>seq_1
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQE
EAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRT
DNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPT
KQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST
IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF
>tr|M7BDS5|M7BDS5_CHEMY Smoothened like protein OS=Chelonia mydas GN=UY3_16573 PE=4 SV=1
----------------------------------------------------------------------------------------------NSDLKI
QKSHSHYYRKCLRNAPRCWDAIQPLLCAVYMPKCEDGQVELPSQTLCQATRGPCTIVERERGWPDFLKCTTDRFPEGCPNEVQNLKFNSSGHCEAPLVQT
DNPKSWYEDVEGCGIQCQNPLFTEHEHRDMHVYIAAFSSVTIFCTFFTLATFVADWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARGEIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLVTWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRFR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFACPFYDFFNQAEWERSFREYVL-----------
---------------------------------------------------LTGQSDDEPKRIKKSKMIAKAFSKRKELLHNPEQELSFSMHTVSHDGPV
AGLAFDINEPSADMSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPDERANLWVVDAEISPELEKRASRKKKTRRKKKEVCPLGP--AICDTPQARSA
VPRLPKLPRQKCLVSNPRLGLAHSRKHDAFHLISNPFCPETGPQESSFRPPAAGSGPRTHGRRAGFAPLHSQTNLMDAELLDADSDF
>tr|W5P289|W5P289_SHEEP Uncharacterized protein OS=Ovis aries GN=SMO PE=4 SV=1
-------------------------------------------------------------------MAC-----SVAKRDALGPGAAGSVGQGEEGSSL
QCIHTVATPPGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPT
KKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEKANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLVPPPELHLPSLSRSA
W----------WLQAPGDLGNPADLEPGPWSPTPSAQSPAPPPPPPP-----APHWPGGRAAGRDWGPFTPAPT-------------
>tr|Q4H2S9|Q4H2S9_CIOIN Smoothened OS=Ciona intestinalis GN=Ci-smoothened PE=2 SV=1
------------------------------------------MAA------GNSTTAPSLLDLFNQQPQCNDLGNTTCFGSDLPYSQTSFELVTDADTLA
GVKEKLLLWSGIRAVPLCWDAIQPLLCSVYFPECGENKIQLIDRKVCQATRQPCKIVEVEYGWPDFLRCDNDVYADQCESPSTKLLKFNASGCEPPLMAT
TNPASYYDGVDGCGLQCMNPLFNEQQHVDMHVFIAVLAGLTCICTLFAMLSFFVDWKNSNKYPARIIFYINLCFFMACIGWLAQFFSNARNEIVCRRDGT
MRLGEPVGGESPSCIVIFVLVYFFLMAGIIWFDILSYSWFIMYKALNTRKDPLVGKTRKFHLAAWCIPFVLVLACLGVSQVDGDSMSGICFIGYKNHMYR
VGFLLVPVGLVLFIAGFFLLRGLAALFSLKNQQSGLLSDSAVSKITWTMARIGIFTFIAFVFVFITFAVHVYELTHQALWEASFRDFIKCEANVTILETL
SGTPVVCELHNRPSIALMKLNLVALFGTGIAMSTWVWTRASALNWRRFWFKLIGRSDNMKRIRHRSRMIAKAFANRHANLDKHDDEIEYSEHTFTHQDPL
-GMNFDLHSVSQEMSSSWVRNVPNMVKRRGGMLPMEQPHDNVED------QPGLWAVSQYIDGPQLKQKSKPIQKRNTKLKSTFIGTPYNLPKQQIPPGV
LPTLPE---------------------------------------------------------------------------------
>tr|G1T4W7|G1T4W7_RABIT Uncharacterized protein (Fragment) OS=Oryctolagus cuniculus GN=SMO PE=4 SV=1
--VPGSPQRGPLGKPTLALLLP-SRPSRPSRPSPSSSPGGRAWLGAAARRSAAATG-PPLLSRCGRAAHCEPLRYNVCLGSALPYGATSTLLAGDSDSQE
EAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLYTEAEHQDMHSYIAAFGAITGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHASFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPT
KKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEHANLWLVEAEISPELEKRMGRKKKRRKRKKEVCPLGPPPELHRPAPSTSA
VPRLPQLPRHKCLVAAGAWGTGEPSRQGAWTLVSSPFCPESSLRQDPFLPSVPAPWAQGRRQGL--GPMHSRTNLMEAELMDADSDF
>sp|O42224|SMO_CHICK Smoothened homolog (Fragment) OS=Gallus gallus GN=SMO PE=2 SV=1
--------------GPCWLW-----ALALG----LAL---------PRRCPAAPLNAAAPPERCRRPAACERLRFGSCLGSALPYAHTSTLLAADSGSQE
EAHGKLLLWSGLRNAPRCWDVIQPLLCAVYMPKCEDGQVELPSQTLCQATRAPCTIVERERGWPDFLKCTPDRFPEGCPNEVQNIKFNSSGQCEAPLVRT
YNPKSWYEDVEGCGIQCQNPLFTETEHREMHVYIA-FSSVTISCTFFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGCVAQFMDGARDEIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLITWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREYVLCEANVTIATQT
NKPIPECEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWKRTWCRLTGQSDDQPKRIKKSKMIAKAFSKRKELLRDPGRELSFSMHTVSHDGPV
AGLAFDINEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEERSNLWVVEADVSPELQKRSRKKK-RRKKKKE--EVCP--RG-----TPSS
VPRLPRLPQQPCLVAIPLWDGR--RRAHVPHFITNPFCPESGSPED-------GSV-RTRGRRAGLAPIHSRTNLVNAELLDADLDF
>tr|K7FHS6|K7FHS6_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=SMO PE=4 SV=1
----------------------------------------------------------------------------------------------------
-SHGGFLPRPGLRNAPRCWDAIQPLLCAVYMPKCEDGQVELPSQTLCQATRGPCTIVERERGWPDFLKCTTDRFPEGCPNEVQNIKFNSSGHCEAPLVQT
DNPKSWYEDVEGCGIQCQNPLFTESEHRDMHVYIAAFSSVTIFCTFFTLATFVADWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARGEIVCRAACP
V--PLPSSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLVTWAIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGKRGPGGPGL-WGTAGVHALSGCTRESWGGRWLSWCPPSGSVTARIHT
NKPIPNCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWKRTWCRLTGQSDDEPKRIKKSKMIAKAFSRRKELLHNPEQELSPLAPQISLTFVP
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATP-----ESYAWWD--SRGGELGGSGRGRKKKRRKKKEAGPPGPPQLV-----ARSA
VPRLPKLPRQKCLVSSP------------------------------------SVG-RTPGRRAGFAPVHSQTNLMDAELLDADSDF
>tr|R4GD86|R4GD86_ANOCA Uncharacterized protein OS=Anolis carolinensis GN=SMO PE=4 SV=1
-------MGLALGGVVAWACLC-LGPLGGSGAWGASI-----PANGSGR----ASQKAETEARCKREAPCEPLEQSLCLGSPLPYAATSTLLAEDSASQA
QARHKLLLWSGLRNAPRCWDVIQPLLCAVYMPKCEGGKVELPSQTLCQATRGPCTIVERERGWPDFLKCSTDRFPEGCPNEVQNLKFNTSGQCEAPLVRT
DNPKSWYEDVEGCGVQCQNPLFTLTEHQQMHRYIAAFSSITIFCTFFTLATFVADWKNSNRYPAVILFYVNACFFMGSIGWLAQFMDGARMEIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLLTWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLLVGGYFLIRGVMTLFSIKNNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREHVLCEANVTIATET
KKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWKRTWGRLTGRSGDEPKRIKKSKMIAKAFSKRKELQNNPNQELSFSLRTVSHEGPV
AGMVFDINEPSGDVSSAWAQHVTKMVARRGAILSQDVSVTPVATPVPPEERASLWLAEDERRRKKTSRKAKKTKRRKRKE-VSPSRMTDNP-----FVSS
VPRLPRLPEAKRFVSSPAYRCPNADHFSRRNPISHPFCPDDAGQPEGPLPQHPS-WFQTQARRGPLPPIHSRTNLMDAEVLDLDSDF
>tr|A0A0Q3XTV4|A0A0Q3XTV4_ALLMI Smoothened, frizzled class receptor OS=Alligator mississippiensis GN=SMO PE=4 SV=1
MMA----------GRWALLCL--LLALALG----LSP---------ARGAQ----LNTPAPERCKRVAPCERLHYNACLGSTLPYAATSTLLAGDSGSQE
EAHGKLLLWSGLRNAPRCWDVIQPLLCAVYMPKCEDGKVELPSQTLCQATRGPCTIVERERGWPDFLKCGLDRFPEGCPNEVQNIKFNSSGQCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLFTEWEHHEMHVYIAAFSSVTIFCTFFTLATFVADWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARGEIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLVGKTSYFHLVTWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREYVLCEANVTIATQT
NKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLLIWRRTWCKLTGQSDDEPKRIKKSKMIAKAFSKRKELLHNPEQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISITPMATPVPPEDRPNLWVVEAEISPELEQRSNRRKKRRKKKKDVCPLGPPLPG-----ASSS
IPRLPQLPRQTCLVAGPYFPRDH-RYPGMLHLINNPFCPESGLQEE-------LDG-RTQGRQAAFAPGHSRTNLVDAELLDADSDF
>tr|F7EBW1|F7EBW1_XENTR Uncharacterized protein OS=Xenopus tropicalis GN=smo PE=4 SV=1
MS-----------SMVPWICW--IGGFAFL----LVI---------TS---AGVQINTFYMDKCKKTTTCEPLKYNVCLGSVLPYALTSTVLAEDSSTQE
EIHDKLLLWSGLRNAPRCWDAIRPLLCAVYMPKCEGGKVELPSQSLCQTTRVPCAIVARERGWPDFLKCTTDHFPDGCSNEIQTVKFNSSGQCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLFTKKEHREMHVYIAIFSSVTIFCTFFTLATFLSDWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARDEIVCRGDGT
MRLGEPTLSETVCDVLLLSVVIGLLDSEILVLFVKSVNFNLTARAFKTGYRLICGQRSDFRSIDGTVYKCLSVDVIKISLVDGDSVSGICFVGYKNYHYR
AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAEQT
NKPIPECEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRILGRSDDEPKRIKKSKMIAKAFSKRKELLNNPEKELSFSLHTVSHEGPV
AGLNFDINEPSADMSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEER-EQWLIEGDLPQGMVKKMSKKKRRRKK-KEI---QPEENM-----ANTA
VPRLPKLPLKTGLVTRSYYPVESYTRYPQSNMMSHPFAADKMPHTD-------LTS-RTQARRAGIPPMHSRANLMDAELMDTDSDF
>tr|Q98SW5|Q98SW5_XENLA Smoothened OS=Xenopus laevis GN=Smo PE=2 SV=1
MS-----------SMVPWICW--IGGFGFL----LFI---------TS---GGVQINTFYMDKCKKTTTCEPLKYNICLGSVLPYALTSTVLAEDSSSQD
EVHDKLSLWSGLRNAPRCWDAIRPLLCAVYMPKCEGGKVELPSQGLCQTTRVPCAIVARERGWPDFLKCTTDYFPEGCPNEVQNIKFNSSGQCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLFTNKEHREMHIYIAIFSSVTIFCTFFTLATFLADWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARDEIVCRGDGT
MRLGEPTSNETLSCVIIFIIVYYSMMSGVIWFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLITWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYHYR
AGFVLAPIGLVLIGGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAEQT
NKPIPECYIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRILGRSDDEPKRIKKSKMIAKAFSKRKELLNNPEKELSFSLHSVSHEGPV
AGLNFDMNEPSADMSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEER-DQWFIEGDIPQGMVKKMSKKKKRRKK-KEI---QPEAKK-----ANTA
VPRLPKLPLKTGLVTRSYYPVEGYTRYPQSNMISHPFAADKMPLTD-------LTR-RTQPRWTENPPMHSRANLMDAELMDTDSDF
>tr|H2ZZD7|H2ZZD7_LATCH Uncharacterized protein OS=Latimeria chalumnae PE=4 SV=1
----MSSRGEAVKMLLLWGCL---LLGCRP---------------------GRAQENSFALDECRRPAGCEPLKYNSCLGFPLPYRHTAISLAEDSGSQE
EIHHKLLLWSGLRNAPRCWEVIQPLLCAVYMPKCESGKVELPSQILCQATRGPCAIVQRERGWPDFLKCTTDRFPEGCPNEFQSIKFNSSGRCEAPLVRT
DNPKSWYEDVEGCGIQCQNPLFTLGEHQDMHVYIAVFGSITIFCTFFTLATFVADWKNSNRYPAVILFYVNACFFIGSIGWLAQFMDGARKEIVCRADGT
MRLGEPTSNETLSCAIIFVIVYYSLMSGVIWFVMLTYAWHTSFRALGTTYQPLMGKTSYFHLVTWSVPFVLTVAILALAQVDGDSVSGICFVGYKNYHYR
AGFVLAPIGLVLVIGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGILAFGFVFITFGCHFYDFFNQAEWEKSFREYVLIFLNVNFSDMR
KAVTACCGLR---SFSVPEINCFFLTAMHVRESVWDFSFFFFFFFFCIMAKIIGRSDDEPKRIKKSKMIAKAFSKRKELLQNPEKELSFSMQTVSHDGPV
AGLNFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEKKNLWVVEAEIPPELHKKAGKKKKKRKRKKEVQPMDEPHV------VSSN
VPRLPKLPGQKSLVSKVFYEGRFYKRHTTLNLIANPLSDEEVPQMESAVPEAERLVPTQTRRAVELAPIHSRTNLMDAELMDADSDF
>tr|Q4SQ56|Q4SQ56_TETNG Chromosome 19 SCAF14535, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis GN=GSTENG00014513001 PE=4 SV=1
---------------------------------------------------------------CKKSTTCEVLKYNTCLGSPLPYTHTSMILAEDSSTQE
EAIEKLTMWSGLRNAPRCWSVIQPLLCAVYMPKCENGRVELPSQSLCLATRRPCSIVEQERGWPNFLKCD--HFPVGCSNEVQKLKFNTSGQCEAPLVKT
DIQSSWYKDVEGCGIQCDNPLFTEEEQRRHACVHRLLRHHHA---------FSGRLEEFQPLPGCHP-LLHQRLLLRGQHWLAGPVPGWGS---------
QRDRVQESSETLSCVTIFIIVYYSMMSGVTWFVMLTYAWHTSFKALGTTQQPLSGRTSYFHLATWSIPFVLTVAILATAQVDGDSVSGICFVGYKNYRYR
AGFVLAPIGVVLVVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREYVLCEANVTIASQT
NKPIPQCVIKNRPSLMVEKINLFSMFGTGIAMSTWVWTKATILIWKRTWCKIIGRSDNEPKRIKKSKMIAKAFAMRKELHKDPEKEMSFSMHTMSHDGPV
AGINFEINEPSNDMSSAWARHVTKMVARRGAILPEDISVTPTGTPVPPPERNRLWMVEAEISPEMIKRKKKKKKRKKE------VRPEEPH-----GRSA
APRLPKLPDHPALVANLCEGFPYCSNT----LLSDHLTPNDPPED--------RTMALPPARRAYNGPVHSRTNLMEAELMDADSDF
>tr|I3K0M9|I3K0M9_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100710492 PE=4 SV=1
---MSSKSWSPVGMLCVWAAW--LSGCGAV----------------------LSP-NTIFEDTCKKTTTCEVLKYNTCLGSPLPYTHTSLILAEDSSTQE
EAFEKLTMWSGLRNAPRCWSVIQPLLCAVYMPKCENGRVELPSQSLCLTTRGPCSIVDRERGWPSFLKCD--KFPVGCSNEVQKLKFNTSGQCEAPLVKT
DIQSSWYKDVEGCGIQCDNPLFTEEEHNDMHAYIAYFGTITLLCTFFTLATFLADWKNSNRYPAVILFYINACFFVGSIGWLAQFLDGAREEIVCKSDNT
MRLGEPSSSETLSCVTIFIIVYYSLMSGVIWFVMLTYAWHTSFKALGTTHQPLSGRTSYFHMVTWSIPFVLTVAILA--EVDGDSVSGICFVGYKNYRYR
AGFVLAPIGVVLVVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFRDYVLCEANVTIASQT
NKPIPECTIKNRPSLMVEKINLFSMFGTGIAMSTWVWTKATILIWKRTWCKIIGRSDNEPKRIKKSKMIAKAFAMRKELHKDPEKELSFSMHTVSHEGPV
AGINFDLNEPSNDMSSAWAQHVTKMVARRGAILPQDISVTPTGTPVPPPERNRLWMVEAEISPEMIKRKKKK-KKRKKE--V---RPEEMHY----GRSS
VPRLPKLPPHPSLVANLYEKCPYYGHS----MLSDPLTFRDRPED-D------RMVAVPAGRRAGYGPIHSRTNLMEAELMDADSDF
>tr|W5KQ98|W5KQ98_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
FSSSSSRRLRSVGMLCLWAAT--FVGTRAV----------------------MLPKNTVFNDFCKKSSTCEALKFNTCLGSPLPYTHTSLSLAEDSQTQE
EVLEKLAMWSGLKNAPRCWAVIQPLLCAVYMPKCENGKVELPSQKLCFSTRQPCSIVEQERGWPNFLKCENESFPVGCQNEVQKLKFNTSGHCEAPLVKT
DIQASWYKDVEGCGIQCDNPLFTEEEHTDMHSYIAIFGSVTLLCTFFTLATFLADWKNSNRYPAVILFYVNACFFIGSIGWLAQFMDGARKEIVCKSDNT
MRLGEPSSTETLSCVIIFIIVYYSLMSGVIWFVMLTYAWHTSFKALGTTQQPLSGKTSYFHLITWSIPFILTVAILA--EVDGDSVSGICFVGYKNYRYR
AGFVLAPIGVVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERSFREYVLCEANVTIAHET
NKPVPECAIKNRPSLLVEKINLFSMFGTGIAMSTWVWTKATILIWKRTWCRIIGRSDDEPKRIKKSKMIAKAFSKRKELQKDPEKELSFSMHTVSHEGPV
AGINFELNEPSADMSSAWAQHVTKMVARRGAILPQDISVTPTGTPVPPPERHRMWMVEAEISPEMMKRKKKK-KKRKKE--VRPVAPEETPP----GASA
VPRLPKLPGHRSLVANLFDRYDRCSGSEPPYSLANPLTLRDSHRE-H------STPTRSDGRRAVIAPIHSRTNLMEAELMDADSDF
>tr|A0A0N8JZU2|A0A0N8JZU2_9TELE Smoothened-like OS=Scleropages formosus GN=Z043_110888 PE=4 SV=1
----------------------------------------------------------MLGDPCERRATCEALKYSTCLGSPLPYTHTSLELAMDSRSQE
EVHEKLTMWSGLRNAPRCWAVVQPLLCAVYMPKCDGGKVELPSQSLCQATRGPCAIVDQERGWPDFLKCD--KFPVGCQNEVQKIKFNTSGNCEAPLVKT
DNQKSWYKNVEGCGIQCNNPLFTEEEHSDMHVYIAAFGSITLLCTFFXXXXCSSNWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARTEIVCKSDHT
MRLGEPSSTETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTHQPLSGKISYFHLVTWSIPFVLTVAILA--EVDGDSVSGICFVGYKNYYYR
AGFVLAPIGLVLIIGGYFLIRGVMTLFSIKSKHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQEEWERSFREYVLCEANVTIAHQT
NKPIPECTIKNRPSLLVEKINLFAMFGTGIVMSTWVWTKATVLIWKRTWCRIIGRSDDEPKRIKKSKMIAKAFAKRKELQKDPERELSFSMHTVSHDGPV
AGINFDLNDPSGDMSSAWAQHVTKMVARRGAILPQDISVTPTGTPVPPDDKNHFYMVEVEISPEMLKKKKKKKKKRKKKKDSRVQGPEVM-T----GPST
VPRLPKLPGTRSLVANAFERYGR-----------NALDG----ED-E------ASYLRTQGRRAELVPIHSRTNLMDAELMDADSDF
>tr|W5NGA6|W5NGA6_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
--KMS-SRGYSVEMLWVWGAY--FLLSHLG----------------------TAQKNTGFNDYCKKTSTCEALKYNTCLGSPLPYSYTSVILAEDSSSQE
EALEKLALWSGLRNAPRCWAVIQPLLCAVYMPKCDNGKVELPSQSLCQATRSPCAIVERERGWPDFLKCTIDRFPVGCQNEVQKIKFNTSGHCESPLVKT
DNPASWYEDVEGCGIQCNNPLFTDEEHSDMHVYIAVFGSITLFCTFFTLATFVADWKNSNRYPAVILFYVNACFFIGSIGWLAQFMDGARKEIVCKSDDT
MRLGEPTSTETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLTGKTSYFHLITWSIPFVLTVAILA--QVDGDSVSGICFVGYKNYRYR
AGFVLAPIGLVLLIGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMVRLGIFGFLAFGFVFITFGCHFYDFFNQEEWERSFREYVLCEANVTIAVQT
NKPIPECAIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATVLIWKRTWCRIIGRSDDEPKRIKKSKMIAKAFSKRKELLQNPEKELSFSMHTVSHDGPV
AGINFDLNEPSVDMSSAWAQHVTKMVARRGAILPQDISVTPTGTPVPPDDKNQLWIVEAEIPPELHKKKKKR-RRRKKE--VRPLGPEEIM-----ASSA
VPRLPKLHGHRSLVANRFERYPAYRRHA--LSLIAG---PGPQDD-V------GACARTPGRRADLAPIHSRTNLMDAELMDADSDF
>tr|Q90X26|Q90X26_DANRE Smoothened OS=Danio rerio GN=smo PE=1 SV=1
---MSSKRPCSVGMLWIWTAT--SMVARAV----------------------ILHPNTIFNDFCKKSTTCEVLKYNTCLGSPLPYTHTSLILAEDSETQE
EAFEKLAMWSGLRNAPRCWAVIQPLLCAVYMPKCENGKVELPSQHLCQATRNPCSIVERERGWPNFLKCENEQFPKGCQNEVQKLKFNTSGQCEAPLVKT
DIQASWYKDVEGCGIQCDNPLFTEDEHSDMHSYIAVFGTITLLCTFLHLATFLADWKNSNRYPAVILFYVNACFFIGSIGWLAQFMDGARNEIVCKSDNT
MRLGEPSSTETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLVTWSIPFILTVAILA--QVDADSVSGICFVGYRYYEYR
AGFVLAPIGFVLVIGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAHQT
NKPIPECAIKNRPSLLVGKINLFSMFGTGIAMSTWVWTKATILIWKRTWFRIIGRSDDEPKRIKKSKMIAKAFSKRKELQKDPEKELSFSMHTVSHEGPV
AGINFDLNEPSIEMSSAWAQHVTKMVARRGAILPQDISVTPTGTPIPPPERNKLWMVEAEISPEMMKRKKKK-KKRRKE--VRPAGPADENY----GPSA
VPRLPKLPGHRSLVANLFDRYGGYLRNPSSLPLANPLTLRDSMQ--A-------VTAVPRADGRRGVQIHSRTNLMDAELLDADSDF