--HAMQFVTLMRA-
>tr|A0A0G1KCZ0|A0A0G1KCZ0_9BACT Dihydrofolate reductase OS=Parcubacteria (Azambacteria) bacterium GW2011_GWA1_44_9 GN=UW78_C0009G0009 PE=3 SV=1
----IEIIAAVADGGAIGHKGRMPW-DIPRDLTHFKEITM-----G--QTIVMGYTTLVSIG---RELSGRNVLALTRDPS-ASFKAT-TKD----VI-M
-------AKTERIIIAGGEATYLEFLR-Y-ATIAHITRIRKYF-GDTYFPELP--EWHLESSQ--F----W-----KGDKNPYPIE-
>tr|A0A0G0ZHA7|A0A0G0ZHA7_9BACT Dihydrofolate reductase OS=Parcubacteria (Nomurabacteria) bacterium GW2011_GWC2_42_20 GN=UV12_C0003G0028 PE=3 SV=1
----ISIITAMNDKRVIGNKGEMPWGRMLRDLEYFKKLTM-----G--FPVVVGYNTLVSISESTNLLPGRTLCVLTRDQN---KDCI-WLPD----VIN
----------IRVFIAGGENVYRQFIDLPEVRTIYMTRIIANYHGDTFFPNY---DWLTIQRE--N----H-K--HPLIFETLIRR-
>tr|A0A0R2BVZ8|A0A0R2BVZ8_9LACO Dihydrofolate reductase OS=Lactobacillus coleohominis DSM 14060 GN=FC35_GL000823 PE=4 SV=1
----ISFVWAEDEAGWIGKNGQLPW-H-PVDLKHFKTVTD-----H--HPIVMGARTFASI---GRPLPNRPNIVVSHHPV---DQVI-TVTNIEDLMFK
---R---ADQEEVCIIGGARLFAQMVA-H-VNCLHRTIVMGNHHGDVKMIPI---QWQLTKKT--P----V-A--LSCYFEEWVLD-
>tr|A0A0R1UHX1|A0A0R1UHX1_9LACO Uncharacterized protein OS=Lactobacillus equigenerosi DSM 18793 = JCM 14505 GN=FC21_GL000099 PE=4 SV=1
-------MWAEDLTGGIGYQGQLPW-H-PADLAHFKTVTM-----G--KTIVMGGRTWRAIG--R-ALPGRTSVVLTRQPL-P--GVM-VVHDEAQLHAE
---R---RQLEPVAIIGGATLFALLQA-Q-VDVLERTVIEATYP-DTKMPKLDE-AWTLVNQT--T----L-----KLRFETWHRL-
>tr|G6ETQ0|G6ETQ0_LACDE Dihydrofolate reductase OS=Lactobacillus delbrueckii subsp. bulgaricus CNCM I-1632 GN=LDBUL1632_00596 PE=3 SV=1
----LSYVWAEDEKGAIGYQGRLPWH-LPADLAHFKAKTM-----G--HPMLMGRKTFESL---PGLLPGRQHVVLSTR-KLLPAGVL-QLKSEEEVS--
--------QAGEVCVIGGSSLFALLAD-Q-VDKLEVTRIKGIFSADTYMPNL---AFALVKSE--A----H-K--YDYVFETYLRK-
>tr|A0A0R1X470|A0A0R1X470_9LACO Dihydrofolate reductase OS=Lactobacillus panis DSM 6035 GN=FD32_GL001115 PE=4 SV=1
----ITYVWAEDLDGWIGKDGSLPW-H-KADMQHFKRVTA-----D--HPVVMGRRTFDSI---GRPLPGRQNIVLTHREI---KRVV-SFQNLADLKKE
---N----SAPVVDIIGGGRLFTELMS-L-VTVLHRTIINGHYEGDTKMPPV---QWHLQDRQ--T----V-Q--PVCWFEEWQLN-
>tr|C2ESE4|C2ESE4_9LACO Dihydrofolate reductase OS=Lactobacillus vaginalis DSM 5837 = ATCC 49540 GN=folA PE=3 SV=1
----VNFIWAEDLDGWIGKDNQLPW-H-SADLKHFRKLTA-----N--HPVIMGRKTYNSI---GQPLPHRQNIVLTHQSI---DQIT-VVHDVETLDDV
---L----PDNQVYVIGGARIFSLMMP-L-VNKLERTIINGHYNGDVKMPPI---QWHLLKRD--E----V-Q--TSCWFETWELN-
>tr|A0A0R1PBZ8|A0A0R1PBZ8_9LACO Dihydrofolate reductase OS=Lactobacillus frumenti DSM 13145 GN=FD27_GL000813 PE=4 SV=1
----IHYIWAEDLDGWIGKNNQMPW-H-SADMKRFKQLTT-----G--HPVIMGRHTYNSL---KRPLPNRQNIVLTHQAI---DDVT-VVHDVETLDDA
---L----PDDQVYVIGGARIYDLLRG-M-VTNLDRTVINGHYDGDVKMPPI---QWQLQDRT--A----I-D--IECWFETWQLD-
>tr|C8P8Q5|C8P8Q5_9LACO Dihydrofolate reductase OS=Lactobacillus antri DSM 16041 GN=folA PE=3 SV=1
----VNFVWAEDLDGWIGKDHDLPW-H-SADLRHFKRETV-----G--RPVVMGRRTYESI---GRPLPHRENVVLTHHPV---GRVQ-SLATTADFKAR
---T----PEQEVAVIGGAQIFAQLLD-Q-ATVLTRTVINGHYAGDTKMPPI---RWQLVDRQ--P----V-Q--VACWFEKWVLN-
>tr|H1LG50|H1LG50_9LACO Dihydrofolate reductase OS=Lactobacillus kisonensis F0435 GN=HMPREF9104_01576 PE=3 SV=1
----ISYIWAEDANGIIGANGSLPWH-LPDDMAYFKSTTM-----G--NPIISGANTFRSY---NRPLPGRQNIVVSRQ--NFPDGII-AVSSIESLC--
-------APDKNYFVTGGATIFTQLLD-K-VDYLYRTKINHSFNGDTYMPKI---KFRLIRSQ--P----G-K--YQHTFEVYERI-
>tr|A0A0R1S149|A0A0R1S149_9LACO Dihydrofolate reductase subunit OS=Lactobacillus parakefiri DSM 10551 GN=FD08_GL002606 PE=4 SV=1
----LSFIWAEDANGLIGAAGQLPWR-LPDDMHYFKRTTM-----G--NTIISGSRTFRSY---NKPLPGRTNIVISSH--SFPDGVQ-VISSIEKLC--
-------NPDKQYIVTGGANLFSQLLS-R-VDRLYRTKIAHEFSGDTFMPKI---LFKQVKSV--P----G-K--YPHTFEVFDRK-
>tr|J9W5E3|J9W5E3_LACBU Dihydrofolate reductase OS=Lactobacillus buchneri CD034 GN=dfrA PE=3 SV=1
----LAFIWAEDANGLIGANGQLPWH-LPDDMHYFKETTM-----G--NTIISGSKTFRSY---NRPLPGRENIVVSHQ--TFPTGVK-VIPSIEQLC--
-------NPDKQYIVTGGANLFAQLRS-K-VDRLYRTKIEAEFSGDTYMPAI---LFELSKSV--V----G-K--YPHTFEVFDRK-
>tr|G9ZSD3|G9ZSD3_9LACO Dihydrofolate reductase OS=Lactobacillus parafarraginis F0439 GN=HMPREF9103_02652 PE=3 SV=1
----LSFIWAEDKNGLIGANGTLPWH-LPDDMKFFKKTTT-----G--NPIIAGARTFHSF---KRPLPNRQNIVLSKH--GFPDGVL-VISSIDQLC--
-------YPGKNYIVVGGASIFEQLMD-R-VDRLYRTKIDHVFQGDTYMPKV---AFKQIQSL--P----G-R--YPHTFELFERR-
>tr|C0WTJ8|C0WTJ8_LACBU Dihydrofolate reductase OS=Lactobacillus buchneri ATCC 11577 GN=folA PE=3 SV=1
----ISYIWAEDENGLIGASGNLPWH-LPDDMAFFKKTTM-----G--HPIISGARTFRSY---NRPLPGRQNIVLSRH--GFPDGVL-VISSVEQLC--
-------NPKENYFVTGGANLFGQLLD-K-ADRLYRTKIHHQFTGDTYMPEI---QFNQVTSI--D----G-R--YPHTFEVFERT-
>tr|A0A0A6RE81|A0A0A6RE81_9LACO Dihydrofolate reductase OS=Lactobacillus curieae GN=PL11_04910 PE=3 SV=1
----ISFIWAEANHGVMGNHGTLPWK-LPDDMKYFKDTTM-----G--NPIVSGSRTFRSY---NRPLPGRDNYVISTH--NFPEGVI-VLSSIDSFL--
-------NGDKEFFVTGGANIFKQLLG-S-VDRLYRTKIDHDFSGDTYIPEI---QFDLLSET--Q----G-Q--YPHKFQIFVRN-
>tr|A0A0R1N727|A0A0R1N727_9LACO Dihydrofolate reductase OS=Lactobacillus rapi DSM 19907 = JCM 15042 GN=FD12_GL000383 PE=4 SV=1
----ISYIWAEDANGLIGTKGGLPWH-LADDMKYFKNTTM-----G--HPIISGANTFRSY---NRPLPGRQNIVVSRK--TFPAGVL-VISSISELC--
-------NPNENYFVTGGANIFSQLLD-K-VDRLYRTKIDHSFTGDTYMPEI---DFKLAKSV--D----G-P--FPHTFEVYDRK-
>tr|A0A0R1SCI8|A0A0R1SCI8_9LACO Dihydrofolate reductase OS=Lactobacillus diolivorans DSM 14421 GN=FC85_GL001241 PE=4 SV=1
----ISFIWAEDENGVIGSSGKLPWH-LPEDMKYFRQTTM-----G--HAIVSGSRTFRSY---NRALPGRENIVLSSK--DFPDGVV-VIHSVKELC--
-------HPDKNYFVTGGANLFSQLRN-Q-VDRLYRTKIHHTFKGDTVMPTI---KFSKIQSI--I----G-K--YPHTFEVYQKT-
>tr|X0P961|X0P961_9LACO Dihydrofolate reductase OS=Lactobacillus farraginis DSM 18382 = JCM 14108 GN=FD41_GL000465 PE=3 SV=1
----ISYIWAEDEHGLIGASGKLPWH-LPDDMAFFKKTTM-----G--HPIISGARTFRSY---NRPLPGRQNIVLSRH--GFPDGVL-VVSSIEQLC--
-------NPQKNYFVTGGANLFSQLLD-K-VDRLYRTKIHAQFTGDTYMPKI---QFKQVKKH--P----G-H--YAHTFEVFDRI-
>tr|A0A0R1KWJ0|A0A0R1KWJ0_9LACO Dihydrofolate reductase subunit OS=Lactobacillus sunkii DSM 19904 GN=FD17_GL000696 PE=4 SV=1
----LSFIWAEDAKGLIGASGQLPWH-LPDDMHYFKRTTM-----G--NTIISGSRTFRSY---NRPLPGRENIVVSSQ--KFPDGVQ-VISSIEKLC--
-------HADKEYIVTGGANLFSQLLS-R-VDRLYRTKINAEFDGDTYMPPI---LFDKVKSI--P----G-K--YPHTFEVFERK-
>tr|S4NF21|S4NF21_9LACO Dihydrofolate reductase OS=Lactobacillus otakiensis DSM 19908 = JCM 15040 GN=FD05_GL001256 PE=3 SV=1
----LSFIWAEDANGLIGAAGQLPWH-LPDDMHYFKQTTM-----G--NTIISGSRTFRSY---NRPLPGRENIVVSSQ--TFPAGIE-VVSSIARLC--
-------NPDKEYIVTGGANLFSQLLS-Q-VDRLYRTKIDATFSGDTYMPAI---LFDQIKSV--K----G-K--YPHTFEVFERK-
>tr|A0A0R1YYN1|A0A0R1YYN1_9LACO Dihydrofolate reductase subunit OS=Lactobacillus parabuchneri DSM 5707 = NBRC 107865 GN=FC51_GL000281 PE=4 SV=1
----LAFIWAEDSHGLIGQNGTLPWH-LPDDMHYFKKTTM-----G--NTIISGSRTFRSY---NKPLPGRENIVISSQ--SFPAGVH-VVPSIDRLC--
-------NPTKEYIVTGGANLFSQLLT-R-VDRLYRTKIEGTFVGDTYMPPI---QFALVKSI--P----G-K--YPHTFEVYERR-
>tr|A0A0K8MJW8|A0A0K8MJW8_9LACT Dihydrofolate reductase OS=Fructobacillus fructosus GN=FFRU_020680 PE=3 SV=1
----LRMVWAEDDRHAIGKDGQLPW-R-PADLKHFKNETL-----H--STMLMGRATWDSI---GRPLKDRHTVVLTRQQD---PEVT-VVHSLEELQRA
---E---AKDHLVTVAGGAQLYKALLP-T-ATELSITKVAGDFDGDTFMEPV---DFTLVNQV--E----M-G--HEIKFLTYKRK-
>tr|A0A0J5SB44|A0A0J5SB44_9LACT Dihydrofolate reductase OS=Fructobacillus sp. EFB-N1 GN=dfrA PE=3 SV=1
----VKMVWAEDDRHAIGKDGDLPW-S-PSDLKHFKKETV-----G--STMVMGRATWAAI---GRPLPKRKTVVLTRQVD---PEVA-VVHSLADLQDD
---E---SQGHVVTVAGGAQVFTALMP-M-ATDLIVTKVRGDFDGDTFVSPI---QFTLTAQQ--E----A-D--YQLTFLTYKRK-
>tr|A0A0K8MPN2|A0A0K8MPN2_9LACT Dihydrofolate reductase OS=Fructobacillus pseudoficulneus GN=FPFC_010420 PE=3 SV=1
----VRMVWAEDDRGAIGKDGTLPW-H-PSDLAHFKEQTL-----N--STMVMGRSTWESI---GRPLPKRHSVVLTRQTD---PEVT-VVHSLEDLEQD
---E---AAGRLVTVAGGAQLYKQLMP-M-ATELSVTKVQGDFDGDTFMEPV---DFDLVDQR--T----A-D--YQLEFLTYKRQ-
>tr|V7HZ46|V7HZ46_9LACO Dihydrofolate reductase OS=Lactobacillus equi DPC 6820 GN=LEQ_2267 PE=3 SV=1
----LMFVWAEDKAHNIGYQGHLPWH-LPDDLAYFKKVTM-----G--HPMIMGKTTFASFP---KLLPGRLHVVLTHQKDLV-EQLI-LVHNFVELQ--
-------HQDQEIAVIGGAGLFELLKD-Q-VEILHKTEIQGVFPADTKMVAL---QFEEISRT--P----G-Q--YAHDFVVYQRR-
>tr|A0A0F4KRD1|A0A0F4KRD1_9LACO Dihydrofolate reductase OS=Lactobacillus mellis GN=dfrA PE=3 SV=1
----LAFLWAEDQRHLIGNQGHLPW-HLPNDLHYFKSVTW-----Q--QTIVMGHRTFTSLP--HGALPQRQNIVLSHDHNLL-P-VQ-MIYSKAELLA-
-------ATSKKIFVIGGSNVFAQLRA-E-VDYLYVTKIAHQFVGDVYMPP----DFQLISRR--Q----G-P--WPHEFLVYQRY-
>tr|C4VL55|C4VL55_9LACO Dihydrofolate reductase OS=Lactobacillus jensenii 269-3 GN=folA PE=4 SV=1
----ISFVWAEDNQHQIGYQGHLPWH-LPADLAHFKEKTM-----G--KTMVMGKNTFLSLP---FVLPKRKHLVLTHDEALEKFQVD-FVTSMKQLR--
-------HKEEQIAVIGGVSVFEGLKD-I-VDCLEKTEIDGIFKADTTMPAI---AFKLIKRE--T----F-P--YDYSFLTYLRK-
>tr|A0A0R1S829|A0A0R1S829_9LACO Dihydrofolate reductase OS=Lactobacillus psittaci DSM 15354 GN=FC23_GL000609 PE=4 SV=1
----ISFVWSEDNEHQIGYQGHLPWH-LPADLAHFKKKTM-----G--KTMIMGKNTFLSLP---FVLPKRKHLVLTHDQELAKYEVD-FVTSMKELK--
-------HQADQLVVIGGVSVFDGLKD-W-VDCLEKTEIDGTFKADTKMPTI---AFTLVKKE--N----F-P--YNYSFLTYLRK-
>tr|A0A0R1M075|A0A0R1M075_9LACO Dihydrofolate reductase OS=Lactobacillus capillatus DSM 19910 GN=FC81_GL001357 PE=4 SV=1
----LAYIWAEDEKHHIGYQGHLPWK-LPADLAYFKKQTA-----Q--HTIVMGRKTFESFK---GFLPHRQHIVLTTATDFAKYRLT-VVNSLTELR--
--------KDELFFVIGGTALFKQLLD-D-VDYLYVTKINAAFKADTIMPQI---QFELVSEV--D----G-L--YRHQYKVYRRK-
>tr|A0A0R2FR18|A0A0R2FR18_9LACO Dihydrofolate reductase OS=Lactobacillus mali GN=IV36_GL002343 PE=4 SV=1
----LAYIWAEDEQHHIGIDGHLPWS-LPADLAYFKVVTK-----N--HPIVMGRRTFDSFP---GFLPKRHHYVLTRSIAFDKYRIT-VVNNIEDLK--
-------EDSD-VFIIGGASLFAEFAD-T-VDLLYVTRIKGKFSGDTTMPEL---AFKLIKKV--P----G-K--FPHVFEVYQRK-
>tr|A0A0R1VCA8|A0A0R1VCA8_9LACO Dihydrofolate reductase OS=Lactobacillus satsumensis DSM 16230 = JCM 12392 GN=FD50_GL000199 PE=4 SV=1
----LAYIWAEDRKHQIGVAGHLPWQ-LPADLAYFKKTTA-----Q--HPIVMGRKTFASLP---GVLPHRHHYVLTRSAAFDKYQVT-VVHTLADLR--
--------ETQLIFIIGGASLFAAFAD-E-VDYLYVTEIDAEFTADTKMPEL---DFELISAT--Q----G-P--YAHSFKVYRRK-
>tr|F7QXV4|F7QXV4_9LACO Dihydrofolate reductase OS=Lactobacillus ruminis SPM0211 GN=LRU_00239 PE=3 SV=1
----LAYIWAEDSAHHIGINGRLPWH-LPNDLAYFKRQTS-----G--HPMIMGKKTFDSFP---KLLPGRLHVILTHSIEFKEYQVV-VVHNENDLR--
-------HDSEITFVIGGASLFKMFKD-D-VDLLYVTKIKEKFDADTTMPDL---RFALKYEE--K----G-Q--YQHTFFVYERK-
>tr|A0A0R1MH13|A0A0R1MH13_9LACO Dihydrofolate reductase OS=Lactobacillus oeni DSM 19972 GN=FD46_GL001489 PE=4 SV=1
----LAYIWAEDRNHHIGIAGHLPWS-LPADLAYFKKMTS-----N--HPIAMGRKTFESLP---GILPHRHHFILTRSESFQKYQIS-IVHSVEELR--
--------ESGLVFIIGGASLFAQFAS-D-VDYLYVTQIDAQFAADVTMPPL---DFELLSQE--E----G-R--YPHTFKVYRRK-
>tr|A0A0R1MKJ2|A0A0R1MKJ2_9LACO Dihydrofolate reductase OS=Lactobacillus hordei DSM 19519 GN=FC92_GL000014 PE=4 SV=1
----LAYIWAEDEQHHIGIDGHLPWT-LPADLAYFKSVTK-----N--HPIIMGRKTFDSFP---GFLPKRHHYVLTRSTDFDEYRIT-VVNNVEALV--
--------EDEDIFIIGGASLFAEFAN-K-VDLLYVTRIKGEFSGDTIMPEL---TFKLIKKV--D----G-K--FPHVFEVYQKK-
>tr|A0A023CUH7|A0A023CUH7_9LACO Dihydrofolate reductase OS=Lactobacillus sucicola DSM 21376 = JCM 15457 GN=FD15_GL002009 PE=3 SV=1
----LAYIWAEDAEQHIGYQGHLPWK-LPSDLAYFKKKTA-----H--HPIVMGRKTFESFK---GFLPQRQHIVLTTSTEFKKYRLT-VVHSITELR--
--------KDEVFFVIGGAALFEQLMD-D-VDYLYVTKIKAVFKADTSMPPV---DFELVAKS--D----G-L--YDHEFRVYRRK-
>tr|A0A0R2CH91|A0A0R2CH91_9LACO Dihydrofolate reductase OS=Lactobacillus cacaonum DSM 21116 GN=FC80_GL000980 PE=4 SV=1
----LAYIWAEDKEHHIGLNGHLPWH-LPADLAYFKKITK-----N--HPIVMGRKTFDSFP---GLLPQRHHFVLTNSIDLTKFRIT-VMNNIDDLS--
-------K-DL-IFIIGGASLFAEFAD-K-VDFLYVTRINSIFPGDTKMPII---LFELITKK--N----G-K--YPHVFEVYQRK-
>tr|A0A0R1W7D9|A0A0R1W7D9_9LACO Uncharacterized protein OS=Lactobacillus concavus DSM 17758 GN=FC15_GL000961 PE=4 SV=1
----LSYIWAEDRTGVIGDRGRLPW-H-PTEMHHFTVLTT-----G--HPIIMGARTFRSFP--KGPLPNRRNLVLTHQPA-LGQGIE-VIHDVESIYDA
-------EPAEEFFVIGGNSLFESLLP-L-VDKLYQTQIDHDYR-DVRMIPIPW-QFELVRQR--Q----L----PALTFNEYRRI-
>tr|A0A089Y1B1|A0A089Y1B1_9LACO Dihydrofolate reductase OS=Lactobacillus sp. wkB8 GN=LACWKB8_1043 PE=3 SV=1
----ITFVWAEDQQHQIGIEGHLPWK-LPLDLHHFKEITY-----G--HPIIMGRKTFMSLP---KILPGRKHVVLTTSKELRKYNVV-IVQSKNELQ--
-------HKNQNLCVIGGNSVFKALIK-Q-ADYLEKTAIKATFTADTTMIPI---EFSLVKKE--S----H-K--YSFDFLTYKRK-
>tr|A0A0F4LJE6|A0A0F4LJE6_9LACO Dihydrofolate reductase OS=Lactobacillus kimbladii GN=folA PE=4 SV=1
----ITFVWAEDEKHQIGLDGHLPWK-LPADIHHFKKITY-----G--HPIVMGRRTFMSLP---HILPGRKHIVLTTSQKLNKFRVL-IISTLTELQ--
-------HKNLEICVIGGNSVFDALKN-Q-VDCLEKTEIKATFIADVTMTKL---HFKIVKRE--F----H-L--YPYEFLTYMRK-
>tr|A0A0F4LGG5|A0A0F4LGG5_9LACO Dihydrofolate reductase OS=Lactobacillus melliventris GN=folA PE=4 SV=1
----ITFVWAEDQKHQIGIDGHLPWK-LPADLHHFKKITY-----G--HPIVMGRKTFVSLP---HLLPGRKHVVLTTSLTLNKYQVS-IIKSVKELQ--
-------HKQQNLFVIGGNSVFNALKN-Q-VDCLEKTEIIATFKADVTMTKI---DFILVKKG--F----H-L--YPYKFLTYMRK-
>tr|R5D8Q4|R5D8Q4_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:555 GN=BN705_01373 PE=4 SV=1
----MDAIVAVYSDWGIGAGGTQPVV-LKADRAQFKRVTD-----G--KTVIVGRRTLADFP-NGRPLKGRRNIVVTRQNI-ID-GAF-VAHSVAEAAC-
----------EATVVIGGASVYRDFFPL--IDRVFVTKIDLCPVSDSFFPNLDECDWQLVDNGEE-----LHEGDIAYRFTVYERK-
>tr|A0A059X062|A0A059X062_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----IRLIAAIDNKLGIAKNGTLPW-T-PVEQHYFKEMTMR---HG--GIVLMGRRTYETIG---RPLPGRQNFVLSSTLQ-TDG-IT-VVRDLKTFL--
-------E-QPDVWVMGGASVYEQTFE-Q-ADELYITRIDADF-CDQFFPAFAT-AFYLQRRS--P------N--LNYLYEIYSRP-
>tr|A0A059X847|A0A059X847_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LSAIVAASDNDVIGNQGKVPW-F-KGEQQRVKEITW-----G--QPLIMGRKTHES---IGRTLPGRLNVVISRDPQ-PYT--I-AVSSINSALE-
-------KAANEAFIFGGEKIYELAMPQ--LDKIYLTRVHADL-GDSFFKFD---DWKVISQE--N----Y-P--YDFDYLVLERK-
>tr|M4QQ97|M4QQ97_9VIRU Dihydrofolate reductase OS=Vibrio phage PWH3a-P1 GN=VPIG_00104 PE=3 SV=1
----IKMVVCSDKYGGIGLNNKLPW-H-PEDLEYFKEQTL-----Y--KTVVMGRKTFESLP-FEHGLPLRENVVLTNLFK-TYCNKT-LY--GLLQY--
-------ETKRDIWIIGGKSIYDQLLP-F-VEEIHHTVISGEY-CDTFMDVTQW-DWELKETK--V------A--KVYIW--R-K--
>tr|I4AP56|I4AP56_FLELS Dihydrofolate reductase OS=Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4) GN=Fleli_3421
----ISIITARSKNGVIGS-NSLPW-K-PSDMRFFKQTTI-----G--HHVLVGRKTYQSF-N--VQLVERPALILTTKSD-QPKEDQ-TINSLEEGI-K
---E---QNETELFIIGGGEIYKQALDKNLVTNMYITELDAIIEGDTFFPNF---EWNVVRND--S----F-D--YDYSFVLYEKK-
>tr|K9WDX1|K9WDX1_9CYAN Dihydrofolate reductase OS=Microcoleus sp. PCC 7113 GN=Mic7113_2650 PE=3 SV=1
----KIIIAAKTVNNVIGKDNSLPW-H-PADLDFFLRTIE-----G--QFLIAGRKFFESVQG-EVFHKGVEGIVISRQKD-SS-THP-VAHSIEEAFE-
-------IGVPKVYILGGGEIYQQIINL--VDRLIITEIHENF-GDTFFPEI---QWQEVSRI--D----C-P--YNYSFVVYEPA-
>tr|A0A0B0QKB0|A0A0B0QKB0_APHFL Dihydrofolate reductase OS=Aphanizomenon flos-aquae 2012/KM1/D3 GN=OA07_15690 PE=4 SV=1
----ISLIAAISENRILANSSGNPW-N-PSDEIYYRQMI-R----R--HPVIIGRKSYSTMNK---PFPDCTTIVLTRDTD-QAFGCV-VLHSLTEAIEM
---S----ETEEIFIAGGGQIYTEAIK-F-ADKLYLTIVEGNFVGDIYFPEFAD-G---VTKE-KK----M-G--YKFNF-VEIEK-
>tr|K7VVY1|K7VVY1_9NOST Dihydrofolate reductase OS=Anabaena sp. 90 GN=folA PE=4 SV=1
----ISLIAAISENRILSDSAGIPWN-IPSDELYYRETIR-----R--HPVIIGRKSYATFNK---PIRNCTTIILTRDTNFQAFGCV-VLHS--EAIK-
--------ETEEIFIAGGGQIYTEAIKL--ADKLYLTIVEGNFVGDIYFPEF-A-TKEKKMQ----------G--FKFNFVEIEKC-
>tr|A0A0R2NKM2|A0A0R2NKM2_9LACO Dihydrofolate reductase OS=Pediococcus argentinicus GN=IV88_GL000081 PE=4 SV=1
----LTMIWAEDLKHGIGK-GKIPW-H-PDDVKFFKEQTI-----G--NTVIMGRKTFDSI-G--KPLPRRQNIVLTHHKN-LPE--V-AYDDFGAVT-N
---N---NQEQHFIIIGGQAIYQKFIE-Q-SDQLLVTKVNQDFKCDTFAPAI---FKKSKSVT--V----L-----EHTFETWVK--
>tr|A0A0F9W7W2|A0A0F9W7W2_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_0043010 PE=4 SV=1
----LTLIVAHDKNRAIGRQGDIPWR-APEDLAAFQRETV-----G--GALIMGRLTWDSLP--RRPLPGRMNIVVTRAVQ--D--AP-SAQTPFEAVED
-------MGYQRIYGIGGAGIYTALLP-L-ADRLLITEVDLEVEADTFFPKVA-QDWRETGRY--A----L----PLLLQKEYLRA-
>tr|A0A0P0EVH4|A0A0P0EVH4_AZOBR Dihydrofolate reductase OS=Azospirillum brasilense GN=AMK58_13780 PE=4 SV=1
----ISLVVAA-RNGVIGRDGTLPW-SLPGDLKRFRELTM-----G---PVLMGRRTWESLPR--KPLPGRDNLVVSRSHPAGERGAR-WFGGLDAALHS
---R----GVPEVAVIGGAELFRETL--PL-DIVHLTRVED---GDTVMPPL-GPEWVE-ER--GP----------DYRYLDLVRR-
>tr|U5QKZ6|U5QKZ6_9CYAN Dihydrofolate reductase OS=Gloeobacter kilaueensis JS1 GN=folA PE=3 SV=1
----LTAVVATDRNRLIGRDNDLPW-D-PEELQAFKQLTI-----G--QTLLMGRQTFESIVKRKAPLVERRHLVLTHRPG-WPD-VQ-YLPSLEEAL--
-------ARQKTLFVIGGASVYAQCAR-L-LDTLYLSLIPGEHT-DTYLPDLG--CWNIVAEE--G----F-H--FDWSQLGAQKT-
>tr|Q7NHQ9|Q7NHQ9_GLOVI Dihydrofolate reductase OS=Gloeobacter violaceus (strain PCC 7421) GN=glr2476 PE=3 SV=1
----LIAVVAMDSRRLIGRGDGLPW-H-PEDLSAFKALTW-----G--QPLLMGRRTFESILARGKPLPEREHYVLTARRG-FPT-VR-YICSPDQAL--
--------PVERLFVIGGASVYAQTAD-Q-LDTLYLSLIPGLHT-DVFLPDLG--RWAVEIIE--K----F-G--FDWSQLVEGG--
>tr|A0A0R1H6W5|A0A0R1H6W5_9LACO DfrA protein OS=Lactobacillus amylotrophicus DSM 20534 GN=FC62_GL000238 PE=4 SV=1
----IAFIWAENSLGYIGKDGVIPWN-LPDDMQFFKEQTK-----G--HPVVMGRRTFDSLH--VKPLPERENIVLTRNPDWYA-GVT-VVHSVAQLLEQ
---I---AEDETIFVIGGAQIYEALVG-E-VDLLYITKVQNTIAGDTKMPQI---KFELIKEL--A----G-I--YPHHFYIYQRN-
>tr|L8H6D9|L8H6D9_ACACA Dihydrofolate reductase OS=Acanthamoeba castellanii str. Neff GN=ACA1_282280 PE=4 SV=1
----VSVIAAVAENGVIGR-GALPW-R-PEDFRFYLGKV-R----D--QIIILGRHCFYEA-----DHPAALTIALSRNPQ-QPSRCM-VARSLPEALQD
FRFS---STDKEILVCGGAKVFEEAMP-I-ATRLYLTRVHAEVEGDTFFPSDWR-HF--LVSE-RP----S-N--YHYTF-CIFEK-
>tr|U1P638|U1P638_9EURY Dihydrofolate reductase OS=halophilic archaeon J07HB67 GN=J07HB67_01219 PE=3 SV=1
----VVLIVAVDPAGVIGADGGIPW-D-PADMAHFERTTT-----G--NPVVFGRRTYESVAAVGGPLPDRTNVVLSRGQPDVAERVV-DSV--PAAL-D
D--A---GVDDRIFVAGGATVYEQCLPA--ADTMLRSEVHDRY-GDTHFPAW---RWAETDRE--E------H--EGFDVVTYRSE-
>tr|G2MKB1|G2MKB1_9ARCH Dihydrofolate reductase region OS=halophilic archaeon DL31 GN=Halar_0943 PE=4 SV=1
----LVAIAAVAENCVIAADGGIPW-DYPADKQFYNETIR-----G--HPAIMGRNTFGG-----DPKEGATNIVLT-RSV-VGEGAV-TAHSVEEAVAE
---A---TGAEVAYVIGGQGVYESFLD-R-LERIVITRIPGSY-GDRYFPELDD-EWKHDDEQ--V----I------LRVVEYVRR-
>tr|M5RM94|M5RM94_9PLAN Dihydrofolate reductase OS=Rhodopirellula maiorica SM1 GN=RMSM_02803 PE=3 SV=1
----VIALVAMTPTGVIGKDGDMPW-R-RSDLMRFKQLTM-----G--GTLIMGRRTYDSI---GRPLPGRRTIVVTRNAD-C-EGVC-RAENPEQAIRH
A-PA---SPNRGIYVVGGAEIYRQLLPC--CDEVWLTQVWSSV-GDTTLSI----KFRQIEQT--R----I-S--VPTEFIRMVHE-
>tr|F0ZSE1|F0ZSE1_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_88906 PE=4 SV=1
----ISIIVAVSKNFVIGSNGELPWH-LPKDLKHFKETTH-----G--FPCIIGRLTLEAFGD-----PNRFNIIVSKKEEFMNLSYV-VVPT--DGIDN
--------KTDLVYIVGGKGIYETSQPY--THELIITDIDTHIDDTDVVYNPFP-KWIQVSQH--H----H-N---FDFSITYYKK-
>tr|Q54LA0|Q54LA0_DICDI Dihydrofolate reductase OS=Dictyostelium discoideum GN=DDB0230113 PE=4 SV=1
----VSIIVAVSKNNVIG--GDIPWE-LPKDLKHFRDTTH-----G--FPCIIGRISLEAFGD-----PNRFNIIVSSKKEFINIQYV-IVKS--EAVKD
--------KTDLVYICGGKGIYEDSQQY--SHELIITDVDVHIEENDVIYNPFP-KWKVVNQI--H----H-N---LDFSITYYVK-
>tr|G9B1Z5|G9B1Z5_9CAUD Gp244 OS=Bacillus phage W.Ph. PE=4 SV=1
----ISSIVARDRNGAIGR-NELLF-K-SEDMKWFKQNTM-----G--KVVVMGARTHESI-G--IFLKGRINVVLTRNRE-VPL----VFHNIHE---N
Y--F---KDEKEIMIIGGGQIYEQFAP-M-VNRHYITEIKHAFKADTFYPPF---VYKEFYPA--F----G-D--IEFEFKVYKKV-
>tr|A0A059X2V3|A0A059X2V3_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=4 SV=1
----IAMVVATDKNRVIGRENKIPW-R-KDDLVLLRNLTQ-----N--HAVILGRKTYDSMLWSGKPMPGKMYVIVTRDAA-PVRNAV-VAHSIEEALR-
-------FDE-QIFVNGGASIYEALLPY--AERIYLTEVQAQA-GDVYFPSL---AWQEVSRE--H----H-E--YDFDVVVLDKI-
>tr|A0A059WRR2|A0A059WRR2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----IATVAAIDRNRAIGKADRIPW-R-QRDLRMLKQLTE-----G--PVVILGRKTYDSMVWSDRPMPGKMYLIVTRDVE-PTRNAR-TATSPEDALH-
-------LGD-DAFVIGGEHIFEAFLPY--TDRVYLTEVDTEV-GDAYFPTL---EWYEVSRE--H----F-E--HASDVVILQRS-
>tr|A0A059XB95|A0A059XB95_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----IAIVVAMDKNRAIGAENKIPW-RIKSDLIRLSRLTR-----G--NVVILGRKSFDSMVWSGKRMPGAQYIVVTRNSA-P-ANAQ-VAHSVQGAIQS
---L----GST-ICVIGGGSIFDATL--PYADVIYLTEVQTSIDVDAYFPELDP--WREVSRE--H----H-Q--YDTEEIVLERV-
>tr|A0A0E9G2V3|A0A0E9G2V3_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_2 PE=3 SV=1
----LAMIWAQ-KGGAIGKDGKLPW-HVPEDMALFKRMTM-----G---AVIMGRKTWESLDPRFRPLPGRRNFVVTRDP----DGAH-IARSLEEAYVE
---A----THDLVWLIGGGQLFARAIANEL-DGAVVTDFNK---GAAFAPGVPFS-WEA-QS--NP----------NYRCTIYRRP-
>tr|S2VP91|S2VP91_9ACTO Uncharacterized protein OS=Actinotignum schaalii FB123-CNA-2 GN=HMPREF9237_00013 PE=4 SV=1
----LIAIWAEAHDHALAK-LRLPW-N-PEDSAFFRAAV-R----G--RPVMMGRKTWISAGRR--PMPHSPTIVVSQQDF---V------AQLATHLFA
LARA---TGADAAWVCGGAGIYAETRE-C-SHILIRTVIDADVDADIFAPAIGP---GW-RLR-SP----G-G--LRYRYEAWARP-
>tr|K9F240|K9F240_9ACTO Uncharacterized protein OS=Actinobaculum massiliense ACS-171-V-Col2 GN=HMPREF9233_00337 PE=4 SV=1
----IGMIWAQSPSGAIANGTHLPWD-IPEDRKFFRTTVR-----G--RPLIMGRRTWEASGR---AMKNTPTFVVTRNGS---YAAR-QVGSVH--IFN
-------AAPDLAWIAGGGNIYAELEPV--ADILVRTTVDKNASNADVFAPE---TWEMRRTL--T----D-SSGERFRIELLARP-
>tr|A0A059WU99|A0A059WU99_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----ISLIAAIGANRAIGKDNRLLW-D-PQDRRRFWVLTK-----E--RPVIMGRKTWESKLADGKPFGGRTNIVVTSQES-YPGA-V-VCKTVEEALLK
--------INQYPYVIGGENIYLDALRH--AEQIHLTLVDDAPDAHAFFPYF---FEEDAREE--D----A-A--VSYRWAVFKRR-
>tr|A0A031GQD3|A0A031GQD3_MICLU Dihydrofolate reductase OS=Micrococcus luteus GN=folA PE=3 SV=1
----IAMIWAQ-PERVIGRDGTMPW-HVPEDLAHFRAHTH-----G---PVIMGRRTWESFPARFRPLPGRTNIVVSRTLTATEEGAV-VVPNFGAALAE
---A---DGCDTVWVIGGATLYEQAL--DV-SRAEVTVIDD---GDTHAPPL-DARWRR-AV--DP----------RHRFERWERD-
>tr|A0A0B2AJ35|A0A0B2AJ35_9MICC Dihydrofolate reductase OS=Sinomonas sp. MUSC 117 GN=LK10_14490 PE=3 SV=1
----VGLVWAQ-RDGVIGRNGTMPW-HVPEDLAHFSSLTK-----G---PVVMGRRTWESIPPKFRPFAGRTNIVVTRQK----GGAV-VVHSLGDGLAA
---A---PGGARTWLIGGGELFEQALALDG-DTAVVTFLDD---G-TKAPALGPE-WRP-GA--DP----------RYRIIVFRR--
>tr|N1UX83|N1UX83_9MICC Dihydrofolate reductase OS=Arthrobacter crystallopoietes BAB-32 GN=D477_013696 PE=3 SV=1
----VGLLWAE-SNGVIGRDGDLPW-HLPEDLAHFKRTTN-----G---PVVMGRKTWESFPEKYRPLPGRTNIVISRRP----EGAV-GAESLEQAMRT
---S---AGSDEIWIIGGGEIFRDAT--AL-DTAVVTVIDE---GDTYAPQL-GPEWTA-QR--EP----------RYRIERWTKG-
>tr|A0A0D1PST9|A0A0D1PST9_9RHIZ Dihydrofolate reductase OS=Mesorhizobium sp. UASWS1009 GN=QV13_16450 PE=3 SV=1
----IGLVWAQSLDGVIGLDGDMPW-HVPEDLKHFKEVTM-----G--EVLVMGRKTWSSFPESFRPLPGRTSIVVSTLTE--DPDKL-DHGDVHVVAQG
L-QL---KTGPMIWVIGGGSLYDQTLE----TVVERSLFNIH--GDTYAPKL--TSWTLTQQD-PS----A----VQYRFERWERT-
>tr|D2NRG7|D2NRG7_ROTMD Dihydrofolate reductase OS=Rothia mucilaginosa (strain DY-18) GN=RMDY18_04110 PE=4 SV=1
----LGAIWAQTDAGIIGRAGDMPW-YAPEDLAHFKKVTL-----G--APVIMGRRTWESFPPRFRPLPGRTNIVISSVTE--AEGAL-WVPSLDAALRD
A-VG---APAVDAWIIGGGSVYAEALSRNLPKTVERTLFYCQ--GDTRAPELTGGCWHV----VSE----T-P--MYFSFQRLERL-
>tr|I0UUG3|I0UUG3_9MICC Dihydrofolate reductase OS=Rothia aeria F0474 GN=folA PE=4 SV=1
----LGAIWAQTDAGIIGRDGTMPW-RAPEDLAHFKTVTM-----G--KPVIMGRRTWESFPPRFRPLPERTNIVISSVTG--GSGAL-WVPSLDAALGN
T-PL---HQRVTAWIIGGGSVYAKALSRDLPEIIERTFFYCQ--GDTYAPELAAARWRI----LGE----S-P--MYYSFQTLARL-
>tr|C7R3F1|C7R3F1_JONDD Dihydrofolate reductase OS=Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) GN=Jden_1031 PE=3 SV=1
----LSLIWAQSLNGVIGRSGTIPW-H-PTDLAHFQKTTR-----G--GVVIMGRHTWESLP--VTPLPQRVNIVLTSDRD-APG----VVTTPQQALHW
Y--T---VGHQAIWVIGGRQVYDTFMDY--ATQLIVTTV--GTVGDTEAPRI---HFVPQEPH---------D--YEVTVTTWLRT-
>tr|A0A059IUT7|A0A059IUT7_9RHOB Dihydrofolate reductase OS=Defluviimonas sp. 20V17 GN=U879_00760 PE=3 SV=1
----ITLVVARARDGAIGRRKEIPWH-SPEDLRLFQKETV-----G--GAVIMGRNTWESLP--SRPLPRRTNCVISDSSV--A--DH-VFQNVDDAIHG
-------AGHQRLYGIGGQSIYEALLP-R-ADRLLITEVSVDVPADTWFPTFD-SMWRENRRT--V----I----PRCTVRELLRV-
>tr|R0JKG6|R0JKG6_CORCT Dihydrofolate reductase OS=Corynebacterium crenatum MT GN=J433_13872 PE=4 SV=1
----IGAIWAQGRDGIIGDGTDMPW-HIPEDLKHFKKTTM-----G--QPVIMGRRTWESLP--FKPLPGRENFILSSREP-WSAGGT-VVTEIP-----
----------KSGWIMGGGEVYKATVG-S-ADVLEITLIDATFDTPVYAPEIP--NFNLDDES--E----W----YRYKFQRYIKV-
>tr|C2GIH4|C2GIH4_9CORY Dihydrofolate reductase OS=Corynebacterium glucuronolyticum ATCC 51866 GN=folA PE=4 SV=1
----MKAIWAQSRDGIIGDGSTMPW-HLPEDLHHFKNTTM-----G--EDILMGRKTWESIG--SKALPGRTNLVLSTREP-WSAGAT-VVSSVPA----
---------DFDGWLIGGGSLYQSLYP-R-LSRIAVTLVDVLLDTPVTVPSVTS-AFSHTVDG--I----W-P--VHYAFHEYTRK-
>tr|A0A0F9QPQ6|A0A0F9QPQ6_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_0747790 PE=4 SV=1
----LSAVFAIAEDMTIGD-GGIPW-F-PADMSSFRDRT-V----G--HIVVMGRKTWDSLPKK--PLDDRHNLVLTRAEG-NPD-------DP-EMLLS
---V---NEELIPYVIGGGEILNVFWN-D-IAYVYVTRIKGSPDGDTKFDLLTR-SW--EHSH-AS----D-VMSAAWMT-AWTRR-
>tr|A0A0N9HLI8|A0A0N9HLI8_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----HEMIVAYGRNREIGSHNHLPW-AMSADMRRFRNLTE-----G--KALIMGRKTFESLD---HPLTSHDNIVVTSHRL-DI-GV--SAVGTLAAALA
---D---RKHRQAIVIGGQMMYCAALS-Q-TDTLYATEIAADFPCDAYFPALPA-EWSEREHF--P----A-H--P-MDFVTYQRS-
>tr|A0A0M8PP02|A0A0M8PP02_9BACI Uncharacterized protein OS=Bacillus decisifrondis GN=AN161_23625 PE=4 SV=1
----INIIAAINKTNSIGKNGHLLHR-IKKDMDRFRKLTT-----G--NICLMGKNTFLELDK---SLDKRINVVLTSNKKFKAPDVI-VES---VLNHS
--------QDKDLWICGGEKLFEQALPF--SDKVYITYIHDNKKGDRYFPY----QFKIIHKE--E----H-----KFEFIDYVRK-
>sp|P0ABQ8|DYR8_SHISO Dihydrofolate reductase type 8 OS=Shigella sonnei GN=dhfrVIII PE=3 SV=1
----LHAILAA-ANGCIGKDNALPWP---GDLARFKKLTM-----G--KVVIMGRKTYESLP-----VKGRTCIVMTRQAL--ELGAI-FVNNVSDAMQE
---E----SGDVAYVIGGAEIFKRLM----ITQIELTFVKRLYEGDTYVDLAE-KDYEQNGME--E----H-D--LHTYF-TYRKK-
>tr|A0A059X6D9|A0A059X6D9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----FVMIVAASENGVIGDNNDLPW-KLPRDMARFKRITQ-----KI-GTVLMGRKTAESLP---KALPKRRNLVLSRSGY-D--GFE-TFSSLEAV-AQ
---A---VGNSVVAVIGGGEIYSLCAP-Y-ATQAYLTRVGAVCL-DTYLDVDAF-DYTLGLEQ--H----P-A--FPMTFMTLQNN-
>tr|A0A0G1FKU1|A0A0G1FKU1_9BACT Thymidylate synthase OS=Parcubacteria bacterium GW2011_GWE1_43_8 GN=UW06_C0003G0017 PE=3 SV=1
----FSIIAAVDSKRGIGIKGGLPW-RLKGDMEHFREITVGQ--GN--NGVIMGRTTWLSLPEKFRPLPERVNVVLTEQ-D-LPQGVL-RASSIDEAIEA
-------KSVSDIFVIGGGQVYTQVHP-L-CQKLYVTEIMQEF-CDTFFPEIP--EFVKTSES---------D--IAYHFVVYEKK-
>tr|A0A059X3W4|A0A059X3W4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
----LNMAAVGAQDRVIGR-NQLPWSQLVPDLQRFKRLT-M----G--CVLLVGRNTWFSFPPKMRPLPGRITFIVSTTLT-ADV-VL-ICPTLDDAITS
---L---YPKLEGFIIGGQRMYEEGMA-Y-ADRLEITEVGEKPPGNVFFPDYSA-SK--EETV-ET----Y-E--LKYR---TLER-
>tr|A0A059X717|A0A059X717_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----FSIVVAVDANFGIGRGGLLPW-HLPGDMKHFKEVTLEGSAHR--NVVIMGRKTWDSIPDKFRPLPGRRNIVLTRDIT-FPSGVE-RAFDFEDALAQ
-------SVPSKIFVIGGGEIFKIGHP-S-CQRLFLTHIETTF-CDRFFPSLP--SFKPIFKS---------K--TKYFFCTYERC-
>tr|K2CJT4|K2CJT4_9BACT Bifunctional dihydrofolate reductase-thymidylate synthase 2 / DHFR-TS (ISS) OS=uncultured bacterium (gcode 4) GN=ACD_28C00163G0
----FSIVVAMDEARGIGKDGVLPW-H-PSDLKHFAHITKTTSNAV--NAVIMGRKTWGSLPE-FRPLPGRLNIVLSRQQN-LPRGVL-LADSLDEAIK-
-------ANAEQLFVIGGGRVFEEALHDPHCEKLYITRIKGDF-CDTFLPRW---TFEKIEES---------G--IDFQFQTYRRK-
>tr|A0A0F7ZN01|A0A0F7ZN01_9HYPO Uncharacterized protein OS=Hirsutella minnesotensis 3608 GN=HIM_07653 PE=3 SV=1
----LTLIVA-R-NMGIGA-GTMPW---TKEMQYFSRVTTRLPPQ-A-PAVIMGRKTWDTIPN-FRPLKDRLNIVISRSSPP--AEP-LRV--LEHALRA
R-HA---GAIARVFVMGGAQIYAAALA---A--ILLTRIE--F-CDTFFP-L--DAWV-RRTP--------E---TPYEFEMWERQ-
>tr|A0A0D2A6D5|A0A0D2A6D5_9PEZI Uncharacterized protein OS=Verruconis gallopava GN=PV09_06618 PE=3 SV=1
----LTLIVA-K-NLGIGR-GTLPW---RAEMQYFARVTTRLPTLRG-PAVVMGRKTWDSIPK-FRPLKDRLNIVLSSR-----FGA-LWL--WEDVLQT
L-RA---PPVARVFVIGGANVYRSALE-GIA--VLLTRIH--F-CDTFFP-L--LGWH-RKSN--------E---TEFEYCLYERS-
>tr|S8A5C1|S8A5C1_DACHA Uncharacterized protein OS=Dactylellina haptotyla (strain CBS 200.50) GN=H072_8029 PE=4 SV=1
----ITLVVT-PPTLAIGK-NNMPW-P--SEMSYFARVTRRVPPP-PSPAVIMGRKTWESLPP-YRPLPGRINVVVSRD-----G-GEFWV--IEEGVKQ
KFSK---LELHQIFIIGGSQIYKLAMEEAYP--ILHTTIL--Y-VDVVFPPI--EQWK-RGDV--D-----N---VQFEFGLWERV-
>tr|W7HX75|W7HX75_9PEZI Uncharacterized protein OS=Drechslerella stenobrocha 248 GN=DRE_06766 PE=4 SV=1
----ISLVVT-PMVRAIGW-VQQHM-A--LRNGLFRSRPRRVPAP-PPQAVIMGRKTWESLPP-YRPLPGRINVIVSRS-----G-GEFWG--AEAGTRR
---G---LALHQIFIIGGSQIYGAAMAPAYP--ILLTTIL--Y-VDILFPSI--AEWQ-ECPL--T-----A---VQFEFGMWERT-
>tr|A0A0B0DNU9|A0A0B0DNU9_NEUCS Uncharacterized protein OS=Neurospora crassa GN=GE21DRAFT_4332 PE=3 SV=1
----LTLVLA-R-DMGIGL-GGLPW---TKEMAYFARVTKRLPSQ-LAGAVIMGRKTWESIPP-FRPLKGRLNIVISRSS----SGP-VMA--LEQAIHH
CQQQ---QKVGKVFVIGGGQIYGAALK-V-S--ILLTRVL--F-CDTFFP-LA-EEWV-RKSK--------V---TEYEFQMWERR-
>tr|L7IME1|L7IME1_MAGOY Viral dihydrofolate reductase OS=Magnaporthe oryzae (strain Y34) GN=OOU_Y34scaffold00087g1 PE=3 SV=1
----LTLVLA-R-DMGIGR-GTLPW---TKEMAYFARVTKRLPLSAKKPAVIMGRKTWDSIPP-FRPLKGRLNVVLSRSSAATTTVP-IHA--LPEALGQ
---L---QAVGKVFIIGGAQIYDVALD---T--VLFTSVM--F-CDASVA-L--TGWR-RTSK--------E---TQYEFQMWERS-
>tr|G1X446|G1X446_ARTOA Uncharacterized protein OS=Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) GN=AOL_s00043g470 PE=4 SV=1
----VIAIVS-PPTLAIGR-NDMPW-P--SEMSYFSRVTRRVPVP-TSPAVIMGRKTWDSLPP-HRPLPGRINVVVSRT-----T-DEIWV--IEEGVKQ
KFVP---VALDKIFIIGGAEIYKLAMEDAYL--ILHSTIL--Y-VDVFFPAI--NQWT-KGSV--D-----E---VKFEFGIWERN-
>tr|J3NK87|J3NK87_GAGT3 Dihydrofolate reductase OS=Gaeumannomyces graminis var. tritici (strain R3-111a-1) GN=GGTG_01668 PE=3 SV=1
----LTLIVA-R-TMGIGL-GALPW---TREMAYFARVTKRA-PP-GA-AVVMGRRTWDSIPP-FRPLKGRLNVVLSRAD----GPV-VHA--LPEALAR
Q--R---PPLGRVFVIGGAQIYDAALAAATV--VLLTSIL--F-CDTTLSSLG-GEWR-RAPK--------E---TSYEFQMWERE-
>tr|A0A0C4E363|A0A0C4E363_MAGP6 Dihydrofolate reductase OS=Magnaporthiopsis poae (strain ATCC 64411 / 73-15) GN=MAPG_06855 PE=3 SV=1
----LTLIVA-R-TMGIGR-GTLPW---TREMAYFARVTKRA-PP-TSPAVVMGRKTWDSIPP-FRPLRGRLNVVLSRS-----GPV-VHA--LPEALAR
RREQ---PPLARVFVMGGAQIYDAALAVGTV--VLLTSVL--F-LGEDDG--E-GPWR-RASK--------E---TSYEFQMWERE-
>tr|A0A0G2GIG9|A0A0G2GIG9_9PEZI Putative dihydrofolate reductase OS=Diplodia seriata GN=UCDDS831_g03059 PE=3 SV=1
----LTLIVA-P-SLGIGK-GTLPW---PKEMGYFARVTKRVVSTTITSAVVMGRKTWESIPP-FRPLRDRVNVVVSRDTAI--PAP-IAA--LPDALEK
L-GL---GALGRVFVIGGAQLYEAALK---A--VLLTRVW--Y-CDTVFP-V--SGWV-RREN--G-----K---VEFEFCLFERA-
>tr|K2R909|K2R909_MACPH Uncharacterized protein OS=Macrophomina phaseolina (strain MS6) GN=MPH_11915 PE=3 SV=1
----LTLIVA-P-SLGIGK-GTLPW---PKEMAYFARVTKRVPSI-ATAAVIMGRKTWESIPP-FRPLKDRINIIVSRDEGI--ATP-VAA--LEEAVEK
L-RG---GGLGRVYVIGGAQLYGAALR---A--VLLTRVW--Y-CDTVFP-V--EGWV-RKSN--------R---VEFEFCLFERL-
>sp|Q98Q32|DYR_MYCPU Dihydrofolate reductase OS=Mycoplasma pulmonis (strain UAB CTIP) GN=folA PE=3 SV=1
---MIISIWAMTKEGLIGKDNQMPWH-IKEEFQHFRRQTLH-------KTLIMGKNTFFSLP---KVFDKRKMYVLSHEKDFKHPDVEVIY-DYKDLLKE
YA----NNDKKDIYVAGGLYVYQQLIPL--SDILIVSIVKGSYEGNKYLS-VDFSNFVQYKIYD------------QFSVYYYKKK-
>tr|Q6KIQ5|Q6KIQ5_MYCMO Dihydrofolate reductase OS=Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) GN=dhfR PE=3 SV=1
---MIKLIVAIDPNNLIGSGTQMPWH-IKEEFKHFKETTLN-------HALLFGQNTFTNLP---SKLANRISYVFGFTKTPS-FSITSEQ-ELQNLFDK
FR----NSE-EILFISGGKYIYETYFHE--AEELIVSELKNIQNGDVYLN-WDLSNYKKTLEFE------------EFNVYSYKKK-
>tr|E4PYV0|E4PYV0_MYCHH Dihydrofolate reductase OS=Mycoplasma hyorhinis (strain HUB-1) GN=MHR_0684 PE=3 SV=1
---MIISIWAMTEDGLIGKDNSMPWH-IKEEFAHFRQTTLD-------KTLLMGKNTFLSLP---KIFDRRKMYVISDDPEFKHPEVHIIN-DYSWLIKE
YQ----RNPDKDLYITGGLIIYTALIPE--SDILIVSFIKGKYVGNRYLK-NINWDLFDLVDKG------------SFVVKTFKKK-
>tr|A0A0C2ELX4|A0A0C2ELX4_9MOLU Dihydrofolate reductase OS=Spiroplasma poulsonii GN=dfrA PE=3 SV=1
---MIKLLWAMDENNLIGKNNHLPWH-LKEELQHFKRTTVG-------QTILLGRLTYEGIG---GPLPNRKTLVLTTNQNYVHPDVKVVT-NLNDIINI
YQ----YNPTDDIYICGGKKIYEATLPY--ADELIISYIKVKYEGDTYFSTFDLAQFILIKESE------------QFVIKYYKRK-
>tr|F9QE42|F9QE42_9MOLU Dihydrofolate reductase OS=Mycoplasma anatis 1340 GN=GIG_03352 PE=3 SV=1
---MIKLIVALDKNNLIGKGNQMPWH-IKEEFQHFKRTTIG-------HSLLFGKNTFLGLL---KKLNGRKNIVLSENDIEN-LTIHNEE-ELIELFNR
FK----NSD-EVLFIAGGKTIYEKYFDW--ADELIISRIHNEYDGNVYLN-LDLSNYYLDKSHE------------FFDVEIYKKI-
>tr|W6AHD6|W6AHD6_9MOLU Dihydrofolate reductase OS=Spiroplasma culicicola AES-1 GN=dfrA PE=3 SV=1
---MITLLWAQTNEGVIGQNEKLPWN-IKEEMQHFIKYTKN-------KTVLMGRKTWDSLYV--KPLPNRQNIVITNQ----HKDIKFTN-KLENVLKD
FK----NS-QEELIIIGGKQIFELTLEY--ANKLVVSYIKEDYKGDVYAPFVDLNLWKVTQEFD------------EFIVRIYERY-
>tr|S5M0D5|S5M0D5_9MOLU Dihydrofolate reductase OS=Spiroplasma diminutum CUAS-1 GN=dfrA PE=3 SV=1
---MISFLWAQTESGIIGKDNQLPWN-IKEEMQHFINYTKG-------KTVLMGRNTWESLSV--KPLPNRKNILITSR----YNNLEISK-NLKEILEK
YK----ST-NEELVVIGGSQIYSTAFDY--ADKLVISVIKEEYQGDKYAPKWDKNDFNLTKNYK------------EFTVYYYERY-
>tr|A0A0K1P5E7|A0A0K1P5E7_9MOLU Dihydrofolate reductase OS=Spiroplasma turonicum GN=dfrA PE=3 SV=1
---MISLIWAQTRDNIIGKDNNLPWN-IKEEMKHFVNYTRG-------KTVLMGRNTFESLKI--KPLPNRKNIVITSR----YNDIVVCN-NLKTVFEN
YK----NK-DEELVVIGGAKVYTEAIKY--ADKLVISVIKDNYDGDVYFPNWNKDDFILKEDME------------KFVIYIYERK-
>tr|S5LUG7|S5LUG7_9MOLU Dihydrofolate reductase OS=Spiroplasma taiwanense CT-1 GN=dfrA PE=3 SV=1
---MVILIWAQTKKGVIGLNNKLPWN-IKEEMQHFINSTKN-------KTILMGRNTWESLTI--KPLPNRQNILITSR----YNNVEIST-DLDLILEK
YR----NS-QEDLYVIGGLQIYLTALKF--ADKLIISEIKKEYNGDTFAPKWDKKQYRLESEFE------------EFIVYVYERN-
>tr|A0A0M4JT41|A0A0M4JT41_9MOLU Dihydrofolate reductase OS=Spiroplasma cantharicola GN=dfrA PE=3 SV=1
---MISLIWAQSKNNIIGKDNKLPWN-IKEEMQHFINYTKN-------KTILMGRNTWDSLSK--KPLPNRKNILITSR----YNNLEVSN-NLEEILKK
YQ----LS-QEELVIIGGSQIYKSALNY--ADKLVISIIKQNYPGDVFAPQWDNLLFKMTHDFS------------EFTTYYYERQ-
>tr|V5RJD1|V5RJD1_SPIAP Dihydrofolate reductase OS=Spiroplasma apis B31 GN=dfrA PE=3 SV=1
---MITLIWAQDEKGVIGLNNRLPWN-IKSEMQFFVNYTKN-------KKVLMGRNTWESLRL--KPLPNRTNYVVTSR----HPDLIIIN-DFENFLNS
YK----NS-SEELIIIGGKQIYDFSLKF--ANKLVVSVVKGLYEGDTFAPQINDKEFTLTEYND------------EFEVKIYTRN-
>tr|W6AAW1|W6AAW1_9MOLU Dihydrofolate reductase OS=Spiroplasma sabaudiense Ar-1343 GN=dfrA PE=3 SV=1
---MIKLIWAQTKSGIIGKDNKLPWK-ISQEMAFFKAMTIN-------KAILMGRKTFEAIGS--KALPDRQNFVLSSQ----SDNLEWIK-DVNELIQK
YK----NNNKEDLMVIGGSQVYKLLFPF--ADELIVSIIKKDYDGDTKFPDLSFSDFRVYSEYD------------DFIVKKYERI-
>tr|D5E6F5|D5E6F5_MYCCM Dihydrofolate reductase OS=Mycoplasma crocodyli (strain ATCC 51981 / MP145) GN=folA PE=3 SV=1
---MIKLIVATDKNNLIGNVDKMPWR-IKEEFEHFRNTTIS-------HSLLFGRTTFLGLP---GKLDKRTIYVLSEQTLDN-ITIHNET-ELKNLFAK
FK----TNN-EVLFIAGGKSIYEKYFEY--ADELLISRVDGDYQGNVYLN-LNLSNYEVIKKFE------------KFVVETYKRI-
>tr|A0A0E3N8U2|A0A0E3N8U2_MYCSY Dihydrofolate reductase OS=Mycoplasma synoviae ATCC 25204 GN=VY93_02145 PE=3 SV=1
---MIKLIVALDPNNLIGKGDQMPWK-IAEEFKHFKTTTLT-------HSLLFGRNTFLGLP---AKLENRTIYVLSKERVPR-YTLKTEQ-ELFSLFAQ
FK----NDDFNTLFIAGGKTIYEKYYKF--ADELIISRVKKAYEGDVYLN-LDLSHYSLTKDYS------------EFAVEYYTKK-
>tr|D4XWL1|D4XWL1_9MOLU Dihydrofolate reductase OS=Mycoplasma alligatoris A21JP2 GN=folA PE=3 SV=1
---MIKLIVAIDKNNLIGNGDKMPWH-IKDEFIHFKKTTLN-------HALLFGRTTFLGLP---GKLEQRDNYVLSHEEIDQ-TVIHNEI-ELFELFEK
FK----NSE-KFLFISGGKSIYEKYYQF--ANELIISRIKGEFNGDVYLK-MDLSDYTLVKEFE------------KFNVEYYNKN-
>tr|E0TK88|E0TK88_MYCHH Bifunctional protein including dihydrofolate reductase and deoxycytidylate deaminase family domains OS=Mycoplasma hyorhinis (st
---MIISILAMGKNNLIGKGDDLPWY-VKEDFDFYREQTKH-------HDILVGKNTFFTLP---KSLQKSKIYIVSDDKNFNNENVKTIN-NFSNLIKE
YQ----NHPSKHLFVSGGYTLYKSIINE--CDQLIISFIKGEHSGDIFLN-ELKWEKFEEIDKG------------KFIVKKYKKT-
>sp|P78028|DYR_MYCPN Dihydrofolate reductase OS=Mycoplasma pneumoniae (strain ATCC 29342 / M129) GN=folA PE=3 SV=1
---MVKAIWAMDQNGLIGNGNSLPWR-IKAELQHFRQTTLH-------QDVLMGSATYLSLP----PFSERNVYILTRNLNFN-GCLTKVIHEYENFIQP
YL----HHPDKHLYICGGAQVYEQLIPR--CDALIVSTIFGKYTGDKYLKV-DFSPFELTKSFA------------EFKVAYYHKI-
>tr|W0GQG2|W0GQG2_9MOLU Dihydrofolate reductase OS=Spiroplasma mirum ATCC 29335 GN=P344_02580 PE=3 SV=1
---MIKLLWAMDQHGLIGKDNHLPWH-IKAELQHFKAETLN-------KTILLGRTTFEVIN---CVLPNRKTIVVTHNPNYHHPDVQVVH-DLQPILTQ
YQ----QNPDNELIVCGGSKVYEETLPV--ADQLIISYIKGKYTGDTYFPPFNLDDFELKFEYD------------EFTVKKYVRR-
>tr|R4U3I3|R4U3I3_9MOLU Dihydrofolate reductase OS=Spiroplasma syrphidicola EA-1 GN=dfrA PE=3 SV=1
---MIKLLWAMDENRLIGAGNKLPWH-LKEELAHFKATTLG-------KTILFGRKTYEGIG---KKLPDRKIFLLTHQEDYKDVDVEVIN-NFDNIIEK
YS----KNPTNEILICGGKKVYEDFLPY--ADMLIISEIKGHYVGDTYFPGFDITAFQQISVKP------------GFIIKEYIRK-
>tr|A0A0K2JIG6|A0A0K2JIG6_SPIKU Dihydrofolate reductase OS=Spiroplasma kunkelii CR2-3x GN=dfrA PE=3 SV=1
---MIKLLWAMDENNLIGQNNQLPWH-LREELQHFKETTLG-------QTILFGRLTYEGIR---RRLSKRKTLVLTRQLDYQHPDVEVVT-DLTAIINF
YH----QNPKENIYICGGKKIYEATLPY--ADELIISYIKGKYQGDTYFPSFDLNKFTLIKEYQ------------QFVIKYYKRK-
>sp|P47470|DYR_MYCGE Dihydrofolate reductase OS=Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) GN=folA PE=3 SV=1
---MLIAIWAMTQEGLIGNNNTLPWM-IKQELAHFKKTTLF-------QALLMGRKTYESLP---KVFEKRTIFLLSKDQNYRGSEVKVIN-DFWPLIKS
YQ----ANKEKDLFICGGKSVYEQTINE--CDQLIVSIIKKKYKGDQFLK-VDLSKFVLNEEFE------------EFNVNYYRKK-
>tr|M9WC93|M9WC93_9MOLU Dihydrofolate reductase OS=Mycoplasma putrefaciens Mput9231 GN=folA PE=4 SV=1
---MIKLIWAQTKTGVIGKNNQLAWS-IDQELQHFRKATWN-------KDIIMGRKTFASLNF--QPLKNRFNYILTSDPEKYYDNLIFIN-DVKPIIAK
YA----NNPDNELFVIGGKIIYEIFLDS--ADQIIRSIVKKDYQGDIYISELDLNKFQKISDFD------------EFYIERWVRK-
>tr|S6G7W5|S6G7W5_9MOLU Dihydrofolate reductase OS=Mycoplasma yeatsii 13926 GN=folA PE=3 SV=1
---MIKLIWAQTKNGVIGNNNSLPWD-IKEEMQHFRRTTTK-------KDLVMGRKTFASLNY--KPLKNRLNYVLTNNVDKYYDNLIIIN-SVDPIIEK
YA----KNQENEIFVIGGKIIYELFLDS--ADEIIRSIIKKDYQGDTFMRDLDVNKFDKISDYE------------EFYIERWVRK-
>tr|A0A084U4F8|A0A084U4F8_MYCIO Dihydrofolate reductase OS=Mycoplasma iowae DK-CPA GN=folA PE=3 SV=1
---MITLIWCEDKNGGIGLNNSIPWH-IKEDLEFFKATTLN-------HTIVMGRKTFESIG---KPLKNRKNIIITKNKEYKDQSVEIYN-NIQDVLRK
YK-------NEDIFVIGGKQIYFLFNKY--ADRLLVSKLFESYNCDTYMNDFDYSNFYLKKNKS------------EFKIYHYFKK-
>tr|B2DA24|B2DA24_UREUR Dihydrofolate reductase OS=Ureaplasma urealyticum serovar 5 str. ATCC 27817 GN=folA PE=4 SV=1
---MLKLIWCQTLNGGISKNNKLPWY-VKEELEHFYKTTKN-------HKIVMGKSTFDSLEQ--KPLSNRTNIIFSSI-MQTDQSYFVTN-DFQQLLND
AK-------KEDIFIIGGKELFDIFLNH--ADALIVSVLNDYYDCDLYMK-VDYNNFNLDKVYD------------NFVVNYYSSK-
>tr|B2D9J8|B2D9J8_UREPR Dihydrofolate reductase OS=Ureaplasma parvum serovar 6 str. ATCC 27818 GN=folA PE=4 SV=1
---MLKLIWCQTLNGGISKNNKLPWY-IKEELDHFYKTTKN-------RKIIMGKNTFDSLNQ--KPLNNRTNIIFSSI-MQTDESYFVTN-DFQQVLND
AK-------KEDIFIIGGKELFDIFLAY--ADVLIVSVLKDYYDCDLYMK-VDYNNFNLDKVYD------------NFIVNYYSNK-
>tr|Q03F97|Q03F97_PEDPA Dihydrofolate reductase OS=Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) GN=PEPE_1069 PE=3 SV=1
---MISMIWAEDLRHGIGKQQSIPWH-IPGDMAFFKKTTSG-------NTVVMGRKTFDSIG---KALPNRKNIVLSHHPTSLPDSVVGVG-SLSELQAI
FE----THPNEKFYIIGGSHLYNALLSQ--ADELLITRIQKDYQCEVLAPDITQNEFKLASEHESTE------RNPAYTFETWIRI-
>tr|A0A0R2KVA5|A0A0R2KVA5_9LACO Dihydrofolate reductase OS=Pediococcus stilesii GN=IV81_GL000533 PE=4 SV=1
------MIWAEDSKHGIGKSQTIPWK-IPDDMLFFKKTTTG-------NTVVMGRKTFNSIG---KPLPNRDNIVLTHHTDTLPNGIVGVS-SFEELEKI
TD----NHSENKYYVIGGAFLYNHLLKY--ADELLVTRVDGDYNCDVFAPAIPEKIFKLVSLVDKTE------AAPKHSFQVWRRI-
>tr|K9I9J4|K9I9J4_9LACO Dihydrofolate reductase OS=Pediococcus lolii NGRI 0510Q GN=PLO_0243 PE=3 SV=1
---MITMIWAEDDRHGIGRQQSIPWH-IPDDMAFFRQTTLD-------HSVIMGRKTFESIG---RPLPRRTNLVLTHHPEHLPSEVRGFS-SYEELLAS
L------TKTEKHFVIGGSAVYHKLMPV--ADELLITKVTGDFQCDVFAPVVDKQKFTLQEPGKSVP------GVPDHVFQQWVKR-
>tr|R7MG86|R7MG86_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:628 GN=BN740_00900 PE=4 SV=1
---KLTIIAAIGKNNELGKNNDLIWH-IKEDLNFFKAITEF-------NYIVMGRKTLESLP---KKLKNRKYIVISRTLKS-CEDYIVYN-SIDDFLNN
FT----PEKNRSVYIIGGASIYKEMLPF--TTNMLITHINSESECDEYFPEIPVSLFKGIEKYYDEK------NNLTYTRKFYIQK-
>tr|F2I4Y3|F2I4Y3_AERUA Dihydrofolate reductase OS=Aerococcus urinae (strain ACS-120-V-Col10a) GN=folA PE=3 SV=1
---MLIAIWAHAANGIIGKNNQLPWH-ISEDMKFFKQETLH-------KTVVMGRKTFESMGN--RPLKERKNYILTRKKSLPKDQVQIIN-QMDEIIEL
AK-------AEDVMVIGGAEIYRLFWPY--LDELRITNIAENVEGDTSFN-PDLSQFRRYADQDLNSK-----SKYHYQFEFWERK-
>tr|R6GUD3|R6GUD3_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:582 GN=BN721_00173 PE=3 SV=1
---NVSMIAAVGKNNELGKNNELIWR-IKEDLKFFKEYTMG-------KQMIMGYNTFYSLR---GPLPGRKHIVLTQNHESDNEQIYIVH-SMQELL-E
YI----ENFRQEFIVIGGASLYKNMLEY--AKTLVLTEIDAESKADVYFPRIDESKWNKETIYEGNE------NGIVYKRELYVRK-
>tr|A0A0E9F114|A0A0E9F114_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_6 PE=4 SV=1
---LYLIVAITEKSNAIGKDNNLLYF-LKEDMNFFKEKTCG-------NSIICGRKTFEGFKI--KPLPKRKNIVLTKS-DF-FDGVSVFK-SIEILIDF
VK----NNPNEKFFVCGGMSIYKQLIDF--CSKMYITKYEEEIVADSHFPKIDEEIWKVTENGESE--------NPKLAFYTYERI-
>tr|A8SNM7|A8SNM7_9FIRM Dihydrofolate reductase OS=Parvimonas micra ATCC 33270 GN=folA PE=4 SV=1
---LYLIVAITEKTNAIGKDNNLLYF-LKEDMNFFKEKTCD-------NSIICGRKTFEGFKI--KPLPKRKNIVLTKS-DF-FEGVRRFK-NIEDLINF
VK----ENPKEKFFVCGGMSIYEQLIDF--CSRMYITKYEEEAVADSHFPKIDEKVWKVVEDGKSE--------NPKLTFYTYERI-
>tr|F5TC99|F5TC99_9FIRM Dihydrofolate reductase OS=Parvimonas sp. oral taxon 110 str. F0139 GN=folA PE=4 SV=1
---LYLIVAITEKSNAIGKDNNLLYF-LKEDMNFFKEKTCG-------NSIICGRKTFEGFKI--KPLPKRKNIVLTNS-NF-FEGVKIFK-NIEDLIEF
VK----ENPKEKFFVCGGMSIYKQLIDF--CSRMYITKYEEEIIADSHFPKIDETIWKVTEKGESQ--------NPTLTFYTYERI-
>tr|B2YFY8|B2YFY8_MHVB Dihydrofolate reductase OS=Musca hytrovirus(isolate Musca domestica/United States/Boucias/-) GN=MdSGHV011 PE=4 SV=1
---RLILIAAIARNNIIGSTSSLPWH-IRDEMQFFKSIITNRWHLVGKIAYIMGRNTYNAMP----PITS--SIVVGRLHHPT---VDK---AIEHARH-
------HMQADTVFVLGGSRIYDECLRL--CHRLIISRIHNSYDGDIFMPPINTQKYRLETA--FS---------PHFNIEQWIRI-
>tr|E4KQ34|E4KQ34_9LACT Dihydrofolate reductase OS=Eremococcus coleocola ACS-139-V-Col8 GN=folA PE=3 SV=1
---MIYFVYAQDLQGGIGFQGNLPWH-LPNDLKFFKATTMG-------HTMLMGRKTFEAMDC--RLLPGRKTIVMTQQANYGIAGLQVLH-TVPEILAL
AE-------SEDIYIIGGAQIFDLFWDQ--VDVIYRTVIEATFTCDTHVKNLDPKLWRLVKVYEKSPT-----NPYRHRIEVWVRL-
>tr|K1MMJ9|K1MMJ9_9LACT Dihydrofolate reductase OS=Facklamia ignava CCUG 37419 GN=HMPREF9707_00543 PE=3 SV=1
---MIRFVYAQDENGGIGYQNELPWH-LPNDLKFFKETTMG-------HTLLMGRKTFESMNR--RLLPGRKTVVLTTNPNYCIEDLTVVT-SKEEALAL
AE-------ETDLMIVGGAGVFLSFFDE--VDEITRTVIHASFKHDVSMPQIDETQFELVKHVEADAE-----NPYPHTFEWWRRK-
>tr|C6JM97|C6JM97_FUSVA Uncharacterized protein OS=Fusobacterium varium ATCC 27725 GN=FVAG_02242 PE=4 SV=1
---KLNMIVCVAENNLIGKGNGLLWH-SLEELNYYKSKTVG-------NVVLFGENTAKYVPINLM-KKNREVIVLTLDSKLK------------DIMEQ
Y-----KDSGKDIFICGGYTIYKYYLDE--IDEIYISKLKPHVKNPLYFPDVEKYGYNLVSDYN------------DFTATIYKK--
>tr|C3WA87|C3WA87_FUSMR Uncharacterized protein OS=Fusobacterium mortiferum ATCC 9817 GN=FMAG_00336 PE=4 SV=1
---EINMIVCVAENNLIGKGNGLLWH-SKEELAYYKERTIG-------NVVIFGKNTAKYVPLELM-KKNRDVIVISSKDSFY------------EIVER
Y-----KDTDKKIFICGGATVYKAYLEP--LDNIYISKLKSHIENPLYFPNVEEFGYSVVEEYQ------------DFTAYTYKKK-
>tr|A0A017H5T6|A0A017H5T6_9FUSO Diadenosine tetraphosphatase OS=Fusobacterium necrophorum subsp. funduliforme B35 GN=C095_01430 PE=4 SV=1
---RLKMIVCVGENNLIGKGNGLLWH-SKEELLYYKSITIG-------QVTLFGENTAKFVPIDLM-RKTREVLVLTMDSNID------------EILKQ
Y-----P--EKDVFLCGGATIYQYYLEP--IAQIYLSKLKAHVANPLYFPNLEELGYEVVKEYE------------DFIAYIYEKK-
>tr|E5BIG2|E5BIG2_9FUSO Uncharacterized protein OS=Fusobacterium gonidiaformans 3-1-5R GN=FSBG_01782 PE=4 SV=1
---RLKMIVCVGENNLIGKGNGLLWH-SKEELLYYKSITTG-------QVTLFGENTAKFVPIHLM-KKTREVLILTMDSNIE------------DILQQ
Y-----P--EKDVFLCGGATIYRYYLEP--IAQVYVSKLKKHVENPLYFPNLESLGYVCVKEYE------------DFIACIYEKK-
>tr|D5RB07|D5RB07_FUSNC Uncharacterized protein OS=Fusobacterium nucleatum subsp. nucleatum ATCC 23726 GN=HMPREF0397_0392 PE=4 SV=1
---NLKMIVCVGKDNLIGRSNGMLWH-IKEELMYFKSKTVG-------NTVLFGGTTAKYVPIELM-KKNREVIILHRNMDVP------------KLIED
L-----TLENKTIFIAGGYSIYKYFLDE--IDEIFFSKIKDSVEEPLYLPNIEDYGYKMVDDYE------------EFTAYIYKIG-
>tr|D4CV55|D4CV55_9FUSO Uncharacterized protein OS=Fusobacterium periodonticum ATCC 33693 GN=FUSPEROL_01297 PE=4 SV=1
---NLKMIVCVGKDNLIGRSNGMLWH-IKEELMYFKERTMG-------NTVLFGGTTAKYVPVELM-RKNREVIVLHRTVDVP------------KLIED
L-----TQENKTIFVAGGYSIYKYFLDE--IDEIFLSTIKDSVEEPLYLPNVEEYGYKVVEEYD------------EFIAYVYKK--
>tr|I1A5R1|I1A5R1_9MOLU Dihydrofolate reductase OS=Mycoplasma canis UFG4 GN=MCANUFG4_02076 PE=4 SV=1
------MILASTISGLIGKDNTLPWY-IPKDLNFFSEQTKN-------SILIFGNNTFQNLPEKMFIKKNRKFYVLSIEKIRQDKEFNSIS-ELELFLTE
--N---NNKNKNIYLCGGKFIYETFFNH--ASELYLTTIKNNLD--KNFKDEEIKKFFKNKIYED----------FQIKIEKYSK--
>tr|A0A059WV75|A0A059WV75_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
---KLCIVAAIGENRELGKDNHLLWH-LAEDMRFFKEVTMR-------HYVIMGRKSFESIPAKYRPLPDRVNVIISRDPDYMVEECYTCT-SLEEGMRL
AE----ENGEQRAFLIGGGQIYKLAMDM--VDEMYITHVHGSFPAQVYFPEFDETQWRKTASMVADLQ-----NQFSFDIYLYEKL-
>tr|A0A074ZUC6|A0A074ZUC6_9TREM Uncharacterized protein OS=Opisthorchis viverrini GN=T265_02929 PE=4 SV=1
---YLPYLNETAEHYFEQLGNRTSWK-STEDMAFFKKLT-TEAKPGLKNVVIMGRNTWNSIPEKFRPLQDRINIVISSTLASAPPGVF-VLPNLTACM--
------SCDADRIFVIGGSQLYKDVLEY--PVRIFCTHVMKDVDCDTFFPEVNWDELKKI-EVPSEVIE---ENGYTYKFAVYDIP-
>tr|A0A094ZXU3|A0A094ZXU3_SCHHA Dihydrofolate reductase (Fragment) OS=Schistosoma haematobium GN=MS3_07609 PE=3 SV=1
---RLNVVVAVSENWGIGKGGGLPWK-IKKDMEFFKSIT-TKAHPGLKNAVVMGRFTWESIPESFKPLKDRINIVVSSTLSHAPPRVQ-IVPNLNAAI--
------SSIVDEVFIIGGHRLYEEALKY--PVRIYCTHILNEVDCDTYFPKLDWSKLKKV-DIPAGTFT---ENGFTYKFCVYDVP-
>tr|F7ETA7|F7ETA7_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=DHFR PE=4 SV=2
----KRFTNAIIIKYNVSKHGSCVSY-VRNEFRYFQKMTTTPTVKGKQNLVIMGKKTWFSIPEKSRPLKDRINIVLSRELKEPPQGAHYVAKSLDDAL--
------ASKVDMVWIIGGSSVYKEAME---HQRLFVTRILQDFESDTFFPEIDLEKYKLIPGVPADTQE---EKGIQYRFEVYEKH-
>tr|A0A084E9Q7|A0A084E9Q7_SPHYA Dihydrofolate reductase OS=Sphingobium yanoikuyae GN=CP98_04707 PE=3 SV=1
---NLTAIVAVNLQGVIGCGNALPWH-VRSDLKFFRETTTG-------GTVIMGRKTFDSIG---RPLPKRHNIVVSHNAALCLPNVQRVS-SVEEAIFA
A-----SRLNRETFLVGGASMYSQMAAY--VDRYLITLVHKDVHGDAYFDEKIIGDWNLSVEKGPVVE----GDDAAYEIWELNHP-
>tr|A0A059X2D3|A0A059X2D3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---SLTSIVAVNRDGVIGRQNGLPWR-LRSDMKFFREQTLD-------NVVIMGRKTFDSFG---RGLPRRYNIVISSHFGLFGSDCQTAT-GVEDALFR
ATL--APRIYKESFVIGGATIYEQFAPF--VDRYLITLVEKDVPGDTFFNQEPLGDWEIRPS-CPASE----ADEADFTTFEVLAR-
>tr|F6IFH3|F6IFH3_9SPHN Dihydrofolate reductase OS=Novosphingobium sp. PP1Y GN=PP1Y_AT690 PE=3 SV=1
---PLTAIVAIDRHGAIGCKNHLPWS-IKSDMAFFRKTTTG-------NIVVMGRKTHDSIG---GCLKGRENVILSRRAPLFTDSCRFVS-ELPEAIAA
IE----CCSAKEAFVIGGAYTYEEFYNL--VDRFLVTFVDHVAEADAFLSKSIIDEWRSEDEFPAVPG----QDQYGFRIKCFTAP-
>tr|U5Q2D8|U5Q2D8_9BACT Dihydrofolate reductase OS=Bacteroidales bacterium CF GN=dfrA PE=3 SV=1
---TISIIVAFADNRAIGRDNRLLWH-ITEDLRYFKGITGG-------HTIIMGRKTWESIG---RPLPNRRNIVVSRSLAESVPGVEFYP-SFEGAIPG
QT----DNSKEEIFVIGGGEIYRQAIPV--ATKIYATLVHTTIEADTFFPKINLSEWNEIHSF-QRGE----KFEYPFEFVVVERK-
>tr|A0A0R2X051|A0A0R2X051_9GAMM Uncharacterized protein OS=OM182 bacterium BACL3 MAG-120924-bin41 GN=ABS30_07665 PE=4 SV=1
---KLSLIVAMAENRTIGRDNTLPWH-LSEDLKYFRRTTTG-------HCIIMGRNTWESIG---RPLPNRRSIVVSSNPNYI-EGAEVVS-SLAAAKSI
SA----ELGVDEAFVIGGARLYADALQQ--AECFHLTRVQASVEGDTHLPEFDEDEWQEVAEFAAEGQGE-GENPYAYSICKLVRL-
>tr|A0A059WX27|A0A059WX27_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---RISIIAAVATNGVIGREGRLPWH-LSTDLKRFKQLTMG-------HAIIMGRRTWESIG---RPLPGRRTIVVTRQSEYSPEGVQVAA-SLDDALDA
AQ----AAGECDAFVVGGAELYHEALGL--ADRLYFTEVAADVEGDTYFPVFDTFEWESWVETEAHAAD--AENDYAFVFVTLERT-
>tr|I7IGH8|I7IGH8_BABMI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Babesia microti strain RI GN=BBM_II03680 PE=3 SV=1
---KVC-SI---PNGGIGNEGKLPWKTLPRDLKHLQDITTAYGDHSVQNVVIMGRKTYISIPKSSRPLKDRINIVLSSSVSDF--DGVIAAKSMQDAFDK
L--E--KMKFNKIFIIGGSSVYKEAYDL-IVEKVYVTRVNKELPADTFVTS-VPPIFE-----IVGISRTFSYNDIPFDFIIYM---
>tr|A0A061DYU4|A0A061DYU4_THECC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Theobroma cacao GN=TCM_006844 PE=3 SV=1
---TYQVVVAATKDMGIGKDGKLPWK-LPSDLKFFKDVTLTTSDSGKKNAVIMGRKTWESIPLQNRPLPGRLNVVLTRSGSFDIAENVVICGSMTSALEL
LAASPYCLSIEKVFVIGGGQIFRESLNAPGCDAIHITEIETSIECDTFMPSIDSSVFQ-----PWYSSFPVVENDIRYCFTTFV---
>tr|E3T5S3|E3T5S3_CROVB Putative bifunctional dihydrofolate reductase/thymidylate synthase OS=Cafeteria roenbergensis virus (strain BV-PW1) GN=crov502 
---KFKV--ATSRNHILGNNNLIPWSGYPTDVQFFKKLT-SFSFKNLENIVIMGRKTWESLPP--NKLPGRIPIIISNTLPFSDK---YLASNLDYALHL
A--T--KIPHNEIWVIGGKQVYTEALTH-KCDKIYHNIIPDEYEGDTSLEIISPII-------VKQL----IE--------------
>tr|L1JGV3|L1JGV3_GUITH Bifunctional dihydrofolate reductase-thymidylate synthase OS=Guillardia theta CCMP2712 GN=GUITHDRAFT_69716 PE=3 SV=1
------MIVACTKNGGIGRDGKLPWN-LKEDMAWFKKVTTEASADKPEGCNIMGRKTWESIPPSFRPLSGRVNIVLSRSPDS-MSDGVVLSKSLADAMQV
VDS---RDDISQCFVIGGGELYREAMNSDLCKVIFRTLVHGEFECDTFIPCEIPKGFI-----R-----DTEDKGIQYEFQIFV---
>tr|Q22KR8|Q22KR8_TETTS Bifunctional dihydrofolate reductase-thymidylate synthase OS=Tetrahymena thermophila (strain SB210) GN=TTHERM_00312120 PE=3 SV=
---HFDIVL---KKQGIGYKNSLPWR-LPNELKNFKKITTET-NKGLQNAVIMGKNTWEALPKKQQPLKDRLNIVISTTMQEGQ-DHSYACKSLDSALNF
LEQ---QNQIQDALVIGGAKLCQQALSD-RLRQIHLTRVGVEVECDVFMQKDYLKNFD-----MIEVSETQSENNLNYDFTRYF---
>sp|Q27828|DRTS_PARTE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Paramecium tetraurelia GN=GSPATT00019973001 PE=3 SV=1
---TFSMVL---LNGGIGYQNRLPWK-LKEDLQRFKKITTG-------GIVIMGRKTFESMN--SKPLPNRVNVVISKNMKSSN----QVFPRIEDALQF
YN-----TSHQKLYLIGGKRIFEEGLAT-KCSDVHLTRIGVETKCDVYLNKNIFSTFQ-----VNKTSQTKSENGINYDYQHLI---
>tr|D2TF54|D2TF54_9PHYC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Emiliania huxleyi virus 99B1 GN=EhV113 PE=3 SV=1
---KVCIVVCSDGRIAIGINNKIPWN-SKADMHNFRQLTTSTSMPICENVVIMGAKTWQSIG---KRLPNRYNIVISRNKDARRVNNVGISSSIELAISE
LK-T--VSDIETIYVIGGSYIYKDVIDL-IVDKIHMTFVSNQHDPGAFDNCDTFFPFT-----VNDLESNFIKSKTS-----YV---
>tr|Q9SIK4|Q9SIK4_ARATH Bifunctional dihydrofolate reductase-thymidylate synthase OS=Arabidopsis thaliana GN=At2g21550 PE=3 SV=1
---SYQVVIAATRDMGLGMDMKLPWD-LPSEYQFFQDVTTRTSDPTKRNATIMGRKSWESTPLEIRPLPGRLNIVLTKSSCHNIAENVLVSSSMESALEL
LATEPYSLSIEKVFVIGGGELLRNYMNASICDAIHLTEIDISVPCDAFAPRVDTSLYR-----PWYSSFPVVENGIRYSFNTYV---
>tr|M4C8Q3|M4C8Q3_BRARP Uncharacterized protein OS=Brassica rapa subsp. pekinensis GN=Bra000581 PE=4 SV=1
---SYQVVIAATRDMGIGIDMKLPWD-LPNEFQFFQDVTSRTSDPRKRNATIMGRKSWEATPLEFRPLPDRLNVVLTRSNCHSIPDNVMVCGSMESALEL
LAKPPYSFSIEKVFFIGGGELLRHYMNAPSCDAIHLTEVDITVPCDTFAPRVDTCLYH-----PWYSSLPVVENGIRYCFNTYV---
>tr|V4M1J1|V4M1J1_EUTSA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Eutrema salsugineum GN=EUTSA_v10000156mg PE=3 SV=1
---SYQVVIAATKDMGLGMNMKLPWD-LPREYQFFQDVTTKTSDPKKRNATIMGRKSWEATPLDIRPLPGRLNVVLTKSSCLSIAENVLVCNSMESALEL
LATEPYSSSIEKVFFIGGGELLRHYMNAPNCDAIHLTEIDISVPCDAFAPRVDTCLYR-----PWYSSFPVVENGIRYSFNTYV---
>tr|R0FWL1|R0FWL1_9BRAS Bifunctional dihydrofolate reductase-thymidylate synthase OS=Capsella rubella GN=CARUB_v10023109mg PE=3 SV=1
---SYQVVIAATRDMGLGMDMKLPWD-LPMEYEFFQGVTTKTSDPKKRNATIMGRKTWDSTPLEFRPLLGRLNVVLTSSSCLDIGDNVLVCSTMESALEL
LATAPYSLSIETVFVIGGGELLRNYMNAPDCEAIHLTEIDISVPCDAFAPRVDTSLYH-----PWYSSFPRMENGTRYSFNTYV---
>tr|A0A059BQ73|A0A059BQ73_EUCGR Uncharacterized protein OS=Eucalyptus grandis GN=EUGRSUZ_F01594 PE=4 SV=1
---SYQVVVAATRDMGIGKDGKLPWK-LPSDLQFFKELTSTTMDPRKKNAVLMGRKTWESIPLQFRPLPGRLNVVLTRSGRLETKEDVVLCGSRASALEL
LASSRYCSAIENVFVIGGGQLLREALNAPDCVAIHITEIEDHVDCDTFIPSIDLSVFR-----PWYASPPMVENDYRHSFVTYV---
>tr|L7RCT0|L7RCT0_9VIRU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Acanthamoeba polyphaga moumouvirus GN=Moumou_00308 PE=3 SV=1
---KFSIVVAVNNDIGTCEEYGIPWPYLRQDMNFFRKITTTTKEEYELNGIIIGHNTWKTLSDAYRKNKKRYNIVVTRDPEPEDIINTKFVNSFEEAVTY
AS-N--LDNVYKIFAIGGSTIYSAALKH-NLESIYLTHVKKSYPIN--VERYIYFPIN-----HDQLKDAINLNNIHLSFKKYN---
>tr|J3IZ98|J3IZ98_9VIRU Thymidylate synthase OS=Acanthamoeba polyphaga lentillevirus GN=R427 PE=3 SV=1
---KFNIIAAINNDIGVKETFSMPWPYLKDDMNHFRKITTDTGIESGVNAIIVGFNTWQTLPSSYRNIRSRFNIVISRDDETDGQ-FHKYVKTFDEAIEF
AS-S--LTNLNEIFVIGGGVIYDLALKH-LLDKLYLTHVGSNYPIDDNVEKVVHFPLT-----WSKIEKMCDSNNILLRFQEYS---
>tr|M1NN30|M1NN30_9VIRU Dihydrofolate reductase-thymidylate synthase OS=Moumouvirus goulette GN=glt_00631 PE=3 SV=1
---KFSIVVAVNDDIGTCEEYGIPWPYLRQDMNFFRKITTTTSKENQSNGIIIGHNTWKTLGNAYQKNIKRYNIVVTRDTEPNNLSNTKFVKSFSEALVF
AS-N--LDNIDKIYAIGGSIIYNEALKH-NLESIYLTHVKKNYPIT--VEKYIYFPIK-----HDQLKNAIDLNNIHMSFKKYN---
>tr|G5CSP8|G5CSP8_9VIRU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Megavirus chiliensis GN=mg380 PE=3 SV=1
---KFSIIVATNNDIGTQEECNMPWPYLKDDMNFFRKITTATSQSNEINACIIGHNTWKTLSDAYRKNMKRYNIVITRDSQPNDKQNIKYVPTFNEAIEY
AS-H--LENINNIFVIGGGVIYDLALRH-NLENIYLTHIQKNYTIE--SDRRIYFPLT-----HKQLNDAVEKNNIKMNFLKYR---
>tr|A0A0G1XBG9|A0A0G1XBG9_9BACT Thymidylate synthase OS=Parcubacteria (Uhrbacteria) bacterium GW2011_GWD2_52_7 GN=UY72_C0080G0008 PE=4 SV=1
---VFLI--AMSADIAEQEQSSLDWT-STEDTQFFVEKTKEIG------TVVMGRKTFATIG---KPLKDRRLIVMTANPDSQAGEGVEFTSNDPATLV-
-G-RLQAEGCEQVIVAGGASVYGQFFAA-LVDEVFLTVEPVLFGQGVPLAT----DFG----------------RVNLEFVAAR---
>tr|A0A0P1B8P3|A0A0P1B8P3_9BASI Dihydrofolate reductase OS=Ceraceosorus bombacis PE=4 SV=1
----ISLIAAVTRSNGLGSGGGLPWT-LPKEMSHFRRCTTVLPKDQRMNAVIMGRNTWESIPEKFRPLKGRWNVVVSRSMAASQLGATLLANSLKGALDH
LSKLQSLHLLGRTFMIGGAQLYAQAMLTLVLDTLLITRLKSDLNCDVHLPEFSDDQIRLFNEWLLLPAGAVEEKGLEYELQMWLP--
>tr|I2FY93|I2FY93_USTH4 Related to Dihydrofolate reductase OS=Ustilago hordei (strain Uh4875-4) GN=UHOR_04964 PE=3 SV=1
----LAMVAAMSLANGIGKDGGLPWR-LKGEMAYFRSVTSYVARQGTRNAVIMGRKTWASIPAKFRPLAGRLNIVISRTQSSRDLGVVRVFPSVQEALTH
LSAPREEERINRIFVIGGAQLYTDLLNLDTVDKLLVTRILAPRDCDVFFPEFTEAQYEALREYLHWSDRVRSEGETWYEYQLWEK--
>tr|R9P1S1|R9P1S1_PSEHS Uncharacterized protein OS=Pseudozyma hubeiensis (strain SY62) GN=PHSY_002776 PE=3 SV=1
----LAMVAAMSLTNGIGKDGGLPWR-LKGEMAYFRSVTSHVAREGARNAVIMGRKTWASIPPRFRPLAGRVNIVISRTSSAKDLGIVHLFASVEQALAH
LAAPQ--SGIHRVFVLGGAQLYRNMMSLDTVDQLLVTRILAPQECDAFFPEFTAQQYKSLREYLDSKDMVTNEGETWYQYQLWEK--
>tr|E7A277|E7A277_SPORE Related to Dihydrofolate reductase OS=Sporisorium reilianum (strain SRZ2) GN=sr11082 PE=3 SV=1
----LAMVAAMSLTNGIGKDGGLPWR-LKGEMAYFRNVTSQVTRQGARNAVIMGRKTWASIPAKFRPLADRVNIVISRTSSAKDLGIVQVFSSVEQALTY
LAAPQ--AKIGRVFVIGGAQLYTDLLKLDRVDKLLVTRILAPRECDAYFPEFTQEQYKSLRQYLDSVEMVTSEGQTWYQYQLWER--
>tr|A0A0D1CPU1|A0A0D1CPU1_USTMA Chromosome 8, whole genome shotgun sequence OS=Ustilago maydis (strain 521 / FGSC 9021) GN=UMAG_10394 PE=3 SV=1
----LVMVAAMSLTNGIGKDGGLPWR-LKGEMTYFRNVTSHVARQGTRNAVIMGRKTWASIPPKFRPLAGRFNVVISRTSSATDLGIARVFSSVEQALIH
LATPQ--ASISRVFVIGGAQMYTDLLDFHTVDKLLVTRILAPLECDSFFPEFTREQYQALRQYLDSRDMVTSEGETWYQYQLWEK--
>tr|A0A077RA01|A0A077RA01_9BASI Related to Dihydrofolate reductase OS=Melanopsichium pennsylvanicum 4 PE=3 SV=1
----LAMVAAMSLTNGIGKDGGLPWR-LKGEMAYFRSVTSHIPRRGARNAVIMGRKTWVSIPPKFRPLAGRINIVISRTSSATELGVVKVFESIEKALAH
LASPREGAKIGRVFVIGGAQIYTDLLRLDTVDKLLVTRILAPRDCDAYFPEFTVEQYMNLRQYLESPDMVTGEGETCYEYQLWEK--
>tr|A0A081CDP6|A0A081CDP6_CANAR Dihydrofolate reductase OS=Candida antarctica GN=PAN0_006d3007 PE=3 SV=1
----LAMVAAMSLTNGIGKDGGLPWR-LKGEMAYFRNLTSHVSQRGVRNAVIMGRKTWASIPPKFRPLSGRINIVISRTQSAQDLGVVRVFASVEDALQY
LAGPPSGAAIGRVFVIGGAQLYAELLDLDTVDKLLVTRILAPQDCDAHFAEFTREQLDALRDYLDSPDLVSREDETWYQYQLWMR--
>tr|G2QE14|G2QE14_MYCTT Uncharacterized protein OS=Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) GN=MYCTH_2303933 PE=3 SV=1
----LTLIVAATQQMGIGRNGTLPWTGLRKEMAYFARVTKRLPQQLVQNAVIMGRKTWESIPERFRPLPGRWNVVISRKAAAAAARGPVMAAGLEEALRY
LGGR---PGVGRVFVIGGAQIYRAALET-QARRVLLTRVR---ECDTFFPLRDEANADAMDAWV--PRGVQAEAGTEYEFEMWER--
>tr|G2R8V7|G2R8V7_THITE Uncharacterized protein OS=Thielavia terrestris (strain ATCC 38088 / NRRL 8126) GN=THITE_2080461 PE=3 SV=1
----LTLIVAATQQMGIGRHGTLPWTGLKKEMAYFARVTKRLP----QNAVIMGRRTWESIPARFRPLPGRVNVVVSRSWAAAAAAAASMAGSLEEALRM
LGERQQQQAIGRVFVIGGAQIYAAALAR-EARRVLLTRVR---ECDTFFPVRAEGG---MDAWV--PRGVQSEAGTEYEFEMWER--
>tr|A0A0M0UG14|A0A0M0UG14_9PEZI Dihydrofolate reductase OS=Madurella mycetomatis GN=MMYC01_G02634 PE=3 SV=1
----LTLVLAATRDMGIGRNGALPWTGLKKEMAYFARITKRLPRQGVQNAVIMGRRTWESIPPRFRPLAGRLNVVVSRGQTPQAILAVVVAKSLEEAVEY
LGRLRDGKKLGRVFVIGGAQIYKAALGMNEARRILLTRVR---ECDTFFPLRDEE----MDAWV--PRGVQAEAGTEYEFEMWER--
>tr|G0S5Q8|G0S5Q8_CHATD Dihydrofolate reductase-like protein OS=Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) GN=CTHT_0025130 PE=
----TLIVAAAARDMGIGRNGTLPWKGLKKEMAYFARVTKRPPTRKLQNAVIMGRKTWESIPPKFRPLPGRLNVVISRTVGDEVVKGVLTARSLEEALAL
LQKRHQDGDVGRVFVIGGAQIYDAALAL-ETRRIVLTRVRKEEECDAFFPVRDAQEN--MDAWV--PRGVQREAGAEYEFEMWER--
>tr|A0A061H2K2|A0A061H2K2_9BASI Uncharacterized protein OS=Anthracocystis flocculosa PF-1 GN=PFL1_05602 PE=3 SV=1
----MTVIAAATMTNGLGVAGGLPWK-LKGEMAYFRKATSTTSGQEQRNAVIMGRKTWESIPTKFRPLKDRVNIVVSRSQTEADLGIAWLFRSIEEAVRY
LRTRTTAPQVDRVFVIGGAQLYADSMADGVVDRLLITRILRPLECDAFLPEFDADQVQQLQRYLRPGDAVENEADVFYQFQMWTR--
>tr|A8Q785|A8Q785_MALGO Uncharacterized protein OS=Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) GN=MGL_3313 PE=3 SV=1
----LTAIVAASLRNGIGSQGTLPWR-LSKDMAYFRAVTMHVGPVCMKNAVIMGRHTWDSIPPKFRPLRDRINVVVSTSMTRAHLGSTLIARSLDEAVAL
LQERRMWSALGHAFVIGGAALYRHLLT--TLDSLLVTRIFTPVKCDVFLTEFSPAQVAWHAHHYALLGPILDDNGMAIQFQCWRR--
>tr|A0A0M9VP89|A0A0M9VP89_9BASI Dihydrofolate reductase OS=Malassezia pachydermatis GN=Malapachy_4271 PE=3 SV=1
----LTAVVAAGLHNGIGVSGTLPWR-LPKDMAYFRTITSYVISPPLKNAVIMGRTTWESIPPRFRPLQDRINVIVSTTMQPSDVGLTMVARSFEEAVTL
LQARRYAAALGRAFVIGGATLYQYALAPPILDHMLMTRIYGPAECDVFLPEFSPAQVAWHAAWLSVLGAIVPDRDSFVHMQLWRR--
>tr|R0F3G9|R0F3G9_9BRAS Uncharacterized protein OS=Capsella rubella GN=CARUB_v10004370mg PE=3 SV=1
---TYQVVVAATKEMGIGKDGKLPWNL-PSDLKFFKDLTLTTSDSAKKNAVVMGRKTWESIPSKYRPLCGRLNIVLTRSSGSNIAENVVTCSSIDSALDL
LAAPPYSMSIDKVFVIGGGDILRESLNRPRCEAIHLTEIDKSIDCDTFIPPIDTSAY--QPWYSS---FPICENGLRYSFTTFVR--
>tr|M4D4Y6|M4D4Y6_BRARP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Brassica rapa subsp. pekinensis GN=Bra011543 PE=3 SV=1
---AYQVVVAATKEMGIGKDGKLPWSL-PTDLKFFKELTLTTSDSSKKNAVVMGRKTWESIPTKYKPLSGRLNVVLTRSSGFDIAENVVTCRSIDSALDL
LAGPPYRLSIEKVFVIGGGEVLRDSLNGPRCEAIHLTEIDTSVECDTFVPEIDSSAY--QPWCSS---LPVCENGLRFSFTTYVR--
>tr|M4DMC9|M4DMC9_BRARP Bifunctional dihydrofolate reductase-thymidylate synthase OS=Brassica rapa subsp. pekinensis GN=Bra017662 PE=3 SV=1
---SYQVVVAATKEMGIGKDGKLPWTL-PTDLKFFKDLTLTTSDSTKKNAVVMGRRTWESIPAKHRPLSGRLNVVLTRSSGFEIAENVVTCRSLDSALEL
LAGPPYSLSIEKVFVIGGGEVLRDSLNGARCEAIHLTEIDTCIECDTFVPAVDASAY--QPWCSS---LPMCENGVRFAFTTYVR--
>tr|A9RXS0|A9RXS0_PHYPA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Physcomitrella patens subsp. patens GN=PHYPADRAFT_120817 PE=3 SV=1
---GFQIVVAATRERGIGKQGHLPWKL-PTDMKFFKTVTSVTTSSSKKNAVIMGRHTWESIPEKFRPLPGRLNVILTRSGIKS--AGVVVSESLQSALAL
IATPSYSSHVESVFVIGGGQLVSEAMASPLCEVIHLTEVEGDVECDTYMPAVDTDIF--RIWSAS---IPIVENGLRISFLTYVR--
>tr|D7MEC7|D7MEC7_ARALL Bifunctional dihydrofolate reductase-thymidylate synthase OS=Arabidopsis lyrata subsp. lyrata GN=ARALYDRAFT_656540 PE=3 SV=1
---TYQVVVAATKEMGIGKDGKLPWNL-PTDLKFFKDLTLTTSDSAKKNAVVMGRKTWESIPTKYRPLSGRLNVVLTRSSGVDIAENVVTCSSIDSALDL
LAAPPFSLSIEKVFVIGGGDILREALNGPSCEAIHLTEIDTSIDCDTFIPAVDTSAY--QPWCSS---FPICENGLRFSFTTYVR--
>tr|F0YJX9|F0YJX9_AURAN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Aureococcus anophagefferens GN=AURANDRAFT_38942 PE=3 SV=1
---LTCIVAAVAGSYGIGKDGTLPWKL-AGDMKYFKKVTSA--APGKTNACVMGRKTWLSIPPKFRPLGGRKNVVLSRNPNA-REPDVFVCPSL---DAA
VDALAGEADLGEVFVIGGGQVYASALADARCTKVLLTSIDDAADCDAVFPDPA-KGF--ASAASG-------EALVENGVAYRFE--
>tr|C5KZ80|C5KZ80_PERM5 Dihydrofolate reductase/thymidilate synthase, putative OS=Perkinsus marinus (strain ATCC 50983 / TXsc) GN=Pmar_PMAR018231 PE=4 
---QLSVIVAHTCKWGIGKDGQLPWKSLPEDMKRFKTITTGGHCNDVKNVCIMGRKTWESIPERFRPLKDRINVVISSTTSPADYQGVRICPSLL--DSL
ASLQQGEVKIGEIFVIGGASLITEAMQLPQCRTLYTTRVG--WECDVFMEKIDE-EI--WEPIAV---SRTFHSDIPFDFVDYKR--
>tr|T0R7J0|T0R7J0_9STRA Uncharacterized protein OS=Saprolegnia diclina VS20 GN=SDRG_16667 PE=3 SV=1
---LSMIVAVARATNGIGIKGQLPWRL-AGDLKRFRELTTST-ADTKQNAVVMGRKTWDSLPPKHRPLPGRVNVVLSRNPAV-RATGVLAAGDL---DEA
LGA---LTDVEHVFIIGGQSLYEEAAQHPRCTRAYITLVDGEYECDAFFPKSLASGF--VETSVS-------PAQIEKDILFQYT--
>tr|A0A022R1Q8|A0A022R1Q8_ERYGU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Erythranthe guttata GN=MIMGU_mgv1a004601mg PE=3 SV=1
---SYQVVVAATPDMGIGKEGKLPWRL-PGDLKFFKEITATTSDPNKKNAVLMGRKTWESIPPQFRPLPGRLNVVLTRSGSSDSNESVVFCGSMSSALKL
LAGPPYSFNIEKVFLIGGGQILREAFNALQCDAIHITELKSFIECDTFIPPIDMSVY--QPWYSS---SVIEENGIKYCFATYVR--
>tr|W9SFP6|W9SFP6_9ROSA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Morus notabilis GN=L484_008752 PE=3 SV=1
---TYQVVAAATRDMGIGKDGKLPWRL-PSDLKFFKEITMTTSDTGKKNAVLMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVLICGSMASALEL
LAASPYCLSIERVFVIGGGQILREALNASSCDAVHITEIETSIECDTFIPAIDSSAF--QPWYSS---FPVVENNIRFSFTTYVR--
>tr|K3ZSR0|K3ZSR0_SETIT Bifunctional dihydrofolate reductase-thymidylate synthase OS=Setaria italica GN=Si029497m.g PE=3 SV=1
---NYQVVVAATRDMGIGKDGVLPWKL-LGDLKFFKELTLATSDPAKKNAVIMGRKTWESIPVKSRPLPGRLNVILTRSGSFDFAENVVICGSMKSALEL
LASTPYCLSIEKVFVIGGGQVL-EYLNRPACEAIHLTDIQSSIECDTFIPPIDFSVF--QPWYSS---FPVVESNIRHSFVTFVR--
>tr|Q2R481|Q2R481_ORYSJ Bifunctional dihydrofolate reductase-thymidylate synthase, putative, expressed OS=Oryza sativa subsp. japonica GN=Os11g0484400 
---NYQVVVAATRDMGIGKDGVLPWKL-LGDLKFFKELTVTTADPVKKNAVIMGRKTWESLPLKARPLPGRLNIILTRSGSFEFAENVVICGSMNSALEL
LSSTPYCLSIEKVFVIGGGQVL-ESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVF--QPWYSS---LPVVESNIRHSFVTYVR--
>tr|D2W4C0|D2W4C0_NAEGR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Naegleria gruberi GN=NAEGRDRAFT_76251 PE=3 SV=1
---MEAVVAVLLNSNGIGLNGNLPWLQDTEDMKHFVSVTCSSEINQLMNAVIMGRKTWESIPSKFKPLSKNRHAIILSSKVNDDDERTTFVKNV---DEL
-FELLQNQKFNRIFIAGGTSIYKLLLPYTAV-IHYTNI---IIQVDTRFPIRLLPSD--YRNVPI---N-------SNQFIAVDK--
>tr|M1VHU6|M1VHU6_CYAME Bifunctional dihydrofolate reductase-thymidylate synthase OS=Cyanidioschyzon merolae GN=CYME_CMS462C PE=3 SV=1
---LRIVVAVQAADWGIGYNGQLPWPHIAEDLAHFKRVTTRNCAVGGKPAVIMGRHTWLSIPPERRPLSGRLNIVLTRQKPIVNEAGAYLANSL---NEA
CS-LAALHGARVAYVIGGASVFRETLAHPACDRIYLTRIRRLYPCDVFMPAIPSDEY--VEDGPS---NKHCAEQLEVEFLVYRR--
>tr|A0A0L1KPE7|A0A0L1KPE7_9EUGL Dihydrofolate reductase-thymidylate synthase OS=Perkinsela sp. CCAP 1560/4 GN=XU18_3284 PE=3 SV=1
---AINVIVAADRLGGIGVDNTLPWHL-PSDMKYFKETTTKVP-GPKVNAVIMGRKTFESIPQKFRPLAGRFNIIISSAAKSVESETPLWVSSLEGAIKA
CTAPEVIRRIHKVFVIGGASLYSACLSPSSPVFPYVHSVFMTVKCDIVVPQLAADSL--W---------------TEKGVFYLDA--
>tr|B6AE97|B6AE97_CRYMR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Cryptosporidium muris (strain RN66) GN=CMU_010300 PE=3 SV=1
---VIIIVAASTKEKGIGKGNNLPWSI-KEDLKFFREITCSTITKEKVNAIILGRKTWDSM--KRIPLKNRKVIVLSRTLQRCDNSGVSIVKSL---DEA
INLCNNDISIHKIVICGGESIYRECIEKNIVETIYLTRVSTSKEFDTYFPNIPES-F--VPILMS---QTFCCNDISYDFMIYEN--
>tr|Q27551|Q27551_CRYPV Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) OS=Cryptosporidium parvum GN=DHFR-TS PE=3 SV=1
---VSIVVAASVLSRGIGINGQLPWSI-SEDLKFFSKITSNNC-DNKKNALIMGRKTWDSI--GRRPLKNRKIVVISSSLPQD--PNVIVFRNL---EDS
IKNLMNDDTIENIFVCGGESIYRDALKDNFVDRIYLTRVALEIEFDTYFPEIPET-F--LPVYMS---QTFCTKNISYDFMVFEK--
>tr|J3MF38|J3MF38_ORYBR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Oryza brachyantha GN=OB06G26320 PE=3 SV=1
---RYQVVVAATRDMGIGKDGVLPWKV-PSDLKFFKDITMTTSNPSKKNAVVMGRKTWESIPIQFRPLPGRLNIILTRSGSFDFAENVVTCGSLDSALEL
LSTTPYCSTVEKIFVIGGGEVL-QSLNAPACEAIHLTDIESSVECDTFIPPIDLSVF--HPWYSS---YPVVENSIRHSFITFVR--
>tr|S8CLY7|S8CLY7_9LAMI Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) OS=Genlisea aurea GN=M569_06604 PE=3 SV=1
---TYQVVVAATPDMGIGKDGKLPWKL-PGDLKFFKDITSNTSDCNKRNAVIMGRKTWESIPARFQPLPNRLNVVLTRNQGPENKKDVILCNSVTAALEL
LEKPPYSVCIEKIFVIGGGQILREALNSPQCDAIHMTEIKDSVECDTFIPPVDMSLY--QPWYSS---SPREENGFRYCFTTYVS--
>tr|A0A0E0FBU4|A0A0E0FBU4_9ORYZ Bifunctional dihydrofolate reductase-thymidylate synthase OS=Oryza meridionalis PE=3 SV=1
---SYQVVVAATRDMGIGKDGTLPWKL-LGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVILTRSGSFDFAENVVICGSLDSALQL
LATTPYCLTVEKTFIIGGGEILRQSLNALACEAIHLTDIESSIECDTFIPPIDLSMF--HPWYSS---FPVVENGIKHSFISFVR--
>tr|G7J766|G7J766_MEDTR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Medicago truncatula GN=MTR_3g117080 PE=3 SV=2
---TYQVVVAATKEMGIGKDGKLPWRL-PTDLKFFKEITTTTSEPGKKNAIVMGRKTWESIPLQFRPLLGRLNVVLTRSGTFDIAENVVICRSMSSALEL
LAASPYHTSIEKIFVIGGGEIFREALNAPECEAIHLTEIQSNIECDTFMPPIDTTIF--QPWYSS---FTKVENNIRYSFTTYVR--
>tr|Q8L6F0|Q8L6F0_PEA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Pisum sativum GN=dhfrts1 PE=2 SV=1
---TYQVVVAATKDMGIGKDGKLPWRL-PTDLKFFKELTTTTFETGKKNAIVMGRKTWESIPLQFRPLPGRLNVVLTRSGSFDAKENVVICGSMSSALEL
LAASPYCTSIEKIFVIGGGEIFRDALNVPECEAIHITEIHTSFECDTFMPPIDFTTF--RPWYSS---FPKVENNIRYSFTTYVR--
>tr|F2DUZ4|F2DUZ4_HORVD Bifunctional dihydrofolate reductase-thymidylate synthase OS=Hordeum vulgare var. distichum PE=2 SV=1
---KYQVVVAATREMGIGKDGALPWKL-PSDLKFFKDLTMATSDPSKKNAVIMGRKTWESIPTKFRPLPGRLNVILTRSGSSDYAENVVTCGSLDSSLEL
LASAPYSSTIEKAFLIGGGQVL-ESLNASACEAIHLTDIESTIECDTFIPPIDPLIF--HPWYSS---SPVVENNIRHSFATFVR--
>tr|B9R7Y4|B9R7Y4_RICCO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Ricinus communis GN=RCOM_1595270 PE=3 SV=1
---RYQVVVAATRDMGIGKDGKLPWRL-PSDLKFFKELTLTTSSPGKRNAVVMGRKTWESIPLKYRPLPGRLNIVLTCSGGCDITEDVLTCGSIPSALEL
LAEAPYSFLIEKVFFIGGGQILRKTINAPGCDAIHITEIETSIECDTFIPVIDFSLF--HPWYSS---LPIVENNVRYSFATYVR--
>tr|A0A068UIN3|A0A068UIN3_COFCA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Coffea canephora GN=GSCOC_T00024757001 PE=3 SV=1
---SYQVVVAATRDLGIGKDGKLPWRL-PSDLKFFKEITVTTTDPVKRNAVVMGRKTWESIPPQFRPLPGRLNIVLTRSGSLGPADNVVCCGSISSALEL
LAESPYCSSVEKVFVIGGGQILREALNAPECEAIHMTVIEADIECDAFIPPVDGSLF--QPWYSS---PPTVENNIRHCFVTYVR--
>tr|G7JHF2|G7JHF2_MEDTR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Medicago truncatula GN=MTR_4g070670 PE=3 SV=1
---TYQVVVIATRDMGIAKDGKLPWTL-PIDQKFFEDITTVTSDPGKKNAVVMGRKSWEAIPPENRPLRGRLNIILTRSGSFEIADNVLICGSVSSAMEL
LASSPYCQSIEKVFLTGGAEIFREALHAPGCEAIHITEIEASIECDTFMPRIDFSVF--HPWYTS---FPLVENGIRYSFNTYVR--
>tr|B0BLI5|B0BLI5_LOTJA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Lotus japonicus GN=CM0216.390.nc PE=3 SV=1
---TYQAVVIATPDMGISKDGKLPWAL-PTDQKFFEEITTKTSDPGKKNAVVMGRKSWEAIPPEKRPLCGRLNVVLTRSGSFDIAENVVICGSVSSAMEL
LASSPYSMSIEKVFLTGGGEIFREALNAPGCEAVHITEIEASIECDTFMPRVDFSVF--HPWYSS---FPLVENNIRYSFNTYVR--
>sp|P51820|DRTS_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Glycine max PE=1 SV=1
---TYQVVVAATQDWGIGKDGKLPWRL-PTDLKFFKEITMKTSEPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIAENVVICGSMSSALEL
LAASPYSLSIEKVFVIGGGQIFREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTIF--RPWYSS---FPKVENNIRYSFTTYVR--
>tr|I1LQ11|I1LQ11_SOYBN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Glycine max GN=GLYMA_12G041000 PE=3 SV=2
---TYQVVVVATRDMGISKDAKLPWTL-PTELKFFEEITTTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIAENVLICGSMASAMEL
LASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASIECDTFMPRVDTNVF--QTWYSS---FPLVEDNLRYSFTTYAR--
>tr|A0A0L9V778|A0A0L9V778_PHAAN Bifunctional dihydrofolate reductase-thymidylate synthase OS=Phaseolus angularis GN=LR48_Vigan08g174300 PE=3 SV=1
---TYQAVVIATRDMGISKDGKLPWTL-PTDLKFFDEITTITSDPGKKNAVVMGRKTWESIPPEDRPLPGRLNVVLTRSGSFDIAENVIICGSVSSAMEL
LAASPYCLSIEKVFLTGGGEIFREALNVPGCEAAHITEIEASIECDTFMPRVDAFQF--QSWYSS---FPLVEDNLRYSFNTYVR--
>tr|F6I0M2|F6I0M2_VITVI Putative uncharacterized protein OS=Vitis vinifera GN=VIT_03s0038g04500 PE=3 SV=1
---TYQVVVAATRDMGIGKDGKLPWRL-PSDMKIFKDITMTVADTVKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVVICGSMASALEL
LAASPYCLSIEKVFVIGGGQILREALNAPGCDAIHITEIETSFECDTFIPAIDSLVF--QPWYSS---FPLVENNIRYSFMTYVR--
>tr|A0A067DYI6|A0A067DYI6_CITSI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Citrus sinensis GN=CISIN_1g009747mg PE=3 SV=1
---SYQVVVAATRDMGIGKDGKLPWKL-PSDLKFFKEITQITSDAGKRNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVVICGSIGSALEL
LAASPYCLSIEKVFVIGGGQILSEALNAPECDAIHITEIETRIECDTFIPSIDSSVF--QPWYSS---FPIVENNIRYCLSTYVR--
>tr|A0A067LBA7|A0A067LBA7_JATCU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Jatropha curcas GN=JCGZ_26783 PE=3 SV=1
---TYQVVVAATRDMGIGKEGKLPWRL-PSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVVICGSLTSALEL
LAASPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVF--QPWYSS---FPIVENNVRYCFATYVR--
>tr|A0A0A0LPA5|A0A0A0LPA5_CUCSA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Cucumis sativus GN=Csa_2G248730 PE=3 SV=1
---TYQVVVAATENLGIGKGGKLPWRL-PSDIKFFKNITITTSDPGKRNAVLMGRKTWESLPAEHRPLPGRLNVVLTRSGSFDIAENVIICGSITSALEL
LAASPYCLSIEKVFVIGGGEILREAMNAPECDAVHITEIETNVECDTFIPAVDKSIF--QPWYSS---FPVVEKNLRYSFNSYVR--
>tr|M0ZJD1|M0ZJD1_SOLTU Bifunctional dihydrofolate reductase-thymidylate synthase OS=Solanum tuberosum GN=PGSC0003DMG400000736 PE=3 SV=1
---TYQVVVAATQNMGIGKEGKLPWRL-PTDLKFFKGITGTTTDPTKRNAVVMGRKTWESIPIEHRPLPGRLNVVLTRSGSFDIAENVVICGSLGSALQL
LAASPYCLSIENVFVIGGGEIFRDSLNADGCDAVHITEIETDIACDTFTPAIDTSVF--RPWYSS---FPVIENKIRYSFTTYVR--
>tr|A0A059DFL3|A0A059DFL3_EUCGR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Eucalyptus grandis GN=EUGRSUZ_A01332 PE=3 SV=1
---TYQVVVAATRDMGIGKDGKLPWRL-PSDLKYFKSITLTAIDPAKKNAVIMGRKTWESIPAEHRPLPGRLNVVLTRSGSFDIAENVIICGSMSSALDL
LASSPYCLSIEKVFVIGGGQIFREALNAPACDAIHITEIETPFECDTFMPTVDTSVF--HPWYSS---FPVVENNIRYSFTTYVR--
>tr|B9H0T4|B9H0T4_POPTR Bifunctional dihydrofolate reductase-thymidylate synthase OS=Populus trichocarpa GN=POPTR_0004s16470g PE=3 SV=2
---TYQVVVAATKDMGIGKDGKLPWKL-PSDLKFFKDLTLTTMDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVVICGSMGSALEL
LAASPYCLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVF--QPWYSS---FPKVENDIRHCFTTYVR--
>sp|P45350|DRTS_DAUCA Bifunctional dihydrofolate reductase-thymidylate synthase OS=Daucus carota PE=2 SV=1
---TYQVVVAATQNMGIGKDGKLPWRL-PSDMKFFKDVTMTTSDPLKRNAVIMGRKTWESIPIQHRPLPGRLNVVLTRSGSFDIAENVVICGSMISALEL
LAGSPYCVSVEKVFVIGGGQIYREALNAPGCDAVHITEIEEHIECDTFIPLLDESVF--QPWYSS---FPLVENKIRYCFTTYVR--
>tr|B9RH79|B9RH79_RICCO Bifunctional dihydrofolate reductase-thymidylate synthase OS=Ricinus communis GN=RCOM_1447960 PE=3 SV=1
---TYQVVVAATRDMGIGKDGKLPWRL-PSDLKFFKDVTLTTTDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIAENVVMCGSFASALEL
LAASPYCLSIEKVYVIGGGQILREALNAPGCDAVHITEIETSFDCDTFIPAIDSSIF--HPWYLS---FPMVENNIRYSFATYVR--
>tr|M5VK78|M5VK78_PRUPE Bifunctional dihydrofolate reductase-thymidylate synthase OS=Prunus persica GN=PRUPE_ppa004093mg PE=3 SV=1
---TYQVVVAATREMGIGKDGKLPWRL-PSDLKFFKEVTVTTSDPGKKNAVVMGRKTWESIAPEHRPLPGRLNVVLTRSGSFDIAENVVICGSMASALEL
LAASPYCLSIDKVFIIGGGQILREALNAPGCDAIHITEIETDIECDTFIPAIDSSVF--QPWYSS---FPKVENSIRHSFTTYVR--
>tr|A0A0K9RIF4|A0A0K9RIF4_SPIOL Bifunctional dihydrofolate reductase-thymidylate synthase OS=Spinacia oleracea GN=SOVF_062630 PE=3 SV=1
---RYQVVVAATKEMGIGKDGKLPWKL-PSDLKFFKDVTLRTSDSEKKNAVIMGRKTWESIPLKHRPLPGRLNVVLTRSRGFNVGDNVVTCGSMDSALEL
LGMRPYDLSVERVFVIGGGEILREVLNGAACDAIHITEIETDIECDTFMPPVDSHLF--HPWYSS---FPLVENNIRHSFVTYVR--
>tr|W1PPK0|W1PPK0_AMBTC Bifunctional dihydrofolate reductase-thymidylate synthase OS=Amborella trichopoda GN=AMTR_s00014p00122790 PE=3 SV=1
---TYQVVVAATADMGIGKDGKLPWKL-PSDMKFFKDITMVTSVPLKKNAVIMGRRTWESIPLEQRPLPGRLNVVLTRSGSFDIAENVVMCGSMGSALEL
LAAPPYSLSIETVFVIGGGQILREAMNAPGCDAIHITNIETNIECATFIPQIDLSVF--HPWYSS---FPSVENNIRYSFSTYVR--
>tr|A0A059F2F1|A0A059F2F1_9MICR Uncharacterized protein OS=Anncaliia algerae PRA339 GN=H312_01257 PE=4 SV=1
---IPNLIAAFSKTRGIGYNNDLPWKSLSMDLKWLNYLTTYK---PNKVALIMGKNTFVSIR---KPLSKRVNIVVSSQTF----NDVVNVKSVDEALNY
ASQ-----NNLIPVFFGGSRIFEEALR--KPCKVFFTVIQEKIESDAFFPEYNILLDNITYEVNEILTKTVRENGYNFSFYVGIN--
>tr|L2GND9|L2GND9_VITCO Uncharacterized protein OS=Vittaforma corneae (strain ATCC 50505) GN=VICG_01184 PE=4 SV=1
---KINVLVAYSQNRYIGYEGDLPWKDFKGDMKYVTKLIRLY---PN-TALVVGKTTYETIK---RIKDVQILVVTSSEVAE---GNAKSFKTLPEAIDF
AKS-----SGMYVIAFGGSKIYEDAIRS-YDCKLFCTVVEE-LKGDRTFPEVDARLENVSSKVDQFLVDKFYENGYEYRFYVGYK--
>tr|I6UM68|I6UM68_ENCHA Dihydrofolate reductase OS=Encephalitozoon hellem (strain ATCC 50504) GN=EHEL_010040 PE=3 SV=1
---MFALIVAFAKNKGIGKNNRLPWPPLRTDMSWFRTLSQSVPLPSSSNAVVMGRKTWDSIP---PRFPNRTNIVLSRRPGIS-TENTLFISAFGDIEHL
RIP-----SSSMVFVIGGHDIYSLAIQS-GRAHIFATEISESLECDVFFPRIDWDRRDITREVSGLVG--FTENGITFKMFIYIK--
>tr|E0S583|E0S583_ENCIT Dihydrofolate reductase OS=Encephalitozoon intestinalis (strain ATCC 50506) GN=Eint_010040 PE=4 SV=1
---MIALIVALAANQGIGRHGKLPWKPLKTDMAWFRILSQSVPIPSKSNVVVMGRKTWHSIP---SRFQNRINVVLSRSSLPH-SQNTFFIPSFAALDHL
PLP-----PSPATFVIGGHDIYALAIQT-GRVQAFVTEVHESPECDVFFPQVDWSKRDITRDVARLVD--FNEGGISFKMFIYTK--
>tr|A0A0J8Y8H4|A0A0J8Y8H4_ENCCN Dihydrofolate reductase OS=Encephalitozoon cuniculi EcunIII-L GN=M970_080040 PE=4 SV=1
---MLALVVALASHRGIGNANALPWPPLAADMAWFRTLSQSIPLPSASNAVVMGRRTWDSIP---SRFANRINVVLSRGPARS-TENTFFIQTFEALDSL
PLP-----PSSMTFVIGGRDVYSLALQS-GRPHLFATEVFESPECDVFFPHIDWAKRDITRDVSRLID--FTENGTSFKMFLYTK--
>tr|I7AQ83|I7AQ83_ENCRO Dihydrofolate reductase OS=Encephalitozoon romaleae (strain SJ-2008) GN=EROM_011280 PE=4 SV=1
---MFALIVALARNKGIGRANRLPWSPLRTDMSWFRTLSQSIPLPSPSNAVVMGRKTWESIP---PKFPNRMNIVLSRRPGAK-TENAFFIPTFEDLSHL
DIP-----PSSMIFVIGGHDIYNLAIQN-GKAQIFVTEVFESPDCDVFFPHVDWEKRDITYEVSRLID--FTENGTTFKMFIYIK--
>tr|A0A059WV07|A0A059WV07_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---PFALIVAIAKTNGIGYENRLPWQRIPEDVEMFRNVTNDRSPPDAKNILIMGRKTYESLG---GITKNRTMVVISETMES--KSGLWSFTSLREALIF
FSNYH--HKTDRIFVIGGARLYSEAMTY-RECKTYISRIHHALEVDTFFPPISETLHSSSPDINFELWEA-----------------
>tr|A0A0R0LYK5|A0A0R0LYK5_9MICR Dihydrofolate reductase OS=Pseudoloma neurophilia GN=M153_2710004390 PE=4 SV=1
---RLNVFVAHRTQRIYANKTGIPWKQIRKEIKVINKIIS-Q---EN-VAVIMGRLTFEDIG---RPLENKQTIVVSNKMTK--REGVKIFSTFEDALTF
CRQ-----HNYTVVIFGGCAIYQAAMA--HPCKFFVTLIDD-YKGEKIFPENQVKLTCVDENVRDLM---FMENGVGYNFYVGFN--
>tr|H8ZAX0|H8ZAX0_NEMS1 Dihydrofolate reductase OS=Nematocida sp. 1 (strain ERTm2 / ATCC PRA-371) GN=NERG_00719 PE=4 SV=1
---LPVVLAAYEGNGVIGREGRLPWPSIKVDFKFMKYLTTKY---P--SGLIMGRLTYESIG---RPLPKRTSIVITSHDKENINYSVLFCKSLESAISI
CRS-----LSLQPIIFGGAAVYKEALER-YKCKLYLTEIYKIFQGDAFFPLHCIDLVNITPDVLKELSERLYENGINYAFLTGYS--
>tr|L7JWG0|L7JWG0_TRAHO Dihydrofolate reductase OS=Trachipleistophora hominis GN=THOM_1277 PE=4 SV=1
---DLNVLVCYKTKRIIGYQGTIPWMRLKSDMKFVSKLTT-T---GN-VALVMGRKTYESIG---RPLPKRVNIVLSTTMED--QNGIVVKKSFDEAINF
CRE-----KEYVTVVFGGEEVYRVALK--RRCRIWATVIDD-FCGDTFFPEVDCKYECVNEDVMPIIGECFIENGIKYSFYTGYN--
>tr|I3EN89|I3EN89_NEMP1 Dihydrofolate reductase OS=Nematocida parisii (strain ERTm1 / ATCC PRA-289) GN=NEPG_01689 PE=4 SV=1
---NLTILSAYEKTGVIGANGKLPWPTLKTDFQFMKYITTKS---P--TGIIMGRSTFESIG---RPLPNRTTIVLTSQMKNPSNYKVYFKSSLDAAVSL
CKE-----LELEPIVFGGNAVYYEAIKR-YNCTVYLTEIYKEYSGDAFFPLDLIDLIDITEEVKKELKQEVCENNVCYSFLKGRI--
>tr|L2GTQ0|L2GTQ0_VAVCU Uncharacterized protein OS=Vavraia culicis (isolate floridensis) GN=VCUG_01768 PE=4 SV=1
---DLNILVCYRAKRIIGHQGTIPWIKLKSDMKFVAKLTT-T---GN-VALVMGRKTYQSIG---RPLPKRINVVLSTTMED--HEGIVVKKSFDDAVNF
CRE-----KGYVTVVFGGEEVYREALK--RRCKIYATVIDD-FHGDTFFPETRCEYECMNEAVKPIIAECFSENGIKYSFYTGYN--
>tr|B7XJG7|B7XJG7_ENTBH Uncharacterized protein OS=Enterocytozoon bieneusi (strain H348) GN=EBI_25819 PE=4 SV=1
---KLNIMVAFREKKIIGQGMKLPWGRLNADRLFMLWAIKTG---NN-GTIIMGRKTSEVAR---FPKIKKI--IVS-QTK----EGDCYVKKFEDGIQK
CTS--------PIIVMGGEGIYKEALQ--HQCRIFCTIIEDWIKGDVFFPITFTNLNKIYIDPNKMINLIIIENNCKFQFYMYDK--
>tr|S7XSJ9|S7XSJ9_SPRLO Dihydrofolate reductase OS=Spraguea lophii (strain 42_110) GN=SLOPH_274 PE=4 SV=1
---KPNILVAYDKDKYISNCDKFPWGRISTDFMFMKDIIKED----N-IVLIMGRRTYEVSK---MKSHKK--IIVTKQKI----DGELTVDSIDKAITV
AKE-----MKRKILIFGGENIYREVLEN-YKYKLIATIFEQ-MEGDRVFPIKEDKFTNIHRYVLERL-ENFLENGKKFGFYIYEN--
>tr|T5ALK9|T5ALK9_OPHSC Dihydrofolate reductase OS=Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) GN=OCS_01584 PE=3 SV=1
----LTLIVAATRGMGIGAHGSLPWTGLRSEMRYFARVTSRVAPPQAVNAVIMGRKTWDSMPAKYRPLKDRLNIVITRSAAQPSASEPVRVPSLDHALAY
ARARHADGVVARVFVIGGAQVYAAALADPATRRLLVTVLDRDFDCDTHFPL-DLASSDQLRQWTGETSLRNEENGTPYEFQMWEKED
>tr|A0A084AY69|A0A084AY69_STACH Uncharacterized protein OS=Stachybotrys chartarum IBT 7711 GN=S7711_04357 PE=3 SV=1
----LTLIVAATRNMGIGAQGGMPWKGLRKEMQYFARVTTRLSPPGAVNAVIMGRKTWDSIPPKFRPLKGRLNIVVSRSAASAPTQEPVRVASLEQALQV
AQQR----AVGRVFVMGGAQIYDAALALPAARRVLLTSIERHFDCDTFFPL-RLGGRAELQDWTGEEEGGQEEAGTRYEFQMWEKIS
>tr|A0A086THN4|A0A086THN4_ACRCH Dihydrofolate reductase-like protein OS=Acremonium chrysogenum ATCC 11550 GN=ACRE_001440 PE=3 SV=1
----LTLIVAATRNMGIGLNGSMPWTGLRREMRYFARVTTRLATPGAVNAVIMGRKTWDSIPPKFRPLKNRLNIIVTRSAPTAPITEPIRVSSLEQALKY
AQAR----AVARVFVMGGAQIYEAALRLPETRRVLLTRIEQEFECDTFFNL-HLGGRQELEEWTGEQEGGEEEAGTKYEFQMWEKTA
>tr|E9EFM2|E9EFM2_METAQ Dihydrofolate reductase OS=Metarhizium acridum (strain CQMa 102) GN=MAC_08670 PE=3 SV=1
----LTLIVAATRSMGIGLNGTMPWTGLRKEMQYFARVTTRVVAPNSVNAVIMGRKTWDSIPAKFRPLKNRLNIIVSRQHSPTAASEPVRVSSLEQAVEF
ARTHP---TISRVFVMGGGQIYDAALKMDAAKRVLLTSIEREYECDTFFGL-DLRGSDEWRAWTGET-ATMEEGGVGYEWQMWERE-
>tr|A0A0L0NMA5|A0A0L0NMA5_9HYPO Dihydrofolate reductase OS=Tolypocladium ophioglossoides CBS 100239 GN=TOPH_00672 PE=4 SV=1
----SPLLAPGF---------------------RFLRIASAE-PPGAVNAVIMGRKTWDSIPPKFRPLKDRLNIVITRSATTAAPGEPVRVPSLEHALQC
AQAHG---AVGRVFVVGGAQVYDAALRLSAARRVLLTSIRREFECDTFFPL-DLAGREELQEWTGQQEGGQEEAGTKYEFQMWEKVD
>tr|W4GRT4|W4GRT4_9STRA Thymidylate synthase, variant OS=Aphanomyces astaci GN=H257_05315 PE=4 SV=1
--EISVVVAVARKTWGIGINNALPWK-LPSDMKRFREITTGTTDATKQNAVIMGRNTWESIPAKFRPLPGRLNVVLTRNAQEASSPQVLAASSLNDALSK
----LPSATIEHVFAIGGASVYSDALRHPACHRAYVTLVDGDFDCDAFFPSTLKQLGFV-ETE---ALGTQRENDIDFHFATYERT-
>tr|T1YSA5|T1YSA5_9TRYP Dihydrofolate reductase OS=Strigomonas galati PE=4 SV=1
--RNFQIVVAADQHEGIGDGETIPWH-VPEDVQFFKDKTMKLPKPSKMNAVVMGRKTWASVPLKFRPLKDRLSVVLTRSQTQEAQLVVVPEGGLAAALAL
LARPPYVTSVETVFCIGGAQVYAEAMAQPCVAKLTLTVTAAEAKCSRFFPFNPADTN-----------------GVRWECKYVPEN-
>tr|S9VJI1|S9VJI1_9TRYP Dihydrofolate reductase OS=Angomonas deanei GN=AGDE_02882 PE=4 SV=1
--RGFAVVVAADLAGGIGDGNQLLWK-VPEDMQFFKETTLKLPSPTKQNAVVMGRHTWGSIPIPFRPLKDRLNVVLSRTKTAEESLLVIQEGGLLGALQL
LARPPYIYSVETVHCIGGSQVYLEALRSPCVEKLHFTIHSTFDACTCFFPFTVTGNSAS-IEV-----TEEPGKVIHYVMKCVQDN-
>tr|A0A0F9LER7|A0A0F9LER7_9ZZZZ Uncharacterized protein (Fragment) OS=marine sediment metagenome GN=LCGC14_1589850 PE=4 SV=1
---LLSIIVAYAEDQVIGKDGALPWK-IKEDMAWFREQTTG-------SAIVMGRKTFESIG---RPLLNRDNIVLSSDPEYKSA-GVQTFTDLDLALKF
ASM-----RNHEVFIIGGESLYIQCLD--RVERLYITFIKDKKYGDAFFPKWTRVDFQP------IQKETFEDEVAGVNYTIFQR--
>tr|C4Z3U6|C4Z3U6_EUBE2 Dihydrofolate reductase OS=Eubacterium eligens (strain ATCC 27750 / VPI C15-48) GN=EUBELI_01781 PE=3 SV=1
---MIGLIVARSKNNVIGRNGEIPWK-IKGEQKFFKELTIG-------NIVVMGRKSYEEIG---HPLPNRQNIIVSKTMKYEGE-NLITVSSLAEALAL
S-------DNSNIYIAGGYGVYKEAIP--FVDVMYITEVDMNIEGDVFFPEFDVNDFDL------IIGETFGE-NTKYTRTTYIR--
>tr|R0CUY7|R0CUY7_9FIRM Dihydrofolate reductase OS=[Clostridium] clostridioforme 90A6 GN=HMPREF1083_03826 PE=3 SV=1
---MIGLIVARSKNNVIGKNGNIPWK-IKGEQKQFRELTTG-------NVVIMGRKSYEEIG---HPLPNRMNIVVSTTTEYQGD-NLVSVKSLEDALLL
A-------KGRDVYISGGYGLFKEALQ--IVDKMYITEVDLNIEGDTFFPEFDINDFEV------LIGETLGE-EVKYTRTFYVR--
>tr|R7HR44|R7HR44_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:411 GN=BN648_01083 PE=3 SV=1
---MVGLIVAYAKNRVIGNKGQIPWR-IKGEQKRFKELTTG-------NVVIMGRRTYEEIG---KPLPNRNTIVVSKTANYQFE-NCITVGSLKEALEA
A-------GNRTVYISGGAGLYKEAIP--FVDKMYITEIDAEIEGDTYFPEFDTSLFQR------EVEESFDG-ELPYQYVTYTK--
>tr|U2BFK4|U2BFK4_9CLOT Dihydrofolate reductase OS=Clostridium sp. KLE 1755 GN=HMPREF1548_01821 PE=3 SV=1
---MIALIVARSRNNVIGRNGQIPWK-IKGEQAQFRKLTTG-------NVVVMGRKSYEEIG---HPLPNRMNIIVSLSANYSGE-NLVTVSSLQEAIEA
A-------GDANIYVCGGYGLFMEAIP--IVEKMYITEIDIEIKGDVFFPEFNKDDFDI------VVSKTEGE-DIKFTRTIYTR--
>tr|R5YPT0|R5YPT0_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:156 GN=BN504_00951 PE=3 SV=1
---MIGLIVARSKNNVIGKNGKIPWK-IKGEQKQFKELTTG-------NVVIMGRNSYDEIG---RPLPNRETIVISNTKKYIGE-NLHTASSVKEAIEF
A-------KGKDVYIAGGYGVYKEAIP--LVDVMYITEININVEGDVFFPEFDDNNFNI------SIVETSEN-NELFIRKIYRR--
>tr|U2LUU7|U2LUU7_9FIRM Dihydrofolate reductase OS=Ruminococcus callidus ATCC 27760 GN=RUMCAL_02305 PE=3 SV=1
---HIALIAACDRSRAIGKNGKIPWN-IAGEQQRFRQLTTG-------QTVIFGRRTYEEIG---HPLPCRETIVVSASRQFSGS-HLQTVPTLAEALAA
A-------KTEWVFISGGARLYAEAMP--LAEMLYLTEIDGFFQGDVFFPPLLAGQFAR------VAEERHDG-EIPYVYVTYRR--
>tr|R5YMT4|R5YMT4_9FIRM Dihydrofolate reductase OS=Eubacterium sp. CAG:156 GN=BN504_00297 PE=3 SV=1
---MIALIVAFAKNQVIGNKGCIPWE-IKGEQKRFRELTTG-------NVVIMGRRSYEEIG---KPLPNRTTIVISNTKKFEGE-NCFTARTLEEAIEL
A-------GDKDIYIAGGVRLYEEVLP--FVEKMYITEINLDIEGDTFFPYFDQEKFVK------EVNEKHTG-EIPYTYVTYTR--
>tr|B9ECC1|B9ECC1_MACCJ Dihydrofolate reductase OS=Macrococcus caseolyticus (strain JCSC5402) GN=MCCL_plsB0051 PE=3 SV=1
---IISLIAAISSNYVIGKDKDIPWK-IPGEQVRFKDLTMG-------KSVIMGRKTFESIG---QPLPNRKTIIISKSKDINYN-NCLTVESLERAFNL
L-Q-----QEDEIFIAGGGEIYKESLP--FADRIYLTIIEKEYEGNIFFPMFNKDEFEI------TYQQKVEG-FIPYTYFTYER--
>tr|R5VRL1|R5VRL1_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:167 GN=BN512_01199 PE=3 SV=1
---MIALIAAMTPDRVIGREGRIPWN-IPGEQKRFKELTMG-------HTIVMGRRTYEEIG---RPLPGRQTIVVSTTKNFDQP-GCRTAGSLTEALAL
S-------AGEDVYISGGSRLYEEALP--LADVLYLTEIESRIEGDAYFPEFDAQKYQK------CVEERHEG-EIPYTYVTYRK--
>tr|C2KUX7|C2KUX7_9FIRM Dihydrofolate reductase OS=Oribacterium sinus F0268 GN=folA PE=3 SV=1
---MISIIVAVAKGGAIGKEGKMPWK-IPGEQRQFKDLTTG-------HVVIMGRTSYEEIG---HPLPERTNIVVSKTKVFSGE-NLYTVKSLQEAIER
A-------GQEEIFIAGGAEIFQEALP--LADKIYMTYVDMEVPADRFFPDFPEEEYTR------EELEKVGG-ETSYLRVLYTK--
>tr|E6MJL0|E6MJL0_9FIRM Dihydrofolate reductase OS=Pseudoramibacter alactolyticus ATCC 23263 GN=folA PE=3 SV=1
---MIALIAACDRHRLIGDHGRIPWR-IPGEQARFQKLTTG-------HVVIMGRQTYAEIG---RPLPRRQTIVLSRNQTFRAP-GCRIAASLAEALRL
GAA-----FSDQLFIAGGAAVYSKALP--LADVLYLTEIDAAYVGDTYFPAFDPALFTK------TLDAHISG-DPSYDYYTYLR--
>tr|A0A059WW78|A0A059WW78_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---KISIIVAMTENRVIGKENDIPWR-IPGEQKRFRSLTTG-------KTVIMGRKTFESIG---KPLPNRRNLVITRDRTYVAE-GCEIVGSLQEALAL
T-K-----DEAEVFIGGGETIYREALP--IADRIYLTTIHSKIDGDTFFPEIG-DEFQP------VECIDVNG-EPSYTYQTLER--
>tr|A0A0L6JIC7|A0A0L6JIC7_9FIRM Dihydrofolate reductase OS=Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933 GN=Bccel_0740 PE=3 SV=1
---MISIIVAVSNNNVIGNNGIIPWK-VKGEQNRFKELTIG-------KTIIMGRKSFEEIG---KPLPNRKTILISNTQSINNE-NCITVKSLIEAINL
V-K-----DEDEIFIAGGGQVYRDALP--YTDRIYITVIDKTINGDIYFPQISKTEFEK------IYEEHVDG-EIPYTYYTYVR--
>tr|D9SPH5|D9SPH5_CLOC7 Dihydrofolate reductase OS=Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B) GN=Clocel_0240 PE=3 SV=1
---MISLIVAVAKNNVIGNNGIIPWK-IKGEQKRFKELTIG-------KTIIMGRKSFEEIG---KPLPNRKTILISNTQCIESE-NCTTVNSLSEAFDL
T-K-----DEDEVFVAGGGQVYKESFT--YADRIYITVIDKIIDGNVYFPEISSDDFIK------SYEERIDA-EIPYTYYTYER--
>tr|K6TJC2|K6TJC2_9CLOT Dihydrofolate reductase OS=Clostridium sp. Maddingley MBC34-26 GN=A370_04738 PE=3 SV=1
---MISIIVAVSKNNVIGNNGVIPWK-IKGEQKRFKELTTG-------KTIIMGRKSFQEIG---KPLPNRKTIIISNTENIEFD-NCITVKSLIEALNL
A-K-----GEEEIFIAGGGQVYKEVFP--LCNRIYITVIDKIIEGNVYFEHINEEEFIK------NYEERIEG-EIPYTYYTYER--
>tr|F7KSI7|F7KSI7_9FIRM Dihydrofolate reductase OS=Lachnospiraceae bacterium 5_1_57FAA GN=HMPREF0993_01929 PE=3 SV=1
---MIGLIVARSKNNVIGKNGKIPWK-IKGEQKQFRELTTN-------KAVIMGRKSYNEIG---HPLPNRLNIIVSNTANYTGE-NLITVHSLNEAIQV
A-------GNKDIFVIGGYSLYKEALP--IVDKMYITEIDIEVSGDVFFPQFNIDNFEL------SIGETFGN-DIKYTRTLYTR--
>tr|A0A0G4K5I6|A0A0G4K5I6_9SPIR Dihydrofolate reductase OS=Brachyspira suanatina GN=BRSU_0900 PE=3 SV=1
---IVSLIAAVDSKNGIGLNGIMPWGHIKEDMQFFRSTTTG-------YAVVMGRVTFESLGS--KPLPNRKNIVISSNINNELS-NLFYEKSFEDTISK
L--------NNQIFIIGGESIYKKSLD--YADIIYLTHIDKNYNCDRFFPEIDTSLFKS------DKLKTFLYNDINVNIIKYTR--
>tr|D5U4M6|D5U4M6_BRAM5 Dihydrofolate reductase OS=Brachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) GN=Bmur_0164 PE=3 SV=1
---IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTG-------YPVIMGRVTFESLGC--KPLPKRKNIVISSSINNEF---LFFDTSFENALSK
L--------HNQIFIIGGESIYKKALD--YADIIYLTHINKNYNCDRFFPEVDKTLFNS------NKLKSFIYDNINIDIIEYSR--
>tr|L8XT57|L8XT57_9SPIR Dihydrofolate reductase OS=Brachyspira hampsonii 30599 GN=H263_07161 PE=3 SV=1
---IVSLIAAVDSKNGIGSNGVMPWGHIKEDMQFFRSTTTG-------YAVVMGRVTFESLGS--KPLPNRKNIVVSSNSNTGLL-ELFYEKSFEDAISK
L--------NNQIFIIGGESIYKKALD--YADTIYLTHIDKDYHCDRFFPQIDISLFQA------NKLKTFLYDDINISIIKYTR--
>tr|C0QWN0|C0QWN0_BRAHW Dihydrofolate reductase OS=Brachyspira hyodysenteriae (strain ATCC 49526 / WA1) GN=folA PE=3 SV=1
---IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTG-------YAVIMGRVTFESLGS--KPLPNRKNIVISSNVNTELL-NLFYEKSFEDSISK
L--------NKQIFIIGGESIYKKALD--YADMIYLTHIDKDYHCDRFFPEIDTNLFQS------DELKTFFYNDISVNIIKYTR--
>tr|K0JIJ4|K0JIJ4_BRAPL Dihydrofolate reductase OS=Brachyspira pilosicoli WesB GN=folA PE=3 SV=1
---IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTG-------YAVVMGRVTFDSLGG--KPLPNRKNIVISSNK-NELS-DLFYDDNFENAISK
L--------HNQIFIIGGESIYKRAMD--YADKIYLTHINKDYNCDRFFPEVDSKLFSS------RILKNFVYDDIDVSIVEYTK--
>tr|R5LQS7|R5LQS7_9SPIR Dihydrofolate reductase OS=Brachyspira sp. CAG:700 GN=BN758_01285 PE=3 SV=1
---IISLIAAVDSKNGIGLNGIMPWGHIKEDMEFFKKTTLG-------FPVIMGRITFESLKN--KTLPNRKNIVISSKINEEYL-NLSYESSFENTLSK
L--------QKQIFIIGGESIYKKAID--YADIIYLTHINKNYNCDRFFPNVDKNIFTK------EELKKFEYNSINISICKYTR--
>tr|G0EJ73|G0EJ73_BRAIP Dihydrofolate reductase OS=Brachyspira intermedia (strain ATCC 51140 / PWS/A) GN=folA PE=3 SV=1
---IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTG-------YAVVMGRVTFESLGS--KPLPNRKNIVISSSINNDLL-ELFYESSFENTISK
L--------NNQIFIIGGESIYKKALD--YADIIYLTHIDKDYNCDRFFPQIDTKLFQS------SKLKTFFHNDININIIKYTR--
>tr|Q5D6W5|Q5D6W5_ECOLX Dihydrofolate reductase type IIIb OS=Escherichia coli GN=dfrA3b PE=3 SV=1
---TKQAIFAVAENLAFGLGGGLPWDTLKDDLQFFKRLTEG-------TDLVMGASTYRTLPL--LPTNNRQFIVVSNTEEPSLN-VHVVSPEFKAFLS-
---------SRNLTIIGGSSLLTVDILS-KMDKIIMTTVYGSFDADVYLPTEVVSYVTG------KASNATLNSD--AKMAVYYG--
>tr|Q0FG98|Q0FG98_9RHOB Dihydrofolate reductase OS=Rhodobacterales bacterium HTCC2255 GN=OM2255_04415 PE=3 SV=1
---MIKAILACDDEWGIGKNGDLPWPHNPADLRWFKNNTLN-------SVIVMGKSTWDSLPR--KPLPNRENLIVTTSKQEFGY-DFINFSDLEVKLSS
T--------INNIWIIGGAKLISGLIN--FIEEFHLSRINGNFNCDTFLPSDLIEKFIL------SKTDVSDG----VNFDIWCK--
>tr|S5MVZ1|S5MVZ1_9CAUD Dihydrofolate reductase OS=Sinorhizobium phage phiM12 GN=dfrA PE=3 SV=1
---NISAIVAMDETGGIGKNGTLPWEKDPADMRWFQRYTKG-------GTLIMGRKTYEDEAF-PKPLPDRLSVVIGGLKDYDYP-NIFLSKIDWDMFK-
---------FQRPILIGGATLYNKAIREKVIESLYVTSMLGDYGCDTFIDKEALANYEG------KHADWHR--D--FPLFVYTK--
>tr|I0XC03|I0XC03_9SPIO Dihydrofolate reductase OS=Treponema sp. JC4 GN=MSI_01250 PE=4 SV=1
---KIAIVVAFEKNRGIGKDGKIVWD-FPTDRAYYKTLTLG-------NFVIFGRRTFEEFG---RALPGRINIVVSSTKKFEGE-NLYTVKNLEAAIEL
AEK-----INPIIFLCGGAGIYREGMN--LAETIYTTQIDADYDCDTFFPEIDESKFKI------SEKKVTDEKAVKLSFITYSL--
>tr|A0A088C306|A0A088C306_9CAUD Dihydrofolate reductase OS=Shewanella sp. phage 1/4 GN=S14_36 PE=4 SV=1
---SIKMIIATGANFEIGQAGKLPWGYIKEDLQYFKDKTLG-------CPVIMGNTTFKSLPFKG-GLPDRYNLVLTRESLCTYT-MVYVSDTYKVNLKF
I--------EADTWVIGGASVYQQLLP--YVDEIHWTTVEDIFPADTYFDMGFL--YEG------GWERVSDYLVENVSVSVWKR--
>tr|A0A088C3F1|A0A088C3F1_9CAUD Dihydrofolate reductase OS=Shewanella sp. phage 1/40 GN=S140_33 PE=4 SV=1
---TIKMIVATGANFEIGQDGKLPWGYIKEDMQYFQDQTSS-------HIVVMGRKTQDSLSQKNKTLPRRINYVVSSEGNGSQE-D------YRVTMEA
L--------YKDTWIIGGASIYQQLLP--YVDEIHWTLVEDSFPADTYFDMSFL--QEG------GWEFD-DIRLNNAGVSVWKR--
>tr|A0A059WPA4|A0A059WPA4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---HISMSCAMTECGVIGNKGKMPWRRLGRDLRRFRELTEN-------TAVVMGPKTYASLPEKYRPLPRRLNIILTTNQNYKAP-EVLIAHDPRQVLEL
A--------YVELFVIGGAMIYTSFLP--IAEHLFITYVKSRAKGDTHFPHWEKSRWRE------VWVESAYGDSYPTRFAEYRR--
>tr|A0A068UY95|A0A068UY95_COFCA Uncharacterized protein OS=Coffea canephora GN=GSCOC_T00036294001 PE=4 SV=1
-----EVVVAATSKMGIGMGGKVPWKLP-TDLKFFKDITVTTSDPTKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDITANVVICGSLLSALEL
LAASPYCLSIEKVFVIGGGEILKESLNAPECDAIHITEIDADIECDTFIPAIDSSEFQPW-----YSSFPSIENKLRHSFTTYVR--
>tr|A0A061FK09|A0A061FK09_THECC Thymidylate synthase 1, putative OS=Theobroma cacao GN=TCM_034096 PE=3 SV=1
-----QVVVAATREMGIGKDGKLPWRLP-SDLKFFKELTMTTSDPEKKNAVVMGRKTWESIPLEYRPLPGRLNVVLTRSESSKITGNVVICGSISSALQL
LAEVPYCLSIEKVFVIGGGQIFRETLNAPGCEAIHITEIDTSIECDTFIPAIDLSCFRRW-----YSSKPLVENGIRFSFKTYVR--
>tr|A0A067HA24|A0A067HA24_CITSI Uncharacterized protein OS=Citrus sinensis GN=CISIN_1g024737mg PE=3 SV=1
-----QVVVAATHDMGIGKDGKLPWNLP-SDLKFFKQLTMSTSDPGKRNAVVMGRKTWESISPLYRPLPGRLNVVLTHSGSFNISLNVEICRSIHLALEL
LAEPPYCSSIEKVFVIGGGQILREALNAPECDAIHITKIETSIECDTFIPAIDLSLFQQR-----YSSQPLVENNIQFSFVTYVR--
>tr|K7TWH4|K7TWH4_MAIZE Uncharacterized protein OS=Zea mays GN=ZEAMMB73_826351 PE=4 SV=1
--------------MGIGKDGVLPWKLP-GDLKFFKELTLTTSDLVKKNAVIMERKTWESIPVKSRPLPGRLNVILTRSGTFDFTVNVVICGSMESALEL
LASTPYCLSIEKVFVIGGGQVLREYLKGPACEAIHLTDIQSSIECVTFIPPVDFSVFQPW-----YSSFPVIESNIRHLFVSFVR--
>tr|A0A0Q4NG38|A0A0Q4NG38_9PSED Uncharacterized protein OS=Pseudomonas sp. Leaf58 GN=ASF02_09025 PE=4 SV=1
---KINLILVTGKNGEVGDNGALPWKN-PEELENFKNATY-------SHPVIYGRNTLVSMG---RVLPGRRNIIVSSQLKYI--PGAEIAPSLQAAIDM
-VQGVP-----EAFVIGGVGLWMEALPI--ADAALISEIDFSGDVDTVLPKTFFVDLHALYEMKG----------------------
>tr|A0A0N1JKP5|A0A0N1JKP5_PSEAV Dihydrofolate reductase type I OS=Pseudomonas amygdali pv. lachrymans GN=AC499_0711 PE=4 SV=1
---QLNLILACGLHGQIGHNGALPWKI-PEELQFFKDVTS-------GRPIIMGRGTFESIG---RPLPNRRNIIVSSKLKYI--PGAECVSSLEEALAK
-VSGVP-----EAFVIGGIDLWTEALPL--ADLALISQVEFDEEVDTSLPESFFDDLRATYYMAA----------------------
>tr|Q9EXQ6|Q9EXQ6_CAMJU Dihydrofolate reductase OS=Campylobacter jejuni GN=dfr1 PE=3 SV=1
---KLSLMVAISKNGVIGNGPDIPWSA-KGEQLLFKAITY-------NQWLLVGRKTFESMG----ALPNRKYAVVTRSFTSDN-ENVLIFPSIKDALTN
L--KKIT---DHVIVSGGGEIYKSLIDQ--VDTLHISTIDIEPEGDVYFPEIPSN-FRPVFTQDF----------------------
>tr|E4KY68|E4KY68_9FIRM Dihydrofolate reductase OS=Peptoniphilus harei ACS-146-V-Sch2b GN=folA PE=4 SV=1
----MKLLILVDNKNAIAKDGKQIMFV-DNDLEMFKNYTT-------NNIIVMGRKTLDDIG---RQLPNRISVVFTRSKREDN-EDLFYIDSVEKL-DK
IIEAYPD---KEVFVIGGAEIVKLLWDR--IDELIVTRVDTVEGADTFIPDFDAFKLIDKTEIED----------------------
>tr|A0A0P7C0R4|A0A0P7C0R4_9BACT Dihydrofolate reductase OS=Leadbetterella sp. JN14-9 GN=AFM12_16630 PE=4 SV=1
---KISIIAAMSQNRAIGFKGSLPWPEPPADWEHLEKVTK-------GKKMIMGRKSYEDKH---R-SSEAGNFVLSSQDLELE-DNFAHVKSLEEALEL
C---KNE---DEVFVIGGEGVFEAALPK--CTTLYLTKVLKD-EGDTFFPEFEHLAFKVEKIKRF----------------------
>tr|R7HL81|R7HL81_9FIRM Dihydrofolate reductase OS=Firmicutes bacterium CAG:321 GN=BN608_01105 PE=3 SV=1
---NLSLIAAIGENGELGYNNSLIWRI-REDLQFYKEMTM-------GKKIIMGRKTLESMP---LALEGRQPIVLTSKPLENC-TNLEVYHDLDSLLNY
-ISE-TN---TEFMVVGGSKVYEQLLPY--VQIMYLTEIKRE-YADSFFPYFDKEEWNI-TEIGD----------------------
>tr|R5TIH5|R5TIH5_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:762 GN=BN775_00010 PE=4 SV=1
---NLYLIGAIGKNNELGYNNDLIWRI-KEDLNFFKEQTM-------GNYIIMGRNTYLSMP---KNLKGRKYIILTSNKNIVY-DNAMVFNNKESLLDF
-INSNQD---LIFYVIGGSKIYNLLIDE--VNILYLTEIDDSKDATVYFPLFDKDNYDI-TIGDL----------------------
>tr|V2Y4R7|V2Y4R7_9FIRM Dihydrofolate reductase OS=Catonella morbi ATCC 51271 GN=GCWU0000282_001126 PE=4 SV=1
---KIKLIAAVDLRFGIGKDGSLLFKI-PEDLRLFKQLTT-------GNIVLMGRKTFESIGC--IPLTDRINIVISSAKKYEN-EDVINFDNYKTAIEY
CKQIFSD---KDLYIIGGGKIYEQGIKY--ADEIILTKYNKVEDVDTYFPVDIMDNFSEADVIME----------------------
>tr|A0A059WWJ0|A0A059WWJ0_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKGGKLPWHY-SADMKFFKETTT-------GNAVVMGHNTWRSL----KPLPNRLNIVLSRKEIKPQ-PSVIVLKDMLSVLSL
K--KFLA---CDLFVIGGEQVYRSFLPH--IDRWIVTQIPLAEGADTFMPEGYLKNFSPYDSQQL----------------------
>tr|A0A059WSQ5|A0A059WSQ5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKGGKLPWHY-SADMKFFKETTT-------GNAVVMGHKTWLTL----KPLPNRLNIVLSRQEIEPA-ESVVILRDVDSVLAM
N--KDLK---GDLFVIGGAQVYQAFLPY--IDKWIVTEVPLTEDADTFVPPNYLEGFKQIGSKDL----------------------
>tr|A0A059X7X8|A0A059X7X8_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIAIVAVDRNGAIGRDGKLPWHY-SSDMKFFKETTT-------GNSCVMGYKTWLTL----KPLPNRLNIVLSRQEIAPQ-DSVVLLRDVESVLSL
A--EELN---GDLFVIGGEQVYRSFQPH--IQKWIVTEVPLSEGADAFVPKDYLEGFELTGTRKL----------------------
>tr|A0A059X2N6|A0A059X2N6_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKDGKLPWHY-SADMKFFKETTI-------GNACVMGYTTWLTL----KPLVDRLNIVLSRTDVEPH-ESVVVYRDVESVLEK
A--KTLD---GDLFVMGGEQVYRSFLPH--IEKWFVTEVPLSEGADTFMPTNYLDGFDLTASKML----------------------
>tr|A0A059X8N5|A0A059X8N5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDQNGAIGKGGKLPWHY-PADMKFFKETTI-------GNACVMGYKTWLTL----KPLVDRLNIVLSRSDVEPQ-ESVMVCRDVESVLEL
L--KTLN---TDLFVIGGEQVYRSFLPH--IDKWLVTEVPLIEGADTFMPQNYLEGFDLTESKRL----------------------
>tr|A0A059X5C6|A0A059X5C6_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDKNGAIGKDGKLPWHY-SADMKFFKETTI-------GNACVMGRKTWLTL----KPLPNRLNIVLSRNEVEPQ-ESVLLLRDVDSVLAV
A--KNLD---CDLYVIGGEQIYKAFLPH--IDRWLVTEVPLTNDADTFIPREYLQEFEGIEAREI----------------------
>tr|A0A059WQH0|A0A059WQH0_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKGGKLPWHY-SADMKFFKETTT-------GNAVVMGHNTWRSL----KPLPNRLNIVLSRQEIEPK-ESLLVLQTIESVLSI
A--KKLE---TDLYVIGGEQVYQSFLPY--IDKWIVTEVPLTERADAFVPENYLEGFRVVGSREL----------------------
>tr|A0A059X7Y5|A0A059X7Y5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRQGAIGKGGKLPWHY-SADMKFFKETTI-------GNACVMGYKTWLTL----KPLPNRLNIVLSRSEIEPL-ESVVVLRDVESVLQK
A--DALT---RDLFVIGGAQVYHAFLPH--IDKWIVTEVPLTEGADTFIPENYLEGFSLADTKDL----------------------
>tr|A0A059WVW9|A0A059WVW9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---SIIGIVAVDRKGAIGKGGQLPWHY-SADMKFFKETTT-------GHACVMGHKTWLTL----KPLPNRLNIVLSRQQIEAQ-ELVAVHRNVESVLAL
S--RDLK---SDLFVIGGSKIYRAFLPY--IEKWIVTEVPLTEGADTFVPANYLEGFHRVGSKEL----------------------
>tr|A0A059WPV5|A0A059WPV5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKGGKLPWHY-SADMKFFKETTT-------GNACVMGYKTWLTL----KPLPNRLNIVLSRQQIEPQ-DSVIVCRDVESVLSE
A--RDFK---GDLFVIGGEQVYRSFLPY--IEKWIVTEVPLTEGADAFVPENYLDGFTNSGSKQI----------------------
>tr|A0A059X0L6|A0A059X0L6_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---SIIGIVAIDRNKAIGKGGKLPWHY-SSDMKFFKQQTI-------GNACVMGHRTWLSL----PPLPDRLNIVLSRTEIEHQ-PAMITLRDKSAVLSL
N--SYLK---CDLYVIGGAQVYRTFLDD--IDEWVVTEVPLSDGADAFMPEGFLRGFEPYEVRDL----------------------
>tr|A0A059X9N2|A0A059X9N2_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNLAIGKGGQLPWHY-SADMKFFKATTT-------GNAVVMGRRTWLTL----KPLKDRQNIVLSRSDVSNH-DSVMVMKDVEAVLEF
A--RTID---QHLFVMGGAHVYESFLPY--VERWVVTEIPLNEGADTFMPANFLDGFEMYEMRQL----------------------
>tr|A0A059WL45|A0A059WL45_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MVIGIIAIDRNRAIGKDGKLPWHY-SADMKFFKETTT-------GHACVMGYNTWLSL----KPLPNRLNIVLSRKELEPQ-ESVLVLRDVESVLAK
A--KTLS---CDLYVIGGEQVYRAFLPH--VEKWLVTEVPLSEGADTFAPEGFLDGFRLDGTQTL----------------------
>tr|A0A059WQ38|A0A059WQ38_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKDGKLPWHY-SSDMKFFKQTTT-------GNACVMGYHTWLTL----NPLPNRLNIVLSRQEIPPQ-ESLVVMRDVDAVLAM
A--KVLE---TDLFVIGGAQIYQAFLPY--IDKWIVTEVPLSAGADTFMPDNYLEGFELKGSQEL----------------------
>tr|A0A059WKX9|A0A059WKX9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRQGAIGKGGKLPWHY-SADMRFFKETTT-------GNACVMGYKTWQTL----KPLPNRMNIVLSRVEIEPQ-DSVLLVRDVDSVLQL
A--ESLS---CDLYVIGGAKVYRAFLSH--IDKWLVTNVPLTAGADTFVPPNYLDGFILAESIDL----------------------
>tr|A0A059WW89|A0A059WW89_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDQNGAIGKGGKLPWHY-SSDMKFFKETTI-------GHACVMGYKTWLTL----KPLPNRLNIVMSRQEIEPQ-ESVIVIRDVESVLSR
A--ENLA---GHLFVIGGEQVYRAFLPH--IERWLVTEVPLKEGADTFVPAGYLDGFSETAVKKL----------------------
>tr|A0A059WVJ6|A0A059WVJ6_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVDRNGAIGKGGSIPWHY-SADLKFFKEQTT-------GHACVMGRRTWLSL----KPLKERLNTVLSRSDAGGQ-EGILALPDKRSVLAL
A--PYLS---CNLYVIGGEQIYRTFQNE--IERWIVTEIPLSEGADTFMPQDFLRNFKPHRSISL----------------------
>tr|A0A059X927|A0A059X927_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDKNGAIGKDGKLPWHY-SADMKFFKETTI-------GNACVMGHKTWLTL----KPLPQRLNIVLSRKEIEPQ-ESVIVLRDLESVLAK
A--SSLD---CDLYVIGGEQVYNAFLPH--IDRWLVTEVPLTNDADTFIPKEYLRDFECIESSEI----------------------
>tr|A0A059WSJ2|A0A059WSJ2_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNGAIGKDGRLPWHY-SADLKFFKATTT-------GNAIVMGHNTWKTL----TPLPNRLNIVLSRKEIPPQ-ESVLVLRDVESVLKL
E--KDLK---TDLFVIGGAQIYSAFLPH--IEKWIVTEVPLSEGADTFMPQNYLEGFEIIETKQL----------------------
>tr|A0A059X7E6|A0A059X7E6_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAISENFAIGRDGKLPWHY-SADLKHFKETTM-------GGTLVMGSKTWRSI----GALPGRQSIVLSRSIIDLP-DGVLLCHSAKQVLER
S--ERFP---GSPFIIGGAAVYETFQDD--INRWIVTRIPQTDDADVYMPLQFLDDFERVDSKEI----------------------
>tr|A0A059X198|A0A059X198_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAISENYAIGRNGKLPWHY-SADLTHFKETTM-------GGTLVMGSSTWRSI----GALPGRQSIVMSRATLELP-EGVLLCHSVKQVLER
A--ERFD---GDVFIIGGAGVFESFQDE--IQRWIVTRVPEADDADVFMPVQFLDDFELTDRKEI----------------------
>tr|A0A059XEJ4|A0A059XEJ4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAISENFAIGRDGKLPWHY-SADLKNFKESTM-------GGTLVMGSKTWGSI----GALPGRQSIVLSRTIEDLT-DDVLLCHSAKQALER
S--ERFP---GDVFIIGGAGVYETFQDD--IKRCLVTRIPETDDADVYMPLQFLDDFERVDSKEI----------------------
>tr|A0A059X1R1|A0A059X1R1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNLAIGKDGKLPWHY-SADMRFFKETTI-------GNAVVMGRHTWLTL----KPLKDRQNIVLSRGSVQPT-DSLIVKRDVEDVLGF
A--SKLD---CHLFIIGGAKVYESFQPY--IQRWIVTEIPLSEGADTFMPANFLAGFKMYEVRQL----------------------
>tr|A0A059X676|A0A059X676_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---MNIGIVAVSENYAIGKGGKLPWHY-SADLKNFKETTT-------GGIVVMGSHTWRSI----GPLPDRTNMVLSHSQPDLP-EGVILCHSKKQILER
A--ERLE---GDVFIIGGAGVFEAFQDE--IERWIVTRIPETEDADVFMPVQFLDDFELTSQKTI----------------------
>tr|A0A059XAL1|A0A059XAL1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---SIIGIVAIAKNLAIGKNGKLPWHY-SADLKFFKQTTL-------NNTIVMGWNTWKEIG---GPLPKRLNVILSRSNLENQ-PSLILLRNKQEVLAL
K--NYLK---GDLFLIGGAQTFADFSDV--IDKWIVTEIPESADADTFMPANFLEDFEMKEIVSL----------------------
>tr|W9EH55|W9EH55_9LACO Dihydrofolate reductase OS=Lactobacillus florum 8D GN=B808_498 PE=3 SV=1
---MLAFIWAEAHNHVIGSKGELPWHL-PDDLQFFKRQTS-------QHQILAGARTYASFK---RPLPNRKNLVLTHRATEFP-AEVLVFSTLSEFLQY
-ANEFKN---DLIFVVGGSIIFKQLLPY--TQFLYRTTIDATPGDTYMIPI-NYDDFVRQEVIAG----------------------
>tr|A0A0R2JPF6|A0A0R2JPF6_9LACO Dihydrofolate reductase OS=Lactobacillus lindneri DSM 20690 = JCM 11027 GN=IV52_GL000388 PE=4 SV=1
---MLAYIWAEAKNHVIGKNGNLPWNI-PDDMKFFKEQTL-------NHQILAGYTTYKSFG---RPLPHRKNLVLTHRPKQFP-VDVKVFSDENDFLQY
-ANKYKD---DIIFVVGGRKVYEALLPY--VKLLYRTSIDKEDGDTKMIPI-DYSKFEKIKEIPG----------------------
>tr|A0A0R2BNJ7|A0A0R2BNJ7_LACSN Dihydrofolate reductase OS=Lactobacillus sanfranciscensis DSM 20451 GN=FD36_GL000956 PE=4 SV=1
---MLAFIWAEAANKVIGKDGNLPWHI-ADDMAFFKETTL-------NHQIICGYTTFKSFG---RPLPKRKNLILTHRPSEFP-ESVTVFNSKDDLLQY
-ANKFPN---EMIFVVGGRAIYQELLPY--TDYLYRTKIDKNDGDTKMVEI-NYDNFKLIKKIDG----------------------
>tr|A0A0R2EDT5|A0A0R2EDT5_9LACO Dihydrofolate reductase region OS=Lactobacillus fructivorans GN=IV37_GL000297 PE=4 SV=1
---MLAYIWAEASNHVIGKNGKLPWHL-PDDMQFFKDQTI-------NHQILAGKRTYDSFG---RPLPKRKNLVLTHFQADFP-AGVKVFKTIDEFLQY
-AKGYPN---EVIFVVGGTSVFKELLPY--VDYLYRTSINHENGDVRMIDI-DYSQFELEQQIPG----------------------
>tr|A0A059WUG3|A0A059WUG3_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---MIIGIAAVSQNNAIGKGGKLPWHY-SADMKFFRETTT-------GHAVVMGRKTWLTL----GPLKNRLNIVLTRDSIEPQ-ESLLVLNDVDSVLSF
S--KSLT---TDLFVIGGAQVYREFLPF--IERWLITEVPLIKGADAFMPEGFLDDFEAKSKKKL----------------------
>tr|A0A059XEP0|A0A059XEP0_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVSKNNAIGKQGKLPWHY-SADMKFFRETTT-------GHAVVMGRKTWVSL----GPLKNRLNIVLSRDNIEPQ-ESLVVLRDLDSVLSL
N--SSLQ---TDLFVIGGAQIYTEFLPH--IERWHVTEVPIDEGADAFMPLHYLEGFKRVATKKL----------------------
>tr|A0A059WHF8|A0A059WHF8_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIAAVDRKGAIGKGGKLPWHY-SADMKFFRETTS-------GHAVVMGRKTWLTI----GPLKNRLNIVLSRDDIGPQ-DSLIVFSDMESVLSF
N--KSLS---TDLFVIGGAQIYEAFREH--IEKWIITEVPLTQGADAFMPKGYLEGFEVVESKSL----------------------
>tr|A0A059WSH9|A0A059WSH9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIAAVDRKGAIGKGGKLPWHY-SADMKFFRETTT-------GNAVVMGRKTWLTI----GPLKNRLNIVLSRDTIEPQ-ESLLVLSDIDSVLSF
N--QSLT---TDLYVIGGAQIYKAFLPH--IEQWIITEVPLTQGADAFMPGGYLDEFEVADTKPL----------------------
>tr|A0A059X1J9|A0A059X1J9_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIAAVDKQGAIGKGGKLPWHY-SSDMKFFRETTT-------GNAVVMGRRTWSTL----NPLKNRLNIVLSRDNIEPA-ESLLVLRDLDSVLSF
N--QSLT---TDLFVIGGAQIYNAFLPH--IERWFITAVPLTKGADTFMPENYLKGFKRYKKQRL----------------------
>tr|A0A059WM50|A0A059WM50_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---MIIGIVAVDRNLAIGKGGKLPWHY-SADMKFFKQTTM-------GNAVVMGRRTWSTL----KPLPNRQNIVLTRNDMTVP-AGVNAMNDADGVLSL
T--ETLN---THLFVIGGATIYKAFLPH--IDRWIVTEVPLSAEADTFMPANFLDGFEMYEMLEL----------------------
>tr|A0A059WN40|A0A059WN40_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVDQNGAIGKEGGLPWHY-SADMKFFKQQTM-------GHACVMGYRTWRSL----KPLKDRLNIVLSRKEVEPQ-PSVVVVRDILSVLSL
K--DYLS---CDLFVIGGEQVYRSFLPH--VDKWMVTEIPLAEGTDTFIPGDYLRGFKLSGSQQL----------------------
>tr|A0A059WT18|A0A059WT18_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVDQNGAIGKNGSIPWHY-SADVKFFRQQTI-------GHACVMGYTTWLSL----KPLKERLNIVLSRKEIKPQ-PSVIVLKDMLSVLSL
K--KFLA---CDLFVIGGERVYRSFLPH--IDRWIVTQIPLAEGADTFMPEGYLQEFAPYDSQQL----------------------
>tr|A0A059WWN5|A0A059WWN5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVDKNGAIGKNGSIPWHY-SADVKFFKQQTI-------GHACVMGYKTWLSL----KPLKERLNIVLSRKEVKPQ-PNVIVLRDTLSILSL
K--KFLA---CDLFIIGGEQVYRSFLPH--MDRWIVTQIPVAEGADTFMPEGYLKNFSPYDSQQL----------------------
>tr|A0A059WZE2|A0A059WZE2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIAIVAVDKNLAIGKGGVIPWHY-SADMKFFRRQTT-------GHACVMGYRTWESL----GPLKGRLNIVLSRKTVDGQ-PEVIHFTDINSVLSL
A--EYLR---CDLYVIGGAQIYKAFSER--IDRWLVTEVPEPEGADTFLNADFLSGFTANGVEVL----------------------
>tr|A0A059WMM2|A0A059WMM2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVDKNNAIGKGGQLPWHY-SSDMKFFRGQTM-------GHACVMGYKTWRTL----KPLPGRLNLVLSRREITPQ-ASVVVMRDKLDVLSL
L--PFHS---CDLFIIGGRQIYDAFLGE--IDRWLVTEVPLVDGADTFMPANFLEGFDVTQTLPL----------------------
>tr|A0A059WWU3|A0A059WWU3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---AIIGIVAVSRNGAIGRHGSIPWHY-SADLKFFKQQTV-------GNACVMGSKTWRSL----KPLPNRLNLVMSREQVEAD-PSVIVLRDKQAVLSL
K--PYLS---CDLFIIGGQQIYRAFAGE--IDRWIVTEIPLVEDADTFMPEDFLQGFKPYDSRQL----------------------
>tr|A0A059X7R4|A0A059X7R4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
---SITLVAAIDQALAIGREGKLLWPRRQADMDHFVSLTM-------GHTVAMGRKTYESISRKYRPLEGRDNWILTRDSTYSQ-PGCRIFHDVDEVL--
--RAYLG---RDLFIAGGGEVYRLFLPH--ATRLVITHVDTREDADTFFPELPTSNWSQRVLFRH----------------------
>tr|A0A059XCY7|A0A059XCY7_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
---MISIIVAMDLNGVIGRGGAMPWGRGKDDLAHFKKLTE-------GEMVIMGRKTFTDAI---NPLPNRVNIIVTRDAQATG-GAIIVVNSFDAAMVF
AE-ETPY---RHSFVIGGAEIYAQAIPR--VDSMFITRVDGQ-AGDVLFPHFDRQEWELFGQVVY----------------------
>tr|D0NVQ6|D0NVQ6_PHYIT Putative uncharacterized protein OS=Phytophthora infestans (strain T30-4) GN=PITG_17295 PE=3 SV=1
---PVSLIAACSVNRVIGKQGRLPWNLP-ADWAFFSTATQ-------NQVLVVGRRSFEEFD---E-IPNRHTIVVSSTQNARW-PSVQFARTLEQALQL
ANQYRNC---NRVFVGGGERLYKEAMDV--ADSCYVSRVHQYTDGDTFFPEWTEQFPNLTYSA------------------------
>tr|G4YI05|G4YI05_PHYSP Putative uncharacterized protein OS=Phytophthora sojae (strain P6497) GN=PHYSODRAFT_475266 PE=3 SV=1
---PVSLIVACSVNRVIGKQGKLPWNLP-ADWAFFSSATR-------DQVLVVGRRSFQEFD---E-IPNRHTIVVSSTEGGRW-SGVRVARTLHQALEL
VNQYRDC---SRVFIGGGQRLYQEAMDV--AESCYVSRVQREEGGDAFFPRWTTHFPTLRYST------------------------
>tr|W2QBT1|W2QBT1_PHYPN Uncharacterized protein OS=Phytophthora parasitica (strain INRA-310) GN=PPTG_11327 PE=3 SV=1
---PVSLIVACSVNRVIGKQGKLPWNLP-ADWAFFSSTTR-------NQVLVVGRRSFEEFD---E-IPNRHTIVVSSTQGARS-SGVLFAQTLEQALQI
ANQYRNC---NRVFIGGGERLYKEAMDV--ADSCYVSRVQQQADGDTFFPMWSKQFPNLMYTS------------------------
>tr|D3TND9|D3TND9_GLOMM Dihydrofolate reductase OS=Glossina morsitans morsitans PE=2 SV=1
----FNLIVAVSKNLGIGLKGGLPWK-LKSELKYFSQTTKRVLDPTKRNVVVMGRKTYFGIPPSNRPLRDRLNIVLSTTLTKSLPDEVLLQPNLEAAMKF
FENNNLKNSIETVWIIGGAGVFKDAMASERCHRLYITQIQSNFECDVFLPAIP-DDFQEVITEPEIPQGMQAENGTNFVYKVFQK--
>tr|B9H4E4|B9H4E4_POPTR Uncharacterized protein OS=Populus trichocarpa GN=POPTR_0005s25200g PE=3 SV=1
--RSYQVVVAATRDMGIGKDGKLPWR-LPCDLKFFKEITLATSDPGKQNAILMGRKTWESIPIKYRPLPGRLNVVLTRSFEIEDEENVITCGSISSALEL
LAEAPYCFSIDKVFVIGGGQILRETLNGPGCDAIHVTEIETSVECDTFIPSIDFSKFQPWYSSP-----PLVENGIRYSFVTYV---
>tr|A0A0P5LMT3|A0A0P5LMT3_9CRUS Uncharacterized protein OS=Daphnia magna PE=4 SV=1
---RLELIVACDQALGIGKDGTLPWN-LPSEFAYFLRMTQNRQGGDKVHVSIFGRANWESIAKTIGPWKDTISFILSRSMTQVLPKDVYVCSSFQEIINH
LHKPEIKERVDRVWVHGGVSVYKEALGSPHFYRLYKTVIEATYPADVFFPRVDETRLTLFTT-----LMSYKAFNAKISKCLSS---
>tr|Q5U9H6|Q5U9H6_PLAVI Dihydrofolate reductase (Fragment) OS=Plasmodium vivax GN=dhfr PE=3 SV=1
---IYAEPFSPRTFRGLGNKGTLPWK-CNSVDKYFLRMEASQGGDKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTEDVKEKVFIIDSIDDLLLL
LKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTSV-----SEVYNSKGTTLDFLVYS---
>tr|M7SVA6|M7SVA6_EUTLA Uncharacterized protein OS=Eutypa lata (strain UCR-EL1) GN=UCREL1_4541 PE=3 SV=1
----LTLVVAATRNMGIGRAGTLPWSGLKKEMAYFARVTKRPSTPPGMNAVIMGRKTWDSIPPRFRPLKGRLNIVISRSHAEPPAAQEVKVGSLEQAIEY
LRSGPAAAQTGHVFVIGGAQIYGAALELKEARRVLLTKVMSDFDCDTFFPLGSESKE-ELDAWTGVPEGIQEENGTRYEFQMWERID
>tr|G9I0D7|G9I0D7_HZNV2 Dihydrofolate reductase OS=Helicoverpa zea nudivirus 2 GN=orf111 PE=3 SV=1
----INLIVAVCENMGIGMNNSLPWH-LKREMAHFTKTTTTATH-PNKNAVIMGRLTWESIPKRFRPLPGRVNIVLTTKHRGDYDGATRV-SNFDEAIRV
VESR---GDIETAWVIGGASVYAAAMTHPNCHQIHLTAIKKYYECNVFFPKIDTTRFELISETPCT-----REGDVQYSYKVYQQ--
>tr|B8BYC4|B8BYC4_THAPS Uncharacterized protein OS=Thalassiosira pseudonana GN=THAPSDRAFT_261857 PE=3 SV=1
---SFGIVAALTKNGVIGINGSLPWESLTQDRDHFINLTR-------GKVLILGRKTFVDEDPSGHVDHARACIVVSSTM-YYSRSTLKVARSLDEALVM
ANKTSTRNSSIDCWVAGGERLYKDALQHPCAAEVHLTQVDITISEVAYFPVDYLNNYGF--------QEVSKREDGICVFCVYKRQ-
>tr|A0A0D6JP79|A0A0D6JP79_9EURY Dihydrofolate reductase type 3 OS=Haloferax sp. Arc-Hr GN=dhfrIII PE=3 SV=1
---RFVLVAAVADNRVIGRDGDMPW-HLPEDLKHFKRTTT-------GHPVVMGRTTYESIARQLGPLPDRHSVVLTTRDLDLPE--GEAVDSVDSAVAA
AEAAEM--GVETVYVVGGATVYEQFLD--RAAGLILTELDAAHEGDTRFPERD--REEW--------VETARDDRDGFSFVTYERR-
>tr|M0I892|M0I892_9EURY Dihydrofolate reductase OS=Haloferax mucosum ATCC BAA-1512 GN=C440_11966 PE=3 SV=1
---QFALVAAVAENGVIGRDGDMPW-HLPADLQHFKETTM-------GHPVVMGRTTYESIARQVGPLPGRQNIVLTSQDLDLPE--GETVGSVTEAVVT
AETTEM--GVETAYVVGGATVYEQFLD--RASRLILTELDDAYDGDTYFPDWRGDETSW--------VEAARDARDDFSFVVYERR-
>tr|M0HIM7|M0HIM7_9EURY Dihydrofolate reductase OS=Haloferax elongans ATCC BAA-1513 GN=C453_13046 PE=3 SV=1
---QFVLVAAVAANGVIGRDDDMPW-YLPEDMKHFKQTTM-------SHPVVMGRTTYESIARQIGPLPGRHSIVLTSRDIDLPD--GETVTSLDEAVAA
AEHAKM--GVETVYVVGGATVYEQFFD--RASKLVLTELDAAYEGDTHFPEWD--SEEW--------TETDRDDRDEFSFVEYERR-
>tr|I3R8M4|I3R8M4_HALMT Dihydrofolate reductase OS=Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) GN=
---RFVLVAAVAENRVIGRDGDMPW-HLPEDLKHFKATTM-------GHPVVMGRTTYESIARQIGPLPGRRNIVLTSRDLDLPA--GETVDSVDEAVTA
AEADDM--GVETVYVVGGATVYEQFLD--RASGLILTELDEAYEGDTYFPEWRGDETSW--------FEVDRDDRDGFSFVEYERR-
>sp|Q9UWQ4|DYRB_HALVO Dihydrofolate reductase HdrB OS=Haloferax volcanii GN=hdrB PE=1 SV=1
---RFVLVAAVADNRVIGRDGTMPW-HLPEDLKQFKRTTT-------GHPVVMGRKTYESIARQLGPLPERHSVLLTTRDLDLPE--GEAVESVESAVAA
AEDDEM--GVETVYVVGGATVYEQFLG--RAAGLVLTELDAAHEGDTRFPEWD--RGKW--------VETDRDDRDGFSFVTYERK-
>tr|V5A6C9|V5A6C9_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HR60 GN=A07HR60_02265 PE=3 SV=1
---EIAMIAAVAQNGVIGNNGDIPW-YYPADLDHFKQVTT-------GHPVIMGRRTYDGIVDGLGPLPDRTSVVLSRSALSLPA--GVHADGVETAVET
AATAAR--DVDTIYVAGGESVYELFLG--QADRLVLTEVHQEYEGDTRFPAFD--QGDW--------TETTREDHEEFSFVTYERR-
>tr|L0AKQ2|L0AKQ2_NATGS Dihydrofolate reductase OS=Natronobacterium gregoryi (strain ATCC 43098 / CCM 3738 / NCIMB 2189 / SP2) GN=Natgr_3360 PE=3 SV=1
---ELVGIAAVADNGVIGVDGEMPW-HLPEDLQHFKETTM-------DHPVIMGRVTYEGILEALEPLPGRTTIVLTSQDLETPE--NVVANDLEDALEK
AKTRERHD-ADRVFVAGGATVYEQFLL--ALDRLIVTEIHDDPDGDARFPEWD--RDAF--------REATRDDRDGFAFVEYERI-
>tr|E4NT34|E4NT34_HALBP Dihydrofolate reductase OS=Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3) GN=Hbor_14470 PE=3 SV
---EYVLVAAVAENGVIGRDGRMPW-HFSEDMAHFKQTTM-------GHPVILGRKTYENIVDAIEPFPGRMSIVLSSRELDLPE--GVLANSIKEATER
AESEEM--GVETVYVVGGARVYAQFLP--RATRMILTEIHDSYDGETEFPEWE--EAMW--------IETDRDERESFDFVTYERV-
>tr|F8D5Z2|F8D5Z2_HALXS Dihydrofolate reductase OS=Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6) GN=Halxa_3107 PE=3 SV=1
---ELVGIVAVADNGVIGKDGDMPW-HIPADLQHFKETTM-------DCPVIMGRVTYEGILEALEPLPGRTTVVLTSRDLETPE--NVVANDLAEAVEA
AETRERHDGADRAFVAGGATVYEQFLP--ALDRLIVTEVHDAPDGDTVFPDWD--RDAW--------TETDRDEHDGFAFVEYVRE-
>tr|L9XBN4|L9XBN4_9EURY Dihydrofolate reductase OS=Natronococcus amylolyticus DSM 10524 GN=C491_09444 PE=3 SV=1
---ELAAIVAVADNGVIGRDGEMPW-HLPADLEHFKQTTM-------DHPVIMGRVTYEGILEALEPLPGRTTVVLTSRELETPE--NVVANDLETALEE
AEREVRHDGADTAFVAGGATVYEQFLP--VLDRLIVTEIHDAPDGDTEFPDWE--RDEW--------TEVDRDERDGFAFVEYVCE-
>tr|L9WJW8|L9WJW8_9EURY Dihydrofolate reductase OS=Natronorubrum bangense JCM 10635 GN=C494_07065 PE=3 SV=1
---ELVGIVAVADNDVIGKDDEMPW-HIPADLQHFKETTM-------DHPVIMGRVTYEGILEALEPLPGRTTIVLTSRDLETPE--NIVANSLEGALEA
ADRSERHDDTDRVFVAGGATIYEQFLP--ALDRLIVTEVHEEPDGDTVFPDWD--RESF--------RAVSRDERDGFAFVEYARH-
>tr|M0AQP1|M0AQP1_NATA1 Dihydrofolate reductase OS=Natrialba asiatica (strain ATCC 700177 / DSM 12278 / JCM 9576 / FERM P-10747 / NBRC 102637 / 172P1) 
---ELVGIVAVADNGVIGKDGDMPW-HIPEDLQHFKAVTM-------DHPVIMGRVTYEGIVDTLEPLPGRTTIVLTSRDLETPA--NVVAHGIEAAIAT
AETDERHGGTDRLFVAGGATVYEQFLP--ELDRVIVTEVHAEPDGDARLPDWN--RESF--------RAVSRDEHDEFTFVEYVRR-
>tr|L0JZS5|L0JZS5_9EURY Dihydrofolate reductase OS=Natronococcus occultus SP4 GN=Natoc_1551 PE=3 SV=1
---ELAGIVAVADNGVIGRDGEMPW-HIPADLQHFKEATM-------DHPVIMGRVTYEGILEALEPLPGRTTVVLTSRALETPE--DVLARDLEDALET
AEREERHDGGDTAFVAGGATVYEQFLP--VLDRLIVTEIHDAPDGDTEFPDWD--RDDW--------TEVERDERDGFAFVEYVRE-
>tr|L9Y664|L9Y664_9EURY Dihydrofolate reductase OS=Natrinema versiforme JCM 10478 GN=C489_04486 PE=3 SV=1
---DLVAIAAVADNGVIGADGDMPW-HVPADLQHFKETTT-------DHPVIMGRVTYEGILETLEPLPGRTTVVLTNQDLETPE--GVVAHDLEDAVDA
AETRERHEDADRIFVAGGATVYEQFLP--AVDRLVLTEIHDAHEGDTYFPDWD--RDAF--------DEASRDERDGFAFVEYVRE-
>tr|L9VMR3|L9VMR3_9EURY Dihydrofolate reductase OS=Natronorubrum tibetense GA33 GN=C496_17542 PE=3 SV=1
---ELVGIVAVAENGVIGKDGDMPW-HIPADLQHFKKTTM-------DHPVIMGRVTYEGILEVLEPLPGRTTIVLTSRDLETPE--NVVAGSLEEALEK
ADARERHDDADRLFVAGGATVYEQFLP--ALDRLVVTEIHDDPDGDTRFPDWD--RDAF--------ETVSRDERDGFGFLEYARR-
>tr|M0CNA8|M0CNA8_9EURY Dihydrofolate reductase OS=Haloterrigena limicola JCM 13563 GN=C476_03863 PE=3 SV=1
---ELVAIVAVADNGVIGKDGDMPW-HIPADLKHFKATTM-------DHPVIMGRVTYEGILEALEPLPGRTTIVLTSRDLETPA--NVAAHDLADALET
AEAQERHGDADRIFVAGGATVYEQFLP--AVDRLIVTEVHDDPDGDTYFPDWD--RNSF--------REVSRDERDGFAFVEYTRR-
>tr|L9YNU8|L9YNU8_9EURY Dihydrofolate reductase OS=Natrinema pallidum DSM 3751 GN=C487_15494 PE=3 SV=1
---ELVGIVAVADNDVIGRDGDMPW-HVPADLQHFKETTM-------NHPVIMGRVTYEGILETLEPLPGRTTVVLTSRDLETPD--NVVANGLEEAVDR
ADTQERHGDADRIFIAGGATVYEGFFP--VLDRLVVTEVHDEPDGDTFFPAWD--RGSW--------REASRDEHDGFAFVEYVRE-
>tr|M0AD92|M0AD92_9EURY Dihydrofolate reductase OS=Natrialba chahannaoensis JCM 10990 GN=C482_16818 PE=3 SV=1
---ELVGIVAVADNGVIGKDGDMPW-HIPADLQHFKETTM-------DHPIIMGRVTYEGILETLEPLPGRTTVVLTSQTLETPE--NVLAKDLEVALKA
ADERDRHDDTDQIFVAGGATVYEQFLP--ALDRLIVTEVHREPEGDTLFPDWD--RKAW--------SEEFRDDRDGFSFVEYVRD-
>tr|D3SQY4|D3SQY4_NATMM Dihydrofolate reductase OS=Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) GN=Nmag_2988 PE=3 SV=1
---ELVGIVAVADNGVIGKDGDMPW-HIPEDLQHFKETTM-------AHPVIMGRVTYESIVDALEPLPGRTTVVLTSRDLETPE--NVVAHDLQSAVEE
AAADERHDGADRVFVAGGATVYEQYLP--ALDRLIVTEVHEEPDGDTQFPDWD--RTDF--------DEVERDEHDGFAFVEYVRT-
>tr|L0JNB1|L0JNB1_NATP1 Dihydrofolate reductase OS=Natrinema pellirubrum (strain DSM 15624 / JCM 10476 / NCIMB 786) GN=Natpe_2495 PE=3 SV=1
---ELVGIVAVAENGVIGRDGDMPW-HVPADLQHFKETTM-------GHPVIMGRVTYEGILETLEPLPGRTTVVLTSRDLETPE--GVVAHDLESALER
AETRERHDDADRIFVAGGATVYEQFLP--ALDRLIVTEIHDDPEGDTSFPEWD--RSEW--------DVVSRDDRDGFAFLEYVRR-
>tr|L9ZRV8|L9ZRV8_9EURY Dihydrofolate reductase OS=Natrinema altunense JCM 12890 GN=C485_05026 PE=3 SV=1
---ELVGIVAVADNGVIGRDGDMPW-HIPDDLQHFKEATM-------DHPVVMGRVTYEGILETLEPLPGRTTVVVTSRDLETPD--NVIANGLEEAVDR
ADTRECHDDADRIFIAGGATVYEGFLP--ALDRLVVTEVHDEPDGDTFFPGWE--RASW--------TEASRDERDGFAFVEYVRE-
>tr|M0LFN9|M0LFN9_9EURY Dihydrofolate reductase OS=Halobiforma lacisalsi AJ5 GN=C445_15901 PE=3 SV=1
---ELVGIVAVADNGVIGADGEMPW-HLPADLAHFKETTM-------DHPVIMGRVTYEGILETLDPLPGRTTVVLTSQDLETPE--NVVANGLTEAVER
ADRRERHDGADRIFVAGGATVYEGFLP--VLDRLVVTEIHDDPEGDAYFPAID--PEDW--------IEADRDERDGFAFVEYVRR-
>tr|M0LNU2|M0LNU2_9EURY Dihydrofolate reductase OS=Halobiforma nitratireducens JCM 10879 GN=C446_13139 PE=3 SV=1
---ELAGIVAVADNGVIGADGELPW-HLPEDLAHFKEITM-------DHPVIMGRVTYEGILETLEPLPGRTTVVLTSRDLETPE--NVVASTLEDALER
ADRRERHDGADRIFVAGGATVYEQFMP--ALDRLVVTEVHDDPEGDAFFPDLE--SADW--------IETDRDERDGFAFVEYVRR-
>tr|G0LJ08|G0LJ08_HALWC Dihydrofolate reductase OS=Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23) GN=folA1 PE=4 SV=1
---DIVLIAAVAANDIIGRDGEMPW-HIPADLQQFKRRTM-------GHPVILGRRTYEAIIGALEPFPGRTSIVLSSQSRDVPA--DILVHSITSAIRE
ASKRER--GVGTVYVAGGGGVYEQFLP--LADRLRLTELHDEYEGDTKFPSWD--DTVW--------QETTREKNETFDFVTYERT-
>tr|U1PQN4|U1PQN4_9EURY Dihydrofolate reductase OS=Haloquadratum walsbyi J07HQW2 GN=J07HQW2_01083 PE=3 SV=1
---DIELIAAVAANGVIGRDGGMPW-HIPADLQQFKQRTM-------DHPVILGRRTYEAIVDALEPFPGRTSIVLSSQSRDMPP--GILTHSIQSAIHE
ASERER--GVRTVYIAGGGGVYEQFLS--VADRLRLTELHEEYDGDTRFPSWD--HNTW--------KEVTRESHEKFDFVTYERS-
>tr|U1N751|U1N751_9EURY Dihydrofolate reductase OS=Haloquadratum walsbyi J07HQW1 GN=J07HQW1_02334 PE=3 SV=1
---DIVLIAAVAANGVIGRDGEMPW-HIPADLQQFKHRTM-------GHPVILGRRTYETIIDALEPFPGRTSIVLSSQSRDVPT--DILVHSITSAIRE
ASKHER--GVETVYVAGGGGVYEQFLP--LADRLRLTELHDEYDGDTRFPSWD--SSTW--------KELTRENHETFDFVTYTRT-
>tr|H5UNR1|H5UNR1_9MICO Dihydrofolate reductase OS=Mobilicoccus pelagius NBRC 104925 GN=folA PE=3 SV=1
---ELVLVALVAANGVIGDGEDQPF-RFREDFARFKALTT-------GHPLLMGRRTHEAI----RALPGRRTIVLTRDR-QWRDVAH----DLDEALAL
AED---LPGGEEVMVLGGGEIYRATID--RAHRLELTEVDAPARGDITFPEID--PAQW--------REVARDDRAAFAFVTYARG-
>tr|L0ICV9|L0ICV9_HALRX Dihydrofolate reductase OS=Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70) GN=Halru_1456 PE=3 SV=1
---ELVAIVAVAENGVIGVDGEMPW-HIPEDLAHFKRETT-------GHPVIMGRVTYESIVAGLEPLPDRTSIVLTSRAFETPE--NLVVDGIDAAVRA
AERRERHDGSGRTYVAGGASVYEQLLP--AVDRLVVTEVGRAPEGDAFFPEID--PSVW--------REVARDERESVTFLEYERI-
>tr|M1XKY7|M1XKY7_NATM8 Dihydrofolate reductase OS=Natronomonas moolapensis (strain DSM 18674 / JCM 14361 / 8.8.11) GN=folA1 PE=3 SV=1
---KVALVAAVAENGVIGSDGEMPW-HYPADLRKFKETTM-------GHPVVMGRKTYESIADRLGPLPGRTNVVLSRRDSCLPE--GVHARDLDAAFEA
AETLAS--GQETAYVVGGATVYEACLD--RADELVVTEIPEAPAGDTHFPEIG---HEW--------TEHGRERVGDVSVVTYRRT-
>tr|U1PZ51|U1PZ51_9EURY Dihydrofolate reductase OS=Haloquadratum sp. J07HQX50 GN=J07HQX50_01835 PE=4 SV=1
---QTVLIAAIARNGIIGRGGSMPW-HLPADLSHFKQLTV-------GHPVIIGRKTYESVLDALKPFPNRTTVVLTSQSLSVPD--GVVAHSIDDALER
ARSERR--GVNRVYVAGGGNVYAQFLD--DADVLELTELEDAYEGDTAFPTFD--TEKW--------AETARETHEKYDFVTYERV-
>tr|M0E3A5|M0E3A5_9EURY Dihydrofolate reductase region OS=Halorubrum saccharovorum DSM 1137 GN=C471_04495 PE=3 SV=1
---DLVLVAAVAENRVIGDSGGMPW-HYPADLAHFKRLTT-------GHPVIVGRATYESIADRIGPLPDRTSVVLTTRDLDLPE--GVVANDVEEAIDL
ADAADR--GVDEAYVIGGATVYEQFLD--RADRMVLTEVPGRPDGDTRFPEWD--AEAW--------DERDRETDGDLAFVTYERR-
>tr|M0D2Z7|M0D2Z7_9EURY Dihydrofolate reductase region OS=Halosimplex carlsbadense 2-9-1 GN=C475_03389 PE=3 SV=1
---EIALIAAVAENRVIGHEGEMPW-HYPADLAHFKETTT-------GHPVIMGRVTYESISGQLGPLPGRTNIVLTRSGVEAPE--KVQVESADAAVEA
AEAAET--GAETAFVAGGATVYEAFLD--RADRLVLTEVPGEPEGDTRFPEWD--SAEW--------VEADREREGELSFVTYERR-
>tr|V4XZM1|V4XZM1_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HR67 GN=A07HR67_01073 PE=3 SV=1
---DIVLVAAVAENGVIGADGEMPW-HYPRDLAHFKRLTT-------GHPVVLGRITYESIAERIGPLPDRPSVVVTTGDPELPD--GVAAGGIKEATER
ARAADR--GVDAIYVIGGATVYEAFLP--VADRMVLTEVPDRPDGDTRFPAWD--AEAW--------TETDRETDGDLAFVTYERV-
>tr|M0EF41|M0EF41_9EURY Dihydrofolate reductase region OS=Halorubrum californiensis DSM 19288 GN=C463_06137 PE=3 SV=1
---VLVLVAAVAENGVIGGDDRMPW-HYPADLAHFKRLTT-------GHPVIVGRKTYEGIADRIGPLPDRTSVVLTTRQIDLPD--GVVAGGVEEALDR
AAAAER--GVDAVYVIGGATVYEAYVE--RADRMVITEIPERPAGDTRFPEWD--ADAW--------TERERETDGDLAFVTYERR-
>tr|V6DYI5|V6DYI5_9EURY Dihydrofolate reductase region OS=Halorubrum sp. AJ67 GN=C467_07195 PE=3 SV=1
---DLVLVAAVAENGVIGDDDGMPW-HYPADLAHFKRLTT-------AHPVIVGRKTYEGIRDRLGPLPDRTSVVMTTRSIDLSD--GVVAHDLDEAVSR
ATAADR--GVDAVYVIGGATVYEQFLD--RADQLVITEIPERPGGDARFPEWD--AEEW--------AETDRERADDLAFVTYERR-
>tr|M0PBV6|M0PBV6_9EURY Dihydrofolate reductase region OS=Halorubrum aidingense JCM 13560 GN=C461_09582 PE=3 SV=1
---DIVLVAAVAENRVIGDDGGMPW-HYPADLAHFKRLTT-------GHPVIVGRATYESIADRIGPLPDRTSVVLTTRDPDLPE--GAVANDVEEAVAR
ATATDR--GVDAVFVIGGATVYEQFLD--RADRMVLTEVPGRPDGDTRFPAWD--DEEW--------IETDREADGEISFVTYERV-
>tr|M0PI41|M0PI41_9EURY Dihydrofolate reductase region OS=Halorubrum arcis JCM 13916 GN=C462_14188 PE=3 SV=1
---DLVLVAAVAENGVIGDGGGMPW-HYPADLAHFKRLTT-------GHPVIVGRKTYERIADRIGPLPDRTSVVLTTRPIDLPE--GVVAHDVESARSR
ANAAAR--GVDVVYVIGGATVYEAYLE--RADRMVLTEIPERPEGDTRFPEWD--PEAW--------AERDREADGDLAFVTYERR-
>tr|M0FB66|M0FB66_9EURY Dihydrofolate reductase region OS=Halorubrum hochstenium ATCC 700873 GN=C467_07195 PE=3 SV=1
---DLVLVAAVAENGVIGGDDGMPW-HYPADLAHFKRLTT-------GHPVIVGRTTYEGIADRIGPLPDRTSVVVTTRPIDLPD--GVVAGDLDEALAR
ATAADR--GVDAVYVIGGATVYEQFLD--AADRMVITEIPERPDGDVRFPEWD--AEAW--------AETDRETEGDLAFVTYERR-
>tr|A0A081EV11|A0A081EV11_9EURY Dihydrofolate reductase OS=Halorubrum saccharovorum GN=FK85_04720 PE=3 SV=2
---DLVLVAAVAENRVIGDRGGMPW-HYPADLAHFKRLTT-------GHPVIVGRATYESIVDRIGPLPDRTSVVLTTRDLDLPE--GVVANDIEEAVDL
AAAADR--GVDEVYVIGGATVYEGFLD--RADRLVLTEIPERPDGDTRFPDWD--PGEW--------TEVEREDDDGLAFVTYERV-
>tr|V4XXC7|V4XXC7_9ARCH Dihydrofolate reductase OS=uncultured archaeon A07HB70 GN=A07HB70_00897 PE=3 SV=1
---RVVLVAAVAANGVIGADGEMPW-HLPADLEHFRELTL-------GHPVVVGRRTHEAVRASLGPLPDRTNVVLTTTPEALPD--DVAVGSVRAALDA
A--AAT--GAATAYVAGGASVYEQFLP--HADTMVLSELDESFAGDTRFPAVD--RERW--------RETSRERYDQFDVVTYSRD-
>tr|M0NKG8|M0NKG8_9EURY Dihydrofolate reductase region OS=Halorubrum lipolyticum DSM 21995 GN=C469_14047 PE=3 SV=1
---DLVLVAAVAENGVIGDSGGMPW-HYPADLAHFKRLTT-------GHPVIVGRATYESIAARLGPLPDRTSVVLTTRDLDLPE--GVVANGVEEAVDL
AAAADR--GVDEAYVIGGATVYEQFLD--RTDRMVLTEVPERPDGDTRFPDWD--AAEW--------SETEREDDGDLAFVTYERT-
>tr|M0ENE6|M0ENE6_9EURY Dihydrofolate reductase region OS=Halorubrum coriense DSM 10284 GN=C464_04938 PE=3 SV=1
---DLVLVAAVAENGVIGGDDGMPW-HYPADLAHFKRLTT-------GHPVIVGRKTYEGIADRLGPLPDRTSVVLTTRSLDLPD--GVVAGGVEAAVSR
AAAARR--GVETVYVIGGATVYEAFLD--RADGMVLTEIPERPAGDTRFPEWD--ADAW--------VERGRETDGDLAFVTYDRR-
>tr|A0A0N0BRG2|A0A0N0BRG2_9EURY Dihydrofolate reductase OS=Halorubrum sp. 5 GN=AMR74_05120 PE=3 SV=1
---DVVLVAAVADNGVIGDGGGMPW-HYPADLAHFKRLTT-------GHPVIVGRKTYERIAERIGPLPDRTNVVLTTRSIDLAD--GVVAHDVESALSR
ATAAER--GVDAVYVIGGATVYAAYLD--RADRMVITEIPERPAGDTRFPEWD--ADAW--------AERDRETDGDLAFVTYERC-
>tr|B9LR90|B9LR90_HALLT Dihydrofolate reductase region OS=Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) GN=Hlac_2167 PE=
---DLVLVAAVAENRVIGDDGGMPW-HYPADLARFKRLTT-------GHPVIVGRATYESIADRIGPLPDRTSVVLTTRDLDLPE--GVVANDLDEAVDL
AGAADR--GVDDVYVIGGATVYEQFLD--RADRMVLTEVPEQPDGDTRFPDWD--DEEW--------VETEREEADALAFVTYERV-
>tr|A0A0G1LCD7|A0A0G1LCD7_9BACT Dihydrofolate reductase OS=Parcubacteria bacterium GW2011_GWA2_45_14 GN=UW94_C0005G0036 PE=3 SV=1
---KIHLIVAITAQGVIGNKKGLPW-HIPEDLKQFKKITS-------GNTILMGRRTYETI----RPLPNKENLVLDAEK-KPI--AGTVCGSIDEALTW
AEK-----QGKELYVIGGASVYAQMLP--MVEVMHISHVKKDYPGDVYFPEYD--KSKW--------QEIKREEYDEFTAITYRRN-
>tr|A0A059X474|A0A059X474_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
---HFKAIAAMSLNRVIGAGNKIPW-HLPEDFKWFKQLTT-------GNVVVMGRKTFESI----RPLPNRETIILSRSQFAYPG---RTISDLGQ-IEL
------AHEAREVFICGGAQVYAQALP--LCSDLYLTRVKREVEGDAFFPAFE---FEL--------AEELRD-TPDFKILHYRQM-
>tr|U2QM96|U2QM96_9ACTN Dihydrofolate reductase OS=Propionibacterium acidifaciens F0233 GN=folA PE=4 SV=1
---RVIAIALVAANGVIGDGVDQPF-RFREDWRRFKATTF-------GHPLILGHATHRTM----L-LAGRTSIVISRDPARFPEGARIAVASLDEALDV
AAG---LD-REKVFICGGGEVYRAAMG--RVDELDITAVHADAAGAVTFPPID--PARW--------RETERIVGERFDVVRYERI-
>tr|A0A0A8PGF6|A0A0A8PGF6_9ACTN Dihydrofolate reductase OS=Propionibacterium freudenreichii GN=folA (folA2) PE=4 SV=1
---GVVAIAVVATNGVIGDGHDQPF-KFPEDWARFKRVTL-------GHPLITGRRTHDAM----L-LTGRTNIVVSRTPQTWPDGSHIAVSSIEEALAV
ASG---LD-Q-RIYVIGGGQIYKAAWD--WLTDLDITAVHEPADGSVTFPEIS--AQDW--------SQTSSEPHGEFDFVHYARI-
>tr|R7EZU9|R7EZU9_9BACT Dihydrofolate reductase OS=Prevotella sp. CAG:485 GN=BN677_01435 PE=4 SV=1
---QLSVIVAADMRGAIGLRGGMLW-HLRDDLRRFKAITT-------GKAVIMGRKTWQSLPR--RPLPGRLNVVITRQSDFVAE--GRVAGSLTEAIGI
AA------GCEEIFIIGGGEIYRQALG--MATRLYMTRIAEAPEADTFFPEVS--ADEW--------TLTEQEETPAFRFENYVRT-
>tr|U5NC46|U5NC46_9BURK Dihydrofolate reductase OS=Candidatus Symbiobacter mobilis CR GN=folA PE=3 SV=1
---HCHLILARARNGVIGRHGALPW-HLPQDLAHFRRTTW-------GAHVLMGRTTWEGLPERYRPLPGRQNVVLTRQA-DWQA-PGLVAHSLEEALAL
GAD------DGIAWVIGGAQTYALALP--LAEEAVITEIDADYDGDAYAPEFD--PAQW--------VEVSRDAH-RFALVRWGRL-
>tr|E5ANT5|E5ANT5_BURRH Dihydrofolate reductase (EC 1.5.1.3) OS=Burkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454) GN=RBRH_01754 PE=3 S
---TLYLIVARARNGVIGRDNALPW-RLPEDLAHFKRTTM-------GAPLIMGRKTHESI----RALPGRRNIVVTHDAT-F----GDTVTSLDAALAL
CET---LH-APLAYLIGGAQLYREGIG--RAGRLIVTEIDHAFEGDATFAAPS--PEHW--------REVSRETHRDYAFVEYERI-
>tr|A0A0B5JAM3|A0A0B5JAM3_9VIRU Dihydrofolate reductase OS=Pandoravirus inopinatum PE=3 SV=1
---LFSVVVAMTASRAIGQQGQLPWGRLPKEMAAFRDLTRTTVDPTKTNALIMGRVTFDSLPRR-RPLPGRLHVVLTRRPPVYPD--GLTAPGLDEALAL
VGH------AEKVFVIGGAQVYKDAIAHPACAGVWLTQIPDYPDADAFFPALS---EAY--------GPVETLDESCECGVTYQRL-
>tr|S4VSZ4|S4VSZ4_9VIRU Dihydrofolate reductase OS=Pandoravirus dulcis GN=pd_654 PE=3 SV=1
---SFAVVVAMTASRAIGQQGQLPWGRLPKEMAAFRDLTRTTVDPAKTNALIMGRATFDSLPRR-RPLPGRLHVVLTRRPAAYPE--GLTASGLDEALAL
TAH------AEKIFVIGGAQVYNEAVDHPACAGIWLTQIPDYPDADAFFPPLS---KAY--------GGAEALDEPRECGVAYQRL-
>tr|K2AM63|K2AM63_9BACT Thymidylate synthase OS=uncultured bacterium (gcode 4) GN=thyA PE=3 SV=1
--PRISMIAAIDKEMGIGKAGKIPWH-IPEDMKWFKEKTLG-------HVVIMGKNTFTSLG---KPLPGRTNIVVSDTKLVAPK-GVFVVNSLGTAISL
AEKK---EKNGEIFFIGGGQLYASALRY--TSRLYLTQLVGAFGADTFFPNYKSFTKLVFSKKGR-------SADYKYEFRILEK--
>tr|A0A059X6L9|A0A059X6L9_9BACT Thymidylate synthase OS=uncultured bacterium PE=4 SV=1
--GRVTIVVAIGQNGVIGADGDMPWP-RTGDQVQFKALTMG-------HPMIMGRTTYESIG---RPLPGRTSIVLTRNPSWAAE-GVEVAGDLPAGLAR
AAEL-----DDEVFLIGGAQVYAAAIEAGVVDRMVVTHVHLSPEGDAWFPDVDWTAWHETSREKYDT---YD-------IATYDR--
>tr|A0A059X8W9|A0A059X8W9_9BACT Thymidylate synthase OS=uncultured bacterium GN=thyA PE=3 SV=1
--LIVSLLVAMDERRGIGRRGGLPWR-LSSDLKRFRELTMG-------HHIVVGRKTFEAIG---KPLAGRQMIIVTRDPDYHIA-GCFTVHSIAEALEL
ARQH----GETELFICGGAEIYARTMEL--AERLYLTRVHADCDADTFFPEFNPEDWLETASETHAA---DEKNQHPFTFSLLER--
>tr|V7EIL0|V7EIL0_9RHOB Thymidylate synthase OS=Rhodobacter sp. CACIA14H1 GN=thyA PE=3 SV=1
--GMITLIVARARNGAIGKGNTIPWH-APEDLAAFQRETTG-------GAVIMGRRTWESLPF--KPLKNRLNIVVSRDAAVWET----VAPTPEAAVQM
AQAA----GHARIYGIGGSSVYAALMPL--AHRLLVTEVDMDVDADAFFPAFDEGAWRVIWERRLRE---DGPGCV---LREWVR--
>tr|A0A0G0YFG6|A0A0G0YFG6_9BACT Thymidylate synthase OS=Parcubacteria (Magasanikbacteria) bacterium GW2011_GWC2_41_17 GN=thyA PE=3 SV=1
--TILLMAVTVDGKIAKTTDHLANWT-SKADKKIFVEETKKA------GVIVMGETTYKTIG---RPLPGRLNVIMSHTPDASQQPGILEFTTPPRELLR
DLVD---RGFNAVILGGGATINGLFLQEGLIDEVWLTIEPKIFGGLSLFKGADVNLDLEMIETRQLD---ANVIQVRYKVKK-----
>tr|A0A059XAW5|A0A059XAW5_9BACT Thymidylate synthase OS=uncultured bacterium GN=thyA PE=3 SV=1
--MKFELVVAADEARGIGRAGGLPWR-LPGDMAFFKRVTSEAPA-GRHNAVLMGRKTYASISPKFRPLRGRLNVVLSRQAALTVE-GVLVFGSLEAALAR
LAAF---TDLAHTFVIGGGELYAEAIAHPGLARVHLTRVHATFDCDTCLAPFEDRFRLVTQDGPHH------DDGVHYTFETYER--
>tr|I6T9L7|I6T9L7_ENTHA Thymidylate synthase OS=Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 
--EMLAAIWAQDENGLIGKEDQLPWR-LPNDLKFFKQMTEA-------NTLVMGRKTFEGMGS--RPLPNRQTIVMTRDRDYQAD-NVMVMHEIEEVLDY
AKEN-----DGILFVAGGSAIYKEFLPF--CSVLYRTVIHHSFIGDTYFPEVDWDQWSLINISQGEM---DEKNPYAHQFETYQR--
>tr|K0YRR1|K0YRR1_9ACTO Uncharacterized protein OS=Actinomyces neuii BVS029A5 GN=HMPREF9240_01551 PE=4 SV=1
------MIWAQDRNGILGAGGNMLWH-VPADFKHFKATTMSH-------PIVMGRKSWQSIGS--RPLPGRTNIVITSNPSFEAGGA-IVCPSLQAALHK
ARQ---CPGGEQIWITGGGQVYTAALDLAE--ELVVTKLDLDVSAAVYAPRIGPE-FVLDQSRSD--SSWREAGA-RWKVEIYRR--
>tr|W1TRA9|W1TRA9_9ACTO Dihydrofolate reductase OS=Varibaculum cambriense DORA_20 GN=Q618_VCMC00001G0350 PE=3 SV=1
----IGMIWAQAAHRVIGNGQGMLWH-VPADFKHFKATTIGS-------PIIMGRRSFEALGK--RALPGRLNIVLTSKENYQASGA-KIATSIPQALAL
AQ----ATGAQKCWITGGARLYEEGMEIAD--ELVVTYLDLDVGSYAHAPTISPQLWAVDPDRSD--SQFRPIGC-RWKVIYYQK--
>tr|A0A0E9EQA1|A0A0E9EQA1_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_3 PE=3 SV=1
----IASIWAQDKNGVLGTGTSMVWH-VPADFAHFKASTLGC-------PIIMGRRSFEALG---APLPGRTNIVITRSHLYEADGI-DLVYSIEAALKR
AQDKAEADDAPYVWITGGAHLYAQTMDLVD--ELVVTDLDLDIEPLVHAPAIDPTVWAVDPQRSD--SEWNEKGA-RWKVTTYVR--
>tr|E6KV00|E6KV00_9ACTO Dihydrofolate reductase OS=Actinomyces sp. oral taxon 180 str. F0310 GN=folA PE=4 SV=1
----LAAIWAQDRGGVLGTGTSMSWR-VPADFRHFKESTMGC-------PIVMGRRSWEALG---GALPGRTNIVVTRSQRYEAPGA-HVAHSVEDALDH
ARAVAQETGAPYVWITGGAHLYAQTLPLLD--EAVISDLDLDVATFVYAPALDPSLWRRDEERSD--TDWREIGA-RWKVTTWVQ--
>tr|E8JG58|E8JG58_9ACTO Dihydrofolate reductase OS=Actinomyces sp. oral taxon 178 str. F0338 GN=folA PE=3 SV=1
----TASIWAQDRGGVLGSGGGMLWH-VPADFAHFKAATMGC-------PIIMGRHSWEALG---GPLPGRANIVITGSREYRADGA-DLVHSLDEALER
ARSHAEASGAATIWIIGGASVYEQAMPLVD--ELVVTDIDCDATPVVYAPGIDASAWDRDEERSD--AQWREPGS-RWRVTTWVR--
>tr|A0A095WR75|A0A095WR75_9ACTO Dihydrofolate reductase OS=Actinomyces sp. S6-Spd3 GN=HMPREF1627_06685 PE=3 SV=1
----LGAIWAQDCNGIIGTGTAMSWH-VPADFRHFKESTMGC-------PIIMGRRSWEALG---RALPGRTNIVITRRPGYEAEGA-LVVSSVDEALQI
AREETARTDAPYIWITGGAQLYAQTLPLLD--EAVVTDLELDVATFVYAPPLDPALWRRDEERSD--AQWRERGA-RWKVSTWVQ--
>tr|A0A0K1N766|A0A0K1N766_9ACTO Dihydrofolate reductase OS=Actinomyces meyeri GN=ADJ76_01740 PE=4 SV=1
----VAAIWAQDRGGVLGTGAAMAWR-VPADFRHFKESTMGC-------PIIMGRRSWEALG---RALPGRTNIVVTRSPGYEAVGA-HVAHSVESALAH
ARAVAEDTGAPYVWITGGANLYAQTLPLLD--EVVVTDIDLDVASLVYAPPLDPALWRRDEARSD--ANWRELGA-RWKVSTWVQ--
>tr|A0A0G3H0G4|A0A0G3H0G4_9CORY Dihydrofolate reductase OS=Corynebacterium mustelae GN=CMUST_04825 PE=4 SV=1
----LSAIWAQNETGIIGDGTAMPWH-VPEDLKHFKEKTLGS-------DVIMGRKTWESLPK--TPLPGRKNIIISRRPAGQSAGA-EVTD--------
-----TIP--TSGWIIGGGQLYAATIADVA--VIERTLIDAPLTAAVYAPDIPTD------FTCCARSEWLLSS-----FETWVR--
>tr|S3BWC0|S3BWC0_9BURK Dihydrofolate reductase OS=Sutterella wadsworthensis HGA0223 GN=HMPREF1476_01771 PE=3 SV=1
----IELIAA----AVIGAENKLLWR-IPEDFAFFKKTTMGS-------PVVMGSRTWASIG---RALPGRLNVIVSRRLQP--A-V-VVVKSLNEALSL
AQAR---SRTGRVFVIGGGEIYRRTIAIAD--RVWLTKIDHDFEGDTYFPTIPRG-------------RFRGEF--RVDFECWTK--
>tr|C0VZ67|C0VZ67_9ACTO Dihydrofolate reductase OS=Actinomyces coleocanis DSM 15436 GN=folA PE=3 SV=1
----VKMIWAQDAEGKLGSGSEMLWH-VPADFRHFKQSTVGF-------PLIMGRKSWDALGR-FAPLPQRRNIVVTRNRDFIPEGG-EVAFSIEEAISL
AS----A-DSELVWIAGGAHIYEQAMPFAD--ELVVTYLDLNVSPVVYAPQIDPAVWEVVKAESD--ADWREKGA-RWKVVVYRR--
>tr|A0A095WMU6|A0A095WMU6_9ACTO Dihydrofolate reductase OS=Actinomyces sp. S6-Spd3 GN=HMPREF1627_08360 PE=4 SV=1
----LASIWAQTADGLLGSGTEMLWR-VPADFAHFKAATMNC-------PIIMGRSSWDALG---RPLPGRTSIVITRNPDLKLDGA-LVAHSLDEAVRL
GQEDARERGSERVWITGGAQIYTQSMPLVD--ELVVSFLELDDPHHVYAPEISPEEWGLDLSRSD--EAWRPAGALRWKVEVFRR--
>tr|N6WB37|N6WB37_9ACTO Dihydrofolate reductase OS=Actinomyces cardiffensis F0333 GN=folA PE=4 SV=1
----LASIWAQDVKGVLGSGTDMLWR-VPADFAHFKKSTLGC-------PIIMGRRSWMALG---GALPGRTNIVITRSPDFEAPGA-LVAHSLGDALEL
AKRIAEAEGAHHVWITGGGDVYEQTMDLVD--ELVVTELDFDAAPLVKAPLIDEEVWGVDPKRSD--EDWQAKGA-RWRVRTYVR--
>tr|S2VRU2|S2VRU2_9ACTO Dihydrofolate reductase OS=Actinomyces europaeus ACS-120-V-Col10b GN=HMPREF9238_01583 PE=3 SV=1
----VAMIWAQDVNGVLGNGREMLWH-VPGDFKHFKAATLGH-------PVIMGRGSWEALGG--KPLPGRLNVVITGQEGYEAEGA-EVAHSLGQAVAV
AR----T-SAELVWIVGGARVYAEAMGIAD--ELVVTDLDLEVADLVYAPTIDAETWQADPERSD--AQWRTQGA-RWKVTTYVR--
>tr|A0A095WUG2|A0A095WUG2_9ACTO Dihydrofolate reductase OS=Actinomyces sp. S4-C9 GN=HMPREF1628_05680 PE=3 SV=1
----IAMIWAQDKNGVLGNGNEMLWH-VPEDFKHFKAATLGH-------PVIMGRGSWEALGG--KPLPGRLNVVITGQKDYVAEEA-KVTHSLQQAVAV
AQ----T-SAELVWIVGGARVYADAMGIAD--ELVVTDLDLEVADLVYAPTIDTESWWADPARSD--AQWRPRGA-RWRVTTYLR--
>tr|C0W934|C0W934_9ACTO Dihydrofolate reductase OS=Actinomyces urogenitalis DSM 15434 GN=folA PE=4 SV=1
----VGAVWAQDAHGVLGADGDMLWR-VPADFRHFKATTLGG-------VVIMGRTTWESIG---AALPGRASIVLTREPGWTAPDA-VVAGGLDQAVER
-AEDEAVRALPRLWVIGGGSVYAQVLAAVD--ELVISVLDLDAAQLVHAPQIDPASWHLTKSVSDPPGTWRPVGA-RWRVDHWRR--
>tr|A0A0M4GNZ7|A0A0M4GNZ7_9ACTO Dihydrofolate reductase OS=Actinomyces sp. oral taxon 414 GN=AM609_08800 PE=4 SV=1
------MIWARDHTGLLGAGGAMLWR-VPADFRHFKATTLGG-------ALIMGRVTWESIG---SALPGRRSIVLTRNRTWGAPGA-IAVGGLEEALRR
GRE-VARRGLPRMWVIGGADVYGQVLDEAE--WAVVSTLALDAS-AVRAPELDEARWRQVPTASDALGRWRPVGA-AWRVDHWAR--
>tr|F9EI15|F9EI15_9ACTO Dihydrofolate reductase OS=Actinomyces sp. oral taxon 448 str. F0400 GN=folA PE=4 SV=1
----LGMIWAQDPCGVLGASGTMLWR-VPADFRHFKAATLGG-------AVIMGRTTWESIG---GALTGRANIVLTRRDGWEADGA-VRAASLRHGLAL
GARASAYRALPRLWVIGGGSVYARTAFEAD--ELVVTTVDLDAGLLIHAPRIDDDEWMPDGALSDAPGTWRPVGA-AWRVDHYLH--
>tr|J1HMR1|J1HMR1_9ACTO Putative dihydrofolate reductase OS=Actinomyces massiliensis F0489 GN=HMPREF1318_0808 PE=4 SV=1
----LGMIWAQDVTGVLGAHGGMLWR-VPADFQHFKAMTMGC-------GLVMGRVTWDSLG---GALRGRRNVVLTRDRQWRAPGA-LSASRLNEGLSL
AARGDEAAGLPRLWVIGGGNVYAQAMAAPD--VLVVSVLGLDAAALVRAPAISTEEWRIDPERSDAPGTWRPVGA-RWRVEVWRH--
>tr|U1QTM7|U1QTM7_9ACTO Dihydrofolate reductase OS=Actinomyces johnsonii F0542 GN=HMPREF1979_00903 PE=4 SV=1
----LGMIWAQDVTGLLGADGDMLWR-VPADFAHFKATTMGC-------GLVMGRTTWESLG---GALPGRRNVVLTRDRSWQAKGA-IRAGSLREGLSV
ATRGGAAVGLPRLWVIGGGSVYRQALAEPD--VLVVSVLDLDATALVRAPGISTQEWAIDPALSDPEGQWRPVGA-RWRVETWRH--
>tr|F2V0H1|F2V0H1_ACTVI Uncharacterized protein OS=Actinomyces viscosus C505 GN=HMPREF0059_02608 PE=4 SV=1
----LGMIWAQDVTGVLGADGGMLWR-VPADFAHFKATTMGC-------GLVMGRTTWDSLG---GPLPGRRNVVLTRDRSWRAEGA-VRAGSLREGLSL
AAQGGDAAGLPRLWVIGGGRVYEQALDDPD--VLVVSVLDLDATALVRAPGISTQEWAIDPALSDPRGQWRPAGA-RWRVETWRH--
>tr|A0A0Q6FIN9|A0A0Q6FIN9_9ACTN Uncharacterized protein OS=Marmoricola sp. Leaf446 GN=ASG49_12420 PE=4 SV=1
----VVLVAA----RVIGATGGIPWR-IPADFAHFKRTTVGH-------PLVLGRATFEGIG---RPLPDRQSIVVTSDRAWAHEG--LVARSFEEALEV
GAGL-----DEVVNVGGGGRLYAEAIRFAT--EQVLTEVDLAPEGDTHYPDFDEA-------------DWVETR--DDPAWTIRW--
>tr|S3WZE9|S3WZE9_9ACTN Dihydrofolate reductase OS=Propionibacterium sp. oral taxon 192 str. F0372 GN=HMPREF1531_01768 PE=3 SV=1
----LVSIAV----VVIGDGTDQPFK-FAEDWKRFKALTMGH-------PLIMGRRTHQSMG----LLPGRFSIVITHDPASVDFPG-RAVPGIKEAIEL
AGEL----DQEVAHVVGGGQVYATTMDLVD--ELDITQVHADAEGSVLFPVIDPR-------------IWREIR--EFSFVRYRR--
>tr|A0A063ZUB7|A0A063ZUB7_9EURY Dihydrofolate reductase OS=Halostagnicola sp. A56 GN=EL22_07530 PE=3 SV=1
----LVGIVA----VVIGRDGDMPWH-IPADLEHFKETTMDH-------PVIMGRVTYGGILEAGEPLPGRTTVILTSQDLETPEN--VTAAGLEAALEA
AETA-RHDDADRIFVAGGATVYGQFLPALD--RLIVTEVHEEPTGDTTFPSWDRA-------------AWDELR--GFVFVEYGR--
>tr|L9WW05|L9WW05_9EURY Dihydrofolate reductase OS=Natronococcus jeotgali DSM 18795 GN=C492_17620 PE=3 SV=1
----LVGIVA----VVIGRDGEMPWH-LPEDLRHFKETTMDH-------PVIMGRVTHEGILEAGEPLPGRTTVVLTSRDLETPGN--VVARDLEGALEA
AERA-RHGGTNRLFVAGGATVYEGFLSSLD--RLIVTEIDDDPAGDATFPERDPE-------------TWREVR--GFSFVEYVR--
>tr|M0C2I6|M0C2I6_9EURY Dihydrofolate reductase OS=Haloterrigena salina JCM 13891 GN=C477_15860 PE=3 SV=1
----LVGIVA----VVIGKDGDMPWH-IPADLQHFKETTMDH-------PVIMGRVTYEGILEAGEPLPGRTTVVLTGRNLETPEN--VIAGSLEEALER
AETA-RHDDAERIFVAGGATVYEQYLPTLD--RLIVTEVHEEPDGDTHFPDWDRP-------------SFDEVR--GFAFVEYVR--
>tr|D2RRK6|D2RRK6_HALTV Dihydrofolate reductase OS=Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) GN=Htur_1681 PE=3
----LVGIVA----VVIGKDGDMPWH-IPADLKHFKETTMDH-------PIIMGRVTYEGILEAGEPLPGRTTVVLTSRDLETPEN--VTARSLEEALEA
AETA-RHDAADRIFVAGGATVYEQFLSALD--RLIVTEVHEEPDGDTYFPDWDRA-------------SFDDVR--GFAFVEYVR--
>tr|W0JQX3|W0JQX3_9EURY Dihydrofolate reductase OS=Halostagnicola larsenii XH-48 GN=HALLA_11335 PE=4 SV=1
----LVAIVA----VIIGRDGDMPWH-IPADLEHFKETTIDH-------PVIMGRVTYEGILEAGEPLPGRTTVVLTSQDLETPEN--VTAAGIEGALEA
AETA-RHDDADRIFVAGGATVYEQFLPVVD--RLIVTEVHEEPAGDTSFPAWDRE-------------AWNERR--GFAFVEYGR--
>tr|A0A061LUR5|A0A061LUR5_9MICO Dihydrofolate reductase OS=Leucobacter sp. UCD-THU GN=H490_0115050 PE=3 SV=1
----IGMIWAEARGGAIGRGGTMPWH-LPEDLAHFKTTTWGA-------PVIMGRRTWESLPERFRPLPGRENVVVTRSAGF-APGA-AAVPSIEEALER
TRGSG-AWPPRAAWIMGGGRLYRAAMPFAD--ELVVTRIELDVP-DTFAPQIGPE-WRL-----AEQGGPLVSTGLGYRFERWLR--
>tr|A0A0D7QN70|A0A0D7QN70_9MICO Dihydrofolate reductase OS=Agreia bicolorata GN=TZ00_10750 PE=3 SV=1
----IALIWAEARGGVIGDGGTIPWH-VPEDLAHFKELTLGG-------TVVMGRRTWQSLPERFRPLVGRRNVVVTRDRDF-AAGA-EVGHSLDEVLDA
SVR---DESSAPVWVIGGGDIYAQSLARAS--RLEITEVDLDIA-DTRAPRIDPA-WAV-----AHETDWLESTGIRYRFVSHSR--
>tr|A0A0Q4FIL9|A0A0Q4FIL9_9MICO Dihydrofolate reductase OS=Agreia sp. Leaf210 GN=ASE64_03415 PE=4 SV=1
----VALIWAEARGGVIGDGGTIPWH-LPEDLAHFKEVTLGG-------TVVMGRRTWESLPERFRPLPGRRNVVLTRDRDF-ADGA-DVAHSLDEILDA
GGS---DNTSAPVWVIGGGEIYSQALPRAS--RLEVTEVDLEVA-DTRAPAVDPA-WSP-----AEATDWLESTGIRYRFVSYDR--
>tr|A0A0D0IRT2|A0A0D0IRT2_9MICO Dihydrofolate reductase OS=Leucobacter komagatae GN=SD72_00215 PE=3 SV=1
----LGMIWAEANGGAIGRRGEMPWH-LPEDLAYFKRVTLGD-------PVVMGRRTWESLPERFRPLPGRENIVVSRDAAY-ASGA-VVSSSLEAALDR
LG-------EQRAWIMGGGQLYREAMPKAN--ELLVTRIDIDVP-DTFAPEIGSA-WVL-----VDRGETLTANGTSYRFERYER--
>tr|A0A095Y2V9|A0A095Y2V9_9CORY Dihydrofolate reductase OS=Corynebacterium freneyi DNF00450 GN=HMPREF1650_06645 PE=3 SV=1
----IRMMWAQTSDGVIGDGDSMPWH-IPEDLAHFKATTMGA-------PVIMGRRTWDSLPAKFRPLPGRRNVVLSRSLTPEVPGA-ELAHSLDAALDM
LGD------VPVAWIIGGGRVYRDALHLAD--ECEVTEVDGVFE---ATPVRAPEGWKP-----VRKGEWATSNGPRYRFTTWRP--
>tr|A0A0M2M2K3|A0A0M2M2K3_9MICO Dihydrofolate reductase OS=Leucobacter sp. Ag1 GN=XM48_03430 PE=3 SV=1
------MIWAEARGGAIGRDGDMPWH-LPEDLAHFKRTTLGD-------PVIMGRRTWESLPERFRPLPGRANIVVTRDPGF-AEGA-RVAASVESALDL
AGGAGADGVSSRAWIMGGGQLYRAAMPLAT--ELVVTRIELDVP-DTFAPEIGPE-WRL-----VDPGVPATSTGLGYRFERYLR--
>tr|I0HGA6|I0HGA6_ACTM4 Dihydrofolate reductase OS=Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NB
----VHMIWAQARNGVIGAAGDIPWR-LPGEQRLFKERTMGS-------TVVMGRATWDSLPERVRPLPGRRNVVLTRDPGW-AEGA-VVTHSPEEI--T
---------EDDFWVIGGGGIYAAFLPRAE--HLVRTTIDFDAE-DTFAPDLGPE-WVV-----SSSTGWITATGHRYRIDD-LE--
>tr|G8SFG8|G8SFG8_ACTS5 Dihydrofolate reductase OS=Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) GN=folA PE=3 SV=1
----VHLIWAQAHRRVIGAGGDIPWH-VPGEQAIFKERTAGS-------TVVMGRATWDSLPR--RPLPGRRNVVLTRDPGW-GDGA-HVVHSPDLI--G
---------EVDFWVIGGAAVYQLFLPVAE--HIVRTSIELDVE-DTFAPELGPD-WKV-----TASTGWLTANGIRYVVED-LA--
>tr|A0A0A6X6Y9|A0A0A6X6Y9_ACTUT Dihydrofolate reductase OS=Actinoplanes utahensis GN=MB27_19670 PE=3 SV=1
----IHMIWAEARNRVIGAGNTIPWR-VPGEQRIFKERTMGA-------AVVMGRATWDSLPR--KPLPGRENIVLTRNPAW-AAGA-TVIHSLDDV--K
---------PDDFWVMGGAEVYAEFLPRAG--HIVRTRIDIEVA-DAFAPELGDE-WVV-----TESA-VVEATGVSYVVED-LR--
>tr|U5W8E9|U5W8E9_9ACTN Dihydrofolate reductase OS=Actinoplanes friuliensis DSM 7358 GN=AFR_35130 PE=3 SV=1
----IHLIWAEAAGGVIGAEGGIPWN-VPGEQKIFRERTLGS-------TVVMGRTTWDSLPERFRPLPGRRNVVLTRQSSW-AAGA-EVFGSINDLLKV
---------HDDFWVMGGGAVYTAFLPLAT--HIVRTRIDLAVE-DTFAPRLGPE-WQV-----TAGA-DLTSTGVHYVVED-LT--
>tr|A0A059WQZ5|A0A059WQZ5_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----VHMIWAEARDGVIGAEGGIPWR-IPGEQATFKQRTIGS-------TVVMGRGTWESLPERVRPLPGRRNVVITRAA---LDGV-ETARGVDEVLRK
---------YDDFWVIGGGAVYAAFLPYAT--HLVRTEVDLKIE-DTFAPALND--WPG-----IPGE-WQITTGVRWRVVEHLR--
>tr|E6JAI1|E6JAI1_9ACTN Dihydrofolate reductase OS=Dietzia cinnamea P4 GN=ES5_11181 PE=3 SV=1
----VRMVWAQARGGVIGDGRDMPWH-IPEDLAFFKQATVGR-------PVVMGRATWDSIPERFRPLPGRRNVVCTRDADW-ADGA-ERAGSVERALEL
AGP--------EAAVMGGGQIYAAALSAAD--ECLVTEIDAEAP-VVLAPELDDA-WEL-----VEVGEWITDRSRVEGYDDEVR--
>tr|L1MIZ3|L1MIZ3_9CORY Dihydrofolate reductase OS=Corynebacterium durum F0235 GN=HMPREF9997_00973 PE=3 SV=1
----LRAIWAQTHDRVIGDGYDMPWY-LPEDLAHFKNTTLDH-------PIIMGRATWESLPR--RPLPGRDNIILSTRPPGDSTGA-TVTT--------
-----EPP--QDGWIIGGGQVYASTLPLVD--AITMTLIDAHLARAVFAPDITGE------FTIKSETDWLTSRPLRYKYITYVR--
>tr|A0A0K2GZB1|A0A0K2GZB1_9CORY Dihydrofolate reductase OS=Corynebacterium lactis RW2-5 GN=CLAC_02540 PE=3 SV=1
----VGMIWAQSRDGVLGDGSSMPWH-LPEDLKHFKDTTMGA-------PVIMGRRTWDSLNPKFRPLPGRRNIVLSRTS--TFPGA-EAFASLDQALAA
VAN------EPAVWIMGGGRVYRDGLSLAD--ECVVTQIDIEVS---PVPVIAPDEWEK-----VHESEWLTSTGLRYRLTKWHP--
>tr|A0A0P6SCH1|A0A0P6SCH1_CORUL Diacylglycerol kinase OS=Corynebacterium ulcerans GN=AOT31_03760 PE=4 SV=1
----LRAIWAQSCDGVIGNGVDMPWH-LPEDLAHFKKTTLGC-------PVIMGRKTWESLPPAFRPLPGRNNYVLSRSAAGQSTGA-CVVS--------
-----ELPDVTDAWVMGGGQIYAATLPKVD--EVVRTIVRIELLSAVSAPALGPE------FEIVSETEWMASSSLHYKFQRLRR--
>tr|E2S561|E2S561_9CORY Dihydrofolate reductase OS=Corynebacterium pseudogenitalium ATCC 33035 GN=folA PE=4 SV=1
----LGAIWAQSLDGIIGDGEQMPWH-VPEDLKHFKDVTMGA-------PVIMGRKTWESLNPKFRPLPGRENYVLSSRTPGQSAGA-QVLT--------
-----EMPSLSDAWVIGGGQIYTATLDQVD--RIEVTLMGVNIGKSIYAPEIPEE------FGLAHSTDWLTSKPIKYRFLTYDR--
>tr|E2MUF3|E2MUF3_CORAY Dihydrofolate reductase OS=Corynebacterium amycolatum SK46 GN=folA PE=3 SV=1
----VGMIWAQSRAGIIGDGATMPWH-LPEDLQHFKTTTMGA-------PVIMGRRTWDSLNPKFRPLPGRRNIVLSRSV--SFPGA-ESATSLEAALAA
VAD------EPAAWIIGGGRVYRDALSLAD--ECVVTDIDTDVS---PVPVMAPDDWVR-----VEDGPWQTSTGLRYRFCTWQR--
>tr|A0A0F6QXJ4|A0A0F6QXJ4_9CORY Dihydrofolate reductase OS=Corynebacterium camporealensis GN=folA PE=4 SV=1
----LGAIWAQSLDGIIGDGADMPWH-VPEDLAHFKDVTTGA-------PVIMGRKTWESLNPRFRPLPGRDNIIISRRAPGESAGA-SVSR--------
-----AVPELDEAWIIGGGQLYAATIDQVD--RIEITLMGANIGAAVFAPEVPST------FGLSSSTDWLTSKPIKYRFLTYER--
>tr|E0MWI7|E0MWI7_9CORY Dihydrofolate reductase OS=Corynebacterium accolens ATCC 49726 GN=folA PE=4 SV=1
----LGAIWAQSLDGIIGDGAQMPWH-VPEDLKHFKDVTMGA-------PVIMGRKTWESLNPKFRPLPGRDNYVLSSRAPGTSTGA-TVGK--------
-----TMPALADAWVIGGGQIYTAALDQVD--RIEVTLMGVNIGDAVFAPDIPDT------FGLAYSTDWLTSKPMKYRFLTYDR--
>tr|D7BML3|D7BML3_ARCHD Dihydrofolate reductase OS=Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018) GN=Arch
----LGAIWAQARNGAIGKDGTIPWH-IPEDLALFRKVTWGS-------PVIMGRRTWESLPPRFRPLPGRKNLVVTRDRGF-AEGA-DVVHTVDSAITA
ASE----SGADFSWIIGGAQLYSSTLPLCD--LLVVSHIDIEIA-DALAPLVPDN-WRA-----HPAC-IQTNENLGYHVSVLSN--
>tr|A0A0M4KPV7|A0A0M4KPV7_9ACTO Uncharacterized protein OS=Trueperella pyogenes GN=AN946_00110 PE=3 SV=1
----LGMIWAQGHDRAIGRGGQMPWH-LPEDLAFFRKMTSGH-------PVIMGRKTWQSLPQRYRPLPGRTNVVVTRDPGF-ADGA-LVASSVEEAVRL
AEEAAAEKADPLVWIMGGAQLYAAGMEFAD--GVVVTDVDVDVA-DAFAPEITVD-WE---AGVDPDRGWHVGDGTRYRMSVYRR--
>tr|A0A0M2CRI6|A0A0M2CRI6_9MICC Dihydrofolate reductase OS=Kocuria sp. UCD-OTCP GN=H488_0115870 PE=3 SV=1
----IGAIWAQTADGVIGRAGAMPWS-LPEDMAFFRRTTTGH-------PVIMGRRTWESFPERFRPLPGRTNIVITSSPGR-ARGV-LTAPSYAEAVRL
ART---SPGAERIWVIGGGEVYRQALADAE--HALVTVIDLDAD-DTHAPVLDDG-WAT-----EPVLGPSVSTGLGYRIERRTR--
>tr|A0A0K2JWT0|A0A0K2JWT0_9MICC Dihydrofolate reductase OS=Kocuria palustris GN=KPaMU14_10105 PE=3 SV=1
----LSAIWAQTPDGVMGRDGGMPWH-LPEDLAHFKATTQGH-------PVLMGRRTWESFPERFRPLPGRTNVVVTSRPED-GLQV-IAVSSWREAVRA
GAE---APGGEHLWVIGGARLLEDAMPE-----AVVTVIEIDEP-DTRAPRLETP-WRL-----ERRDEDRLSTGLRWHVEHWRR--
>tr|A0A0J5QP70|A0A0J5QP70_KOCRH Dihydrofolate reductase OS=Kocuria rhizophila GN=ACJ65_03230 PE=3 SV=1
----MGGIWAQSPDGVIGVDGGIPWH-LSEDLKFFARTTIGH-------PVVMGRRTWDSFPETFRPLPGRPNIVITSRPGS-PADV-WAVGSYAEALEL
AVSLEHEEPAREVWVIGGPGVWREAVSHRP--LALVTTVDLDVT-DTHAPALDGS-WSR-----REVADWAESNGTRFRIDEWTH--
>tr|A0A0J1EVM8|A0A0J1EVM8_9MICC Dihydrofolate reductase OS=Kocuria sp. SM24M-10 GN=ABL57_11850 PE=3 SV=1
----VGAIWAQTAEGVIGRGGTMPWS-LREDLAFFRRTTTGH-------PVIMGRRTWESFPERFRPLPGRTNIVITSAPER-VPGV-HTARSYPEAVAL
ARS---SPGAERIWVIGGGEVYRQALADPR--DALVTVIDLAVE-DTHAPVLGDG-WTT-----EPVVGPSVSTGLGYRIDRRTR--
>tr|M7MVH1|M7MVH1_9MICC Dihydrofolate reductase OS=Arthrobacter gangotriensis Lz1y GN=ADIAG_01799 PE=3 SV=1
----IGMIWAEAADGIIGADGAMPWS-LPEDLAHFKATTAGH-------PVIMGRKTWESFPDRFRPLPGRTNIVITRDETRHGAGA-VPVASTEAALKA
ARA---AEGAQEIWVIGGGEIYTAFSPLAH--LAVKTIINVSPQ-DTTAPVLGAS-WSKM--LSEPDSGWLTANGTQYRVEAWEQ--
>tr|A0A0Q2XI82|A0A0Q2XI82_9MICC Uncharacterized protein OS=Kocuria kristinae GN=AN277_02235 PE=4 SV=1
----LAAIWAQAAGEVIGRDGGMPWH-CPADFAFFRERTMGY-------PVIMGRATWQSFPQRFRPLPGRTNIVLSRTVSPGHDGA-RWVRDLPEALRV
AAE--TPSGSERIWLLGGASLYDRALGAED--LVLVTQLDAEVP-DARAPQLGPE-WSVR-----ELGSGVDPAALPYRFLEATR--
>tr|A0A0M0F9B4|A0A0M0F9B4_CELCE Uncharacterized protein OS=Cellulosimicrobium cellulans F16 GN=M768_08755 PE=3 SV=1
----LGLVWAQARDAVIGAGGTMPWH-LPEDLAHFRRVTSGH-------PVVMGRRTWDSLPPRFRPLPGRVNVVVTRQPGW-PGDV-RVAGSVEEALAA
ARE-ARDTGSGEVWVMGGAQLYAATIALAD--RCVVTEIDAVVE-DTYAPAVPAG-W------VAHAGDWATSTGLRYRFLTHDH--
>tr|V8CXM3|V8CXM3_9ACTN Dihydrofolate reductase OS=Williamsia sp. D3 GN=W823_16970 PE=3 SV=1
----IALIWAQAADGAIGRGGDIPWH-LPEDQRYFRKITGGH-------PVVMGRRTWDSLPARFRPLPGRANLVVTRNGQW-ADGA-QTHANVRDALDA
GLH---L--DDTVFVMGGGEIYGAAMESAH--EAYVTEIDLEVS-DTWAPALDPG-WSL-----ESDGGWLESTGVRYRFLRYSA--
>tr|F6FTA4|F6FTA4_ISOV2 Dihydrofolate reductase OS=Isoptericola variabilis (strain 225) GN=Isova_2564 PE=3 SV=1
----IGLIWAQAHDDVIGAGGQIPWR-IPEDFAHFRRTTTGH-------PVVMGRLTWESLPPRFRPLPGRTNVVVTRQADW-AEGA-VVAPSLEEGLAA
AG--YAPGGAQEVWVIGGAQVYAQALPLAD--TCVVTEVDLEVE-DAFAPVLGLD-WT-----PADDGAWATSGALRYRIRTYTR--
>tr|A0A085LEK8|A0A085LEK8_9MICO Dihydrofolate reductase OS=Cellulosimicrobium sp. MM GN=IU11_11870 PE=3 SV=1
----LGLIWAQARDAVIGAGGTMPWH-LPEDLAHFRRVTSGH-------PVVMGRRTWDSLPPRFRPLPGRLNVVVTRQEAW-P--V-RVAGSVDAALAA
ARS-ARTSGSDEVWVMGGAQLYAATVADAD--RCVVTEIDTVVE-DTYAPEIPAG-S------VRDVGEWQVSTGTRYRVVVVSR--
>tr|A0A085LE68|A0A085LE68_9MICO Dihydrofolate reductase OS=Cellulosimicrobium sp. MM GN=IU11_13390 PE=3 SV=1
----LGLVWAQARDGVIGAGGTMPWH-LPEDLAHFRRLTSGH-------PVVMGRRTWDSLPPRFRPLPGRTNLVVTRQEAW-P--V-RVAGTVDAALAV
ARA-ARDAGSDEVWVIGGAQLYAATLAVAD--RCVITEIDAVVE-DTFAPVPGDG-W------VREPGEWRTSTGLRFRVVDVRR--
>tr|D1BYH5|D1BYH5_XYLCX Dihydrofolate reductase OS=Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07) GN=Xcel_2833 PE=3 SV=
----IALIWAQARDTVIGAGGDIPWR-VAEDFTRFRTLTTGH-------PVVMGRRTWDSLPR--RPLPGRTNVVVTRQPDWRPDDV-VVATTLDEALDG
ATQA---PGGDLVWIIGGAEIYGQALAVAD--RLEVTEIDLVVDGDAFAPAIDPV-------------HWHEGH--RYRFRTYVR--
>tr|A0A0Q8UK51|A0A0Q8UK51_9CELL Dihydrofolate reductase OS=Oerskovia sp. Root22 GN=ASE15_00390 PE=4 SV=1
----VGLVWAQARDAVIGARGGMPWH-LPEDLAHFRRVTTGH-------PVLMGRVTWDSLPPRFRPLPGRRNVVVTRQEGW-P--V-VVASSVEEGLAL
ASA-AEESGSGQVWVMGGAQVYAATLPLAD--RCVVTEIDVEVD-DAFAPALAAG-PGGDWAPGAPDGGWQTSAGVRFRMLTYER--
>tr|C4LHD2|C4LHD2_CORK4 Bifunctional dihydrofolate reductase-thymidylate synthase OS=Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717) GN=
----IGVIWASDRDGVIGDGTRMPWH-VPEDMAHFKQLTWGV-------PVIMGSATWSSIPSRFTPLPGRTNIVLSRR--WSPDGV-ILHHSLDAAFKD
IPHPRVAPENVDAWVIGGGEVYREALTRPE--VAVLTEIDAAV--HYFDRPVTAREWVP-----SSRSEWKTSNPLRYRFCYFSK--
>tr|C8RVX9|C8RVX9_CORJE Dihydrofolate reductase OS=Corynebacterium jeikeium ATCC 43734 GN=folA PE=3 SV=1
----IGMIWAQTTAGVIGDGADMPWY-LPEDLKHFKNATTGY-------PVVMGRTSWEALDDGFRPLPGRTNYVITRQDNY-APGG-IIEPSIPSALAN
AAEQTSDERTPTVWVLGGGQVYAQCMPVAD--RIVITEIDMEAPFQVYAPLVP--------FEEHA-EEWQESKPLRYRFCTWTR--
>tr|A0A0A2DQS2|A0A0A2DQS2_9CORY Dihydrofolate reductase OS=Corynebacterium auriscanis GN=MA47_01980 PE=3 SV=1
----IGMIWAQTTAGVIGDGKDMPWY-LPEDLEHFKQATVNY-------PVVMGRTSWEALDDGFRPLPRRENYVVTRNESY-APGG-HVFTSLDHAIAA
AAQFDRP---ALVWILGGGQIYAQCMAVAD--RVVITEIDMSAPFQVHAPAVD--------FTLQSASPWRVSKELKFRICEWTN--
>tr|S4XCA9|S4XCA9_9CORY Dihydrofolate reductase OS=Corynebacterium terpenotabidum Y-11 GN=A606_02890 PE=3 SV=1
----IGMIWAQTTAGVIGDGDDMPWH-LPEDLRHFQATTVGT-------PVVMGRVSWEALHPKFRPLPGRDNHVITRDPGY-APGG-TVHTTLPEAVLA
AGRS---SGAHTVWILGGGHVYRQCVPVAD--RVVVTEIACGSPFRVTAPDMRA-------FTVSD-GPWLTSRPVRYRISEFTR--
>tr|G0HDJ4|G0HDJ4_CORVD Dihydrofolate reductase OS=Corynebacterium variabile (strain DSM 44702 / JCM 12073 / NCIMB 30131) GN=folA PE=3 SV=1
----IGMIWAQTTDGVIGDGADMPWY-LPEDLKHFQQSTLGT-------PVVMGRVSWEALDPRFRPLPGRDNHVITRDATY-APGG-TVHTSLPDAILA
AGRS---TGASTVWILGGGHVYRQCVPVTD--RVVVTEIACGAPFQVYAPDMRA-------FTTHD-GPWLTSRPLRYRICEFTR--
>tr|W5WWS2|W5WWS2_9CORY Dihydrofolate reductase OS=Corynebacterium falsenii DSM 44353 GN=CFAL_02685 PE=4 SV=1
----IAMIWAQTTDGIIGDGKDMPWY-LPEDLQHFKDATVGY-------PVIMGRTSWEALEPAFRPLPGRENFVITRNEDF-APGG-RVVGSIPDAIAE
AAAHMKPELTPTVWVLGGGQIYAQCMDVAD--RVEITEIDMTAPFEVYAPEVD--------FELDA-TEWKTSKDLRFRMCTWRR--
>tr|F8DXH5|F8DXH5_CORRG Dihydrofolate reductase OS=Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026) GN=folA PE=4 SV=1
----IGMIWAQTTDGIIGDGKDMPWY-LPEDLQHFKNSTVGH-------AVVMGRTSWEALGDRYRPLPERENYVVTRNSSY-APGG-HVFTSLSDAIAS
ATAFSRP---ALVWILGGGQVYAQCMPVAD--RIVITEIKMTAPFQVYAPLVE--------FTLNA-SQWKTSKELQYRICEWTR--
>tr|B1VI97|B1VI97_CORU7 Uncharacterized protein OS=Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109) GN=cu1521 PE=4 SV=1
----IAMIWAETTAGIIGDGAEMPWY-LPEDLKHFKNSTMGY-------PVVMGRTSWEALGK-YRPLPGRENFVITRRADY-APGG-HVVASIKDGIAA
AAAFLQDDGRVTVWILGGGQVYAQCMPIAD--RVVITEIDMVAPFQVYAPAMD--------FTVER-SEWFASKGLRYRFETWRR--
>tr|X5EEC8|X5EEC8_9CORY Putative dihydrofolate reductase OS=Corynebacterium glyciniphilum AJ 3170 GN=folA PE=3 SV=1
----IAMIWAQTTDGVIGDGSDMPWY-LPEDLEHFKNSTVGA-------PVVMGRISWEALDPRYRPLPGRDNVVITRNSSY-APGG-TVCASIPEAVVA
AHRI-TDGTVPTVWILGGGEIYRQCLPVAD--RVVVTEIACGAPFSVIAPDMRAT------FTVSD-GPWLDSKPLRYRICEYTA--
>tr|A0A0F9SHU6|A0A0F9SHU6_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_0469690 PE=4 SV=1
----VGMIVA----CLIGYDGLLPWT-NKEDLRRFKELTMGG-------SLIMGRKTYDSLPIGGKKLAGRLKYVLSSQASLKENN--KWFKEWNK----
-----ACPEDKPIWIIGGEEVYKFALDVPD--FIEVTILNQITIKSSRLPHIPYL-------------YMVQSEGFGTSFIEDIR--
>tr|A0A059X8H2|A0A059X8H2_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----LCMITA----TVIGNDLEIPWPKLKADLQNFKNLTIGH-------TVMMGMKTFLSMNS--KPLKDRTNIVVTRNRTWKPEQI-LVAHSLYEALYL
AQDY---GKGEKIWNIGGGMLYSAGLHSFD--EIHVTTIQGHFEGNIKFPGVPKH-------------LYELKNPYKFCYQLYRP--
>tr|H3EN70|H3EN70_PRIPA Uncharacterized protein OS=Pristionchus pacificus GN=WBGene00100766 PE=3 SV=1
----MDLIVAVDAAGGIGKNGIIPWK-LRKDMDHFVKKTSPSQVPPKRNAVIMGRKCWDSIPPNFKPLKGRLNIVLSKTMPEETTPDHWVRNSLDNAMR-
----ELADKIERVWNIGGAEIYKWGLERGIISTIEITKIHQNFDADVMMPDINWENFRKVA-----SSEEQEEKGVKFTFETYHKA-
>tr|A0A0L6U8K9|A0A0L6U8K9_9BASI Dihydrofolate reductase OS=Puccinia sorghi GN=VP01_896g5 PE=3 SV=1
----LNLIVCATKTNGIGQAGKLPWR-LKEDMKFFKHLTTL-APPEQKNVVIMGRKTWQSIPAKFRPLSNRINIVVSRQADPRPQRDSHLVNSLESACEL
IQRSSRRKLVNKVFVIGGAELYKTVLGSKEGNRILMTRILSDHPLDTFFPEFRHNDFLFLSNNPGLLIHPANQKEPMFHF-------
>tr|A0A0L0V8F6|A0A0L0V8F6_9BASI Dihydrofolate reductase OS=Puccinia striiformis f. sp. tritici PST-78 GN=PSTG_11059 PE=3 SV=1
----LNLIVCATKTNGIGTAGKLPWR-LKEDMNFFKYVTSL-SPSKMKNVVIMGRKTWESIPVKFRPLSNRINIIVSRRLDAGEKQDSYLVDSIDSACLL
IRKTGVQNIINKVFVIGGSEIYRSVLDEQ--TSILITRILSDHPIDTFFPEFRSNKFLCLPQH--------GDTGDMFRF-------
>tr|A0A0L0V5L5|A0A0L0V5L5_9BASI Dihydrofolate reductase OS=Puccinia striiformis f. sp. tritici PST-78 GN=PSTG_12334 PE=3 SV=1
----LNLIVCATKTNGIGTGGNLPWR-LKEDMNFFKFVTSL-SPSKMKNVVIMGRKTWESIPVKFRPLCNRINIIVSRRLDAGEKQDSYLVNSIDSACLL
IQTVGVQGIINKVFVIGGSEIYESVLKEQSSSSILITRILSDHPIDTYFPEVRVNKFLCLPPSQG-----EEKTINRFKF-------
>tr|E3KLR5|E3KLR5_PUCGT Dihydrofolate reductase OS=Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) GN=PGTG_11433 PE=3 SV=2
----LNLIVCATKSNGIGQAGRLPWR-LKEDMNFFKSVTTL-APSGCKNVVIMGRKTWLSIPSKFRPLANRINIVVSRQSDPAQQQDSYLVNSIESACHL
IRTTGGEPLVNKVFVIGGSEIYKSVLDSQDNNRILMTRILSEHPLDAFFPEFRANQFLVLPDHGSV---PEPHYQLPFNF-------
>tr|A0A098VNF9|A0A098VNF9_9MICR Dihydrofolate reductase OS=Mitosporidium daphniae GN=DI09_62p160 PE=4 SV=1
----VTIVALCAKTGAIGFQNKLPWRDLNIDMAFFRFVTTVPCPPNPNNAIIMGRKTADSIPVAL-PLPGRVNVVLSKSLENCKHNGILYCKDIQSVCR-
---LSRITALSNILVIGGSEIYSQFLKLG----LLLTFVSLQTPADVFFPSIPANALLEWIGTKRLLRH-QIDTGLILKS-------
>tr|A0A059X7A7|A0A059X7A7_9BACT Dihydrofolate reductase (Fragment) OS=uncultured bacterium PE=3 SV=1
------------RNRGIGKNQTLPWS-LPGDMKYFKRLTCQTSDPQKQNAVIMGRKTWESIPPKFRPLSNRLNVVLTRDAHYQAAADVVIANDLAAALEQ
CDRSDI----EKIFVIGGASIYEQALQGRHVDRIFLTQIDAQYDCDTFFPVFE-DRFGEVGDSTG-----GSDAGVSYRFKEF----
>tr|A0A087CG50|A0A087CG50_9BIFI Dihydrofolate reductase OS=Bifidobacterium psychraerophilum GN=BPSY_1099 PE=3 SV=1
---SVNLIWAQARDMAIGYEGTMPWH-LSEDLRHFKELTISH-------PVIMGRRTWESLEERYRPLTNRDNIVVSRQPHYQAPGAT-VVNDFEAALDI
ARQESIPDDRSEIWVIGGAQLFEAIL--SQADKAFVTFIDAKVDADTFAPDLDDGLWRVSESG-DWQSPQRQSDAVRFRFVNYEKAR
>tr|A0A087VVD2|A0A087VVD2_9BIFI Dihydrofolate reductase OS=Bifidobacterium indicum LMG 11587 = DSM 20214 GN=BINDI_1016 PE=3 SV=1
---SVNLIWAQARSMAIGNQNGMPWH-LSEDMRHFKELTISH-------PVVMGRRTWESMGS--KPLPNRDNIVVTTDPRYRAPGAT-VVSAAEDALDL
ARQETIPADRGEIWIIGGAKLFEHFF--SLADRAFVTDLDLEVPADTFMPDMDDRFWRVAEQG-EWQVPADSESRIRYRFTTYEKVR
>tr|S4HAW8|S4HAW8_GARVA Dihydrofolate reductase OS=Gardnerella vaginalis JCP7276 GN=HMPREF1573_00965 PE=4 SV=1
---PVRLIWGQAYDLAMGVNGGMPWR-LSTDLRYFKAMTISC-------PVIMGRGTWDSMPEKFRPLPGRENIVVSRNPDFNSDGAK-SFTSIEEAICY
AKKWDSSDLGSAVWIIGGGAIFREVIESQIVDAAYVTQIDTRVEADTFAPNIQKGLWKVARDC-DWQESTIKVQFNKYKFMVYEPVK
>tr|A0A087DK86|A0A087DK86_9BIFI Dihydrofolate reductase OS=Bifidobacterium scardovii GN=BSCA_1233 PE=3 SV=1
---SVNLIWAEARDKAIGFEGGMPWH-LAEDMKHFKELTVSH-------PVIMGRKTWESLGAKYRPLPNRDNIVISHDVNYHAPGAT-VVESLDDALDL
ARQEAIPDDRSEIWVIGGAQLFRQAL--PLASKAYVTLLDAVVDADAYAPSLRDGMWHVVGES-PWRKPADLSGNVAYQFVTYQKAR
>tr|A0A0A1GUZ5|A0A0A1GUZ5_BIFLN Dihydrofolate reductase OS=Bifidobacterium longum GN=BL105A_1570 PE=3 SV=1
---SVNLIWAEARDKAIGLNGGMPWH-CAEDMKHFKELTVSH-------PVIMGRKTWESLGGKYRPLPNRDNIVVSHDPMYRAPGAT-VVTSLDDALDM
ARQEAIPDDRSEIWIIGGAQLFAKAL--PFADKAYVTDLAATVDADSYAPDMASGMWREAEVG-EWHTPAKEESGISYRFRILAKTK
>tr|A0A087DE54|A0A087DE54_9BIFI Dihydrofolate reductase OS=Bifidobacterium saguini DSM 23967 GN=BISA_1626 PE=3 SV=1
---SVNLIWAEARDKAIGFNGGMPWH-CAEDMKHFKELTVSH-------PVIMGRKTWESLGLKYRPLPNRDNIVVSRDPLYSAPGAT-VVTSLDDALDL
ARQEAIPDDRSEIWVIGGAQLFAEAL--PFANKAYVTLLDAQVDADSYAPDMKAGLWQEVEVG-ERLKPANPDCGISYQFCILTKTK
>tr|A0A0L0LRM6|A0A0L0LRM6_BIFBR Diacylglycerol kinase OS=Bifidobacterium breve GN=BBRI4_20c226 PE=3 SV=1
---SVNLIWAQARDKAIGLNGGMPWH-CAEDMKHFKELTVSH-------PVIMGRKTWESLGVKYRPLPNRDNIVISHDPMYRAPGAT-VVTGLDDALDL
ARQEAIPDDRSEIWVLGGAQLFSEAL--PFADKAYVTDLDATVDADAYAPDVESGLWHEAEAG-EWLTPAKDEPGIAYRFRILRKTK
>tr|A0A087CTT5|A0A087CTT5_9BIFI Dihydrofolate reductase OS=Bifidobacterium reuteri DSM 23975 GN=BREU_1753 PE=3 SV=1
---SVNLIWAEARDKAIGFQGGMPWH-CAEDMKHFKELTVSH-------PVIMGRKTWESLGLKYRPLPNRDNIVVSRDPLYSAPGAT-VVTSLDDALDL
ARQEAIPDDRSEIWIIGGAQLFAKAL--PFANKAYITTLDAEVDADSYAPDMQAGLWSEAEVG-HWHKPADLDCGIAYRFSVLTKTK
>tr|I4MDL6|I4MDL6_GARVA Dihydrofolate reductase OS=Gardnerella vaginalis 6119V5 GN=CGSMWGv6119V5_04367 PE=4 SV=1
---PVRLIWGEAFGLAMGVNGGMPWR-LSPDLRYFKAMTIGC-------PVIMGRGTWDAMPPKFRPLPGRENIVVTHNPDFVADEAR-TFTSIDAALDY
AREWSPQDLGPAIWVIGGAAILREMLANYHADAAYVTQIEAKVAADTFAPNIHEGKWRVAREG-EFEEAPLKVSNPRYRFMVYAPLQ
>tr|A0A0F4KYY6|A0A0F4KYY6_9BIFI Dihydrofolate reductase OS=Bifidobacterium asteroides GN=JF70_12130 PE=3 SV=1
---SVNMIWAQARATAIGYHNALPWH-LSEDMRHFKELTVSH-------PVIMGRRTWVSMGE--RPLPKRDNIILSSDPGFHAPGAT-VVSAADDALEL
ARQEAIPDDRSEIWVIGGAGVFSTFF--PLADAAYVTDLDLQTPADVFVPDMEERFWHVRDKT-RWMTPAKPDAAIRFRYITYGKVR
>tr|A0A087E3S4|A0A087E3S4_9BIFI Dihydrofolate reductase OS=Bifidobacterium subtile GN=BISU_1624 PE=3 SV=1
---SVNLIWAQASDNAIGFKGTMPWH-LAEDMRRFKELTVSH-------PVIMGRKTWESLDSRFRPLPNRDNFVISGDHTYRAPGAT-VVDDLETALDL
ARQEAIPDDRSEIWVIGGAQIYQATL--PFANKAYITQIDAQVDADAYAPDMNAGLWHVAEQG-EWRTPKKPEGTVRYRFLTLEKGE
>tr|A0A086ZXL4|A0A086ZXL4_9BIFI Dihydrofolate reductase OS=Bifidobacterium biavatii DSM 23969 GN=BBIA_0829 PE=3 SV=1
---SVNLIWAEARDKAIGFNGGMPWH-LSEDLKHFKELTVSH-------PVIMGRRTWESLDPKYRPLPNRDNIVVSHDPQYRALGAT-VAESLDDAMDY
ARQEAIPDDRSEIWVIGGAQLFREAL--PLASKAYVTILDAKVDADVYAPDIRDDLWHIADEG-HWLKPERAESGIKYRFVTFEKTR
>tr|A0A087EC44|A0A087EC44_9BIFI Dihydrofolate reductase OS=Bifidobacterium tsurumiense GN=BITS_0003 PE=3 SV=1
---SVHLIWAQAVGKAIGFNGELPWH-LSEDLKRFKELTVSH-------PVIMGRKTWESLDVKYRPLPNRDNIVVTRSNAYVAPGAT-VANNLEAALDF
ARQEAIPDDRSEIWVIGGAELFQQTL--AMAKKVYVTQIRAQVDADTYAPDMDSGLWRVSEEG-PWLKPADENSRIAYRFVTYERQV
>tr|C4FGJ0|C4FGJ0_9BIFI Dihydrofolate reductase OS=Bifidobacterium angulatum DSM 20098 = JCM 7096 GN=folA PE=3 SV=1
---SVNLIWAQARSKAIGYKGGMPWH-LSEDLKHFQELTVSH-------PVIMGRRTWESLSPKYRPLPNRDNIVITHDTQYRAVGAT-VVGSLEDALDL
ARQEAIPDDRSEIWVIGGAELFREAM--PIANKVYVTDIDAEVDADTYAPDIDAGEWSVTDRS-ARLTPKNADSGIGYRFRTFERVR
>tr|A0A087BMP8|A0A087BMP8_9BIFI Dihydrofolate reductase OS=Bifidobacterium minimum GN=BMIN_0190 PE=3 SV=1
---SVNLIWAQASDLAIGFEGGMPWH-LSEDLKRFKELTVSH-------PVIMGRKTWDSLDPRYRPLRNRDNIIVSHNPHMTAPGAT-VVSDMDAALDL
ARQEAIPDDRSEIWVIGGAAVFRQAL--PFASKAYVTQIRAQVHADTYAPDMDEGSWHVEDDG-EWRSPAADGTMIGYRFVTYARNR
>tr|A0A087ABT8|A0A087ABT8_9BIFI Dihydrofolate reductase OS=Bifidobacterium callitrichos DSM 23973 GN=BCAL_0610 PE=3 SV=1
---SINLIWAEARDKAIGFDGGMPWH-LAEDMKHFKELTVSH-------PVIMGRRTWESLGAKYRPLRNRDNIVVSHDASYRAPGAT-VVDSLEDALDL
ARQEAIPDDRSEIWVIGGAQLFEEAL--PEANKVYVTLLDTKVDADTYAPDIAAGHWDVADRS-PWLKPDKEKKDIRYRFLTYVRAA
>tr|R6HA99|R6HA99_9BIFI Dihydrofolate reductase OS=Bifidobacterium bifidum CAG:234 GN=BN549_00437 PE=3 SV=1
---SVNLIWAEADDKAIGFDGGMPWH-LPEDMKRFKELTVSH-------PVIMGRRTWESLNVKYRPLPNRDNIVVSHNPQYLALGAT-VVTDLDAALDI
ARQEAIPDDRSEIWVIGGAQVFQEAL--PFASKAFVTKIQTSVDADTYAPDMDAGLWEVADPG-HWKRTQKDDSGIRYRFVTYRKIG
>tr|A0A080N3F6|A0A080N3F6_9BIFI Dihydrofolate reductase OS=Bifidobacterium bombi DSM 19703 GN=BBOMB_1080 PE=3 SV=1
---SVNLIWACAQEDALGLDGGIPWH-LGDDMRRFKELTVSH-------PVIMGRRTWDSLDPKFRPLSNRDNIVVSHNCDFKADGAT-VVSSIDEALDF
ARQEAIPDDRSEIWVIGGAQIFKAAM--PYASKAYVTYIQKKVNADTSAPDMESGDWRVESAG-QWTAPSKPEDGIAYRFVEYVRNS
>tr|A0A086ZGP3|A0A086ZGP3_9BIFI Dihydrofolate reductase OS=Bifidobacterium bohemicum DSM 22767 GN=BBOH_0494 PE=3 SV=1
---SVNCIWACASDEAIGFEGGMPWH-LAEDMRRFKELTVSH-------PVIMGRKTWQSLNPEFRPLSNRDNIVVSRDPNFRATGAT-VVDSIEDALGL
ARQEAIPDDRSEIWIIGGAQIFQVAL--PFANRAYVTYLRTRVQTDTYAPDMQSGAWSVEDAG-QWLKPAADQSGIAYRFVTYRKNS
>tr|A0A087E0L7|A0A087E0L7_9BIFI Dihydrofolate reductase OS=Bifidobacterium stellenboschense GN=BSTEL_1447 PE=3 SV=1
---SVNLIWAEARDKAIGLEGGMPWH-LAEDMKHFKELTVSH-------PVIMGRRTWESLDLRYRPLPNRDNIVVSHDHQYRAPGAT-VVDSLEDALDL
ARQEAIPDDRSEIWVIGGAQLFAEAL--PQANKVFVTLLDTAVDADTYAPDIAAAGWQIADRT-PWLKPKKPE-GIRYRFIKYVRSH
>tr|D2Q8R3|D2Q8R3_BIFDB DfrA Dihydrofolate reductase OS=Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1) GN=dfrA PE=3 SV=1
---SVNLIWAQARDKAIGFEGGMPWR-LPEDMKHFTELTVSH-------PVIMGRRTWEALSPKFRPLPNRDNIVISHDPAYSAPGAT-VVDTLDDALDL
ARQEAIPDDRSEIWIIGGAQVFRDAL--PFADKAYVTQISMHVDADTYAPDIASGAWRMAEEG-VWQGTQKGSDDIGFRFVTYEKNR
>tr|A0A087ANH2|A0A087ANH2_9BIFI Dihydrofolate reductase OS=Bifidobacterium gallinarum GN=BIGA_0909 PE=3 SV=1
---SVNLIWAEAHDKAIGVNGGMPWH-LPEDLKHFTELTISH-------PVIMGRRTWESLSAKYRPLPNRDNIVISRNPNYAAPGAT-VVGDLEAALDL
ARQEAIPDDRSEIWILGGAQLFNEAL--PQADKAYVTQIRADVEADTYAPDMDAGLWRVADTS-PWLMPAKSEGGIGFRYVTYRKTR
>tr|A0A072N6Q9|A0A072N6Q9_9BIFI Diacylglycerol kinase OS=Bifidobacterium pseudocatenulatum IPLA36007 GN=AW18_05285 PE=4 SV=1
---SVNLIWAQACDKAIGFEGGMSWH-LPEDMRRFKELTVSH-------PVIMGRKTWESLSPKYRPLPNRDNIVVSRDPAYTAPGAT-VVDSLDDALDL
ARQEAIPDDRSEIWIIGGGQLFREAM--PFADKAYVTQISMHADADTYAPDVKSGAWKVLEEG-VWQNTRKGSGDIGFRFMTYAKNR
>tr|A0A087CWJ4|A0A087CWJ4_9BIFI Dihydrofolate reductase OS=Bifidobacterium ruminantium GN=BRUM_0790 PE=3 SV=1
---SVNLIWAQACDKAIGFEGGMPWH-LPEDMRRFTELTVSH-------PVIMGRRTWESLSPKFRPLPNRDNIVISHDPSYCAPGAT-VVDSLEDALDL
ARQEAIPDDRSEIWIIGGSQIFREAM--PFADKAYVTQISMHVDADTYAPDIHAGAWRVAEEG-MWMKTQKGSDDIGFRFVTYEKNR
>tr|B6XVP3|B6XVP3_9BIFI Dihydrofolate reductase OS=Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 GN=folA PE=3 SV=1
---SVNLIWAQACDKAIGFKGGMPWH-LPEDMKRFKELTVSH-------PVIMGRKTWESLSLKYRPLPNRDNIVVSHDSSYTAPGAT-VVDSLDDALDL
ARQEAIPDDRSEIWIIGGGQLFHEAM--PFADKAYVTQISMHVDTDTYAPDIKGGAWKVAEEG-VWQGTRKGSDDIGFRFITFERNH
>tr|R5H0W5|R5H0W5_9BIFI Dihydrofolate reductase OS=Bifidobacterium adolescentis CAG:119 GN=BN474_01175 PE=3 SV=1
---SVNLIWAQACDKAIGFKGGMPWH-LPEDMRHFTELTVSH-------PVIMGRKTWESLSPKFRPLPNRDNIVISHDPSYFAPGAT-VVDSLDDALDL
ARQEAIPDDRSEIWVIGGAKVFEEAM--PFADKAYVTQISMHVNADTYAPDIHAGAWRVAEEG-TWQKARKGNDQVGFRFVTYERNH
>tr|A0A086Z1Q2|A0A086Z1Q2_9BIFI Diacylglycerol kinase OS=Bifidobacterium actinocoloniiforme DSM 22766 GN=AB656_04390 PE=3 SV=1
---SINLIWAQARANAIGYQGGMPWR-LSEDMKRFKELTISH-------PVLMGRLTWQSMGS--KPLPGRDNVVISGNPDFRAPGAT-VMMSLQDAVEM
ARQEAIPADRSEIWVIGGARIFQEAL--SLADRAYVTELDAQVDADTFAPDMDERFWRVGQRG-SWQQAVDPRRGVRFRYVTYEKVR
>tr|A0A087BWT5|A0A087BWT5_9BIFI Diacylglycerol kinase OS=Bifidobacterium mongoliense DSM 21395 GN=BMON_0908 PE=3 SV=1
---SVNLIWAQARDKAIGFKGGLPWR-LPEDMRRFKELTVSH-------PVIMGRGTWESLSPKYRPLPNRDNFVVSSNAEYVAPGAT-VVPDMDAALDL
ARQEAIPDDRSEIWVIGGAKLFRSAL--PLANRIYLTQIDAKVDADTYMPSLEQRRWRTVEST-DWIKPTSPSTSVGYRFLTLERRR
>tr|A0A087ALJ4|A0A087ALJ4_9BIFI Diacylglycerol kinase OS=Bifidobacterium gallicum DSM 20093 = LMG 11596 GN=BGLCM_0313 PE=3 SV=1
---SLNMIWAEAFDRAIGFNGGMPWH-LPEDLKHFKELTVSH-------PIIMGRRTWEALNPKYRPLPNRDNIVVSRSKDFDATGAV-VVDNIDDALDI
ARQEAIPDDRSEIWVIGGAQLFEQLL--PLASKICITEIDMPVDADTYAPAISPGLWEVAEGS-GWKTPSNPDSPIRFRFVTYQRAD
>tr|M4RDQ3|M4RDQ3_9BIFI Dihydrofolate reductase OS=Bifidobacterium thermophilum RBL67 GN=D805_1353 PE=3 SV=1
---TVNLIWAQARDNAIGFQGGMPWH-LAEDMKRFKELTVSH-------PVIMGRKTWESLDPKFRPLPNRDNIVVSRNSGYQAPGAT-VVENLDDAFDL
ARQEAIPDDRSEIWVIGGAQIFREAL--PFAKQVFVTRIRATVDADTYAPDMEEGLWKLVDVT-PWMLPKHPENGIEYRFETYRKTD
>tr|A0A087BBK3|A0A087BBK3_9BIFI Dihydrofolate reductase OS=Bifidobacterium magnum GN=BMAGN_0364 PE=3 SV=1
---SINLIWAQGVDMAIGFDGGMPWH-LSEDMRRFKELTVSH-------PVIMGRKTWESLPKKSRPLESRDNIVVSRNPEYVAPGAS-VVDSVDDALDL
ARQEAIPDDRSEIWVIGGAQLFEETL--PFATKLYVTQIDTQVEADTYAPDLDRGQWELTERT-GWKTPERTGSSIRYRFLTLERRG
>tr|A0A087B2S8|A0A087B2S8_9BIFI Dihydrofolate reductase OS=Bifidobacterium cuniculi GN=BCUN_1094 PE=3 SV=1
---SINLIWAQANDRAIGFQGGMPWH-LHEDLRRFKELTVSH-------PVIMGRKTWESLG---KPLSNRDNIVISHDRAFRAPGAT-VACDVEEALDL
ARQEAIPDDRSEIWVIGGAQLFEQML--PMASKVYVTQIDANVDADTYAPSLP-ESWQVAGQS-AWMVPERDEG-IRYRYLTLVPRH
>tr|A0A087AIF4|A0A087AIF4_9BIFI Dihydrofolate reductase OS=Bifidobacterium choerinum GN=BCHO_0601 PE=3 SV=1
---SINLIWAQANDKAIGFEGTMPWR-LPEDLRRFKALTVSH-------PVIMGRKTWEALNPKFRPLPNRDNIVLTHDRGFRAPGAT-VVCDVEEALDL
ARQEAIPDDRSEIWVIGGAQLFEQML--PIASKIYLTQIDADVDADTYAPDVDKGDWHVVERT-DWTRPEHADGTIGYRYLTLENRR
>tr|A0A087C7Z4|A0A087C7Z4_9BIFI Dihydrofolate reductase OS=Bifidobacterium pseudolongum subsp. pseudolongum GN=BPSP_0120 PE=3 SV=1
---SINLIWAQANDKAIGFDGGMPWH-LPEDLRRFKELTVSH-------PVIMGRKTWESLNPKFRPLANRDNIVISHDRLFRAPGAT-VACDVEEALDL
ARQEAIPDDRSEIWVIGGAQLFNQML--PLASKVFITQIDANVDADTYAPDLSDGAWKVDERT-DWSVPGKAEG-IRYRYVTLSHQH
>tr|A0A0L7CWN9|A0A0L7CWN9_9BIFI Diacylglycerol kinase OS=Bifidobacterium animalis subsp. animalis MCC 1489 GN=BAAM1489_03265 PE=3 SV=1
---SVNLIWAQANDKAIGYEGEMPWH-LPEDLKRFKELTVSH-------PVIMGRKTWEALNEKFRPLPKRDNIVLSRDRDFRAPGAT-VVDNLEEALDM
ARQEAIPDDRSEIWVIGGSQLFNQML--PMASKIYMTQVDAKVNADAYAPDLTEGSWKLMENS-GWLTPKKPEG-IRYRYLTFERNT
>tr|J0LPA1|J0LPA1_9BIFI Uncharacterized protein OS=Scardovia wiggsiae F0424 GN=HMPREF9156_00421 PE=3 SV=1
---KLNLIWAQAYSQAIGARGAIPWH-LKEDLQHFKELTVLH-------PVIMGRRTWESIDPQYRPLSQRDNIVVSRDMGYKAPGAS-VVDSIDEALHM
ASQPAIPDDRGEIWAIGGAQLYNGLI--YRADNIYITDIDVAVEADAFAPDIDDGVFEVVSDS-GWMVPSGQ-GDIRYRFRTLHRND
>tr|E6K0X9|E6K0X9_PARDN Dihydrofolate reductase OS=Parascardovia denticolens DSM 10105 = JCM 12538 GN=folA PE=4 SV=1
---CINLIWAQAHTPAIGIDGGMPWH-LAEDMKRFRELTISH-------PVIMGRRTWESLNSQRRPLAQRDNIVISSQVDYQAPGAT-VADSVDEALRI
ASQPAIPDDRGEIWVIGGARIYQAML--PYAQNIYLTDVDAIVDADAFAPDVDGGVFECSWDG-GWQKPEKD-QGIRYRFRTLTRID
>tr|U1RBQ5|U1RBQ5_9BIFI Dihydrofolate reductase OS=Alloscardovia omnicolens F0580 GN=HMPREF9244_00496 PE=3 SV=1
---HIKLIWAQAYNLAIGFHGTMPWH-LREDMKYFKERTILH-------PVIMGRKTWESLPENFRPLSNRDNYVVSSNPSFVAPGAT-VVQNLETAIEL
ATQPPIPDDRDEVWIIGGARMYEQSL--NIADEVYITDIDLAVEADAYAPDVETSVWSEEIIQ-DWTAPADS-SAIGYRFRVLKRTQ
>tr|W5IJ34|W5IJ34_SCAIO Uncharacterized protein OS=Scardovia inopinata F0304 GN=HMPREF9020_00501 PE=3 SV=1
---QINLIWAQGYTPAIGFHGSMPWH-LKEDLQHFQELTISH-------PVVMGRKTWESLNPRFRPLSQRDNIVVSHDPAYRAPGAS-VAENLEEALHM
ASQPSIPDDRGEIWIIGGSQLYSQLI--DRADHIYVTDIDLAVEADSFAPNVDDGTFEVSADS-GWLVPAGTVGTVRYRFRTLTRAE
>tr|K7HWT7|K7HWT7_CAEJA Uncharacterized protein OS=Caenorhabditis japonica GN=WBGene00211751 PE=3 SV=1
---KMSLIVAMDADGGIGKNGTLPWS-IKKDMQYFVKTTKKVENPEKRNAVLMGRKCWESIPESRRPLAGRLNIVLSRQLAEQKSNDLIITNSFESALKM
LSEPPFVDSIETIWNIGGAEIYQLAINEKLVDEIHITKIYKSFDADN----------------------------------------
>tr|A0A059X888|A0A059X888_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---IITFVVAMSKNRVIGVKNRLPWV-LPTDLQHFQEKTKGH-------PVIMGSKTYDSIPENRRPLPGRTNIVLTRDRGKTY-PGCLMAHTLGEAITL
AAQQP---GSEEVCIIGGAHVFTEALPL--ANRIYLTEVDAIIDGDAFFPELDPVRWQVKEE-------------------------
>tr|A0A059WN01|A0A059WN01_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---IISFVAAMTKNRVIGVNNALPWNKLKTDMRRFQKITTGH-------PVIYGSSTFLASPQNGRALPNRTNIVLTRDTDKAY-EGCIMAHSLAEAIRT
AEKHE---GNDEIFIIGGSHIFEQALPL--ANRIYLTEVDTELQGDAYFPELDQIRWKAEDE-------------------------
>tr|A0A0G4ASK7|A0A0G4ASK7_9BACT Dihydrofolate reductase, dihydrofolate reductase OS=Parcubacteria (Wolfebacteria) bacterium GW2011_GWB1_47_1 GN=UX70_C0001G0869
---IISVIFAMNGDRIIGNKGGLPWH-LPSDLHRFRALTAGK-------PVIMGRRTFESILRNRKPLPDRCNVVVTRNIAPWF-RNCVFVESLQQGIHL
MN------PSPEVFIIGGSQIYAQALSF--ADRMYFTQVQGKFEGDTTFPQFNPHQWRTVHD-------------------------
>tr|A0A059WJJ4|A0A059WJJ4_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
---TVSIIAAVDRNLLIGSNGEIPWLGVPEDLKRFRELTLGH-------SVIMGRKTYESLPDAVRPLPDRHNIVLTLKLGYSA-SGCTVVNDFGSALD-
AA------ESDEVFVIGGGQVYEQALFL--ANRIYLTEVEGEFRGETFFPNLEWDKWCITAR-------------------------
>tr|A0A059WRQ3|A0A059WRQ3_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=4 SV=1
---KIAVIFAQSLNDVIGQNNELPWAGLKSDMSFFKQATEGG-------AVIAGRKTYESLPELFRPLPSRLNVVLTGDQSFDDPADYLRAPSIPEALQA
---IP---EHRDVYFIGGQRVFEEALMLPELNTIYQTIVEANFEGDTPAPPIDEKNWGVAGV-------------------------
>tr|A0A066XFW3|A0A066XFW3_COLSU Uncharacterized protein OS=Colletotrichum sublineola GN=CSUB01_05733 PE=3 SV=1
MSHELTLIVAATRSMGIGAKGGLPWTGLKKEMAYFARVTKRPSASDARNAVIMGRKTWESIPPRFRPLKGRLNIVISRSHPTDPASAPVKVGSLEQALAY
LRADGVASRLGKVFVIGGAQIYDAALRAPEAKRVLLTKVLAEFECDAFFPLTLSDEWRVLDAWVGVEGGEIEENGTRYEFQMWEK--
>tr|Q5EXQ6|Q5EXQ6_9APIC Dihydrofolate reductase (Fragment) OS=Plasmodium inui GN=DHFR PE=3 SV=1
--------------RGLGNNGTLPWKCNSVDMKYFSSVTTGDDTTKLQNIVVMGRSSWESIPKQYKPLPNRINVVLSKTLTQEVKEKIFLIHNIEDLLLI
LKK----LRYYKCFIIGGAQVYKECLNRNLIKQIYFTRINNAYPCDVLFPEFDESQFRVT---------------------------
>tr|A0A0D9XZ24|A0A0D9XZ24_9ORYZ Bifunctional dihydrofolate reductase-thymidylate synthase OS=Leersia perrieri PE=3 SV=1
--RSYQVVVAATRDMGIGKDGTLPWK-LPGDLKFFKDITMTTSDPSKKNAVVMGRKTWESIPLQFRPLPGRLNIILTRSGSFDFATAEVICASLDSALEL
LATTPYCFTVEKTFLIGGGEVLRQSLNAPYCEAIHLTDIESSIECDTFIPPIDLSVFH--PCYSSF---PVVENGIRHSFT------
>tr|A0A067RN88|A0A067RN88_ZOONE Dihydrofolate reductase OS=Zootermopsis nevadensis GN=L798_04088 PE=3 SV=1
---KLNLISAADQNMGIGWNQKLPWQ-IPSEFHYFLEMTTKPRVTGRQNAVIIGHRTWETMDATSKPHPGALNIVLSRFNPPPLAYNTIVCASLDQVVKM
LTDPEYEGLIDTVWVLGGAEVYQTALKSRFFHRLYLSRIRAVYPCDVFFPEEFDEN--LLVRDSRVLTGVQKDDATGVEFEV-----
>tr|C9DIG7|C9DIG7_TOXGO Dihydrofolate reductase (Fragment) OS=Toxoplasma gondii GN=dhfr PE=3 SV=1
------LVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEPQEGQRVCASLPAALSL
LE-EEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDIVFVPFCPIFISKTFSDNGVPYDFVVLEKR-
>tr|A0A0D2TMX6|A0A0D2TMX6_GOSRA Uncharacterized protein OS=Gossypium raimondii GN=B456_009G199800 PE=3 SV=1
------VVVAATREMGIGKDGKLPWR-LPSDLKFFKELTVTTSDPEKKNAVVMGRKTWESIPLEFRPLPGRLNVVLTRSQSSDITGENVICGSTPSAFEL
LAEDPYCFSIEKVFVIGGGQIFRETLNAPGCEAIHITEIGTSIECDTFIPSIDSSCFQLWY-----SSKPLEENNVRFSFATYV---
>tr|X6MWZ6|X6MWZ6_RETFI Bifunctional dihydrofolate reductase-thymidylate synthase OS=Reticulomyxa filosa GN=RFI_19304 PE=3 SV=1
----FSIIVATFPSWGIGSKGELPWK-IAKELQYFKKTTTTTTNDKKKNAVIMGRKTWESIPPKSRPLKDRLNVVLTKS---DPDSGVLVCGSLDEALEK
LSSPPYNEEIEQVFVIGGGQIYTVSFLHEKLEHIYLTKIFKDIGCDTFLDH------------------------------------
>tr|A0A074YGB0|A0A074YGB0_9PEZI Uncharacterized protein OS=Aureobasidium subglaciale EXF-2481 GN=AUEXF2481DRAFT_27898 PE=3 SV=1
----LTLIVATTAKNGIGKNGTLPWPMLKKEMAYFARVTKTASIQDPQNVVVMGRKTWESIPPKFRPLPQRTNVVISRSENLEGAGEDVIVGSIVSALSS
LKQG-QAAPLGRVFIIGGGAIYKQALDMEEAKSILLTRVEGEWDCDTDFPVVDAEQKTELDEFAG--EDVQQTKGVRYEFRLYEK--
>tr|A0A074Y629|A0A074Y629_AURPU Uncharacterized protein OS=Aureobasidium pullulans EXF-150 GN=M438DRAFT_330605 PE=3 SV=1
----LTLIVATTAKNGIGKNGTLPWPMLKKEMAYFARITKTSSIQKAQNVVVMGRKTWESIPPKFRPLPQRTNVVISRSEKLEGASEDVIVGSISSALSS
LKEG-QAAPLGRVFVIGGAAIYKQALDMEQAKSILLTRVEGEWDCDTDFPVVEADQKSELDGFVG--EDVEEKKGVGYEFRLYER--
>tr|E5A1M1|E5A1M1_LEPMJ Putative uncharacterized protein OS=Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) GN=LEMA_P106160.1 PE=3 SV=1
----LILILAATPSLGIGMNGGLPWPMLRKEMAYFARVTRSSSNAGPINAVIMGRKTWDSIPTTFRPLKDRLNLVVTRDVPASPRGGPISHPSLHSALAH
LYTPSATPLIHKTFLIGGASLYTAALALPCTTHILLTKIHAEFACDTYLSE-DVEKSALWRDFVGEEGEVVEEGGVRFEFCLF----
>tr|R7UK12|R7UK12_CAPTE Uncharacterized protein OS=Capitella teleta GN=CAPTEDRAFT_228287 PE=3 SV=1
-------CAAMLENRGIGFKGKIPWPHIKKDYDHYSQLTQGSIKSGKKVVNIKGRATWQDTGDAEKARPNVITIIISKTLSQLPEGADYLVEDFNEAHCT
ASSLFNAGVVSDVWVMGGQAVYKSAIESPHCSEIHLTEIKCDLEADRFFPEFESL-YSA--QSGNDFYNTVEDGGIQYQFKLYHR--
>tr|T1G9P0|T1G9P0_HELRO Uncharacterized protein OS=Helobdella robusta PE=3 SV=1
-------VVAMDNNRGIGYENHLPWPYIDKDYKHLISLLQGKT------AIIVGRLTWESMKDAERHIEGAVYIVVGKHLLSYPDLICSFVPTLVEAVCL
ACDFYDDKLVTKICFLGGSAIYKEAIESGLCETIYLTRIDASYVCNVFMPDFESE-FILDTDYPDDYYNVYIENGIQMTFQVYKK--
>tr|A8UEB2|A8UEB2_9FLAO Dihydrofolate reductase OS=Flavobacteriales bacterium ALC-1 GN=FBALC1_14652 PE=4 SV=1
--NELTIIVAAGEKNAIGKDNDLIWH-LSDDLKRFKKLTNG-------HHIIMGRKTFESFP---KPLPNRIHIVITRQSDYNVPDGVIVVNSLEDALDA
AR------KDNQPFIIGGGEIYKQSINRVDK--LEITRVHSTFEADTFFPKIDTSIWREVSRTT---HDADEKHAHAFSFITYLK--
>tr|A0A084TM73|A0A084TM73_9FLAO Dihydrofolate reductase OS=Mangrovimonas yunxiaonensis GN=IA57_02735 PE=4 SV=1
--KTLTIIVAAGEDNAIGKDNDLIWH-LSDDLKRFKQLTSG-------HHIIMGRKTFESFP---KPLPNRTHIVVTRQLDYKAPDGVIVVNNMEDALDA
AR------TDLQPFIIGGGEIYKQAMALADK--IELTRVHDTFEADTFFPEIDHTIWKEVNKTS---HPKDEKHAHAFSFITYLK--
>tr|A0A024FE85|A0A024FE85_9FLAO Dihydrofolate reductase OS=Winogradskyella sp. PG-2 GN=WPG_0772 PE=4 SV=1
--NELTIIVAAGEDNAIGKDNDLIWY-LSNDLKRFKKLTSG-------HHIIMGRKTFESFP---KPLPNRTHIVITRQTDYKAPSGVIIVNNLEDAIDA
AK------KDSQPFIIGGGEIYKQSMDLVDK--LEITRVHSTFNADTFFPEIDSTKWKEVSRTS---HDADEKHAHAFSFITYLR--
>tr|A0A090PXU0|A0A090PXU0_9FLAO Dihydrofolate reductase OS=Nonlabens sediminis GN=JCM19294_2451 PE=4 SV=1
--KTLTMIAAAGSNNELGKDGDLVWH-LPDDFKRFKAITTG-------HHIIMGRKTFESFP---KPLPNRTHIVLTRDKNYKT-SQAIVVHDMETALAA
AS------EDEKPFIIGGGEIYQLALPYATH--IELTRVHGSFTADAFFPEIDTNEWNLINKEH---HPKDDKHDYAFDFETWKR--
>tr|W8VWW3|W8VWW3_9FLAO Dihydrofolate reductase OS=Nonlabens marinus S1-08 GN=NMS_1098 PE=4 SV=1
--RKITMIAAAGENNELGKDGDLVWH-LPDDFKRFKALTSG-------HHIIMGRKTFAGFD---KPLPNRTHIVVTRDKSYKS-DNAIVVHDMETALAA
TG------SDQNPFIIGGGEIYSLGMPYANQ--IELTRVHGTFNADTYFPNIDTKHWKLISSEP---HGKDERHDYSFDYETWER--
>tr|L7W5D6|L7W5D6_NONDD Dihydrofolate reductase OS=Nonlabens dokdonensis (strain DSM 17205 / KCTC 12402 / DSW-6) GN=dfrA PE=4 SV=1
--RKITMIAAAGQNNELGKDGDLVWH-LPDDFKRFKALTTG-------HHIIMGRKTFESFP---KPLPNRTHIILTRDKNYKT-EGGIVVHDLETALAT
TS------GDENPFIIGGGEIYKLGMKVADE--IELTRVHGTFDVDTYFPEIDESKWKIKTSLH---HPADDKHKYSFDYETWVR--
>tr|A0A081DCM4|A0A081DCM4_9FLAO Dihydrofolate reductase OS=Nonlabens ulvanivorans GN=JCM19296_2270 PE=4 SV=1
--RVITMIAAAGANNELGKDGDLVWH-LPDDFKRFKSLTTG-------HHIIMGRKTFESFP---KPLPNRTHIILTRDANFKT-DGGIVVHDLSTALAA
AS------SDEEPFIIGGGEIYKLGLEVADR--IELTRVHGSFNVDTYFPEFDEKQWKLIRTEH---HPADDKHEYAFDFETWER--
>tr|A0A098LN48|A0A098LN48_9FLAO Dihydrofolate reductase OS=Jejuia pallidilutea GN=JCM19538_2322 PE=4 SV=1
--SQLTIIVAAAENNAIGKGNQLIWH-LGDDLKRFKALTSG-------HHIIMGRKTFESFP---KPLPNRTHVVITRQTDYKVPLGVIVVNSLEDAIDA
SR------GDKQPFIIGGGEIYKQALPIADK--IELTRVHESFEADAFFPEIDPKVWKETHNTF---HQKDANHDYEFSFITYER--
>tr|A0A0C5WAC9|A0A0C5WAC9_9FLAO Dihydrofolate reductase OS=Siansivirga zeaxanthinifaciens CC-SAMT-1 GN=AW14_05850 PE=4 SV=1
--STLSIIVAAAENNAIGKDNKLIWH-LSDDLKHFKNLTNG-------HHIIMGRKTFESFP---KPLPNRTHIVITRQEDYSVPDGVIVVNNLTDAIDA
AK------KDSNPYIIGGGEIYKQALNIVDK--IEITRVHSTFDADTFFPEIDKSIWKETSKTF---HPKDEKNNFDFSFITYER--
>tr|M7NCZ5|M7NCZ5_9FLAO Dihydrofolate reductase OS=Formosa sp. AK20 GN=D778_02248 PE=4 SV=1
--SEITLIVAAGENDAIGKDNQLIWH-LSDDLKRFKELTNG-------HHIIMGRKTFESFP---KPLPNRTHIVISRQDNYQVPSGVILVNNLEDAFDA
AK------ADKQPFVIGGGEIYKQAMPYADK--IELTRVHEDFEADTFFPKIDTTIWKESQNRY---HAKDEKHQHAFSFITYIR--
>tr|G2EDM6|G2EDM6_9FLAO Dihydrofolate reductase domain protein OS=Bizionia argentinensis JUB59 GN=BZARG_1377 PE=4 SV=1
--SDITIIVAAGENNSIGKDNQLIWH-LSDDLKRFKNLTNG-------HHIIMGRKTFETFK---KPLPNRKHVVITRQDNYQVPEGVIVVNNLADALDA
SR------TDKQPFIIGGGEIYKQAMDFADK--LEITRVHAEFEADTFFPEIDMANWKEVTKTQ---HQKDENHAYDFSFITYIR--
>tr|F6GJI6|F6GJI6_LACS5 Dihydrofolate reductase region OS=Lacinutrix sp. (strain 5H-3-7-4) GN=Lacal_1484 PE=4 SV=1
--KNLTMIVAAGENNEIGKDNDLIWH-LKDDLKRFKSLTSG-------HHIIMGRKTFESFP---KPLPNRTHVVISRQKDYQVPVGVLVVHSLEDAIDA
AK------GDTQPFIIGGGEIYRQAMPLAAK--IEITRVHSTFNADTFFPEIDTTVWKETNSVV---HPQDEDHKYAFSFITYER--
>tr|A0A0D7VYG8|A0A0D7VYG8_9FLAO Dihydrofolate reductase OS=Tamlana nanhaiensis GN=PK35_12310 PE=4 SV=1
--SNLTIIVAAAENNAIGKGNQLIWH-LSDDLKRFKALTSE-------HHIIMGRKTFESFP---KPLPNRTHVVITRQTNYNAPSGVIVVNNLKDAIDA
AK------TDKQPFIIGGGEIYKQALTFASK--IELTRVHHNFEADTFFPEIDETIWKETANIF---HTKDADHDYEFSFITYER--
>tr|A0A0N7HYG9|A0A0N7HYG9_9FLAO Dihydrofolate reductase OS=Algibacter sp. HZ22 GN=APS56_08840 PE=4 SV=1
--SNLTIIVAAAKNDAIGKDNKLIWH-LSDDLKRFKNLTNG-------HHIIMGRKTFESFP---QPLPNRTHVVITRQQNYQVPNGVIVVNNLEDAIDA
SK------NDSQPFIIGGGEIYKQAMTVANK--IELTRVHNDFEADTFFPEIDPSAWEEVSNTY---HEKDENHKYDFSFITYLK--
>tr|T2KHW6|T2KHW6_9FLAO Carbohydrate binding module (CBM48) OS=Formosa agariphila KMM 3901 GN=BN863_2960 PE=4 SV=1
--QNLTLIVAASENNAIGKDNQLIWH-LRDDLQRFKSLTSG-------HCIIMGRKTFESFP---KPLPNRTHIVVTSQQRYKVPHGVIVVHNLDDALDA
AL------EDKHPYVIGGGEIYKQALPFANK--IELTRVHDTFDADTHFPELNLSEWREVQNIY---HAKDEENDHAFSFITYER--
>tr|A0A090W0I0|A0A090W0I0_9FLAO Dihydrofolate reductase OS=Algibacter lectus GN=JCM19300_3970 PE=4 SV=1
--QELTVIVAAAENDAIGKDNKLIWH-LSDDLKRFKSLTNG-------HHIIMGRKTFESFP---KPLPNRTHVVITRQTDYKAPEGVILVNSLEEAIEA
SK------SDVQPYIIGGGEIYKQAMAVADK--IELTRVHESFDADTFFPEVDTSIWKETAHKF---HNKDDKHDYEFTFLTYER--
>tr|A9DJM5|A9DJM5_9FLAO Dihydrofolate reductase type I trimethoprim resistance OS=Kordia algicida OT-1 GN=KAOT1_13007 PE=4 SV=1
--SSLVIIVAAAENNVIGKDNQLIWH-LSDDLKRFKKLTSG-------HHIIMGRKTFESFP---KPLPNRTHIVITRQKDYKAPKGVIVVHTMKEAVSV
TL------SDAEPYVIGGGEIYKQALPFATK--IELTRVHHEFEGDAYFPEIDKKDWKETNNVF---HTKDDKHEYEFSFLTYER--
>tr|A0A023BXX8|A0A023BXX8_9FLAO Dihydrofolate reductase OS=Aquimarina atlantica GN=ATO12_12040 PE=4 SV=1
--SVITMIAAAGENNALGKDNDLVWH-LPDDFKRFKKLTTG-------HHIIMGRKTFETFP---KLLPNRVHIVITRNTNYQA-EGAIVVHNMQDALEI
AK------GDAQPFIIGGGEIYTMGMDHADC--IELTRVHESFEADAFFPEIDTKIWKLEKEEF---HDIDEKHKYPFTYLTYTR--
>tr|A0A0B7BSG5|A0A0B7BSG5_9EUPU Uncharacterized protein OS=Arion vulgaris GN=ORF206478 PE=4 SV=1
------SVAAFCGNRGIGKDGGLPWPHIREDHEFYTGLCKTTKDPNKKNGIIMGRNGWDNMENKNDPKMS--TVVTSTSLSKDEPHCRGVARNFDEAVRM
FYDAPDRHEIETIYILGGRINYEHGVTDPRCTRHIVTRILQNFESDVFFPDFEH-TFRQVPEIDDRIR-QDPTNGIQFRFEVWEKH-
>tr|A0A059X764|A0A059X764_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---IISLIVAVAENNVIGKDNTLPWH-LPADIEYFRNTTM-------GHCVIMGRKNYDSIPPKYRPLRGRTNIVVTRQKDF-KAANCIVVNSVEEALTE
AK----IKEETEVFIIGGADIYKQTMDRA--DKIYYTKIHHAFKGDTFFPSLDANQWALISK-------------------------
>tr|D4GJN7|D4GJN7_PANAM Dihydrofolate reductase OS=Pantoea ananatis (strain LMG 20103) GN=folA PE=3 SV=1
----ISLIAALAADRIIGMENAMPWD-LPADLAWFKRNTLK-------KPVIMGRLTFESI---GRPLPGRLNIVVSSKPG--SAEGVTWVTSLDDAISA
------AGEAEEIMVIGGGRIYEQMLARA--DRLYLTHIDAEVEGDTQFPDYEPDEWHS------TFSDADEQNSHSYCFEILER--
>tr|A0A095U7U3|A0A095U7U3_9ENTR Dihydrofolate reductase OS=Tatumella morbirosei GN=folA PE=3 SV=1
----ISLIAAMAADRIIGMDNAMPWS-LPADLAWFKKHTLN-------KPVIMGRRTFESI---GRPLPGRLNIVISRTPG--ETAGVTRATSLEDALRL
------AGDASEIMVIGGGKIYAQMLEKA--DRLYLTHIDAEVEGDTQFPDYDPDQWHS------VFSDADSNNTHSFCFEILER--
>tr|K8C6V2|K8C6V2_CROSK Dihydrofolate reductase OS=Cronobacter sakazakii 701 GN=BN129_4421 PE=3 SV=1
----ISLIAALAVDRVIGMENAMPWD-LPADLAWFKRNTLN-------KPVIMGRLTWESI---GRPLPGRKNIVLSSRPG--DDDRVVWVRSVEEALQA
------CGDAEEVMVIGGGRVYEQFLPRA--QRLYLTHIDAEVEGDTHFPDYEPDEWQS------VFSDADEKNSHSYCFEILER--
>tr|A0A0A1B6D3|A0A0A1B6D3_9ENTR Dihydrofolate reductase OS=Pantoea sp. PSNIH2 GN=folA PE=3 SV=1
----ISLIAALAADRVIGMENAMPWD-LPADLAWFKRNTLN-------KPVIMGRLTWESI---GRPLPGRQNIVVSSQPA--QAEGVTWVSSLDEALAA
------AGDVEEVMVIGGGRIYEQMLHRA--DRLYLTHIDAEVEGDTHFPDYEPDEWQS------VFSDADEKNSHSYCFEILER--
>tr|A0A071LY38|A0A071LY38_9ENTR Dihydrofolate reductase OS=Mangrovibacter sp. MFB070 GN=folA PE=3 SV=1
----ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTLN-------KPVIMGRLTWESI---GRPLPGRKNIVLSRTPG--NDDRVLWVSSVEEALAL
------CAEDPEVMVIGGGHVYQQFLPMA--HRLYLTHIDAEVEGDTHFPEYETDEWQS------VFSDADDKNSHSYCFEILDR--
>tr|I2BCW2|I2BCW2_SHIBC Dihydrofolate reductase OS=Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74) GN=folA PE=
----ISLIAALAVDRVIGMENAMPWD-LPADLAWFKRNTLN-------KPVVMGRLTWESI---GRPLPGRKNIVISSKPG--DDERVEWVSSVDDAIAA
------CGDAPEIMVIGGGRVYDQFLPKA--QRLYLTHIDAEVEGDTHFPEYEPDEWQS------VFSDADEKNSHSYCFEILDR--
>tr|V8FP57|V8FP57_ECOLX Dihydrofolate reductase OS=Escherichia coli ATCC BAA-2209 GN=folA PE=3 SV=1
----ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTLN-------KPVIMGRHTWESI---GRPLPGRKNIILSSQPG--TDDRVTWVKSVDEAIAA
------CGDVPEIMVIGGGRVYEQFLPKA--QKLYLTHIDAEVEGDTHFPDYEPDDWES------VFSDADAQNSHSYCFEILER--
>tr|U1ZGJ1|U1ZGJ1_9BURK Dihydrofolate reductase OS=Burkholderia cenocepacia BC7 GN=folA PE=3 SV=1
----LTLIVARARNGIIGRDNQLPWK-LPEDLAFFKRTTMG-------APIVMGRKTHESI---GRPLPGRRNIVVTRDATR-RFEGCDTVTSLADALAL
A----ARDGAPEAFLLGGAQLYAEGLTLA--DKLVVTEIDADFDGDASFPAPDAAHWQE------ISRQAAAPNTFGYAFVVYAR--
>tr|Q2SXY8|Q2SXY8_BURTA Dihydrofolate reductase OS=Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) GN=BTH_I1674 PE=3 SV
----LTLIVARARNGVIGRDNRLPWK-LPEDLAFFKRTTMG-------APIVMGRKTHESI---GRPLPGRRNIVVTRDAAR-RFDGCDTATSLGDALAL
A----ERDGAAEAFLIGGAQLYAEGLRHA--DKLIVTEIDQDFEGDASFPAPDPAQWEA------VSRRAAPPNDFAYAFVVYRR--
>tr|K0T9B5|K0T9B5_THAOC Uncharacterized protein OS=Thalassiosira oceanica GN=THAOC_04721 PE=3 SV=1
--------AAASKSRGIGHKGELPWR-LPGDMKHFKKVTTTPPSAGLTNAVIMGRKTWESIPSKFRPLDGRINVILSRSGSAAPPERVIVATSLEQAMAR
IE---ARSDVGSTFVIGGGEIYNQAVESGLVSRVVYTNLPDDAEFDAFFPEMGEGEWECVPYCPGEEEQTDAKSGLRYEFLEYVRR-
>tr|U6LLK1|U6LLK1_9EIME Bifunctional dihydrofolate reductase / thymidylate synthase, putative OS=Eimeria brunetti GN=EBH_0038580 PE=3 SV=1
-----SIVVAMTPQRGIGFKNRLPWPTLPQDFRHFKHLTLYTPGEKRKNAVIMGRKTWESMPPQARPLKGRINVVLSSTAKKPAAAATAVAASIPAALKL
LEE-KFIDKLAQVFVIGGASVFAAALALDIVGCMYITRIGCSFPADVYFPSLNN---------------------------------
>tr|A0A0H5A933|A0A0H5A933_9PSED Dihydrofolate reductase OS=Pseudomonas trivialis GN=AA957_16065 PE=3 SV=1
----LSLIAALGENRVIGVDNSMPWH-LPGDFKYFKATTL-----GK--PIIMGRKTWDSL---GRPLPGRLNLVVSRQTDLALEGAEV-FPSLNAAVER
AEAWALEQGVDELMLIGGAQLYAQGLEQA--DRLYLTRVALSPEGDAWFPEFDQNQWKLVSNLENP---------------------
>tr|S6HNZ2|S6HNZ2_9PSED Dihydrofolate reductase OS=Pseudomonas sp. CF149 GN=CF149_18601 PE=3 SV=1
----LSLIAALAENRVIGVDNSMPWH-LPADFKYFKATTL-----GK--PIIMGRKTWDSL---GRPLPGRLNLVVSRQTDLQLEGAEV-FASLEAAVER
AEQWATEQGVSEVMLIGGAQLYAQGLADA--DRLYLTRVGMSPEGDAWFPEFDQAQWKRVSEELHE---------------------
>tr|A0A0J6L262|A0A0J6L262_9PSED Dihydrofolate reductase OS=Pseudomonas sp. DSM 29165 GN=TU84_17110 PE=3 SV=1
----LCLIAALGENRVIGVDNSMPWH-LPADFKYFKATTL-----GK--PIIMGRKTWDSL---GRPLPGRLNLVVSRQTGLQLEGAEV-FASLEAAVER
AEAWAIEHEVNELMLIGGAQLYTQGLADA--DRLYLTRVDLSPQGDAWFPEFDQAQWTLVSEDKHD---------------------
>tr|A4VRN9|A4VRN9_PSEU5 Dihydrofolate reductase OS=Pseudomonas stutzeri (strain A1501) GN=folA PE=3 SV=1
----LAMIAALAERHVIGRDNIMPWH-LPADLRHFKAMTL-----GK--PIIMGRKTWDSL---GRPLPGRLNLVVSRQADLQLDGAETF-TDLDAALVR
AEQWAREQGVDELMLIGGAQLYAQALGQ--AQRLYLTRIDAQPEGDAFFPVFDEHEWQCIDSQPHP----AEGEAPAYRFETWQR--
>tr|A0A099NV50|A0A099NV50_PICKU Uncharacterized protein OS=Pichia kudriavzevii GN=JL09_g4392 PE=3 SV=1
------LIVALMPELGIGYKGQLPWS-LKQEMKYFRKLTTTTIDPDKRNAVVMGRKTYNSIPPKFRPLKNRLNVVLTRNPKSLNKGHLQISGSLPNTLQE
LKKAEDNGAIEEIFIIGGAEVYNQLMRENYDLCIYLTEVRETLDMDAFF-ELDQSKWS-----------------------------
>tr|A0A0H4JBR6|A0A0H4JBR6_RIEAN Dihydrofolate reductase OS=Riemerella anatipestifer GN=dhfr PE=4 SV=1
-----ALIVAVDQQFGIGKNNDLMWH-LPADMKFFKETTT-------GHIVVTGRKNYDSIPERFRPLPNRENAVLTRNTEYHAPGAVVF-SSLESCLDH
YK-NEV---ERTVFIIGGGQIYREALALDCVQEMFITHVQGEFGADTFFPKFEAVAWN----VETVATQAVDEKN-AYAFEV-----
>tr|U5H3Y3|U5H3Y3_USTV1 Uncharacterized protein OS=Microbotryum violaceum (strain p1A1 Lamole) GN=MVLG_02036 PE=3 SV=1
----LTLIVAATSSHAIGRSSSLPWR-LPKEMAYFARVTKGSTSEKDKNVVIMGRKSWEGIPDRFRPLQGRVNVVVSRQADYNVAADTHLANSLESCITH
L--QSLPTPINRVFLIGGAQLYTLGLTNPSKLRILLTRIKTDFECDAFFPDFVKD--------------------------------
>tr|M5ECP5|M5ECP5_MALS4 Uncharacterized protein OS=Malassezia sympodialis (strain ATCC 42132) GN=MSY001_3122 PE=3 SV=1
----LTAVVAVSLGNGIGANGTLPWR-LPKDMAYFRAATLHARAVPVKNAVIMGRHTWDSIPPRFRPLQGRINVVVSTTMGTPEQADTLLARSLDEAVQL
LQERRYARYLGRAFVIGGAQLYRTALAQRPTAQLLVTRILSPIDMDVFLEEF-----------------------------------
>tr|S4VUT3|S4VUT3_9VIRU Dihydrofolate reductase OS=Pandoravirus salinus GN=ps_768 PE=3 SV=1
-----SIVVAMTASRAIGQRGQLPWGRLPKEMAAFRDLTRTTTDPARTNALIMGRVTFDSLPR-RRPLPGRLHVVLTRR---PP-GTDLTAASLDEALAL
VG------HAEKVFVIGGAQVYADAVAHPACAGVWLTQIASDYDADAFFPSLSDEVYGP----AEALDEFQRECGVTYR--------
>tr|U2UUK9|U2UUK9_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Mitsuokella sp. oral taxon 131 str. W9106 GN=HMPREF1985_01
----LRLIACMDEARGIGRAGGLLVR-LPEDMAHFRHLTMG-------GVVVMGRRTMETLPQG-KPLAGRLNVVLSRTLAKCAGGGFLVCAGLHDLWRR
LGAWHGEEPPRTIWCIGGAAVYAALL--PYAAEAYLTEVPGTHGADVFLPEMA--GFS----------LVSRVMGKRCAFARYVR--
>tr|G5H4K1|G5H4K1_9FIRM Uncharacterized protein OS=Selenomonas noxia F0398 GN=HMPREF9432_01848 PE=4 SV=1
----FELIAACDAENGIGRAGQLLVH-CPEDMAYFRDATMG-------GIVVMGRRTMESLPNG-NPLAGRENIVLSRTLER----GFHVVQEISELWTL
LGRLAF-DEPRPIYAIGGAGCWQLLL--PYVRRARVTRLPGRYGADVFLPPLD--GFI----------CTEKRAGENCIFEIYER--
>tr|D4S4K2|D4S4K2_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Selenomonas noxia ATCC 43541 GN=folK PE=4 SV=1
----LNLIAACDAAGGIGRGGQLLVR-CPEDMAYFRRQTMG-------GIVVMGRRTMESLPEQ-RPLEGRENIVLSRTLER----GFHVVQEISELWTL
LGRLAF-DEPRPIFVIGGEECYRLLL--PYVWRAHVTRLPGRYEADVFFPPLD--GFI----------CTEKRAGENCIFEIYER--
>tr|C9KQJ5|C9KQJ5_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Mitsuokella multacida DSM 20544 GN=folK PE=4 SV=1
----LSMIACIDEGRGIGYRGELLVH-LPEDMKHFRALTEG-------HVVIMGRRTMESLPGK-RPLVNRQNIVLSRQLEG----GFLICHSLPDLWRA
LGRLRAEKPQRKLWCIGGEELYRALL--PYAHEVCLTRLKAVYPADCFFPPLD--DFS----------LVDTDDREGLVFERYEA--
>tr|G5GRX1|G5GRX1_9FIRM Uncharacterized protein OS=Selenomonas infelix ATCC 43532 GN=HMPREF9334_02002 PE=4 SV=1
----LELIAACDEAGGIGRDGCLLTD-CREDMAHFRRTTMG-------GIVVMGRRTMESLPDR-RPLAGRENIVLSRTVEH----GFRVVHDLVELWAL
LGRLVS-EMPRPIFAIGGAACYRLLL--PYVRRAYVTRLTGDYGADVFLPPLD--GLA----------RTELRRGEYCMFELYER--
>tr|J5I982|J5I982_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydrofolate reductase multi-domain protein OS=Selenomonas
----LELIAAVDEDMGIGRAGGLLTS-CAEDMAHFRAETIG-------GIVIMGRRTMKSLPGK-QPLAGRENIVLSRTLDR----GFHIVHDLAALWHL
LGRLDS-DAARRIFAIGGEECYRVLL--PYVHRAHVTRLMGRYGADTFLPPLT--DFA----------RTAACAGKDCIFEIYNR--
>tr|F5RP10|F5RP10_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Centipeda periodontii DSM 2778 GN=folK PE=4 SV=1
----LELIAACDEAGGIGRDGQLLAY-VPEDLAHFRRTTMG-------GIVVMGRRTMESLPAR-RPLAGRENVVLSRTVER----GFHIVHDLAALWAL
LGAMTQ-DAPRPIFTIGGAACYRLLL--PYVRRAHVTRLTGTYGADVFLPPLE--GFA----------LTNSRRGENGMFEIYER--
>tr|U2LIV1|U2LIV1_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Selenomonas sp. oral taxon 892 str. F0426 GN=HMPREF1992_02
----VELIAACDEEGGIGRAGQLLTD-CPEDMAHFRRTTMG-------GILVMGRRTMESLPGR-RPLAGRENVVLSRTMER----GFHIVHDLAELWSL
LGTMTH-SMPRPIFAVGGVECYRTLL--PYTRRAYITRLPGAYGADVFLPPLE--GFA----------LTNSRGGETCMFEIYER--
>tr|E0NYG3|E0NYG3_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Selenomonas sp. oral taxon 149 str. 67H29BP GN=folK PE=4 S
----LELIAAVDDAGGIGRAGHLLTD-CPEDMAHFRSMTMG-------SIVVMGRRTMESLPGR-RPLVGRANIVLSRTMQK----GFYAAADILALWRL
LGRLTA-EEARPIFVIGGAACYRLLL--PYVWRAYVTRLSGSYDADVFFPSLD--GFS----------MTSSSTGQDCIFEVYER--
>tr|J4XIE6|J4XIE6_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydrofolate reductase multi-domain protein OS=Selenomonas
----LMLIAASDAAGGIGRNGQLLTH-CAADMAYFREMTMG-------GIVIMGRRTMESLPAR-RALEGRENIVLSRTMER----GFQIVRDLAELWTL
LGRLVY-DAERPIFAIGGEECYRLLL--PYVHRAYVTCLAGTYEADVFLPPLT--DFV----------RTGCRRREDCIFEIYER--
>tr|L1N844|L1N844_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase OS=Selenomonas sp. oral taxon 138 str. F0429 GN=HMPREF9163_00
----LMLMAACDEAGGIGRNGQLLTH-CAEDMAHFRETTMG-------GIVIMGRRTMESLPGR-QPLTGRENIVLSRTLMR----GFHIVHDLAALWTL
LGRLVY-DAERLIFAIGGEECYRLLL--PYVHRAYVTRLAGTYVADVFLPSLT--DFV----------RTGCRRREDCIFEIYER--
>tr|K9CI18|K9CI18_9FIRM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase OS=Selenomonas sp. F0473 GN=HMPREF9161_00133 PE=4 SV=1
----LELIAAVDAENGIGRAGGLLTD-CPADMAHFRAETMG-------HIVVMGRRTMESLPGE-KPLAGRENVVLSRIREK----GFRLVHDLPALWHL
LGRLAV-DAPRRIFAIGGAACYRLLL--PYAHRAHVTRLPGSYAADRFLPPLE--GFE----------RTGRRPAKDCVFEIYDR--
>tr|I0GUJ6|I0GUJ6_SELRL Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydrofolate reductase OS=Selenomonas ruminantium
----LTMIACVDEKLGIGRAGKLLLY-NKEDMAHFRQQTLG-------QVVIMGRRTLESLPEG-KPLADRINIVLSRTLQR----DVIVCRELSELWTT
LGRIRQDSPAKKFICIGGGEVYSLLL--PYAKELLLTEVAGEFAADTFFPAVD--DFF----------EASRETRHELSFVRLVR--
>tr|C0EGY7|C0EGY7_9FIRM Dihydrofolate reductase OS=[Clostridium] methylpentosum DSM 5476 GN=folA PE=4 SV=1
----MKCIVAVDQAWGIGCNGLLYS--IPEDMAFFRKTTLN-------KAVVMGRHTLESLP-KSRPLKNRLNIVMSRDRSLQIGGAITSLQDLGVALSI
CD-------SDDVYVMGGYAVYSLLLDFCGQ--ALITKIQGQREADRFFPNIDRDNNWTLSE----QSDVRSHNGLCYSFCVYAN--
>tr|F2QLF4|F2QLF4_PICP7 WD repeat-containing protein YCR072C OS=Komagataella pastoris (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1) GN=RSA4 PE=3 SV=1
----VNIIVALIPGHGIGLKGKLPWS-LKNEMKYFRLLTTNTISPTSKNVVIMGRNTWESIPSRFRPLQNRLNIVLTRNANISVEGAAVLADSLKNGLDI
IEKTG---NIEEVFLIGGADLYNQCLASGLVDRIFLTEVNGQIETDVSI-KIDPSQWQVLEKVNGFQLDGNKEGELVYDFTLLER--
>tr|W8ZI85|W8ZI85_9BACL Uncharacterized protein OS=Paenibacillus sp. P22 GN=BN871_CL_00100 PE=3 SV=1
-------IACMDRDRLIGRGNDLPWK-LPEDMSYFKERTM-----GK--TVLMGRKTFESFG--SRPLKNRRNVILTRDAGFTPEGAET-VHSLDEALQL
EPA------GEELMVIGGEQIYELLLPHADC--LLLTEIDASFGGDAFFPSFREEEWRLADSYPGKG---DEKLGVAYRFNRYER--
>tr|W6K9D2|W6K9D2_9PROT Uncharacterized protein OS=Magnetospira sp. QH-2 GN=MGMAQ_1565 PE=4 SV=1
--MRISLIVAMAENRIIGRANGLPWR-ISADLKHFKAITTG-------KAVIMGRKTYESIG---RPLPDRHNIVVSRDLDFEP-DCVEVARSLKAALHA
AEG----WGDDEAMVIGGAAIYEQALAQ--ADRLYLTEVHAEVQGDVSFPEFDPCQWRELSRERHS---AGQGADHDYSFVVLER--
>tr|Q6LV44|Q6LV44_PHOPR Putative Dihydrofolate reductase OS=Photobacterium profundum GN=STM0087 PE=3 SV=1
--VKISMIAAMAKDRVIGKDNAMPWH-LPADFAWFKKSTLG-------KPIVMGRKTFESIG---RPLPGRLNIVISRNPEFSVEG-VTVVADIEAAKHA
A------GDIGELMVIGGGSIYEACLPS--ADRLYLTFIDLDVDGDTCFPDWGE-GWIKSYTE-HY--SADEKNAHDMQFVILERN-
>tr|A0A059WY43|A0A059WY43_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
----VSFVLARAGNGVIGANNAIPWR-IPEDMKRFKAITMG-------KPIIMGRKTWDSFPK--KPLPGRTNIVITRDANWRADGA-VAVHSLDEALKR
AES----EKPDEIAVIGGAEIYKLAFPYP--RRIHLTEVHADVAGDATMPAFDPALWRETAREDH-----VTADGLRYSYVTLDRR-
>tr|A0A059X7I3|A0A059X7I3_9BACT Thymidylate kinase OS=uncultured bacterium GN=tmk PE=3 SV=1
---TIVLIAGVAQNNVIGQQGALPWY-ISEDLKRFKELTTG-------HPVVMGRKTYESIVQRGKPLPHRKNIVVTSNTSYQAHPEVLLCSSVQEALMK
AQQ-----SSEKVFVIGGQQIYEQTLPL--AHELEITHVHKAFEGDAYFPEIKKEEWKEVKREE-------RTGDMHYSFVSYQRS-
>tr|C7NFY1|C7NFY1_KYTSD Dihydrofolate reductase OS=Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) GN=Ksed_09350 PE=3 SV=1
--QSLTLVVAVARNGAIGRDGDLPWH-LPGDLKHFKDTTMG-------GTMVMGRRTFESFP---RPLPGRRHVVMTSDPTWLPGDEVLVARSWAEALLM
A-------GDGEVFVVGGAGVFADALPV--ADRLVLTEVDQSPQADTFFPPVDPTVWHESSRT----------PGEGYAIVEYRR--
>tr|K1DZA4|K1DZA4_9MICO Dihydrofolate reductase OS=Janibacter hoylei PVAS-1 GN=B277_05963 PE=3 SV=1
--QRLVLVAALGANRAIGVDGGMPWH-LPEDLAHFKALTMG-------GTMIMGRRTWDSIG---RALPGRTTIVVTSDHAWSAP---IVVHSLAEALVA
A-------GPGEVHVLGGGEIYRQTIDL--ASRLELTEIDRSPE-EVFFPEVDARVWREVRRD----------PREGFDFVTYER--
>tr|C8X9J8|C8X9J8_NAKMY Dihydrofolate reductase OS=Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) GN=Namu_2811 PE=3 SV=1
--PTVVLVAAVARNGVIGAAGTMPWH-IPADLKRFKRLTMG-------HPMVMGRKTFESMG----LLPGRRSIVITRDPHWRAPGA-EVADSLDRAIAL
GAQ-----TDPVVMVVGGGEIYAQALPR--ADRLEITHLDLSAPGDTVFPAIDPALWAVTDRE----------EADGYAFVTYRRRR
>tr|R5KGS8|R5KGS8_9CLOT Dihydrofolate reductase OS=Clostridium sp. CAG:264 GN=BN572_01365 PE=3 SV=1
-RTMIGLIVARSKNNVIGKNGQIPWR-IKGEQKQFKELTTG-------NTVVMGRKSYEEIG---HPLPNRMNIVVSNTANYSG-ENLLTVHSLQEALDS
VK-------EGNVYISGGYGLFKEALPL--VDTMYITEVDTVVEGDVFFPEFNADEFDITTGE-------SGGDDITFTRMTYTRKK
>tr|E0QM59|E0QM59_9FIRM Dihydrofolate reductase OS=[Eubacterium] yurii subsp. margaretiae ATCC 43715 GN=folA PE=3 SV=1
--DMISIVVAYSNNRVIGKDNKMPWD-IKGDLEFFKNLTMG-------NIIVMGRRTYESIG---RTLPGRINIVISRRDEKSREENLYLAKSLEEAIFI
AKSSMTKIQPKEIFIIGGESIYEQSIDI--ADRIYVTKINYDYDGDKYFPYFDEDKYRTKILK-------SEDLPVRHSFILYEK--
>tr|R6CA06|R6CA06_9CLOT N-acetyl-gamma-glutamyl-phosphate reductase OS=Clostridium sp. CAG:510 GN=argC PE=3 SV=1
---MIGLIVAYTKNRVIGSEGRIPWR-IKGEQRRFKELTTG-------NVVIMGRKSYEEIG---HPLPNRYTVVVSSTADYEAE-NCITVNSLPAAIKK
AEE--L-CPGKNIYISGGAGIYKEGIAL--AEKLFVTEIDAEIEGDTYFPEFDVSAYERTIEE-------IVDGEIPYSYVTYSKK-
>tr|W0BBF6|W0BBF6_9GAMM 4-hydroxythreonine-4-phosphate dehydrogenase OS=Legionella oakridgensis ATCC 33761 = DSM 21215 GN=pdxA PE=3 SV=1
--TIISLIAAVDEHGALGKDNQLLCH-LPADLRHFKELTLG-------KPILMGRKTYESIG---SPLPGRLNIILSRQLTQI-SGA-VVVDTLHHAFEL
TC------HEPEIMVIGGAHVYEQAILV--AQRIYLTKIHHQFEADVFFPTVDESIWQVQEAVF---RPHDEKSKYDMTFYRYEKV-
>tr|E0QSC4|E0QSC4_9ACTO Dihydrofolate reductase OS=Mobiluncus mulieris ATCC 35239 GN=folA PE=4 SV=1
----LGMIWAQDHKRILGANGGMLWR-IPADFQFFKRTTLG-------WPVIMGRTSFEALG---RPLPGRRNIILTRRPDALKTGGIEIAASVSAALEL
CA------GTEQVWITGGGRVYQEVMDARIADLLVVSQLDLIAPKVTVAPVIDPQRWQLDESRSD--ATWRPSGDGAWRVQYYVP--
>tr|E0N4Y4|E0N4Y4_9ACTO Dihydrofolate reductase OS=Mobiluncus curtisii subsp. curtisii ATCC 35241 GN=folA PE=4 SV=1
----LGMIWAEDKAQVLGAGGKMLWH-VPADFKHFKDTTMG-------SPIIMGRASFLSLG---QALPGRRNIVLTGSREFTA-PDVEIAHSLEEALEL
CA------RTPQVWITGGAKVYREVMELGLADLLVVTQLDMTAPTVAYAPVIDPVRWQLDLTRSD--ENWRPSGDAAWRVRYYIP--
>tr|D0YR49|D0YR49_9ACTO Dihydrofolate reductase OS=Mobiluncus mulieris 28-1 GN=folA PE=4 SV=1
----LGVIWAEDCHHVIGAGGGMVWR-VPDDLRFFKETTMG-------CPVIMGTGSFKALG---EPLKGRRNIILTRHPSALAEGLIETASNLDDAIKL
CA------GTKEVWITGGGVVYQEVMDAGIADLLVVSQLDLIAPKVTVAPVIDPQRWQLDESRSD--ATWRPSGDGAWRVQYYVP--
>tr|G9PHK8|G9PHK8_9ACTO Uncharacterized protein OS=Actinomyces graevenitzii C83 GN=HMPREF0045_01736 PE=4 SV=1
----VGLIWAQSDDGVLGVDGDMAWR-VPADFKHFRAATMG-------CGVVMGSRTWHSLG---GALPGRNCVVLTRRGVAGP----TCASTLDEALQI
YR------TFPRVWVVGGAQVYQLALDSDLADVLVISELELDAKQLTLAPQVDYSRFRLEASASD--SHWRPSGDARWRVKTWVR--
>tr|L8GV53|L8GV53_ACACA Dihydrofolate reductase OS=Acanthamoeba castellanii str. Neff GN=ACA1_057010 PE=3 SV=1
--TKFSIVVAVTENNAIGVENRLPWH-IPKELAAFRTLTRAE---GATNAIIMGRRTYELFPN--GPLPGRTNIVLSRNPAFEALPGVIVSCDLGSALKK
LG-----VVTEKVFVIGGAQLYREALLHPQCEAIYLTSVSGAPKVDVFFPDIPGDAYKIDVGYA-KSGVVHTVSPITYEYKRYRK--
>tr|A0A010Q5K9|A0A010Q5K9_9MICC Dihydrofolate reductase OS=Nesterenkonia sp. AN1 GN=BG28_00825 PE=3 SV=1
--TEIGMIWAQTHTGVIGDAGAMPWH-LPEDLAHFKTTTRG-------APVVMGRRTWESFPEKYRPLPGRQNIVITTDAHAAERGG-HPVASLDEGLEL
ASG----FATERIWVIGGGQVYSETVTRGIADLAVITVIQSPASGDTSAPALTA-DWELTRRDPAV--GTHGANGLQYHIETHRRK-
>tr|F4QC73|F4QC73_DICFS Dihydrofolate reductase OS=Dictyostelium fasciculatum (strain SH3) GN=DFA_12124 PE=3 SV=1
--RIISMIFAVSENHVIGKGNDLPWH-LPKDLKFFRDTTNG-------HPVIMGRRTFESIGC--KPMPNRYNIVVTSRSAESDSGKLAFVSSIENGLQL
T------KDIQKVFIIGGTKIYEDGLQF--SNELLITHVHSDVQGDIFLKIFNNSHWNVLTEEFHS-KEHDQLQQFDFTIKTYNRR-
>tr|D7GU12|D7GU12_9FIRM Dihydrofolate reductase OS=butyrate-producing bacterium SS3/4 GN=CK3_16340 PE=4 SV=1
---AMNIIAAVDKHWAIGNRGKLLVT-IPDDQKLFREETKG-------KVIVMGRKTLESLPAG-QPLAGRKNVVLTRDEAYKVKGC-EIFHNLKDAMEF
LKQ----FKSEDIYIIGGAEIYEAFLPY--CDTAHITWIDYEYMADTWLPNLDKDDWEVTADSD-----EQTYFDLCYEFRRYERT-
>tr|A5P9U6|A5P9U6_9SPHN N5-carboxyaminoimidazole ribonucleotide synthase OS=Erythrobacter sp. SD-21 GN=purK PE=3 SV=1
--MSLFLIYARAANGAIGKQGRLPWH-LPADLKRFKALTMG-------KPMIMGRKTFESLP---GLLPGRRHIVLTRKERWDSTGA-EVVRSVGEAVAK
A-------GEGDIAVIGGAAIFDVFMPL--AKKVELTEIHRDFDGDVFMPPLGP-EWDLAGTEDFE----ADGDTPAYSFHTYRRV-
>tr|W6ARN2|W6ARN2_9CAUD Dihydrofolate reductase OS=Erwinia phage Ea35-70 GN=Ea357_121 PE=4 SV=1
----IAMIAAIDRGQGLGKDNELLYR-IKEDMKYFKEMTLH-------SPVIMGRKTYESLP---NPLVDRLNIVITTAPTNTTRSGVVFVNSKEEALLH
AKGYLAEHGGDKIWIIGGASIYAAFLPD--AKEIHLTTIGTEEDADTFFPEVDLRQFNAA---------------------------
>tr|A0A0K3CDE0|A0A0K3CDE0_RHOTO BY PROTMAP: gi|342319919|gb|EGU11864.1| Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Rhodotorula glutinis ATCC 204091] 
--LSLTLIVAATPSHGIGRNSTLPWR-LSKEMAYFARMTKGEGQ-ELANAVIMGRKSWEGIPSKFRPLPGRVNVVVSRQQGFDLGPHTHLASSLPSAVDI
LRSA--NSSLNRAFLIGGAQLYNATLEEYTVDRVLLTRLFTEYDCDTFLRDFEA---------------------------------
>tr|E3CIH7|E3CIH7_STRDO Dihydrofolate reductase OS=Streptococcus downei F0415 GN=folA PE=3 SV=1
-AKKILAIWAQDQAGLIGANQTMPWH-LPAELAHFKQTTMG-------QAILMGRKTFDGMGR--RILLGRQILILTRDKSYQVE-GVKTVSSRQEVLDW
FEQ-----QDKDLYIAGGAGVYRTFLDD--YTGLVKTTIQTRFEGDTYFPEMDMAPYQLVSQENH---GKDEKNPYDFTIATYQKI-
>tr|A0A0F9I9V6|A0A0F9I9V6_9ZZZZ Uncharacterized protein OS=marine sediment metagenome GN=LCGC14_1903140 PE=4 SV=1
------MIVAVDHTGGYANGVTIPWS-FEADLKHFKKVTAG-------NACIMGRKTYDDIAN--KRREQKPNFRVLRTSYVTEAQGAEVFPNVSAVLET
LP-----NNNQEIYLLGGSRMWIQYLNR--AKQIWMTIVPGKYKTNKKFPIEFMKDYEIVE---GHK---EETDQGELMFVRYVRK-
>tr|A0A0M3GIR4|A0A0M3GIR4_9RHIZ Dihydrofolate reductase OS=Rhizobium phaseoli Ch24-10 GN=RPHASCH2410_CH18915 PE=3 SV=1
------SIVASYPDNVIGIENRLPWH-LRTDLQIFKKRTSG-------HAIIMGRKTFESLGN--RPLPNRTNIILSR-SEIRDVETALLFAD----ISS
IT-----AGKLEFFVIGGEQIYKIFERY--INQVFLTEVCGHINGDAKFETNFEKDTVGKR---GAK---SEHDQFPFRITRYERR-
>tr|A0A0E9ET64|A0A0E9ET64_CHLTH Dihydrofolate reductase OS=Chlamydia trachomatis GN=folA_4 PE=4 SV=1
----LILLIACDNRFAIGNKGDMLFH-IPDDLHHFKNTTMG-------HIVVMGRKTLESLPG-GKPLPGRLNVVMTRQEREES-ENLRVVHDR-EALEA
LLAEENPHGTRKVFHVGGGGLVKSLWDL--IDEAILTRVDATFEADTWIPDFDASEFQLVDKGE-----SGEYKGLHWQIYHYKR--
>tr|A0A059X751|A0A059X751_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---DLSLMVAMTPYQVIGRGNTIPWR-IPSDMKRFQDVTLGI------GTMLMGRLTWESLPR--RPLRDRHHIVLTRTGGIEATEQVTPVDSFEAACEV
VRR-----LGGKACVIGGTQVYELFFPI--VSRLYVTCVHGKIEGDKLFPIADENGWNWVS--------------------------
>tr|G9I9H4|G9I9H4_9CAUD Putative dihydrofolate reductase OS=Pseudomonas phage OBP GN=OBP_241 PE=4 SV=1
--LSYSLILAADERGGIGLDNDLPWKLNKSDMQWFRDKTKG-------KIIIMGYNTWVSIGR--KPLPGRYNVIITEKHYDETEGHSAVCKSPSLAVAY
LENLGYATRGGEVMVIGGARIYEAFMEY--ASRIYLTTFEGEFKADTFVK-LDLTDFEL----------------------------
>tr|B8X162|B8X162_ECOLX Dihydrofolate reductase-like protein OS=Escherichia coli GN=dfrA17 PE=3 SV=1
---KISLISATSENGVIGNGPDIPWS-AKGEQLLFKALTYN-------QWLLVGRKTFDSMG----VLPNRKYAVVSRKGISSSNENVLVFPSIEIALQE
LSK-----ITDHLYVSGGGQIYNSLIEK--ADIIHLSTVHVEVEGDINFPKIPE-NFNLVFEQF------F-LSNINYTYHLEKR--
>tr|R4V9G3|R4V9G3_SALET Dihydrofolate reductase type A7 OS=Salmonella enterica subsp. enterica serovar Indiana GN=dfrA7 PE=3 SV=1
---KISLISAVSENGVIGSGPDIPWS-VKGEQLLFKALTYN-------QWLLVGRKTFDSMG----VLPNRKYAVVSKNGISSSNENVLVFPSIENALKE
LSK-----VTDHVYVSGGGQIYNSLIEK--ADIIHLSTVHVEVEGDIKFPIMPE-NFNLVFEQF------F-MSNINYTYQIWKK--
>tr|U6N4U2|U6N4U2_9EIME Bifunctional dihydrofolate reductase / thymidylate synthase, putative OS=Eimeria necatrix GN=ENH_00073120 PE=4 SV=1
--YPISIVAAMTPKRAIGISNKLPWPPLPPDFKHFSHLTQFTRPPYLLNCVIMGRKTWESLPANSRPLKGRVNVVVTSFKTAEPEPLLLVAPSLPAALLL
LEQQF-LDVLNEVFIIGGANLYASGLALGIVSTLYITRVAVEFAADVFFPQFGP---------------------------------
>tr|R7AZP2|R7AZP2_9CLOT Uncharacterized protein OS=Clostridium sp. CAG:43 GN=BN653_01284 PE=4 SV=1
-PRHFQLIAAVDRNWGIGNKGQMLTV-IPADQKLFRQETMG-------KIIVMGYKTFLTFPAQ-RPLDGRINLILTKKKALSVKGA-EICHSVEEALVR
LKQE-KHLTDVDVVIIGGESVYRQFLPF--CDTAQITWIDFSYVADTHMVDLEKEGWELVRRSG-E----QTFFNLCYEFREYRK--
>tr|U1MVL9|U1MVL9_9EURY Dihydrofolate reductase OS=halophilic archaeon J07HX5 GN=J07HX5_00303 PE=3 SV=1
----LIAVAAVAENGVIGSEGALPWPSLPADRHQYRARVAD-------DPVALGRRTFEAMQ---ANLPGTTQIVLSRSERHYAAESVFLVQTVVEALDQ
TR----ALGADRLYVLGGAAIYALFQPH--IDRMVLSRVPGEYEGDAFYPEWDADAWTLVDR-------------------------
>tr|A0A095X9M1|A0A095X9M1_9FIRM Uncharacterized protein OS=Tissierellia bacterium S7-1-4 GN=HMPREF1634_08720 PE=4 SV=1
----VSIILACDLNYGIGIDGDMLFW-IDDDLKRFKEITMG-------KNLYMGRTTFESTG----PLEGRKMIVLSSKDPE---GADEVIHDFDEFRER
LK------NDKNGMLIGGANTVNSMIED--IDYMYLTIVLKKYKADSTINPI-KNGFALENESEII---IDEKTGLNYKYVVFKRK-
>tr|A0A059WZT1|A0A059WZT1_9BACT Dihydrofolate reductase OS=uncultured bacterium PE=3 SV=1
---NYAAIYAVSENDVIGHENSLPWDLQKADLSNFMTLTKSPDRNGNPPVLICGGRTLESLG--YKPLKNRLNIVMTTNPDKDEAGG-LAFTNKQDLLAY
LDT----IPNEEIFIIGGRDMWVMFWKE--IGIVYKTEIRARVKGAILFPPTSLESFTEILSKKNW--PVDEKNQFPSTFRVYKRP-
>tr|A0A0B5ATM5|A0A0B5ATM5_9BACL Uncharacterized protein OS=Jeotgalibacillus sp. D5 GN=JMA_42480 PE=4 SV=1
-----------------------LYR-ITHDFEWFKTLTKG-------HIVVMGYKTFLEIG---KPLPERINLVYVDAMRPKLPEGIIPVSSLDEIFLI
AGF----NSHLEIFILGGEKLFKEAFEY-GVDTIYRTFVHEEKDGDVHFIPFEKASYRLKNVLPDTFENHIDKKHVKYQFEIWEKR-
>tr|K4EJH1|K4EJH1_PROVU DHFR superfamily protein OS=Proteus vulgaris GN=dhfr PE=4 SV=1
--KRLSMILARDLNGAIGYEGSLAIK-SDNDFAWYKKITKPF------KHAVCGRVTYEDLPD---IVKKRRFIIITRNPDKYAPEAQ--YMTLSDALKE
LQVW--DVPGHDIICLGGAEIYKALLPY--VSTVYLTTFFSVDEADTYFNDFT-DKWESV---------------------------