>seq_1
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDG
RGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
QVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE
RTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
>tr|G1N7U9|G1N7U9_MELGA Uncharacterized protein (Fragment) OS=Meleagris gallopavo GN=FZD7 PE=4 SV=2
---------------VPPLTALLAALLGTPCAAAHQDDKAISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKF
FLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAPPGPGGGATVQPTAGYLPDLT---------PP
QPATGFSFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRPNGLMYFKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAYAAGFLLEERVVCLERFSEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
QVDGDVLSGVCYVGIYSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGT-----------------------------------------
--------------------------------------------------------------------------
>tr|A0A088APN5|A0A088APN5_APIME Uncharacterized protein OS=Apis mellifera GN=LOC100576247 PE=4 SV=1
----------------------------------------AGVNGNGRCEEITIPMCRGIGYNLTAMPNELNHDNQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICLPYTKPLPACRSVCERARAGCAPLMQQYGFSWPERMACERLPAHGDPELCMEQDNHTSSTGHGGSGG-SAP---LPAQP-RPRP--S---
KTQKNCARDCVPPLAG---LMADIAGVPNCALPCHG------AFLTSEERGFAAVWLALWSGLCAASTLVTVTTFLIDTQRFKYPERPIVFLSACYFAVS
IGYLSRSVFGHEEIACDGSA---LKSRAQG--PEACVAVFLMIYFFGMASSVWWVILAFTWFLAAGLKWGNEAIASYSQYFHLAAWLAPAVQTFSAYLAG
GVAGDPVAGVCTV---APDGVRSFILVPLFVYLLLGTSFLLAGFVSLFRIRSVIKRQPAKADKLEKLMIRIGVFSVLYTLPAGVVLACHMYETSLRNEWL
D--------SLACPCR----PRARPLYSVLMLKYFMALAVGITSGVWIWSGKTVDSWKRLWRRLFSGGG-----
>tr|K7JBY1|K7JBY1_NASVI Uncharacterized protein OS=Nasonia vitripennis GN=LOC100114419 PE=4 SV=1
----------------------------------------LSSPTGSRCEEITIPMCKGIGYNLTTMPNELNHDTQDEAGLEVHQFWPLVEIKCSLDLKF
FLCSMYTPICLPYSKPLPACRSVCERARMGCAPLMHQYGFSWPERMACERLPNQGDPELCMEQDNRTTLVSTE-------I---LTIALPKPKT--P---
KGQKNCEKDCTPPL-----QAAESLGSLNCVLPCQG------AFLTNEQKNFATIWLTLWSGLCAASTLATVTTFLIDTQRFKYPERPIVFLSACYFLVS
IGYLSRSIIGHEQIACDGNM---LRYGTQG--PGICITVFLLIYFFGMASSVWWVILSFTWFLAAGLKWGNEAISSYSQYFHLAAWLAPTAQTLWALLAG
GVAGDPIAGVCTV---APEGIRIFILAPLLMYLLLGTTFLFAGFVSLFRIRSVIKRQPAKADKLEKLMIRIGVFSVLYTVPASAVLACHLYETTLRSEWL
S--------SLACPCK----PRIKPLYSVLMLKYFMALAVGITSGVWIWSGKTIGSWKRLWRRLFGRNL-----
>tr|E0VGL1|E0VGL1_PEDHC Class D atypical G-protein coupled receptor GPRfz2, putative OS=Pediculus humanus subsp. corporis GN=Phum_PHUM188130 PE=4 SV=1
-------------------------------------------------------MCRGIGYNLTSMPNELNHESQEEAGLEVHQFWPLVEIGCSPDLKF
FLCSMYTPICIEYHKPLPACRSVCERAREGCTPLMLQYGFPWPERMACERFPIHDDPELCMEQSNRTDSTKSQQSS----------SATHKPKKNSCV--
GK----GSDCVPPL------SISVGNVNNCGFPCHG------VFFNQEEKDFASVWITLWSSLCCVFTLMTLTTYFIDTERFKYPERPIVFLSACYFLVS
VGYLIRVVLGHEEVACEAKM---IRYNATG--PIPCTVVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGNEAIAGYSQYFHLAAWLIPTVKSIAVLVMN
AVDGDPVAGICYVGNQNSDNLRGFVLVPLLVYLLLGTSFLLGGFVSLFRIRRVIKQQGSKADKLEKLMIRIGIFSVLYTVPATIVIGCHIYESTFYTNWM
S--------QLVCPCSEPLRTRLRPMYWILMLKYFMALAVGITSGVWIWSGKTLDSWRRLSRRLFGGGR-----
>tr|T1HKP7|T1HKP7_RHOPR Uncharacterized protein (Fragment) OS=Rhodnius prolixus PE=4 SV=1
----------------------------------------VTSHSGPRCEEITIPMCRGIGYNLTSMPNELNHDSQEEAGLEVHQFWPLVEIRCSPDLKF
FLCSMYAPICIEYHRPLPACRSVCERARSGCAPLMQQYGFQWPDRMACEKLPVHGDPDLCMEMDNRTSQEQKTTK---------------KPIVQQCG--
R-----DKDCTPPF------SVSVAGVPNCAFPCLR------SFFSPEERQFAHIWITLWSSLCCVSTLMTLTTFLIDTERFKYPERPIVFLSACYFMVS
IGYLTRSVLGHEEVACDGAT---LSYHASG--PTPCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGNEAIASYSQYFHLFAWLVPTVMSVGVLVMS
GVDGDPVGGICYVGNTDPANLRMFVLGPLLLYLLLGTSFLMGGFVSLFRIRNVIKQQGSKADKLEKLMIRIGIFSVLYTVPATIVIGCLVYEHSAQEQWL
S--------SIICPCKE---PHPRPLYSVLMLKYFMALAVGITSGVWIWSGKTLGSWRRLWGS-----------
>tr|A0A067RPY7|A0A067RPY7_ZOONE Uncharacterized protein (Fragment) OS=Zootermopsis nevadensis GN=L798_02601 PE=4 SV=1
-----------------------------------------------RCEEITIPMCRGIGYNLTSMPNELNHDTQEEAGLEVHQFWPLVEIHCSPDLKF
FLCSMYAPICIEYLRPLPACRSVCERARNGCVPIMKQYGFQWPERMACEKFPVHGDPNLCMEQNNRTDSGPTTTA---------------RPRKPTC---
----------PPPL------SVSVGKVQNCAFPCRG------AFFTQEEKDFASVWIALWSGLCFFSTLMTLTTFLIDT--------------------D
IGYLVRVFMGHEEVACEGGM---IRYSSTG--PVTCTMVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGNEAIAGYSQYFHLAAWLIPTVKSVGVLITA
AVDGDPVAGICYVGNQNTDNLRGFVLTPLVVYLVVGTSFLLGGFVSLFRIRNVIKQQGSKADKLEKLMIRIGIFSVLYTVPATVVIGCHLYETTLYAEWM
N--------PLVCPCEAMPRSRLRPLYSILMLKYFMALAVGITSGVWIWSGKTLDSWRRLSRRFFGGSG-----
>tr|A0A0A9X185|A0A0A9X185_LYGHE Frizzled-2 OS=Lygus hesperus GN=fz2 PE=4 SV=1
----------------------------------------VTSGGGPRCEEITIPMCRGIGYNLTSMPNELNHDTQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYAPICIEYHQPLPACRSVCERARSGCAPLMQQYGFQWPERMSCEKLPVHGDPELCMEMDNRTEAKPTKRP------------------APTCG--
R-----DRDCSPPL------SVSVAGVPNCAFPCKE------EFFSPEEKEFANVWITLWSSLCCISTLMTLTTFLIDTERFKYPERPIVFLSACYFMVS
VGYLTRVVLGHEEVACDGPM---LRYHASG--PTPCTLIFLLVYFFGMASSIWWVVLALTWFLAAGLKWGNEAIASYSQYFHLCAWLVPTVKSVGVLVMS
GVDGDPVSGICYVGNTNPENLRIFVLGPLLLYLLLGTSFLLGGFVSLFRIRNVIKQQGGKADKLEKLMIRIGIFSVLYTVPATIVIGCLVYETTVHDEWM
S--------GLTCPCKE--RPKIRPLYSLLMLKYFMALAVGITSGVWIWSGKTLGSWRRLWGRLCGVPP-----
>tr|N6T4T2|N6T4T2_DENPD Uncharacterized protein (Fragment) OS=Dendroctonus ponderosae GN=YQE_08262 PE=4 SV=1
----------------------------------------SSLEAEGKCEEITIPMCLGIGYNMTRMPNELNHESQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYAPICLPYSKPLPPCRDLCRRAREGCEPIMTQYGFEWPERMECDQFPKQG--ELCMDQPTHNTSSTPRP-----------------TRKPLC---
--SKNCPNECRQPL------NRNVAGVPNCAFPCKE------TYFTTDEKEFASIWISLWSGLCAASTLMTLITFFIETERFKYPERPIVFLSACYFLVS
VGYLLRVGFGHEAVACDGPI---IRYTSNG--PSLCTLVFLLVYFFGMASSIWWVILSLTWFLAAGLKWGNEAIASYAQCFHIAAWLIPTLQTLGVLLSG
AVDGDPVSGICYVGNMNTENLQTFVLGPLVVYLILGTSFLLAGFVSLFRIRSVIKKQGSKADKLEKLMIRIGIFSVLYTVPATIVIGCHLYENAFHKEWL
K--------SLACSCFTS--NKVKPIYAALMLKYFMALAVGITSGVWIWSGKTLDSWRRLWKRLFGRPD-----
>tr|A0A0J7KX39|A0A0J7KX39_LASNI Frizzled-2-like isoform x1 protein OS=Lasius niger GN=RF55_4932 PE=4 SV=1
----------------------------------------NNNNGNGRCEEITIPMCRGIGYNLTAMPNELNHDTQDEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICLPYTKPLPACRSVCERARAGCAPLMQQYGFSWPERMACERLPNHGDPELCMEQDNRTSSST-GPGGNGAGG---APGPPARPRP--S---
KTQKNCTRDCAAPL-G---RIQEIAGVPDCALPCRG------AFLTNEEREFAAIWLALWSGLCAASTLVTVTTFLIDTQRFKYPERPIVFLSVCYFLVS
AGYLSRSIFGHEEIACDGPA---LKSGAQG--PGLCVTVFLLIYFFGMASSVWWVILAFTWFLAAGLKWGNEAIASYSQYFHLVAWLAPTVQTVWAYVAG
GVAGDPVAGVCTV---APQGVRNFILAPLFVYLLLGTSFLLAGFVSLFRIRSVIKRQPAKADKLEKLMIRIGVFSVLYTLPAGAVLACHIYESSLRDEWL
S--------SLACPCR----PRARPLYSILMLKYFMALAVGSTSGVWIWSGKTVDSWKRLWRRLFGGNR-----
>tr|A0A0C9REC1|A0A0C9REC1_9HYME Fz2_0 protein OS=Fopius arisanus GN=fz2_1 PE=4 SV=1
----------------------------------------VGSNGNGRCEDITIPMCRGIGYNLTAMPNELNHDTQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICLPYSKPLPACRSVCERARAGCAPLMQQYGFSWPERMACERLPVQGDPELCMEQDNHANSGGSGAGH-SSPP---IPAGPARPRP--S---
KTQKNCTRECEAPLGPMVSRLGNGNVLKNCALPCHG------AFLTTEERGFAAVWLALWSGLCAASTLTTVTTFLIDTQRFKYPERPIVFLSACYFVVS
LGYLARSVMGHEEIACDGPA---LKSGPQG--PGACVTVFLMIYFFGMASSVWWVILAFTWFLAAGLKWGNEAIASYSQYFHLAAWLAPTAQTVWALLAG
GVEGDPVAGVCTV---APGGVQTFILVPLLVYLLLGTSFLLAGFVSLFRIRSVIKRQPAKADKLEKLMIRIGVFSVLYTVPAGAVLGCYLYESSFRLEWL
R--------GIACQCE----ARTRPYYSVLMLKYFMALAVGITSGVWIWSGKTVDSWRRLWRRLFGGGA-----
>tr|D6WG76|D6WG76_TRICA Frizzled 2 OS=Tribolium castaneum GN=Fz2 PE=4 SV=1
----------------------------------------DGSDQEERCEDITIPMCMGIGYNQTRMPNELNHETQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYAPICLPYKKPLPPCRGLCKRAREGCEPIMTQYGFKWPERMDCEQFPVYGSPDLCMDENNGSSTTAKPP-----------------PAKAPC---
--SKNCAKGCKHPL------NLSVLDPATCAAPCRA------TYFNSEEKEFTTVWITLWSSLCAASTLMTLTTFFIETERFKYPERPIVFLSACYFLVS
VGYLIRVGVGHEEVACEGPV---IRYSSTG--ANPCSLVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGNEAIASYAEYFHVAAWLIPTLQTVAVFVSG
AVDGDPVAGICYVGNMNMENLRTFVLAPLFIYLLLGTTFLIAGFVSLFRIRNVIKKQGSKADKLEKLMIRIGIFSVLYTVPASIVIACHLYENAFHNEWM
L--------SAACTCP-S--AKVRPIYSVLMLKYFMALAVGITSGVWIWSGKTLDSWRRLWRRLFGRPD-----
>tr|A0A0Q3M2V1|A0A0Q3M2V1_AMAAE Frizzled-5 OS=Amazona aestiva GN=AAES_132282 PE=4 SV=1
----------------------------------------RAASKALVCQEITVPMCKGIGYNLTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSMYTPICLPYTKPLPPCRSVCERAKAGCSPIMQQYGFAWPERMSCDSLPVLGDTELCMGYNHTEATTLPPF---------------FGKTRPA----
--TKNLDCGRTAPL--PLYNRIRTGQVPNCAIPCYQ------PYFTQDEKTFATFWIGLWSILCFLSTSTTVATFLIDMERFKYPERPIIFLSACYLFVS
VGYIVRLVAGHANVACNPEH----HYETTG--PALCTVVFLLLYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQYFHLAAWLIPSAKSIAVLALS
SVDGDPVAGVCYVGNQSLENLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKQ-GTKTDKLEKLMIRIGIFTMLYTVPATIVIACYIYEQHNREAWE
Q--------AQNCSCPGD-PHRPRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFTARCCRARK-----
>tr|A0A0Q4A8B1|A0A0Q4A8B1_ALLMI Frizzled class receptor 5 OS=Alligator mississippiensis GN=FZD5 PE=4 SV=1
-------------------------------------------------------MCKGIGYNLTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSVYTPICLPYSKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCERLPVLGDSELCMGYNRSEATTLPPF---------------FVQTPPE----
------PCARAEPF--PLYNRARAGQVPNCAVPCFQ------PYFSADERTFAAFWIGLWAILCFLSTAATVATFLIDMERFQYPERPIIFLSACYLLVS
AGYLVRLVAGHARVACSADS----HYETTG--PALCTLVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSPYFHLAAWLLPSAKAIAVLALG
SVDGDPVAGICYVGNQSVDNLRGFVLAPLVLYLLTGSLFLLAGFVSLFRIRSVIKQ-GTKTDKLEKLMIRIGVFSLLYTVPAAAVVACHVYEQHSRERWE
R--------AHACACPGE-PPPAKPDYAVFMLKYFMGLAVGITSGVWIWSGKTLESWRRFSGQCCRSTK-----
>tr|A0A068CM83|A0A068CM83_HOFMI Frizzled-9 OS=Hofstenia miamia PE=2 SV=1
----------------------------------------VSTIDKRSCELISIDICKGLGYNLTSMPNRFNHDNQLEVGLEINQFATLIKIGCSDDLRF
LLCTQYLPPCFRYNMDLTVCRPLCERAKDGCTPVMESVGFQWPQHIACEPFPEKSTKDICMDRPNMNKTKSKSKAP------------------------
------QTKCDERL------NFTTGTVPHCALPCRA------GYFSDETSGFTTLWLGIWATTCFVSTTIMTATFLIDRARFKYPERPIIWLAICYLFIA
IGFIIRLIAGHENVACSNNK---DYEVDIN--ISTCMLVFILVYYFGMASALWWVILSFTWFLAAGLKWSSEAISQYACVYHIIAWAIPALLSIFAIILK
AIDGDSVSGLCYVGNQSDISLQVFVICPLIIFIFVGGAFLFAGFFALCRIRNVIKAGGRKTDQLEKLMARISIFSVLYTVPATVVIFCYLYELRYRGDWE
H--------GLACRCRDS---ASTPDYAIFMLKYFMSLVVGITSGFWIWTKKTINSWQTFLMRICCCSK-----
>tr|Q9PWK6|Q9PWK6_DANRE Frizzled 8b protein OS=Danio rerio GN=fzd8b PE=2 SV=1
----------------------------------------SVCGREHVCQEISVPLCRGIGYNYTYMPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSMYTPICLEYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPNLCMDYNRTDATSSPAA---------------PKTSRPG----
-----FSCEPEAPM--PLYNRVKTGQIPNCAMPCHN------PYLSQEERTFATFWIGIWSVLCFLSTFATVATFLIDIERFKYPERPIIFLSACYMFVS
LGYIIRLIAGHERVACNQNH---EHYETTG--PALCTLVFLLIYFFGMASAIWWVILSFTWFLAAGLKWGNEAIARYSQYFHMAAWLIPSVKSITVLALS
SVDGDSIAGICYVGNQNLDNLRGFVLAPLVIYLFIGTIFLFAGFVSMFRIRSVIKQ-GTKTDKLERLMVRIGVFTVLYTVVAIMIVACYVYEHHNREAWE
I--------AHACNCSSD-KKAPKPDYAVFMLKYFMCLLIGITSGAWTWSSKTLDSWRALCTRCCCCRW-----
>tr|G5C178|G5C178_HETGA Frizzled-5 OS=Heterocephalus glaber GN=GW7_17273 PE=4 SV=1
----------------------------------------AAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRF
FLCSMYTPICLPYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGDAELCMDYNRSEATTAPPR-------------SIAPKTVPG----
--APSSGGPALEPF--PLYNKVRTGQVPNCAVPCYQ------PSFSPDERTFATFWIGLWSVLCFISTATTVATFLIDMERFRYPERPIIFLSACYLCVS
LGFLVRLVVGHASVACSREH----HYETTG--PALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSIKSITALALS
SVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTPFLLAGFVSLFRIRSVIKQ-GTKTDKLEKLMIRIGIFTLLYTVPASIVVICYLYEQHYRESWE
A--------ALTCSCPGRSQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPR-----
>tr|A0A087TFP4|A0A087TFP4_9ARAC Frizzled-8 (Fragment) OS=Stegodyphus mimosarum GN=X975_02667 PE=4 SV=1
----------------------------------------SVSCQQERCEEITIPMCRGIGYNYTSMPNKFHHDTQDEAGLEVHQFWPLVEIHCSDDLLF
FLCSLYAPICIEYQGQLPACYSVCDRARAGCAPIMHKYGFVWPERMNCDDFPRYGDQELCMDAKEGAGPENGEYNSQ--------EKPVRRPSYRGSSD-
--GKAGDSECSFPM--RLYNNVATGGVPHCARPCRG------TFFSKDEQTFAAFWIGLWAIFCCVSASMTVLTFLIDPTRFRYPERPIIFLSGCYLMVS
VGYLVRLGLGHEAVACDGPI---VYHTTGR--PPACTIVFLLIYFFGMASSLWWVILTLTWLLAAGLKWGNEAIAGYSQYFHLAAWLVPTGKSIAVLAMG
AVDGDPVAGVCSVGNQNVDYLRWFVIMPLCAYLLLGTSFLLAGFVSLFRIRNVIRQQAAKADKLEKLMIRIGVFSVLYTVPATIVIGCHFYEQHFRERWD
H--------RHNCPCESD---TARPDYSVFMLKYFMCLVVGITSGFWITSVKTLESWRQRLCRRRGQRG-----
>tr|B7PAJ1|B7PAJ1_IXOSC Transmembrane receptor, putative (Fragment) OS=Ixodes scapularis GN=IscW_ISCW003177 PE=4 SV=1
-----------------------------------------------RCEDITIPMCKGIGYNQTSMPNQFNQDTQDEAGMEVHQFWPLVEIQCSDDLKF
FLCSLYTPICMEYAGSVPACRSVCERARAGCAPIMRQYGFAWPERMNCDALPQYGDQELCMDAKEGARPDTADSNL-------------AVPRLPG----
------MSECEAPL--HFYSRGMWSRPPECALPCRM------VYFNGYDQTFATYWISTWAVLCCVSTSVTVLTFLMDTARFRYPERPIIFLSFCYLMVS
VGYLIRLAMGHEPIACDGNV---VYYVNSR--PFACTLVFILLYFFGMASSMWWVILTLTWLLAAGLKWGNEAIAGYSQYFHIVAWAVPTIKTIVAVLLS
AVDGDSVAGVCYVGNQDLANLRGFVLGPLCLYLLLGTSFLLAGFVSLFRIRSVIRAQAAKADKLEKLMIRIGIFSVLYTVPATVVIACYFYEHHYREPWL
R--------RLRCPCPRN-NEAPRPHFFMFMVKYFMCLVVGITSGFWIWSGKTLESWWNFYARLCGGRR-----
>tr|W5JKJ4|W5JKJ4_ANODA Frizzled OS=Anopheles darlingi GN=AND_003589 PE=4 SV=1
----------------------------------------VPRDPNSRCEEITIPMCRGIGYNLTSFPNEMNHETQEEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICIEYHKPLPVCRSVCEKARAGCAPIMQQYSFSWPERMACENLPVSGDADLCMEMPNEDDHGDHHRGGSG----GGGAGGGGKPRKSHGGGG
SGSKNCTKECMEPLPNTISSVERVGDVQNCAIPCRG------AFFTQEEKDFAGIWIALWSGLCGISTLMTLTTFLIDTERFKYPERPIVFLSACYFIVS
CGYLTRLFLGHDEIACDGRS---IKYPSTG--QSSCTMIFIMVYFFGMASSIWWVILSFTWFLAAGLKWGNEAISKHSQYFHLAAWLIPTVQTVSVLLRP
AVDGDPVAGICYVGNTSVEHLKTFVLAPLFMYLVVGTTFLMAGFVSLFRIRSVIKQQGSKADKLEKLMIRIGIFSVLYTVPATIVIGCHLYEASYFEDWM
T--------GLTCPCKMAPGLRQKPLYSVLMLKYFMALAVGITSGVWIWSGKTVDSWRRLWRRLFGSPD-----
>tr|Q29DI2|Q29DI2_DROPS Uncharacterized protein OS=Drosophila pseudoobscura pseudoobscura GN=Dpse\GA21999 PE=4 SV=3
----------------------------------------IPKDPNSRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICLEYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDLCMEQPSYTEAGGSGGSSGGSGGAGSGSGSGGK-RKQGSGGS
GGSKNCGKECASPLHHHWYMVQRIAGVPNCAIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVA
VGYLSRNFLQNEEIACDGHL---LKESSTG--PHSCTLVFLLTYFFGMASSIWWVILSLTWFLAAGLKWGNEAITKHSQYFHLAAWLFPTVQSVAVLLLS
AVDGDPILGICYVGNLNPDHLKKFVLGPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWI
K--------ALACPCAQVKGPGRKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLFGAPD-----
>tr|S4RE68|S4RE68_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
-------------------------------------------VRPAACEPLAYSSCAALPYAQTALVLASDSHSQHDAQANLQLWAGLSVPRCWEVVQP
LLCAVYMPRCSA-GAVELPSRALCHATRAPCAVVART-PHGWPDFLSCQ-PERFP--DGCPN-TVQGVHFNTTS--------------------------
--------SCAAPLVRTDNPASWVRDVEGCGLPCS----S--PLYTAEEHAAMRTATAAMGALALLSEIFTLATFVGDQRSRRYPAVVICYINACFLVAS
AGWLAQFSDARDITCRHDGTPRVGEPT--SSETLSCVIIFVLIYYPLMAAVCWFVCLAYAWNASFRALTPQRPLARKTSYFHLACWSLPFVLTVAILALQ
QVDGDSMSGVCFVGYRDPHFRAGFVLAPVGVATVAGGYYLACGMFTLFRIRRSHPGLLKASTKIQETIVRLGVFGVLAWGFVLLTFGCHIYDFLHREQWQ
RSLSYILCRSNPRKCE----LGARPGLLLAVGNVACVFGTGITMSSWVWTRATLHTWRHTWLRI----------
>tr|A7S829|A7S829_NEMVE Predicted protein OS=Nematostella vectensis GN=v1g208236 PE=4 SV=1
-------------------------------------------QGSYKCEPLKEQTCEKLDYHYTTTELVTDSSSQDQVKKNLEKWEGLFLPKCWEVLQP
FLCQIYKPKCKN-GSVELPCREQCFATRKPCSVVES--YRRWPEFLRCD-KL-PE--GNCNG-TLKKLHLNE-S--------------------------
--------ACKAPLVETAYKPSWYEGIEGCGIQCM----N--PIFSEEEHTRIHRFVAAFGTLTTVCTLFTVVTFLVGKSQNRYPSVILFFMNACFCVAS
VGFLIQFSDARKVVCRRDDTMRLGEPT--ESDSFLCVLTFVLVYYFSLAGMTWFVMLAYSWCICFKTLSTRDNFAGKTGYFHIISWSLPAVLTGCVLLVK
QVDANSISGICFVGYKNPSMRAGFLLAPLGLDLVIGGMFLAKGLFTLFKLRKSNPNFLRASIKIKETIMRVGFFAFVAFAFVFITFACHVYEYYNQERWE
RSYRFLMCIANSNTCS----IKDRANLSVLELSLSSLFGAGIAMSGWTWTSNTFKTWKKLWHRV----------
>tr|S4PKF0|S4PKF0_9NEOP Smoothened (Fragment) OS=Pararge aegeria PE=4 SV=1
-------------------------------------------VRRAQCETLNKTTCAKLPYNTTSVQLTF-YDSQYQIQNQLELYRELNVPKCWAVVQP
LLCATFMPNCEHIDMVYLPSYEMCKITMEPCAILYN--TSYFPYFLKCN-ATLFP--PKCEN-VAREMKFNTTG--------------------------
--------KCLPPLIHTDKAPHFYEGISGCGLPCR----D--PLYTEDEHQQIHRLVAWGAGVCLALNLMTVATFLIDRSANKYPALVIFYINVCFAVAS
MGWLVQFVGSRDIVCSKDGTRRQGEPS--AEENLSCVVVFVLVYYFMIAACVWFVIFTYAWHMSFRALKIQDRIDKKAAYFHLVAWSLPLILTITTMAFG
EVDGNSVTGVCFVGYVNHPMRAALLLAPLSVVLLLGGYFLLRGVFSLIAVRVSSKDVIRAANKIRQTITRCSLTAALVAVFICVTFACHIYEFRNAESWK
EAFKNIICRL-GRECA----GGARPSVSVLQLRLLCCFAAGALMASWTWTPAAAA-------------------
>tr|A0A0A9ZBZ1|A0A0A9ZBZ1_LYGHE Protein smoothened OS=Lygus hesperus GN=smo_0 PE=4 SV=1
-------------------------------------------LKPAKCEFMNYTTCTKLPYNYTSLDLVDGVSTQQQAQEQLNEWQRLHVPKCWAVIQP
FLCALYMPRCDSPQVVSLPSQEMCKMIQGPCRIVTT--YEQWPSVFRCENNTRYP--TMCKN-DVRELKFNSTG--------------------------
--------QCMSPLVPTDHPSWFFEGVEGCGVQCN----D--PMFPDHDRQYIHKMVFGAASLCALFNLFAVLTFMIDKFSSKYPALVIFYINYCFLMVC
LGWLAQFPGGRDIVCRKDGTLRLGEPS--ASENLSCVIVFVMVYYFLMAGVAWFVILTYACHISLQALKIQECMEKKAAYFHMVAWSFPLVLTIATMALG
EIDGNSVTGICFVGYANDEYRAGFLLVPVAIALAVGTAFLFKGLFTLIRLKVDSEDIIRASSKIRETIFRMVVFSFLILIFGGITFTCHIYEFMNNEKWA
KSFRYVLCKL-SSDCR----MSTRPSLAMLQLHILSLFASGMLMSTWVWTRTTVNTWSRFFARK----------
>tr|B7Q4R2|B7Q4R2_IXOSC Putative uncharacterized protein (Fragment) OS=Ixodes scapularis GN=IscW_ISCW021763 PE=4 SV=1
------------------------------------------------CEPIINATCVSLPYGHTTVELVNDSTSQLEIQERLDLWQGLQIPRCWAVVQP
LLCAVYRPKCAD-GRVTLPSQEMCRLVRGFCKIVAL--GSEWPSFLRCQ-HDIFA--SGCKN-EMREIKFNTSG--------------------------
--------RCAAPLVATPRETSWYAEVEGCGVGCR----H--PLLTEDERLGMRTFVVVVSSIATLTSLFAVLTFMIGKESRQYPNVMVFYINLCLLLMC
VGWLAQFPGARDITCRRDGTLRSGEPS--SGENLSCVVIFCLVYYFLLAALCWFVMLTYAWDHRFQTRVPRESLDAKAAYFHLIAWCVPFVLTITVMALG
CVDGDPVSGICFVTSANPIVRSAFVLLPVTVAFFVGGYFLVREFYKLITLKVSNSDVLRVRTKIQSMILRIGLFVVTMVLLVSCTFVCHIYEFKSQPVWT
ESLRYVACRANPQSCD----PGSRPSLAMLQLHLVAFLGACVALSSWVLTAATAATWKRFWCRY----------
>tr|R7U0G2|R7U0G2_CAPTE Uncharacterized protein (Fragment) OS=Capitella teleta GN=CAPTEDRAFT_108217 PE=4 SV=1
-------------------------------------------QEVEHCDPIPPALCVSLPYSHTSAILAEDSSNVTDALQKLNLWTGLNVPKCWEVVQP
LLCSVYLPKCIENSVVYLPPKEFCDITRGPCKIVESY---GWPAFLNCN-QSHFI--SRCTSTVMKGLSFNTTG--------------------------
--------TCEAPLVATENRNSWYKDVDGCGVQCK----N--PLFTDQEHRQMHIFIAVCGSLCLASTLFTLLTFIIDKNSSRYPALILFFINGCFFIGS
IGWMAQFPGTRDIVCRSDGTMRVAEPQLGSGESASCSVVFFVVYFFMIAGCIWFVILSYCWHLLFSNMSPIKYIEAKRGTFHMFAWSLPLVLTIVCLALT
QIDGDSMTGICFVGGIKHGYRAGFVLAPISLVIVIGLVFLTSGLVKLIRMKVGSPGVIKASAKITDTIIRLGVFAVMALLFVIITFGVHLYIFTNEKRWL
KSFEYIFCEANSSPCV----MDARPSLIAMQMHVMAYFGTGVVMSLWVWNRNTLRTWKKFLR-K----------
>tr|V3ZM42|V3ZM42_LOTGI Uncharacterized protein (Fragment) OS=Lottia gigantea GN=LOTGIDRAFT_195892 PE=4 SV=1
-------------------------------------------NQNETCIPLTTNMCATLPIKFTSLTFAADSSSLDEVYEKLRLWSGLNAPQCWQVIQP
FLCSVYLPKCDNE--TELPSRELCERTREPCQIVKSFHDGSWPEFLRCD-QPQFV--SGCKIDTYEKLAFNTSA--------------------------
--------KCEHPLILTENKDSWFTDVPGCGIPCQ----N--LLFTKEEHDEVHIFIGVFGSICLVCTLFTVLTFLIDKNASRYPALILFYINACFFIGS
IGWLAQFGDARDIVCRSDGTARQGEPQIGSGETASCTIIFLMVYYTMMAGVMWFVMLAYSWHLTFKALTPKDSLSSKTAYFHLISWLLPLVLSIICLAMT
EIDGDSLSGICFVGYMKHGVRAGFVLTPIALVLVTGLFFLISGLVTLIKIRKAAPIFLKATSKLRETIYRLGTFSCLSLLFVLVTLSVHIYTFANEHLWR
ESFSYYKCKANSDVCH----IENQPSIVAMEIHIFAFFGAGIVMSSWSWNKATLNSWERFLR-M----------
>tr|A0A087QWH4|A0A087QWH4_APTFO Frizzled-9 (Fragment) OS=Aptenodytes forsteri GN=AS27_05248 PE=4 SV=1
-----------------------------------------------RCQPVDIPMCRGIGYNLTRMPNLLGHESQREAALKLHEFAPLVEYGCHVHLRF
FLCSLYAPMCTDQ-ASIPACRPMCEQARHKCVPIMEQFNFGWPESLDCGKLPTKNDNALCMEAPENASAAEP--HKGQGMLPVAPRPWPP--GAAEGRGP
GRGPNGLGACDNKFQ-------YVEKSLSCAPRCSPG-VD--VYWSREDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYS
MAFIIRSVAGANIACDRENGE-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEAHSSYFHMAAWGIPAMKTIVILTMR
-VAGDELTGLCYVGSMDV-ALTGFVLIPL-CYLVIGTSFILTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYFYERLNV-YWN
LRALERGCLHL-----GRLE-ASVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQSLC-NR----------
>tr|T1EGR1|T1EGR1_HELRO Uncharacterized protein OS=Helobdella robusta GN=HELRODRAFT_121253 PE=4 SV=1
------------------------------------------------CEKIEMPLC-DMRYNLTRMPNFFGHHTQREASDAIEEFLPMVKLGCSKLFRF
FLCTRYAPLCSEQSFIVPPCRSLCLEVKRSCAFTLAKINITWPPTLNCDSLPARSDEELCVQPPKVKVSAAAGEVGDYFDYGDGAD-----------FTP
VTSKKDKDGGSERRG-AK---EDVGSHYKCLQRCNR---N--ILHSARHKIFTKKFLKLWWIISMVASSFTFLSFVVNACKFKYPEKPIAYVSLCCLLMA
LTSLTAVLFDGFASCSSVDRM--H--V----PNRLSTGEFSLNYYTQLSSLLWFLILSTIWFLVATKKWGEEVLVSLSWFFHILAWGFPAGIVALAIVTR
-INGDELIPICRIGYSNTLSVLYYHAIPILACISVGVGLMIVGFVSVSRVIRGLKLFA--AENLEKVVCRLGVFSLLFTTFVILRLICLAVYYFQIDGWL
EKS-EKISKKC-----CEPGSF-----SLALLESFSMNSLSVTTIAWVWSWKTFDNWFQI--------------
>tr|A0A0Q3XY47|A0A0Q3XY47_ALLMI Uncharacterized protein OS=Alligator mississippiensis GN=Y1Q_003130 PE=4 SV=1
-------------------------------------------------------MCQNLGYNVTKMPNLVGHELQADAELQLTTFTPLIQYGCSSQLQF
FLCSVYVPMCTEK-IPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQ-NNHMCMEGPGDEEVPLH-SKMPLQPG-------------------
--EECHAM----QYI-------WVKRSLNCVLKCGY---DA-GLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYS
IAYIVRLTVGRRISCDFEEAA-----IQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMR
-VDADELTGLCYVGSQNLDALTGFVVAPL-TYLVIGTLFIAAGLVALFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNW----
----------------VFRYSGDDSNMAVEMLKIFMSLLTYFGNHDKCWGLDITREYSLTKDVL----------
>tr|A7SZJ6|A7SZJ6_NEMVE Predicted protein (Fragment) OS=Nematostella vectensis GN=v1g139208 PE=4 SV=1
---------------------------------------------DWKCEKISIDLCRSVGYNVTRMPNLIGHETQKEAESQLKQFLPLIQYGCARQLVF
FLCSAYAPMCTDK-VVITSCRPLCEYVRKSCLPVLTEFGIPWPNPLNCTRFLVRNNRNMCMPGPNFTESPEKPRPDFKPINDTTEKPPS----TGSEQCR
RFKNSKNY----FY-VQS--------TESCAVRCNE---D--GIFKTSDKETMDIWITIWSIFCFISTTITLTTFLIETGRFKYPERSIIWLALCYNFYS
LSYIIRLGAGRAISCDTDP--TT---IQDGLR-TGCAIVFLIQYFFCMAATIWWVVLALTWFLAAGMKWGCEAIGSYAKLFHIIAWILPCIKTIFILITR
-VDGDELTGLCFVGNQDLIALAAFVLGPQ-TYLIIGTLFLIAGFVALFRIRTTVQRGG-KTDKLERLIVRIGIFSVLSTVPATAVIACYFYEYANK-YWY
YG--D-----------G---AVAEPNFSIFMLKVFMSLFTGVITGMWIWSHKTMNTWRAFYYKV----------
>tr|E4YBW3|E4YBW3_OIKDI Uncharacterized protein OS=Oikopleura dioica GN=GSOID_T00020920001 PE=4 SV=1
-------------------------------------------TTAAICKDTVLPVCNFKAYNSTFLPNLLGQWSASEVAQTAAALFPLRAVGCSAHLDL
FLCSTLSPVCPGSLIPIPPCQNLCESVVSDCAGIMEEFGIQLPELFNCRQFPDSRTSAACIPPSNPTEPLPKSLIKWTKTEIKID------------PAI
SKGLQHQC--PKALM-ISDPSKTFAGIASCEKPCEP---M---VKETRDVTLVRMVMAVFCVVSAMISSFSIIIFLKDRKRFVYPERPTLYFALCYFIIS
ITVLATL-ISPESACAAADSG------ISALFSSQCIATFSIVFFFQVAATMWWLVLVLIWGLSLVLDLNLDVIESKGRILHLFAWTPALALTTIAVLQK
-ISADPFLGICALDG-DLSSFYFFSLLPLVTLTLIGLITFIAGLKKLLCVSSDFGS--TSAPKLEQFLFRISAFSCCFLIPKIAEEILKMSFSSLTETWY
HEN----CASL-VPCPLGVSPNEFIEPLIMLLRYVFFIIPSWAPMVWLANGKSLRAWGINSDTN----------
>tr|V5SP52|V5SP52_BRABE Frizzled 9/10 OS=Branchiostoma belcheri PE=2 SV=1
-------------------------------------------KDSGSCERITIPMCIGIGYNMTRMPNRLGHIDQTEAAIKVHEWSSLVQYDCSVNLRF
FLCSLYAPMCTEQDIPIPACRPMCEEVRDACSPIMAQFSFSWPENLNCDTLPEENDENLCMNAPNTSDSKDY--KQPTGDGVLAAP-----------PAA
HSTPSPRQKCPNKFL-------FVEKSGVCAPRCNAS-ID--VFFSRQDKEFVEIWMGIWSVVCVVSTSVVILTFMIDSRRFRYPERPIIFMAVCYFFYS
IGFILRLGLGRAISCDMDRGE-----IQEGLE-TGCTIVFLILYFFGMASSLWWVILTMTWFLAAGLKWGQEAIEAHSSYFHLAAWAVPAVKTIVVLTLR
-VDGDELTGLCYVGNQDR-ALTWFVLAPL-TYLILGTCFILAGFVNLFRIRKVMR-HGNSTERLEKLMSRIGIFSVFYTVPATCVVACYFYEQQNM-SWT
MAAQSIPCNNS-----VDLS-SSIPLVAVYCVKIAFLLLVGFGTSLWICSAKTMESWQNFC-NR----------
>tr|T1KDQ0|T1KDQ0_TETUR Uncharacterized protein OS=Tetranychus urticae PE=4 SV=1
-------------------------------------------PPVRTCEQIKFESC-KIGYNVTGFPNSAGHETQDEAGQTFQTFDPLIKFRCSSQLKF
FLCSVYFPMCTEKVQTIGPCRPFCETVRDRCLPILNDFGFAWPSYMNCSLFPAANDQTMCMVGPGEEEIESIANVRKIKPILDFKPPFAQDNYSSFPSPI
PDPCRGYKFHQQ-YF-RV---TTRSNTTQCVHDCLA---D--ILYLSSTKQFAGFWIAFWSTFCLASSVYAIFAFF-SPSRFQFPEKMIVYMGISYLFYS
VTHLFCILIGRSVGCYDEP-Q-----IQNGNENGYCLLVFALLYFSSLSSLLWWLMITISLFYVTTHQWSCKGLESFSSYFHSAAWGIPLLVTACILFKF
-IGADELTGICYVGNHDQIALLMFVIAPYVFFLGTGMLIFLLFVREYCKKTDQKIYPTPKLTEQLGWLTRLAMFQIIYFVISSYLLFVSFYEYLYRDAWY
SSL-----------------GSELPNVEVMSLKIFMSFLAGIMTGIWVWMSAPKIPFSTK--------------
>tr|G5EA13|G5EA13_HUMAN Frizzled homolog 6 (Drosophila), isoform CRA_b OS=Homo sapiens GN=FZD6 PE=1 SV=1
-------------------------------------------HSLFTCEPI-VPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIET
FLCKAFVPTCIEQ-HVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDEVPVTFDPHTE--------FLGPQKKTEQVQRDI-----GFWCPR
HLKTSGGQ----GYKFL--------GIDQCAPPCPN----M--YFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVS
LMYFIGFLLG-STACNKADEKLE---VVLGSQ-KACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMN
-VEGDNISGVCFVGLYDLDASRYFVLLPL-LCVFVGLSLLLAGIISLNHVRQVIQHDGN-QEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNR-TWE
IT--SDHCRQ-I-PCPYQSNQ-----------------------------------------------------
>tr|M7BLJ9|M7BLJ9_CHEMY Frizzled-3 OS=Chelonia mydas GN=UY3_13803 PE=4 SV=1
-------------------------------------------QQTYRSEDTVLTPGTELCLISVF-------KPCASCKKAMLPFHPMVNLECSRDFRP
FLCALYAPVCMEY-RVTLPCRRLCQRAYSECSKLMEMFGVSWPEDMECSRFPDCDEYPRLVDLN----------LAGEPTEEAPMAVQRD---YGFWCPR
ELKIDPDL----GYSFL--------RVQDCSPPCPN----M--YFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LIFFIGFLLE-RVACNASSPAQY---VTQGSH-KACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMN
-IEGDNISGVCFVGLYDVDALRYFVLAPL-LYVVVGVSLLLAGIISLNRVRIEIPLEKN-QDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAFR-VWE
TT--QERCRE-I-PCPYQGQSHGSRPTSV------VSASFGPPHTFGTGNVNGCPAVLDTD-------------
>tr|A0A0A0A5N2|A0A0A0A5N2_CHAVO Frizzled-3 (Fragment) OS=Charadrius vociferus GN=N301_10058 PE=4 SV=1
-------------------------------------------HSLFSCEPIILRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLECSRDFRP
FLCALYAPVCMEY-RVTLPCRRLCQRAYSECSKLMDMFGVSWPEDMECTRFPDCDEYPRLVDLN----------LAGEPTEEAPMAVQRD---YGFWCPQ
ELKIDPDL----GYSFL--------RVRDCSPPCPN----M--YFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LIFFIGFLLE-RVACNASSPAQY---VTQGSH-KACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMN
-IEGDNISGVCFVGLYDVDALRYFVLAPL-LYVVVGVSLLLAGIISLNRVRIEIPLEKN-QDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYR-VWE
TT--QERCRE-I-PCPYQVTQMSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFFHGR----------
>tr|H2SHS5|H2SHS5_TAKRU Uncharacterized protein (Fragment) OS=Takifugu rubripes GN=LOC101070067 PE=4 SV=1
-------------------------------------------HSEFSCEPIRLRMCQDLPYNTTFMPNLLHHYDQQTAALAMEPFHPMVNLECSPDLRM
FLCALYTPVCVVY-QVSMPCRSLCQRAKDECHKLMEIFGVSWPDDMECSNLKNCDEYPRPEDLLT---------GSDPTNQSSLTVQRD----YGFWCPR
ELKVDTDL----GYTFM--------GKKDCSAPCPS----M--FFSRQELTFIRYFIGVTSLICLSATLFTFLTFLIDVTRFRYPERPIIFYAACYVMVS
LVFFLGFLLE-RVACNAASPAHF---ITQGSH-KVCTLFFMVLYFFAMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVALLALN
-IEGDGISGVCFIGLYDIDALRWFVLAPL-LNVTVGVSLLFVGIVALNKVRMEIPLEKN-QTKLVKFMIRMGVFSALYVVPLLVVIGCYLYEHTYR-IWE
TT--EENCRH-I-PCPYKVKQISHPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWANFLQGR----------
>tr|M4ATD6|M4ATD6_XIPMA Uncharacterized protein OS=Xiphophorus maculatus PE=4 SV=1
-------------------------------------------HSEFSCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLVCSADLRM
FLCALYAPVCTEY-RMSMPCRSVCQRAKDECHKLMEIFGVAWPDDMECSRFPDCDEYPRAEDLLT---------GPEPTDQSSMTVQRD----YGFWCPR
ELKVDPDL----GYSFM--------GRKDCSAPCPS----M--FFSQQELTFMRYFIGVVSIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYVMVS
LVFFLGFLLE-RVACNAVSPAQF---ITQGSH-KPCTLFFMVLYFFTMAGSVWWVVLTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVSLLALN
-IEGDGISGVCFIGLYDIDALRWFVLAPL-FNVAVGISLLLVGIIALNRVRMEIPLEKN-QAKLVKFMIRMGVFSVLYLAPLFTVIGCYIYEHTYR-IWE
TT--EENCRR-I-PCPYMVKENKGIAQHSIR---------------------NCFPQF----------------
>tr|A0A0L7LLG7|A0A0L7LLG7_9NEOP Frizzled-7 OS=Operophtera brumata GN=OBRU01_03262 PE=4 SV=1
-------------------------------------------PHHGRCEPITIKFCQGIRYNQTIFPNILNHAKQEDAGPEVHQFTPLIKVNCSPDLKF
FLCSVYAPVCTIL-TAIPPCRHLCESARQNCDELMTNFGFHWPEQLDCSKFPVVTGNVICVGDNNATHESRKH-IETKLPKVDFKSNIERDKDYGFVCPV
QFKVPKSL----EYSLKV----EK-IEYDCGAPCNG----M--FFSQDEKNFSRLWIGVWATLCTISCLFTVLTFLIDTDRFRYPERPIIFLSVCYLMVA
AAYVMGWSAG-SISCQGPFPSTV--SITQGTK-EPCTILFMVVYFFSMASSIWWVVLTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPAMKTISILAMG
-VDG--------------------------------TIFLFAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGVFGVLYTVPALIVIACLFYEQANY-AWM
VT--RDMCST-I-PCPFNKE-ADRPKFEMFMIKYLMTMIVGITSSFWIWSGKTLVSWRQFFDRI----------
>tr|H9J8U3|H9J8U3_BOMMO Uncharacterized protein OS=Bombyx mori GN=LOC101740238 PE=4 SV=1
----------------------------------------------------------------------------------MLLFTTLIKLNCSPDLRF
FLCSVYAPVCTIL-SAIPPCRHLCEAAKQSCDVVIRKFDFPWPPELECSEFPEVSDNNICVGDNNTAHESRKR-TDTKFRKVDFKSNMERDRLHEFVCPV
QFKVPRHL----EYSFKV----NR-VEHDCGAPCNG----M--FFSKDEKNFSRLWIGIWAVLCALSCLFTVLTFLIDTDRFRYPERPIIFLSVCYLMVA
IAYIMGWSAG-NISCQGPFVSAV--SITQGTK-EPCTILFMIVYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPAVKTISILAMG
-VDGDVLSGVCYVGLWDAEALRGFVLAPL-VYLVFGTIFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGVFGVLYTVPALIVIACLFYEQVNF-KWM
IA--RDMCSI-I-PCPIIEE-IEGPKFEMFMIKYLMTMIVGITSSFWIWSGKTLISWSQFFDKV----------
>tr|A4UAH2|A4UAH2_9CNID Frizzled receptor 1 OS=Clytia hemisphaerica PE=2 SV=1
-------------------------------------------TSNKVCQHFKFELCKEMPYNTTLFPNILDNRNIEEAIKEMEVFSPMIKVACSELLQT
FLCSVYAPFCRED-GIMYPCRSICEKAREGCSELMNRLQFKWPQHLDCKNFPENTGKSLCLDETVLSLAYRKK-PKENPGGDTPGEYY------GKFNCP
PHQMKDEK----HYNFM--------GQEGCASKCEP----I--YFEKTEKEFARNWVLFWSIVCMLSTAFTLLTFVVDMPRFRYPERPIIFLSGCYFTVS
TAFLAGPLSG-AVSCHTQLKNRR--GLNQGTE-ASCTVVFMIIYFFLMAASIWWVILTLTWFLAAGLKWGHEAIEASSQYFHAAAWAIPAAKTIAILAMN
-VDGDALSGICFVGGNNVGALQGFVIVPL-ICLILGTFFLFSGFLALIRIRKVLKDDHLRTDKLTRLMIRIGIFSVLYSLPAIIVIACLFYEQSYR-TWN
ES--KSYCGDK---CKDF-IGKARPDFTVFIIKYLMLLMVGITSGFWIWSGKTIQSWKMFYYNK----------
>tr|T2MDS5|T2MDS5_HYDVU Frizzled-2 OS=Hydra vulgaris GN=FZD2 PE=2 SV=1
-------------------------------------------AANAKCIPFHFQICNKMPYNTTMFPNLLEHRNPEEASLEVAQFKPLVKVGCSDDLEF
FLCSVYAPVCLNH-GPLPPCKPLCERARSGCISIMQKFGFIWPENIRCERYPDSTPNALCIDNAETKKPEE---KVRVKNKTQSSYN--------DYRCK
TDQQKDAK----HYNFM--------GKPGCASECDP----V--YFTGKEKDFARNWVLFWSVVCLISTAFTLVTFFVDMSRFRYPERPIIFLSGCYFMIS
IAFLCGSLSD-AIACHKTD------KLNQGTE-AACTVDFMFIYFFLMSASIWWVILTLTWFLAAGLKWGHEAIEASAQYFHAAAWAIPAAKTIAILAMN
-VDGDLLSGICFVGGKNLSALRGFLLAPL-FYLVAGSVFLLAGFVALIRIRKVLKTDHLRTDKLTKLMVRIGIFSLLYSLPAIIVIACLFYEQSYR-VWD
KS--SAWCGGQ---CYHF-VGEDRPDFAVFMIKYLMLLMVGITSGFWIWSGKTIQSWKQFYYKK----------
>tr|V5SNB8|V5SNB8_BRABE Frizzled 5/8 OS=Branchiostoma belcheri PE=2 SV=1
-------------------------------------------IKDKICEEVTIPMCKGI-YNYTYMPNKFHHQNQEEAGLEVHQFWPLVEIQCSPALKL
FLCSMYAPICLED-HPLPVCKNVCQMAKDGCAPIMSQYQFAWPERFECDDLPEQGDDRLCMHFNASGDNTQKSTPALPTITAGSNGVPGGQGGCKCGCNN
PLVSIPPS----KSWYNRA-----GDQPNCGVPCYD------PYFDRSKKTFAKFWIALWAGLCCASTFMTVTTFLIDMTRFKYPERPIIFLALCYFFVS
LGYIIRLIAGHAVACEKDL-------RYGT--TALCTIVFLLIYFFSMASSIWWVILSFTWFLAAGMKWGQEAIASYAQYFHLAAWLIPSVKTIAVLAMS
-VDGDPVSGICYVGNQNLDNLRGFVLAPL-VYLIIGTSFLLAGFVSLIRIRKVIKQGGTKTDKLEKLMLRIGIFSVLYTVPATIVVACYFYEQQHR-AWE
RAL-ACPDCMP------------RPDYTVFMLKYFMCLVVGVTSGVWVWTGKTIDSWKQFHRKL----------
>tr|E3UKC9|E3UKC9_MNELE Frizzled OS=Mnemiopsis leidyi GN=FzdA PE=2 SV=1
-----------------------------------------------MSLDVKKELC-ESNITHVQFPNFLGMETQQEAIDGLKGYELLLTQHCSSSLAF
FLCHTYLPICNPE-VIIKPCRAECEMSRFNCSSLMVHYSYPWPEILSCDKFNWFTESKVCAGNPTYTKDNFF--KMFPEVVNGTYQHYDPDTELKTPDSD
DYGFNRSNCPTIGLV-NA---DKKFNDFNCGLKCDS---N--YFGPRGNTNILKHWTLVWGGLCCLATLFTVMTFIFDQQRFRYPERAIIFSAVCYFFIS
VGFVLGYFFDDI-VCENNGG-----NVMRQGSSYLCFFQSFLIYYFMLASFLWWVILNLTWFLAAGLKWGHEAIALKAKFFHGVAWILPGILFLVICIKE
-IDGDRLANICFVGNFKTDSLQFYVIAPLAIFYLCGMTFLGLGMFSMCNVRHELHNTG--TDKLETLMIRIGMFSVLYSIPATILIACFLYERFQRPKWE
TAYVTKKCHSS----------ADANLLTFNLIKYLMMLVTGLSTGFWVLSFKTASNWARLLKCV----------
>tr|F6QEW9|F6QEW9_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=FZD10 PE=4 SV=1
-----------------------------------------------------------IGYNLTRMPNLMGHEDQREAAIQLHEFAPLVEYGCHGHLRF
FLCSLYAPMCTEQ-APIPACRVMCEQARLRCSPIMEQFNFRWPDSLDCGQLPNKNDNYLCMEAPNNGSEEP---ARGPGPFAPAARPPRP--HGPPDPRP
GDGGPGRPGCRGKFH-------LVEKSSACAPLCDPG-VD--VYWGRDDKRFAAVWLAVWSVLCFSSSAFTVLTFLVDPARFRYPERPIVFLSMCYCVYS
AGYLIRLFAGASIACDRDGGR-----IQEGLE-TGCTVVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIAILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLVPL-CYLVVGTSFVLSGFVALFHIRRVMK-TGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
ILAAQQKCRVD-----TGMS-GSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVC-SR----------
>tr|H3CS14|H3CS14_TETNG Uncharacterized protein OS=Tetraodon nigroviridis GN=FZD6 PE=4 SV=1
-------------------------------------------HSLFTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATNMKPFMPLIKLRCSPGVHH
FLCQAFFPACF-ENVGSRPCREECKTVLSDCKDNIQVFGISWPPELQCDNRLDPC---FLTRDDTTPE------TPPATSPTKRDLG--------FWCPL
QLKTKPGL----GS--------SFLGAQDCAPPCSN------MFFKPHDVEFAKSFIGVCSIVCLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LMYFIGFLLGDSVACARASHPA----VVLGSQ-KACTLLFMLLYFFSVAGLVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGLLTVMLLALN
-VEGDNISGVCFVGLYDLDALRYFVLAPL-VGVAVGLFLILAGIVSLNNVRQVIQHDE--QEKLKKFMIRIGAFSCLYLVPLVTLLACYTYEQSHR-AWE
RT--RDRCQEY--PCPSEAE-LERPDLFLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNRT----------
>tr|A0A0B5CM78|A0A0B5CM78_OSCCA Frizzled B OS=Oscarella carmela PE=2 SV=1
-------------------------------------------VRRANCYEMNVDTCAGIGYNTTLLPNRFGHRTLPEAALEISTYVPLIQFKCSPELRF
MACATFLPICTTDKRTLPPCRQMCQRVQTGCEPVVKRWGVAWPAALSCDELPDEMDTPPCFDNATQYAIDIPGGPDSGFNTTYPPLLPAEENNSQLLAKR
DSCYRYMS--G-EGFLCI----NCNYDEQAKPGESA---G--YYFKQEDIAFANYWVGIWAVLCFLSTLFTCLTFLIDRDRFHYPERPIIYLAVCYCVFS
LGFIARLFAGDRIACDQT--------IKADAN-AGCTAIFMVLYFSMMAASVWWVVLTVTWFLAAGMKWSNEAIESLALYYHLVAWIVPLIMTIVALILQ
-IDADELTRVCFVGAQDVNAMAGFVVAPL-LFLVVGTIFIIAGFAALFRIREVIKSDR-RSGKLEKLMIRIGVFSVLYTVPATIVIGCYFYEYFAR-LWS
VHT-APQWNQLDSSNKTFCT---QALPAVFYIKFLMSLIVGVTSGVWIWSSKTLATWNSFISK-----------
>tr|A0A0B5CS91|A0A0B5CS91_OSCLO Frizzled B OS=Oscarella lobularis PE=2 SV=1
-------------------------------------------VREARCFQSDVDTCAGIGYNRTLLPNRFGHRTLQEAGLEISTYIPLIQYGCSPELRF
MVCATFLPICIETKRTLPPCRQMCERVRKGCERTVRNFGVLWPTALSCNELPDENENVVCFDNATQYAVDLGLRPNINITTPGPEVTAFI--RNDSGSAK
SNCWRYYE--NSDPFYCV----DCKYNKSAT-DVPS---G--YYFKETDIEFAKYWLGVWAILCFLSTLFTCLTFAIDRDRFHYPERPIIYLACCYCVFS
IGFIARLASGENIACDNE--------IKGDAN-PGCTATFMVLYFSMMAASIWWVVLTFTWFLAAGMKWSNEAIENVALYYHLVAWILPLIMTIIALILQ
-VDGDELTRICFVGAQDVNAMAGFVIAPL-LFLVIGTTFIIAGFAALFRIREVIKSDP-RSDKLEKLMIRIGVFSVLYTVPATIVIGCYFYEYFAR-QWH
PYT-YPDWFQYEIKDLKDCL---RAQPAVFYIKILMSLIVGVTSGMWIWSGKTLSTWRSFIVTT----------
>tr|E4XC75|E4XC75_OIKDI Uncharacterized protein OS=Oikopleura dioica GN=GSOID_T00007729001 PE=4 SV=1
-------------------------------------------SSAKICEKVVVDFCDIFIKSGQTATTAAS-NDQTLIAKQLEQYASLEKVDCDNMVKM
FLCFYYLPYCH-DMKSVPPCRQWCQNFKNSCFRRFNQYNPKWPSELQCDILPEFSEGFQCIKNPVQKDSSDSYRELSSLSPAAYENDHCVEELKCPPEFQ
VRSTDGPS----KY--------NFLGLGNCSAPCKD------HFWSKKDIDLAKKWILAWSVLCLISTLFTVLTYVIDKDRFKYPERPIVFLAACYLIVS
IVYITGYFNGNDVACTSNNPYEDPNDVVQGTK-QSCTILFMILYFSTMASCIWWLVLCVNWFLAAVLKWSGEAIEAQAQYFHLVAWAVPAIATMSVLALG
-IEGDPLSGICYTGQYDTTSLQIFILWPQ-IFLCIGFVFLIIGFLSMYRIRAVVKNEH-KHEGLEKLMLKIGVFSSIYLIPGSILLGCYFYEYMYN-IWN
KS--NKYCNYEFTC--S---CHREPNFTFFMLRYFMMLIVGLSCGFWIWGEKTMESWKQFLSCA----------
>tr|A0A0N5AKD9|A0A0N5AKD9_9BILA Uncharacterized protein OS=Syphacia muris PE=4 SV=1
-------------------------------------------QNSTNCVKITMEYCRDIPYKEAIFPNLLNHRTQAEAAEEIQQYSLLVQIQCSPDFRF
FLCSLYVPLCN-SGRPIPPCRYLCESSKAGCEKIMKRLGYRWPDVFDCDKFPVIPE--LCIGENRSNTDARNVKVVDHDVDECP---------------L
NMQVRTTA----EYSLSI----ANETLKQCSLPCDADDTE--IFFDSRIRRFIRFWTGAWAVICCACTLFTVLTFSIDMGRFPYPVRPIFYLALCYLFIS
FVFMIGLVAENRISCAAVSYK-----VSQGME-SSCVLLGVIHYYFSTASSIWWVILCVAWFLAANLKWAQESIESLASYFHLLGWGVPALLCIMALISH
-IDGDLFTGICSVGNLKPTTLFNMVFIPL-ICIAFGLLFLGFGIISMVRIRKYIKVKHHNIRKLEKLMLRICAFAFMYTLPTMVSAVCIGYEAFMM-NWL
TR--RCSNS-VD-PLRRSQN-VQKPEPMIYLFKYLFQLVIGITCAVWVCSSKTLESFSKAYARV----------
>tr|A0A0N4VM29|A0A0N4VM29_ENTVE Uncharacterized protein OS=Enterobius vermicularis PE=4 SV=1
-------------------------------------------SNSTNCVKIDIEDCRSIPYKEAIFPNLLNHKNQAEAAMEIQHYSSLIQIQCSPDLKF
FFCSLYVPLCN-SGRPIPPCRYLCESSRAGCEKIMRKFGHSWPDVFDCERFPVVGD--LCIGENRSSSETKTMKVVDRDFDECP---------------N
NMQVRTTE----EYTLSI----ANETLKQCSLPCDPDDSQ--MFFDARIRRIIRFWTGAWAVICCASALFTVLTFSIDMARFPYPVRPIFYLAICYLFIS
FVFMIGLVAENKISCAAVSYK-----VSQGME-SSCVLLGVLHYYFSTASNIWWVVLCVAWFLAANLKWAQESIESLASYFHLIAWGIPALFCIMVLISH
-IDGDPFTGICSVGNLKPTTLFNLVFLPL-VCIAFGLLFLGFGIVSMVRIRKYIKIKHHNIRKLEKLMLRICAFAFMYTFPTIVSAACIGYEAFMM-SWL
TK--KCGNT--D-SSRKAQN-IQKPEPMVYLFKYLFQLVVGITCAVWVCSSKTLESFSKAYARI----------
>tr|F1KRM3|F1KRM3_ASCSU Frizzled-1 OS=Ascaris suum PE=2 SV=1
-------------------------------------------AANEKCVPITMQMCKDIPYNMTLYPNILGHTKEEDASLEVHQFLPLVKVKCSEDLKF
FLCTIYAPVCT-VGRPIPPCRHLCLSAKLGCENLMNKFGFKWPPPLACELFPTD-G--MCVGENRTDTSTEAPHAHPRATMFTQME-----------CPH
TMQVLSKS----KYSLRV----ANTTLEQCSLPCSADLVP--MFFDSRIRRYLRFWTGAWAVACCASSLFTVLTFLIDMGRFAYPVRPIFYLAICYLFIS
FVYMLGLVAEDKISCAAVSAS-----VSQGMH-FPCTVVAVIHYYFSVASSVWWVVLCVAWFLAANLKWAQESIEGLSSYFHMLAWGIPAFLTIAVLVTN
-IDGDLFTGICSVGNLKPSALFNFVFIPI-TCIALGLLLLGCGIVSMLRIRRYIKFKHQNIRKLEKLMLRICAFAFMYTLPTMVSAACLAYEAFMM-SWM
AN--AMRCA-RF-SLPRQEN-VRPPDLLIYFFKYLMQLVVGITCAVWVCSSKTLNSYSQAYARI----------
>tr|A0A0N4U763|A0A0N4U763_DRAME Uncharacterized protein OS=Dracunculus medinensis PE=4 SV=1
-------------------------------------------IVNEKCVPITMQMCKDIPYNMTLYPNILGHTKEEDASLEIHQFLPLVKVKCSEDLKF
FLCTIYAPVCT-VGRPIPPCRHLCLSAKMGCENLMNKFGFKWPPLLSCDRFPSD-G--MCVGENRTDSSTEAPHLHSHERLFQIE------------CPH
SMQVLSKS----KYTLKV----WNTTLEQCSLSCSADLVP--MFFDSRIRRYLRFWTGAWAVACAASSLFTILTFSIDMRRFPYPVLPIFYLSICYLFVS
FVYMVGLVAEDKISCSAISAS-----VSQGID-FPCTIIAIIHYYFS---SIWWVILCLAWFLAANLKWAQESIEGLSSYFHVLAWGIPALLSIVVLITN
-VDGDLFTGICSVGNLRPSALFNLIFIPM-YFLALGLLLLGCGIISMLRIRRYIKFKHQNIRKLEKLMLRISAFAFMYTLPTVVNTACIAYEAFMM-SWL
TN--AIRCA-RF-SQPRNEN-IRPPDLLIYFFKYLMQLVVGITCAVWVCSSKTLNSYSQAYARL----------
>tr|A0A0K0E9P8|A0A0K0E9P8_STRER Uncharacterized protein OS=Strongyloides stercoralis PE=4 SV=1
-------------------------------------------SNNNKCVPIRIKMCSDIAYNMTMFPNLLQHQKQEEAEIEINNFLPLVQVKCSEDLKF
FLCTVYAPFCN-VPKPLPPCRHLCMSARNGCENLMNKFGFNWPTPLDCDNFPID-G--LCVGENRTSSSNLNNSKYGQKKIVEPNLLDF----IDLECPK
AMKSRSMN----TYQLYI----SNKTLDQCSLPCKADIFP--MFFDEKIRGFIRLWTSTWATISLCASTFTALTFLIDLHRFRYPIRPILYLSICFVGIS
SVYIIGMTSEGNHACSSISAK-----TTQGLD-FWCTVMAVIYYYCQISGGFWWLILCYVWYLTSNLQWGTEAIEAISSYFHLMAWGLPFLLTILLLIFP
-VDGDMFTGICSMGNLNTNVLFYFVFIPL-ITLIIGLMYLVLGIISLLRIRRYLKCKQTTSSKVQLLMIRISTFAVLYTIPTIIFLASIFYQSKYF-RWL
TE--SLRCN-HF-STSRHDLFVSAPDPLLFYAKYSSQLLIGVICAIWVSSGKTIKSYANAYSRL----------
>tr|A0A0N4T1Y5|A0A0N4T1Y5_BRUPA Uncharacterized protein OS=Brugia pahangi PE=4 SV=1
-------------------------------------------AANDKCVPITMQMCRDIPYNMTLFPNILGHTKEEDASLEIHQFLPLVKVKCSEDLKF
FLCTIYAPVCT-VERPIPPCRHLCLSAKNGCENLMNKFGFKWPPLLACERFPVD-G--MCVGENKPDTSTEAPHSRSGTSITQIE------------CPH
TMQVISKS----RYSLKI----LNTTLEQCSLPCSADLVP--MFFDTRIRRYLRFWTGAWAVACCASSLFTVLTFSIDMARFPYPVRPIHYLALCYLFIS
LVYMVGLVAEDKISCSAISAS-----VSQGID-FSCTVIAVTHYYFSVASGVWWVILCLAWFLAANLKWAQESIESLASYFHVLAWGIPAFLAIIILVTN
-IDGDLFTGICSVGNLRPSALFNFVFVPM-VCIALGLLLLGCGIISMLRIRRYIKFKHQNIRKLEKLMLRISAFAFMYTLPTMVSAACIVYEAFMM-SWL
AN--AIRCT-RF-AQPRQTD-VRPPDLLIYFFKYLMELVVGITCAVWVCSSKTLSSYSQAYARI----------
>tr|A0A077SQW2|A0A077SQW2_9METZ Frizzled A SciFzdA OS=Sycon ciliatum GN=FzdA PE=2 SV=1
-------------------------------------------EYFDRCMPNEVSYC-TLWYNFTVS-----HPEQQIVSGFMNHFEPIASRVCHRHLFR
FLCFSLAPMCLPGEKVVLPCRRLCEAVHSDCSPKMDLLGVQWPGFLKCSDLPEKNCE-----FYGDSDAVTGYDVIPFRRIGGSDEKLSGRSAPEPDKSV
CPKSMSTDNS-STFF-------NVANISHCGIPCKG---S--IAQELSSPIALTVIRLLLSLTTFGATMVA-VCFYFHRRLFELLDKPVVLLTMSMAVLS
MVLFLTRMMDGGVFCSRHHGM------VHQPSSGTCVGVFLSTHFMCTVSALWGLVFACLVFLKHAMLYTDANQSYCFTYLTAVAVFMAMVFTSAVAIVG
-IEGSSITQLCQVQRSFS---VSQFILPLGIYLLTLIITILAAIIRYNQQRQPKGGLS-SSNEEESWMVSVVFISALLTFGGVLIGAVGVNQAPNTVHWE
KTI--LACQQQSLACT----QGSHPSMALIVLEELARLLPGFLCAAWLYRQKRVKNSRRPLETA----------
>tr|S4S0H3|S4S0H3_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVL-EAIPPCRSLCERRQ-GCETLMNKFGFQWPERLRCENFPVQGSENICVGQNHTDEKGGHPTPPDPHPIPHGDSFTLPPSYQLTCPHV
LRVPSYLN-----Y--------QFLGKKECGSPCEPSSNGL-MYFDADELWFARMWVGVWSILCCASTLFTVLTYLVDMERFRYPERPIIFLSGCYAVVS
IAYIVGFFFE-KIVC-N-KFFE----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-VDGDVLTGVCFVGLNSIDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
KSW-AHTCKSF-VQCPQGHYPNMKPDFTVFMIKYLMTLIVGITSGFWIWSGKTLQSWRNFYSRL----------
>tr|S4S1L6|S4S1L6_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIPYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVL-KAIPPCRSLCDRRQ-GCEALMNKFGFQWPERLRCENFPVQGSDEICVGQNHTDKAGPTALPPTPPGGGGGVIGGIGGTHPFMCPRV
LKVPPYLN-----A--------QLFRERNCAAPCEPKPNGL-MYFSEEELRFSRLWVGIWSVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYFMVA
VAYVAGFLLD-KVVC-NEQFSE----VTQGTK-EGCTILFMLIYFFSMASSIWWVVLALTWFLAAGMKWGHEAIEANSQYFHLAAWAIPAVKTITILAMG
-VDGDMLSGVCFVGISSVAALRGFVLAPL-VYLFLGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
KTW-SQSCKGF-IPCPLNHYPNMKPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTKL----------
>tr|V5SQJ2|V5SQJ2_BRABE Frizzled 1/2/7 OS=Branchiostoma belcheri PE=2 SV=1
-------------------------------------------GHHGRCEAITIPLCTDIQYNETIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPDLKF
FLCAMYAPVCTVLEEAIPPCRSLCNSARTGCEALMNKFGFQWPESLECSKFPVQGTGKICVGENRTEQIPTAVPTANNGNSSAVTENPIRK-DYGFYCPR
ELKVSPAL----GYSFLG--------AKDCGAPCDS------MYFRDDEVEFAQVWIGIWSVLCACSCLFTVLTYLIDPGRFRYPERPIIFLSACYLMVS
VAYIVGY--K-KVSCMEGVWMQE---VTQGTK-EGCTILFMMLYFFSMASSLWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTIAILAMG
-VDGDVLSGVCFVGISDIDALRGFVLAPL-LYLVIGTLFLLAGFVSLFRIRTIIKQDG-KTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQAFR-EWE
RS--VDNCEK-FIPCPPGARPSANPDFTVFMIKYLMALIVGITSGIWIWTGKTVQAWKRFYGQI----------
>tr|H2YB70|H2YB70_CIOSA Uncharacterized protein OS=Ciona savignyi GN=Csa.4359 PE=4 SV=1
-------------------------------------------NVHPKCRPVMLPMCVKWIYNSTTFPNFNNDANEQEVEISMSAIHPLISTSCSRFLEL
FLCSVFSPACTGNV--VPPCRSLCLKVKEDCEAVTQMFGIAWPPRLDCDNFPLQD---DMTGNGNDAGDAILVNSIIWSEALLSDVCIPLSPADYEVRCP
AHMRAPPDQPGYTF----------LGLDECAAPCP----N--MYLDPVELSIVRYIIIVLASLCVVVTSFVLFTFAIDTNRFRYPERPIVFYATSYLVIS
CIF-IVGILGPV-ACNEQVTN--EENVTEGFHRRFCTVVFMVLYFFTVNGTIWWLILTVTWLLAAGLKWGSEAIEKYSHYYHGLAWGIPAIQTMIVITSG
-IEGDNIAGVCFVGLYDSEGLRYLLLLPMSLYLIVGIIVLLTGFICLNRVRKSLDD--ANQKNLAKFMLRIGVFSILYILPQVVLIAIYAIEDSNRKYWE
SAWF-VNCGNYGIPCPAEAEGNPHPGIIIFCLKYVMTLVVALPPLFWVASKKTVTSWQNFVTKP----------
>tr|E0V9Z7|E0V9Z7_PEDHC Class D atypical G-protein coupled receptor GPRfz5, putative OS=Pediculus humanus subsp. corporis GN=Phum_PHUM024690 PE=4 SV=1
-------------------------------------------------------MCQNLGYNLTTLPNFMDHKDQSQAERALGTFMPLVHYNCSKHLRQ
FLCAVLTPMCSEQ--AIPPCRGFCERIQGDCQPVIDQFEFPWPSLLNCSRFPV--YG-YCISGNQSTENS----KALSVPTWLDNNVR-------RDSVM
MQCPPNFV--QT----------MEFSSVTCSPNCGK---D--AYYRKEDKLFAEKWMVGWAWLCFLSTSFTLLTFWVEPSRFRYPERPVIFLALCYCLIG
VTYILRGALGPTFSCVHV--E-----AVDGMQ-MPCTLAFLSLYYFALASSIWWVILALSWFLSAANKWSSEALHGLASYFHVAAWTGPAVLGIVALALR
-IAGDELTGLCQVSDS---DVLAFLVVPQ-VLLSAGCVLATIAAAALIRVRRTMQSAG-CTGKLERLMTRLGVFAILYVLPAIGYLACLIYEAWHR-RWR
SLA-LLAALDCPSCEPG--PSYRTAGVEMALLRLFLSLVVGVTSGMWVWSGKTCRAWSRLFVSP----------
>tr|A0A067QSB2|A0A067QSB2_ZOONE Uncharacterized protein (Fragment) OS=Zootermopsis nevadensis GN=L798_01927 PE=4 SV=1
---------------------------------------------------------------------------------QLLAFIPLVHYNCSRYLRF
FLCSVFAPLCTEH--PIPACRGLCEEVQADCQPVMETFNFPWPSMLNCSRFPV--LKGLCMQFPNASEEPIHANSESGGVTWAVNPA---------PVHT
QQCPPNFA--RA----------REPRAITCSPRCGR---D--AYYRSEDKKFAETWMIGWAWLCFLSTLFTLLTFWVEPARFRYPERPVIFLAVCYNLLA
LAYILRGLLGPAFSCVSP--SD----AVDGLE-GPCTLTFLALYYFGMASSVWWVVLATSWFLSAAKRWSCEALHRLSTYFHIAAWAGPAVLGVVALALH
-VTGDELTGLCQVSEG---AAVPFLVVPH-VLLLVGCVLAALGGAALIQVRQAMKSAG-STSKLERLITRLGVFAALYVLPVMGSLACVLYEAWHR-RWR
SLA-LLAALDCPSCTPG--PSYQAAGVEVALLRLFLSLVVGVTSGMWVWSGKTCRAWSKLFTAP----------
>tr|F4WR01|F4WR01_ACREC Frizzled-10-B (Fragment) OS=Acromyrmex echinatior GN=G5I_08249 PE=4 SV=1
-------------------------------------------------------------------------------------FMPLVHYNCSKHLRL
FLCAVFAPVCSEH---IPACKSLCLSVRRDCEPALTSLALPWPHLLDCNRFLDR-GT-LCVQPPDETLDNTSSPTLPTVQQQWPVMYER----PPQISIR
LQQQQQHYQCPPHFV-QI----SEMEMISCAPRCGT---D--AYYRAEDKKFAERWMTGWAWLCFLSTLFTLLTFWVEPSRFRYPERPIVFLALCYNLLS
MAYIVRAVVGANLSCVSQID------VRDALKSIPCTIWWLVRYYLGLASNMWWAVLCGCWLLSARNEWSSEALYDIAPYLHTAAWILPIFFTGGSLLSH
-VVADELTGLCQISDESA---LWLEVLPHAMLLLLGCVFGSVAGSALVRVRRAVRC-A--AMKLERLMTRLGIFALLYALPALGGLVCVLQEASVRPRWR
KLALLAALDCRAQNCTPG-PVYRAAGLEVALLRLFLSLVVGVTSGMWVWSGKTCRAWSRLLVAP----------
>tr|A0A091I3M4|A0A091I3M4_CALAN Frizzled-2 (Fragment) OS=Calypte anna GN=N300_11234 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPVHADHGFCQPISIPLCTDI--AYNQTIMPNLLGHTNQEDLEVHQFYPL
VKVQCSLE-----L--------KF----------------F-LCSMYAPIRFARIWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVS
VAYIAGFVLE-RVVC-NERFQE----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-IDGDLLSGVCFVGLNNIDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHGG-KTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR-HWE
RSW-SQNCKSL-IPCPLHFTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|G3WWL4|G3WWL4_SARHA Uncharacterized protein (Fragment) OS=Sarcophilus harrisii GN=FZD10 PE=4 SV=1
-------------------------------------------GE-GKCQPIEIPMCKDIGYNMTPMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRF
FLCSLYAPMCTEQ-TPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDNYLCMEAPNNGSDEP---ARGSSMFPPLFRPQRP--PSPPEQQH
PKDGLGRSGCSNKFH-------HVEKSSSCAPLCTPG-VD--VYWSRADKQFAVVWLAIWAVLCFFSSAFTVLTFFIDPPRFRYPERPIIFLSMCYCVYS
VGYLIRLFAGASIACDRDSGQ-----IQEGLE-TGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLVPL-CYLIIGTSFILSGFVALFHIRRVMKTTGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
VLAAQHKCRVN-----TKMS-SSIPAVEIFMVKMFMLLVVGITSGVWIWTSKTLQSWQNVC-SR----------
>tr|W5NNP7|W5NNP7_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
-------------------------------------------AE-GRCQHIVIPLCKDIGYNMTRMPNLMGHEDQGEAAIKLHEFAPLIEFGCHSHLKF
FLCSLYAPMCTEQ-TPIPACRVMCEQARQKCSPIMEQFSFKWPDSLDCSKLPNKNDNYLCMEAPNNGSDES---PKGSSTQPPEFRLQRP---NSGQEFQ
LKDTSDREACGNKFH-------YVQKSESCAPKCYPK-VD--VYWSQGDKQFSLIWIAIWSILCFFSSSFTVLTFLIDPQRFKYPERPIIFLSMSYCVYS
VGYLIRLFAGANIACDRDSGV-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGVCYVGSMDI-ALTGFVLIPL-CYLIIGTSFLLSGFVALFHIRKIMK-TEENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
VLASAQKCFES-----SPMK-NSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVF-SR----------
>tr|Q9W6E3|Q9W6E3_DANRE Frizzled homolog 10 OS=Danio rerio GN=fzd10 PE=2 SV=1
-------------------------------------------GE-GRCQEIAIPLCKDIGYNLTVMPNLMGHEDQNEAAIKLHEFAPLIEFGCHSHLKF
FLCSLYAPMCTEQ-TPIPACRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPNKNDNYLCMEAPNNGTDEP---PKGSHTQSPDSRPPRP---GNSQELP
IKERVGKTTCSNKFH-------YVQKSESCAPKCYSN-VD--VYWSQGDKRFSMVWIAIWSILCFISSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYS
VGFLVRLFVGVNVACDRDTGV-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAIKTIMILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLIPL-CYLIIGTSFLLSGFVALFHIRKVMK-TEENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
ILAGEQKCADD-----SGMK-SSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVF-SR----------
>tr|Q4SXY4|Q4SXY4_TETNG Chromosome undetermined SCAF12285, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis GN=FZD10 PE=4 SV=1
-------------------------------------------GE-RRCQQINIPLCKDIGYNMTRMPNLMGHDDQKEAAIKLQEFATLIQFGCHSRLKF
FLCSLYAPMCTEQ-NPIPACRVMCEQVKLKCSPILEQFNFPWPESLDCSRLPTKNVNNLCMEAPNNGSEEP---PKVSQTQPPDFRPQQP---LGGQDLQ
LKDSGGKQKCPNKFH-------FVEKSESCAPKCYPS-VD--VYWSQGDKRFSLVWIAIWSILCFVSSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYS
VGYLIRLFVGAGIACDRDNGV-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLIPL-CYLVIGTSFLLSGFVALFHIRKIMK-TEENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWR
VRAEGEKCMDG-----ESLK-SSIPAVEIFMVKVFMLLVVGITSGMWIWTSKTLQSWQNVF-SR----------
>tr|A0A0P7TRS3|A0A0P7TRS3_9TELE Frizzled-10-like OS=Scleropages formosus GN=Z043_117823 PE=4 SV=1
-------------------------------------------GD-GRCQHIEIPLCRDIGYNMTKMPNLMGHADQGEAAIKLHEFAPLIEYGCHSHLKF
FLCSLYAPMCTEQ-TPIPACKVMCEQVRLKCSPVMEQFSFRWPDSLDCSRLPSKNDNNLCMEAPSNSSEEP---AKGPHTQPPDFRLHRS---SGGQELQ
MKDSGGRKTCANKFH-------YVQKSESCAPRCYPR-VD--VYWSQGDKQFSLFWMSVWSILCFVSSSFTVLTFLVDPQRFKYPERPIIFLSMSYCVYS
VGYLVRLFAGANIACDQDNGV-----IQEGLE-TGCTIVFLILYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLIPL-CYLVVGTSFLLSGFVALFHIRRVMK-TEENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWQ
IKAREQTCVEG-----EPMK-SSIPAVEIFMVKIFMLLVVGITGGMWIWTSKTLQSWQNVF-SR----------
>tr|R7UK25|R7UK25_CAPTE Uncharacterized protein OS=Capitella teleta GN=CAPTEDRAFT_166935 PE=4 SV=1
-------------------------------------------VKVRDCEPITVDKCHNLPYNVTGMPNLVGHANQADAELQFNTFTPLIQYECSKALRF
FLCSVYFPMCTEK-KPIGPCRPLCEHVQLKCRPVLRQFGFPWPNALNCSKFPIRNDTHMCMVGPEISGDGDGTESSYGASSRIAQLSPRLESTVVSSVCQ
HLNNADLY----IY-INR--------TESCALSCSS---H--DLFTESDKEFADIWMFIWALLCFVSTLFTALTFAIDAGRFRYPERCIVFLSLCYNMCS
IAYIVRLAVGRAISCGLDA--AT---IQEGLD-SDCSIVFLLQYYFGTASCTWWVLLTVTWFLAAGLKWSSEAIQRHATTFHVIAWALPAVKTIVILVIR
-IDADELTGMCYVGNQRLDTLLGFVIVPL-VYLFIGVIFIILGFIAMFRVRRQVRREG-KTEKLEVLMVRIGVFSVLYTVPAMCVIGCYLYEYLNR-LWH
SV--A---------------GQHRPNMEVFMLRIFMALAVGMTSGMWVWSAKTLSSWRNLFARM----------
>tr|Q4T6Q4|Q4T6Q4_TETNG Chromosome undetermined SCAF8669, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis GN=GSTENG00006192001 PE=4 
-------------------------------------------RP-AKCEPIVIPMCEGIGYNLTRMPNFMDHDDQAEAAIKLNEFAPLVAYGCDVHLRF
FLCSLYAPMCTDE-NLHPCLQT-VRAGEGEVRPHHE------AVQLHLARFARLNDNALCIEAPENETKAEG--KKGEGMLPVPPRSR------QPGAGE
SHPPSTTGSCENKFQ-------FVEKSQSCAPRCSAA-VD--VYWSKQDKDFAFIWMTVWSILCFISTAFTVLTFFLEPHRFQYPERPIIFLSMCYNVYS
VAFIIRSVAGANIACDRENGE-----IQEGLE-TGCTIVFLILYYFGMASSIWWP----------GRSGGTRPLKPTVTTSTWAAWGIPALKTIVILTMR
-VAGDELTGLCYVGSMDA-ALTGFVLTPL-CYLIIGTSFILTGFVALFHIRKVMK-TETNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNM-YWK
LRGEQMKCGMF-----GLLQ-ASVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLC-SR----------
>tr|H2M7Q8|H2M7Q8_ORYLA Uncharacterized protein OS=Oryzias latipes GN=fzd9 PE=4 SV=1
-------------------------------------------RP-AKCEPIVIPMCVGIGYNLTRMPNFMDHDDQAEAAIKLQEFAPLVDYGCDVHLRF
FLCSLYAPMCTDK-TSIPACRPMCEQARDKCAPIMKKFSYTWPDSLDCSKLPTRNDNALCMEAPENETRTEGKKDKKKGEGMLPVPPRP----RQPDTPS
SRLPGSGNSCENKFQ-------FVEKSQSCAPRCSPA-VD--VYWSRQDKDFAFIWMTVWSILCFVSTAFTVLTFLLEPHRFQYPERPIIFLSMCYMVYS
LAFIIRSVAGANIACDREHGE-----IQEGLE-TGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIEAHSNYFHMAAWGIPALKTIVILTMR
-VAGDELTGLCYVGSMDS-ALTGFVLIPL-CYLIIGTSFILTGFVALFHIRKVMK-TETNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNM-YWK
LRGLQEECDSF-----SHLE-TSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLC-SR----------
>tr|E2RAF3|E2RAF3_CANLF Uncharacterized protein OS=Canis lupus familiaris GN=FZD9 PE=4 SV=2
-------------------------------------------RGPAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRF
FLCSLYAPMCTDQ-TPIPACRPMCEQARLRCAPIMEQFNFGWPESLDCARLPTRNDHALCMEAPENATAGPA--EPHKGLGMLPVAPRPAR-PPGDPASG
PGGGGGGGTCENKFQ-------YVEKSRSCAPRCGPG-VE--VFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYS
LAFLIRAVAGASVACDQEAGA-----IQEGLE-TGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLR
-VAGDELTGLCYVASMDA-ALTGFVLVPL-CYLVLGTSFLLTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNM-FWR
LRATEQPCLAA-----GGLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLC-HR----------
>tr|G1TGY1|G1TGY1_RABIT Uncharacterized protein (Fragment) OS=Oryctolagus cuniculus GN=FZD9 PE=4 SV=1
-------------------------------------------RPALPRGQAGQPRGNAWGAGRRRPPGTLAHTSQGEASRRTGQSSRSCSTSCHGHLRF
FLCSLYAPMCTDQ-TPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDHALCMEAPENATAGPA--EPHKGL--------------------
---GMLPG--ANKFQ-------YVERSRSCAPRCGPG-VE--VFWSRRDKDFALVWMAVWSALCFCSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYS
LAFLIRAVAGASVACDQEAGA-----IQEGLE-TGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHLAAWGLPALKTIVILTLR
-VAGDELTGLCYVASMDA-ALTGFVLVPL-CYLVLGTSFLLTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNM-YWR
LRATEQP---------RDLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQSLC-HR----------
>tr|H6UZX9|H6UZX9_PARLI Frizzled 9-10 OS=Paracentrotus lividus PE=2 SV=1
-------------------------------------------TQGGYCERITIEFCQGIGYNNTKMPNLFGHVTQSEAAPSIHEFHPLVVVGCAEHLRL
FLCSMYAPMCSEH-VRIPPCQSMCEDVRRKCEPVMARFSFSWPESMNCGKLPRG-K-DLCMVAPDTADVDGDTIPTYEPNVNYGGPGDNSASNTTSSAPP
TCLNPQKF----VF-VSQ--------TNSCAPRCDV---D--VYFQRSDKDFTEMWMGVWAILCFVCTSITVLTFLIDRGRFKYPERPIIFLSMCYNIYS
ITYVVRLIVGPAVACEKTS---S---IMEGLD-TGCTIVFLIQYYFFMASSIWWVILTLTWFLAAGMKWGYEAIAAYSSYYHVVAWALPALKTIIALAKH
-LDADELTGMCYIGNHDPDVLTYYVLVPL-IYFAIGTLFILAGFFYLFRIRKVMKNGG-NIDKLERLMVRIGIFSVLYTVPATAVIACYFYQRSNM-YWR
IV--HAPCRPL--EEGGGPMDYSIPSVPVLSVKLFMLLVVGITSGMWIWSSKTVQSWQNWLGRC----------
>tr|A0A0B5CU62|A0A0B5CU62_TRIAD Frizzled B OS=Trichoplax adhaerens PE=2 SV=1
-----------------------------------------------KCQKVQVKFCDLNYYNLTTLPDNITQNQLSDF--QIAHHIIHQNENRCRLARA
FLCLSYLPLCYQH-YEVKPCRELCIKAKSDCDIWNSL---PRNPRFNCSLYLQNKKY-ICFPPPITTDSKPISTNTVHNAVTLSTK----------SSTD
IVHEASREICDRCKH-YS----YDSKSQTCRLRCCG---E--GLFTSKEKKRMNTYMALLSALTFSFTLIAILTAAIRPQRFQYPERILIFMSICYNIYA
LVHLLRVFLRYTVACGKLDSSNR---NSSILSHVPCTVIFIMLYYFDLVASIWLVVLTLLWYLSAKKKWCSEIITGYAVYYHTLSWIIPAVPVAVIILWK
-VSADELTGLCYISSHLAYL-IGFVILPHSLCLLLASVFMIVFYVSTRKIKAQLAQNTASMVKLSRFRGRVLTFFIFYWLLASIIIGCYCYEYTQGPYWQ
PLHRNQSRFNQ-FPCEKRQNIHSDVHISVLAVKLLAQLLRGIVVSFWIASRKTVNEWENIFR------------
>tr|A0A087TSA1|A0A087TSA1_9ARAC Frizzled-4 (Fragment) OS=Stegodyphus mimosarum GN=X975_19887 PE=4 SV=1
----------------------------------------------------------------MSLLNFAGHELQQDAQSQLETFTPLIQYGCSSRLRF
FLCSVYVPMCTEK--PIGPCRPLCESVQELCEPVLLEFGFQWPPVLNCSQFPPTNNKHMCMEGPEHEERKHIP-FRDRNPMRSGIQKGSGNNVASIRSLS
RNMCKHLR--SSDR-Y-Y----YINSTRRCAPACHA---D--ILYSKENKEFAKIWVAIWSCLCFISTLFTIVKFFTNSAQFRYPERIIVILSWCYFIYS
IAFFIRLIGGRDMACHHD--TY----ILGGLD-INCTVVFTLLYFFGMASSIWWVILTLCWFLTAGLRWSTEILERFGTYFHLLAWILPAIKTISILVLR
-VDADELTGTCYVGNQNRQAMLRFVIVPS-TYLAVGIIFLTACGSAIFKNKNLR----TTEEKWEVLMVRVGIFAILYTVPATCVLIADFYEFTTK-QWE
SAN-SI----------Y------RPNVEIFTLKIFMSLVVGITTGVWLYTSKTKQENLQSK--F----------
>tr|H2YUA7|H2YUA7_CIOSA Uncharacterized protein OS=Ciona savignyi PE=4 SV=1
-------------------------------------------------EPIRVTMCKDIGYNLTDMSLSTYIYDQKEAAKSVSQFSPLTRTQCAEEMKL
LVCSVYTPICIPA-NFLPPCRFICERAKQGCEPILKLYNRTWPNLFNCNRFPKFTGSQLCLHFNRSTAEAPVPPRTISNDDGKATPSGVVPPGNGCPCTC
TRPMVKIT----LYG-----------KPNTSGPFCLLNCLR-LNFSEERRKFAESWI-AWSVVCFVITMLTVGTYLIDTQRFKYPERPIIFLSACYMFVS
VGFIIRVVAGHAVACAWHS-------LYQTT--FLCSIVFLLLYFFGMAGALWWVVLSLTWFLAAGLKWGSEAIAGYSQYFHAAAWLIPALKSITVLAMS
-VDGDVLSGICFVGNQNTESLLGFVLAPL-VYLALGGLFLFMGFFNLFRIRNSIKKV-KKTNTLEKLMGRIGLFSLLYMVPSAALVACYFYEHQNR-LWA
KA--CRSHNGQ-----DRHGSANGPEFAVFIVKYSMTLLIGITNGVWIISGKTVASWQRFYQRC----------
>tr|H2M4Z4|H2M4Z4_ORYLA Uncharacterized protein OS=Oryzias latipes GN=fzd4 PE=4 SV=1
-------------------------------------------MEEMTCDPIRISMCQGLGYNVTKMPNLVGNMLQSDAELQLTTFTPLIQCGCSSQLKF
FLCSVYVPMCTDK-IPIGPCGSMCLSVKRKCLPVLLEFGYTWPEALNCSRFPPQ-NNHMCMEGPGDEDPPYQSVHHPSDQ--------------------
---DCQAL----QYT-------WLKQTESCVLQCGY---DN-GLYRRGAKVFTDAWMAVWAVLCFLSTTLTVLTFLLDSQRFSYPERPIIFLSMCCNLYS
VAYLVRLTLGRRVSCDLDAVG-----VQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAAKTIVILIMR
-VDADDLTGLCYVGNQQQEALTGFVVAPL-TYLLVGTLFICAGLMALFKIRSNLQKDG-KTDKLERLMVKIGVFSILYTVPASTVIGCYLYQLSHW----
----------------EFKTSTHDSYVTSEMLRIFMSLLVGITSGMWIWSAKTLHTWQRCSSRL----------
>tr|H2SSV5|H2SSV5_TAKRU Uncharacterized protein (Fragment) OS=Takifugu rubripes GN=LOC101063657 PE=4 SV=1
-------------------------------------------LEEMTCDPIRISMCQGLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKF
FLCSVYVPMCTVK-IPIGPCSSMCLSVKKKCFPVLQEFGFIWPEELNCSLFPPQ-NNHMCMEGPGDEDLPYPPLWNPHHQ--------------------
--QECHAL----QYI-------WLKQTESCTLQCGY---DS-GLYRRGTKVFTDAWMAVWAVLCFLSTTLTVLTFVLDSQRFSYPERPIIFLSMCCNLYS
VAYLVRWTLGRHVSCDLEATA-----VQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMR
-VDADDLTGLCYVGNQQQEALIGFVVAPL-TYLLLGTLFICAGLVALFRIRSNLQKDG-KTDKLERLMVKIGVFSVLYTVPASTVIGCYIYQLAHW----
----------------EFNTIPQDSYVASEMLRIFMSLLVGITSGMWIWSAKTLHTWQRCSTRL----------
>tr|A0A060YHL0|A0A060YHL0_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00016749001 PE=4 SV=1
-------------------------------------------TEEMTCDPIRIAMCQDLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKF
FLCAVYVPMCTDK-IPIGPCGSMCLSVKRKCLPVLIEFGFVWPELLNCSLFPPQ-NNHMCMEGPGDEEAPYHPVRPLPPQE-------------------
--EECQAL----QYA-------WVRRSHSCALQCGY---DA-GLYRREAKVFTDVWMAVWAVLCFLSTTLTVLTFLLDSTRFSYPERPIIFLSMCSNLYS
VAYLVRLTLGRRVSCDLEEAA-----VQEGLKSTSCAIVFLLLYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAIKTIVILIMR
-VDADDLTGLCYVGNLQQEAVTGFVVAPL-AYLLIGTLFICAGLVALFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYMVPASTVIGCYLYQLSHW----
----------------DFRASARDSYVAAEMLRIFMSLLVGITSGMWIWSAKTLHTWQRCSARL----------
>tr|A0A0B5ACP1|A0A0B5ACP1_9CNID Frizzled 4 OS=Corallium rubrum PE=2 SV=1
-------------------------------------------SEKPVCVPITVEQCRRVGYNTTGIPNIFGDTSQSEIERKLLEINILLTSTCAKPVRF
FFCSMFAPMCSTK--LITSCRPLCEYVTERCRPTAEKFGLSWSQTWNCSQFHWANNDGMCMPGHLYNDSDIITTSSTSSKAS------------------
HDGKVSYK--NSHN-Y-I----PLKRDNLWVLLCLR---D--GVFTKKNKDFTELWMAAWAIVCFISTAVAVLTFLIDTQRFRYPERSIVMLAVCYNIYS
IGYILRIIFGRAVSCEDD--ES----TQNELG-PLCAFVFLFLYFFGMAANIWWVILALTWFLAAGMKWSYEAIGSYSNLFHLVAWLLPVIKTVLVLIFR
-VDGDELTGLCYVGNQDLLALTGFVLGPQ-TYLIIGTLFLVAGFVALYRIRLTIQ---TKIDKLDRFIVRIGVFSVFSTVPATCIIASQFYEYSNR-NWL
YGR-T------------------QPNLNVLMLKICMSLFVGIISGMWMWTPKTITSWKNFYRKN----------
>tr|A0A0Q3PDT1|A0A0Q3PDT1_AMAAE Frizzled-10 OS=Amazona aestiva GN=AAES_157732 PE=4 SV=1
----------------------------------------------------------------MSVPEFMPTVSFREFVEQLHEFAPLVEYGCHSHLKF
FLCSLYAPMCTEQ-TPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDNYLCMEAPNNGSDEP---PRGSSMLPPMFRPQRP--SSGHDLQQ
HKDSLSRTSCENKFH-------XVEKSASCAPLCTPG-VD--VYWSKDDKKFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYS
VGYIIRLFSGANIAXDRDSGQ-----IQEGLE-TGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGXEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGLCYVGSMDV-ALTGFVLIPL-CYLIIGTSFILSGFVALFHIRRVMK-TGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
IVATQQKCKMN-----TKMN-NSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVC-SR----------
>tr|H9GKW6|H9GKW6_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=FZD10 PE=4 SV=1
-------------------------------------------GE-SRCQPIAIPMCQDIGYNVTRMPNLMGHEDQREAAIQLHEFAPLVEYGCHGHLRF
FLCSLYAPMCTEQ-APIPACRVMCEQARLKCSPVMEQFTFRWPDSLDCSRLPSKNDNFLCMEAPSNGSEEP---PKPGPLPPLFRPHR-------PHEHE
PPPPKGVPSCGNKFR-------RVEKSASCAPLCSPG-VD--VYWSRQDKRFAAVWIGVWSVLCFFSSAFTVLTFLVDPQRFKYPERPIIFLSMCYCVYS
LGYLIRLFSGASVACDRDSGQ-----IQEGLE-TGCTLVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAVPAVKTIVILVMR
-VAGDELTGVCYVGSMDV-ALTGFVLVPL-CYLVIGTSFILSGFVALFHIRRVMK-TGENTAKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
VLAMQQKCKVN-----TKMS-KSIPAVEIFMAKVFMLLVVGITSGMWIWTSKTLQSWQNVC-SQ----------
>tr|H3BHV4|H3BHV4_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD10 PE=4 SV=1
-------------------------------------------GE-GRCQPIEIPMCKDIGYNMTRMPNLMGHEDQREAAIKLHEFAPLVEYGCHSHLKF
FLCSLYAPMCTEQ-TPIPACRVMCEQARLKCSPIMEQFSFRWPESLDCSKLPNKNDNYLCMEAPNNGSDEP---SKGSSILPPIFRPQRP---SGSQDFI
QKDNPNKGTCENKFH-------HVEKSASCAPLCISE-VD--VYWSKDDKKFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYS
VGYIIRLFAGASIACDRDSGQ-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAIKTIMILVMR
-VAGDELTGICYVGSMDV-ALTGFVLIPL-CYLIIGTSFILSGFVALFHIRKVMK-TGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWK
ILGTQEKCKMN-----TKMN-SSIPAVEIFMVKIFMLLIVGITSGMWIWTSKTLQSWQNVC-NK----------
>tr|H0YT73|H0YT73_TAEGU Uncharacterized protein (Fragment) OS=Taeniopygia guttata GN=FZD1 PE=4 SV=1
-------------------------------------------PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKF
FLCSMYAPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPDTLRCEKFPVHGAGELCVKQNPSSASAKIHTPERTMSRLSGITN---------PFSV
INNPPFFF--------------P-NPNQKCLLPFDPHRL-------SLELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVA
VAYIAGFLLE-RVVC-NERFSE----VAQGTK-EGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALG
-VDGDVLSGVCFVGINNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
RSW-TQSCKSY-IPCPNNHHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|V8NRQ7|V8NRQ7_OPHHA Frizzled-1 (Fragment) OS=Ophiophagus hannah GN=fzd1 PE=4 SV=1
-------------------------------------------PDHGYCQPITIPLCTDIAYNQTIMPNLLGHTNQEDAGVASLPL---P----------
------------L-AGAPGLRSAHEQRLPVAGALMNKFGFQWPDTLRCEKFPVHGAGELCVGQNTSERGTPTP-SLGPEFWTSNPQLRPGGAGRFSCPRV
LKVPSYLN-----Y--------RFLGEKDCGAPCDPGPHGL-MYFGQEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVA
VAYIAGFLLE-KVVC-NERFSD----VAQGTK-EGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALG
-VDGDVLSGVCFVGINNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
RSW-AQSCKSY-IPCPSNHHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|S4S0H2|S4S0H2_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
-------------------------------------------CREMLCQNITVPMCRGIGYNHTYMPNDFNHDSQDEAGLEVHQFWPLVEIKCSPDLRF
FLCSMYTPICLED-QPLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPVLGDNRLCMDYNKSDTTPQPP-EVKPTAPVRSFNPSKNRCESGCACRA
PMVAIGSD----HPLYNRG------SVLNCAMPCHD------PYFTQDERTFASFWIGLWSILCFVSTFTTVVTFLIDMERFKYPERPIIFLSACYAFVS
MGYIVRLVVGHGVICNQEH-------HYET--TALCTVVFLLTYFFGMASSIWWVILSLTWFMAAGMKWSSEAIAGYSQYYHLAAWLLPSVQSVAVLATS
-VDADPLAGICSVGAQSLENLRGFVLVPL-VYLCVGAVFLLAGFTSLVRIRNAIKQQGTKTDKLEKLMVRIGIFSMLYTVPAIAVVACYFYEERSR-GWA
RAL-ICPSCQG----PGSQQQQQRPDYGIFMLKYFMCLVVGITSGVWIWSGKTVDTWKRLCCRC----------
>tr|A0A091CZ01|A0A091CZ01_FUKDA Frizzled-10 OS=Fukomys damarensis GN=H920_15050 PE=4 SV=1
------------------------------------------------------------------MPNLMGHENQREAAIRLHEFAPLVEYGCHGHLRF
FLCSLYAPMCTEQ-APIPACRVMCEQARLKCSPIMEQFHFRWPDSLDCGRLPSQNDNYLCMEAPSNGSDEP---TRGAGLFPPLSRPQRPPGGGAHEHPA
QDGAAARVGCDNKFH-------RVEKSASCAPLCMPG-VD--VYWSRADKRFAVVWLAVWAVLCFFSSSFTVLTFLIDPARFRYPERPIIFLSVCYCVYS
VGYIIRLFAGASIACDRDSGQ-----IQEGLE-TGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMR
-VAGDELTGLCYVGSMDA-ALTGFVLVPL-CYLVVGTSFILSGFVALFHIRRVMK-TGENTDKLEKLMVRIGVFSVLYTVPATCVIACYCYECLNT-HWK
ALAAQHRCRMD-----TRMA-ASIPAVEIFMVKVSMLLVVGITSGVWIWTSKTLQSWQQVC-SR----------
>tr|A0A0B5CM82|A0A0B5CM82_EPHMU Frizzled B OS=Ephydatia muelleri PE=2 SV=1
-------------------------------------------STNSTCVGGIPTQCIVSDYQSASFPNNVSQDINN-L---LL-YSKYHVANCSALANL
YVCLALFPRCSPQLGAGPPCGSLCRAAVSDCQGKLSSGDD-KCLFSNCAQFPD--T--NCISLDSLLLVNYSL-SSTPT---------------------
---TVVTSATLET---------YAAVNGSCPRR--D---R--SYFTQQEKTFALGWVAFFSFICFLSTLITILTFLLNPSRFEYPWRPVVYLALCFMVHA
FGYFLAMMVGRQLTCPGNNF------ATWTWEYAPCLVVFILLYYTMMASFLWWLTLTFGWFLTTVYRWSHEAVSRLAPLFHITAWVLPLVMTVLLLGNK
-VGADELTAVCFVVMEKDYGLMLGVILPLLLFLLAGIFFLVAGFISVLRIRDLMHH-GTEMDRLEKLMVRIGVFVTVYIGPAGVMIGCYIYELTSKPGWK
SMADT-TC----TDCP-------SPNTAVFMTRVFMFLLIGTLTGVWIWSXKTLQSWVSIPS------------
>tr|Q70LH3|Q70LH3_SUBDO Frizzled receptor OS=Suberites domuncula GN=frz PE=2 SV=1
-------------------------------------------TAFGSCVP-APTAC---LYSSTAYPNNVTTTSMMSL---IAYQPFVNVIDCSPYSQL
FICLSLAPVCTSG--PRHPCESLCDLVLASCSDKIQQLPD-TDCLLNCDRYPS--T--GCVDTDDPLVLAIQS-INPLTTIP------------------
-AITQTPHTTEPS---------TANSSGECP----E---V--SYFTDSAKSFAQGWLAFWALICFISTTLTIATFVLDPSRFQYPWRPVVYLSLSFNLHS
LTHFFSKGLGRLVTCPGNQF------ITWTWGHTPCILVFGLLHETMMTAFLWWLMLSFSWFLASAFSWSSEAVSHLAPFYHVIAWVLPLVLTIILVATR
-VGADELTATCFIVRDE-YALLLGVIIPLVACLITGVVFLVIGFVSLFRIHSIMRH-STESSILEKLMIRIGIFVVVFILPAVIVVGCFMYELISRPFWT
PIS-E-PC----NDCV-------LGNPAVFMTRLFMFLLTGILTGVWIWSKKTLLSWRNLPQ------------
>tr|I1G9T3|I1G9T3_AMPQE Uncharacterized protein OS=Amphimedon queenslandica GN=FzdB PE=4 SV=1
-------------------------------------------LI-------QEATCNYTLRNLSIYPNQVINETTEIVTLVNALDSSLRSCSSNADRSG
FICAAFFPSCDSG----GPCSSFCKKIRQDCSNTLPFLPSTVSWIFNCTRYEP--NS-PCIQPISIEPTSSSSSTSSIVVIS------------------
TPLPSQTPSTTPS---------TNESSVGCPPP--S---S--SYYTDGMKSFTKGWIATWSTLCFLSTSLTLLTFVIKPSRFEYPWRPIIFLALCFNIHS
LGYFFSLALGRIITCPGNNY------SKWSWSHIPCLLNFGLLYYSMVSAFLWWLALTLSWFLSAVFKWSNESVGRLAPFFHVTAWVVPLLMMISLVAAQ
-ISADELTGTCFIVRDD-FGLLIGVIIPLLLFLSIGLLFLIIGLISVFRIRRFLHN-KKESIVLEKLMFRIGIFVAVYVLPAGAVISCYIYELAKVPDWV
TLNEAESCSD--GGCQ-------KASPIVFIIRIFMFLMIGILTGVWIWSKKTLDSWRSLGN------------
>tr|U6PBM8|U6PBM8_HAECO Frizzled and Frizzled protein domain containing protein OS=Haemonchus contortus GN=HCOI_01140600 PE=4 SV=1
-------------------------------------------TSKGKCQPIEIPLCKEVPYNYTYFPNPYLQQDQQSLQTNTEHFKPLIKTKCNRNIQF
FVCSVFAPMCPEG--AVTSCRSVCEQVKADCSSILEEFGISWPEPLDCSRFPQEP--DLCMNPDEDRHSYEKTSSVHRHRLRPS---------------S
LSCPHDLI--DI-----D----PLDNEGVCAYKCGA---D--VMFSSEEKAAARTWMIMWGGFDFSISLFTFLTFLIERNRFRFPERCVFYISLCFMLYS
IPYLFPLIMQYARACDKL--I-----VFSGFE-TNCLFSFVFTYYFGTASCLWWLMFAFTWYLSASRKWVPEGIDACSSYLHLVAW-TAALMTIVVLVMQ
-VDASELSGICSVGNTDPTALLAFSLIPR-VFVFFGTCFVIAGFASMCRERDSFRRRG--TSKLDKLMFKMGLFCLLYIFPAVTQILCDIYAYNNV-RWY
PTT-I-ACKSNG----VECHRPHLPQAEIYHLSLMMSLAVGASCGMWVLSPKTLMSWHRVLCC-----------
>tr|E3LM68|E3LM68_CAERE CRE-LIN-17 protein OS=Caenorhabditis remanei GN=Cre-lin-17 PE=4 SV=1
-------------------------------------------AAKGKCIPIDIDLC-DLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHF
FICSVFAPMCPIGA--VTSCKSVCEQVKADCFSILDEFGIGWPEPLNCAQFPDPP--ELCMKPTEDEISGGFSAPRVPSKVS------------------
SSSSSKPTGCPSDLV-DV---DPHDPKSHCAFSCQS---N--VMFSTDNKRMVRSWSIWFAAANAGVAFFSFLTFAIDRKRFRFPERCVFYLSLCIFLSS
LPYLSPLIIDAIRSCHALGNG--R-SSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFN
-VDASELTALCSVGNLNSIALLWFVIVPRIICIVIGTCFIVGGFASMCRERIS---FR--TSKLEKLMAKMGFFCALFILPNVIELVCQCYKFMILTQWT
R-M-TIECKQQLGACHRPQA-------EIYMAAVLSNLTTGLSCLVWVLSAKTVNSWKNFIFCG----------
>tr|W5UCV3|W5UCV3_ICTPU Frizzled-4 OS=Ictalurus punctatus GN=Fzd4 PE=2 SV=1
-------------------------------------------ESESACEPIRMSMCRDLGYNVTRMPNLVGNVLQADAELQLSTFTPLIQYGCAKQLRF
FLCSVYAPMCTEK-ELIGPCGSMCLSVQRKCLPVLQEFGFSWPDLLNCSLFPPTNDAHMCMEGPGEEDEDDVRFPSVRTLRPRHGLDAECI-PLDHDPGD
DPTPPDRY----VW-SKR--------SSSCVLQCGY---DS-GLYSRSAKTFADAWMALWAGLCFVSTSFTVLTFLLDSGRFAYPERPVAFLSVCYNAYS
AAFLVLLAAGRRVSCDADE---A---ARDGLK-SGCAVVFLLAYFFGMASSVWWVILTLTWFLAAGLKWGHEAIEMHSSYFHVAAWAIPAIKTIVVLVMR
-VDADDLTGLCYVGNQNLEALTGFVVAPL-TYLAVGTLFIAAGLVSLFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYTVPASCVVACYFYRVSNW-DFQ
RA--------------------SDSYAAAEMLRIFMSLLVGVTCGMWVWSAKTLQTWKRRWTRL----------
>tr|F7B4M1|F7B4M1_CIOIN Uncharacterized protein OS=Ciona intestinalis PE=4 SV=2
-------------------------------------------RPKFKCFPISEPLCSDFPYNYTTFPNILGHDNADDASDVLYEYKLLLDTHCSTHLRF
FLCSLHFPMCTPK--AIPGCRSMCEKVRADCEPVMRVGGVQWPDTIDCSKLPMRNEKRLCMVPPGESPNGEAPKVDTNPQPPSVTLDESGAQDKNQFVTI
SQPKPRPN-----K-C-K----NPNKMKQCVPRCEKT-TD--ILFSSNHKQIAYWLLFSFSLLCFISTVMTVCTFMIDSKRFRYPERPIIFLSICYCVYS
VAYLVRSVNGPNMACMEDITHP----VKGGIQ-TGCTAMFFVLYYFGMAASAWWVVLTLSWLLSAGFKWGHEAIEAYGFYFHLAAWLLPAGQTIVVLILG
-VDGDELTGVCYVGNLEPESLMYFVIIPL-FYLITGTVALVFGFGYLFKIRRVIRHQG-SAGKLEKLMWRIGVFSVLYTVPAACVVAVNFYQYQNL-VWM
SHA-R-----------VNTLPDSIPSLPIFGIKIFMSLIAGITSGMWIWSGKTVESWRKFYKTC----------
>tr|H2YBE7|H2YBE7_CIOSA Uncharacterized protein OS=Ciona savignyi PE=4 SV=1
-------------------------------------------------------------YNYTTFPNILGHDNPTDASEVLFEYKLLLDSHCSTQLRF
FLCSLHFPMCTPK-VAIPACRGMCEKVRRECEPIMELGGVTWPESIDCSKLPLRHQDRLCMGPPGESPDNPTEADNPPTITTFTKRTNRTKKKAGKEPIC
DSPTKPNN----MQ-KSK----QISFLRKCLPRCEKG-VD--VLFSSRHKEIAHWLLFGFSLLCFISTTVTVCTFMIDSKRFRYPERPIIFLSICYCAYS
VAYLVRSANGPHPIACVGG---E---AKGGFQ-SGCTAVFFVLYYFGMAASAWWVVLSLTWLLSAGFKWGHEAIEAYGFYFHLAAWLIPAVQTISALVLG
-VDGDELTGVCYIGNLDPESLMYFVIIPL-FYLLTGTVALVFGFGYLFKIRRVIRHQA-AAGKLEKLMMRIGVFSVLYTVPAACVVAVNFYQYQNF-VWM
AH--RIPCKGA----AKLSLSESIPSLPIFGIKIFMSLIAGITSGMWIWSGKTLESWRKFYESC----------
>tr|E4WSI5|E4WSI5_OIKDI Uncharacterized protein OS=Oikopleura dioica GN=GSOID_T00000721001 PE=4 SV=1
-------------------------------------------GRPPKCEEIKVPMCQGIGYNYTSMEIPFHLQTQMEVIAEAHQFYVLVQKGCSAELRP
FLCGMYTPVCMPD--FLPPCRFLCERARAGCEPIMNEHGFEWPEKMNCELLPE--N-QLCNDFGRKEIEL----SAQIPSTDSRSSSCRNCIDLSKSSQN
FEADLRAW----G-------------VSGCARTCQSPTQ-------DER-RFLDSWLS-GAVIVAIATVIVLGTFCLDPQRFSYPERPILYLSLCYLFIA
AGYILRYSVGSSISCDAAHPER----ALPGRG-AYCNLVFVLTYYFGMASSIWWVMLTFAWFLAAGMKWSCEAISNYSSYMHAVAWTIPALQTILIMVTN
-VDGDPFLGICSVGNNNIEQMHTFILAPL-VYLSAGGLFLIVGFFSLFRIRNTMKKQQ--TKKLEKLIIKIAIFSVLYMIPASIQVFCYFYESEFR-AWE
KEL-NCHNCGS------------ETSYLIIFLKPAMSFLVGIAAATWICCDKTLRTWKRM--------------
>tr|G9BBX0|G9BBX0_PARLI Frizzled7 OS=Paracentrotus lividus PE=2 SV=1
-------------------------------------------ITHGRCEAITIPLCEDMPYNMTIMPNLLNHQHQEDAGLEVHQFYPLVKVQCSEDLKN
FLCSMYAPVCTLL-SALPPCKSLCLSARNGCESLMNKFGFSWPASLSCDQFPEGG---LCFDRNRTEERVTIPSTKTPNITKPTEPSVTK--DIPFTCPL
QLTVDHDW----DYSFM--------RAQNCGAPCNM----Y--FHTEKEQKFARYWVGCWAFVCAVSSLFTVLTFLIDRSRFRYPERPIIFLSGCYFVIS
VVFIAGFFLE-RVSCNKPYLPGG--GLVQGAK-QWCTILFMLLYFFQMASCLWWVVLSLTWFLAAGLKWGHEAIERNSQYFHFAAWSIPAGKTIGVLATG
-VDGDSLSGVCYTGIRDMNALRGFILAPL-VYLIIGSLFLCAGFIALFRIRTFMKSDGK-TDKLEKLMIRIGIFSLLYTVPATIVIGCYIYEQANR-VWE
WF--LGNCHR-F-ACPQNSLNLPGPDYLVFIVKYLMMLIVGITSSVWVWSGKTLRSWTQFYSRL----------
>tr|H3BHZ5|H3BHZ5_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD9 PE=4 SV=1
-------------------------------------------RE-AKCEPIEIPMCQGIGYNMTRMPNYMGHENQREAGIKLHEFAPLVEYGCHVHLKF
FLCSLYAPMCTDQ-TSIPACKPMCEQAREKCAPIMEQFSFGWPDSLDCSKLPTKHDNALCMEAPENATTGEP--HKGQGMLPVAPRPR------PPGAGE
GRSPGPLGTCENKFQ-------YVEKSLSCAPKCSPG-VD--VYWSREDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDPPRFQYPERPIIFLSMCYNIYS
VAFIIRSVAGANIACDKENGE-----IQEGLE-TGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEAHSSFFHMAAWGIPAMKTIVILTMR
-VAGDELTGLCYVGSMDV-ALTAFVLIPL-CYLVIGTSFILTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATCVIICYFYERLNM-YWK
FRALEQNCRVF-----GRLE-ASVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQKLC-SR----------
>tr|F6TMZ2|F6TMZ2_XENTR Uncharacterized protein OS=Xenopus tropicalis GN=fzd9 PE=4 SV=1
-------------------------------------------RE-AKCEPIQIPMCQGIGYNMTRMPNYVGHESQEEAAAKLQEFAPLVEYGCHIHLRF
FLCSLYAPMCTEQ-TSIPACKPMCEAARQKCAPIMESFQYVWPESLDCDRLPSKNDHALCMEAPENATNGDPP-TNGHGMLPVAPRP---------PRPS
GSGIGISSRCANKFM-------YVERSGVCAPRCIPG-VD--VYWSSGDKDFALVWMAAWSGLCFISTAFTVFTFLLHPQRFQYPEKPIIFLSMCYNVYS
TAFLIRAAAGASIACDREGGA-----IREGLE-SGCTLVFLILYYFGMASSLWWVVLTLTWFLAASKKWGHEAIESHGSYFHLAAWGIPAIKTIIILTMR
-VGGDELTGLCYVGGSDP-ALTGFVLVPL-CYLVTGTSFLLTGFVALFHIRRVMK-TGTNTEKLEKLMVKIGVFSILYTVPATCIIVCCFYERLNL-HWD
SRAREESCRTV-----GSLP-HSIPSVAVFMLKIFMSLAVGITSGVWVWSSKTLQAWQGILCQR----------
>tr|A0A0N5A1U9|A0A0N5A1U9_PARTI Uncharacterized protein OS=Parastrongyloides trichosuri PE=4 SV=1
-------------------------------------------NTKNRCVPISLPIC-DIPYNYTYIPNPIFPHDPATLHLQTDHFKPLIRTQCNPHIKF
FICSVFAPMCPESA--VTSCKSVCQEVKRDCIKIFHEFDIQWPESLDCDKFPEEP--ALCMKPNPIEMESSHYSSSHSSKNFPSKN----------NLET
IFSNRLAPSCPADLV-NL---DPIDKNASCAFKCNG---D--VMFGRGQKSEANHWLFIIAMVNIIITTFTVLTFLIDKKRFRFPERSIFYIAACYTFYC
LPYLMKYFYSYDAGCSFTNGG--Q-RIESGVDNRLCALSFIFSYYFSTAGSLWWLTLTLTWYLSAGRKWVPEGIESFSNYLHLFTWGISSILTIAVLITN
-VDASELTGICSVGNLNPFSLLAFVILPKV-FVLTGSALIAFGFSSLCRERDS---FR--TTKLDKLLIKMGIYSLLYIGPMIVTLSCDFYHYLVLQEWY
P-A-TIACKMYRGGCRRPQY-------EIYILGIGMQMLIGISTSIWIFSSKTISSWKKFICCA----------
>tr|A0A090LJR2|A0A090LJR2_STRRB Frizzled-4 OS=Strongyloides ratti GN=SRAE_2000241100 PE=4 SV=1
-------------------------------------------TNKNRCVPITLPIC-DIPYNYTFIPNPIFPHNPATLHLQTDHFKPLIRTQCNPHIKF
FICSVFAPMCPESA--VTSCKSVCQEVKKDCIKIFTEFDIQWPESLDCDKFPEEP--SLCMKPNPIQMDNTYYNHHFQQKYGSNNN-----------LET
IFTNRLAPSCPADLV-NL---DPGDRNASCAFKCNT---D--IMFSKGQKNEADYWLFIISIINITITTFTVLTFLIDKKRFRFPERSIFYIAACYIFYC
LPYLLKYVYSYNVGCIFTNGG--Q-IIESGVDNRLCTISFIFSYYFSIAGSLWWLTLTLTWYLSAGKKWVPEGIESFNNYFHLFTWGVASILTMAVLITN
-IDASELTGICSVGNLNPFSLLAFVILPKS-FILTGSGLIALGFSSLCRERDS---FR--TTKLDKLLIKMGLYSLLYIGPMLVTLACDFYHYLVLQEWY
P-A-TIACKMYRGGCRRPQY-------EIYILGIGMQMLIGISTSIWIMSLKTITAWKNFICCR----------
>tr|A0A0N5BPC9|A0A0N5BPC9_STREA Uncharacterized protein OS=Strongyloides papillosus PE=4 SV=1
-------------------------------------------TNKNRCVPVTLPIC-DIPYNYTFIPNPIFPHDPATLHLQTDHFKPLIRTQCNPHIKF
FICSVFSPMCPEAA--VTSCKSVCQEVKRDCIKIFTEFDIQWPESLDCDKFPEEP--ALCMKPNPIPMESDHYNHHAPQKYGSNKN-----------LET
IFSSRLVASCPADLI-NL---DPADRNASCAFKCNS---D--IMFSRGQKNESNYFLFVIALVNIVITTFTVLTFLIDKKRFRFPERSIFYIAACYTFYC
LPYFLKYVYSYDMGCSFTNGG--Q-LIESGVDNRLCAISFIFSYYFSTAGSLWWLTLTLTWYLSAGKKWVPEGIETFTNYLHIFTWGLSSILTMAVLITN
-IDASELTGICSVGNLNPFSLLAFVILPKS-FVLTGSLLVILGFSSLCRERDS---FK--TTKLDKLLIKMGLYTLLFIGPMVITLACDFYHYLVLQEWY
P-A-TIACKMYKGGCRRPQH-------EIYVLNIAMQMVIGISTSIWIISFKTISSWRNFICCD----------
>tr|I6WNQ0|I6WNQ0_BUGNE Wnt receptor frizzled-like protein 4/9/10 OS=Bugula neritina PE=2 SV=1
-------------------------------------------DDMGRCEPIRIDMCSHLKYNMTSMPNSLGHISQEEVIAELRPYSQLVNFNCSQHIEF
FLCSLFVPMCTMQPLVINVCRSMCLQVKSDCDSILKKLEVRWP--LNCSELPESNVEQLCMAPRGNQLPSHGLSTHTPPDVEEAVTRQRVSITPKQHTPS
TSCPDQYV--RYTN---L----CDPACKDCVPKCQH------VFYTQKHKNFAYTWMAIWASLCIASTLFTILTFCIDPRRFRYPTRPVIFMAFCYLIYA
LSYFIPLFIPRKIICKSD--VQ----VVNGME-TLCVIIFLVQYYFGIASHVWWLILTFTWYLAASRKWVLEAINSIACYFHLFAWAVPAVLTVVILVTG
-VDSNELTGMCYVGNHDKWSLLIYIIIPT-FLCLVGEILMLAGFVSVLRIRTNLKTHVASVRKLEKLMAKIGVFAIFYTVPTVCVLGSNIHEFINM-TWR
CMS-SLT---------ST-LVGSIPTVEIHILKISMSLIVGVFIAMWVLNSKTLQTCERKCSRK----------
>tr|A7SCF4|A7SCF4_NEMVE Predicted protein OS=Nematostella vectensis GN=v1g168924 PE=4 SV=1
-------------------------------------------VPNSKCTPITIPLCMGIGYNATRFPNFLAQESQEEAAKRIHEFKPLIAVNCAPLLRF
FLCSVFVPMCTKE-VPIYACRSMCESARDGCSPMMQRFGFNWPDTLDCDRLPKKGDTKLCMAAPNIKQTAPLNESDIWSNFESLGPEF-------KKINN
TGPLRYKY----TY-VEK--------YDQCVPQCKS---D--LMFSSNNKRFANVWISVWSVLCFISTAVTVLTFVIDTSRFKYPERPIIFLSLCYNLYS
LGYIVRVTAGREVICDETE-------IRAGMNAACCSVVFLLLYYFGMASAVWWVVLTFAWFLAAGRKWGQEAIERKATYFHAVAWTVPAIQTIMALIMR
-VDADELTGLCYVGNMDYENLANYVLTPL-LYLLVGTFFLLAGFVSLFRIRTVLKNKE-NTDKLEKLIVRIGVFSVLYTIPVSAVIACSFYEYNNM-VWK
VR--FNTY-----ICRGDCLENYGPSIEVFIVKYFMLLIIGITSNMWIWSTKTFKSWRKFYSKR----------
>tr|A0A0B5ABR5|A0A0B5ABR5_9CNID Frizzled 3 OS=Corallium rubrum PE=2 SV=1
-------------------------------------------AKKVVCERLRIPLCENIGYNMTTMPNRMGNEDQLEAKSKIEDFRPLIKVGCARHIKH
FICSVFAPMCNED-YPIVACRSMCEEARKGCEAVMKRFGYPWPDGFKCKSFPVSNQGKICIRNPRLETDAPNPNTKAVPTVSTPRLMVSGGIKNPTVLPG
NCANYKKF----VY-VEK--------KERCAAKCGE---D--VYFDKANKQFSDVWLLIWSTICFVSTMVTVLTYLVDRSRFKYPERPIIYLAFCYNLYS
AAYLIRLIAKPGISCSADG-------IIDGLN-AGCSIVFLLLYYFGMASSLWWVLLTLTWFLSAALKWSQEAIANKSTYFHAVAWVIPAIQTITALSTR
-VDADELTGLCYVGNQNVESLAGFVLAPL-IYLVVGTTFLLAGFISLFRIRSVLKDRD-NTRKLEKLMVRIGVFSVLYTLPATAVIACFVYEYSNM-SWQ
KD--TNCM-----KAVTDCNLATKPKEEIYMVRHFMSLVVGITSGMWVWTLKTCQSWQLCYYKN----------
>tr|A0A0L8GT36|A0A0L8GT36_OCTBM Uncharacterized protein OS=Octopus bimaculoides GN=OCBIM_22028628mg PE=4 SV=1
-------------------------------------------EVVRTCDPIEIPTCKRQGYNVTGMPNLAGDDKQRDAQLQLNTFSPLIQYGCSSQLTF
FLCSVFVPMCTDK-EPIGPCRPMCESVKRKCQPVLQEFGLSWPHILNCSKFPPNNNDHMCMDGPGEKEEDENKDHLEPDKSDKRPTNPGWKHSRPSGSCS
HKRHPENY----IF-VNR--------TERCALRCGR---H--DAFTYNDKEFSDVWMAIWSILCFSSTLFTVLTFLIDSQRFRYPEQPIIFLAMCYNIYS
IAYIVRLIAGRNISCDVHREVRR---IQEGLE-TDCAIVFLLLYFFGTASALWWVILTVTWFFSAGLKWSHEALQVHSSYFHLTAWAIPAIKTIIILIMR
-VDADELTGICFVGNQNDNSLIGFVIGPL-FYLFVGTAFLVAGFISLFGIRRQARNGG-KTDKLEVLMVRIGVFSVLYTLPATCVIACLFYEYTNR-DWY
SA-------------------TSKPSIEIFMLKIFMNLIVGITSGMWIWSSKTIHSWRKFVGRF----------
>tr|V4AZI8|V4AZI8_LOTGI Uncharacterized protein OS=Lottia gigantea GN=LOTGIDRAFT_201339 PE=4 SV=1
-------------------------------------------ENVRTCEPIRFEMCKGLGYNVTGMPNLVAHTDQQDAGLQLQTFTPLIQYGCSKQLKF
FLCSVYVPMCTEK-DPIGPCRPMCESVRSRCQPVLNEFGYPWPAALNCSKFPARNDTHMCMDGPGDEIEDDL--PYPRKPNVPN--------------CE
KFRNPSKY----IF-INR--------TERCALLCSE---N--DAFTSKDKLFADVWMAIWAGLCFVSTFFTVLTFLIDSQRFKYPERPIIFLSMCYNIYS
IAYIVRLLAGRSIACDTDS--QS---IQEGLE-TDCAIVFLLLYFFGTASSLWWVVLTFTWFLSAGLKWGHEAIQLHSSYFHLFAWALPAIKTIVILVMR
-VDADELTGICYVGNQSTQMLLGFGVAPL-VYLILGTAFLIAGFVALFRIRKQVRCDG-KTDKLEVLMVRIGIFSVLYTVPATCVIGCLLYEYLNR-SWY
LY-------------------QTSPNIEIFMLKLFMSLVVGITSGMWIWSAKTVSSWKNFFKKI----------
>tr|K1PCJ3|K1PCJ3_CRAGI Frizzled-4 OS=Crassostrea gigas GN=CGI_10009113 PE=4 SV=1
-------------------------------------------EIVRKCDPIRIEMCKGLGYNVTGMPNLVGHDLQQDAELQLQTFTPLIQYGCSQQLKF
FLCSVYVPMCTEK-EPIGPCRPMCLSVQRRCQPVLHEFGFPWPVALNCSKFPPKNDHHMCMDGPGESAVEDNVRKPTFRPPVHKKE----------HQCG
EFRHYHMY----TY-INR--------TGRCALKCNE---N--AAFTTEDKYFADIWMSIWSGLCFVSTLLTILTFVIDSQRFKYPERPIIFLSMCYNIYS
IAYIVRLIAGRSIACDRDT--AS---IQEGLE-TDCAIVFLLLYYFGSAAALWWVILTLTWFLSAGLKWTHEAIQLHSSYFHLAAWALPAIETIIILVMR
-VDADELTGICYVGNQNTQTLLGFSVAPS-VYLVVGVAFLIAGFIALLRVQSQDRVNG-KSAKIENLMIRVGIFSLLYTIPAAIVIACLLYEYASR-SWY
LR------------------IHSEPKMEIFMLKVFMTLVVGITSGMWIWSSKTINSWRNFAVKL----------
>tr|T1FXD5|T1FXD5_HELRO Uncharacterized protein OS=Helobdella robusta GN=HELRODRAFT_63277 PE=4 SV=1
-------------------------------------------DHRPACEPIRIDVCKDMAYNLTMMPNIFKHQTQKDAQEEVSTFSSLITFNCSPYLKI
FICTLYAPICTDL-SILTPCRSLCEEVRQSCEKNMNLFNYQWPPSWNCAQFNK----PTCVGENKTQLLKDLDKRQPNTKIKNNGHTNALDKLMPLQCLP
KMKVPKNY----QYSIKI----NN-KIKDCGMPCSFDGD-S--FFDASKKAFAWYMVGTASIICLISTLFTLITFLVDMDRFPYPERPIIFLSGCYLAVS
ISFIIGFATG-NVACVGPFSSEES-SVIQGKD-ELCTVVFVILYYFSMASCLWWVILTITWFLSASLKWGQEALNKNSHYFHLIAWSLPAVQVIAILALD
-IEGDNLVGVCYVGVYDEKALVIFVIVPL-VYLLVGIFFLMAGLFSLFKIRTAMKQEGG-TEKLEKLMLRIGVFSLLYTVPAGVVVACHIYELTLR-DWL
MA--TKTCYKYL-SCPVLGDAKNSPDFTIFMIKYMMMLLVGICSGFWVWSGKTFLSIRRKLCCC----------
>tr|A0A0B2VHM5|A0A0B2VHM5_TOXCA Frizzled-10 OS=Toxocara canis GN=FZD10 PE=4 SV=1
-------------------------------------------ASRSRCEPIEIPLCKDIPYKYTYFPNSLPQPDQQSLQTQTEHFKPLIKTKCNPHIKF
FVCSVFAPMCPEH--AVTSCRSVCEEVKRDCVSILEKFGIEWPEPLNCSRFPQAP--DLCMKPTNEHNSYLGPDQLESEQRDSLASIEG----RILAKWI
PTCPNDLV--NL-----D----PTDRQGHCAFQCNR---E--GMFDESKKEFARFWMLLWASINLAITTFTVLTFLIDRQRFRFPERSIFYLSACYMLFS
LPSLSRAFITYRSACERI--P-----IIGTLD-TPCVISFILTYYFSMASSLWWLMLTFTWYLSAARKWVPEGIDAWSSYLHLVAWALPALLTIAVLTTH
-LDASELTGVCSVGNADPWALLGFAIAPK-IFVLVGSCLIVAGFSSMCRERDSFRRRG--TSKLEKLMVKMGIFSALYIIPAITMVVCDSYHMFIL-QWH
PTT-I-ACKQYG----AECKRPQLPQAELYILNIFMSLAVGISTGMWTLSSKTFHSWQRVLCC-----------
>tr|Q5J0Z5|Q5J0Z5_PRIPA LIN-17 OS=Pristionchus pacificus GN=lin-17 PE=2 SV=1
-------------------------------------------STKGRCVPMQHKMC-DIPYNMTYHPNPISATEQ----SQIDHFNPLIKTKCHPHIKF
FVCSVFEPMCPDQA--VTACRSVCEEVKRECVSIIEEFGLQWPELLECSKFPAQP--DLCMQPMDNVGQSARPTMSHFPR--------------------
---LSSSQSCPSFLV-DT---DEEDPMAPCALPCKG---D--VLFSTMHKNQLSKWLPGVAIASCAFSAFAFLTFLIDRSRFRFPERCIFYLSLCYLCYS
LPFLVVGLDPQQPACSQTNLH--KTRLLGHMDSSLCTISFFLTYYFSMSAALWWFMFAFTWYLSATRKWVPESLEAASIRVHVVAWFGPLVAAIVVVMTH
-VDSSELTGLCGVGNTNRVALLFYSFLPRAVIGCVATLFLLTGITSMCRERNN---FK--TSKLDKLMLKTCLFLVVYVVLWLATLAADLYHYAQLQAWQ
D-A-TIGCKQSL---AQPNG-------DIYLMQVLAPLFAFIGPFIWXFSLKTFSSFKRRICCC----------
>tr|A0A0K0JQP1|A0A0K0JQP1_BRUMA BMA-LIN-17 OS=Brugia malayi GN=Bma-lin-17 PE=4 SV=1
-------------------------------------------ASRSRCEPIEIPLCKDIPYKYTYFPNSLLQPDQQSLQTQTEHFKPLIKTNCNPHIKF
FICSVFAPMCPEH--AVTSCRSVCEEVKRDCVSILLEFGIDWPEPLNCSRFPEAP--NLCMKPTNDQNSYLGPEQFDTDHRESVTSLEG----RIFSKTM
ISCPHDLV--NL-----D----PTDRRGLCVFQCNR---E--GMFDVSKKEFARFWMLLWASINLGVTAFTVLTFIIDRQRFRFPERSIFYLSACYMLFS
LPPLSRAVFPYRIVCDKL--P-----IAGTLD-TSCVMSFILTYYFSVASSLWWLMLTFTWYLSAARKWVPEGIDAWSSYLHLVA-ALPAILTIAVLTTH
-VDANELTGLCSVGNVDPWALFGFIIVPK-IFVVVGSCLIVAGFSSMCRERDSFRRRG--TSKLEKLMVKMGIFSALYVIPAITIIICDSYHMFIL-KWH
PTT-I-ACKLHG----IECKRPPLPQAELYFLNIFMSLVIGISTGMWTVSSKTFHSWQRAICC-----------
>tr|A0A0M3JXC1|A0A0M3JXC1_ANISI Uncharacterized protein OS=Anisakis simplex PE=4 SV=1
-------------------------------------------ASRSRCEPIEIPLC-DIPYKYTYFPNSLPQPDQQSLQTQTEHFKPLIKTKCNPHIKF
FICSVFAPMCPQHA--VTSCRSVCEEVKIQVTYLNRKFGRESRFARGGNRFPQAP--DLCMKPTNEHN--SYLGPDQLENDQRDPLS---------SIEG
RIFAKSIAECPNDLV-NL---DPTDQNGYCAFQCNR---D--GMFDDSKKEFARFWMLLWASINLAITTFTVLTFLIDRQRFRFPERSIFYLSACYMLFS
LPSLSRAFIPYRSACERLPTG--Q-SIIGSLDNTPCVLSFMLTYYFSIASSLWWLMLTFTWYLSAARKWVPEGIDAWSSYLHLVAWALPALLTIAVLTLH
-LDASELTGVCSVGNADPWSLLGFVILPKLLFVLLGSCLIVAGFSSMCRERDS---FR--TSKLEKLMVKMGIFSALYIIPAITMVVCDSYHMFVLMQWH
P-T-TIACKHYKGVCKRPQFVLNDVSAELYVLNIFMSLAVGISTGMWILSSKTFHSWQRVLCCG----------
>tr|A0A0B7AQP5|A0A0B7AQP5_9EUPU Uncharacterized protein OS=Arion vulgaris GN=ORF130825 PE=4 SV=1
-------------------------------------------RPHPRCEPINVKMCKDMRYTMTRMPNLAGQDNQIEADARIQDFLPLVQTNCSGLLKF
FLCSLYAPMCTELTLIIPACRSMCLQVKAKCEPLLQTFNFEWPDMLACDKLPEKSDNNLCMAAPNTTEDTDTGSRTLIRPNIEEAGIHQILGSQTGHKKV
PDSCPSRF----VR-VDN----IPRSDNTCAPRCDV---D--VLFRQEDKDFADVWMLVWASLCTFSTLVTVTTFAVDSSRFKYPERPIIFLSMCYLIQS
AAYIIRAATGPSVSCDTTR---D---IQEGLD-TWCIIVFLLLYFFGMSSAVWWVILTITWFLAAGRKWGQEAIAALSSYFHLAAWAIPAVQTIVILTMR
-VDGDELTGLCYVGNQDPDALTAFVIVPL-IYLAAGFIFILAGFTAMLRIRHDLKQEGANIRKLEKLMARIGVFSALYTVPATCVIGCHFYERLNF-RWR
QQ--RLPCPSST-PAEPQPLEQSIPTVEVYMLKLFMSLVIGITSGMWIWSVKTIASWKTFCSRR----------
>tr|T1G984|T1G984_HELRO Uncharacterized protein OS=Helobdella robusta GN=HELRODRAFT_95849 PE=4 SV=1
------------------------------------------------------------------MPNIAEQTNQRDAELQMYEFVPLIRTKCSPWLKF
FLCSVYFPFCTEQTLIIPPCRSMCLGVKENCEPILHQVSLKWPDVLDCGKLPEKNDSNLCIEPPLGYHDK----KDFKC---------------------
---PPRYT--NVEI-M-I----RGMSNDTCAPRCQV---D--VMYRFTDKKFAEIWMILWAVLCLVSTLFTFLTFILDTTRFEYPERPIIYLSMCCLVYS
CGYIIRFARGLDVSCIES--R-----IQEGLE-TWCVVVFLILYYFNMAGCIWWVILTSTFYFSAAKKWSREALQKANNYFHVISWTLPAVLTTIVLTMR
-LDGDELTGLCFVGNQDMDSLLTFVLFPN-VFLIIGVYFIIGGFVAMFRIRQDLVSDG-DVKKFEKLMMKIGIFSILYTLPDICVVGCLFFEWLNF-DWR
AAA-YLTPCYK-----FDSLEKSIPAVEVKVLKIFMSLVIGTASGIWVWSPKTVQLWTKFFKKF----------
>tr|V4BK78|V4BK78_LOTGI Uncharacterized protein OS=Lottia gigantea GN=LOTGIDRAFT_228923 PE=4 SV=1
-------------------------------------------PHPPRCEPITIPMCKDMKYNTTRMPNLVGHENQKDAAIQVHEFLPLVQFGCSRLLKF
FLCSLYAPMCTELTIIIPACRSMCLKVKAKCEPVLTKFAFPWPKMLSCDNLPEKSNETLCMEAPEEDDEPYQGNSGDWKKLFNEVKEKPSTPTINKKQKK
PEKDKCPQ----HID-------TIQGNSSCAPRCDV---DV--YFRQGDKDFAQMWMIVWASLCCLSTTITVLTFAIDSTRFKYPERPIIFLSMCYAIYS
IAYIIRAVTGPVISCDQARDG-----IQEGLESTWCIIVFLILYFFGMASSIWWVILTVTWFLAAARKWGQEAIDALSSYFHLAAWAIPAIKTIIILTMR
-VDGDELTGLCYVGNQDIGALTGFVLSPL-VYLFIGSVFLLSGFAALLRIRNNLKHDG-NIRKLEKLMAKIGIFSVLYTVPATCVIGCYFYERINY-NWR
QQAM-RPC--------ASHLEYSIPTVEVYMLKIFMSLVVGITSGMWIWSSKTAASWKQFFSNR----------
>tr|A0A0L8IGT0|A0A0L8IGT0_OCTBM Uncharacterized protein OS=Octopus bimaculoides GN=OCBIM_22037630mg PE=4 SV=1
-------------------------------------------RQHERCERITIPMCLNMRYNMTKMPNLLGQINQKDAAIQVHEFLPLVELGCSKLLRF
FLCSFYAPMCTEMVLVVSACRSMCLEVKSKCEPVLKNLMFTWPASLDCQQLPEHSNKHLCMEAPNVTDEPDMQPETINAEWWNIVQSFKDKGHNRDIGST
HTLCPDRF----VY-VDK----HGGHNYSCAPRCNI---D--VYFKQEDKRFAKIWLLVWATFCCISTTITVLTFAIDTSRFKYPERPIIFLSMCYAIYS
GAYMIRGITGPSISCDRLR---D---IQEGLE-TWCIIVFLILYYFGMASAIWWVILTLTWFLAAGRKWVQEAIESLSSYFHVAAWAIPAVKTIIILTMR
-VDGDELTGLCFVGNQDIVALTGFVITPL-IYLIIGTIFIFAGFFAMFKIRRNLKQDG-NIRKLEKLMAKIGIFSVLYTLPATCVIGCYFYERINF-NWK
TE--RRRCRSN----GEKSLSQSIPTIEVYMLKIFMSLIVGITSGMWVWSYKTVNSWKNFFSSR----------
>tr|R7ULU7|R7ULU7_CAPTE Uncharacterized protein OS=Capitella teleta GN=CAPTEDRAFT_176783 PE=4 SV=1
-------------------------------------------ITYGRCERITIPMCRDMRYNMTRMPNLIGHTSQKDAEQQIREFIPLVQIRCSKLVKF
FLCSLYAPMCTEQTLVVPACRSMCLEVKSKCEPIMTRFSFNWPSVLDCSKLPLKSDTNLCMDAPNMDEPELASDDAYLSGGVTPNAECSTP-SGMVQSGK
GPTCSERF----VY-VEK-----PGNNQTCSPRCNM---D--VYFRQEDKKFAEVWMLVWASLCLASTLVTVLTFLIDSTRFKYPERPIIFLSMCYTIYS
LAYLARAFLGPTIACDSNK---H---IQEGLE-TWCILVFLVLYFFGMASSIWWVVLTLTWYLAAGRKWGREAIQSLSSYFHLAAWAVPAIKTIVILTMR
-VDGDELTGLCYVGNQDQSALVGFVLVPL-AYLFIGTAFILAGFLAMFRIRHNLKQDG-NIRKLEQLMAKLGVFSVLYTVPATCVIGCHLYEHMNS-HWR
QQ--QKDCRIGP-KAGQLSLDASIPTVEVYMLKIFMSMVVGITSGMWVWSSKSLSSWNNFICGT----------
>tr|K1QB03|K1QB03_CRAGI Frizzled-10-A OS=Crassostrea gigas GN=CGI_10016515 PE=4 SV=1
-------------------------------------------HRHARCERITIPMCMDMRYNLTRMPNLIGHTNQKDAAIQVHEFTPLVQFGCSRLLRF
FLCSQFAPMCTEMTLIIPVCRSMCLEVKSKCAPILTKFSFEWPPMLDCSKLPQKDDNNLCMEAPNMTDDPQITDGAGIFDKEKDPEDWININKIFPKVPM
EKTCPDRF----VR-VDT-----GADNSTCAARCNV---D--VMFRQADKKFAEYWTVGWASLCCLSTVFTVLTFVIDTSRFKYPERPIIFLSMCYAIYS
FAFFIRAITGPAISCDRTI---D---IQEGLD-TWCIIVFLIMYFFGMASQLWWVILTLTWFLAAGRKWGQEAIETLSSYFHMAAWAIPSIKTIIILTMR
-VDGDELTGLCYVGNQDIKALTGFVLAPL-VYLLLGTLFILSGFVSLFRIRNNLKQDG-NIRKLEKLMAKIGIFSVLYTVPATCVIGCYFYERVNY-VWL
TA--LLSCGRT----GGTGLTQSIPQVEVYMLKIFMSLVVGITSGMWVWSSKTLNSWKTFFSNR----------
>tr|A0A0P4WD34|A0A0P4WD34_9EUCA Uncharacterized protein OS=Scylla olivacea PE=4 SV=1
-------------------------------------------PSPRRCERIIIPMCQEIPYNNTKMPNLLGQFSQGEAAIKVHEYMPLVDIGCSQHLRF
FLCSLYAPMCTPV--GIPSCRSICLEVRKNCLPVLRKFNYSWPAALDCNRLPN--PETLCMEPDSNSSSTAPSSPLPDQRNPPPSQD---------LAEP
SLCPPRQT--WV----------GAGGVGGCAPVCGK---D--VLFRREDKHFAEVWLLVWAALCFASTLFTVLTYCLEPARFRYPEHPIICLSLCYLLYC
LAYLLRLVAPIVLSCERS--P-----TVQGLL-PGCIITFILQYYFSLASGIWWLVLTFTWFLSAGKKWSSEALLAYASYFHATAWGLPAVATILVLSLK
-VDGDELVGVCYVGLSRRWAHLAFVIVPL-TLLALGTMFIALGFVALFRIRRAIKSEATNITKLEKLMVRIGIFSVLYTVPAVCVIACNVYEYVGR-HWE
KVA-VQAALRCYQRGTGTTLEQSIPSVEIFMLKIFMSLVVGITSGMWIWSSKTVMLWQKFFRGM----------
>tr|V9KHZ2|V9KHZ2_CALMI Frizzled-like 8a (Fragment) OS=Callorhinchus milii PE=2 SV=1
----------------------------------------------------TVPMCKGIGYNLTYMPNRFNHDNQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPQQSNETLCMDYNRTDLSTAAP-GRARPSDKPPSGAGKANCERGCQCRA
PMVQVSSE----HPLYNRG------QMANCALPCHN------PYFSQDERSFTAFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLSACYLFVS
TGYIVRLVAGHSVACSQQR-------YYET--TALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIANYSQYFHLAAWLVPSIKSIAVLALS
-VDGDPVAGICYVGNQNLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRNVIKQG-TKTDKLEKLMIRIGIFTVLYTVPATIVVACYFYEQHNR-SWE
MTH-NCS-CLT-----E----ARRPDYAVFMLKYFMCLLVGITSGVWIWSGKTLESWRAFCTR-----------
>tr|B7ZQV9|B7ZQV9_XENLA Frizzled-8 OS=Xenopus laevis GN=xfz8 PE=2 SV=1
-------------------------------------------AKELSCQEITVPLCKDIGYNYTYMPNQFNHDTQDEAGMEVHQFWPLVVIHCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPEQGNDTLCMDYNRTEQTTAAP-SHPEPPKPPARSVPKSRCESGCQCRA
PMVQVSNE----HPLYNRG------QTPNCAMPCHN------PFFSPEERTFTDFWIGLWSVLCFASTFATVSTFLIDMERFKYPERPIIFLSACYLLVS
TGYLIRLIAGHKVACSRGEL------HYET--TALCTLVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSIKSIAVLALS
-VDGDPVAGICFVGNQNLDNLRGFVLAPL-IYLFIGSMFLLAGFVSLFRIRSVIKQG-TKTDKLEKLMIRIGIFSVLYTVPATIVVACFFYEQHNR-GWE
VAH-NCNSCQS-----A---QPRRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRAFCTR-----------
>tr|G1K937|G1K937_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=FZD8 PE=4 SV=1
-------------------------------------------SASLSCQEITVPLCKGIGYNYTSMPNQFNHDTQDEAGLEVHQFWPLVEIQCSSDLRF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPAQGDDTLCMDYNRSEAATTPP-PAPPPQAPPPPPPRAPPPGAPPLCKP
DCGARGDA----RALLPCG------RIPNFPWPA-R------ILLHPNERAFTAFWIGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVS
LGYLVRLVAGHKVACSAGA-------RYES--TALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQYFHLAAWLLPSVKSIAVLALS
-VDGDPVAGICYVGNQSLENLRGFVLAPL-IYLAIGSMFLLAGFVSLFRIRSVIKQQGTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNR-RWE
ATH-NCPCLRD-----P--DQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTR-----------
>tr|A0A077SMV2|A0A077SMV2_9METZ Frizzled D SciFzdD OS=Sycon ciliatum GN=FzdD PE=2 SV=1
-------------------------------------------FKNERCEPLQVATCRDVGYNSTLLPNRLGHNTQKDAGLIANQYFPLIEVNCYDKLQF
FVCAVYLPMCLPD--YLPPCRSICLQAKSKCEPLMQQFGFHWPEDLRCDKFPESSTDQLCAGNDTLPPRPTSRPGLNLIGGTARP------------IGG
IATTDLPA---------T----RPPYNKK-RIPCGQ---Q--HFYRKEDRDTSRYWVGVWATLCFLSSVLVVATYCIDRERFNYPERPVIYLAGCYVMFS
FGYLVSLMVGD-IACADG--------VQPDEA-AGCIIVAFLLYFSWMAAALWWVTLAFTWFLAASLKWAPEGIGKHFFKYHVFSWGVAIVQTVLLMALK
-VDADELTGACFVGYFDDKSLAGFVIGPL-VYLIIGALLFLYGFMSLVNIRSVIRQSAHRTDKLEKLMVRVAVFSILYAIPTAVVLGCLFVEHSEK-SWK
YPM-D------GSCNAGYNCDGVPAKPALFMLRLFMVLIVGLASGIWIWSTKTLESWGRRFGRS----------
>tr|A0A0P7URH7|A0A0P7URH7_9TELE Frizzled-4-like OS=Scleropages formosus GN=Z043_108755 PE=4 SV=1
--------------------------------------------DEATCDPIRISMCQDLGYNETRMPNLVGNVLQADAELQLTTFTPLIQYGCSSQLRF
FLCSVYVPMCTDK-EPIGPCGSMCLSVKRKCLPVLTDFGFVWPELLNCSLFPPQ-NNHMCMEGPGDEDGPYHAIRTLQPME-------------------
--EECHAL----QYA-------WVKRSHACVLQCGY---DS-GLYRRQAKVFTDVWMAVWAVLCFVSTAFTVLTFLVDSSRFSYPERPIIFLSMCYNIYS
IAFVVRLTVGRRISCDLEEAA-----VQEGLKNTGCAIVFLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMR
-VDADDLTGLCYVGNQHIDALTGFVVAPL-TYLAIGTLFIAAGLVALFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYMVPAGCVIACYLYEISNW----
----------------DFKQSARDAYAAVEMLRIFMSLLVGITSGMWIWSAKTLHTWQKCSSRL----------
>tr|W5K860|W5K860_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
--------------------------------------------EDARCEPIRMAMCLDLGYNQTRMPNLVGNVLQADAELQLQTFTPLIQYGCSSQLKF
FLCAVYAPMCTEK-VTIGPCGSMCLAVKRKCLPVLQEFGFVWPELLNCSLFPPT-NNHMCMEGPAEDDLF-HPNKPVAPHE-------------------
--EECVTM----QYA-------WAKRSGSCVLQCGY---ES-GLYRRQAKMFTDVWMAVWAVLCFISTSFTVLTFLLDSARFSYPERPIMFLSMCYNVYS
VAFLVRLTAGRRISCDLDEAA-----AQEGLKNTGCAVVFLLAYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMR
-VDADDLTGLCYVGNQNLDALTGFVVAPL-TYLVIGTLFIAAGLVALFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYTVPATCVIACYFYQISNW----
----------------DFHQTARDSYMAAEMLRIFMSLLVGITCGMWVWSAKTLHTWQRCSLRL----------
>tr|A0A0P7U393|A0A0P7U393_9TELE Frizzled-5-like OS=Scleropages formosus GN=Z043_117087 PE=4 SV=1
-------------------------------------------SRDITCEPITVPMCKGIGYNLTHMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLF
FLCSMYTPICLPD-KPLPPCRSVCERAKRGCSPLMSQYGFEWPERMSCERLPVLGDERLCMDQNSSETTTLSP-LFQKPTPKGLPRRKVAACRRECYCRE
PLVPIKAE----HPLYNRG------PLANCALPCHQ------PYFSADERAFTAFWIGLWSVLCFISTLTTVATFLIDMERFKYPERPIIFLAACYLFVS
LGYIVRLVAGHRVACGA---------LYDT--TALCTLVFLLIYFFGMASSIC-------------------------------------VKSIAVLALS
-VDGDPVAGICYVGNQSLENLRGFVLAPL-VYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYR-VWE
EAL-GCSCAAE-----R-----LGPDYPVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFVTRC----------
>tr|F7F2K2|F7F2K2_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=FZD4 PE=4 SV=1
--------------------------------------------EAKRSEPIKFKMCQNLGYDVTKMPNLVGHELQADAELQLTTFTPLIQYGCSGQLQF
FLCSVYVPMCTEK-IPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQ-NNHMCMEGPGDEDVPLP-HKTSLVPG-------------------
--EECHSM----QYV-------WVKRSLSCVLKCGY---DA-GLHSRSAKEFTDVWMAVWASLCFVSTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYS
VAYLVRLTVGRRISCDFEEAA-----IQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLTAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVVLIMR
-VDADELTGLCYVGGQNLDALTGFVVAPL-TYLVVGTLFIAAGLGALFKIRSNLQKDG-QTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNW----
----------------LFRSSADEAGVAVETLKMFMSLLVGITSGMWIWSAKTLHAWQKCSNRL----------
>tr|H2ZX74|H2ZX74_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD4 PE=4 SV=1
--------------------------------------------EERLCDPIRISMCQNLGYNVTKMPNLVGHELQSDAELQLTTFTPLIQYGCSSQLQF
FLCSVYVPMCTEK-IPIGPCGSMCLSVKRKCEPVLKEFGFIWPESLNCSNFPPQ-NNNMCMEGPGDDDVHYHSTKTDLQPG-------------------
--EDCHSV----QYI-------WVKRSLNCVLKCGY---DA-GLYSRSAKEFTDIWMAVWASFCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYS
IAYIVRLTVGRRISCDFEEAE-----IQEGLKNTGCAIVFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMR
-VDADELTGLCYVGNQNTDALTGFVVAPL-TYLVIGTLFIAAGLVALFKIRSNLQKDG-KTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNW----
----------------IFKSSADDSSMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNKL----------
>tr|C3XUQ1|C3XUQ1_BRAFL Putative uncharacterized protein OS=Branchiostoma floridae GN=BRAFLDRAFT_269437 PE=4 SV=1
-------------------------------------------SGQYSCDPIRIDMCNNLGYNVTRMPNLVGHDMQQDAELQLQTFTPLIQYGCSSQLQF
FLCSVYVPMCTEK-IPIGPCQSMCLSVKRRCEPVLKEFGFPWPPTLNCSKFPLQ-NNTMCMEGPGDDEVNLADGSAGNERRGGGPTT--------PDGNG
NSLHAESC----SYM-------YVKRTDSCALKCGV---EY-GNFTPEEKRFADIWMAVWAGLCFLSTMFTVLTFLIDTARFRYPERPIIFLSMCYNIYS
IAYIVRLVVGRAISCDSEDG------IQQGLENTGCAIVFLFLYFFGMASSIWWVILTLTWFLSAGLKWGHEAIEMHSSYFHLATWSIPAIKTIVIFVMK
-VDADELTGLCFVGNQNLDALTGFVVAPL-TYLVVGTSFLLAGFVSLFRIRNFMKNDG-KTDKLERLMVKIGVFSVLYTVPATCVIACYFYEHSNR----
----------------LWRYSSAKPNIELYMLKIFMSLVVGITSSMWIWSAKTVSSWANCTRRL----------
>tr|W4XX60|W4XX60_STRPU Uncharacterized protein OS=Strongylocentrotus purpuratus GN=Sp-Frizz4 PE=4 SV=1
-------------------------------------------PQTVMCEPITIKLCQGVGYNMTRMPNLVGHELQQDAELQLQTFTPLIQYGCSPFLRF
FLCSVYAPYCTDK-VPISVCRPLCERVRASCNPVLSKFGFKWAEALNCSQFLERSDNDICMGPPPGEGDVNGIGNPDGDIVTAIVPQEP-----GEPDCQ
HHREPQKW----HY-VKR--------YEKCALRCDA---D--FLFSQSEKQFTEIWMAIWAGLCFLTTAMTVLTFAIDTVRFRYPERPIIFLSICYNIFS
IAYIVRLIAGRVIACDDDG-------IQEGLE-TGCAVTFLILYFFGMASSIWWVILAFTWFLAAGLKWGHEAIQMNSSYFHVAAWGIPFVKTVIILVMR
-VDADELTGMCFVGNSSLEALTGFVIAPL-TYLAVGTLFLLGGFISLFKIRSVMKNDG-KTDKLERLMVKIGLFSVLYTVPATIVVACFFYEHSNR-VWM
D-------------------GEATPNIEVFMLKIFMSLVVGITSGMWIMSAKTMRSWRRFLERM----------
>tr|D1LX20|D1LX20_SACKO Frizzled 5/8-like protein receptor OS=Saccoglossus kowalevskii PE=2 SV=1
-------------------------------------------GRDMTCEEITIPMCRGIGYNMTYMPNQFNHDSQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYAPICVMN-QPLPACRSVCERAKAGCAPLMRQYGFAWPERMRCDDLPEFGDTTICMDFNSSEATVTPTPASAGVTERPRPTEHC----DACTCES
PMVHISEE----SSYYNKG------GVENCGIPCEG------AFFTADEKTFASFWIGLWSILCFISTSMTVSTFFIDMQRFKYPERPIIFLSACYLLVS
VGFIVRLIVGHAVACMD---------RYET--TAVCTVVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSVKSIAVLAMS
-VDGDPITGICYVGNQSLDNLRGFVLAPL-VYLLIGTSFLLAGFVSLFRIRNVIKQGGTKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQHFR-SWE
RSY-NCPCERA----------KTNPDYSVFMLKYFMCLVVGITSGFWIWSGKTLESWKKFYHRL----------
>tr|F2X0X4|F2X0X4_9BILA Frizzled receptor 5/8 OS=Ptychodera flava GN=fz5/8 PE=2 SV=1
-------------------------------------------VREMVCEEITIPMCRGIGYNMTYMPNQFNHDSQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYAPICVSN-QPLPACRSVCERAKAGCAPLMRQYGFAWPERMRCDDLPEYGDTKLCMDFNSSEATVTPTPSVIGTQRPRPEEGCS-----SCTCKD
PMVPLTEE----SSYYGKG------GAENCAMPCNG------AYFSPDEKTFASFWIGLWCILCFISTSMTVSTFFIDMQRFKYPERPIIFLSGCYLLVS
VGYIVRLIVGHAVSCTD---------RYET--TAVCTVVFLLIYFFGMASSIWWVILSFTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSIKSIAVLAMS
-VDGDPITGICYVGNQNLGNLRGFVLAPL-VYLLIGTSFLLAGFVSLFRIRNVIKQGGTKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQHFR-SWE
QSH-NCPCIE-----------KTTPDYSVFMLKYFMCLVVGITSGFWIWSGKTLESWKKFYNRL----------
>tr|A7S003|A7S003_NEMVE Predicted protein OS=Nematostella vectensis GN=v1g183962 PE=4 SV=1
-------------------------------------------TKEMKCEEITIPMCRGIGYNLTYMPNMFNHDTQAEAALEVHQFWPLVEIQCSPDLRF
FLCSMYAPLCEKH-KDLPPCRSVCERARTGCAPLMRKYGFSWPERMKCENFPELGDNTLCMGRNSSGESTPKPSQSPQPAPSPDTAAIS-----ANCCSC
RPPFVSIA----PT-RAI----SVGGVPQCAMACNR--TYF----THDQDSFASFWIGLWAILCFISTLVTTLTFLVDMHRFKYPERPIIFLSGCYLMVS
VGYIIRLIAGHQIACDSNG-------YD-TS--ASCTIVFLLVYFFGMASSVWWVILAFTWFLSAGMKWSSEAITNYSQYFHAVAWLVPAIQAIAVLAMS
-IDGDPVSGICYVGNHNLQSLVVFVIVPL-VYLVFGTSFLMAGFYSLVRIRKLLRQH-TKTDKLEKLMIRIGVFSVLYTVPATIVVACYYYELVNR-TWE
RT--CSGCGV----------TRVKPDHSVFIIKYFMALVVGITSGFWIWSGKTIESWRNFCARL----------
>tr|V4AZ33|V4AZ33_LOTGI Uncharacterized protein (Fragment) OS=Lottia gigantea GN=LOTGIDRAFT_200873 PE=4 SV=1
-------------------------------------------EEPRKCLEISIPMCKGIGYNYTYMPNQFNHETQEEAGLEVHQFWPLVEIQCSPDLLF
FLCSIYAPICMTN-KHLPACRSVCERAKSGCAPLMRQYGFAWPERMNCESLPEYGDDHLCMDMNTTDPQTPAP-PTGGFTGKPLPKRPITQKQCSCKCES
PLVTVKEG----PNYYNRG------GIANCAVNCYS------PYFGKNEKTFATFWIGLWSILCCISTAMTVSTFFVDMQRFKYPERPIIFLSACYFMVS
VGYIIRLIVGHKVACDGD--------RYET--TALCTVVFLLVYFFGMASSIWWVILSFTWFLAAGLKWGQEAIASYSQYFHLAAWLIPSVKSIAVLAMS
-VDGDPIAGICYVGNQNIENMRGFVLAPL-VYLIIGTSFLLAGFVSLFRIRNVIKQQGGKTDKLERLMIRIGVFSVLYTVPATIVIACHFYEQYLK-KWE
TSH-NCLSCQA----------QWRPDYSVFMLKYFMCLVVGITSGFWIWTGKTVESWR----------------
>tr|R7TP46|R7TP46_CAPTE Uncharacterized protein OS=Capitella teleta GN=CAPTEDRAFT_140195 PE=4 SV=1
-------------------------------------------DGPRQCQEITIPMCRGIGYNLTHMPNQFNHDTQEEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYAPICMTN-KPLPACRSVCERAKSGCAPLMRQYGFAWPERMRCDSLPEYGDDRLCMDFNTTDRPRPRP-SAPPKPPKKTCSC---------SCAE
SLVSIGNK----SIYYNKG------GQENCAMSCDG------AYFSEDEQTFAQFWIGLWSVLCCLSTAMTVFTFLVDMQRFQYPERPIIFLGGCYTMVS
IGYIIRLALGHAVACDTYG-------RYET--TAVCTVVFLLIYFFGMASSIWWVVLSFTWFLSAGLKWGQEAIAGYSQYFHVAAWLVPSIKSIAILATS
-VDGDPVAGVCYVGHQNITKLRGFVIAPL-VYLLLGMSFLLAGFVSLFRIRNVIKQQGGKTDKLEKLMIRIGIFSVLYTVPATIVIACYFYEQYFR-HWE
RSL-TCPCERS----------HSRPDYSVFMLKYFMLLVVGITSGFWIWSGKTIDSWRRFYGRL----------
>tr|A0A0L8HAJ2|A0A0L8HAJ2_OCTBM Uncharacterized protein OS=Octopus bimaculoides GN=OCBIM_22018859mg PE=4 SV=1
-------------------------------------------------------MCRDIGYNMTYMPNQFNQETQEEAGLEVHQFWPLVKIQCSPDLRF
FLCSLYLPICMEN-KPLPPCRSVCERAKAGCAPVMLVYSFVWPEHMNCDELPEFGSKPLCMDMNVTDRPSPPT-KPHYLLPTDRSYNPFGEKKCSCECKP
PLVQPDNR----AYYYNRG------KIKKCAINCYG------PYFGRNERTFANFWIGLWSILCCISTATTISTFLIDMQRFRYPERPIIFLSACYFMVS
IGYIMRLIVGHKVACDGN--------RYST--TAMCTVVFLLIYFFGMASSIWWVILSFTWFLAAGLKWAEEAIASYSQYFHLAAWLIPSVKSIAVLAMS
-VDGDSVGGICYVGNQNLENLRGFVLAPL-VYLVLGTSFLFGGFVSLFRIRNAIKRQGAKTEKLEKLMIRIGVFSFLYTVPATIVIAIYFYEQHMR-VWE
TDF-TCSCGGY------------KPDFSVFMLKYFMCLVVGITSGFWIWTGKTLDSWKRFYGKI----------
>tr|A0A068CNH2|A0A068CNH2_HOFMI Frizzled-11 OS=Hofstenia miamia PE=2 SV=1
-------------------------------------------DERGKCQPITVPMCLNLGYNMTTMPNPFGQLTQEEAGLEVHQFWPLVEINCASELKF
FLCSMYVPFCTED-NEIKPCRPICLRTRKGCEPIMKEYGFEWPERMNCDHFPPRQTEVVCMDNPNVEKDAEKNEEKPTKPKPTDVPSKNGFDLSLCGCKC
QPPFHAVP-------MNI----STGIVNHCASPCRS--PYF----SVEERKFATLWVSVWSIVCLISTTIISLTFLIDMQRFTYPERPIVFLSACYLFIS
AGFVISLIFGHRVACDSN--------YSIDS--GPCLIVFILIYYFSMASSIWWVILSMTWFLAAGMKWGSEAIANYSWWFHFVGWVLPCIQTVIVLFTK
-VDGDALTGICYIGNQDRWNLFMFVITPL-VYLMIGTVFLLGGFISLFRIRHVIKQ--TKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEFRYR-LWE
VT--CNESQC----------LQIVPDYTVFMLKYFMSLIVGITSGFWIWTGKTLHSWQSFFSRI----------
>tr|Q2WC00|Q2WC00_PARLI Putative frizzled receptor OS=Paracentrotus lividus GN=fz5/8 PE=2 SV=1
-------------------------------------------IRDAKCEPITVPMCRDIGYNMTYMPNHFNHDSQEEAGLEVHQFYPLVEIQCSPDLKF
FLCSMYTPICLAD-KPLMACRSVCERAKAGCAPLMRQYGFAWPDRMQCENLPEFGDDNLCMDSNHTNAGTSAPTNPPMTRPGGRRPRPRPTDKPCDCSCN
EPLISIPE----HPYYNRG------GISNCATPCKS------AFFSEDEHTFATFWIGLWSILCFVSTLMTVATFLIDCGRFKYPERPIIFLSACYFMVS
LGFIIRLVVGHQVACSGD--------RVGS--TALCTIVFLLIYFFSMASSIWWVILAFTWFLAAGMKWGSEAISSYSQYFHLAAWLLPSIQSIAVLALS
-VDGDPIAGICYVGNHDLAKLRGFVLAPL-MYLIIGCSFLLAGFVSLFRIRNVIKQGGRKTDKLEKLMIRIGIFSVLYTVPATMVVAIYIYEQHSR-DWE
RGV-TCPCQAD----------LPKPEYSVFMLKYFMCLVVGITSGVWIWTGKTLSSWRGFVNRL----------
>tr|F1KY14|F1KY14_ASCSU Frizzled-5 OS=Ascaris suum PE=2 SV=1
-------------------------------------------FNTQKCEPITIPLCKGIGYNMTRYPNSYGHEKQEEAGLEVHQFYPLVEVGCYNHLKF
FLCAMYTPICQEN--MVMPCMELCLEAKKRCSPLMQQYGFKWPATLSCEQLPRI-SQTT---------------GNICAAPPDTPDPAIFECKCRCVRPF
HTVSDPNSM---NV-------------SGCAYPCHSSRDQ----------KFLTAWMAIWSGTCFILSAFTVLTFLIEMERFQYPERPIFLLAFCQMMVS
IGFIIRVFYGHYVACDSWTIRS-------DQQ-NSCQLVFILVYFFGMAGSVWWVILSLTWVLAAASKWSSEAIASYANYFHLLAWALPALQTITVILFG
-VDGDPLSGICYVGNTNVGHLRTFVFAPL-VYFVAGVCFLAVGFFNLWRIRSLMQKHHDNTSKMTQLMSKIGIFSVLYIVPAVFVLMVLAYEQHYR-LWE
HAQ-LCSCATPQ----P------DTSTLLTLIKSASMLVVGWTSGVWIISGKTIQSWKRV--------------
>tr|A0A0N4U0P0|A0A0N4U0P0_DRAME Uncharacterized protein OS=Dracunculus medinensis PE=4 SV=1
-------------------------------------------NGFQNCEQITIPLCKGIGYNMTRYPNSYGHEKQEEAGLEVHQFYPLVEVGCYKHLKF
FLCAMYTPICQHN--MVMPCMEVCLEAKKRCSPLMHQYGFKWPLALNCEQLPRM-SQIT---------------GNICAAPPDTPDPAVFDCKCRCIRPF
LQIADSRSY---NV-------------SGCSYPCHKRLIQ--FSLFFNMVNFTAIWDIPMSGTCFLLSAFTVLTFLIETDRFQYPERPIFLLAFCQMMVS
LGFMIRVVYGHYVACDSRMVRH-------DQQ-NSCQLVFLLIYFFGMAGSVWWVILSLTWVLAAANKWSSEAIASCANYFHFAAWILPAIQTVAVIVFG
-VDGDSMSGICYVGNTNIDHLRIFVFLPL-IYFVAGVCFLCIGFFNLWRIRSLMQKHHNNTSKMTQLMSKIGIFSVLYIVPAVFVLMILIYEQQYR-QWE
RSQ-LCNS---------------ETFIFLTLIKSASMLVIGWTSGVWIISKKTLQSWKRT--------------
>tr|T1J7J7|T1J7J7_STRMM Uncharacterized protein OS=Strigamia maritima PE=4 SV=1
-------------------------------------------ALPPSCDPIRIEMCRGLGYNVTSMPNLVGHELQQDAEMQLQTFSPLVQYGCSSQLRL
FLCSVYVPMCTDK--PIGPCRSLCEVVRSRCQPVLQEFGFPWPSALNCSQFPPENNHHMCMVGPGEESPERDPFFPPYGGRNRPYGGRQRNKPPDSLLPI
QDPCLQYK--NGEM-Y-V----YVNRTERCVPMCHA---N--VLFRSEDKQFAQVWVAVWAILCYVTTFITVITFLIDSSRFKFPEKPIIFIAITYNLYS
VGHLVRFVAGRDIACLAA--DV----VQEGLS-TNCVIVFLLLYYFGMASCVWWVILSLTWYLTQGLNWSHESIERHSSVFHVFAWGLPAAQTIAALVMR
-VDADELTATCYVGQQSTLSLFIFVLVPQ-VYLIFGAGFILVGFLRT---RY-Q----SISSKAEVFLFRVGIFSFLYMIPAVCVFGTNIYEYMNR-NWL
SVG-TM----------S------QPNLEVFMLKIFMTLVLGITSGMWIWSKKTVDTWQRLGNRI----------
>tr|V5H6Z3|V5H6Z3_IXORI Putative smoothened OS=Ixodes ricinus PE=2 SV=1
-------------------------------------------DSGRMCEPIRIEMCKDIGYNVTGMPNLVGHELQQDAQLQLQTFKPLVQYGCASQLKF
FLCSVYVPMCTEK--PIGPCRPLCESVRTRCQPVLQEFGFPWPAALNCSKFPPQNNRHMCMDGPAPEESERFR-GGLRPKPPRLSRKPLPP-PGADRARL
RGLCDAYH--HGDR-YFF----FINRTERCAHLCDR---D--ILFTQENKRFAEIWTSVWACLCFLSTLFTLGTFFVDSRRFHYPERGIIYMSGCYNVYC
VAYFVRLLLGRSVSCHLD--SQ----IQEGVD-INCTVVFMLLYYFGMASATWWVVLTVTWFLSAGLRWSHERVQKHMTAFHFFAWVLPAVQTIVILVMR
-VDADELTGTCFVGNQNRHALLGFVVLPS-VYLLVGAIFLAWGIVTMMRSRDS-----PKADKLEIIMIRVGIFAVLYMVPAACVLASYIYEYSYR-EWL
AAG-SA----------F------RPNLEVFTLRIFMSLVVGITTGLWTWSSRVPLAACRRP--M----------
>tr|A0A0K2UB31|A0A0K2UB31_LEPSM Frizzled5like [Oreochromis niloticus] OS=Lepeophtheirus salmonis PE=4 SV=1
-------------------------------------------QEMYQCVPIKVDFCSGMRYNLTRMPNKFNHQTQEEAELEVIQFRPLVDIQCSPDIRF
FLCGLYTPICLPN--PVPVCRSVCERVKRSCFPIMKQYGFDWPSKMECSLLPE--GDEICMDPWDVTSNEQGQ-GTSSTNPPPHVNENG----CSCPNKM
IIPGSKAF----K-------------VENCHSTCRSPEM-------SSA-YSL-EMLSTLSIVCMIASCMTSFTFVVDTQRFNYPSRPILYISYCYIMVA
LGNVLRLSVGHRTSCSKTEGEI----LDFNQE-TTCLSVFILTYYFGTAANLWWIALTYSWFLSSGLKWAPEAISNISYWFHIISWTIPAVKTLIILILN
-VDGDPISGICYVGSQNRYNLIGFVIFPS-IYIFISLYFLMRAIISLFKIHGSLPREQ--VGSFEKLLIRISIFSALYLWPTITVWSCWVYELWNA-IWE
DNI-ACEKSSL------------KPNLYILFLKYAMMLMPGISSASWICSEKTIEISWQKIFMF----------
>tr|H2P8F5|H2P8F5_PONAB Uncharacterized protein OS=Pongo abelii GN=FZD5 PE=4 SV=1
-------------------------------------------SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSMYTPICLPD-KPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGREVLCMDYNRTEATTAPP-RPFPAKPTLPGPPGAPAGPSVCKCRE
PFVPILKE----HPLYNKG------QVPNCAVPCYQ------PSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVS
LGFLVRLVVGHSVACSREH-------HYET--TALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALS
-VDGDPVAGICYVGNQNLNSLRGFVLGPL-LYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYR-SWE
AAL-TCACPGP-----G--QPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRC----------
>tr|Q4SZ16|Q4SZ16_TETNG Chromosome 2 SCAF11863, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis GN=GSTENG00010060001 PE=4 SV=1
-------------------------------------------SKDLVCEPITVPMCKGIGYNLTYMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLF
FLCSMYTPICLPD-KPLPPCRSVCERAKQGCSPLMSQYGFEWPERMSCEKLPQLGDEVLCMDQNGTESTTLAS-TFPKPTPKVQSRTPSPACERECRCRT
FLVPIRRE----LPPYQHGPGPGPGPGPSCAQPCHQ------PFFSAEERAFTGLWIGLWSVLCFVSTLTTVATFLIDMERFQYPERPIIFLAACYLFVS
LGYIVRLVAGHQVACGAGG-------LYDA--TALCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGSEAIAGYAQYFHLAAWLVPSLKTIIILAMS
-VDADPVAGICYVGNQNLESLRGFVLAPL-VYLFTGSFFLLAGFVSLFRIRSIIKQGGTKTDKLERLMIRIGLFTVLYTVPATVVVACLVYEQHYR-GWE
EAL-GCSCLTE-----L---LGLGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRVVARC----------
>tr|A0A0F8C7W7|A0A0F8C7W7_LARCR Frizzled-5 OS=Larimichthys crocea GN=EH28_03228 PE=4 SV=1
-------------------------------------------SKDLVCEPITVPMCRGIGYNLTYMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLF
FLCSMYTPICLPD-KPLPPCRSVCERAKRGCSPLMSQYGFEWPERMSCEQLPELGDDTLCMDQNSSETTTLAP-PFPKPTPKGRTRPPNPPCDRECRCRE
PLVPIKRE----HTLYSQG------PVPHCAQPCHQ------PYFSADERAFTGFWVGLWSVLCFISTMTTVATFLIDMERFKYPERPIIFLAACYLFVS
LGYIIRLVAGHRVACGASN-------LYDT--TALCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGMKWGSEAIAGYSQYFHLAAWLIPSVKTIVVLALS
-VDGDPVAGICYVGNQSLENLRGFVLAPL-VYLFTGSLFLLAGFVSLFRIRSIIKQGGTKTDKLERLMIRIGLFTVLYTVPATIVVACLVYEQYYR-GWE
RAL-ACSCPSE-----R---SGVGPDYAIFMLKYFMCLVVGITSGVWIWSGKTLESWRRFVARC----------
>tr|M4B0Z5|M4B0Z5_XIPMA Uncharacterized protein OS=Xiphophorus maculatus GN=FZD8 (2 of 2) PE=4 SV=1
-------------------------------------------AKELQCQEISVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIKCSPDLRF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMSQYGFPWPDRMRCDLLPEQGNDTLCMDYNRSQTTTASP-VLAKPTNRPLKPYNKKKCETGCFCRA
PMVPVTSE----HPLHNRG------QITNCAMPCHN------PYFTQEERTFTAFWIGLWSVLCFISTFATVATFLIDMERFKYPERPIIFLSACYMFVS
VGYIVRLIAGHEVACSRES-------HYET--TALCTIVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSLKSITVLALS
-VDGDSVAGICYVGNQNLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRSVIKQG-TKTDKLERLMIRIGVFTVLYTVPATVIVACYFYEQHNR-TWE
ITH-NCT-CVT-----S----RQRPDYAVFMLKYFMCLLVGITSGAWIWSGKTLESWRTFCTR-----------
>tr|A0A060YPM9|A0A060YPM9_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00044597001 PE=4 SV=1
-------------------------------------------AKELQCQEISVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIKCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGNDTLCMDYNRST-TTVSP-VVAKPTHRPVKPVNPRKPCEPQCHCR
APMVPVSN----NPLYNRG------QILNCAMPCHN------PYFSQDERTFTAFWIGLWSVLCFISTFATVATFLIDMDRFKYPERPIIFLSACYMFVS
VGYIVRLIAGHQVACNMEH-------HYET--TALCTIVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSMKSIAVLALS
-VDGDPVAGICYVGNQNLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRSVIKQG-TKTDKLERLMIRIGIFTVLYTVPATIIVACYFYEQHNR-TWE
ITH-NCS-CLS-----E----MQKPDYAVFMLKYLMCLLVGITSGAWVWSGKTLESWRTFCTR-----------
>tr|W5U7U1|W5U7U1_ICTPU Frizzled-8 OS=Ictalurus punctatus GN=fzd8 PE=2 SV=1
-------------------------------------------AKELSCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSADLRF
FLCSMYTPICLED-KPLPPCRSVCERARAGCAPLMRQYGFPWPDRMRCELLPVQGNDTLCMDYNRTDATTAAP-VLPKPTSYPGRAHGSGRCEAGCQCRA
PMVRVSSE----HPLYNRG------RTPNCAMPCHN------PFFTPDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVS
VGYIVRLIAGHRVACSREH-------HYET--TALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSMKSIAVLALS
-VDGDPVAGICYVGNQNLDNLRGFVLAPL-IYLCIGAMFLLAGFVSLFRIRSVIKQG-TKTDKLEKLMIRIGVFTVLYTVPAAVIVACYFYEQHNR-RWE
AAH-NCA-CAL-----E--RDAERPDYAVFMLKYFMCLAVGITSGVWVWSGKTVESWRALCARC----------
>tr|A0A087YPY1|A0A087YPY1_POEFO Uncharacterized protein OS=Poecilia formosa PE=4 SV=2
-------------------------------------------AKEITCQEIVVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERARAGCAPLMRQYGFPWPDRMKCDLLPVQGNDTLCMDYNRTDSTTVSP-VLSKPTNHPGKGSSPAKCEPGCKCLE
PMVPVNTD----HPLYNRG------QITNCAMPCHN------PYFTHDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVS
VGYIVRLIAGHKVACNREF-------HYQT--TALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLIPSMKSIAVLALS
-VDGDSVAGICYVGNQNLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRSVIKQG-TKTDKLEKLMIRIGIFTVLYTVPATVIVACYFYEQHNR-SWE
ITH-NCSNCLL-----D----RRSPDYAVFMLKYFMCLLVGITSGVWIWSGKTVDSWRTFCTR-----------
>tr|F7G1W9|F7G1W9_MONDO Uncharacterized protein OS=Monodelphis domestica GN=FZD5 PE=4 SV=2
-------------------------------------------SKALVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRF
FLCSMYTPICLPD-KPLPPCRSVCERAKAGCSPLMRQYGFAWPERMNCDRLPVLGDETLCMDYNRSESTTAPP-RAFPGKPTLAAPRASASECGTCECRE
PFVRIQKE----HPLFNKG------RVLNCAVPCYQ------PSFSPDERTFATFWISLWSVLCFVSTSTTVATFLIDMERFRYPERPIIFLSACYLFVS
LGFLVRLVVGHSVACNREH-------HYET--TALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSVKSIAVLALS
-VDGDPVAGICYVGNQNLDYLRGFVLAPL-VYLLTGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPASIVVACYLYEQHSR-SWE
RAL-TCQCPAG-----G--QPRAKPEYWVLMLKYLMCLLVGITSGVWIWSGKTVESWRRFTSRC----------
>tr|J9JUF4|J9JUF4_ACYPI Uncharacterized protein OS=Acyrthosiphon pisum GN=LOC100571215 PE=4 SV=1
-------------------------------------------PAAGRCEEITIPMCRGIGYNMTSMPNQLNHETQEEAGMEVHQFWPLVEINCSADLKF
FLCSVYTPICIEE-RPLQACRSVCERARDGCLPVMQRYGFVWPEKMQCDKLPVHGGPELCMAQDVYEQHQHVPVKPTKKPTGSLANKCKPGDEDGCECKC
RPPLVAID----YNRSGV----SVAGVDNCAMPCRA--VLF----TDEEKDFASTWIALWSSICCVTTLMTLTTYTIDTQRFKYPEKPIVFLSGCYLMVS
LGYLIRVYAGHAVACEPDG-------YN-AS--TPCTLVFLLLYFFGMASSIWWVILAFTWFLAAGLKWGNEAIASYSQYFHLAAWLIPTVKSLGVLVMS
-VDGDAFAGVCYVGNQNPDNLKMFVLAPL-VYLALGISFLLGGFVSLFRIRNVIKQQVSKADKLEKLMIRIGVFSVLYTVPASVVIGCHYYEARYM-DRV
AH--CP-CSEP-----D---PDTKPVYTMLMLKYFMTLVMGVTSGVWIWSGKTVGSWKRLSRRL----------
>tr|T1KSM5|T1KSM5_TETUR Uncharacterized protein OS=Tetranychus urticae PE=4 SV=1
-------------------------------------------DGRSKCEEITVPMCRGIGYNMTSMPNQFHHEKQDEAGMEAHQFWPLVEISCSDDLRF
FLCSMYTPICMED--RLPVCRSVCERAQAGCAAIMLQYGFPWPESMDCNNFPVF-GEQLCMDHKNGETPGPGT-VSTQASIPSKPPPPHYPKPPMISINV
QSDYYNHI----G-------------VIDCAQPCHTNFT-------KQE-QSKSSLITIAAFSCLLGSIMVIFTYLTGRERFCYPERSIIFLSACYLIVS
IGFLYPKLTNSTIACDSDKLL-----AGFGTP-WNCTFVFILIYFFSMAASLWWIILTFSWFLSASLKWTVEIINDYSIYFHFIAWSIPAVKSYLAITMK
-IDGEPLAGICLVGNLNSQLLVRFIIAPL-AYLIVGVFFLLAGLFSILRIRKSIRKQINDKCGLDKLMVRIIIFSILHIVPILVVIACNYYQYSHG-IWE
PYH-HCLCNPY------------TPYVTIHLVKYIMLLVPGITTCFWILSGKTLESWWNFLAQK----------
>tr|T1JZ26|T1JZ26_TETUR Uncharacterized protein OS=Tetranychus urticae PE=4 SV=1
-------------------------------------------SDRPKCEEITVPMCRGIGYNMTSMPNQFHHEKQDEAGMEAHQFWPLVEISCSDDLKL
FLCSMYTPICMED--RLPACRSVCERAHAGCAAIMLTYGFPWPESMDCNNFPVYPGEQLCMDQKNGESPGPVK-PLKPSNLSPFQPSTTASRPPMIPINI
QSDYYKHI----G-------------IIDCAQPCQTNFS-------KQE-QSKSSMITIIALCSLFGSLMVIFTYLTDCERFCYPERSIIFLSTSYLMVS
VGFLAPKFFDSAITCDTNKLL-----AGFGTP-WECTVVFALIFFFSMAASFWWIILTFSWFLSASLKWTAEAINDYSPYFHMIAWGIPFMKTCLVIFMQ
-IDGEPLAGICFVGNLNSHLLMRFIIVPL-TYLIVGIIFLFAGLISIVRIRRAIREQITDKFGLDKLMVRIIIFSILHIVPMVLVIICNYYQYSYG-VWE
THY-TCACNPS------------TPYVTIYLFKYIMLLVPGITNFFWILSAKTIKSWWHCISRT----------
>tr|I6XY46|I6XY46_BUGNE Wnt receptor frizzled-like protein 5/8 OS=Bugula neritina PE=2 SV=1
-------------------------------------------FAQKKCEEITIPMCKGIGYNQTYMPNQFNHDNQEEAGMEVHQFWPLVEIQCSPDLQF
FLCSIYTPICVDN-KPLPACRSVCERAKSGCAPLMRQYGFNWPERMRCEDLPEYGDKNLCMDFNTTGTQTTAKKPVVTQPPSKTFQPKPTLIPCLKKCGC
WSPLVSVE----LY-NVV----HTGGIANCAMSCKG--IYF----SAEARNFTVFWIGSWSILCCISTLLTMITFFVDMQRFEYPERPIIFLSGCYLMIS
IGYIIRLIAGQAVACNGD--------YQ-TT--ALCTIVFLLIYFFGMASSIWWVILSFTWFLAAGLKWGQEAIAKYSQYFHLVAWLIPSIKAVTILATS
-IDGDQISGICYVGNQNLANLRGFVIAPL-LYLLLGTSFLLAGFVSLFRIRDAIRQQ-QRTEKLEKLMIRIGVFSVLYTVPATIVIACLFYEQHFR-KWN
RA--CP-CSN----------LGAEPDYSVFMLKYFMCLAVGITSGFWVWSSKTLTSWRTLCSKI----------
>tr|A0A0B5CME5|A0A0B5CME5_OSCLO Frizzled A2 OS=Oscarella lobularis PE=2 SV=1
-------------------------------------------PSTYRCETVTEPRC-RQFYNRTLFPNDLFHDTQAEAGKIFADYDPLINTNCSDSLLI
LLCSRYYPYCLDD--TLPPCRELCECARKGCEPVVRRHQRPWPDDLDCEKFPNSTSE-LCMHNFAPCDPTPTPTVALTTRSSNETSSTFRAPTMPTTTTI
RSCKAPLFV---SQR-KM---DAFAGIEYCKSSCN-------GPFSDEQLDSGSKWLVVLSVLCLVCVLFALPARCVEKRRFRGTEQAVFYLVACLMVVS
VGFIVGASLRRSVACEEVEAN-----AARTSDRVPCIATFILTYYFSMAAGFWWMLLSLQWFLVTAMDWTEKDVSLGENFHHFYVWFTSLCLSVIVFAMS
-LDGDVLANVCSPGNQNETFLTGFVITPIMAILVTSLLLFASGIVQLVARKQKRQPKEAQPTKAKPSLPFLFAFNVINATSYIILASCYFYERAARLDAE
SQLNTLNCL-EKKTCSK--Q---SQIFSIALLKYAAVLLPGIAVPFWAWSKFRLVVWAPKECTR----------
>tr|A0A0B5CV31|A0A0B5CV31_OSCCA Frizzled A2 OS=Oscarella carmela PE=2 SV=1
-------------------------------------------PPSSRCEEIIEPKC-RVFYNRTLFPNSLMHYDQPEASVIFHHYDPLLSNNCSDQLLF
LLCSRYFPLCTIY--TLPPCREVCLCAKYGCEPVLNHHNLSWPDDLSCDGLPNQGGQ-LCMHYGADCNYPATTSSDVVTAEMTTASSLSARTYQPTTEIQ
LKCRAPAFV---SHR-KM---DSFAEISYCKGPCK-------SLFTDDQFTAAFDWLIAWSVLCLVCVLFSLPARCVGKKRFRGPEHAVFCLAICLAFVS
IGYIVGASLNRSVACREEGIN-----AVRTGETAPCMMTFMLTYYFSMAAGLWWTILSLNCFLVFALQWTSKQISNVKTFYHFFVWFVSLLLSAIVFAMG
-LDGDIVANVCFPGNQNNDFLTGFVIIPIAILLTLGTGMFLVAISSRFLRLQRNARLAVTDSVGKPMKVRMFVFTLINSATYIILLSCNLYELSSRSEWQ
R--DFLKCSQGTKICSK--L---SQPFAVILLKYTVILIPGIVIPFWTWGKFNLVEWTPKECVQ----------
>tr|W5N1Z0|W5N1Z0_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEALMNKFGFQWPERLRCENFPVLGDGQICVGQNESDSGVPTVTNPPMHIPAPGTPGTRVYDRPFRCPKV
LTVPSYLN-----Y--------RFLGEVDCAAPCEPSNIGY-MFFSEEEIKFARVWILIWSSLCCASTLFTVTTYLVDMQRFKYPERPIIFLSGCYTMVS
IAFIAGFFLG-KVVC-NEPFTA----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIESNSQYFHLAAWSVPAIKTISILAMG
-IDGDMLSGVCFVGLNSLDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFR-HWE
RSW-SHNCKAL-IPCPLQYTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRRFYTRL----------
>tr|Q90YL7|Q90YL7_DANRE Frizzled homolog 2 OS=Danio rerio GN=fzd2 PE=2 SV=1
-------------------------------------------PDHGFCQPITIPLCTDIAYNQTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEVLMNKFGFQWPEALRCEHFPVLGDGHICVGQNDSMATVSPV-HMPIPGTPSVQLYSTPD-KPFRCPST
LKVPAYLS-----Y--------KFLGEPDCGAPCESSHRAY-MFFTDQEIEFARIWILIWSSLCCASTLFTVTTYIVDMQRFKYPERPIIFLSGCYTMVS
IAYIAGYFLG-KVVC-NESFFP----IVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMG
-IDGDVLSGVCFVGLNNSDALRGFILAPL-LYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFR-QWE
KSW-SMNCKSL-IPCPMQPAPHMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWQKFYVRL----------
>tr|I3KYN8|I3KYN8_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100704773 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNQTIMPNLVGHSNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEALMNKFGFQWPDRLRCENFPVLGDGQICVGQNDSSTATVP--PVISVPGTSDVSIISPRGRPFHCPSV
LKVPPYLN-----Y--------KFLEEKDCAAPCESSSGGK-MFFSDKEIHFSRIWILVWSVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVS
IAYIAGFFLG-RVAC-NDSFTP----IVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAIG
-IEGDVLSGVCFVSLSNLDPLRGFVLAPL-IYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFR-HWE
HSW-SHNCRSL-IPCPMHPGPHMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWHKFYTRL----------
>tr|W5LTW7|W5LTW7_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
-------------------------------------------PDHGFCQAITIPLCTDIAYNQTIMPNLVGHYNQDDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEALMNKFGFQWPERLRCENFPVLGDGHICVGQNDSAPTAPPA-HNMPLPGTPEVFLFSTPDRPFRCPPA
LKVPSYLN-----Y--------KFLGESDCGAPCESSHGVY-MFFTDQEISFARIWILVWSCLCCASTLFTVTTYLVDMQRFKYPERPIIFLSGCYTMVS
IAYITGYFVG-KVVC-NENFFP----IVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMG
-IDGDVLSGVCFVGLNNVDPLRGFVLAPL-IYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFR-HWE
RSW-SKSCKSL-IPCPMQPGPYMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|A0A0P7XUK6|A0A0P7XUK6_9TELE Frizzled-2-like OS=Scleropages formosus GN=Z043_101500 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLVGHYNQEEAGLEVHQFYPLVKVRCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEALMNKFGFQWPERLRCENFPVLGDGHICVGQNDSTVTAP---PVHMPAPGTAGVLLYSTDRPFRCPSV
LKVPPYLN-----Y--------RFLGEADCAAPCEPSSGGY-MFFSQKEIQFARIWILIWSSLCCASTLFTVTTYLVDMQRFKYPERPIIFLSGCYTMVS
IAYIAGFFLG-KVAC-NESFTP----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMG
-IDGDTLSGVCFVGLNSLDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATVVIACFFYEQAFR-QWE
LSW-SQNCKGL-IPCPLQHTPRMMPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|G1K3F4|G1K3F4_XENTR Frizzled-7 (Fragment) OS=Xenopus tropicalis GN=fzd7 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDNSPSGPTARPTPYLPDSITFHPHPNRDFTCPRQ
LKVPPYLG-----Y--------RFLGEKDCGAPCEPGANGL-MYFKEEEVRFARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAYTAGFLLE-RGVC-VERFSE----VAQGTK-EGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-VDGDILSGVCYVGINSVDSLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFR-TWE
KTW-VQTCKGF-VPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRL----------
>tr|H3B255|H3B255_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=LOC102352397 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCEIFPVHGAGDICVGQNTTG------VPTPGPSPHLPEPITLPPSQPFTCPRQ
LKVPSYLN-----Y--------HFLGEKDCGAPCEPTTNGM-MYFMEEEIKFARLWVGIWSILCCFSTLFTVLTYLVDMKRFSYPERPIIFLSGCYFMVA
VAYVVGFLLE-KVVC-IDRFAD----VAQGTK-EGCTILFMILYFFGMASSLWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-VDGDLLSGVCYVGIYSVDSLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR-QWE
KTW-MQTCKSF-VPCPVNDFAPMTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRKFYNKL----------
>sp|Q9IA06|FZD2_CHICK Frizzled-2 (Fragment) OS=Gallus gallus GN=FZD2 PE=2 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSLELKF
FLCSMYAPVCTVL-QAIPPCRSICERRQ-GCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGGSSAALLTSAAPPAAHGTPGAPDRPFHCPRA
LKVPGYLN-----Y--------KFLGEKDCAAPCEPSPDGH-MFFNEDEIRFARVWILVWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVS
VAYIAGFVLE-RVVC-NERFQE----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-IDGDLLSGVCFVGLNGIDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHGG-KTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR-HWE
RSW-SQHCKSL-IPCPLHFTPRMTPDFTVYMIKYLMTLIVGITSGFWIFSGKTLHSWRKFYTRL----------
>tr|H3CDQ8|H3CDQ8_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
-------------------------------------------PEHGFCQQISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCEAFPVHGAGDICVGQNTSEPN----GPSSSSSPYAPDPVTLPPLHQFSCPLQ
LEVPSYMG-----Y--------RFMGVKDCGAPCEPAPTGI-MYFREDEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVA
VAYAAGFFLE-KVVC-VDKFKE----VAQGTK-EGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-VEGDVLTGVCFVGIFNVDSLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR-HWE
RTW-MQICKRF-IPCPTHNFAPMTPDFTVFMIKYLMTMIVGITSGFWVWSGKTLQSWRRFYKHL----------
>tr|A0A093QEJ6|A0A093QEJ6_9PASS Frizzled-7 (Fragment) OS=Manacus vitellinus GN=N305_06724 PE=4 SV=1
-------------------------------------------PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKF
FLCSMYAPVCTVL-QPLPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAPPGPGGAAGRGATAHPTAGYLPDGFSFSCPRQ
LKVPSYLG-----Y--------RFLGERDCGAPCEPAPNGL-MYFKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAYAAGFLLE-RVVC-LERFSE----VAQGTK-EGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-VDGDVLSGVCYVGIYSVDSLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFR-TWE
KTW-LQTCKTY-VPCPSH-FAPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL----------
>tr|G3PRW0|G3PRW0_GASAC Uncharacterized protein OS=Gasterosteus aculeatus PE=4 SV=1
-------------------------------------------PDHGFCQSISVPLCLDLVYNQTIMPNLLGHTNQEEAGLEVHQFYPLVEVQCSMDLRF
FLCSVYLPVCTIL-RALPPCRSLCERARLGCEGVLNRFGFRWPKRLRCEDFPPYGA-ELCIGQNTTNVDDPGSELSPKTPNQTSS------------CPW
QLRVPSYL----NYRFL--------GVDDCGAPCEASPAGL-LYFGENEVRFCRLWVG------------------------------------------
LAYAAGFLLE-RVACADL-NQVG---VVQGTG-GGCTALFLVLYFFSMAGAIWWVVLSFCWFLSAGRKWGIEALEANSHFFHLAAWAVPAVKTLCVLAVG
-VSGDPLTGVCFVGVYDPDAMRSFILAPL-LYLSLGVSFMLAGFGSLLRLRGAVRRAGE-AAALERLTVRIGVFGVLTAVSSAVVVACGVYEQILS-QWW
RA--TQTCRH-V-PCPAGSTDLVRPDFSVFMVKYLMTLIPGIASGGWIWSRKTLRAWIRIFKRP----------
>tr|A0A060YI96|A0A060YI96_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00000734001 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLL--------KF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDTG----SATSQQQEFSCP-------------LQ
LQVPNYLN-----Y--------YFMGVKDCGAPCEPTPNGL-MYFREEEVKFGRLW------------------------------RPIIFLSGCYFMVA
TAYAAGFILE-KVVC-VDKFKD----VAQGTK-EGCTILFMILYFFGMASSIWWVILSFTWFLSAGMKWGHEAIEANSPYFHLAAWAVPAVKTITILAMG
-VDGDLLTGVCYVGINSVDSLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIIIACYFYEQAFR-QWE
KTW-TQICKRF-VPCPPNNFALMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLQSWRRFYKRL----------
>tr|A0A087XK12|A0A087XK12_POEFO Uncharacterized protein OS=Poecilia formosa PE=4 SV=1
-------------------------------------------LEPGFCQPISIPLCTDIAYNRTIMPNLLGHSNQEDAGLEVHQFYPLVQVQCSAELRF
FLCTMYAPVCTVLDRAIPPCRSLCEQARNGCEELMNKFGFQWPDRLRCQNFPPHGAGEICVGQNRSDSAGPAEPNPTARPPFLWSGQR-------FSCPP
QLQVPSRL----SYRFLG--------EEDCGAPCESDPGGL-MHFSQEELKFSRVWVGFWSILCCVSTLFTILTYLLDRRRFVYPERPIIFLSGCSFMVG
LAYSAAF--E-KAVCVARFRKE----VVQGTE-DVCTVLFVVLYFFSMSGSMWWVVLGLSWFLSAGMKWGHEAIQAGSQYFHLAAWVVPALKTVLVLAVG
-VEGDLLSGVCSVGVHSLEGLQGFILAPL-VSLLIGASFLLAGFVSLIRVRSIMKHNG-ETEKLERLMVRIGVFGSVYTASKAIAIACLLYEQAFR-QWD
AT--TQTCKH-ATPCPTRNSPPASPNFTVFMIKYLTTFTVGIGSGFWVWSGKTLQTWRRFSMNG----------
>tr|H3D2B1|H3D2B1_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
-------------------------------------------PDHGFCQQITIPLCTDIAYNQTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-KAIPPCRSICERKQ-GCEALMNKFGFQWPERLRCENFPVQGDEQICVGQNDSTAATVP--PILPGRGTEVPFPPSG---PFRCPPA
LRVPPHLN-----Y--------KFLDEKDCAAPCEPSRGGS-MFFTDKEIHFSRIWILVWSVLC-AFTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVS
IAYIAGYFLG-TVVC-NDSFSP----LVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISIL-MG
-IEGDVLSGVCFVSLSNLDPLRGFVLAPL-IYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFR-HWE
RSW-SQNCRAF-IPCPTHTGTRTTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFYTRL----------
>tr|W5MX40|W5MX40_LEPOC Uncharacterized protein OS=Lepisosteus oculatus GN=FZD1 PE=4 SV=1
-------------------------------------------PEHGFCQTITIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPDSLACESFPVHGAGELCVGQNMSDKSTPMNPTPAVTEEPPNEHRHPP--KHFTCPKA
LQVPPYLN-----Y--------HFLGEDDCGAPCEPLSNGM-MYFSQEELKFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVA
IAYIAGFLLE-KVVC-NDKFD-----VVQGTK-EGCTILFMMLYFFSMASSIWWVILALTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVG
-VDGDVLSGVCFVGINNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
QSW-SQTCKTY-IPCPSYHHPQMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|A0A0P7WRD6|A0A0P7WRD6_9TELE Frizzled-1-like OS=Scleropages formosus GN=Z043_117251 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQ-------
--------------------------RQ-GCEALMNKFGFQWPDSLACERFPVHGAEELCVGQNNSERNVPAD-PTPDVTEPPYPEGSSG--GHFRCPAA
LRVPPYLN-----Y--------RFLGEEDCAAPCEPSPHGV-MYFSQEELKFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVS
IAYVAGFLLE-RVAC-NERFEN----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITVLAVG
-VDGDTLSGVCFVGLSSVDALRGFVLAPL-LYLSIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVVACYFYEQAFR-QWE
WTW-SRSCKTY-VPCPPQRHPQAAPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRRFYRRL----------
>tr|G3PMA2|G3PMA2_GASAC Uncharacterized protein OS=Gasterosteus aculeatus GN=FZD1 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVM-QALPPCRSLCERRQ-GCEALMNKFGFQWPDSLACETFPVHGAGELCVGQNMSDRAEPAGPGLGPDPTVRPDRAAG----QPRCPPS
LSVPHYLK-----Y--------RFLGLDDCGAPCEPSSHGM-MYFSEEELRFSRIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIVFLSGCYTMVS
VAYMAGFLLE-KVVC-NDLFD-----VVQGTK-EGCTILFMMLYFFSMASSIWWVILALTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVG
-VDGDVLSGVCFVGINSVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
RTW-GQTCKAF-VQCPAQSHPNASPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRRFYTRL----------
>tr|B3DJ49|B3DJ49_DANRE Zgc:194761 OS=Danio rerio GN=fzd1 PE=2 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYAPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPESLACESFPVHGG-ELCVGQNTTGPSPPVSPTPDATQAPPEPSQRG----RFQCPPS
LRVPPYLN-----Y--------RFMGEDNCGAPCEPRLHGM-MYFSEDEQKFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVS
IAYIAGFLLE-KVVC-NEQFE-----VVQGTK-EGCTILFMMLYFFSMSSSIWWVILALTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVG
-VDGDVLSGVCFVGINSVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-HWE
QTW-AHSCKTY-VPCPAH-NPQMNPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|A0A060WLD8|A0A060WLD8_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00044406001 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLFMDIAYNETIMPNLLGHMNQEDAGLEVHQFYPLVKVQCSPDLKF
FLCSMYTPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPDSLACESFPVHGAGELCVGQNVSDRSTPIN-PTSDVTESPYGQRRTVK-GQFRCPVA
LRVPPYLN-----Y--------RFLGEEDCGAPCEPSPHGM-MYFSEAELKFAKIWIGIWSVLCCGSTLFTVLTYLVDMQRFSYPERPIIFLSGCYSIVS
LAYIAGFLLG-KVVC-NNRFDS----VIQGTK-EGCTILFMMLYFFSMASSIWWVILALTWFLSAGMKWGHEAIEANSQYFHLVAWAVPAIKTFTILAVG
-VDGDVLSGVCYVGINSVYALRGFVLAPL-IYLFLGTSFLLAGFVSLFRIRTIMKHDS-KTEKLEKLMVRIGIFSVLYTVPATVVIACYFYEQAFR-QWE
KSW-SRTCKNY-VPCPGHHHPQMSPDFTVFMIKYLMMLIVGITSGFWIWSSKTLNSWRRFYTRL----------
>tr|V4CHR5|V4CHR5_LOTGI Uncharacterized protein OS=Lottia gigantea GN=LOTGIDRAFT_139359 PE=4 SV=1
-------------------------------------------EPHGKCEPITIPLCKDIQYNETIMPNILNHQKQDDAGLEVHQFFPLVKVQCSTKLKF
FLCTMYVPVCTVLEDAIPPCRPLCNQARDGCESLMNKFGFEWPESLKCEKLPVSG---LCVGENITEPTSQRPPTGPDIRPPYTGKPGFGSRTRSFNCPD
ELRVPRGF----DYSIKI----GDHLETDCGSPCYN------TFFKSEKREFARWWIGVWSCICLASTLFTVLTFLIDMQRFRYPERPIIFLSGCYFMVA
MAYVVGF--R-EVACMDPFDPPTDTKITQGTK-EGCTILFMMLYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTIAILAMG
-VDGDVLSGVCFTGIFDVDALRGFVLAPL-VYLIIGTSFLLAGFVSLFRIRTIMKSDG-KTDKLEKLMVRIGIFSVLYTVPATIVIACYFYEQSFR-KWM
VT--ATTCEG-HRPCPQNLTSKPWPDFNVFMIKYLMTVIVGITSGVWIWTGKTFMSWRNFYGRI----------
>tr|A0A0L8FPZ8|A0A0L8FPZ8_OCTBM Uncharacterized protein OS=Octopus bimaculoides GN=OCBIM_22011206mg PE=4 SV=1
-------------------------------------------PTHDRCEPITIPLCKGIQYNMTILPNILNHQKQDDAGLEVHQFFPLVKVECSPYLRF
FLCSMYAPVCTMLDHAIPPCQQMCQQAREGCEKLMNRFGFEWPESLRCEKFPRSG---LCVGN-------------------------------------
------------------------YLDRDCGAPCND------MFFTPDKRDFARMWIGICSAICMASTLFTVLTFLIDMTRFRYPERPIIFLSGCYFMVA
LAYVVGF--R-SVACNKPFDPPSLN-ITQGTK-EGCTILFMMLYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTIAILAMG
-VDGDVLSGVCFTGIFDVDALRGFVLAPL-VYLIIGTTFLLAGFVSLFRIRTIMKSDG-KTDKLEKLMVRIGIFSVLYTVPATIVIACLFYEQSFR-QWM
VS--SRVCVT-FFPCPHTDPSRPWPDFTVFMIKYLMTIIVGITSGVWIWTGKTLNSWKRFYCRF----------
>tr|K1PPN7|K1PPN7_CRAGI Frizzled-7 OS=Crassostrea gigas GN=CGI_10027131 PE=4 SV=1
-------------------------------------------PSHEKCELISIPLCKDLPYNWTIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPKLKF
FLCTMYAPVCTVLEEAIPPCRSMCNEARNGCESLMNKFGFEWPDSLKCEKFPESG---MCVGENRTDPVDSTPHPNDDTKFPGYIPETEDNTNSYKTCPK
KYSILPGF----DYRLKV----GSAVYSDCGAPCEN------MYFNEQERHFAKLWIGVWSSICLASTLFTVLTFFVDMTRFRYPERPIIFLSGCYFMVA
LAYVIGF--D-EAAACNRF-------TTQGTK-EWCTILFMMMYFFSMASSIWWVILTLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTIAILAMG
-VDGDTLSGICFTGIFDVDALRGFVLAPL-VYLLLGTSFLLAGFVSLFKIRTIMKSDG-KTDKLEKLMVRIGIFSVLYTVPATIVIACYFYEQASR-TWM
LH--TKECLA-STAPPEESGDKPWPDFNVFMIKYLMTVIVGITSGVWIWTGKTLSSWKRFYAKI----------
>tr|K7IXM9|K7IXM9_NASVI Uncharacterized protein OS=Nasonia vitripennis GN=LOC100122200 PE=4 SV=1
-------------------------------------------APHGKCETITISLCKDMPYNETIMPNLLNHQKQEDAGPEVHQFSPLVKLKCSPDLKF
FLCAMYAPVCTIL-KALPPCRSLCESARNGCERLMNNFGFYWPESMECSKFPENRDGVLCVGKNETTTTEVP--ALIDDVRLPAPEFHPPWRNIGFVCPI
YFKIEEQH----GYSLKV----NK-VEANCGAPCDG----M--FFTETERKFARVWVGTWATLCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVA
LAYVVGWAAG-SISCDKPAPSPV---ITQGTK-EMCTILFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAAPAVKTVSILAMG
-VEGDILSGVCYVGLWNVEALRGFVLAPL-VYLVLGTVFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGIFSVLYTVPALIVIACLFYEQAYF-NWM
LT--KEMCSKPI-PCPMGRDLSRKPDFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFHHI----------
>tr|L7M581|L7M581_9ACAR Putative smoothened OS=Rhipicephalus pulchellus PE=2 SV=1
-------------------------------------------PHHGRCEPITIPLCKDIQYNETIMPNLLNHQKQEDAGMEVHQFFPLVKVKCSPDLQF
FLCSMYAPVCTIL-YPIPPCRSLCMSAREGCEHLMNKFGFKWPESLECDKFPEVGTEKLCVGENVTEHRINHTPTSPNSTGLLVNHG--------FLCPR
EFRVPLGL----DYVFRI----GK-EEKNCGMPCHH----M--FFRGENLKFSRYWIGAWSIQCMVSTLFTVLTFLIDMQRFRYPERPIIFLSFCNLMVS
STYFAGFVLG-QVACNEPFEVPG--GITQNNK-EACTVMFMVLYFFSMAGSIWWVVLTLTWFLAAGLKWGHEAIESNSQYFHLAAWTIPAVKTITILAMG
-VEGDVLSGVCYVGLWNMDALRGFVLAPL-VYLALGKVFLMAGFISLCHIRTVMKHDGK-TDKLEKLMVRIGIFSFLYTLPALTVLCCYFYEQAHF-DWM
LA--WRVNAE-I-PCPEPDRTLRLPEFYVFMIKYLGILIVGITSGVWIWSGKTFASWRNFYARL----------
>tr|A0A087T8F5|A0A087T8F5_9ARAC Frizzled-7-A (Fragment) OS=Stegodyphus mimosarum GN=X975_04090 PE=4 SV=1
-------------------------------------------PHHGRCEPITIPLCKDIPYNETIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPDLQF
FLCTMYAPVCTII-RAIPPCRSLCMKAREGCELLMNNFGFQWPKSLDCDKFPEAGGDMLCVGENNTDRAQHPAPGSGYPLTPVRNNNTITK-GRKFICPE
EFKVPKGL----GYVFRV----EA-EEKDCGAPCDG----M--FFTTQEKKFARTWIGVWAILCMGSTLFTVLTFLIDMHRFRYPERPIICLSACYFMVA
ITYAAGFVWG-HVSCNEPFLPPN--NITQGND-KWCTISFMFLYFFSMSSSIWWVILTLTWFLSAGLKWGHEAIENNSQYFHLAAWTVPAVKTIAILAMR
-VEGDVLSGVCFVGLWNRDSLRAFVLVPL-VYLVLGTLFLLAGFVSLCHIRTIMKHDGR-TDKLEKLMIRIGVFSVLYTVPAVVVLACYVYETYYF-FWM
VS--REKCNR-I-PCPDVYNFWPKPDFAVFMIKYLMTLMVGITSGFWIWSGKTFTSWKNVYLRL----------
>tr|T1JLV3|T1JLV3_STRMM Uncharacterized protein OS=Strigamia maritima PE=4 SV=1
-------------------------------------------PHHGRCEPITIPLCKDIQYNETIMPNLLNHQKQEDAGLEVHQFFPLVKVQCSPDLQF
FLCSMYAPVCTILDQAIPPCRSLCMSARVGCEGLMNKFGFQWPESLDCSKFPEAGSHDICVGENNTQSRGTVT-HKGGSSGVQNPMYTQKPKAFGFVCPE
HFKVPKSN----NYVLRV----GDDVRPDCGAPCHE------MFFTEKERHFSRIWIGVWSILCMISTLFTVLTYLVDTERFRYPERPIIFLSVCYFIVA
LTYTVGF--G-EISCNEPFDPSKRSLITQGTR-GSCSFLFMLLYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANCQYFHLAAWAVPAVKTITILAMG
-IEGDVLSGVCFVGVWNSTTLRCFLLIPL-VYLFIGTIFLLAGFVSLFRIRTIMKHDG-KTDKLEKLMIRIGIFSVLYTVPATIVIGCYFYEQNNM-SWM
VS--NDICKR-KIPCPEDDNFWPKPDFTVFMIKYLMSLIVGITSGFWVWSGKTFSSWKNFYVKI----------
>tr|H2Y9A2|H2Y9A2_CIOSA Uncharacterized protein OS=Ciona savignyi GN=Csa.5405 PE=4 SV=1
-------------------------------------------VHNGKCELITLSICKGIRYNETIFPNVLGHQDQAEAGLQINQFYPLVKVGCSKTLQS
FLCSVYTPMCSIY-QAFPPCRHMCEEAR-ACEGIMKQFRFSWPRDLECSRFPIKTEDSLCFGTDISPSEEIPAFDTGRLCLSQAGFTCP----AHMLVPS
TNDLNYEF--MD--------------AEGCGVPCDAKKL-M--YWTESEKQFANLWIGCWSFICVISTLFTVLTYLIDMPRFMYPERPIIFLSGCYLIVA
IAYIAGFFLR-TVSCRQFHTSICPVDVTQGAR-AGCTVLFMMVYFFSMASSIWWVVLTITWFLAAGLKWGNEAIEAKSPYFHGAAWSIPAIQTIVVLISS
-IEGDLLSGICFVGVHNSKHLLWFLLVPL-IYLFVGTCFLVAGFVAMFNIRNVVKHSGGKVEKLERLMVRIGVFSVLYTVPATVMIACYFYEQMNR-SWQ
KG--AQNCRK-V-PCPCEKHKGNKPDFIVFIIKYFVMLIVGITSGFWIWSSKTVESWSNFKEQL----------
>tr|Q4H315|Q4H315_CIOIN Frizzled receptor OS=Ciona intestinalis GN=Ci-Orphan Fz-a PE=2 SV=1
-------------------------------------------QHEGKCEPITLSICKGIQYNVTIFPNILGHQDQSEAGLQLNQFYPLVKVGCSPTLQL
FLCSVYTPICSTY-RAFPPCRHMFEEAK-ACEKLMKKFDFSWPRDLDCSKFPLKTEGDLCFGRDIIPSTITPTYVDRRQCLTGVGF----------SCPA
HMTVHEND----SYEFM--------ETENCGAPCDSKRL-M--FWTEGEKQFANLWIGCWSFICVISTLFTVLTYLIDMPRFLYPERPIIFLSGCYLVVA
IAYIVGFFLR-SVACKQFSSSTCSADVTQGAR-AGCTVLFMMVYFFSMASSIWWVVLTITWFLAAGLKWGNEAIEAKSPYFHGTAWSLPAIQTVIVLISS
-IEGDLLSGVCFVGVYNTKHLLWFLLVPL-IYLLVGTCFLVAGFVAMFNIRNVVKHNGGKVEKLERLMVRIGVFSVLYTVPATVMIACYFYEQMNR-SWQ
KG--AENCRK-V-PCPCEKHVGNKPDFIVFIIKYFVMLIVGITSGFWIWSSKTVESWANFKDNL----------
>tr|A0A068FU94|A0A068FU94_9CNID Frizzled 1 OS=Rhopilema esculentum GN=FZD-1 PE=2 SV=1
-------------------------------------------ISPSRCEPITIPLCQDIQYNKTVFPNLLSHRNQEEAGLEVHQFFPLVKVECSKYLKF
FLCSVYVPICSDK-TPIPPCRILCKVARDGCLKLMNSFGFQWPEALQCERYPEMGSGSLCVGKNFTEKERGGDKKPSGNGNNGGNGGNTNRGKPIFRCPS
VQNKSDDK----HYNFM--------GEMGCAGECTN----I--YFTTKERDFARKWILFWALMCIISTTFSLLTYLIDMKRFHYPYKPIIFLCGCYFVIA
VVYIVGYVAD-DISCHKVK------SYNQGTE-AGCTVVFMFLYFFTMASAIWWVILTLTWFLAAGMKWSHEAIEGNSQYFHAAAWALPAAKTIAILAMH
-VDGDELSGICFVGGSNLQALRGFLLAPL-VYLVLGTFFLLAGFISLVRIRSVLKHDQLKTDKLTRLMIRIGVFSILYTLPAIIVIACLFYEQAYR-TWD
SA--RSWCNDM---SSQI-IGVERPDFAVYMIKFLMMLMVGITSGFWIWSGKTLTSWKRFYYVR----------
>tr|Q3LAK2|Q3LAK2_HYDEC Frizzled receptor OS=Hydractinia echinata GN=frizzled-1 PE=2 SV=1
-------------------------------------------GQKTTCVSLGLRLCQNLGYNATMFPNSLEHRNMENASTELDNFLPLVKIRCAKEIEF
FLCSVYLPVCLDS-GPLPPCREVCERAQRGCIKLMTQYGFPWPEYLRCSRFPKKVEDRLCVDKPFKEPGTNGN-NGNNGINTGGIPVNPSHATYDDYRCP
AKQQKETK----HYKFM--------GTEKCASLCTP----I--YFTHKEKDFARNWVLFWSVVCMLSTAFTLLAFIVDMPRFRYPERPIIFLSGCYFIVA
IAFISGPVSD-AIACHKTD------DLNQGTD-ASCTIVFMLIYFFLMSASIWWVILTLTWFLAAGLKWGHEAIEGSSQYFHAAAWAIPAAKTIAVLAMN
-TDGDILAGVCFVGGKNVNALRGFVLAPL-VYLVVESFFLFAGFISLIQIRKVLKDDSLRAEKLTRLMVRIGIFSILYSLPAIIVIACLFYEQTYR-EWD
SS--SAWCDEK---CFEF-SGKSRPDFAVFMIKYLMLLMVGITSGFWIWSGKTIQSWRRFYYNK----------
>tr|Q9I8V7|Q9I8V7_DANRE Frizzled X OS=Danio rerio GN=fzd9b PE=2 SV=1
-------------------------------------------RP-AKCEPIVIPMCQGIGYNLTRMPNFMDHDNQREAAIKLNEFAPLVEYGCDVHLRF
FLCSLYAPMCTDQ-TSIPACRPMCEQARQECSPIMEKFNYAWPESLNCSKLPTRNDNALCMEAPENDTKTET--KKGEGMLPVPPRPR------QPGAGN
ARSGGTMGVCENKFQ-------YVEKSETCAPRCSSA-VD--VFWSRQDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYS
VAFIIRSVAGANIACDRENGE-----IQEGLE-TGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIESHSSYFHMAAWGIPALKTIVILTMR
-VAGDELTGLCYVGSMDV-ALTGFVLVPL-CYLVIGTSFILTGFVALFHIRKVMK-TETNTEKLEKLMVKIGIYSILYTVPATCVIICYFYERLNM-YWK
FRGLQSKCTTF-----GRLD-SSVPTVAVFILKIFMSLVVGITSGVWVWSSKTLQTWQGLC-SR----------
>tr|A0A060WZU3|A0A060WZU3_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00013921001 PE=4 SV=1
-------------------------------------------RH-AKCEPITIPMCQGIGYNMTRMPNFMKYASQAEASIKLNEFSPLVEYGCDIHLRF
FLCSLYVPMCTDK-TTIPACRPMCEQARQKCSPIMEKFSFGWPDSLDCSKLPTKNDNSLCMEAPENDTKQET--KKGEGMLPVPPRPRQ-----PSSGTS
GRSGTSLGSCENKFQ-------YVEKSQSCAPRCSSA-VD--VFWSKKDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDPQRFQYPERPIIFLSMCYNVYS
VAFVIRSVAGANIACDRENGE-----IQEGLE-TGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIEAHSSYFHMAAWGIPAMKTIVILTMR
-VAGDELTGLCYVGSMDV-ALTGFVLIPL-CYLVIGTSFILTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATCVIICYFYERLNM-YWK
FRVLESKCVSF-----GRLE-ESVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLC-NR----------
>tr|V8N6J5|V8N6J5_OPHHA Frizzled-10 (Fragment) OS=Ophiophagus hannah GN=FZD10 PE=4 SV=1
-------------------------------------------GD-GRCQPIEIPMCKDIGYNMTRMPNLMGHEDQQDAAIQLHEFAPLVEYGCHGHLKF
FLCSLYAPMCTEQ-TPIPACRVMCEQARLKCSPIMEQFNFRWPDSLDCSKLPNKNDNYLCMEAPSNGSEEP---PRGSSMLPPMLWPQRPH-SAAHDLTQ
QKDGLGRLSCENKFH-------HVEKSGSCAPLCTTG-VD--VYWSWEDKRFAVIWMAVWSILCFFSSAFTVLTFLVDPQRFKYPERPIIFLSMCYCVYS
VGYIARLFSGANIACNPDSGQ-----IQEGLE-TGCTLVFLILYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMR
-VAGDELTGLCYIGSMDV-ALTGFVLVPL-CYLILGTSFILSGFVALFHIRRVMK-TGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM-YWR
VLATQQKCKVN-----TKMS-DSIPAVEIFMVKIFMLLVVGITSGVWIWTSKTLQSWQGVC-SR----------
>tr|A0A0K2T5H1|A0A0K2T5H1_LEPSM Uncharacterized protein OS=Lepeophtheirus salmonis PE=4 SV=1
-------------------------------------------ALGGACEPIKIEAC-LWGYNETSMPNLANHVKQADAKVEFDTFAPLMDSGCSNELPF
FLCAIYTPMCAPLAVVVGPCRPLCEKVRANCEPLLNKMGFSWPQHFECSLFHPENKHEMCMKGPGESATLPRLSISTLHTFRTNHLFRERVNMRNPATTT
HSECRHLKRSTQ-YR-RV---E---RLGTCIPLCDQ---D--IFFDGYQKNFAVIWMTVWSSLCLGSTLFTLVTYC-LPEQFKFPEKSVIFITFCYSLHA
LGYVFRLLGGRAIACQSSDED-----TQEGLRNEYCVVNALLLFYPFHAASTWWTIGTFTWLLSRF----DLLVENYAPIYHLYAWGLPALLSVASLVWK
-IDASELTGMCSIGNQNEDNLLFFIIIPEALQFGLNIIFFLLGLIVSS--KNKK------------IYSKIGVFWILYTLPKACVIGCISYEYLNRGAWL
DVT-----------------KINRPNVEIFMLHICMSLVIGITTCYWIWSEQTF--------------------
>tr|H9G9X6|H9G9X6_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=FZD7 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTILPNLLGHTSQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTVL-QAIPPCRSLCERRH-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDTSSSSGGERRGAGVAPGSPATASYVFEFSCPRQ
LKVPPYLG-----Y--------RFLGERDCGAPCEPDNVGL-MYFKQAEVRFARLLIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAYVAGFLLE-RVVC-VERFSE----VVQGTK-EGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-VDGDVLSGVCYVGLYSVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFR-TWE
KTW-LQNCKSY-ITCPAANFAPMSPDFTVFLIKYLMTMIVGITTGFWIWTGKTLQSWRRFYHRL----------
>tr|A3QK10|A3QK10_DANRE Uncharacterized protein (Fragment) OS=Danio rerio GN=fzd9a PE=4 SV=1
-------------------------------------------RP-GKCEPITIPMCQGIGYNMTRMPNLLNYESQEEASIKLNEFAPLVKYGCDIHLQF
FLCSLYVPMCAEQ-ASIPACRPMCEQARQRCSPIMEQFSFSWPDSLDCSKLPTNNDNALCIEAPENDTQPET--KKGEGMLPVPPRSR------QPTTVS
GRISSISQSCENKFQ-------YVDKSESCAPRCTPT-VD--VYWSRQDKDFAFIWMVVWSTLCFVSTAFTVLTFLLDPQRFQYPERPIIFLSMCYNIYS
VAFIIRSVAGANIACDRENGE-----IREGLE-TGCTIVFLILYYFGMASSIWWVILTLTWFLAAGRKWGHEAIEAHSSYFHMAAWGIPAVKTIVILTMR
-VAGDELTGLCYVGSMDS-ALTGFVLIPL-CYLIVGTSFILTGFVALFHIRKIMK-TGTNTEKLEKLMVKIGVFSILYTVPATIVIICYFYERLNM-YWK
FRALENKCVSF-----GRLD-SSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLY-NR----------
>tr|W5UIU1|W5UIU1_ICTPU Frizzled-9 OS=Ictalurus punctatus GN=Fzd9 PE=2 SV=1
-------------------------------------------RP-AKCEPITIPMCQGIGYNMTRMPNFMKYDSQEEARIKLSEFAPLVEYGCDVHLRF
FLCSLYVPMCTDK-NTIPACRPMCEQARQKCSPIMEKFSFSWPDSLDCSKLPTNNDNSLCIEAPENDTVPET--RKGEGMLPVPARP---------RQSG
GGHGQSSGTCENKFQ-------YVERSKSCAPRCTPT-VD--VFWSRQDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDAQRFQYPERPIIFLSMCYNVYS
VAFIIRSVAGANIACDRENGQ-----IQEGLE-TGCTIVFLILYYFGTASSIWWVILTLTWFLAAGRKWGHEAIEAHSSYFHMIAWGIPALKTIIILTMR
-VAGDELTGLCYVGSMDA-ALTGFVLIPL-CYLIIGTSFVLTGFVALFHIRKIMK-TETNTEKLEKLMFKIGIFSVLYTVPATCVIICYFYERLNM-YWK
FRALESKCVSF-----GRLE-SSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLC-TR----------
>tr|B4J063|B4J063_DROGR GH17099 OS=Drosophila grimshawi GN=Dgri\GH17099 PE=4 SV=1
-------------------------------------------PHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSADLQL
FLCSLYVPVCTIL-RPIPPCRSLCESAR-VCETLMKTYNFNWPENLECSKFPIHGGEDLCVAENTTSSGSSSSTPAAPIRPVPKVTSRKHQRNIGFVCPV
QLKTPLGM----GYELKV----GK-DLHDCGAPCHA----M--FFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVG
CAYVAGLGAG-SVSCREPFPPPV--KITQGHR-TACTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALA
-VEGDILSGVCFVGQLDTHSLGGFLILPL-IYLSIGALFLLAGFISLFRIRTVMKTDGR-TDKLERLMLRIGFFSGLFILPALGLLGCLFYEYYNF-EWM
IQ--RDICKP-I-PCPAAGTPEARPIFQIYMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL----------
>tr|A0A0L7L2K0|A0A0L7L2K0_9NEOP Frizzled-2 (Fragment) OS=Operophtera brumata GN=OBRU01_15728 PE=4 SV=1
-------------------------------------------------------MCRGVGYNLTSFPNALDHDTQEEAGLEVHQYWPLVEIKCSSDLKF
FLCSVYTPICIED--PLPACRSVCERARAGCAPLMQKYGFQWPERMACERLPRA-GDHLCMEENDRAQVSYRPYTRVGLQWPERMACERLPPERMACERL
PRSGDPDHLCMEQVSY------RPYTRVGLQWPERMAPDH--LCMKDRAQEFAAVWVALWSGLCAASTLMTLTTFLIDSQRFKYPERPIVYLSACYFMVA
LGHLARLVLERSIACDGALLRT-------AAG-GACTLIFVLVYFFGMASSIWWVVLSFAWFLAAGLKWGNEAIAGHAQYYHLAAWLVPAAKTIAVLLAG
-VDGDPVAGICYVGNSSPENLKKYVLAPL-VYFALGATFLLAGFVSLFRIRSVIKRQGSKADKLEKLMIRIGVFSVLYAVPAGVVIGCLAYEAGGY-RWM
RRV-ACGPACG-----P---LY-----SALMLKYFMTLAVGITSGVWIWSGKTLESWRR---------------
>tr|T1DF47|T1DF47_SCHMD Fzd-4-2 OS=Schmidtea mediterranea PE=2 SV=1
-------------------------------------------DVYNRCDKINQQIC-GLQYDKTRMPNSVGITNQEDSAKRMNDYFPLINAQCSYYFRF
FLCTFYFPMCTDMTKTLLPCREMCEKVQIRCEPFMKAFKLKWPAELNCKKFPMNT--EICIRPTNYDLDRNL--SFNANGLDYLKKHYPKWRLENFETEI
NLKCLDSHVSVKSAV-DN---RTKSKSYSCVPKCDS---N--IWYSSSDKNLARIWYFIWTILCLISSIVAIATFVFDKVRFLYPERPIIFIVLCYGCIC
VFNLFHLGLDRRLVCQILHTH--PNDLMKEGY-PMCTLTFLGMYYFEMVAALWWLMLAISCYLASERKWSCEGLERISNAMHIVSWTLPAISTTIVLILH
-IDPDELLGSCYVGRQNSRSNLFFILIPRILCFLLGSVLLILSFRSLMVLRQNIAHNKQNQQSLEKFIAKTGIFCGVYGVPMTCYIGCQLYYYLHIDEWN
KLGDGEECVNKDKSCLK--G-LPLPLVEVRLLEIFSTLVIGITSGMWMWNKKTLLNLHRYLVSE----------
>tr|T1DBN2|T1DBN2_9PLAT Fzd-4-2 OS=Dendrocoelum lacteum PE=2 SV=1
-------------------------------------------DLYNQCVIIKDPAC-GIQYTKTKMPNLAGITNQEDSAKRLHDYHPLINAECSNYFRF
FLCTVYFPMCSDAPSIVYPCKQLCLYAESRCEPYLRAFQLPWPNELNCQRFPTNS--TMCIEPKNYDLDLHLR-RFNPGDIDHIKKLYPQWKDIVEMVET
TVKCSPPFVSRPYYL-HI---SNQSTKFSCVLRCDA---N--LLYNSSDKYLAKVWLLVWALSGLISSIVAIATFLFDKSRFKYPERPIVFIVICYGCVC
VFHLIQLMLGKRMICQPLYSN--PKEIMRESA-PLCTLMFLGSYYFETVATLWWLMLAVSCFLASSRKWSAEALEGISNIMHMISWMIPALKVTIILIIH
-IDSDELMGMCFVGRHNALSNLLFILLPRITYFFIGVMLLLWSFRSLVLIRKDLTQPGQNQQSLDKFIVKTGIFCGVYGIPMICYIGCQIYNYLNIDNWN
NIGKESRCLSKDTSCTN--H-LSLPLIEVRLLETFSSLVIGITSAMWMWNKKTFITFSQLCIKK----------
>tr|D6WJY3|D6WJY3_TRICA Frizzled OS=Tribolium castaneum GN=Fz PE=4 SV=1
-------------------------------------------PPHDKCKPITVPFCIDVPYNSTIFPNLVGHNTQEDAGYEVHQYFPLIKINCSADLHL
FLCSVFVPVCTIL-KPVPPCRSLCLSAKSGCEGIMRKFGYNWPENLDCNQYPENSN--LCVEKHNISVTPTPANEPPDYPKSKFDFKGVRAPRDFGFVCP
LQFEVKNM----DYSLKV----DK-VVKNCGAPCHM----M--FFNENKQKFSRVWIGTWAVLCSASCLFTVCTFLIDTNRFRYPERPIIFLSVCYLMVA
LAYVVGFIAG-SIACKEPPISDE--GITQGTK-ELCTILFMVLYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAIPAVKTITILAMG
-VDGDVLSGVCYVGIWNVDALRIFILIPL-IYLVFGLVFLTSGLISLFRIRTVMKHDGK-TDKLEKLMIRIGVFSILYTVPAMMVIACLFYEQFNF-NWM
LT--HDMCVK-V-PCPQDRE-YSHPLFPIFMIKYLMYMIVGITSSVWIWSGKTVHSWKVFLNRL----------
>tr|A0A0K2VH93|A0A0K2VH93_LEPSM Frizzledlike [Megachile rotundata] OS=Lepeophtheirus salmonis PE=4 SV=1
-------------------------------------------IQHGKCEAIGMPLCRDLPYNSTIFPNLLNHATQDEASESIRPYGPIVKLKCSSDFQL
FLCSLYTPLCTIL-HPIPPCKGLCLSAKLGCEDLMKEFDLPWHREFSCDHLPVEG--SLCIGRERTDFSMTDLASYKENEQKKDSSVNNG--SGEFICPA
QLKIPTER----EYVLRL----DVQRVKNCGAPCRK----M--FFNEKEIAFANNWIGLWSVLCLLSTSFTLLTFAVDPGRFPYPERPIIYLSICYFMIS
LTYIIGYASD-SIACNKAFDNDPSI-IKQGSL-WRCTLLAMILYFFTIASGLWWVILTISWFLSAGLKWGVEAIDIKSHWFHSIAWIPPSFLTVAILVTK
-IDGDVLSGVCFVGLWDVGSLRYFILTPI-SCLVVGTFFLIIGMGSLVKIRTIMKLDGK-TDKLERLIARIGTFFLLYTIPAIIVISCLFYEQHHF-DWM
IL--ERICRDKI-PCRYRIPITTKPNFYIFMTKYLMFLMTGIFSGFWVWSAKTVVTWKNFYRKL----------
>tr|U4U4I1|U4U4I1_DENPD Uncharacterized protein OS=Dendroctonus ponderosae GN=D910_05350 PE=4 SV=1
-------------------------------------------PTHGKCQPITVPTCLNIPYNQTIMPNLVGHSSQDEAGLEMNQYMSLIKVACSPDIQF
FLCSVYAPVCTIL-HPIPPCRSLCLSAKNGCEQIMKRFGYSWPEVLRCENFPETSD-DLCVGEDKQ-VSVNQQSSGADKKNRILDQFEPPAKNFGFVCPE
QFKVPAVL----EYSFKV----DK-VEKNCGAPCDL----M--FFTEHKRQFSKLWIGIWAILCSISCLFTICTFLIDTDRFRYPERPIIFLSVCYFMVA
GAYLVGFLAN-TIACREPFASKY--GITQGTK-ESCTILFMVLYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLVAWAIPGIKTIAILALG
-VDGDVLSGVCYVGIWNVDTMRIFVLLPL-IYLIFGTVFLMSGFVSLFRIRTVMKHEGK-TEKLEKLMIRIGIFSVLYTLPALIVIGCLFYENSYY-DWM
RT--TDICHN-V-PCPISKPTKHYPYFEAFMVKYLMTMIVGITSSVWIWSGKTVHSWRVFFNGL----------
>tr|T1DF93|T1DF93_9PLAT Fzd-4-1b OS=Dendrocoelum lacteum PE=2 SV=1
-------------------------------------------DVYGQCSLITEPVCQDIQYTHTKMPNLIGILSQEEASKRIRDYYALINLQCSQYLKL
YLCSVYFPVCDKV--NIQPCRRLCHHVKSRCEPFMQNTQLTWPDELNCEKLPESTK--LCVAPDSFSLDKDHNKMSNYVEMKKKLFEQLKVLKKVNLLSD
LKCLPSQF--I------I----GETPNISCAQNCDA---D--VKFNDNDKTFANIWLIIWSLLCLLSSLFTIITFSCNTNRFMYPEKPIVFLSICYFFHS
CGNLLGVILGRNVICRPF--------VGNGNE-TWCKIIFLMVYFFSSASALWWVVLTVTWFLSASRHWGNEAIESISSILHLLSWGIPALKSIFVLILH
-IDADELTGQCFVGNNDKEALIGFVLIPQ-IYLLIGMIFLGLGYYSILKVRKSFLQQPNNIKRLEKLMAKIGVFSILYIIPVTCTIASYVIDVLKT-YFD
LIL-NV---VYPDCVTAKLIQSALPSVEMRMLRIFMTLVIGITSGIWIWGNKKTFR------NC----------
>tr|B1NWW0|B1NWW0_SCHMD Frizzled receptor-like protein (Fragment) OS=Schmidtea mediterranea GN=Frz-d PE=2 SV=1
-----------------------------------------------------EPECQDVHYSNTSMPNLVGSYSQTEASKRFRDFNPLINIKCSNYLKL
FLCSVYFPMCETD--TVKPCRHLCNHVKERCEPLMKETKLTWSEELDCEKFPERGK--ICLTPDSFSQDEFHPPANSQEDSYQDLYRKLQLYQKMSDMVG
AQCLPSEV--N------I----GQTPNISCAQICSA---N--VQFNAHDKVFANIWLLGWSVLCFFSCLLTIIVFSCNTNRFLYPEKPIVFLSICYFFYA
SGNLFGAILGRVVACRAF--------VGSGRE-TWCKINFLMIYFFGSASALWWVVLTITWFLSASRHWGYEAIESISSMLHLVSWAIPALKSIFILILH
-IDADELTGQCFVGNSNNKVLWGFVIVPN-IYLFIGIVFLTMGYISLLKVRRSFLQRPNNLKRLEKLMAKIGVFSILYVLPVLCTIVSYIVDAYKM-NFD
ITL-KA---LFPNCIGRNILQPVLPSVEMRMLRIFMNLVIGITSGIWIWGNKKTVK------SC----------
>tr|C6ZDD0|C6ZDD0_SCHJA Frizzled 7 OS=Schistosoma japonicum PE=2 SV=1
-------------------------------------------AETPKCEPIRIKACQDLPYNITIFPNDMGHATQDDAAQEIGQYTPLVRTTCSSSLKL
FLCSLFFPVCTGM-KPLPPCRSLCEQNRKDCEPLMRGFHFEWPEIMNCDRFPEDS---LCIAENKTEKRVSK--EPSFVCPV------------------
HMRVPPSF----EFRIRM----SNQVIHDCGIPCDD----F--LFGDSSRRFSRLWIGLWSCLCAASTLFTVLTFLIDMPRFQYPERPIIFLSACYLMVA
LTYVAGFILN-EVACSGPFPAPQSL-ITQGTK-EGCIVLFMLLYFFSMASSIWWVVLTITWYLAAKCHWAHEAISRNAQYLHSAAWAIPAAKTIGILALG
-VDGDPLSGVCFTGLTDPVILRAFLIAPL-LYLLIGTCFLFAGFVSLFKIRTIIKTGGK-TDDLEKLIMRIGVFSLLYIVPALVVIACYLHESRMS-KWM
LT--TTECRKVS-ICPGHISALERPEFELFMIKYLMTLIVGITSGIWIWSGKTLVSWQRFFARI----------
>tr|T1E1C6|T1E1C6_SCHMD Fzd-1/2/7 OS=Schmidtea mediterranea PE=2 SV=1
-------------------------------------------N-QPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQL
FLCSLYFPVCTIM-KALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN---LCIRDNQTEKESAP--NVSLSCPK------------------
SLQIPVSY----DFKIRL----QNSVIQDCGIPCNR----Y--YFNENLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVG
LTYVAGFFLN-KVACAGPFTNKDST-VVQGTK-ESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALS
-VDGDPLTGVCFTGLSDPSTLRGFLIAPL-IYLLIGTGFLIAGFVSMFEIRTIIKTGGK-TDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNL-KWM
QR--LIDCRSAK-IHDHKLIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL----------
>tr|T1E112|T1E112_9PLAT Fzd-1/2/7 OS=Dendrocoelum lacteum PE=2 SV=1
-------------------------------------------N-QAKCEKIKVQACQGLLYDMTLFPNSMGHSTQDEAASEINEYLPLLRIKCHNSLQL
FLCSLYFPVCTNM-IALPPCRSLCEDIKKSCEPILKKFYFKWPSNMACDKYPENN---LCIKDNQAEKKPNE--TMSISCPK------------------
PLKVPPSY----DFKVRY----SNSVIPDCGIPCNR----Y--FFNENLKKFTRVWVALWSFLCVASTLFTVLTFLIDMQRFQYPERPIIFLSACYLVVG
LTYVAGFFLN-RVACAGPFSNSDLR-VVQGTK-ESCIIMFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIERNSQYFHFAAWAIPAGKTIGILALS
-VDGDPLTGVCFTGLSDPNALQGFLIAPL-LYLLIGTAFLIAGFVSMFEIRSIIKTGGK-TDKLEKLITRIGIFSVLYIVPAVVVIACYFHESMNL-KWM
QR--WVDCRSPK-NVDLNYLLNQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFLSKL----------
>tr|A0A0R3UAF3|A0A0R3UAF3_9CEST Uncharacterized protein OS=Mesocestoides corti PE=4 SV=1
-------------------------------------------DDQAQCTPIREPVC-GLQYTHTKMPNWVKMTSQEEAAKRMIDYKSLLNINCSHYLKL
FLCTIYFPMCTQV-SALKPCKPLCLHVRRRCEPIMQQFQFSWPAELSCDDLPESP--KLCIEPDGYALDTQKP-VLPPASANMAGGSLASLGNIVLASEA
NRGCSAAEFPAT-----------YFSNDTCLTYCGA---D--LYYRPADKKFARAWLLGWSILCVVSSALTFLTFIVDRSRLQYPERPVLYLAACYFAIG
VGYILQYGLGPVVTCRSVQSS--DSNLLTGGQ-TWCTVGFLISYYFGMAGNFWWVMLSLAWYLSTSRKWGHEGVESVSSVFHMFAWALPAIQSILVLILH
-IDADELTGTCYTGFHSETALMFCVLLPQAASLILGLLLLSVGFAAVFRVRRKLKTPSESRRRLEKSIAKLGVFVVLYTFPMACLLAGNLYEYLGQPRWR
AALRRPHCLSPIPECHP--D--DSPSSEAAMLRIFMSFVVGITSGMWVWNKKTFVSWKRAICRE----------
>tr|A0A0R3W5N6|A0A0R3W5N6_TAEAS Uncharacterized protein OS=Taenia asiatica PE=4 SV=1
-------------------------------------------DDQAQCTPIREPVC-GLQYTDTRMPNWVKMTSQEEAAKRMIDYKSLLNINCSHYLKL
FLCTIYFPMCAPV-TPLKPCKSLCLHVRSRCEPFMQQFQFSWPAELACDDLPEPP--DLCIQPDGYALDAQKP-VLPTASSNLASLQRMYPSAPVVSSAS
SNVCSGAEFSAA-----------HFSNDTCFTYCGA---D--LFYRPGDKKFARAWLLGWSVLCVASSALTFFTFFVDGSRLQYPERPVLYLAACYFVIG
VGYILQYALGPRVTCRSLQTG--DSNLLMGGQ-TWCTVGFLISYYFGMASNFWWVMLSLAWYLSTSRKWGHEGVESVSSVFHMFAWALPAIQAILILILH
-IDADELTGTCYTGFHSETSLMFGVLLPQAVCLILGLLLLSVGFAAVFRVRRKLKAPSESRRRLEKSIAKLGVFVVLYTFPMACLLASNLYEYLGQPRWR
AALRRPHCLSPLPECHP--K--DSPSSEAAMLRIFMSFVVGITSGMWVWNKKTLVSWNRAIFRG----------
>tr|E2BT31|E2BT31_HARSA Frizzled-4 OS=Harpegnathos saltator GN=EAI_00682 PE=4 SV=1
----------------------------------------------ISPLNLAIEMC-GLGYNVTAMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHL
FLCSVYAPMCTDKTSPIGPCRGLCEQVRVRCFPVLQGFGFPWPAALNCSKFPPENNHHMCMEGPGEPGPVSPIQAIGASNGP------------------
-WGCSWYAKSGL-YI-FL---N---RSGRCAAACDA---D--ILWSKKDKKHTEAWMTVFTTACLASVAVAILTVLKKPVLTTTAERAIIFLTICHAAVA
IGYVIRLAAGRNVACTSAISLHSQDQTQDGLANPYCAVVFLLLYYFGNAAIVWWVVICAWWCIMAR-KWTRTPQQGFSTIAAVAAWGLPAAHTIAVLVTR
-VDADELTASCFVGQQNTHSLLVLVLAPQFVYLSFGTTFLLVGLASLLLPRRPA----EIHRRQKQLLTRVGIFGWLYAALMICLASTSFYEWWGRETWL
RAP-EPS---------AP-RIPSRPLLQVFVLRLVVTLGAGVMTAAWIWWPEATSLCRR---------------
>tr|A0A0C9Q5Y9|A0A0C9Q5Y9_9HYME FZD4 protein OS=Fopius arisanus GN=FZD4 PE=4 SV=1
---------------------------------------------HGACEPIRIEMC-GLGYNVTTMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHL
FLCSVYAPMCTEKSSPIGPCRGLCEQVRARCYPVLQGFGFPWPAALNCSKFPPKNNQHMCMEGPGEPGPVNPIQAIGAGNGP------------------
-WGCSWYANSGK-YV-FL---N---RSGRCAAACDA---D--ILWSQREKRLFEVWMAAFTTICLISVAVAIFALLRNRTTLTIGENAIAFLTLCHTAVA
IGYVIRLAAGRTVACTPAIPLHPQDQTQDGLANPYCAIVFLLVYYFGNAASVWWVVLCTWWCIAAR-RWIRSLQQGFSTVGAVVAWGFPAAHTIAVLVTR
-VDADELTGSCFVGQQNSRSLLLLVLTPQLIYLLVGSTFLLSGIATLLLPHPSV----EVHRRQKSLLTRAGIFACVYALVMMCTTSVILYEWWGRDSWL
RAP-EPS---------TP-RMPSRPQLQYFVLKVIVSLSGGAAAAAWIWWPSLLTIWRR---------------
>tr|A0A026W7Q1|A0A026W7Q1_CERBI Frizzled-4 OS=Cerapachys biroi GN=X777_09049 PE=4 SV=1
---------------------------------------------HGACEPIRIEMC-GLGYNVTVMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHL
FLCSVYAPMCTEKPAPIGPCRGLCEQVRARCYPVLQGFGFPWPAALNCSKFPPENNQHMCMEGPGEPGPANPIQVSTNNGP-------------------
-WGCSWYAKSGL-YI-FL---N---RSGRCAAACDA---D--IMWSQKDKRLTEAWMAVFATVCLVSVAIAILMLLKKPVLITAPERAIVFLMLCHGTVA
VGYVIRLAAGRNVACTSATPLHPQEQTQDGLANPYCAVVFMLLYYFGNAAIVWWVVICAWWCIMAR-KWTRTLQQGFSTVAAVAAWGLPAAHTIAVLVTR
-VDADELTANCFVGQQNTRSLLVLVLVPQFLYLSFGMTFLLIGLASLMLLRRRT----EIHRRQKRLLTRVGIFSYLYAVLIICLTSTTFYEWWGRETWL
RAP-EPS---------AP-RVPARPLLQVFVLRLVMTLGAGVMSAAWIWWPEVTSVCRR---------------
>tr|E2AEJ0|E2AEJ0_CAMFO Frizzled-4 OS=Camponotus floridanus GN=EAG_05536 PE=4 SV=1
---------------------------------------------HGACEPIRIEMC-GLGYNVTVMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHL
FLCSVYAPMCTEKPAPIGPCRGLCEQVRARCFPVLQGFGFPWPAALNCSKFPPENNQHMCMEGPGEPGPANPIQAVSASNGP------------------
-WGCSWYAKSGL-YI-FL---N---RSGRCAAACDA---D--ILWSQKDKGLTEAWMVVFTTICLISIVIAILILLKKPVLTTAADRAIVFLTICHTIVA
IGYVIRLAAGRNVACTSAIPLHPQEQTQDGLANPYCAVVFLLLYYFGNAATVWWVVICAWWCIMAR-KWTKTLGQGFSTIAAVLAWGLPATHTIAVLVTR
-VDADELTANCFVGQQNTHSLLVLVLAPQFIYLSFGITFLLVGLASLTLPRRPI----EIHRRQKQLLIRVGIFTCLYAVLIICLVSITFYEWWGREMWL
RAP-EPS---------AP-RVPARPVLQLFILRLVLTLGAGVMASAWIWWPEITSICRK---------------
>tr|F4WXL7|F4WXL7_ACREC Frizzled-4 OS=Acromyrmex echinatior GN=G5I_10702 PE=4 SV=1
---------------------------------------------HGACEPIRIEMC-GLGYNVTVMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHL
FLCSVYAPMCTEKPAPIGPCRGLCEQVRARCYPVLQGFGFPWPAALNCSKFPPENNQHMCMEGPGEPGPANPIQAVSTSNGP------------------
-WGCSWYAKSGL-YI-FL---N---RSGRCAAACDA---D--ILWSQKDKKLAEAWMAVFVTVSLVSVAIAILTLLKKPILTSPAERAIVFLTICHAAVA
IGYVIRLAAGRNVACTPAIQLHPQEQTQDGLANPYCAVVFLLLYYFGNAAIVWWVVICAWWCIMAR-KWTRTLQQGFSTIATVAAWSLPAAHTIAVLVTR
-VDADELTASCFVGQQNAHSLLVLVLAPQFVYLSFGATFLLIGLATLVLPRRPT----EIHRRQKQLLTRVGIFGCLYAILIICLASTTFYEWWGRETWL
RAP-EPS---------AP-RVPARPLLQVFILRLVVTLGAGVMAAAWIWWPEVPNACRK---------------
>tr|E0VTY7|E0VTY7_PEDHC Class D atypical G-protein coupled receptor GPRfz3, putative OS=Pediculus humanus subsp. corporis GN=Phum_PHUM440660 PE=4 SV=1
-------------------------------------------QNLRTCEPIRVELCRGLGYNMTGMPNLVGHDLQGDADFTLQTFSPLIQYGCSGQLHF
FLCSVYVPMCTEK--PIGPCRGLCESVRSRCFPVLQGFGFPWPAALDCSKFPQENNEHMCMEGPGEKDMEINNAVAPTQPSPRNSLTS-------RNNVH
VAPCAKYS--KSNL-Y-V----YVNRSGRCAPLCDK---D--VLFTANDKKLAEVWLSVSAALCFLSSLLAVFTFLVDSGRFRYPERPLVFLALCYNLAS
VGWGVRAAAGRAVACHPD--PN----SQDGLG-ANCAVVFLLLYYFGNAASVWWVVLTVAWFLSGTKRWAHERIQQHSSLFHLAGWGLPAVQTIAVLVLR
-VDADELTGTCYVGNQRTRSLLVFVLVPQ-LYLILGASLLACGLLALSRRKPTIVRRDIIADKNEAVILRLGVFGVLYTIPAVCVVASLIYEYYFR-DWL
LST-ER----------T--RPQPKPSIWIFLLRIFMSLVVGVTSIIWVWSPKVMRAWKRLFRRL----------
>tr|D6WXE3|D6WXE3_TRICA Frizzled 4 OS=Tribolium castaneum GN=Fz4 PE=4 SV=1
-------------------------------------------PLVRTCEPIRVDMC-NLGYNMTEMPNLGGNDIQQEADYTLKSFSPLIQYGCSSQLKL
FLCSVYVPMCTEKANPIGPCRGLCESVRAKCYPVLKGFGFSWPDALNCSRFPVENNEHLCMEGPKDRGVDVL-APVDPA---------------------
---VQKFD-CGR-NF-VR---N---ELGNCVPACDT---N--LMFDDSEKNFAEVWVTVWAMICFVISLASALTLTIG----RVKARPLISIALCYCMVS
AGWALRMFSGRSPFCPP----------EDGLSNVNCAFVFLLIYYFGMAANAWWVCLCAWWVARVGLAWPPEKLRSLGSVLHVCAWGLPAAQTVAALVRR
-VDPDELTGTCYIGNRNSATLLGLVLIPDFIYFMLGIFFLILGCVRVIRKPRPS------PRKE---SDFLGAVCTLYAIPTFCVMASIYYEYNNRDQWL
NRE-------------------SKPALWAFLLRHLMSLFIGVSTIFWIWSMKTVTAWRA---------------
>tr|A0A067QI70|A0A067QI70_ZOONE Frizzled-4 (Fragment) OS=Zootermopsis nevadensis GN=L798_01936 PE=4 SV=1
-------------------------------------------TTLRTCEPIRVELCWGLGYNVTGMPNLVGHEIQGDADFTLQTFSPLIQYGCSAQLHF
FLCSVYVPMCTEK--PIGPCRGLCESVRARCYPVLQGFGFPWPAALNCSKFPLENNEHMCMEGPGEVGVGPRTGLVSSDAATPAISRIP----SVSRPSS
VAPCSRYV--RHNR-Y-V----YVNRTRRCNPLCDA---D--VLFENSDKYLAEVWLSVWAGLCFISSLVAVLTFLVDSGRFRYPERPLAFLALCYNLAS
VGWGVRAAAGRAVACSPD--TQ----SQDGHI-ANCAVVFLLLYYFGTAAAVWWVVLTMSWFLAAALRWTHERIQQHSSLFHLAGWGLPAAQTIAVLVLQ
-VDADELTGACYVGNQDSKSLLVFVLAPQ-LYLVLGASLLLVGFLALFRRRPRPAKVSAKAGKLEMVTVRLGVFGVLYTVPTTCVVASLFYEYWSR-EWL
MVS-SV----------P--RYQPRPSLWIFLLRLFMSLVVGVTAGVWVWSPKTLRAWRRLFNRL----------
>tr|U5EVX7|U5EVX7_9DIPT Putative frizzled 4 (Fragment) OS=Corethrella appendiculata PE=2 SV=1
-------------------------------------------ATQPRCEPIRIESC-GLGYNETSLPNLVGHELQTDADFTLQTFSPLIQYGCSAQLHF
FLCSAYVPMCTPKPVPIGPCRTLCETVRARCHPVLQGFGFPWPSALDCNRFPKENNEHMCMEGPGEPSGVSGFVNTGTSGNPLILSST-------KITTY
KPTCQTLIKSHL-YV-KL---N---RSGRCAALCEA---D--ILFEQNEKHTAEVWLISWSVVCLLTAIVATLCIVLT-----RWDKILMPLVISHCLVT
VGWAVRWLAGRATSCGYDPQL-----LTDGLSTAPCAANFLLRYYFGMSAATWWTILCYKWSTSVRRLLSENSENSYSTLLQLAAWGLPAIQTVIALVAK
-VDSDELFGSCLIGNQSDKALLTFLAIPLLTYWLIGSGYLFTAYLR----KRST------VNNLPPHLNGIGTFLTIYSVPSFLLLVLIFYEYASRENWL
NLP-HPS---------EP-VLATKPPIWCYILKVVIELLLGVLASAWIIAPRISKICRT---------------
>tr|Q16Z40|Q16Z40_AEDAE AAEL008322-PA (Fragment) OS=Aedes aegypti GN=GPRFZ4 PE=4 SV=2
-------------------------------------------ATQRTCEPIRIELC-GIGYNETSLPNLVGHELQTDADFTLQTFSPLIQYGCSKQLKF
FLCAAYVPMCTPKPMPIGPCRGLCLTVKTLCHPILQGFGFPWPSALDCNRFPEENNEHMCMQGPGEPTDGVVMISKNDRP--------------------
--TCQGLIKSHL-YV-RL---N---RSGRCAPLCEA---D--IMFEQNEKHFAEVWLTSWSVAALFTAIIATLCLILK-----RWDKILMPLVISHCLVT
VGWAVRWLAGRATACGYDTQL-----LTDGLMTAPCAATFLLRYYFGMSAAVWWAILCLRWSKSVRRLLNNDTESSYNTLFQLAAWGLPALQTVIVLVVR
-VDADELFGSCFIGNQSDRALLGFVVVPLLTYWVIGSGYLFTAYLR----KRSS------VNNLPVHINGMGKFLFIYSVPSFLMLVIMFYEFAYRENWL
SVP-HPS---------EP-VSSMKAPIWPFILRAVIELLVGVLASAWAVGPRIAGLCRS---------------
>tr|Q7PWS3|Q7PWS3_ANOGA AGAP008871-PA (Fragment) OS=Anopheles gambiae GN=GPRFZ4 PE=4 SV=1
-------------------------------------------STQRTCEPIRIELC-GIGYNETSLPNIVGHELQSDANFTLQTFFPLIQFGCSKQLKF
FLCATYVPMCTPKSMPIGPCRSLCNTVKNRCHPILQGFGFPWPSALDCNRFPEENNEHMCMQGPGEPAEGEVLVSDRPS---------------------
---CQGLQRSNL-YV-QL---N---RSGRCAPLCEA---D--IMFEQNEKHFAEVWLTSWSVAALGTAIVATLCLILK-----RWDKSLMPLVISHCLVT
VGWAVRWLAGRATACGYDPQL-----LTDGLSTAPCAATFLLRYYFGLSAAVWWAILCLRWSKSVRRLLGTDPNSSHDTLFQLAAWGIPAVLTVIVLVAR
-VDADELFGSCFIGNQSDKALLTFVIVPLLSSWVIGSGYLFTAYLR----KRSA------VHNLPVHIHGMGKFLFIYAVPSAALLMLMFYEYACRENWL
HLP-HPS---------DSPLHPSRAPLWPFLLRAFIELLVGVLASAWAVGPRIVGLCRG---------------
>tr|A0A085MXC6|A0A085MXC6_9BILA Uncharacterized protein OS=Trichuris suis GN=M513_12132 PE=4 SV=1
-------------------------------------------GGGGGCQHVEVSMC-DLPYNYTSVPNFVGNEEQSEAELQLSTFLPLIQLQCSSQLKF
FLCSVYVPMCTDKDIPIGPCRPLCESVRRCCEPMLRQFGFPWPASLNCSKFHPENNQAMCMRGPSEDHSSLCFGDTYPAAVAVEDSTTSIIGRRLSISNS
YGPCSHLRDGGRNFV-RL---N--KTGGQCAQLCHA---D--VLFSVEQKRNAEVLMLVFAAACSVLCVAALAFQ--KRVALHYPDVAILYICICYASAT
VPYWIRA-AGRALTCSGYGYHQ----AGFGLQHVRCTVVSISLYYFTMASHVWWIILCACWLLIGSLGFSAQSIQRQSFTFHCVAWILPLIKVIVVFIMQ
-VDADELTGMCFVGNQSRQG-LQFLLVPQTVYLVAGLVPLTLGFVIKLRDCLGGGN-A--QTPAGASLTSTGLLAAFYVVPHGCLLACYAYEYFNRDDWL
KYA------------------GKQPSYETFVVKIVAVFVYGIACGGFLLWRRTCDRSVLTRAPA----------
>tr|Q589S5|Q589S5_DUGJA Frizzled receptor OS=Dugesia japonica GN=DjfzA PE=2 SV=1
-------------------------------------------LRASRCEDLVMPLC-GLWYNRTRMPNMFNHETQEEAGHQAQQFMYLVTIKCSPDLHF
FLCSIYTPICVENDKPLPPCRSICQRSKDGCTPIMRNYGFSWPSQMSCDQFPEGSTKQLCMERDISSTTLAPVIMKPTPLIQVDDDDIINNSNVRCNCKC
RSPMIKIDSVHHAYY-NK---VYTGGIINCAWPCRS---P--F-IENNRYYLISLWLSISVGLIFICCISSLLTFFLNLELIQPPHRFVAYICCCQIGMS
IGFIIRLVAGHKTVCFQPDYKPIHESRFQNSAPSVCSISFLFTYFFFFASVLWWWLLCLTWFFSDGLGWSSSMIDKYSQLYHFIAWFFPGIFSMLALTMS
-VDGDPVTGLCLVGNINRQHLITFLLAPLCVFTCSGLFFLACGFLSVTKCDQSSSHRSPKITTSSITKCFYGFLGLICSIPLCLTTGSIVYEMRWRSHWE
VLT-TCSCLNE-----ESNSYLSTPSILLYILKYSGFFAIGIICGPWIWPMQTFNTWLEPIIHL----------
>tr|E5SHI7|E5SHI7_TRISP Uncharacterized protein OS=Trichinella spiralis GN=Tsp_03907 PE=4 SV=1
-------------------------------------------STTEKCTHDKELKCTKEVY-----PLIITNANT----SGYENFYRL--SHCWPYLKE
MLCSAMMAPCKNS---RLISESLCIETRDQCQFLIKH-G-RWPKILSNQDSKLYS--RDCKQSLQ-----PLFRHENIS---------------------
----TNRASCLLPLV-YS-EHRDQLHFPNCAFNCTS---H--WLKPQEHEELDSVVLFLAPIICTFLILTLIATVTG-VRRIPKDFYPLTWKIFCHAVIA
LVIAFRF-KFKLVSCNSDGSLRSK------DQKSICTLQFVCLYLSTLASSGWLTV-FFAFQLAETLPSSSDVYDKLINNVHFALWGPCLLLVITVISSM
-YGPDGINGMCYFGVDDPMNNFYLVYLPTGIALIMTTTFFIITIARRHHISRAANTV-------GFSTAKLGILFTTNLLLYVTDLGLHIYDMSMF-YKR
NAALLFRCQLDSLHCKL--M-HTLNIALVKVGFLVQFLFPGLIDCAFLWQSRYELDWLQ---------------
>tr|F6VWI5|F6VWI5_CALJA Uncharacterized protein (Fragment) OS=Callithrix jacchus GN=FZD8 PE=4 SV=1
-------------------------------------------AKELTCQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCERLPEQGNDTLCMDYNRTDLTEPGCQCRAPMVSVSS---------------E
RHPLYNRV--------------KTGQIANCALPCHN--PFF----SQDERAFV-FWIGLWSVLCFVSTFPTVSTFLIDMERFKYPERPIIFLSACYLFLS
VGYLVRLVAGHYEELGAVE-------RYKT--TALCSVVFLLVYFLVMASSIWWVILSLTWFLEAGMKWGNETIAGYSQYFHLATWLVPNI-SIAVLALN
-VDGDPVAGICYLVNHSLYNLRGLVLAPL-IYLFMYIKILLTIFALLLSIFFFFKHQVTIKHNR-----IKGLKQVIYTNKKEEVVEYIFIEQHNR-RWE
AT--CP-CLRD-----LQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRC----------
>tr|F1PHW9|F1PHW9_CANLF Uncharacterized protein OS=Canis lupus familiaris GN=FZD8 PE=4 SV=2
-------------------------------------------AKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNDTLCMDYNRTDLTTAAPSPPRRLPPPPPPPPGEQPSGHGRPPGA
RPPSRDRI-------DSW----DASEVVDAAPPRLGGPPGF-GKFGILSKNFQTHQAGYFLLFFFNEPLYAEKHFLPTFVL-----ETLNSIGIQFKGLR
ITVLANSAENDYSKVQRLE-------VFER--PD--NETRRLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALS
-VDGDPVAGICYVGNQSLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRSVIKQQGTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNR-RWE
AT--CP-CLRD-----LQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRC----------
>sp|Q498S8|FZD8_RAT Frizzled-8 OS=Rattus norvegicus GN=Fzd8 PE=2 SV=1
-------------------------------------------AKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYTPICLED-KPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNDTLCMDYNRTDLTTAAP-SPPRRLPPPQPGEQPPSCEPGCQCRA
PMVSVSSE----HPLYNRG------QIANCALPCHN------PFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVS
VGYLVRLVAGHKVACSGGAPGAGGAGRYET--TALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALS
-VDGDPVAGICYVGNQSLDNLRGFVLAPL-IYLFIGTMFLLAGFVSLFRIRSVIKQQGTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNR-RWE
ATH-NCPCLRD-----P--DQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTR-----------
>tr|U5IMJ5|U5IMJ5_9CNID Frizzled 4/9/10 OS=Ectopleura larynx PE=2 SV=1
-------------------------------------------QNPWRCVPVEVPMC-GIRYNMTIDPNYIDKTTQTEIAVELHPYINLLHTNCSEHLRL
FLCSVYVPYCNVEDQPITACRPLCEEVKSKCLRLMEKFNFSWPERLQCHRFPEMGSNQLCSNGPLNATTISRRTKTTKTPTQTRQKTAVVKTMSTQKPYS
KICNNLFVRNSGNYV-FV---R---RIVSCVLECNK---D--GLFTFEQKESMEKWISALSCCCCLLCFLAMFVTF-GYKKTLYPQRTILFITISYVFYS
IAHIVRIVSSRAVSCQEE--------IWDGSGNIPCAATFLFIYCSYMAQNIWWVILTLTWFLCSGLKWKQATIQSKSFYFHLVAWGVPCAKTLVIFVAR
-IDVNELTGMCTIGNRYESSLSGFVLGPLFTYLITGTIFLIFGVLVLFKLPANTLK--SV--KIELRSASDALYATLHAALSIFVLSSYFYEYFEKYAWY
NDP-----------------NSSGPNYNIFLMRVIAVFAIGICAALLLISLHLPAFYKHLKAKL----------
>tr|A1IKD5|A1IKD5_HYDVU Frizzled4/9/10 OS=Hydra vulgaris GN=hyfzd4/9/10 PE=2 SV=1
-------------------------------------------HNTWKCVPIRLDFC-DVAYNETINSNYTDKTNQDEIKSELSHFTLLLRTGCSVHLRL
LLCSAYLPYCSPKEKPITACRPLCEEVKRKCLKHMDTFDFGWPSSLECSKFPKKNSESLCLNGGLTSLNATKEISEKSVLSTKSKFSKIDETSSKEIDNH
IPCSLGYSRNSKNYF-FS---Q---KTKTCVLDCFK---N--GLFSSEEKDSVEKWMSALSSCCCLICSVALVVSL-VYKRVLYPEKAVVFITVCFVFYS
IGHIIRIVYTRNISCGEE--------LRDGSTNVACSSIFVLSYGFFMAQNIWWVILTITWFLNSGLKWKKQTLTKNVKYFHVVAWGIPCAKTLVILVLR
-IDGNELTGMCSIGNHHESSLSGFVLGPLFTYLLTGTIFLLFGKVVSFKLLSSSSD--KTF-LFKQENNSVGPLAVSHALFSAYILSMYFYEYFNKTLWL
NDV-----------------YLERPNFYLFLLRIIFEFMIGITAAAWLLILYLPGFCKKLLRKI----------
>tr|I1YAR6|I1YAR6_9CNID SFRP (Secreted Frizzled related protein) OS=Clytia hemisphaerica PE=2 SV=1
-------------------------------------------GSSWKCVPVKLDFC-GIGYNETIVPNRTNKNSQEESLSELKIYELLQRTQCSSKLRL
LLCSVYLPFCHANEKGIVACRPLCEEVKSKCQKHIEEFNLKWPDVLNCEKFPVENVPDFCVPGNRHSSTEVPPTSLKTKKTPKRIIPQTVTRATGLISKE
KYCQVVYSRNVKNYI-YV---E---KIQSCALECMK---D--GIFTTQQKQLAERWISALTCICGILSVAAILCVL-AYNETCFPERTIFFIAVCYFFYV
VGYMIRIVYSRGVTCQKE--------LVDGSGNISCAATFLLVYCFSMVQSIWWVILCLTWFLSAGMRWATEAIRSKSFMFHSLAWGIPCCKTVIVLVWR
-IDVNELTGICSIGNRYERALRWLILGPLFVYLIMATMFLLFGLICLFRLPDPNEN--MERKKNQYLLLPIGSYAALHTLFMTFILASYFYEYVNKGPWY
NDP-----------------KSTGPSFAVFLTRIISDFSIGISASIWLLLIHGPRLHRRMKVKL----------
>tr|Q9W6E2|Q9W6E2_DANRE Frizzled protein OS=Danio rerio GN=fzd5 PE=2 SV=1
-------------------------------------------SKDIVCEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLF
FLCSMYTPICLQD-KPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDDRLCMDRNSSETTTLSP-PFPKPTPKGTPRHRATACDRECHCRG
PLVPIKKE----HPLHNRG------SLPNCALPCHQ------PYFSQDERTFTTFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLAACYLFVS
LGYIVRLLAGHRVACEGT--------LYDT--TALCTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALS
-VDGDPVAGICYVGNQSLEGLRGFVLAPL-VYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYS-SWE
RAL-ACSCPSE-----R---LGMGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFIARY----------
>tr|A0A060YSX9|A0A060YSX9_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00059610001 PE=4 SV=1
-------------------------------------------SKDIVCEPITVPMCKGIGYNLTYMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLF
FLCSMYTPICLQD-KPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPQLGDETLCMDQNSSETTTLAP-SFPKPTPKGTRRRQPAPCDRDCRCRD
PLVPIKKD----HPLYNRG------PVDNCAQPCHH------PYFSQDERTFTTFWIGLWSILCFVSTLTTVATFLIDMERFQYPERPIIFLAACYLFVS
LGYIIRLVAGHRVACAGS--------LYDT--TPLCTLVFLLIYFFSMASSIWWVVLSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLIPSVKSIAVLALS
-VDGDPVVGICYVGNQSLESLRGFVLAPL-VYLFTGSLFLLAGFVSLFRIRSIIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYR-GWD
RAL-SCSCQAE-----R---LGLGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFTARC----------
>tr|T1KGR8|T1KGR8_TETUR Uncharacterized protein OS=Tetranychus urticae PE=4 SV=1
-------------------------------------------VTKKRCETVSVAFCREIGYNETIFPNLLNHNSQQNAGLALHRITPLIKVNCSPDLKL
LLCAVFFPPCT-IEAPIPPCRSICLSSKNGCEDVIHRFGQEWPSYLDCDKFPDV-E--PCVSRTGSRIASESSLTPTSASTGVNYAPTAP---FRFVCPV
HFMVPKGE----GYILRL----NGRIYHDCATPCDG------LLFNSSDRKLIRAEIIILAIICLVSSLFTLFTHLLESRRFSYPEKILKFLAISYTAIA
LIHIIGFVFGDRISCNEPPPVSVSNPITQGNS-SVCSLTFMALYIFSHSSFIWFTIMTFTWFIAFCFGWGREAFERISIWFHVFAWGIPSLDAIRILAMK
-IEGDPLSGVCYHNFWNREDYQHYTDSFL--YISLSILFLAIGFYFSFRLRRELRDDA--TYKMDTLLWRVSIFSVFYLVSSFISIACNVYEVSHL-SWM
LD--QTVCLR-I-PCPFQEEVPKKPNLHYFVLKYAARLVPGISLSFHLFSRKTLDSWLDFNRKL----------
>tr|H2LH10|H2LH10_ORYLA Uncharacterized protein OS=Oryzias latipes GN=fzd2 PE=4 SV=1
-------------------------------------------PPHGFCQQISIPLCTDIAYNQTIMPNLMGNHNQEDAGLEVHQFFPLVKVQCSPELKF
FLCSMYAPVCTVL-KPIPPCRPICEKRQ-GCEALMNKFGFQWPEKLRCENFPLLGDGQICVGQNESSSPTA---PPPLPPAPGTRELPRVSERPFTCPSV
LRVPPYLN-----Y--------HFLEEKDCGAPCESPNGGN-MFFSDKEIHFARMWVLIWSVLCCTSTFFTVTTYLIDMQRFRYPERPIIFLSGCYTMVS
IAFIAGYFLG-KVAC-NDSFNP----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMG
-IEGDVLSGVCFVSLSNLDPLRGFVLAPL-IYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEQLMVRIGVFSVLYTVPATIVIACFFYEQAFR-HWE
RSW-SRNCRSL-IPCPAQSRPHMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|A0A0B5CS95|A0A0B5CS95_TRIAD Frizzled A OS=Trichoplax adhaerens PE=2 SV=1
-------------------------------------------TVKGNCQILQSNLCSGLQYNQTFFPNYFNHKDQSISQTEMDVYRPMIVNNCSPVIRQ
FLCSLYMPKCISPTKPIPPCRPLCIRARDDCKKFLSNFGLTWSDSFKCENFPPVNAL-VCINENFTIVQSVSSRPPSVNTSTSPST-----------RAC
GILQNQKS----EY--------TFLNIPGCAKPCHD------FYFNSNQIQLASSVVGIVAILAFCCTLLIFITFLIDRQGYEYPERSVIFLVFCYCVLS
LTYIVGFMAQRNIACNPSTQS-----VHQGSG-EGCTVLFLINYFFTIASSVWWVVFSLGWYLAAGKKWVEEGINAVSHYFHLAAWLIPAILTIVVLALG
-IEGDVLSGICFVN-TRSNYLYGFVIAPL-IFLLIGLGFSIATLISFYRIRREMLTDH-GTAEFEKLLKKIGIFAFLYVVPGIIVISCYLYEASNQ-SWT
AY--QQNCRRY---CSSTSIPANAPNLAIFIVKYIALFSFGIASSYWIGLQRAVTAWKLCYRRL----------
>tr|K1PBI6|K1PBI6_CRAGI Frizzled-5 OS=Crassostrea gigas GN=CGI_10010787 PE=4 SV=1
-------------------------------------------EEERRCQEITIPMCKGIGYNLTHMPNQFHHETQEEAGLEVHQFWPLVEIHCSPDLKL
FLCSMYTPICIPD-YPLPACRSVCERAKSGCAPLMALYGFEWPERMKCENLPVFGSGQLCMDHNQTETTASPTKKDHHVKPKEPNNPNIHKPVQNRHCDC
KCRMINLD----FY-NKI----STGGFENCAVNCTS--PYF----TPDEMTFATFWVGLWSILCCISTSMTILTFLVDTERFKYPERPIVFLSVCYFMVS
VGYIIRLIAGHAVACHKN--------YE-TT--ALCTVVFLLVYFFGMASSIWWVILSFTWFLSAGLKWGQEAIASYSQYFHLAAWLIPSVKSIIVLAKS
-VDGDAISGICSVGNQNSDNLKWFVVAPL-VYLIIGTSFLVAGFVSLFRIRNVIKQQ-TTTDKLEKLMIRIGVFSVLYTVPATIVIGCYIYELTLK-KWE
RS--CP-CEG----------DESKPDYSVFMLKYFMCLVVGITSGFWIWTGKTVDSWKKLFNGP----------
>tr|W5LU60|W5LU60_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIQYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKF
FLCSMYAPVCTVL-QAIPPCRSLCERRH-GCEALMNKFGFQWPERLRCEAFPVHGAGEICVGQNTSDPG----SPTSEPTLYAPGLTPPPGGQPFTCPLQ
LAVPSYLN-----Y--------KFLGAKDCGAPCEHSPHGL-MYFREEEMKFGRLWVGIWAILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVA
VAYVTGFLLE-KVVC-IDKFRE----VAQGTK-EGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILALG
-VDGDLLTGVCFVGIYNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR-QWE
KTW-MQTCKRF-VPCPSSNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL----------
>tr|H3CZ50|H3CZ50_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
-------------------------------------------AGRGSCQPISIPLCTHIAYNQTIMPNLLGHRGQDEAGLEVHQFYPLVEVRCSSELRF
FLCSLYAPVCTLL-RAIPPCRSLCQRARRGCEALMNSFGFQWPEKLRCQNFPEDGGGRICVGPAPDRPPAPGPGTAHVQTNQSFQ------------CPV
QLRVPPHL----KYRFL--------GAADCGAPCEPSPHGL-LHLAAEDLRLARLWVGGCSGLCGASSLLSLLTFLLARRRLAYPERPLLFLSGCYLMVA
AAYVSGFLLE-RAACVDAFSPAS---VVQGTR-EGCTLLFVLLYFFGMAGSVWWVVLALGWFLSAALKWSPEAIAGRSAYFHLAAWAVPALQTATVLATG
-VDGDLLTGVCYVGVSSVDALRTFVLAPL-VCLLAGTSLLLAGFVSLFRIRAIMKRDGD-TEKLEKLMVRVGVLGVSHTLPAAVVVACCFYEQTFR-RWD
TS--LRACRS-V-PCPAGDVAPATPDLTVFVLKYLMTMMVGITPGFWICSEKTPKAWRSF--------------
>tr|K7BSB9|K7BSB9_PANTR Frizzled homolog 1 OS=Pan troglodytes GN=FZD1 PE=2 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTAFPFSCPRQ
LKVPPYLG-----Y--------RFLGERDCGAPCEPGANGL-MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAHVAGFLLE-RAVC-VERFSD----VAQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-IDGDLLSGVCFVGLNSLDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVLACYFYEQAFR-HWE
RSW-SQHCKSL-IPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|W5LQU3|W5LQU3_ASTMX Uncharacterized protein OS=Astyanax mexicanus GN=FZD7 (1 of 2) PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKF
FLCSMYAPVCTVL-QAIPPCRSLCERRH-GCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSEAAGGGAGATSEPTGYGREPLTLPPSPHFTCPLQ
LRVPSYLN-----Y--------HFMGEKDCGAPCEPTPNGL-MYFREEEVKFGRLWVGIWSVLCCASTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVA
VAYAAGFFLE-RVVC-IDRFSD----VAQGTK-EGCTILFMILYFFGMASSIWWVVLSLTWFLSAGMKWGHEAIEANAQYFHLAAWAVPAVKTITILALG
-VDGDVLAGVCYVGVHSVDALRGFVLAPL-VYLFLGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATVVIACYFYEQAFR-QWE
RTW-MHTCKRF-VPCPAGDFAPVTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL----------
>tr|I3JSE2|I3JSE2_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100710446 PE=4 SV=1
-------------------------------------------PEHGFCQPISIPLCTDIAYNQTIMPNLLGHTTQEDAGLEVHQFYPLVKVQCSLDLKF
FLCSMYAPVCTVL-QAIPPCRSLCERRQ-GCEALMNKFGFQWPERLRCENFPIHGAGEICVGQNTTETE----GPTSDPTPSLSELVTFPPNQPFFCPLQ
LQVPSYLN-----Y--------HFLGVKDCGSPCEPSPNGL-MYFQEDELKFGRLWVGTWSILCCVSTLFTVLTYLVDMKRFRYPERPIIFLSGCYFMVA
VAYSAGFLLE-RVVC-VDRFKE----VAQGTK-EGCTILFMILYFFGMASSVWWVVLSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMG
-VDGDLLTGVCYVGIYNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVIACHFYEQAFR-QWE
VTW-MQTCKHF-VPCPASNFASNTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLQSWRRFYQRL----------
>tr|X1WJC0|X1WJC0_ACYPI Uncharacterized protein OS=Acyrthosiphon pisum PE=4 SV=1
-------------------------------------------GHHGRCEPITIPFCMGIAYNETIMPNILGQMRQDEAGFEVQQYYPLVKIQCSHDLQF
FLCSVFAPVCTII-KPIPPCRSLCVSARNGCEAIMNRFQIEWPDNLECNQFPENGQ--LCVGENNATNPSPTPQTGLIEQNGKDLTAPGSRGFVCPQQFR
IESNSNKK----VYTLKV----NK-VVKDCGVPCDA----F--W-SLDQMRKARSWVALWSVLCAISCLFTSLTFAIDTHRFRYPERPIIFLSLCYLMVS
ISYLIGYLSG-NIACNKQ--------ITQGTD-EWCTVLFMVSYFFSTASSVWWVVLTLTWFLAAGLKWGHEAIEANSHYFHLAAWTVPAAKTITVLAMG
-IEGDVLTGICSMAVWSDDAVRDMVLIPL-VYLILGTAFWMAGFVSLCRIRKVMKHDGRGTDKLEKLMIRIGVFSVLYTVPAVAQILCLVYEHVNL-SWI
IS--STLCQD-L-PCPSQNDTGRKPSFEVFIAKYFVSLLVGLTSSVWIWSGKTVNSWQKFLARI----------
>tr|A0A067QHH7|A0A067QHH7_ZOONE Frizzled-7 (Fragment) OS=Zootermopsis nevadensis GN=L798_02316 PE=4 SV=1
-------------------------------------------PHHNRCEPITIPFCMDIQYNETIMPNLLNHQKQEDAGLEVHQYFPLVKVKCSPDLQF
FLCSIYAPVCTILDKAIPPCRSLCVSARHGCEELMNNFGFQWPEELDCAKFPETGI-DICVGENNTASTNVPG-GGSRTGGPIAHGDNYPFRDYGFVCPV
HFKVPKDM----DYSLKV----GDKVEKNCGAPCHG------MFFSDDERHFARVWVGVWSVLCAASCLFTVLTFLIDTDRFRYPERPIIFLSVCYLMVA
LAYVVGF--G-SIACRDPFPAPL---ITQGTK-QWCTILFMILYFFSMASSIWWVVLTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-VEGDILSGVCNVGLWDVDALRGFVVAPL-VYLVLGTVFLLAGFVSLFRIRTVMKHDG-KTDKLEKLMIRIGVFSVLYTVPALIVLACLFYEQAYF-HWM
LT--MEICSRPSIPCPVGRDFGRKPDFEVFMIKYLMALIVGITSSFWIWSGKTFTSWKEFFHKI----------
>tr|A0A0K8S350|A0A0K8S350_LYGHE Uncharacterized protein OS=Lygus hesperus PE=4 SV=1
-------------------------------------------PHHGRCEPITVPFCKEIPYNDTIMPNLLNHVKQEDAGLDVHQFFPLVKIKCNPELQF
FLCSVYVPVCTIL-RPIPPCRSLCLSARRGCDEVMLRFGFPWPEALECSNFPD--PPDICVGENTTAPPTTQQRPFVSKPPGSPGRPAHEAMDLGFVCPV
QFKVPKGF----DYTLKV----DK-VVKDCAAPCQG----M--FFTSQQINFSRLWVGSWSALCLLSCLFTVLTFMIDTERFRYPERPIVFLSLCYLMVA
ASYLAGASSG-TAACRKPFPPPL--DVTQGTK-EPCTILFMLLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPALKTITILAMG
-VEGDILTGVCYVGMMNPETLRSFVLIPL-VYLVLGTIFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGVFSVMYTVPALVVLACLFYEQAYM-SWM
LT--QEMCSKPI-PCPIGRGLGQRPEFEVFMIKYLMYLVVGLTSSLWVWSPKTLASWKGFFHRP----------
>tr|A0A0L7QLS8|A0A0L7QLS8_9HYME Frizzled OS=Habropoda laboriosa GN=WH47_11345 PE=4 SV=1
-------------------------------------------AHHGRCEPITINLCMNIPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPVLRF
FLCTVYAPVCTII-RAIPPCRSLCESARAGCERLMNSFDFAWPDNLDCSKLPENGGPELCVGHNETTP-PEPSPPAYSPPLMPVAEFQPSWRDFGFVCPM
HFKVPQEL----GYSLKV----DK-VEPNCGAPCDG----M--FFTERERRFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVA
LAYVIGWAAG-SISCREPFPPPL--DITQGTK-ELCTVLFMILYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMG
-VEGDILSGVCYVGLWNVEALRGFVLAPL-VYLVLGTAFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYF-QWM
LT--MEMCSRPM-PCPVGRDVGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFNHI----------
>tr|A0A026WRU5|A0A026WRU5_CERBI Frizzled-7 OS=Cerapachys biroi GN=X777_14916 PE=4 SV=1
-------------------------------------------AHHGRCEPISINLCMDIPYNETIMPNLMNHQKQEDAGQEVHQYAPLVKMKCSPDLQF
FLCTVYAPVCTII-KAIPPCRSLCESARSGCEGLMNSFGFAWPEALDCAKMPENDGKQLCVGTNETTTPQEPAAPVYPPPRIPVAEFQPSWRDFGFVCPV
HFKVPHGL----GYSLKV----DK-VEQDCGAPCDG----M--FFTERERRFSRVWVGTWASICAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVA
LVYVIGWVSG-SIACREPFPPPI--GIAQGTK-ELCTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIETNSQYFHLAAWAAPAVKTVTILAMG
-VEGDILSGVCYVGLWNVEALRGFVLAPL-VYLLLGTVFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYF-QWM
LT--MEMCSRPL-PCPVGRDLGHRPEFEVFMIKYLMAMIVGITSSFWVWSKKTLTSWQQFFHHI----------
>tr|A0A023F262|A0A023F262_TRIIF Putative smoothened (Fragment) OS=Triatoma infestans PE=2 SV=1
-------------------------------------------PDHGKCEPITVPICKKIQYNVTIMPNLLNHNTQEDAALEVHQFYPLVKIDCNSVLLF
FLCSVYVPVCTIL-RPIPPCRSLCISARSGCEEVLNKFGFPWPENLECDRFPD--PPDICVGENNTTSSTTSSSTKYKPVKQPTQQHYPSGMDYGFVCPV
QFKVPKGM----DYQLKV----DK-TVKDCGAPCDG----M--FFTEDQRKFARIWVGVWSILCAASCLFTVLTFMIDTDRFRYPERPIIFLSLCYLMVA
SAYIVGFGSS-TIACRKPFQSPV--DITQGTK-EPCTILFMILYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-VEGDILTGVCYVGLWNVETLRSFVLAPL-VYLVLGTVFLLAGFVSLFRIRTVMKHDGK-TDKLEKLMIRIGVFSVMYTVPALVVLACLFYEQAYM-HWM
LT--MEMCSRPI-PCPVGKDLGRKPDFEVFMIKYLMALVVGITSSFWIWSGKTFNSWKEFFYRL----------
>tr|A0A068CRI9|A0A068CRI9_HOFMI Frizzled-5 (Fragment) OS=Hofstenia miamia PE=2 SV=1
-------------------------------------------TAARECTPMRPNFCPFLPYSDTISTNIFGPPSEEV---KLRLLDTYKNIPCKNIAKF
VICTLFYPACF-PQQVLYPCIENCQEAVAHCSPTLIKLGYAWPEELKCEKHNLKSNHTSLIDGE----------QLCLNMPEAFRNNDPLPEPPKPGCPK
PIRTHAGL----GY--------NFRNVKNCGKPCDL------QL-EKSYYDFLHYWIGAWSGLCCIATIITVATFLLDMDRFRYPERPIIFIAGCYILIS
ACYLLGFIFGNKHSCSSS-------DVIHGEK-VACTLMFVALYFFTMASNIWWVVLSITWFLSAGLKWGHEAIEAKSMMFHAFAWAVPSVQTIAVVFVG
-IDGDELSGTCYTGLSNPVHMQLFVLIPT-AYLAIGVFFLLAGFVALCKIRTIIKDSG-KTKKLEMLMIRIGIFSIFYLIPACGLLACHMYELRYR-KIN
DS--SKICGTNEECVPVQDESFTAPNFNVLLARYFTSLVVGITSGFWIWSHKTIIAWHNALIRV----------
>sp|Q9I9M5|FZD1_XENLA Frizzled-1 OS=Xenopus laevis GN=fzd1 PE=2 SV=1
-------------------------------------------PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSIYAPVCTVL-QALPPCRSLCDRRQ-GCEALMNKFGFQWPESLRCEKFPINGAGELCVGQNTTESGTPTPAVPETWTSNSRTYYRD----KFMCPRA
LKVPAYVN-----Y--------HFLGEKDCGAPCEVGVHGL-MYFAPEELNFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVA
IAYIAGFLLE-KVVC-NERFAE----VAQGTK-EGCTFLFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVG
-VDGDTLSGVCFVGINNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
KSW-SQSCKTY-IPCPSTGHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|T1FSL1|T1FSL1_HELRO Uncharacterized protein OS=Helobdella robusta GN=HELRODRAFT_191092 PE=4 SV=1
-------------------------------------------PTHGKCEPITIEQCKNLEYNETIMPNVLNQMKQSDAKESITQYSRLIQSRCSQYIQI
FLCSVFVPVCT-QETALPPCRSLCLNSKLDCESVMKAAGYGWPEELDCKKFPDDNVV-LCVSVNGSEKDSSKEGRKNKNWPNKGSRGGNDGGPKELYCPT
FMRADSKS----DYRLFI----GDSVMKSCGMPCGVKDM----FSLSDKRKLVRLIICIVACICLLSSLFTFLTFLVDTRRFRYPERPIVFISACYCVIA
IAYIVAYALDNKISCSEFVEHF-DDDITQGTK-EGCTIIFVMLYFSTLASCIWWVILTLTWFLSAGLKWGQEAVESRSQYFHLLAWAVPGVMTIVLLAMG
-VDGDALTGICNTGLTNKEIATAFVAGPL-ILLSVGIFFLLAGFISLCRVRNAMKFDG--TDKLEKLMVRIGVYALLYVVPVAFVVGCVFYEHAWR-EWV
KG--HQTCSDLN-VFELDNYAGSKPDLTIFVLKHLMTLIVGVACGFWVCSGKTAESWSKFFCRS----------
>tr|A0A0B5CM76|A0A0B5CM76_OSCLO Frizzled A1 OS=Oscarella lobularis PE=2 SV=1
-------------------------------------------REDVKCVRIPLKKCLILQYNYTAFPNLLQQRRAQEAQRDFDVTSRLLSTGCSDFMIF
FVCSMYAPFCQVDDRVLPPCRNMCESARRGCEGLMRRYRFTWPDEFDCERLPEWDGSDKCAGVNDTELAKAAKQLRDRNRGFAPTVDLPTFIETTGRTAD
DLCPQPLR--VND--Y------TFGGHKGCGFPCPPIPDN--WYFLNERDEFAPNWIFAWALLCTFATFATILTFLIDRERFNYPERPIILLAFCYFVIA
VIYLTGYQKGSHVACNNRIGF-----QKMNSE-ISCAVQFLVLYLFTIASALWWVILTLTWYLAAVLAWGTEAINRLSQYFHLCAWAIPAILTIVVLALQ
-VDGDYLSGVCFVGVRDLASHNIFVVAPL-ICLLVGTFFLLAGFYSMFRIRSKVNLPMKDKTRLEKFMARIGIFSIMYTVPAAIVTACLIYESTNR-SWE
TTQ-LACA-------SRACLQGARPSFVVFMIKYFMLLLVGTTSGFWIWSRKTLESWKMFLFRC----------
>sp|Q08464|FZD2_RAT Frizzled-2 OS=Rattus norvegicus GN=Fzd2 PE=1 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTVL-QAIPPCRSICERRQ-GCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGTPALLTTAPPSGLQPGAGGTPGEHPFHCPRV
LKVPSYLS-----Y--------KFLGERDCAAPCEPAPDGS-MFFSHHHTRFARLWILTWSVLCCASTFFTVTTSLVAMQRFRYPERPIIFLSGCYTMVS
VAYIAGFVLQ-RVVC-NERFSE----VGQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHAAIEANSQYFHLAAWAVPAVKTITILAMG
-IDGDLLSGVCFVGLNRLDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEPLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR-HWE
RSW-SQHCKSL-IPCPAHYTPRTSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|F2X0X3|F2X0X3_9BILA Frizzled receptor 1/2/7 OS=Ptychodera flava GN=fz1/2/7 PE=2 SV=1
-------------------------------------------PHHGRCEPISIPLCQDIAYNETIMPNLLNHQKQDEAGLEVHQFFPLVKVECSVDLKF
FLCAVYAPVCTVLETPLPPCRSLCQSAKNGCEALMNRFGFQWPERLDCNTFPVHGSGPLCVGQNRS--VPTAMPTTKPDNKSVTPSSDTV--VPPFTCPD
ELRVPAYL----DYNFLD--------ADACGAPCDS------MFFSETQREFARIWIGIWSILCAASTLFTVSTFLIDMPRFRYPERPIIFYLRVIFMVS
LTYVVGFIID-EIACN----------AVQGTK-EGCTILFMILYFFSMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWSVPAVKTIAILAMS
-VDGDVLAGVCFVGFTNVDALRGFVLAPL-LYLLIGTSFLLAGFVALYRIRTFMKHDG-KTDKLEKLMIRIGIFSVLYTVPATIVIACFFYEQANR-LWE
YS--VNNCKK-HFSCPHGPMGLATPDFTVFMIKYLMLLIVGITSGFWIWSGKTLNSWRKFYMRL----------
>tr|A7SKM6|A7SKM6_NEMVE Predicted protein OS=Nematostella vectensis GN=v1g171640 PE=4 SV=1
-------------------------------------------LPLKRCEPVTIPLCTGLQYNMTIFPNTLKHRTQEEAALEVHQFFPLVKVDCSKDLAF
FLCSVYAPVCTVL-TPLPPCRSLCLTVRSGCEGLMKRFGFTWPDSLSCERFPKLGD-EICVGENTTTPTSDQDGGINNNTYPDVDMSTM-----RYRCPE
SQKIPNDQ-----YTFH--------GEKRCAATCRN----V--FFTKREREIARMWTGIWAILCAVSTLFTILTFLIDMRRFRYPERPIIFLSGCYFMVS
IAFITGYVAG-KIACNEPIKKGF--PLVQGTK-EGCTVIFMMLYFFSMASSIWWVILTVTWFLAAGLKWGQEAIEANSQFFHLAAWAIPAVKTIAILLMT
-VDGDELSGVCYVGLSDVSALRGYVLAPL-VYFIIGATFLLAGFISLFRVRSVLKDDYK-REKIEKLMIRIGVFSILYTVPALVVIGCLYYEQSNR-LWD
NS--EGWCTEVV-SCPPYPVPLQKPDFMVFMVKYLMFLIVGITSGFWIWSSKTLNSWRRFYRRF----------
>tr|H3AZ03|H3AZ03_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD1 PE=4 SV=1
-------------------------------------------PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSLELKF
FLCSMYAPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPDSLKCEKFPVHGGSELCVGQNTSERNPAVFSTPSESYPGTINPPKYPKRDKFVCPRA
LKVPTYLN-----Y--------HFLKEKDCGAPCESSPNGL-MYFSQEELKFSRIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVA
IAYIAGFLLE-KVVC-NDKFGE----VAQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVG
-VDGDVLSGVCFVGLNNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFR-QWE
KSW-TQTCKSY-IPCPSNSHPPMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|G0MFK4|G0MFK4_CAEBE Putative uncharacterized protein OS=Caenorhabditis brenneri GN=CAEBREN_12860 PE=4 SV=1
-------------------------------------------SAKRGCEQITIPMCKNLDYNQTVFPNLLGHTTQDEANPAISQFNPLIKVKCSEDIRL
FLCTVYAPVCT-VDKPIQPCRELCLSAKNGCESLMKKFGFQWPEQLDCNKFPVT-D--LCVGKNSSDSSSSK--KSSSDVTFGVSTIANEVVLSPKKCPH
VMRTTTGS----HFSLPL----LSGRLPECSLTCEADQVP--MMFDARIRRYLRICTAAWAVACFVCSLFTMVTFLVDLSRFAYPVRPILYLAFCYLAVS
LVYMIGVVGEDGFACGAYGST-----VTQGGE-VGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHALCWGFPAVLSVIVLVTN
-IDGDVFTGICSVGNLNPSALVYFFFAPI-VSLVLGGVLLACGIWSMCRIRNYIKLQHRNISKLEKLMFRIGAFAVLYAVPNAMNAAIMWYQAVNM-AWL
EG--HFRCMRHF-TYPTDDPKVASPEIIVFHLKYISQLVVGITCAIWVISSKTVSSYQKAYLAL----------
>tr|A0A0K3AWM6|A0A0K3AWM6_CAEEL More Of MS OS=Caenorhabditis elegans GN=mom-5 PE=1 SV=1
-------------------------------------------STTRKCEHITIPMCKNLDYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRL
FLCTVYAPVCT-VEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPVT-D--LCVGKNSSESSNSKNYRSSNDVTFGVSTIANEVVLSPKKCPH
HMHTTSGS----HFSLPL----LSGRLPECSLTCEADQVP--MMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAIS
TVYMIGVVGEDGFACGTYGST-----VTQGGE-VGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTN
-VDGDVFTGICSVGNLNPSALVYFFFTPI-VSLALGAVLLVCGIWSMIRIRSYIKLQHRNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNM-AWL
EG--HHRCVRLF-TYPVDDPKVAAPEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLAL----------
>tr|A0A0D8Y519|A0A0D8Y519_DICVI Fz domain protein OS=Dictyocaulus viviparus GN=DICVIV_02771 PE=4 SV=1
-------------------------------------------PSNQKCVPLKISMCIDVPYNTTVYPNLLNHQSQDDAEIAINQYHPLVKVKCSGDIKL
FLCTVYAPICT-PEEPIRPCRDLCLSAKNGCESLMIKFGFRWPEQLECKHFPTE-G--LCVGQNKTSSTPSPSRSYSPTNSLEC--------------PL
TMTASVRS----HFALPL----SSGTLEDCSLPCAADLVP--VFFDKRHRRYLRFWTGGWAVACCVCALFTITTFTIDLARFAYPVRPILYMAVCYLVIS
VVYMIGVVGEDSFACGPYGET-----VTQGGE-TACSALAVAHYYFTIASSVWWVVLCLAWFLAANRKWGAESIAGLAPYLHAASWGMPALLSVIVLVTN
-IDGDIFTGICSVGNLQPKVLFYYLFLPI-GCIILGLFLLACGICSMMRIRTYIKLQHKNIRKLEKLMFRVGGFAVMYVLPTAASAAVLCYQAVQM-FWL
DMRPTLRCI-HF-SMPRTDNMSPGPELILIFIKYLCQLIVGITCAVWICSAKTVASYQKVYVKI----------
>tr|A0A016UB05|A0A016UB05_9BILA Uncharacterized protein OS=Ancylostoma ceylanicum GN=Acey_s0048.g1616 PE=4 SV=1
-------------------------------------------PSGRKCVPLTIPMCMDLPYNMTVYPNLLNHQTQADAEIAINQFNPLVKVKCSEDIKL
FLCTVYAPVCT-QEKPIQPCRDLCLSAKNGCESLMIKFGFRWPEQLDCGHFPAE-G--ICVGENKTSSTPAPSRTHSSSNNLEC--------------PL
TMTASMRS----HFSLPL----SSGTLEDCSLPCAADQVP--VFFDKRHRRYLRFWTGGWAVACCVCALFTITTFLVDLARFAYPVRPILYMAMCYLMIS
VVYMIGVVGEDSFACGPYGGT-----VAQGGE-TACSGLAVAHYYFTIASSAWWVVLCLAWFLAANRKWGAESIAGLAPYFHAACWGIPALLSVVVLVTN
-IDGDVFTGICSVGNLQPKALLYYLFLPL-GCIVLGLFLLACGICSMMRIRTYIKLQHKNIRKLEKLMFRVSGFAVMYVLPTAASAAVLCYQALQM-LWL
D---TLRCL-HF-TMPRTDTMPPGPELVLIFIKYLCQLIVGITCAVWICSAKTVASYQKAYARI----------
>tr|F7E9U1|F7E9U1_MONDO Uncharacterized protein (Fragment) OS=Monodelphis domestica GN=FZD1 PE=4 SV=1
-------------------------------------------PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKF
FLCSMYAPVCTVL-QALPPCRSLCERRQ-GCEALMNKFGFQWPDTLRCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGSGAGRGKFSCPRA
LKVPSYLN-----Y--------HFLGEKDCGAPCEPTVYGL-MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVA
VAYIAGFLLE-RVVC-NEKFAE----VAQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALG
-VDGDILSGVCFVGLNNVDALRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR-QWE
RSW-AQSCKSY-IPCPHHPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL----------
>tr|A0A0L8I188|A0A0L8I188_OCTBM Uncharacterized protein OS=Octopus bimaculoides GN=OCBIM_22039182mg PE=4 SV=1
-------------------------------------------ANLIQCEPIAISLC-DLPYNQTGFPNPLNDQNQQAARVGLHGFLLLIESQCSPYGRF
FLCLLYTPACNEEV--LPPCRKVCERVQEDCEDTMNSFGFKWPEFLSCKRFPTSG---LCTGPKMGTD-RLTTHSSHFSEAEKRTFPQTTSQHQHQLLCP
PELRTPDKLNYKLI-------IGSFIIPDCGAPCI----G--MFFTESQVQFARLFNGILSSFALIPCFFVTVTFLINIQRFQYPQRVVLFQSFCYSLVS
LNYYLAAFYRDV-ACIDMAPLSCPNQVRQGTKNGICTLSFILVYFFSMAASVWSVIFGLVWFLAATKKWCSEAIEAKYLYYHSISWGLPILQTSILLNYG
-IGGDVLSGVCQTGLFNTTVLIASLLLPHTLYFLVSLIFRLTAFISLIRISKTNGR--RD------LLRKFRFFSVVSATCVSITISCLFYESLYKDQWL
STWY-RISNAT-----EQPDHPQQPSFVVFLLKYTVLYIHALLPAMFLANSKTFLTWTEICPDR----------
>tr|H3BEE0|H3BEE0_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD2 PE=4 SV=1
-------------------------------------------PDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKF
FLCSMYAPVCTVL-QAIPPCRSICERRQ-GCEALMNKFGFQWPERLRCENFPIHGAEQICVGQNHTDPEVTTV-FPALKAQDAGNPSPPKYDHPFNCPAV
LKVPAYLN-----Y--------KFLDEKDCAAPCEPSNNGY-MFFNQDEIKFARIWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVS
VAYIAGFILD-KVVC-NESFSE----VVQGTK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMG
-IDGDLLSGVCFVGLNNIDPLRGFVLAPL-VYLFIGTSFLLAGFVSLFRIRTIMKHDG-KTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR-HWE
KSW-SQNCKTL-IPCPLQYTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL----------
>tr|A0A0P6CDN3|A0A0P6CDN3_9CRUS Frizzled-2 OS=Daphnia magna PE=4 SV=1
-------------------------------------------XXXGNCDGFTIPLCKDILYNETIFPNLLNHQKQEDAGLEVHQFYPLVKVKCSPDLQI
FLCSVYAPVCTVL-KPIPPCRSLCLSARSGCEGLMNKFGFQWPESLECSRYPEGGAGELCVGENNTSSGTSHGGNEGYRPPYKVSGGLGGVDHGFICPAQ
FRVPKGLD-----YVVRV----GGKIYPDCGAPCKG------MFFNESEVRFSRVWIVIWGAICMASCLFTVLTFLLDVRRFRYPERPVVFLSVCYFMVA
LAYV--YAMG-SVSCNAPFDPPPDFS--------SCTILFMLLYYFEMAANLWWVVLTLTWFLAAGLKWGHEPIEAKSHYFHLVTWALPAALTIAILAMG
-VEGDVLSGVCSVXXXXXSALRLFVLAPL-IFLIVGTIFLLGGFISLFRVRTLMKSGG-KTDKLEKFMLRIGIYSFLYTVPAIIVIACLLHEQAFF-SWM
LRXXEDKCRDPVFACPSQAPTYPKPEFAVFMIKYLMMLIVGISSGFWVLSSKTLATWTNFYRRL----------
>tr|E5S837|E5S837_TRISP Frizzled-8 OS=Trichinella spiralis GN=Tsp_07874 PE=4 SV=1
-------------------------------------------AQYRRCQEISIPMCKSIGYNMTQMPNQFNHQTQEEAGMEVHQFWPLVEINCSPDLRF
FLCSMYTPICIAD-KPLPACRSVCERARAGCAPLMRQYGFEWPPNLDCDKLPVFGQDQLCMDSNQTEQQQSSSNNNAGSGFGSSTVRPTGRSRFACSCQC
RAPFVPVA---------A----QVGNVSHCTYPCRG--LFM----SSENHHFVTFWIGLWAVLCFMSTLVTVLTFLIDMHRFHYPERPIIFLSFCYLMVS
GGYLIRLVVGHPVACDGSA-------GSSGS-GAVCTVVFLLTYFFSMASSVWWVVLSLTWFLAAGLKWSNEAISGYSPYFHMFAWALPSVKTVAILALS
-VDGDPISGICSVGNTDVSWLRWFVLGPL-AYLVLGVFFLMAGFVSLVRIHHIVKQQQSKIEKLEKLMVRIGIFSVLYTIPATILIGCYFYEQHYR-LWE
IG--CQGPDCA--T--GRAHQPTKPEFSIAVLKYFMCLVVGITSGIWIWSPKTLDSWKRFCLRL----------
>tr|A0A0N5DH69|A0A0N5DH69_TRIMR Uncharacterized protein OS=Trichuris muris PE=4 SV=1
-------------------------------------------ESRRRCQEITIPMCKSIGYNMTEMPNQFNHQTQEDAGMEVHQFWPLVEINCSPDLRF
FLCSMYTPICIPD-KPLPACRSVCERARAGCAPLMRQYGFAWPLNLDCDRLPVFGLDQLCMDANQTERVGSGSTIRPTSGGKRPPLGGDPSSHRGCVCQC
RAPFVSLA----L--IRA----TVGNVSQCTYPCRG--LFM----SSENHHFVTFWIGLWAILCFASTVITVITFLIDMSRFHYPERPIIFLSFCYLMVS
TGYLIRLVVGHAVACDGNA-------TS-GD-GAVCTVVFLLTYFFSMASSVWWVVLALTWFLAAGLKWSNEAISGYSPYFHMFAWALPSVKTVAILALS
-VDGDPISGICSVGNTDVTALRWFVLGPL-AYLVLGVFFLLAGFVSLVRIHHIVKQQQSKIEKLEKLMVRIGIFSVLYTIPATILIGCYFYEQHYR-IWE
MT--CHGSDCG--TVTTVGVHLAKPEFGIAVLKYFMCLVVGITSGIWIWSPKTVDSWRRFCYRL----------
>tr|A0A085NLH8|A0A085NLH8_9BILA Uncharacterized protein OS=Trichuris suis GN=M514_06940 PE=4 SV=1
--------------------------------------------APALCERISVPVC-DMPYNFTRLPNLIGDQDQQSVAMSMHDFEPLIDIKCSVNLKF
FLCSVFTPMCTEAP--ITSCRSVCQEVERSCAPPLANFGIQWPSVLNCSQFPVQNSEPPCMDPSPAKGLSNRNRQKLERPFSSSRGATATTICSQSNSAL
YEMATPTDACGTQFA-MI---DRHDLHNKCVLRCNQ---H--WMFSGEQKRFVKIWMAAWASLCLLATGLTLVTFLLDGYRFAYPKRPVVFIALCHFMYS
IAYLLPIIAGARAACQRLTSG--Y-SVAHSLSNVWCVATFILRYYFALTSVVWWLILTMTWYLAAGRKWSQEAIARHSSMFHILAWALPAGLTVIVMVTH
-VEANELTSLCFICSQSNSALYGFFVGPIALLSAVGVGFMVAGVRSMVRIRKD---MRTELQKLRQLMTKICVFSLLYFVTTLVVLICISYERVFVDLWR
NAA-TSGCLQQDKYCKGRIPVHRRPVVEVYMLNIAMSMTVGVVSCLWVWSKKTVQTWQRFLCRS----------
>tr|A0A0N5DLF2|A0A0N5DLF2_TRIMR Uncharacterized protein OS=Trichuris muris PE=4 SV=1
-------------------------------------------WAPALCERITVPVCRDMPYNYTRLPNLIGDQDQQSVAMSMQDFEPLIDIKCSVNLKF
FLCSVFTPMCTEA--PITSCRSVCQEVERSCGPPLANFGIQWPSVLNCSQFPVQNSEPPCMDPSPAAKGLSSRPRMVDQPLSLGRGAAASGRQPMEPSTV
EGCGAQFT--MI-----D----RHDLHNKCVLRCNE---Q--WMFSGEQKRFVKVWMAAWAILCLLATGLTLATFLMDGHRFAYPKRPVVFIALCHLMYS
IAYLLPIIAGARAACQRL--S-----VAHSLS-PWCVATFILRYYFAMTSVVWWLILTMTWYLAAGRKWGQEAIARQGSLFHILAWALPAGLTVVLMVTH
-VEASELTSLCFVCSQSGSALYGFFVGPI-LLSAVGVGFMVAGVRSMGRIRKDMRYRATELQKLRQLMTKVCVFSLLYFVSTSVVLVCVAYERVFVDLWR
NAT-AAYVGR-D----HEPVERRQPVVEVYMLKIAMSMTVGIASCLWVWSKKTVETWQRFLCR-----------
>tr|A0A077Z9D7|A0A077Z9D7_TRITR Frizzled 9 OS=Trichuris trichiura GN=TTRE_0000511801 PE=4 SV=1
-------------------------------------------WAPALCERISVPVCRDMPYNFTRLPNLIGDQDQQSVAMSMHDFEPLIDIKCSVNLKF
FLCSVFTPMCTEA--PITSCRSVCQEVERSCAPPLANFGIQWPSVLNCSQFPVQNSEPPCMDPSPAKGLSNRNHRQHDRPSSSSRGATTTVSRYELATPT
DGCGTQFA--MI-----D----RHDLHNKCVLKCNE---H--WMFSGEQKRFVKIWMAAWASLCLLATGLTLVTFLLDGYRFAYPKRPVVFIALCHFMYS
IAYLLPIIAGVRASCQRL--T-----VAHSLS-VWCVATFILRYYFALTSVVWWLILTMTWYLAAGRKWSQEAIARHSSMFHILAWALPAGLTVIVMVTH
-VEANELTSLCFICSQSNSALYGFFVGPI-LLSAVGVGFMIAGVRSMVRIRKDMRYRATELQKLRQLMTKICVFSLLYFVTTLVVLICVAYERVFVDLWR
NSA-S-GCPHHNGGDKYCIPVHRRPVVEVYMLNIAMSMTVGIVSCLWVWSKKTVQTWQRFLCR-----------
>tr|T1JEY5|T1JEY5_STRMM Uncharacterized protein OS=Strigamia maritima PE=4 SV=1
---------------------------------------------PSRCEEITIPMCRGIGYNATFMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYAPICIDYLQPLPACRSVCDRAKAGCAPLMRLYGFAWPERMNCDRLPEYGDPSLCMDSKNGSS---PETTTRTPAITP---NKER-SGKHGMRGN
KGPPCQDCDCHSPLVSPLYNRVSTGRILNCAVPCRG------WFF-IQERSFTAFWIGVWSVLCFISTAVTVATFLIDVRRFRYPERPIIFLSACYLFVS
LGYIIRFLTDSRLSCHEGLMR--YE---AATSDGACNAVFLLVYFFGMASSIWWVVLAFTWFLAAGLKWGNEAIASYSHYFHLAAWFIPSVQSAVVLATN
AVDGDPVSGICSVGNANVVNQRGFLLAPLVACLVVGTTFLGAGFVALFRIRSVIKQQPAKADKLEKLMIRIGVFSVLYTVPATLVVACLFYEQHFRDHWE
RQWV--------CPKCHKTLPANNPDYSAFMLKYFMSLVVGITSGFWIWSGKTVDSWRRFYRRVGRSSGA----
>tr|A0A0P4WBW1|A0A0P4WBW1_9EUCA Uncharacterized protein OS=Scylla olivacea PE=4 SV=1
---------------------------------------------ESRCEEITIPMCRGIGYNNTSMPNQFNHDSQEEAGLEVHQFWPLVEILCSPDLKF
FLCSVYAPICIDYDKPLPACRSVCERAKAGCAPIMHQYGFEWPERMDCSKLPEYGDSDLCMDKSNGSA---PERKTSKMSTTL---DKEC-EGKNSRYC-
--HDACQCSCKLPLVGSANHSFSVGPVADCALPCHA------VYFNPDERTFAGVWVTTWAVLCGVSTLTTITTFLIDMDRFKYPERPIIFLSGCYFMVS
LGYVIRLAAGDYVACDGNMII--YN---SPHDSGLCNTVFLLVYFFGMASSIWWVVLAFTWFLAAGLKWGNEAIAGYSTWFHLAAWLIPTIQSIAVLMTH
AVDGDAVAGICYVGNQDITNLRVFVLAPLFVYLLLGSCFLLAGFVSLFRIRNVIKQQGTKTEKLEKLMIRIGVFSVLYTVPATIVLGCYVYEQLYVAEWH
EALV--------CPCSP-----QRPDYSVLMLRYFMTLVVGITAGFWIWSGKTLGSWRRFYRRLCPAAHA----
>tr|C6ERB7|C6ERB7_SCHJA Frizzled 5 OS=Schistosoma japonicum PE=2 SV=1
-----------------------------------------------KCIPIEIPLCKNIGYNLTYMPNAFNHETQEEAGLEVHQFYPLVEINCSEDLRL
FLCSMYTPICLPWHYRLTACKSLCESARDGCMPVMRTYGFGWPERMNCDLLPE---GNECVSRSNTPTNHKTTNTIHLYPSEQLHSNKNFSSITLEKLSS
KNQLLPVICLPCKCRDPFLNWMKTGGITGCLLSCYSP-----TFNNQSDKTFVTFWLGLWSVLCILSTLITVITFLADPNRFQYPERPIIYLSACYFMIA
LGYLLRVSLGHETVAC-----DGSMLRISTTGPVQCSIVFLLTYVFGMASSVWWVILTLTWFLAAGLKWGTEAIAKYSQIYHFFAWFFPGSQAIIVLILS
AVDGDPVSGLCTVGSTNLSYLRLFILVPMCIYLSLGTIFLLAGFVALFKIRNEIKRGHLKTEKLEKLMIRIGIFGVLYTVPATVVIACYCYELSNRDLWH
K--------SHNCPCTSPNYANVQPEYAVFMLKYFMSLIVGITSGFWIWSSKTIDSWQSCIKRAFN--------
>tr|T1E109|T1E109_9PLAT Fzd-5/8-4 OS=Dendrocoelum lacteum PE=2 SV=1
-----------------------------------------------KCVPIAIPMCKNIGYNLTYMPNEFHHETQEEAGLVVHQFYPLVEIACSENLRL
FLCSMYAPICLPWPKRIRACRSVCESARDGCAPVMNTYGFKWPKSMDCDKLTE---DQACLKKDTKNVTK------------------------------
---PQKSNGCDCKCRHPYILDNKTGGVHNCFQSCHSA-----NFVS-VDKSFVTFWIGLWAVLCCISSTATVFTFLLDRSRFKYPERPIVFLSGCYMMVS
TGYIIRVAMGHELIAC-----ENNRLRYGTTGPARCSVVFLLIYFFGMAASVWWVILTVTWFLSAGLKWGSEAIAKYSEIFHFMAWFLSGAKSILALTFV
AIDGDPIAGICYIGNTNPLHLKLFLIAPLLVYLLTGSCFLLSGFVALISIRKTIRKGETKTDKLEKLMMRIGIFGLLYSVPAAVVIGCHIYELKNRELWE
R--------SINCLCPR-DVSFFRPEYSIFMLKYFMCLVVGITSGFWIWTTKTLDSWNNAFRQVGR--------
>tr|A0A0R3WGK6|A0A0R3WGK6_TAEAS Uncharacterized protein OS=Taenia asiatica PE=4 SV=1
-----------------------------------------------KCELIRIPACQGLPYNTTILPNIMGHTSQEEAGQDITQYNSLVKIPCSPSLKL
FLCSLYFPVCTQLHKPLPPCRSLCEQNRQRCEPIMRSFSFQWPASMQCENFPE---NGLCVSEDKPETKETV----------------------------
----EATLECPEEMRVPSSF--EKQVIPNCGMPCNRH-----FFSQSKRIKFSRLWIGLWSGLCAASTLFTILTFFIDINRFQYPERPIIFLSMCYFMVA
VTYITGLSLGDKI-SC-----SYPLLITQGTKFEGCTILFMMLYFFSMAGHIWWVVLTVTWYLAARCHWAHEAIFRNAQYLHFAAWAIPAAMTICLLAMG
KVDGDPLSGVCFTGLTDPTIVRYFLVAPLCISLLLGACFLIAGFVSLFKIRTIIKTGGSKTNDLEKLIFRIGVFSLLYLLPAAVVIACYIYESQKMDRWM
LTW----YTNEVCRNFDSFDKMDTPTFELFMIKYLMTLIVGITSGIWVWSSKTLHSWHVFFARICR--------
>tr|A0A068XLR0|A0A068XLR0_HYMMI Frizzled 5 OS=Hymenolepis microstoma GN=HmN_000386300 PE=4 SV=1
-----------------------------------------------QCEPITVPICQGAFYEYTRMPNILNHETQEEAALEAHQFYPLIQINCSADLRF
LMCSIYTPICIEYAQSLPPCRSVCERAKAGCGPIMGYYAFTWPEQMQCDQFPVLNEGILCMERNLTDAEKAEFEAS-LFGTE-----------SGENSGS
LKTSGAWLNCSCDCRHPLVSGNDTLGFSHCALPCYSI-----HFQTETDKKFVDFWLWLWSALCAVSTIITMLTFLTDPSRFQYPGQPIIYLSTCYFFVS
VGYILRMAVGHENVAC-----TASILQYSLVGKAVCATVFIFTYYFGMASSVWWVLLTVTWFLAAGLKWSNEAISKYTQVFHFVAWVLPGVQTGVILMLR
AVDGDPVSGLCYVGSTNDNHLIYFLILPLVIYFCFGTFFLLGGFVALCNIRRVIKR--VGTDKLEKLMIKLGIFGLLYTVPAIVVIACYIHELRWRRVWQ
L--------GVACQCDW-DWSPPTPEYAIFMLKYFMSLIVGITSGFWIWSGKTVEAWKKICRRGRR--------
>tr|A0A0R3WKD8|A0A0R3WKD8_HYDTA Uncharacterized protein OS=Hydatigena taeniaeformis PE=4 SV=1
-----------------------------------------------RCEPITVPICSGAFYEYTRMPNILNHETQEEAGLEAHQFYPLIHINCSKDLHF
LICSIYTPICMEFTQSLPPCRSVCERAKAGCGPIMGYYAFTWPDRMHCDQFPELDEGILCMERNLTDAERVEFETS-V--VG-----------ADGNSEA
LSVSGAWLDCSCDCRHPLVPNNDTLGFQSCALPCHSI-----HFQTEADQKFVDFWLWLWSVICLISTLITMLTYLTNTSRFQYPGQPIIYLSTSYFFVS
VGYILRMVVGHDGVAC-----TASILQFSLSGRAACATVFLLTYYFGMASCVWWVVLTITWFLAAGLKWGNEAISKYTQVFHFVAWVLPGVQTGVVLMLR
AVDGDPVGGLCYVGSTSDNHLIYLLLLPLCTYFCFGTFFLLSGFVALCNIRRVIKR--VGTDKLEKLMIKLGIFGLLYTVPAIVVIACLVHELRWRRVWQ
L--------GVACRCDW-AWNPPTPEYAIYMLKYFMSLIVGITSGFWIWSSKTVDAWKSVCR-GRK--------
>tr|A0A0K0DGR6|A0A0K0DGR6_ANGCA Uncharacterized protein OS=Angiostrongylus cantonensis PE=4 SV=1
----------------------------------------------KGCELITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFFPLVEYGCYQHLKF
FLCTLYTPICQEYDRPILPCMELCLEAKKRCSPIMQQYGFRWPETLSCENLPMINSGNICAAPPDTPKQ--IKKVNV-----------------------
-------------------DGITVGNVSRCSYPCRA------ASLDAGKKELISGWMGIWAFACFFLSAFTFLTFLIETDRFQYPERPIFMLVFCQLMVA
IGFIIRVSAGHEQVGDATGI---------------RSVVFLLTYFFGMAACVWWIILSLSWVLAAASKWSSEAIASYSAHFHALGWLIPAAQTIVVLVFN
AIDGDPVSGMCYVGNTNVTHLRMFVLGPLIIYFSLGVLFLFVGFFNLWRIRNEVQPGLCNASKLTNLMTKIGTFSVLYTLPALFVILSLFYEQHHRPLWE
QS---ITC-----TCADRKLTAGDASFMLSMVKSFCMCVMGLTSAVWVCSRKTLNSWANII-------------
>tr|A0A0N4Y4Y5|A0A0N4Y4Y5_NIPBR Uncharacterized protein OS=Nippostrongylus brasiliensis PE=4 SV=1
----------------------------------------------RGCQPITIPLCKGVGYNMTSFPNSYGHEKQEEAGLEVHQFFPLVEYGCYPHLRF
FLCTLYTPICQEYDRPILPCMELCLEAKKRCSPIMQQYGFRWPETLSCETLPTMSSGNICAAPPDTPKT--VKAMDSPPAAPP----RPRVGISDIQNMC
ECSCQTPF------QIVNNPKAMVGNVSRCSYPCEA------PSLQAGKKELISGWMGVWAFACFFLSAFTFLTFLIETDRFQYPERPIFMLVFCQLMVA
VGFIIRVSAGHEQVCDSFKI-----KGIDDGNGSLCFVVFLLTYFFGMAACVWWIILSLSWVLAAASKWSSEAISSYSAHFHAVGWLLPAAQTIVVLVFN
AIDGDPVSGMCYVGNTDVNHLRMFVLGPLIVYFCLGVLFLFVGFFNLWRIRNEVQPGLCNASKLTNLMTKIGTFSVLYTLPALFIILSLVYEQHHRPLWE
QS---IIC-----TCGNRKPTAGDASFMLSMVKSFCMCVMGLTSGVWVCSRKTINSWTNLL-------------
>tr|A0A0F5D2I5|A0A0F5D2I5_PRIPA Cfz-2 (Fragment) OS=Pristionchus pacificus GN=PRIPAC_2946 PE=4 SV=1
----------------------------------------------QKCEPITIPLCMHIGYNFTSFPNSYGHEKQEEAGLEVHQFYPLVEYGCYKHLKF
FLCTLYTPICQAYDKPILPCKEMCVQARDKCSPIMQQYGFRWPETLACEKLPSKDTGEICAAPPDTPST--KGPNKSVDDPSD----RQV----GITTDC
SCRCASPF--------VPSSLSSVGRVANCAYPCAA------ANIDEDDRAFMDTWMTVWAVACTVASTFTLLTFLIEPDRFQYPERPIFVLAFCQLMVA
AGIGLRVYFGHEATCEQNAL-----KNTSESSTSVCFAVFLLTYFFGMAASVWWVLLSLTWVLAAGWKWSSEAIANCSLRFHAVGWLLPSAQTVIVIIFN
AIDGDPVTGLCYVGNTNVDHLRYFVLGPLVVYFIVGVFFLLIGFFNLWRIRSEMRLGIEGAGRITRLISKIGVFSVLYTLPALFAILTHFYEQERRPLWE
EA---ALC-----PCNRTAEPIPSVQLWLSLLKTASMLLLGCSTGFWVMNPKTFHSWKARL-------------
>tr|Q9U8U6|Q9U8U6_CAEEL Cfz2 OS=Caenorhabditis elegans GN=Cfz2 PE=4 SV=1
----------------------------------------------QKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKF
FLCTMYTPICQEYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSTGNICAAPPDTPKK--QHKGHHHNYSPD----GPEVGIS-GPSEC
QCTCNQPF------QFVASEKSKVGNVTNCAYSCHS------PALA-ESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVA
VGFMIRYFVGHEEICDSMRI-----KGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFN
AIDGDPITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQPSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQNHRSLWE
QS---QLC-----SCSPK-QTIGDSSLIISLIKTCCMCILGWTSGFWVCSTKTLSSWKNAI-------------
>tr|H2VMA2|H2VMA2_CAEJA Uncharacterized protein OS=Caenorhabditis japonica GN=WBGene00121877 PE=4 SV=1
----------------------------------------------PKCEPITIPLCKGIGYNMTAFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKF
FLCTMYTPICQDYDKPILPCMELCLEARNKCSPIMAKYGFRWPETLSCDELPKMATGNICAAPPDTPPK--KQKGHHQ----N----RPQVGIS-PSDQC
ECTCNQPF------QFVESEKAKVGNVSNCAYSCHS------PALA-DNQSLVSNWMAFWSITCCVLAAFTFLTFLIETDRFQYPERPIFMLAFCQFMVA
IGFMIRYFVGHEEICDSMRI-----KGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSTEAIASFSFHFHVVGWCLPAAQTVLVIFFN
AIDGDPITGICYVGNTDIQFQRIFVLAPLLVFFLVGVFFLIIGFFNLWSIRNEVQPSLESAHKITQLMSKIGIFSLLYTIPSLLIISVLFYEQNHRPVWE
QN---HLC-----SCSSSQSTVGDSSLVISLIKTCCMCVLGWTSGFWVCSTKTLSSWKNAI-------------
>tr|A0A0K0JB93|A0A0K0JB93_BRUMA BMA-CFZ-2 OS=Brugia malayi GN=Bm1_50235 PE=4 SV=2
----------------------------------------------QRCETITIPLCKGIGYNMTRYPNSYGHEKQEEAGLEVHQFYPLVEVGCYKHLKF
FLCAMYTPICQDYEKMVMPCMEVCLEAKKRCSPLMQQYGFKWPITLSCEQLPKISTGNICAAPPDTPDP--SILDPTDNRHPN----YPIIGINTIEGEC
KCRCSRPF------FNVLGSPASVANVSGCLYPCHS------PEQSLKDQKFLTAWITTWSGTCFILSAFTVLTFLIETERFQYPERPIFLLAFCQLMVS
IGFIIRIIYGHEHICDTTTI-----KANDQ-QMNLCQLIFLLIYFFGMAGSVWWVILSLTWVLAAASKWSSEAIASYANYFHFVAWSLPATQTIAVLIFG
AVDGDPLSGICYVGNTNVDYLKTFVFVPLTIYLIIGVCFLVVGFFNLWRIRSLMQPGGDNTSKMTQLMSKIGIFSVLYIVPAIFVLMVLSYEQHYRPLWE
RS---QLC-----NCAEQFDQA-DTFTLLALIKSASMLVIGWTSGVWIISRKTIQSWKRVL-------------
>tr|K4FUL8|K4FUL8_CALMI Frizzled-5-like protein OS=Callorhinchus milii PE=2 SV=1
----------------------------------------------MVCQEITVPMCKGIGYNLTYMPNRFNHDNQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSVYTPICLVYKKPLPPCRSVCERAKSGCSPLMRQYGFAWPERMNCDKLPVLG--NLCMDYNRTEVT--TLSPPFLKVN-T----KLRP-MPPGDCHG
ECRCKEPL------VLISKEKIKTGQVPNCAIPCYE------PYFNQDERTFATFWIGLWSILCFISTFTTVSTFLIDMERFKYPERPIIFLSACYLFVS
IGYIVRLITGHANVCNNDYN-----HIHYETGPALCTVVFLLIYFFGMASSIWWVILSFTWFLAAGVKWGNEAIASYSQYFHMAAWLIPSVKSIAVLALS
SVDGDPVAGICYVGNQNLDSLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATLVVACFIYEQHFRESWE
KA---LTC-----SCPGEENPR--PEYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRLFR-------------
>tr|H3B9V4|H3B9V4_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD5 PE=4 SV=1
----------------------------------------------IVCQEITVPMCQNIGYNFTYMPNQFNHDSQDEAGLEVHQFWPLVEIQCSPDLRF
FLCSMYTPICLSYKKPLPPCRSVCERARAGCSPLMRQYGFAWPERMYCDKLPVQG--NLCMDYNRTEAT--TVNPPYLNKN-T----RPGK-LPTGECDG
GCKCKEPL------VQISKEKVKTGKVPNCVIPCYE------PYFTQDERTFATFWIGLWSILCFISTFTTVATFLIDMERFKYPERPIIFLSACYLFVS
IGYIVRLIAGHANICNKDYN-----HIHYETGPALCTVVFLLIYFFGMASSIWWVILSFTWFLAAGMKWGNEAIASYSQYFHMAAWLIPSVKSIAVLALS
SVDGDPVAGICYVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACNIYEQHYRENWE
KA---LNC-----SCPGDKNPR--PNYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRRFR-------------
>tr|H9GFL4|H9GFL4_ANOCA Uncharacterized protein OS=Anolis carolinensis GN=FZD5 PE=4 SV=2
----------------------------------------------VTCQEITVPMCKGIGYNLTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCAMYTPICLLYAKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMGCDKLPLLG--QLCMDYNRTEAA--PASA---KPT-R----SKAKGGYSGTCKR
VCECREPL------VPISKEKIETGHVRNCAIPCFQ------PYFTQHEKTFATFWIGLWSVLCFVATFATVATFLIDMERFRYPERPIIFLSACYLFVS
IGYIIRLVVGHANVCNKDYN-----HIHYETGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHMAAWLIPSIKSIAVLALS
SVDGDPVAGICYVGNQNLDKLRGFVLAPLVVYLFTGTMFLLAGIVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIVVGCYIYEQHYRETWE
MA---QNC-----SCPGDKNLR--PDYAVFMLKYFMCLVVGITSGVWIWSGKTFESWKRFR-------------
>tr|A0A0N5ASI9|A0A0N5ASI9_9BILA Uncharacterized protein OS=Syphacia muris PE=4 SV=1
----------------------------------------------GKCESIRIPLCQDIGYNMTKYPNIFDHPKQEDAGLEVHQFYPLVKVNCYKHLRF
FLCTLYVPICQEYDKWIKPCREVCLAAKKGCEPLMIQYSFEWPKNLECDDLPKMSTGNICAAPPDTPDP--NTVDEVIFSSGR----YPLFN--LGNNQC
SCQCVHPF------HSVPERHSSVANVSGCAYPCYT------LTDDIHNKNFITAWIAIWAGTCFVLSAFSILTFLIEPERFQYPERPIFLLAFCQMMVS
VGFIIRVIYGHENVCSSNTI-----RLNDH-QINSCQIVFLLIYYFGMSGSVWWVILSLTWVLAAANKWSSEAIAGYAHYFHIIAWVLPVLQIMAVFIFG
AVDGDPTSGICYVGNTNVQHLLWFVFVPLLVYFVTGVGFLCVGFVNLWRIRSIMQQGIDNTSKMTQLMSKIGIFSVLYIVPAFFVLMVLLYEQHYRPIWE
RS---RLC-----NCAQQLDEKNNTWNLLVLIKTASMLIVGWTSGVWIISGKTVQSWKRVM-------------
>tr|A0A0N4ZSZ3|A0A0N4ZSZ3_PARTI Uncharacterized protein OS=Parastrongyloides trichosuri PE=4 SV=1
----------------------------------------------KRCEPITIPLCRGIGYNFTSYPNSYKHETQLEAALELNQFYPLVEVNCYKHLKF
FLCSMYTPICQEYEKSIMPCREVCLEAKKNCAPLMRQYGFNWPVSLSCSTLPRMSTGEICAAPPDTPDI--LDKENKMHPTLV----YPVIGIDVNQKKC
ECSCQNPF------VFTESSEQRIQNVSNCAYSCFG------QLPTQQTKNFINTWMSIWSGICFFLSLFTILTFLIETDRFQYPERPIFFFAFCQLMLS
LGFLIRIYHGHENICNGDLI-----KIGNH-TLSPCLLVFVLTYYFSMAVSTWWIILSLTWVLASGSKWSNEAIAAYAPFYHLFAWFLPAVQTFLVIILN
AIEGDPISGLCFVSNTS-HFQRSFVLGPLVVYFSVGVFFLCIGFLNLWHIRSVVKLGIQNTNKITQLMSKIGIFSVLYTVPALFYILVLFYEQYYRPLWE
QS---KLC-----TCADQVNENENAMYAFSLIKTAAMLFIGWTSGVWVINGKTFNSWKNVI-------------
>tr|A0A0B5CU58|A0A0B5CU58_OSCCA Frizzled A1 OS=Oscarella carmela PE=2 SV=1
---------------------------------------------PFRCEEIPIRECRAIPYNLTAYPNILNQRRAQDAKRDFQLIVRLLRDDCSDVIPF
FVCVMYAPFCNVDITRLPPCRELCEASRRGCESGMVAVGFSWP--FDCNNLPVFGDDNLCVGSNDTEKIVGSK-IREVFPPDKTLS------VNEQVV--
---GSEDKRCPRVLSADNMKDYTFGGLKGCGIPCPPLPSVDWYFSESERDEFAPNWILAWSIICFIATFLTLLTFLIDRDRFNYPERPIVLLAFCYFLVS
IIYIAGFQKAGNVACNSR---LGFLHQEMNGDSIDCAVQFLVLYFFTIASALWWVILTLTWYLAAGLAWGTEAINRWSSYFHLFAWTIPALLTIIVLALQ
KVDGDYLSGVCFVGVRDLRSHNIFVVAPLLACLLLGTFFLLAGFYSMFRIRSR----SKEKQKLEKFMARIGIFSVLYTVPAAIVVGCLIYESANRETWE
KTQLA--CA--RDD----RAIGSRPSFVIFMSKYLMLLLVGITSGFWIWSRKTVESWQSFLFQCRCIV------
>tr|T1D110|T1D110_SCHMD Fzd-4-4 OS=Schmidtea mediterranea PE=2 SV=1
---------------------------------------------KCLPKKILVPECQNLFYNFTGMPNLVNLETQIEAQSQLQTFQSLIKYKCSQNLLF
FLCSVYIPMCDPISNLIGPCQPLCEEVRDSCERIMRPFNLPWPVTLNCSRFPVRNAGSMCMEGPGPSVKS------------------------------
----NFQTMCG-------RLFIFINRTQKCVPKCSAN-----ILFTVDDKYIAKIWLTVLASLCFISSVFTILTFLINTDRFKYPERPVIFLAVCYSIYS
VSHFINLANTQSAACNRDP---QFILTQEGLDNTLCAIIFLLNFFFSTASQIWWVILTVAWLLAAGFKWSEEAIYQRSGYFHLAAWLISSLLTVAVLVLR
SVDADELLGLCSVGQQNVSTLLIFVIIPNIIFLVIGCFFLLGGLVALVRVRRH--KT-----KLEILMVRIGLFSVLFLVPSSTVLGCNFYEYANRDHWL
K--------------------GTNPNIEVYMLKIFMSSVVGITSGVWVWSIKTLESWQWFCLVKMCRK------
>tr|T1D142|T1D142_9PLAT Fzd-4-3a (Fragment) OS=Dendrocoelum lacteum PE=2 SV=1
---------------------------------------------KCIPQLIKVKQCRSQFYKYTHSQNLTSLNQVKNIDSEIDKYLSLLKGKCSKDLLF
LLCSNLTPFCDPNSKLVPLCGTTCKNVQKECGFEIKLLNLSWPKELNCSQFPIENEKSRCISIPRFERQVSKEI-VE------TNI-------N------
----FYLKKCG-------EKYIFINRTGRCALKCSEN-----DLFSRRMKKVAEIWMSSLAVLTFLSTMFTCLTCCHN-SKIKYPEQPIIFLTFSYNLYS
VSLLLRLFFTSIVSCDFDQ---QYILIQEGLENTHCAITFLLNYFFSTATHIWWVALTFCWMLYNVFKVSVSNLTNNSGYFHLFVWLPTSMLTVTVLVLR
CVEADELLGVCSVGGQSPDRLMTFSIIPKLVCLILGMFLLFVGFIFLKPEEEK--NIRWSTSSTSKVSCRIGLFSCIYVTATFISIVCEFYQYVNYVRWK
IQLKI--EE------------TAQPLVAIFLLNIFMNQIVGINSSVWIFSLDAAKSWRKFFATLKAKK------
>tr|T1E1E8|T1E1E8_9PLAT Fzd-4-4 OS=Dendrocoelum lacteum PE=2 SV=1
---------------------------------------------KCQPKRIIVQECQHLFYNFTAMPNLINHETQIEAQTQLLTFQSLIKYKCSAKLLF
FLCAVYIPMCDPNSHLIGPCRPLCEEVRDSCEKIMKPFSLSWPVNLNCSRFPKSNTGSMCMVGPGPSEKV------------------------------
----EVKVNCE-------SSFVYINRTQKCVPKCMAN-----ILFNSDDKYIAKIWLAVLSSLCFISSMFTILTFLINTDRFKYPERPVIFLAVCYSLYS
VSHFIRLLHNKGSSCNRDP---QYILTQEGLENTMCAIIFLLNYFFAIASQIWWVILTLTWLLAAGFKWSEEAIYQRSGYFHLFAWLISSLLTVSVLVLR
SVDADELLGLCSVGQQTASSLLIFVIIPNIIFLVIGCMFLLSGLIALVRVRRH--KT-----KLEILMVRIGLFSVLFLIPSSTVLACNIYEYVNKDFWL
T--------------------GTTPNIEIFMLKIFMASVVGITSGVWVWSIKTLDSWKWFFVVKLRRQ------
>tr|T1E111|T1E111_9PLAT Fzd-4-3b OS=Dendrocoelum lacteum PE=2 SV=1
---------------------------------------------KCKPQIIRAEQCRDKFYKYTSLPNLMGQDQEMDIQIQMDTFRPLLNHKCSNELNF
LLCSVYTPICDPEAELLGPCAGICEKVQTECEPILKIFNLPWPSGLNCSRFPSQSTELMCMSNPVFDSRSPLQL-F--------VV-------F------
----IHHGRCR-------EKYVFINRTGKCALKCSEN-----DLFSQESKRFAEMWMSVLAVITFLSTLFTCMTFCHS-NKIKYPEQPIIFLTLSYNLYS
VSLLLRLFFTSTVSCDYDP---QYILIQEGLENTYCAITFLLNFFFNIATHIWWVTLTSCWMLYSVFKVSSFNLKINAGYFHLFVWLSTSMLTVSILILR
CVEADELLGICSVGGQSPELLMTFSIIPKSICLIVGTLLLCLGFLFLKTRKKT--KIS--ITHITSVAFRMGIFSGIYILAISIHIVCELYQYINYNIWR
RAPQI--FR------------IKEPIVAIFLLNIFMGQVVGINSAIWIWSLDAATSWKSVFWNILKKK------
>tr|T1DBJ6|T1DBJ6_SCHMD Fzd-4-3 OS=Schmidtea mediterranea PE=2 SV=1
---------------------------------------------KCKPKPIAIGQCQNKFYNFTSL----SQDQEAEVQIPIETYRSLLSNGCSKHLNF
LLCSVYVPFCDYDTGQLEPCRKVCEKVQFDCEPILKLVNLSWPEKLNCSRFPLESSQMQCMHPSQEENLQQ----IQ------NLN-------H------
----QYRGQCR-------EKYVFINRTGRCALKCSEN-----DFFSKESKTIAEIWMKVITSLTFVSTLFTCVTFCHN-RRIRYPEQPIIFLTFSYNIYS
ISILLRLFLGEKVSCDFDP---QKILIQEGLENTNCAITFLLNFFFSTATHMWWIMLCLCWTLFCALNVSALSLAKNSGIFHLFVWLMTSVLTVSVLILR
SVDADELFGLCSVGEQTPDLLLTFSIIPQLICLIIGFIFLLSGFFFFKYRTKK---CHQKITFLLSIGFRLGLFSIIYIIAIATMICCELYQYYNYHYWS
RAPIK--FS------------RKDAIVAVFLLKFFMNQVVGINSAIWILSLDSVAAWKKCFVMLLTFN------
>tr|A0A0B5AI38|A0A0B5AI38_9CNID Frizzled 2 OS=Corallium rubrum PE=2 SV=1
---------------------------------------------KRKCEELAIPMCEDLGYNTTYMPNRFHHDTQKEAALEVHTFWPLVEIKCSPMLKF
FLCSLYAPICDKVYGELLPCRSVCEQAKAGCVKLMKEYGFAWPKKMECHLWPK-KTQTLCMSKPNSEPNPSWP-TDNAGSKTTSTKVVGATKTRGGVS--
STRQTCKCSCQVQRK----LERSVAGVYNCALPCNA------SYFTKEQKQFATTWVTLWSTLCFVSTFLTLATFFLNTARFGYPERPVIFLSGCYFLLS
FGYILRLIVE-AVICDKDG--------SETTGPALCTLVFLFTYFGGMASALWWVLLAFTWFLAAGMKWSNESISNVSQYFHIVAWLIPSVQTIAVLAMS
SIDGDPLSGICYVGNQSKDSLVVFVIIPLGIYLALGTTFLIAGFVSLFRIRKA----GSSTNKLEKFMVRIGVFSVLYTVPATVTIGCYFYEMTNREAWE
ESII---CR--EPPCSK----STKPDFSAFMVKYFMSLVVGVSTGFWICSMKTVESWRKILQRLFTFK------
>tr|A0A077SN24|A0A077SN24_9METZ Frizzled B SciFzdB OS=Sycon ciliatum GN=FzdB PE=2 SV=1
---------------------------------------------LQTADGGAEALCNGLNSTMAYVNGTLRRA--VVAELNQFAGIILTSSTCHAHMPL
FVCASFLPVCRSTHSVLYPCDEFCSAMEFSCSDLFVANRFVWPVRFNCNDTTRYPDRTDCLVLP---PLPGPV-STTLIPVTA-----------------
--------------------NMSGM----GSRPCNGD-----YYFQAENRSFITLWIAIWSVLCLLSSLITVATFFMDRERFNYPEKPIVFLSLSYSIFS
LAFIARLIAGTVLVCSGSE---------AGTNSGPCTIIALLLYFSWMASYSWWLVLTLTWLLAAGFKWGTEAIAKHSTHFHIIAWGAPALKTLVLVATE
NVDADELARVCSVGNFKKSSLLGFVIIPISVYLAIGTLFIIIGIASLIRIRTM----GRSTQKLEQLIVRIGILSVFYTGPASVVLGIYAHEYADRDHWR
THCT-------EPLCRPG--CCDAPIFAVYVVKYFMLLVVGVTSSVWIWSGKTVASWKRFTRRLCRRK------
>tr|G6CIS7|G6CIS7_DANPL Frizzled-2 OS=Danaus plexippus GN=KGM_10324 PE=4 SV=1
---------------------------------------------QPRCEEITIPMCRGIGYNLTSFPNALDHDTQDEAGLEVHQYWPLVEIKCSADLKF
FLCSVYTPICIEDYAPLPACRSVCERARAGCAPLMQKYGFQWPERMACEKLPRLGDEHLCMEEPDRAQEPRPP-PR----------------CK-ASP--
GEAGECACACRVSVRALHNASATAAGVPGCALPCRG------AFFTREEKEFAAVWVALWGGLCAASTLMTLTTFLIDSQRFKYPERPIVYLSACYFMVA
LGYLARLVIHDEVACDGAL---------SSNGPSACTLVFILVYFFGMASSIWWVVLSFAWFLAAGLKWGNEAIAGHAQYYHLAAWLVPAAKTVVVLLAG
AVDGDPVAGVCYVGNTSSENLKKYVLAPLVVYFALGATFLLAGFVSLFRIRSV--IGGSKADKLEKLMIRIGVFSVLYAVPAGVVIGCLAYEAEGREQWL
RRVA---CG--AS--------GPRPLYSALMLKYFMALAVGITSGVWIWSGKTLESWRRVWRGGRA-P------
>tr|B4L7U6|B4L7U6_DROMO Uncharacterized protein OS=Drosophila mojavensis GN=Dmoj\GI11047 PE=4 SV=1
---------------------------------------------FRQCEPIRIEMCRGIGYNETSMPNLVGHELQTDVEYTLQTFAPLIEYDCSSQLKL
FLCAAYVPMCTPKPVSIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCERFPRENNETMCMEGPGETHLTDHELGQQ-----L-------------PG--
-LKMPLPLDCS-------HLYVKLHRSGRCAPLCEAD-----ILFTPSEKHLSEIWVSTWAYAGLGLACVATLLLLLGGDHRGRGTAAASGNAWCHNMVT
IGWTVRFIVGTGTACGTDP--NESLLSVDGLSNAACASVFLLRYYFGMAACAWWAILCLGWHRDIRRNSGHIADLAQNNFVCFVAWGLPAFQTAAVIVMR
LVDADELLGACFVGNQSDKALQVLVATPVFCYWIFGSMNLISGYLVHCRNKEI----LSLQQQLQHNSSGIGIFLFIYGTACALLLLAVIYEFANIDVWL
SQ-------R-E----------STP-LWPYLTRAFMELMLGICCFAWVLGPSISSLYKRQLSMRP-LK------
>tr|A0A0A1WTD6|A0A0A1WTD6_BACCU Frizzled-4 OS=Bactrocera cucurbitae GN=fz4 PE=4 SV=1
---------------------------------------------LRQCEPIRIIMCRGIGYNETSMPNLVGNELQSDVEYTLQTFAPLIEYVCSTQLKL
FLCAAYVPLCTPKPLPIGPCRSLCESVRMRCHPVLQGFGFPWPPALDCNRFPKENNETMCIEGPGETQIHKEIFGAV-----I-----------------
---HSAVLECP-------HMYVKLYRYGRCAPLCEAD-----ILFGQHDKHLAELWVATWTYAEVFMALIAILLILNHNSKRN---------YWCHFMVA
LGWTVRFIVGTAASCGYDP--NVLLLLVDGLSNASCATTFLLRYYFFMSSCAWWAILCLTWHRDVRRINMCLSTIMQSNLANFIAWGLPAFQTAVVIVAR
LVDADELIGACFVGNQSDRALQILVATPLFCYWIFGSMNLGSGYLVYRRYKTL----PMLKQQLECPSYDFGMFLFIYSIPCAFILVSVIYEFVNIDIWL
NVPPY--FVATE---------FTTP-MWSFMTKALMEITLGIICFAWVIGPKISVLYKQHLELRN---------
>tr|W8BG70|W8BG70_CERCA Frizzled-4 OS=Ceratitis capitata GN=FRIZ4 PE=2 SV=1
---------------------------------------------LRHCESIRIDMCRGIGYNETSMPNLVGHELQSDVEYTLQTFAPLIEYVCSTQLKL
FLCAAYVPLCTPKPVPIGPCRSLCESVRMRCHPVLQGFGFPWPPALDCNRFPKENNETMCIEGPGETQSNHENFGAT-----I-----------------
---PTTTLECP-------HMYVKLHRSGRCAPLCEAD-----ILFGQHEKHLAELWVAAWTYADIFLALIAILLVLSDNSKRN---------NWCNFMVA
LGWTIRFIVGTATSCGYDP--NVLLLIVDGLSNAACATTFLLRYYFFMASCAWWAILCLTWHRDVRRIDECFSSIMQSNLASFMAWGLPAFQTAAVIVAR
LVDADELIGSCFVGNQSDKGLQILVATPLFCYWIFGSMNLGSGYLVYRRYKAI----PMMKQHFRCPSYDFGTFLFIYCVPCALLLISVIYEFANIDIWL
NIPPY--LVATE---------FTTP-MWPFLTRAFMEILLGIICFAWLLGPKISMMYKQQLVLRN-VK------
>tr|B4NC98|B4NC98_DROWI Uncharacterized protein (Fragment) OS=Drosophila willistoni GN=Dwil\GK25820 PE=4 SV=2
---------------------------------------------FRQCEPIRIEMCRGIGYNETSMPNLEGHELQTDVEYTLQTFAPLIEYDCSSQLKL
FLCAAFVPMCTPKPVAIGPCRSLCESVRIRCHPVLQGFGFPWPLDLDCERFPKENNETMCMEGPGEMHMPDHEFNTN-----G-----------VGSG--
---IKMPWDCS-------QLYVRLPRSGRCAPLCEAD-----ILFTPSEKHLSEIWVSTWSYAALGLALVATLLLLSDER------------SWCHNMVT
LGWNVRFLVGTGTSCGMDP--NELLLSIDGLSNAACVSVFLLRYYFLMAGCAWWAILCLGWHRDIRRHSGHMADLAANNFVCFLAWGLPAFQTAAVIVGR
LVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRNKEI----LSLHQQRNASTSGMGIFLFIYGLASALFLLAVIYEFANIDIWL
SA-------G-A----------STP-LWPYLLRAFMELMLGICCFAWVLGPTISTMYKRQVSQKQ-IA------
>tr|B3MRS8|B3MRS8_DROAN Uncharacterized protein OS=Drosophila ananassae GN=Dana\GF20940 PE=4 SV=2
---------------------------------------------FRQCETIRIEMCRNIGYNETSMPNLVGHDMQTDVDVTLQSFTPLIVYDCSSQLKL
FLCAAYLPMCTPKPVAIGPCRSLCESVQIRCHPVMQGFGYPWPPALDCKRFPKENNETMCMEGPGEMHQPEQDP--------G-----------MGMG--
---M---GDCS-------HLYVKLPRSGRCAPLCDAD-----ILFTPSEKHLAEIWVSTWAYAALGLALVSTVLLASDGT-------------WCHNMVT
LGWTVRFVVGTATACGTDP--NDSLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSGHVAELAQNNFVCFVAWGLPAFQTAAVLVFR
YVDADELLGACFVGNQSDKALQVLVATPVFCYWIFGSMNLISGYLVHCRTKEI----LTLQQQLQHSSSGIGIFLFIYGLACALLLLAVIYEFANIDVWL
GS-------G-D---------GGTP-LWPFLVRAFMELMLGICCFAWVLGPSISTLYKRQVGNGR-TK------
>sp|Q9NBW1|FRIZ4_DROME Frizzled-4 OS=Drosophila melanogaster GN=fz4 PE=2 SV=2
---------------------------------------------FRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKL
FLCAAYVPMCTPKPVAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNETMCMEGPGELHQPEQDLGLP-----G-----------IPGG--
---LKLPMDCS-------HLYVRLPRSGRCAPLCEAD-----ILFTPAEKHLAEIWVSTWAYAALGLALVATVLLASDGSR----------LAWCHNMVT
LGWAVRFMVGTGTACGTDP--NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSGHVVDLTQNNFVCFVAWGLPAFQTSAVIVAR
FVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEI----LSVQQQLQHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL
GS-------G-D----------NTP-LWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGK-MV------
>tr|Q29GB2|Q29GB2_DROPS Uncharacterized protein OS=Drosophila pseudoobscura pseudoobscura GN=Dpse\GA18313 PE=4 SV=2
---------------------------------------------FRQCETIRIEMCRGIGYNETSMPNLVGHELQTDVEYTLQTFAPLIEYDCSSQLKL
FLCAAYVPMCTPKPVAIGPCQSLCESVRIRCHPVLQGFGFPWPKALDCDRFPRENNETMCMEGPGEMHLPEHELGPV-----A-----------GAGG--
VGMGKLPLDCS-------HLYVKLPRSGRCAPLCEAD-----ILFTPSEKHISEIWVSTWAYAALGLAFVATLLLVGDDSK----------LAWCHNMVT
IGWTVRFIVGTGTACGTDP--NESLLSVDGLSNAACASVFLLRYYFGMAACAWWAILCLGWHRDIRRHSGHVANLAQNNFVCFVAWGLPAFQTAAVIVFR
YVDADELLGACFVGNQSDRALQVLVATPVFIYWIFGSMNLISGYLVHCRNKEI----LSLQQQLQHSSSGIGIFLFIYGLASALLLLAVIYEFANIDIWL
SS-------G-E----------STP-LWPFLVRAFMELMLGICCFAWVLGPSISTMYKRQISMRP-QK------
>tr|A0A0R3X1U4|A0A0R3X1U4_HYDTA Uncharacterized protein OS=Hydatigena taeniaeformis PE=4 SV=1
---------------------------------------------QAQCTPIREPVCQGLQYTDTRMPNWVKMTSQEEAAKRMIDYKSLLNINCSHYLKL
FLCTIYFPMCAPVEKPLKPCKSLCVHVRGRCEPIMQQFQFSWPTELACDDLPEP--PDLCIQPDGYALDAVLPASSNMYPQLQDLKG-----VA-SAS--
AASSSNVCSGA-------EFSAAHFSNDTCFTYCGAD-----LFYRPGDKKFARAWLLGWSILCVASSALTFFTFFIDGSRLQYPERPVLYLAACYFVIG
VGYILQYALPERVTCRSLQADIQKHLLMGGQESTWCTVGFLISYYFGMASNFWWVMLSLAWYLSTSRKWGHEGVESVSSVFHMFAWALPAIQAILILILH
KIDADELTGTCYTGFHSEASLMFGVLLPQAICLLLGLLLLSVGFAAVFRVRRK--ERRESRRRLEKSIAKLGVFVVLYTFPMACLLASNLYEYLGQPRWR
AALRE--LNAARPHCLSPGLPNDSPSSEAAMLRIFMSFVVGITSGMWVWANKTLVSWKRAIFRGCRSR------
>tr|E9FZ26|E9FZ26_DAPPU Wnt-receptor frizzled protein variant 2 OS=Daphnia pulex GN=FZ2.2 PE=4 SV=1
---------------------------------------------DARCEEITIPMCRGIGYNWTSMPNSLHHETQEEAGLEVHQFWPLVEIQCSPDMRF
FLCSIYAPICIQDYPSIPACKSVCLRAESGCAPLMRKYGFAWPDRMQCDKFPNFGDQNLCMDARNGSLPPAPP-PSQLLPLPPEV--EPLDRCKLLMN--
SGSSSCECQCRIRLGPNDSSSLSVGGIPNCLLPCSS------PFFSEDEQWFASLWIALWAAIAALSSALTFATFLIDRPRFRYPERPLIFLSACYVGLS
LGYLVRIVVGDVVACEGNATGASFIGVSSSTSSPACVVTFLLVYFFGQAAGLWWVILSLTWFLAAGRKWGSEAIARCSPYFHLVAWTIPAVQTAAALLMA
AVDGDSLAGVCHVGVQQTALLRWLVLFPLGLHLLLGGGFLLAGLAGLARIRRVLKEQRPKAEKLEKLMIRIGIFSVLYSVPAAILLGCYAYEVAFHVEWG
RTLT---CS--GCPSSPDATPQSRPDFSIFMLKYFMTLVVGITSGFWIWSHKTLDSWRKFYRRLCHSR------
>sp|O42579|FZD3_XENLA Frizzled-3 OS=Xenopus laevis GN=fzd3 PE=1 SV=1
------------------------------------------SMGHSACEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPMVNLECSRDLRP
FLCALYTPVCMEYGRMTLPCRKLCQRAYNECFKLMEMFGVPWPEEMECSRFPD------CDE--PYPRIVDIS---LS--GE------------PSEET-
PLQRDYGFWCPRELKIDPDLRSSFLGVRDCSPPCPH------MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LIFFIGFLLEDKVACNGANPQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMN
KIEGDNISGVCFVGLYDVHALRYFVLAPLCLDVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGVWE
TTWVQERCREYHIPCPYKV-QTSRPDLILFLMKYLMLLVVGIPSVFWVGSKKTCFEWASFFHG-----------
>tr|F6TUM4|F6TUM4_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=FZD3 PE=4 SV=2
------------------------------------------AGGHSSCEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPVVNLECSRDFRP
FLCALYAPVCMEYGRVSLPCRRLCQRAFGECAKLMEVFGLSWPEDMECSRFPD------CDE--PYPRPADLN---AA--AE------------PTAAT-
PAQRDYGFWCPRELKTEPALGYSFLRVRDCSPPCPN------MYFRREELAFARYFIGLISIVCLSATLFTFLTFLIDVRRFRYPERPIIFYAVCYMMVS
LIFFVGFLLEDRVACNAARPQYRAATVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIVLLAMN
KIEGDNISGVCFVGLYDVDALRYFVLAPLCLDVAVGVSLLLAGIVSLNRVRIEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAHRGVWE
TTWVRERCRDYHIPCPYQM-QMSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHG-----------
>tr|H0VFV3|H0VFV3_CAVPO Uncharacterized protein OS=Cavia porcellus GN=FZD3 PE=4 SV=1
------------------------------------------IGGHSSCEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRP
FLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMIVVDRLRNLYVSQFPD------CDE--PYPRLVDLN---LV--GD------------PTEGA-
PVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LIFFIGFLLEDRVACNASSPQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMN
KIEGDNISGVCFVGLYDIDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWE
TTWIQERCREYHIPCPYQV-QMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHG-----------
>tr|W5NGI3|W5NGI3_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
------------------------------------------AEGHSTCEPVILRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLQCSLDLRP
FLCALYAPVCTEYGRVSLPCRRLCQRAHRDCTKLMEMFGVSWPEEMECSRFPD------CDE--SYPRPVDLL---SS--LD------------STEES-
PMQRDYGFWCPRELKIEPDLSYSFLGVRDCSPPCPN------MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LVFFLGFLLEDRVACNAASPHYKASTVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTVILLAMN
KIEGDNVSGVCFVGLYDVDALRYFVLAPLCLDVLVGVSLLLAGIVSLNRVRIEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQSYRSVWE
ITWVQERCRDYHIPCPYQV-QTSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFFHG-----------
>tr|W5JYQ2|W5JYQ2_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
------------------------------------------VVSHSTCEPIGLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPMVNLQCSSDLRP
FLCALYAPVCMEYGRVSLPCRSLCLHSKRDCQNLMDMFGLTWPEEMECSRFPD------CDE--SYPRAVDLM---TS--AN------------TTDQS-
PMQRDYGFWCPRELKVEPELGYTFLGVRDCSAPCPN------MYFRREELAFARYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LVFFLGFLLEDRVACNAASPQFKASSVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGLLTVVLLAMN
KIEGDNISGVCFVGLYDVHTLRWFVLAPLCLDVLVGVSLLLVGIVALNRVRMEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLTVVGCYLYEQSYRSVWE
TTWVQERCREYHIPCPFQV-QTKRPDLVLFLMKYLMVLVVGIPSVFWVGSKKTCFEWASFFHG-----------
>tr|Q8R382|Q8R382_MOUSE Frizzled homolog 6 (Drosophila) OS=Mus musculus GN=Fzd6 PE=2 SV=1
------------------------------------------VRGHSTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLHLANLECSPNIEM
FLCQAFIPTCTEQIHVVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPH------CDD--TVPVTSHPH---TELSGP------------QKKSD-
QVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPPCPN------MYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVS
LMYFVGFLLGNSTACNKADELELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGAPGFLTVMLLAMN
KVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRITWE
MTWFSDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR-----------
>tr|G3VPF7|G3VPF7_SARHA Uncharacterized protein OS=Sarcophilus harrisii GN=FZD6 PE=4 SV=1
------------------------------------------IRGHSTCEPITVPKCVKMTYNMTFFPNLMGHYDQSIAAVEMEPFLPLANLHCSPEVDI
FLCNAFVPACTEQIHVVPPCRKFCERVYSDCKQLIDTFGITWPEELECSRLQY------CDE--TAPVASDLT---TKFHDP------------PKTPE-
QVQRDYGFWCPRHLKTSGGQGYKFLGIDHCAPPCPN------MYFKNDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVS
LMYFIGFLLGNSTACNKADELELGETVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMN
KVEGDNISGVCFVGLYDLYASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQIYRITWE
TTWVSDHCHRYHIPCPHQAKALARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWASFFNR-----------
>tr|F6SSF6|F6SSF6_XENTR Uncharacterized protein OS=Xenopus tropicalis GN=fzd6 PE=4 SV=1
------------------------------------------VQSHSTCEPITVPRCTGMNYNMTFFPNLLEHYDQDIAALRMEPFLPLLNLHCSPEVHT
FLCRAFVPECTEPKHITMPCRSLCERVYSDCKNLIETFGITWPAELECDRMRD------CNN--SQSKGGGGP---DDPHDA------------LRHPE-
QVHRDFKFWCPQHLKTSQGSGFKFLGVDRCAPPCPN------MYFKKVDMDFAKYFIGIISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYSVCYSMVS
LMYVIGFLMGNSIVCNEREEFASGDTVVLGSQHKACTIIFMLLYFCTMAGTIWWVMLTITWFLAAGRKWSCEAIEQKSLWFHGVAWGIPGILTIILLAMN
KVEGDNISGVCFVGLYDQEVSIYFVLLPLCLCVFIGLSLLLAGIISLNNVRQVIQHDERNQQKLKKFMIRIGVFSGTYLVPLVILLGCYVYEQVYRSSWE
MTWVSDNCQDYHIPCPFQL-NPARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVNFFNR-----------
>tr|A0A091DB47|A0A091DB47_FUKDA Frizzled-6 OS=Fukomys damarensis GN=H920_18557 PE=4 SV=1
------------------------------------------ASGHSTCEPITVPRCVKMTYNLTFFPNLMGHYDQGIAAVEMEHFLPLANLDCSPNVET
FLCQAFIPRCTEHVHVVPPCRGFCEKVYSDCKSIMDTFGIRWPEELECGRLQC------CNE--TVPTLN-PH---GRSLGP------------QKKNE-
QVQRDIGFWCPRHLKTSGGQGYKFLGIEQCAPPCPN------MYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVS
LMYFIGFLLGDHTACNKADGQELGATVVLGSQNKACSVLFMFLYFFTTAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGIPGFLTVMLLAMN
KVEGDNISGVCFVGLYDLTASRYFVLLPLCLCVFVGLSLLLAGIVSLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRVTWE
ITWVSDHCRQYHIPCPYQVKATARPELALFMIKYLMTLIVGISAIFWVGSKKTCTEWAGFFKR-----------
>tr|L8IC75|L8IC75_9CETA Frizzled-6 (Fragment) OS=Bos mutus GN=M91_04017 PE=4 SV=1
------------------------------------------VRGHSTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEIFLPLANLECSPNVET
FLCKAFVPTCTEQIHVVPPCRKFCEKVYSDCKKLMDTFGIRWPEELECDRLQY------CDE--SVPATFNPH---TELLGP------------HKKSE-
QIRRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPN------MYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVS
LMYFIGFLLGNSTACNKADELELGDTVVLGSQNKACTILFMFLYFFTMAGTVWWVMLTITWFLAAGRKWSCEAIEQNAVWFHAVAWGIPGFLTIMLLAMS
KVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWE
ITWVSDHCRQYHIPCPYQANTETRPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR-----------
>tr|A0A060X369|A0A060X369_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00011145001 PE=4 SV=1
------------------------------------------CHAHSTCEPIKVHRCLGMLYNMTFFPNMMEHYDQDIAASRMEPFMPLVNLRCSPDVHH
FLCQAFIPACTEDTKVIQPCRDLCEKVRSDCRKDIGTFGITWPPELQCDRLEY------CLY--SPDGSALPP---T-RLTT------------PKTSL-
SAKRDMGFWCPLQLKTRPGQGSTFLGARDCAPPCSN------MYFKPHEIEFAKTFIGVCSIVCLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFIGFLLGNNASCNKAVHPAAMDTVVLGSQSKGCTLLFMLLYFFSLAGIVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGVPGALTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVLAPLCIGVVVGLSLLLAGIVSLNNVRQVIQHDERNQEKLKKFMIRIGVFSGLYLVPLVTLQGCYIYEQSQRSTWE
NTWINDRCQEYSIPCSHK-TESGRPDLSLFLIKYLMTLVVGISAVFWVSSKKTCSEWAFFFNR-----------
>tr|Q4SMQ4|Q4SMQ4_TETNG Chromosome 8 SCAF14545, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis GN=GSTENG00015649001 PE=4 SV=1
------------------------------------------STAHSTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATNMKPFMPLIKLRCSPGVHH
FLCQAFFPACFE-NVGSRPCREECKTVLSDCKDNIQVFGISWPPELQCDKLDP------CFL--TRDDTT---------PET------------PPATS-
PTKRDLGFWCPLQLKTKPGLGSSFLGAQDCAPPCSN------MFFKPHDVEFAKSFIGVCSIVCLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LMYFIGFLLGDSVACARASHPASVDTVVLGSQSKACTLLFMLLYFFSVAGLVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGLLTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVLAPLCVGVAVGLFLILAGIVSLNNVRQVIQHDERNQEKLKKFMIRIGAFSCLYLVPLVTLLACYTYEQSHRSAWE
RTWIRDRCQEYSIPCPSEVGAGASRPLGGFLGQQQMGLLLGVRRRHVGPVSVRVECWFSFCCS-----------
>tr|W5MTD3|W5MTD3_LEPOC Uncharacterized protein OS=Lepisosteus oculatus GN=FZD6 PE=4 SV=1
------------------------------------------SWGHSTCEPIKVHRCLGMPYNATLFPNLMDHYDQDIAARKMEPFAPLIKMNCSAEVHL
FLCQAFVPVCIEPTKVLMPCRALCERVRTDCRSLIDMFGIVWPPELRCERFDE------CHS--SLDGSAAPP---MKQMTT------------QKPSP-
SVQRDFGFWCPRQFKTPPGQGSEFLGVADCAPPCTN------MYFKPHEIEFAKNFIGVSSIVCLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSVVS
LIYFIGFLLGNGTACNRADGLGSVETVVQGSQSKACTVLFMLLYFFSMAGTVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSVAWGIPGALTVMLLALN
KVEGDSISGVCFVGLYDLDALRYFVLAPLCLGVVAGLSLLLAGIISLNHVRQVIQHDERNQEKLKKFMIRIGVFSGLYLLPLVTLLGCYIYEQGYRKTWE
KTWISDHCQEYHIPCSYQ--VLDRPNLSLFLIKYLMTLVVGISAVFWVSSKKTCSEWAYFFNK-----------
>tr|Q6P0Y7|Q6P0Y7_DANRE Zgc:65879 OS=Danio rerio GN=fzd6 PE=2 SV=1
------------------------------------------CVSHTTCEPVQVQWCLDMPYNTTFFPNMLEHYDQDIAAVRMKEFMPLVSVRCSPDAHL
FLCQAFVPECRTHTHVLRPCRERCERVRSDCRAVMHTFDISWPSELQCERLES------CGG--SAVDVTT-----------------------AGRSG-
AGPRDLGFWCPLQLKLRPGQSGSFLGAPDCAPPCEN------MFLTAAEQHLARLFIGVCSVVCLCATLFTFLTFLMDAQRFRYPERPIVFISVCYCAVS
LLYLLGFMLGPSVACGAPG-PGGVWTVVLGARSRGCSLLFTLLYFCSTAGMLWWVILTITWFLAAGPKWSCEAIQKQALWFHAAGWGVPAVLTLLLLALG
KVEGDGISGVCFTGLYDLTALRWFLVAPLALAVLLGLALLLAGIVALNRVRQVIQHDQLNQQKLKRFMIRIGVFSGLYLLPLLLLLGCYLYEMTQRRVWE
SSWVNRHCQEFSIPCARTSSGVQHPGLSLFLLKYLMTLAVGIPAVFWVSSRKTCSRWASFCRR-----------
>tr|G3NMF6|G3NMF6_GASAC Uncharacterized protein OS=Gasterosteus aculeatus GN=FZD6 PE=4 SV=1
------------------------------------------CRAHSTCEPIRVHRCLGLTYNMTYFPNMMEHYDQDIAEAAMTPFMPLAGLPCSPDVHH
FLCQAFVPACSEDNKVIRPCRERCESVVSDCEEDVRVFGITWPPELQCDRLEP------CGS--A--GV--PT---L-PATT------------AISSS-
SAKRDLGFWCPLQLKTKPGHGSSFLGAQGCAPPCAN------MYFKPHDVEFAKNFIGVCSVICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFVGFLLGNNAACAGGDLPAGVDTVVLGSQSKGCTLLFMLLYFFTIAGIVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSVAWGIPGALTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVLAPLCVGVVVGLFLILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSSWE
NTWIHDRCQEYSIPCPYKVTEHERPDLSLFLVKYLMTLVVGISASFWVSSKKTCSEWAYFFNR-----------
>tr|H2SXD9|H2SXD9_TAKRU Uncharacterized protein OS=Takifugu rubripes GN=FZD6 PE=4 SV=1
------------------------------------------SSAHSTCEPIKVHRCLGMSYNMTFFPNMMDHFDQDIAATHMKPFMPLVNLRCSPDVHR
FLCQAFFPACIE-NTVYRPCREECNTVMSECKANIEVFGISWPPELQCDNLDP------CFL--I--GH--ET---S-TETT------------PV-TS-
STKRDLGFWCPLQLKTKPGLGSSFLGTQDCAPPCSN------MYFKPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LMYFIGFLLGNNAACTKATHPASVDTVVLGSQSKGCTLLFMLLYFFSIAGLVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGSLTVMLLALN
KVEGDNISGVCFVGLYNLDALRYFVLAPLGVGVIVGLFLILAGIVSLNNVRQVIQHDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSAWE
RTWIADRCQEYSIPCPFE-AESDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNR-----------
>tr|I3IU79|I3IU79_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=FZD6 PE=4 SV=1
------------------------------------------CYAHSTCEPIKVHRCLETSYNMTFFPNMMGHYDQDIAYNRMQPFMPLINLKCSPDVHH
FLCQVFIPACTEENKVIHPCREQCKAVRSDCEKNIHTFDVPWPPEM-CEKLDP------CSV--H--GS--P----V-PLTT------------PAISS-
SAKRELGFWCPLQLKTKPGHGSSFLGAQDCAPPCSN------MYFKPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFIGFLLGNNAACIKAAHPAGVDTVVLGSQSKGCTLLFMLLYFFSIAGIVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGALTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVLAPLCVGVIVGLFLILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSNWE
NTWINDRCQEYSIPCLNQ-TDHERPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNR-----------
>tr|W5L4U8|W5L4U8_ASTMX Uncharacterized protein OS=Astyanax mexicanus GN=FZD6 PE=4 SV=1
--------------------------------------------------------------------------------------MPLANLRCSPDVHL
FLCQAFVPECTEQTRVLRPCRAQCERVLSDCAANMQTFGITWPPELQCDRLEP------CKT--SVHGSEVPP---LKDITT------------PKSSP-
SASRDLGFWCPLQLKTHPGQGSAFLGAQDCAPPCEN------MYFKVHEIEFAKTFIGICSIVCLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSLVS
LIYFIGFLLGNEAACNKASQPGTVSTVVQGSQSKVCTLLFMMLYFFSTAGMVWWVILTITWFLAAGPKWSCEAIEKKAVWFHASAWGIPGSLTVMLLALN
KVEGDGISGVCFVGLYDLAALRWFVLAPQALGVVVGLSLLLAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSGLYLLPLLILLACYVYEQAHRSAWE
NTWINKRCQEYSIPCSYR-KDPSHPDLSLFLIKYLMTLIVGISAVFWVSSKKTCSEWAFFFKR-----------
>tr|H2LAG8|H2LAG8_ORYLA Uncharacterized protein OS=Oryzias latipes GN=FZD6 PE=4 SV=1
------------------------------------------CRAHSTCEPIKVHRCMGMPYNMTFFPNMMEHYDQEIAASKMEPFMPLANLRCSPDVHH
FLCQAFIPACTEDNRVIRPCREKCRAVLSDCRENIRIFDVTWPPELQCDKLDP------CVV--D--GS--V----P-PTTA------------QQTPS-
SPKRDLGFWCPLQLKTKAGQGSSFLGTQDCAPPCSN------MFFKPHDIEFAKSFIGVCSIICLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFIGFLLGDSAACAKASHHAAVDTVVLGSQSKGCTLLFMLLYFFTMAGMVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGALTVMLLALN
KVEGDSISGVCFVGLYDLDALRYFVLAPLCVGVIVGLILILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYLLPLVTLLACYTYEQSHRSSWE
NTWINDRCQEYSIPCSYK-TTPDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNR-----------
>tr|A0A0N8JXU6|A0A0N8JXU6_9TELE Uncharacterized protein OS=Scleropages formosus GN=Z043_116900 PE=4 SV=1
------------------------------------------TQGHSTCEPIKVPRCLGMTYNMTFFPNIMEHYDQDIAASKMEPFMPLINIQCSPDVHL
FLCQAFVPPCKGHNEVVQPCRALCEAVYADCAELLDTFGVSWPHELQCDRLQE------CRD--SPDGSAGPP---AKDMTT------------PRTSS-
SVGRDLGFWCPLPLKTQSGLGSSFLGVKDCAPPCGS------MYFKPHEVEFAKNFIGVSSIVCLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFVGFLLGNRAACGQAGGPGSVETVVLGSQNKGCTLLFMLLYFFSTAGIVWWVILTITWFLAAGPKWSCEAIEKKAVWFHSAAWGVPGALTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVMAPLCAAILVGLSLILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQAHRSTWE
TTWINDRCQEYSIPCSYT-KELARPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAFFFNR-----------
>tr|A0A087YNF2|A0A087YNF2_POEFO Uncharacterized protein OS=Poecilia formosa GN=FZD6 PE=4 SV=2
------------------------------------------CGSHSTCEPIKVHRCLGMPYNMTFFPNMMDHYDQEIAASKMEPFMPLASLQCSPDVHH
FLCQAFIPACSEENRVIRPCREKCEAVLSDCEENIRIFGITWPPELQCSKLKP------CGS--D--GS--A----L-PSTT------------PVTPS-
SLKRDLGFWCPLQLKTKPGHGSSFLGAQDCAPPCSN------MYFRPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVS
LIYFLGFLIGNNAACTKADHHGAVETVVLGSHSKGCTLLFMLLYFFTMAGIVWWVILTITWFLAAGPKWSCEAIEKKAVWFHTAAWGIPGALTVMLLALN
KVEGDNISGVCFVGLYDLDALRYFVLAPLCVGVVVGLFLILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSSWE
NTWINDRCQEYSIPCSHK-AELHRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFKR-----------
>tr|U3I631|U3I631_ANAPL Uncharacterized protein OS=Anas platyrhynchos GN=FZD6 PE=4 SV=1
------------------------------------------LRGHSTCEPITIARCSRMPYNMTFFPNIMGHYDQDTAALQMEPFLTLMNLHCSPDVHT
FLCKAFVPACLEQVHVIHPCRNLCEKVYSDCKPLIDTFGIAWPEELECNRLVN------CDE--TAPATAPVT---TNAHGT------------QKTPG-
QTRRDYGFWCPRHLHTSNGQGYKFLGIDQCAPPCPN------MYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVS
LMYFIGFLLGNRTACNKADNLEIGETVVLGSQNKACTVLFMVLYFFTMAGTIWWVILTITWFLAAGRKWSCEAIAQKAMWFHAVAWGIPGFLTIMLLAMN
KVEGDNISGVCFVGLYDVDASLYFVLLPLCLCVFFGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVSLLGCYVYELVNRKTWE
TTWVFDHCDQYHIPCPYQAKALARPEIFLFLMKYLLTLIVGISPVFWVGSKKTCSEWANFFNR-----------
>tr|H3B2R1|H3B2R1_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=FZD6 PE=4 SV=1
------------------------------------------VHTHSTCEPITVPRCLGMSYNMTFFPNMMGHYDQDAAAVKMEPFFPLMNLHCSPEVHT
FLCKAFIPVCTDHDCVVQPCRSLCEQVYSDCQNLIHTFGITWPEELECDKLEN------CGD--TLPGTILPT---SKSHSI------------PK-TP-
ELQRDYGFWCPRQLKTTPGQGSVFLTVNDCAPPCPN------MYFKSNELDFAKSFIGIFSIFCLCATLFTFLTFLIDVRRFRYPERPIIFYAVCYSIVS
LMYFVGFLLGNSTACSTADELGTTETVVIGSQNKACTVLFMILYFFTMAGTVWWVILTITWFLAAGPKWSCEAIEKKAVWYHTAAWGSPGILTVMLLAMN
KVEGDNISGVCYVGLYDLAALRYFVLVPLCLCVVVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVALLGCYIYEQAYRTAWE
STWIFDHCQEYHIPCPSQV-SMTRPDLSLFMMKYVMTLIMGISAVFWVGSKKTCSEWANFFNR-----------
>tr|K7FM15|K7FM15_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=FZD6 PE=4 SV=1
------------------------------------------IQGHSTCEPVTVPRCAGMTYNMTFFPNMMGHYDQDTAAVQMEPFLPLVNLHCSPDVHT
FLCKAFVPACIEQIYVIHPCRSICERVYSDCKQLIDTFGMTWPEELECNRLED------CDE--TAPVTAGVT---TKVHGT------------HKTPR-
QARRDYGFWCPRHLQTSNGQSYKFLGIDHCAPPCPN------MYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVS
LMYFIGFLLGNRSACNKADKLEIGETVVLGSQNKACTVLFMVLYFFTMAGTIWWVILTITWFLAAGRKWSCEAIEQKAMWFHAVAWGIPGFLTIMLLAMN
KVEGDNISGVCFVGLYDLDASRYFVLLPLCFCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVALLGCYVYEQMYRRIWE
TTWVFDHCAQYHIPCPYEAKTLARPEIFLFLVKYLMTLIVGISPVFWVGSKKTCSEWASFFNR-----------
>tr|Q4RKP7|Q4RKP7_TETNG Chromosome 5 SCAF15026, whole genome shotgun sequence OS=Tetraodon nigroviridis GN=GSTENG00032839001 PE=4 SV=1
-----------------------------------------------SCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTAALAMLPFHPMVNLECSPDLRM
FLCALYAPVCVVYGQVSMPCRSLCQRAKNQCHKLMEIFGVAWPEDMECSRFPD------CD---------------EPYPRPE---DLLTGSDPANQSSM
TVQREYGFWCPRELKVEADLGYSFMGRRDCSAPCPS------MFFHPQELTLIRYFIGVTSVVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYVMVS
LVFFLGFLLEDRVACNA-ASPARAATVTQGSHNKVCTLFFMVLYFFTMAGSLWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVALLALN
KIEGDGISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIVALNKVRMEIPLEKENQTKLVKFMIRMGVFSALYLVPLLVVLGCYLYEHTFRSVWE
RTWMEENCRRYHIPCPYEVKQTGRPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWADFMQGRKDSGVNE---
>tr|A4UAH3|A4UAH3_9CNID Frizzled receptor 3 OS=Clytia hemisphaerica PE=2 SV=1
-----------------------------------------------RCVPLINDHCKDLGYNATLIPNVKAGIDKLDEA---SEFSPLFQVNCYENFKF
FICNMFLPVCHSINGPVYPCRHVCEEARKGCEPLMKKYSFTWPDVLNCEFASNTKQNALCG---------------SPPPSKP---TRK---TPQTE---
VVPTAPPAWVKKGIDVKNSIYLKKTESETCVSKCEAT-----SPFTKENKKFASVWVSTWSIICFLSTLVTVTTFLVDHKRFKYPERPIIFLSFCYNLYS
IGYLIRVFGNENIVCEN-SPQ-GQHALIDGMSSTSCAIVFFLLYFFGMASALWWVVLSVTWFLAAALKWGHEAIEKYSSLFHAVAWTVPTIQTIIALVTR
KVDTDMLAGVCYIGATNSENLLMFVALPLLIYLLIGTLFLIMGFVALIKIRKELQRER-NTNKLERLIIRIGIFSVLYSVPASIVVGCFIHEYNRLKRTE
Q------VSQDMLSCLKNCEKDLKPRTEIFYLRYFMLLVVGVTSGVWIWTSKTFDSWKNFYRRREKSSKQE---
>tr|A0A0K8TV70|A0A0K8TV70_BACLA Protein smoothened OS=Bactrocera latifrons GN=smo_0 PE=4 SV=1
------------------------------------------CVRHGRCERLVNNTCFGITYSLTSLDLTDY-QNQDQMLKHLSNYRALRNVKCWAVIQP
FLCSVFMPKCEQKDMVYLPSVEMCRKTWEPCRILY--NSSYFPEFLRCN-ETLFPP--KCTNDVQD---------------------MKFNATGS-----
---------CL-PPLVPADSSSYYPGIEGCGVQCK------DPLYTDDEHRQIHKLISWLGTLCFLANLFVVATFIIDWEANKYPALIVFYINLCFMISC
LGWLAQFTPREDIVCRK--DGTLRHSEPTAGENLSCIVVFVLVYYFLTAAMVWFVFLTYTWHL-RAVGNVQDRIDKKGSYFHLVAWSLPLVLTITTMALS
EVDGNSTVGICFVGYLNHPMRAALLLGPLCGVILVGGYFVTRGMIMLFGLKHFANDIKSASNKIHLIIVRMGVCSIFTLIFILAAIACHVNEFKHSREWA
ESLGKIVCRIATEKCRI----ENRPSIALLQLHLICLFGSGIVMSTWCWTPSSLDTWRRYIRKKC---------
>tr|T1HLP2|T1HLP2_RHOPR Uncharacterized protein (Fragment) OS=Rhodnius prolixus PE=4 SV=1
------------------------------------------CKRPAKCEPLNYTTCLGLPYTWTSLDLVDGLVSQEQGQEQLKEWRRLVHIKCWAVIQP
FLCALYMPKCDD-HGVYLPSQEMCKIIMGPCRILV--SYEPWPAVFRCDNQTRYPP--MCKNDVRE---------------------LKFNTTGR-----
---------CL-EPLVQTDLSWYYDGVDGCGVQCH------DPMFTDHQRQQIHKLVAWGASICALFNLFTIVTFMIDWKSSKYPALVIFYINFCFFIVC
VGWLAQFLPREDIVCRK--DGTLRTAEPSAGENLSCVVVYVMVYYFLMAGIAWFVILTYAWHISQALGKIQECMEKKGAYFHLVAWSLPLVLTITTMALG
EIDGDAVTGICFVGSANKEYRAGFLLLPVAAALTVGTYFLSKGLVTLIRLQVDSKEIIRASNKIKETILRMGIFSVLILVLGATTFICHIYQFKNADLWT
KSFKIVLCKLGIGECKM----GSRPSVAMLQLHVLSLFSVGVLMSSWVWTHTTFNTWTTLIARLL---------
>tr|A0A0N8CT02|A0A0N8CT02_9CRUS Putative Class d atypical g-protein coupled receptor gprsmo1 OS=Daphnia magna PE=4 SV=1
------------------------------------------CRKTAKCQPIKTNICLTLPYSQTSLELVTDSHTQDDVQDKLMFWQNLKSVKCWAVIQP
FLCALYMPRCEN-GTVELPSQEMCKVIRNPCRIVELEQRGGWPDFMRCEDTEKFPS--GCKNEVRE---------------------LKFNITPK-----
---------CQ-SPLVETDNSAYVEGVDGCGLPCN------SPLFTKEEHEQVQRFTQTLVAMCLTTNLFAVFTFLIDWRASRYPAVIIFYMNVCFAAAC
IGWIAQYIPRQDIICRK--DGTARVSEPSGGETLSCVVIFILIYYFLMAACVWFVMLAYSWFVSQALFKIREKVSSKAAYFHLVSWSIPLVLTITCMALA
QVEAQSPHGICFVANSN-VVRSGFVLAPVLILLFVGHVFLYRGLLILIRLKLGSAASISANSKLRNTIVRLASFSISIIGSVVLTFVCHIYEFERRSQWK
TSFRSMVCLANQDDCEL----ESRPSMTITQVHLIAVFGAGVAVSSWVWTKASVLAWRRWYRRTF---------
>tr|H2Y562|H2Y562_CIOSA Uncharacterized protein OS=Ciona savignyi PE=4 SV=1
-----------------------------------------------RCEPIHIKMCQGIGYNSTRLPNSLGQVRQTEGDTEMKSFQILLEYNCASELKH
FLCAVFVPMCEPIQRTIGPCEGMCLSVQKLCLPALESFGQKWPEKLNCSNFPKENKQSMCMPGKVEIQD---------------EELPSYRPTPVRR---
-------NYCK-PPEIS------LQSQEGCAWKCH------KGMFSVEDKEFADLWMGICAGVCFVSTIFTVLTFLIDASRFRYPERPIILIAMCYNIYS
ISYILRLLVRENISCQR--NSEGE----EGLGNTVCAIVFLLSYFFGMASYLWWVILTLTWFLAAGMKWSHEAIERHSSYFHLVAWSIPSIKIVVILILR
HVDGDELTGLCYVGNQDMNALTGFVLAPLFTYLVIGTSFLLAGFFSLFRIKSYMEKEGSKTDKLERLMVKIGVFSVLYIVPASIVIGCYFYEHAVRRYTS
GNSPYI-YFLCIPCLNR----NVTPSVSIYFLRILMQLIIGVFTGFWVWSKKSIQSWRSCSHSIL---------
>tr|Q4H3F9|Q4H3F9_CIOIN Frizzled receptor OS=Ciona intestinalis GN=Ci-Fz4 PE=2 SV=1
-------------------------------------------EDDNRCEPIQIKMCQGLGYNATRMPNRFGQYRQTEAGIELNSYQVLLQYNCSSELPM
FLCAAFLPMCEPLERTIGPCEGMCLSIKKLCLPALKSFGYPWPEILNCSNFPKDNKQMMCMTGTHPHVK---------------DEQPLIRPTKIKR---
-------SYCR-QPQIS------LQSNEGCGWRCQ------QGMFSTEDKEFADLWMGVCSGVCFISTVFTVLTFLIDASRFRYPERPIILIAMCYNIYS
ISYILRLLVRNNISCQR--NTEGE----EGLGNTGCTVVFLLSYFFGMASYLWWVILTLTWFLAAGMKWSHEAIERHSSYFHLVAWSIPSIKIVIILILR
HVDGDELTGMCYVGNQDMNALTGFVLAPLFTYLVIGTSFLLAGFFSLFRIKSYMEKEGSKTDKLERLMVKIGVFSVLYIVPASIVIGCYFYEHAVRRLWA
--------------QNR----NVTPSATIYFLRILMQLIIGVFTGFWVWSKKSMQSWRQCSHSVL---------
>tr|A0A0N5E6V9|A0A0N5E6V9_TRIMR Uncharacterized protein OS=Trichuris muris PE=4 SV=1
-------------------------------------------PPNSKCEPITIPLCQDIEYNMTIFPNLLNHAKQEDAGLEVHQFFPLVKVRCSADLKF
FLCTMYAPVCTVLEEPIPPCRHLCLSAKNGCETLMNRFGFQWPDTLNCEKFPEEG---LCVGENKTHSTQRPNVDFVPWLTPSQGGDVTANATAPNGGYQ
C---PRRLQLT-TKDVSEYQVVGDEILRQCVLPCD------HMFFSRQEVEIVRVWIGVWSVMCAASTLFTVLTFLVDMRRFRYPERPIICLSGCYFIIS
IVYIVGF-VRDSIACRR--LGFHDATSSQGARSSACTILAIIEYYFTIASSVWWIVLNVTWFLAAGLKWGHEAIESKSHYFHLTAWGLPAVLMIVVLATQ
SIDGDVLSGICSVGNWDPETRRVFVLLPLFVCLTLGTFFLVAGFISLIKIRKFMKHDGGKIEKLEKLIIRISVFSVLYTVPALCLIACDLIQVTKFTQWM
VTWYDQ-CRNPSAGGAQ----APKPEFVAFMLKYLMTLVVGITSGFWIWSSKTIDSWQNFYLY-----------
>tr|A0A074Z9D5|A0A074Z9D5_9TREM Uncharacterized protein OS=Opisthorchis viverrini GN=T265_08477 PE=4 SV=1
-------------------------------------------DGLNQCVPIDEPICQGLEYTHTRFPNSVGLTSQEEASKRVNDYRALISVECSHYLRI
FLCTVYFPMCTPAFRTLQPCQSFCRHVQSKCEPIMKSFSFPWPKELNCNALPVASD--MCIKPQSYDQDQATGSLTQHPDKMKDVGKSAYSSIGGNLPLT
ADPQSKSVPCT-IMEVPL--VGKSNGNVTCARRC-------NIFYRAAEKRFADIWLLGWSILCAISCLLTIVTFIIDRSRFVYPERPIVYISACYLFYS
VGCILRIIVRERVSCYQ--RADDAAVVNSGYESTSCTLIFIIIYYFGQASYGWWVMLAVTWFLSTACKWGSEGVERVSSILHMFAWAVPAITTMIILILH
RIDADELTGLCYVGYQDRASLLIFVLIPQIVCLLLGLGLFVIGFFSLISIRTNLKRSNVSVRRLDKLMAKICIFSVLYVIPCICVIGANWYSYSGQDTWL
RSMREA-TRSGCDELQG----LTYPSIEVHMLHTFMSLVVGITAGMWVWCNRTFSTWVKCIRRQQ---------
>tr|I3KKG7|I3KKG7_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100702483 PE=4 SV=1
-----------------------------------------------TCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLVCSADLRM
FLCALYAPVCTVYGHVSMPCRSLCQRAKDECHKLMEIFGVAWPDDMECSRFPDCD---------------------EPYPRAE---DLLTGSEPTDQSSM
TVQRDYGFWCPRELKVDPDLGYTFMGRKDCSAPCPS------MFFNQQELTFIRYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYVMVS
LVFFLGFLLEGRVACN-PVSPSQFRTITQGSHNKACTLFFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAIAWGLPGALTVTLLALN
KIEGDGISGVCFIGLYDIDALRWFVLAPLCVNVAVGVSLLLVGIVALNRVRMEIPLEKENQTKLVKFMIRMGVFSVLYLAPLFTVIGCYIYEHTYRKIWE
KTWMENNCRRYHIPCPYKVEETSRPAMVLFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFLHGR----------
>tr|H2M6X3|H2M6X3_ORYLA Uncharacterized protein OS=Oryzias latipes PE=4 SV=1
-----------------------------------------------SCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEAFNTLVNLVLFKPFRP
PLFSTSPPSEIEQIRASLPCRQTTLHSHSEKSRLREKFESMWHHGLRVFRFPDCN---------------------EPYPRPE---DLLTDSEPTGQSSM
TVQRDYGFWCPRELKVDPDLGYTFMGRKDCSAPCPS------MFFNQDELMFTRHFIGAISILCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYVMVS
LIFFLGFLLEDRVACN-SVSPAQFRTITQGSHNKACTLFFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVTILALN
KIEGDGISGVCFIGLYDIHALRWFVLAPLCFNVVVGIFLLLVGIIALNRVRMEIPLEKENQAKLVKFMIRMGVFSVLYLIPLLTVIGCYFYEHTYRSIWE
TTWMEENCRRYHIPCPYKVEETSRPRMALFLIKYVMMLVVGIPSVFWVGSKKTCFEWAGFLHGR----------
>tr|A0A0F8B8K0|A0A0F8B8K0_LARCR Frizzled-3 OS=Larimichthys crocea GN=EH28_02196 PE=4 SV=1
-----------------------------------------------TCEPITLRMCQGLPYNSTFMPNILNHYDQQTAALAMEPFHPMVNLQCSPELRT
FLCALYAPVCTEYGRMTLPCRRLCLQAKSDCYKLMDMFGVSWPQEMDCNRFPDCD---------------------QSYPRPV---DLLSSSDTT-ESPV
SVQRDYGFWCPRELKIDPELGYSFMGVRDCSPPCPN------MYFTREELTFARYFIGVVSIVCLSATLFTFLTFLIDVSRFRYPERPIIFYAVCYMMVS
LVFFLGFLLEDKVSCN-AASPGRFRTVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHACAWGIPGVLTVSLLAMN
KIEGDSVSGVCFVGLYNLTALRWFLLAPLGLDVVVGVALLLAGIAALNRVRMEIPLEKENQEKLVKFMIRIAVFSVLYLVPLLAVLGCYLYENSYRAIWE
TTWVQEKCRDYHIPCPYQVERTSRPDLALFLIKYLMMLIVGIPSVFWVGSKKTCFEWASFFHGK----------
>tr|A0A060XXC0|A0A060XXC0_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00051641001 PE=4 SV=1
---------------------------------------------------------------------------------------------------M
FLCALYAPVCTEYGRMTLPCRRPCQRAKGDCYKLMDMFGVTWPEEMDCNRFPDCD---------------------ESYPRPG---DLLSSADST-ESPI
SVQHDYGFWCPRELKIDPNLGYSFLGVTDCSPPCPN------MYFQRDELVFARYFIGVVSIVCLSATLFTFLTFLIDVSRFRYPERPIIFYAMCYMMVS
LVFFLGFLLEDRVACH-AASSALFRTVTQGSHNKVCTLFFMMLYFFTMAGSVWWVILTLTWFLAAVPKWGSEAIEKKALIFHACAWGLPGCLTVTLTAMN
KIEGDSVSGVCFVGLYDRTALRWFLLAPLGLDVLVGVALLLAGILALNRVRMEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLTVITCYLYENSYRTVWE
TTWVQERCREYHIPCPYQIEQTNRPNLSLFLIKYFMMLVVGIPSVFWVGSKKTCFEWASFLHGQ----------
>tr|H2SYR7|H2SYR7_TAKRU Uncharacterized protein OS=Takifugu rubripes PE=4 SV=1
-----------------------------------------------TCEPITLRMCQGLPYNATFMPNLLNHYDQQTAALAMEPFHPMVNLQCSPDLRM
FLCALYAPVCTEYGRMTLPCRRLCLQARSDCYKLMDMFGVSWPQEMDCNRFPDCD---------------------EPYPRLV---DLLPTSGAT-ESPV
AVQRDYGFWCPRELKIEPELGYSFMGVRDCSPPCPN------MYFTREELTFTRYFIGVVSIVCLSATLFTFLTFLIDVSRFRYPERPIIFYAVCYMMVS
LVFFLGFLLEDRVSCN-AASPGKFRTVTQGSHNKPTCPPPLLLLLLLLLL--LLLLLLLLLLLLARPARXTEQYLRPHTHTHTHT----HTHTHTHTHTH
THTALSAGGLQLIGPLSLRAAHNEAIMTVCVFPCVSLLHCCSCISVIN---AD--CSGSSQ---PSFIFQ--LFA--FLQEVSIYLGCIDLNRFRFSLHY
SVMEAEQCLLQP--------DTSRPDLGLFLIKYVMMLIVGIPSVFWVGSKKTCFEWASFFHGN----------
>tr|Q5TZ38|Q5TZ38_DANRE Frizzled homolog 3 OS=Danio rerio GN=fzd3a PE=2 SV=1
-----------------------------------------------SCEPITLRMCQGLAYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLECSTEIRP
FLCALYAPVCTEYGRVTLPCRRLCQRAKSDCYKLMEMFGVSWPDEMECSRFPECE---------------------ESYPRAI---DLLPSSDSTEESPS
AVQRDYGFWCPRELKIEPDLGYSFMGVRDCSPPCPN------MYFRKDELIFARYFIGVISIVCLSATLFTFLTFLIDVGRFRYPERPIIFYAVCYMMVS
LVFFLGFLLEDRVSCN-TASPGRFRTITQGSHNKACTLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPGALTITLMAMN
KIEGDSMSGVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAALNRVRMEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWE
TTWVQERCREYHIPCPFKVEKTSRPDIALFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFSGH----------
>tr|W5KRL8|W5KRL8_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
-----------------------------------------------TCEPITLRMCQGLSYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSDDLRP
FLCALYAPVCTEYGRVTLPCRRLCQQAKSDCYKLMDIFGVTWPDEMTCNRFPDCD---------------------ESYPRAV---DLLSSADATKEPAV
SVQRDYGFWCPRELKVDPELGYSFLSARDCSAPCPN------MYFSRDELLFARYFIGMVSIVCLSATLFTFLTFLLDVSRFRYPERPIIFYAICYMMVS
LVFFLGFLLEDRVACN-RAAPGRFRTVTQGSHNKACTLLFMTLYFFTMAGSVWWVVLTITWFLAAVPKWGSEAIEKKALLFHAAAWGVPGALTVALMALN
KVEGDSVSGVCFVGLYDLSALRWFLLAPLALDVAVGVALLLAGIAALNRVRMEIPLEKENQDKLVKFMIRIGVFSILYLVPLLAVIGCYLYEQSYRPIWE
ITWVQERCREYHIPCPFKVEQTSRPNISLFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFHGH----------
>tr|W5U8P1|W5U8P1_ICTPU Frizzled-3 OS=Ictalurus punctatus GN=FZD3 PE=2 SV=1
-----------------------------------------------TCEPIMLRMCQGLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSADIRP
FLCALYAPVCKEYGRVTLPCRQLCQRAKSDCYKLMDIFGLSWPEEMACNRFPECD---------------------EPYPRAE---DLLSSANSTAESPL
SVQRDYGFWCPRELKVDPELGYRFLGVRDCSPPCPN------MYFSRDELVFARYFIAVVSIICLSATLFTFLTFLIDMGRFRYPERPIVFYSVCYMMVS
LVFFLGFLLEERVACN-KAAPGHFRTVTQGSHNKACTLLFMALYFFTMAGSAWWVVLTVTWFLAAVPKWGSEAIEKKALLFHAVAWGLPGVLTVTLMALN
RVEGDGVSGVCFVGLYDLTALRWFLLAPLALAVTAGVVLLLAGIVALNRVRMEIPLDKENQDKLVKFMIRIGVFSVLYLVPLLMVIGCFMYEQSYRPVWE
ITWVQEQCRNYHIPCPFKVEQMSRPNVALFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFHGH----------
>tr|A0A0N8JZ19|A0A0N8JZ19_9TELE Frizzled-3-like (Fragment) OS=Scleropages formosus GN=Z043_113243 PE=4 SV=1
-----------------------------------------------ACEPIALRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLQCSPDLRP
FLCALHAPVCTEYGRVSLPCRSLCLQAQHDCQKLMDMFGVAWPEEMDCNRFPDCH---------------------ESYPRAV---DLIASTEPTDQSSL
TVQRDYGFWCPRELKMEPELSYSFLGVRDCSPPCPN------MYFRHDELNFARYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS
LVFFLGFLLGDRVACN-AASPGQYRTVTQGSHNKACTLLFMGLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGVPGALTVTLLAMN
KIEGDNVSGVCFVGLYDVAALRWFLLAPLCLDVLVGVVLLLAGIVALNRVRMEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQSYRSVWE
TTWVQERCREYHIPCPYQVEQTSRPDLVLFLMKYLMVLVVGIPSVFWVGSKKTCFEWASFLHGR----------
>tr|T1DBJ2|T1DBJ2_SCHMD Fzd-5/8-4 OS=Schmidtea mediterranea PE=2 SV=1
---------------------------------------------PNKCVPIAIPMCKNIGYNLTYMPNEFHHETQEEAGLVVHQFYPLVEIACSDNLRL
FLCSLYAPICLPWPKPIQACRSVCESARDGCAPVMNTYGFKWPKSMDCDKLTENQA---CLKKDTKNVTKPPSKGCECKCRSPYIYDN------------
--KPQFN-------SV------ITGGVANCFQSCHS------ANFVSIDKSFVTFWLGLWAVLCCLSSTATVLTFLLDRSRFKYPERPIVFLSGCYMMVS
IGYIIRVAVGHELIAC---DGDKLRYGT--TGPARCSIVFLLIYFFGMAASVWWVILTITWFLSAGLKWGSEAISKYSEIFHFLAWFLSGVKSILALTLV
AIDGDPVGGICYIGNTNSLNLKLFLIVPLTVYLLIGSCFLLSGFIALISIRKTIRAKGSKTDKLEKLMMRIGIFGLLYSVPAAVVIGCHLYEVKNREFWE
--------KSNNCYCNRNQENFSKPEYSVFMLKYFMCLVVGITSGFWIWTSKTLDSWHNAFRRLSQSI------
>tr|T1DF88|T1DF88_9PLAT Fzd-5/8-1 OS=Dendrocoelum lacteum PE=2 SV=1
---------------------------------------------PPKCVPIEMSMCKDIGYNLTYLPNDLNHGSQEEAGLEVSQFFPLVEINCSEDLRL
FICSMYAPICLPWPNRVPACRSVCISARDGCITVMRQYGFKWPERMNCDTLPEDNA---CLRKGNETNNKLIPKKCKCHCRAPLIKDT------------
--RDYYN-------KI------ITGGVNNCLMSCRA------PYFTDFDKNFPTFWIGLWACLCIVSTTITMATFFIDRSRFQYPERPIIFLSFCYLLMA
IGYIIRVGLGHEAIAC---KGESIRYGL--TGTVPCSIVFLLVYFFGMASSIWWVILTATWFLAAGLKWSSEAITMYSDVYHFFAWFIPGFQSIFVLTMT
SVDGDPISGICFVGNTNKFNLLVFVIIPLLVYLLIGSGFLLAGFLSLMKIRKTIKEKGSKTDKLENLMLRIGIFGIVYSVPAITVILCCVYELLYRDKWE
--------KTYTCPCEQK---KFYPEYSVFMLKYFMTLIVGTTSGFWVWTSKTLDSWAKIICRSC---------
>tr|T1E0Z7|T1E0Z7_SCHMD Fzd-5/8-1 OS=Schmidtea mediterranea PE=2 SV=1
---------------------------------------------PSTCIPIEISMCKGIGYNLTYIPNDLNHASLEEAGLEIQQFNALVEINCSEDLRL
FLCSMYAPICLPWPNRIPACRSLCISAREGCTRVMNQYGFKWPEGMNCEKLPEDNA---CLRKDNKTRSNLKSKKCHCHCRSPLIIDS------------
--RDHFN-------KV------VTGNISNCLMNCRS------PYFGEFDKSFSTFWLGIWACVCIISTSVTILTFCIDKSRFQYPERPIIFLSICYLLMS
VGYLIRVALGHEAVAC---KSDAIRYGS--SGAVPCSIVFLFIYFFGMASSIWWVVLTATWFLAAGLKWGSEAILMYADIYHFFAWFIPGIQSIIILTMS
SVDGDPVSGICYVGNLNKYNLLFFVIIPLIVYLLVGTGFLLAGFLALMKIRKTIKEKGSKTDKLEKLMIRISIFGIVYSVPTMTVVFCSIYEFIFRDLWE
--------QSYTCPCRTK---KYQPEYSVFMLKYFMNLVVGTTAGFWIWTPKTLDSWSKVFCKLL---------
>tr|A0A085NTE1|A0A085NTE1_9BILA Uncharacterized protein OS=Trichuris suis GN=M513_01861 PE=4 SV=1
----------------------------TADAVPYSTSHHNQFESRRRCQEITIPMCKSIGYNMTQMPNQFNHQTQEDAGMEVHQFWPLVEINCSPDLRF
FLCSMYTPICIPYPKPLPACRSVCERARAGCAPLMRQYGFDWPPNLDCDRLPVFGQDQLCMDANQTERVGGSTIRPTSSSRRPPIGG-DFS------DAG
RGTHR---GCVCQCRAPPSLNRASVGVSQCTYPCR-----GL-FMSSENHHFVTFWIGLWAVLCFLSTVVTVITFLIDMSRFYYPERPIIFLSFCYLMVS
TGYLIRLIVGHDAVACD---GNAIRTTSGDGSAAVCTIVFLLTYFFSMASSVWWVVLALTWFLAAGLKWSNEAISGYSPYFHMFAWALPSVKTVAILALS
AVDGDPISGICSVGNTDVTTLRWFVLGPLFAYLVLGVFFLLAGFVSLVRIHHIVKQQQGKIEKLEKLMVRIGIFSVLYTIPATILIGCYFYEQHYRLIWE
MTI---TCHGS--DCGFAGVHVAKPEFSIAVLKYFMCLVVGITSGIWIWSPKTVDSWRRFCYRLC---------
>tr|U3FCN6|U3FCN6_MICFL Frizzled-5-like protein OS=Micrurus fulvius PE=2 SV=1
----------------------------------------------AVCQEITVPMCKGIGYNLTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF
FLCSMYTPICLLYAKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMNCAQLPVPGDAEMLCMDRNQTEPTTLAPSPFPKPTRSSKGAHKNLTPLASGDCK
RACACKEPLVFISRETHPLYD-------KVETGRVRNCAIPCFQPYFTQEEKTFATFWIGLWSVLCFISTFTTVATFLIDMERFRYPERPIIFLSACYLF
VSVGYIIRLIVGHANVACNKDYSHIH-YETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHMAAWLLPSVKSITVLALS
SVDGDPVAGICYVGNQNVDKLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRNVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIVVACYVYEQHYREKWE
AA---QNC-----SCPGDK--RPKPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWKRFTGRCCRGGKPV---
>tr|A0A068CJT9|A0A068CJT9_HOFMI Frizzled-7 OS=Hofstenia miamia PE=2 SV=1
----------------------------------------------DVCVPLLNKLC--SHYNMTRLPNALGHFTQEDVNLEIMQFVPLVEIGCSEDLQF
LICSVFFPMCSPYNERIPVCRPLCERAFKGCNPIMKEYGFDWPQAMSCEKFPVKKTSEVMCMDRPDANEKPKPPAPIASTDTKCECKCSEPLVTIPPSWD
AEYRQNITTAGIR------------------------HCAQPCHSAHLSSSEESFMSMWLALWSFLCSASTLLVFLTFLIDTARFPYPERPIIFLSVCYF
MVAAGFLTRGIFGHKIACSTDHPEMVRYE-AGSVLCTVVFVLVYYFGMAAALWWVILSLTWFLAAGLKWSSEAITTYSWWFHAIGWTLPAAQAVVAVFAQ
AVDGDSVAGICSVGNHNLFHLWLFVLGPLIGYMSVGVAFLFGGFVSLFRIRHVIKAGGTKTDKLEKLMIRIGVFSVLYTLPTIALVLCYLYEQHYRVEWE
RS---IAC-----NHA-----GRRPDYAVFILKYFMSLVVGTTSGFWIWTSKTITSWGQFVDKLLCRTRPV---
>tr|K7FD12|K7FD12_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=FZD5 PE=4 SV=1
----------------------------------------------PVCQELTVPMCKGIGYNLTYMPNQFNHDTQDEAGLEGHQFWPLVEVQCSPDLRF
FLCSVYTPICLLYAKPLPPCRAVWERAKAGCSPFMRQYGFAWPERMSCDRLPALGDPDTLCMDYNRSEPSTTAAPPALAKPTRSSRGPQRSLSPGSGADC
KIQTGQVPNCA----------------------------VPCFQPYFTQDEKTFASFWIGLWSILCFLSPPATVATFLIDMERFRYPERPIIFLSACYLF
VSLGYIVRLVAGHASVACNQEEGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVVLSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALS
SVDGDPVAGVCYVGNQSLGSLRGFVLAPLVVYLFTGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGVFTVLSTVPASLVVACYAYEQHYRESWE
PP---HTC-----ACPGEP--RARPDYAVFMLKYFMSLAGGITSGVWVWSGKTLDSWRRFTGRWCRRGEAG---
>tr|F6QAW3|F6QAW3_XENTR Uncharacterized protein OS=Xenopus tropicalis GN=fzd5 PE=4 SV=1
----------------------------------------------IVCQEITVPMCKGIGYNHTYMPNQFNHDTQDEAGMEVHQFWPLVVIQCSLDLKF
FLCSMYTPICLPYRKPLPPCRSVCERAKAGCSPLMRKYGFAWPERMNCDRLPEHGDPDTLCMDYNWTETTTTPPPTHPPKVKTPSSDCDGVCKCREPFLS
ITRESHPLYNRIKTG-------------------QVPNCAMPCFQPYFTQDEKTFATFWIGLWSILCFISTFTTVATFLIDMERFRYPERPIIFLSACYL
FVSIGYIVRLIVGHENVACNKD-HIH-YETTGPALCTVVFLLIYFFGMASSIWWVILTFTWFLAAGMKWGNEAIASYSQYFHMAAWLIPSVKSIAVLALS
SVDGDPVAGICFVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACYIYEQHYREHWE
KA---HNC-----SCPGDK--RYRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWKRFTGRCCRNSKPI---
>tr|V8PB20|V8PB20_OPHHA Frizzled-5 (Fragment) OS=Ophiophagus hannah GN=fzd5 PE=4 SV=1
----------------------------------------------IVCQEITVPMCKGIGYNLTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSLDLKF
FLCSMYTPICLLYAKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMNCDKLPVPGDTEMLCMDHNQTEPTTLPPLLTKPTRSSKGIHKNLTPLTSGDCKR
VCACKEPLVFISQETHPLYNK--------IETGHVRNCAIPCFQPYFTQDEKTFATFWIGLWSVLCFISTFTTVATFLIDMERFRYPERPIIFLSACYLF
VSIGYIIRLIVGHANVACNKDYNHIH-YETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHMAAWLLPSVKSITVLALS
SVDGDPVAGICYVGNQNVDKLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRNVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIVVACYIYEQHYREKWE
MA---QNC-----SCPGDK--RPKPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWKQFTGRCCRGGKPV---
>tr|A0A0F8APT6|A0A0F8APT6_LARCR Frizzled-9 OS=Larimichthys crocea GN=EH28_11421 PE=4 SV=1
---------------------------------SYDLERGR----PAKCEPIVIPMCEGIGYNLTRMPNFMDHDDQKEAAIKLNEFAPLVAYGCDVHLRF
FLCSLYAPMCTDVSTSIPACRPMCEQARERCAPIMKKFSYTWPDSLDCSKLPTRNPNALCMEANETRTEGKKGEGMLPVPPRP---------RQPGGTSG
RS-PGSMGSCENPDK------FQFVEKQSCAPRCSSA--V-DVFWSRQDKDFAFIWMTVWSILCFISTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYS
VAFVAGA--ENIA-C--DWENGELYIIQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIEAHSNYFHMAAWGIPALKTIIILTMR
KVAGDELTGLCYVGSMDSGALTGFVLIPLSCYLIIGTSFILTGFVALFHIRRVMKTEGTNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNMDYWK
LRGLQMKCGSFNALTGDCSLQTSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCSR-----------
>tr|H2YUA5|H2YUA5_CIOSA Uncharacterized protein OS=Ciona savignyi PE=4 SV=1
---------------------------------------------QATCEPIRVTMCKDIGYNLTDMPTYI--YDQKEAAKSVSQFSPLTRTQCAEEMKL
LVCSVYTPICIPYSNFLPPCRFICERAKQGCEPILKLYNRTWPNLFNCNRFPKTGDSQLCLHFNRSDGKATP-SGVVPSVTPVFK---------P----G
NG---CPCTCTRPMKDPL------YGKLNCAMPCKS-------PFSEERRKFAESWIT-WSVVCFVITMLTVGTYLIDTQRFKYPERPIIFLSACYMFVS
VGFIIRVVAGHEAVACAWHSD---HVLYQTTGPFLCSIVFLLLYFFGMAGALWWVVLSLTWFLAAGLKWGSEAIAGYSQYFHAAAWLIPALKSITVLAMS
SVDGDVLSGICFVGNQNTESLLGFVLAPLVVYLALGGLFLFMGFFNLFRIRNSIKKVGKKTNTLEKLMGRIGLFSLLYMVPSAALVACYFYEHQNRVLWA
KAY---NCRSHNGQDRCGHGSANGPEFAVFIVKYSMTLLIGITNGVWIISGKTVASWQRFYQRC----------
>tr|F7AFK4|F7AFK4_CIOIN Uncharacterized protein OS=Ciona intestinalis GN=cifrz PE=4 SV=2
---------------------------------------------TGMCEPIQVPMCIDIGYNFTDMPSYI--YDQKEAAQSVIQFGPLTKTKCAEEMKL
LVCSVYTPICIPYPGFLPPCRFICEAAKAGCEPILKKYDRTWPNLFDCKQFPDQGKNPPCLHFNRSGESKTP-GGPVASVTHPYK---------P----I
NG---CPCACARRMKDPL------YGKVNCAMPCKS-------PYSEEKRKFAESWITVWSVVCFAITMLTVGTYLIDTQRFAYPERPIIFLSACYMFVS
IGFIIRVVAGHEAVACAWHSD---RVLYQTTGPFLCSIVFLLLYFFGMAGALWWVILSLTWFLAAGLKWGSEAIASYSQYFHAAAWLIPALKSITVLAMS
SVDGDVLSGICFVGNQSTKTLRGFVLAPLVVYLALGGLFLFLGFVNLFRIRTSIKKVGKKTDTLEKLMGRIGLFSLLYMVPSAALVACYFYEQQNRELWA
KAY---NCRSFHGRDRCSHGNANGPEFAVFIVKYSMTLLIGITNGVWILSGKTITSWRKFYRRC----------
>tr|T1D138|T1D138_9PLAT Fzd-5/8-3 OS=Dendrocoelum lacteum PE=2 SV=1
------------------------------------------IHTDKKCERIKIPMCKDIDYNMTIMPNMFNHETQDEAGFEAHQFFPLVQIQCSEDLRF
FLCSIYTPICLQYGKSLPPCRSVCERVKKGCNPLLRKYKFKWPEKMECSQFPVFDNPELCMEKNIISVATTT----TNLMEEPIAQKD-FIK-----IDK
KTRTELSFQLSKQLNKPLIVSYSTLGMPNCALGCKL------AFFTESDQKFTNFWLGLWTTICLISTFSIVATFSIDPSRYRYPERPIIFISICYFMLS
LGFVLRLSMEEIA-CDSITGYGGQSLLYGSTGPAQCTIVFILIYYFGMAASLWWVLLTITWFLAAGLKWGSEAISKYSQIYHFIAWFIPGIKSIVALTMS
AVDGDSITGICYIGNTSDFNLALFVLAPLMLYLLIGTLVLFSGFASLFRIRNIIKITGGKTEKLEKLMIKIGIFSVLYTAPATIIIACLIYELQHRSEWY
QNL---SCDCY-----DTHRRLPQPIYAVFMLKYFMYMAVGITSGFWIWSKKTVRSWKIGCYRLG---------
>tr|T1DF42|T1DF42_SCHMD Fzd-5/8-3 OS=Schmidtea mediterranea PE=2 SV=1
------------------------------------------TNDKGKCEIIKIPMCKDIHYNMTMMPNMFNHENQDEAGFEAHQFYPLVQIKCSEDLQF
FLCSIYTPICLKYVKSLPPCRSVCERVKKGCDPLLQKYTFKWPEKMNCDQFPVYNNPELCMEKNLSTASTTL----ASVVT--LAPKE-QND-----ANS
RQENEVSYQLTRQYNKPLIV--STLGMFNCAQGCKS------PFFSESDQKFIGFWLGLWTIICLLSTFSIVATFSIDPGRYRYPERPIIFMSICYFMVS
LGFLIRIVMEDLA-CDLIKAKDGSSLLYGGSGPAHCTIVFLLIYYFGMAASLWWVLLTITWFLAAGLKWGSEAISKYSQIYHFLAWFLPGIKSIVALTMS
AVDGDPVSGICYVGNTSDFNLILFVLSPLLVYLTIGTLVLISGFASLFRIRSIIKLTGGKTEKLEKLMIRIGVFSVLYTAPAAVIVACIIYELQNRAEWY
QNL---SCDCF-----DSNRHLPRPSYSVFMFKYFMFMGVGMTSGFWIWSKKTILSWKMVCYRLG---------
>tr|G7YU88|G7YU88_CLOSI Frizzled 5/8 protein (Fragment) OS=Clonorchis sinensis GN=CLF_111043 PE=4 SV=1
-----------------------------------------------KCIPIEIPLCKNIGYNWTYMPNAFHHETQEEAGLEVHQFYPLVEINCSEDLRL
FLCSMYTPICVPWPYRLTPCRSLCESARDGCMPVMGTYGFGWPERMNCDLLP---EGSECVSRRNSTVSSRIHGKKTNWDQNNDLEDLKQSMSTEGRSEG
QQVFCLPCRCRDPFHKPPYNEVVTGGVTGCLPSCRNPAFN-----SKSDRTFTTFWLGLWAVLCILSTMATVATFLADPGRFQYPERPIIYLSACYLMVA
LG----YLIRV-GMGHESIACDGPMLRRGSTGPAQCSIVFLLTYVFGMASSVWWVILTLTWFLAAGLKWGSEAIAKYSQLYHFLAWFFPGAQAIFVLILS
AIDGDPVGGLCYVGSTDLNFFRVFVLAPMCVYLTLGTIFLIAGFVALFKIRSAIKLQHLKTDKLEKLMIRIGIFGVLYTVPATVVIGCICYELISREAWN
RN---HNCPCYPLPPVDGHTTTKQPEHAVFMLKYFMSLVVGITSGFWIWSSKTLDSWKFCLRR-----------
>tr|T1J176|T1J176_STRMM Uncharacterized protein OS=Strigamia maritima PE=4 SV=1
-------------------------------------------SRHSRCERITIPMCQDMPYNLTRMPNYMGHAEQSEAAIEVHEFIPLVEIGCSKHLKF
FLCSLYAPMCSQVDLAIPSCQSICEEVKTHCLPILQQFNFNWPRMLNCSRLPVPEMNELCMEFPTEERNSRPMGAQF-----------PFPRRPATTTET
TTETALGQVCPER----------FVRDAACVARCG--R---DVFFRRSDKRFAAVWMGVWACLCFVSTLFTLLTFAINHVRFHYPERSIMYLSGCYNVYS
VAYFVPLLAGRDAVSCETKSDS---MVVQGLDNTACTVVFLLLYYFGLASCVWWVILTFTWYLAAGKKWGYEAIDSLSSYFHVCAWAVPALLSIVVLTLR
HVDGDELTGLCHVERSSA----LFHIAPLGALFSLGVLFIALGLAAFFRIRRVMRVGGCNTDKLEKLMVRIGVFSILYMVPAAGVLGCLVYEFLQRPKWR
TLATL-----AAVECELSH---SIPSVEILMLKIFLSLAVGITSGMWVWSSKTWRAWRQLYLSCAR--------
>tr|B4PX33|B4PX33_DROYA Uncharacterized protein OS=Drosophila yakuba GN=Dyak\GE16636 PE=4 SV=1
------------------------------------------GPNGLQCQPIAVSACQGLGYNMTALPNLAGHTNQLE-AE-IAKLVPLIESGCSRRARF
LLCSSLFPLCTPVPRPVAACKLLCETVRGECVEAPPELMELWPSFLNCDGLPQPEKHELCMQQEAVPGGGPS-GPPAGSPSLEDQPYRFWKSGAPPAPGL
GG-----VLCPQNFSGSPF------NPEECVPQC--QR---DAFHTSAQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNQARMHDVE--VQGRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
KVRPSELTGMCYAP--------GFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTL-AHHRFGQIRKRFVVFSLLYFAPTTAGVVAALCERY-ADSV-
-----PSCSTP-DDCLPT---PLS--AWPALVRIFFQLVGGTLTGMWVWSRKTCESYRNRLGA-----------
>tr|A8JUT5|A8JUT5_DROME Frizzled 3, isoform B OS=Drosophila melanogaster GN=fz3 PE=4 SV=1
------------------------------------------GPTSLRSRILVLPPCTREELSFLPFGTILGSLVIDNHGFQIAKLVPLIESGCSRRARF
LLCSSLFPLCTPVPRPVAACKLLCETVRGECMEAPPELMELWPSFLNCDGLPQPEKHELCMQQEAVPGGSPS-GPPTGSPGVEDHPYRFWKSGASPTSDL
AG-----VLCPQNFSGSPF------NPEECVPQC--QR---DAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNQARMHDVE--LQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
KVRPSELTGMCYAP--------GFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTL-AHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCERY-ADSV-
-----PSCSTP-DDCLPT---PLS--AWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGA-----------
>tr|G7PJG3|G7PJG3_MACFA Putative uncharacterized protein OS=Macaca fascicularis GN=EGM_03901 PE=4 SV=1
------------------------------------------RPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAI-LHEFAPLVEYGCHGHLRF
FLCSLYAPMCTEVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNPNYLCMENNSDEPTRGSGP------------RPQRPHSHP-DGGP
GR-----GGCDNPGKFHHVE-----KSASCAPLCTPGV---DVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYS
VGYLIRFAGAESIACDRDS--G-LYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMR
RVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYEDYWKQHK-
-------CKMNNQTKT-D---CLMAAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSR-----------
>tr|B3MR18|B3MR18_DROAN Uncharacterized protein OS=Drosophila ananassae GN=Dana\GF21196 PE=4 SV=1
------------------------------------------GPNGLQCQRIAVSACQGLGYNMTALPNLAGHTNQLEAE-QIAKLLPLIESGCSPRARF
LLCSALFPLCTPVPRPITACKSLCTTVRGECAASAADLMELWPSFLNCEVLPQPEKHELCMQEEPAQGGLAEGSAAARHPELSPPPYRFWKNASGQSSGG
NG-----VLCPQNFSANPL------NPELCLPQC--QR---DAFHTTAQKKLTESLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNQARSLAAQ--MQDPRLRQGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
RVRPSELTGMCTAP--------GFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAAHHRFGQIRKRFVLFSLLYFAPTAAGVIAALCERY-VDSV-
-----PGCSTP-EDCAPA---PLS--AWPALVRIFFQLVGGTLTGLWVWSRKTCESYRSRLGA-----------
>tr|E2BJ61|E2BJ61_HARSA Frizzled-10 OS=Harpegnathos saltator GN=EAI_09999 PE=4 SV=1
------------------------------------------QKAEAKCERLSVSFCRGLRYNLTAMPNFMGHTDQVQAERRLATFMPLVHYNCSRHLRL
FLCAVFAPVCSEVTMQIPVCKSLCLSVRRDCEPALTVLALPWPHMLDCDRFLSQD-NVLCVKDETLDDSSLPV-------------QQQWPIVQPQEQQQ
HH-----HQCPPPFVQIPEI-----KTISCAPRC--GT---DAYYRAEDKRFAERWMTGWAWLCFLSTSFTLLTFWVEPSRFRYPERPIVFLALCYNLLS
VAYIVRVVGAENLSCAIQI-DGTYVPVRDGLKSVPCTIWWLVRYYLGLASSTWWAVLCGCWLLSARNEWSSEALHNIASYLHAAAWVLPVLFTGGSLLSR
NVVADELTGLCQISDES---ALWLEVVPHASLLLLGCVFGSIAGSALIRVRRAVRCAGRSATKLERLMTRLGIFALLYALPALGGLICVLHEPRWRLAA-
-----LDCRAT-QNCA-G---PVYRGLEVALLRLFLSLVVGVTSGMWVWSGKTCRAWSRLLAA-----------
>tr|E2ABY3|E2ABY3_CAMFO Frizzled-10-A OS=Camponotus floridanus GN=EAG_02841 PE=4 SV=1
------------------------------------------AGTGPKCEKLSVSFCRGLRYNLTAMPNFMGHEDQRQAER-LTTFMPLVHYNCSRHLRL
FLCAVFAPVCSEVAMQIPACKSLCLSVRRDCEPALTSLTLPWPHMLDCDRFLDRGRNTLCVQDETLDDAKSSA-------------TVQWPAMPLQQHQQ
QQ-----HQCPPHFVQIPDV-----ETIFCAPRC--GT---DAYYRAEDKRFAERWMTGWAWLCFLSTLFTLLTFWVEPSRFRYPERPIVFLALCYNLLS
VAYIIRAVGGENISCVSQI-DGPYVPIRDALKNIPCTIWWIVRYYLGLASNAWWAILCGCWLLSAKNEWSSEALHNIAPYLHAAAWILPILFTGGGLLSH
NVVADELTGLCQISDES---ALWLEVLPHTLLLFLGCIFGGIAGNALIRVRKAVRCAGRSATKLERLMTRLGIFALLYALPALGGLACVLHEPRWRLAA-
-----LDCRTT-QNCA-G---PIYRGLEITLLRLFLSLITGVTSGMWVWSNKTCRAWSKLLSA-----------
>tr|A0A0C9RZX5|A0A0C9RZX5_9HYME Fzd10-b protein OS=Fopius arisanus GN=fzd10-b PE=4 SV=1
------------------------------------------GNGNAKCERLTVSICRGLRYNLTAMPNFMGHTDQLQAER-LAAFMPLVHYNCSKHLRF
FLCAVFAPVCSEVAMQIPACKPLCLSVRRDCEPALTSLTLPWPNMWDCDRFSDSG-NALCVQSESLPEPVSPV-------------RPPWAGI--LPAAK
DH-----HQCPPHFVQTPFT-----DTISCTPRC--DA---DAYYRAEDKRFAVRWMTGWAWLCFLSTLFTLLTFWVDPSRFRYPERPIVFLALTYNLLS
ILFIIRAVGADILSCAHQE-DGPYVPVHDGLRSVPCTVWWLLKYYLALSSGVWWTILCGCWLLSARNEWSSEALHNIAPYLHATAWGLPLFLVAGSLISR
NISADELTGLCQVSDES---ALWLEVLPLGMFLILGCAFGGVAGAALVRVRRAVKAAGRSATKLERLMTRLGVFALLYALPAFGGLACALHEPRWRLAA-
-----LDCRAA-QNCA-G---PVYSGLEVALLRVFLSLVIGITSGMWVWSGKTCRAWSKLIAA-----------
>tr|K7J481|K7J481_NASVI Uncharacterized protein OS=Nasonia vitripennis GN=LOC100115634 PE=4 SV=1
------------------------------------------QGSSAKCERLNVSFCRGLRYNLTAMPNFMGHEDQLQAER-LAKLMPLVHYNCSRHLRF
FLCSVFAPVCSEVAMQIPACKPLCLSVRRDCENTLKDLTLPWPHMLDCDRFPDSG-NTLCVQPENLPAQDVTSSQPDDEEGEDSDAKAQWPLVQPPPRAN
LH-----QKCPAHFVETPYV-----DVTSCVPRC--GE---DAYYRAEDKRFAERWMTGWAWLCFLSTLFTLLTFWVEPSRFRYPERPIVFLALCYNLLS
VAYIIRAVGPESISCASQD-DGPYVPVNDGLRSVACTIWWLCRYYLGLASSLWWTILCGCWLLSARNEWSSEALHNIAAYLHAAAWGLPVLLTGGTLISR
NISADELTGLCQVSDES---TLWLEVFPNASLLLLGCFLAAVAGSALVRVRRAVRLAGRSATKLERLMTRLGVFAILYALPAFGSLACALREPRWRLAA-
-----LDCRSS-QNCV-G---PSSYGLEVALLRLFLSLVIGVTSGMWVWSGKTCRAWKLFHNR-----------
>tr|A0A034V4L7|A0A034V4L7_BACDO Frizzled-3 OS=Bactrocera dorsalis GN=FRIZ3 PE=4 SV=1
------------------------------------------GNNGLQCQRITVPACQGLGYNMTAMPNLAGHTNQLEAELRMTKLLPLIESSCSNRARF
LLCSSLFPLCTPVPRPVTACKQLCETVKSECET--AELMQLWPDFLNCDTLPQPEKHELCMQQEEKQQTNIQ--PQP----FQQPTW-PWSAWPH-----
PS-----AICPHNFTADPL------NAELCVPQC--NR---DAFHSTQQKKVAEGLILGLSAVCFVLTLFSLVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNSTRTLAMIE-DPLKIS-AACSVTPPCLASYITTSYLSLCAATWWLIFALCFFLSSHQKWSSEALEKKSGLFHVLAWVPPLAPPIAALLME
QVRPNELTGMCTAF--------GFVEIPALVLLLLGLFFTVRASRSLHMLQQQIKPIF-GHQRFSQIRKRFLIFSLLFFMPTIAGVLTSFFERY-IDTV-
-----PACSTH-EDCAPE---QRT--AWPTLIRIFFQLAGGTLTGMWVWSRKTCESYRSRLVA-----------
>tr|A0A0L0BY44|A0A0L0BY44_LUCCU Frizzled-3 OS=Lucilia cuprina GN=FF38_02990 PE=4 SV=1
------------------------------------------TTNGLQCQLITVTACQGLGYNMTALPNLAGHTNQLEAELRITKLLPLIESHCSNRIRF
LLCSALFPLCTPVPRPVTACTSLCDHVKRECSS--TDLMQLWPEFLKCENLPSPERQELCMQTLETAKLSADVTQPRVQAGGSAGHW-PWL--PH-----
PT-----AICPLNFTVNPL------NNDECVPQC--NR---DGFHSTQQKKVAESLILGLSAVCFVLTLFSLVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNSSRAFAVHE-DPLKTQLLPCSLTPPCLASYITTSYLSLCAATWWLIFALCFYLSSHKKWSSEALEKKSGLFHVLAWVPPLAPPIAALLLE
KVKPNELTGMCSAP--------GFVEIPAIVLLLLGLFFTLRASRSLHALQQQMLPTF-GHQRFSQIRKRFLIFSLVFFVPTLAGVVAIFFEPH-AEMV-
-----PTCSTR-EDCAPN---QMP--AWPTLIRLFFQLAGGTLTGMWVWSRKTCESYRSRLVP-----------
>tr|Q29IL3|Q29IL3_DROPS Uncharacterized protein OS=Drosophila pseudoobscura pseudoobscura GN=Dpse\GA14147 PE=4 SV=2
------------------------------------------HSSGLQCQRIAVSACQGLGYNMTALPNLAGHTNQLEAELQIAKLLPLIESGCSRRARF
LLCSALFPLCTPVPRPVTACKSLCETVKGECAAAGPELMQLWPPFLSCESLPQPEKHELCMQQEVHAAPTASASPPLSQQQQQQQQSRFWMSWGPGGGSL
AG-----IICPQNFSGSHL------NPEECLPQC--QR---DAYHTTQQKKLTESLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHNQARSLAQLQ-EPQLRLRPACQLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLVPPIAALLLE
RVRPSELTGMCSAP--------GFVELPALVLLLLGLYFTLRASRSLHSLQQQLQPTL-AHHRFGQIRKRFVIFSLLFFVPTAAGVVAALCERF-GDPV-
-----PSCSTL-EDCAPE---PLT--AWPALVRIFFQLAGGTLTGMWVWSRKTCESYRSRLVA-----------
>tr|B4JX00|B4JX00_DROGR GH17662 OS=Drosophila grimshawi GN=Dgri\GH17662 PE=4 SV=1
------------------------------------------NSNGLQCQRIAVSACQGLGYNMTALPNLAGHTIQLEAELQIAKLLPLIESGCSRRARF
LLCSALFPLCSPVPRPVTACKSLCETVQGECAVAAPELMQLWPPFLSCESLPQPENHELCMQQETATEAAENTAQPSGAAEPPQQQW-SWMARSQAGLGI
GG-----HICPQNFSASPL------NAEDCLPQC--QR---DAFHTTQQKKLTESLILGMSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHQARSLALLQEPGRGGRLGAACSLTPPCLASYISTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
RVRPSELTGMCTAT--------GFVELPALALLLLGLYFTLRASRSLHTLQQQLQPTL-AHQRFAQIRKRFVVFSLLFFVPTASGVLAAFF-RFV-DVV-
-----SSCSTL-EDCPPA---QLS--AWPALVRIFFQLAGGTLTGMWVWSRKTCESYRSRLVA-----------
>tr|A0A0M4EM29|A0A0M4EM29_DROBS Fz3 OS=Drosophila busckii GN=Dbus_chrXg540 PE=4 SV=1
------------------------------------------STNGLQCQRIAVSACQGLGYNMTALPNLAGHTNQLEAELQIAKLLPLIESGCSRRARF
LLCSALFPLCSPVPRPVSACKSFCETVKSECASAPPELMQLWPQFLSCETLPQPEHHELCMKQEASGGSDVVTGPPAQQQQQQQQQW-SWLAWAASALGT
SL-----IICPQNFSVNPL------NLGECLPQC--RR---DAYHSTQQKKLTESLVLGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHQARSFNLQLEKEPTVAARAACSLTPPCLASYISTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
QVHPSELTGMCHAP--------GFVEVPALVLLLLGLYFTLRAARSLHALQQQLPATL-QHQRFAQIRKRFVIFSLLYFVPTAIGVLAACLLSYVDSSV-
-----PSCSTL-EDCAPA---TLS--AWPALLRLFFQLLGGTLTGMWVWSRKTCESYRSRLVH-----------
>tr|B4MT43|B4MT43_DROWI Uncharacterized protein OS=Drosophila willistoni GN=Dwil\GK20092 PE=4 SV=2
------------------------------------------NSNGLQCQRIAVSACQGLGYNMTALPNLAGHTNQLEAELQIAKLLPLIESGCSRRARF
LLCSALFPLCTPVPRPVTACKSLCETVKSECAVASPELMELWPQFLTCETLPQPEKHELCMQQQGVQ-----------------AAWSNWLAWADTSISS
NN-----AICPQNFTINPL------NAQECLPQC--QR---DAFHTSQQKKLTESFILGLSAICFVLTLFALVTFWAEPRRFGYPERPVLFLCLCYNLFS
ICYLERVFHNQSRSRAIYE----PISTVCTLLSPPCLASYISTSYLSLCAATWWLIFALCFYLSSHKKWSSEALEKHSGLFHVLAWVPPLAPPIAALLLE
KVHPSELTGMCMAP--------GFVEVPALILLLLGLYFTLRASRSLHSLQQQHQLHLQHQQRFSQLRKRFVIFSLLFFIPTAAGLMLGAFYGAPPTIV-
-----PSCSTL-EDCSPD---KLS--AWPSLMRVFFQLLGGTLTGLWVWSRKTCENYRSRLVG-----------
>tr|B4L835|B4L835_DROMO Uncharacterized protein OS=Drosophila mojavensis GN=Dmoj\GI11128 PE=4 SV=1
------------------------------------------SPNGLQCKRIAVSACQGLGYNMTALPNLAGHTNQLEAELQIAKLLPLIESGCSRRARF
LLCSALFPLCSPVPRPVTACKSLCETVKGECAAAAPELMQLWPQFLSCDSLPQPENHELCMQQEAASEGSAVGA---AEPPPPQQQW-SWMAWAQVGVGV
GV-----GFCPQNFSVNPL------NGEECLPQC--QR---DAFHSTQQKKLTESLVLGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFS
VCYLERVFHQARSLALLQE--PGRAGRAACALTPPCLASYISTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLE
RVRPSELTGMCTAP--------GFVELPALALLLLGLYFTLRASRSLHSLQQQLQPTL-AHQRFAQIRKRFVIFSLLFFVPTAAGVVAAFC-RYV-EAV-
-----PSCATP-EDCVPA---QLS--AWPALVRIFFQLVGGTLTGMWVWSRKTCESYRSRLVA-----------
>tr|A0A0R3UC25|A0A0R3UC25_9CEST Uncharacterized protein OS=Mesocestoides corti PE=4 SV=1
---------------------------------------------------------------------------------QAHQFYPLIHINCSTDLHF
LICSIYTPICMGFSQSLPPCRSVCERARAGCGPIMGYYAFTWPDRMQCDQFPELPEGVLCMERNLTDASEKPGSGGVALEDRATLRDRSMAVVTATRADG
GGDVALECSCGSQLKVYEFFKISTLGFQGCALPCHS-----IHFQTEGDRRFVDFWLWLWSILCAVSTLATMLTYLTNPSRFQYPGQPIIYLSTCYFFVA
IGYILRMVVGHEVACTEVGGDTGLFTTAQLSGQASCATVFLLTYYFGMASSVWWVVLTVTWFLAAGLKWGNEAITKYTQVFHFVAWVLPGVQTGVVLMLR
AVDGDPIGGLCSVGSTNDSNLTYFLLLPLCIYFCVGTFFLLSGFIALCRIRHVIKFQRARTDKLEKLMIKLGIFGLLYTVPAIVVIACLAHEL----RWR
RVWQLGVCRCEEVRRHPLVWIPPTPEYAIFMLKYFMSLIVGITSGFWIWSSKTLDAWRRVCN------------
>tr|Q4H3G0|Q4H3G0_CIOIN Frizzled receptor OS=Ciona intestinalis GN=Ci-Fz3/6 PE=2 SV=1
-------------------------------------------NVHPQCRPVTLPMCLRWIYNETTFPNFNNDASESEVEISLSLLHPLLSTSCSRYLEL
FLCSVFSPACMG-GGVVPPCRSLCEVVFHDCAEVVEAFGIIWPQRLHCDNFPPQNGGKMV-D-TGSDTWGKLGDGEVCIPLSG--DDVITPALSQNNQEI
DNVTEYGLRCPAQLTAPPNPGYTFLGMQGCGAPCPN------MYMGDDELMLVRYIICVLASLCALVTSFVLFTFAIDTNRFRYPERPIVFYAAAYFVIS
VIFLVGFALGSDVACKHEIMDENNIVVVEGPRDRACTIVFMILYFFTVNGTIWWLILTVTWLLAAGFKWGSEAIEKHHLYYHGLAWGIPAVQTMVVVTTG
KIEGDNIAGVCFVGLYDSDGLRFLLLLPMSFYLLVGMFVLLTGFICLNRVRKSLHDDETNKKKLAKFMLRIGVFSIMYILPQLALIAIYAIEDSNRKSWE
SAWFVRNCGRYGVPCPNLPHPVPLPGVFIFCMKYIMTLIVALPPLFWVASKKTMASWKEAVTK-----------
>tr|Q95YK4|Q95YK4_CIOSA Cs-frizzled3 protein OS=Ciona savignyi GN=Cs-frizzled3 PE=2 SV=1
-------------------------------------------NVHPKCRPVMLPMCSVWIYNSTTFPNFNNDANEQEVEISMSAIHPLISTSCSRFLEL
FLCSVFSPACTG-NGVVPPCRSLCLKVKEDCEAVTQMFGVAWPPRLDCDNFPLQDD--MT-G-NGNDAGDALS--DVCIPLSG--DDVITPALSRGE-EE
ENVTDYEVRCPAHMRAPPDPGYTFLGLEECAAPCPN------MYLDPVELSIVRYIIIVLASLCVVVTSFVLFTFAIDTNRFRYPERPIVFYATSYLVIS
CIFIVGFILGPEVACNEQVTNEENKVVTEGFHRRFCTVVFMVLYFFTVNGTIWWLILTVTWLLAAGLKWGSEAIEKYSHYYHGLAWGIPAIQTMIVVTSG
KIEGDNIAGVCFVGLYDSEGLRYLLLLPMSLYLIVGIIVLLTGFICLNRVRKSLDD-EANQKNLAKFMLRIGVFSILYILPQVVLIAIYAIEDSNRKYWE
SAWFMVNCGNYGIPCPAEQHPVPHPGIIIFCLKYVMTLVVALPPLFWVASKKTVISWQNFVTK-----------
>tr|A0A095AR74|A0A095AR74_SCHHA Frizzled-8 OS=Schistosoma haematobium GN=MS3_05153 PE=4 SV=1
----------------------------------------------------------------------------------AHQFYPLVQINCSKDLRF
LLCSIYTPICIKYPHFLPPCRSICERVKAGCSPIMEHYEFPWPERMNCEQFPEYPDGILCMERNLTHITSQLQIINTNDQMKPTLEEIEFNNFNEEASDD
KLKMTFPLKCTCDC-RPPLINIKNSDIKDCSMPCYTP-----YYTFDSSYNFTTFWLGIWSTLCAISTMITIFTFITDSYRFQYPELPLIYLSACYFMIS
MGYLIRVFMGHQAIACDSLQAFDYNTITKLTGRVSCAVVFLLIYFFSMAASIWWVILALTWLLAAGLKWGSEAISKYSQVFHFIAWSLPASQTALALLLS
IVEGDPISGLCTIQSNKSITYILFIFAPLLIYLIIGIILMIIGFIALFHIRGTIKLQRIETQKLDKLILRIGIFGMLYTIPNLIILFSIGYELRHTYLWQ
LG---IACHQYLEPILPIVWNSPKPEYIIIMLKHFMNLMIGIISGFWIWSNKTIQSWKQFC-------------
>tr|G4LUN2|G4LUN2_SCHMA Frizzled, putative OS=Schistosoma mansoni GN=Smp_155340 PE=4 SV=1
----------------------------------------------------------------------------------AHQFYPLVQINCSKDLRF
LLCSIYTPICIKYPHFLPPCRSICQRVKAGCSPIMEHYEFPWPERMNCEQFPEYPQGILCMERNLTHGISDPLGTEKYDQIKTSIEDIELKNFNDDASDN
QLKTTFPLKCTCDC-RPPLINIKNLDIKDCSMPCYTP-----YYPINSSYHFTTFWLGIWSIFCAISTLITIFTFIIDSYRFQYPELPLIYLSLCYFMIS
MGYLIRVFMGHQAIACDSLQNFGYNTTTKLNGRASCAVVFLLIYFFNMAASIWWVILALTWLLAAGLKWGSEAISKYSQVFHFIAWSLPASQTALALLLS
IVEGDPISGLCTIQSNKSIPFLLFTFIPLLIYLIIGILFMMIGFIALFHIRGTIKLQRIEIHKLDKLIIRIGIYGMLYTIPNLIVLFIIGYELRNTYIWQ
LG---IACHQYVEPILPVIWNPSKPEYSIYMLKHFMTLMIGIISGFWIWSNKTIDTWRRFC-------------
>tr|G7YEG0|G7YEG0_CLOSI Frizzled 5/8 protein OS=Clonorchis sinensis GN=CLF_105936 PE=4 SV=1
--------------------------------TPFHEIVGSHLTDSHRCEPISLALCKGMEYQHTRMPNMFNHETQEEAGLEAHQFYPLVQINCSEDLRF
FLCSIYTPICIEYPSFLPPCRSICERVKAGCAPVMQHYNFPWPTRMNCAQFPEYPDGILCMERNLT--------GPEAHSTERTGN-----IEPPISVRE
KARMEKPE-IIIQLTNPPLTQVDRLNAEASQILLSFARHNKTMKQILNQRPGLRLKC---SCR-CKPA---VYRQYGSM--AEYPELPVVYLSVCYFMVS
IGYIIRVMLGHESVACELMSHSNYHQVHASTGRAACAAVFLFTYFFSIASAVWWVVLTLTWLLAAGMKWGSEAISKYSQVFHFIAWSIPTALSSLALLLS
AVEGDILSGLCVIRTSKPLQYVLFLFAPMVILLATGILFLVIGFIALFRIRGIMKLQSQKTDRLEHLMTRIGTFALLYTAPNLVVIICMGYELQNARAWE
FGV-ACDCHYINEPL-PEWYR-PSPDYQIFMVKHFMHLIIGVTSGFWIWSRKTVDTWRRACRRT----------
>tr|U1M941|U1M941_ASCSU Frizzled-4 OS=Ascaris suum GN=ASU_11180 PE=4 SV=1
--------------------------------------------SRSRCEPIEIPLCKDIPYKYTYFPNSLPQPDQQSLQTQTEHFKPLIKTNCNPHIKF
FVCSVFAPMCPEMPQAVTSCRSVCEEVKRDCVSILEKFGIEWPELLNCSRFPQ--APDLCMKPTNEHNS--------------YLGT---DQLESEQRDI
EGRKAIP-TCPNDLVLDPT-----DRNGHCALQCNRD---G--MFDDAKKEFARFWMLLWASINLAITTFTVLTFLIDRQRFRFPERSIFYLSACYMLFS
LPSLSAFISYERSAC-ERIP-TGQSFLIIGTLNTPCVISFILTYYFSMASSLWWLMLTFTWYLSAARKWVPEGIDAWSSYLHLVAWALPALLTIAVLTTH
KLDASELTGVCSVGNADPWALLGFAIIPKLIFVLVGSCLIIAGFSSMCRERDSFRRRGTDTSKLEKLMVKMGIFSALYIIPAITMVVCDSYH-MFA----
---------------------------ELYILNIFMSLAVGISTGMWTLSSKTFHSWQRVL-------------
>tr|A0A0R3SBC6|A0A0R3SBC6_HYMDI Uncharacterized protein OS=Hymenolepis diminuta PE=4 SV=1
------------------CILLLSVTSIASESEPFHGLKKPDDDDQAKCTPIREPVCQGLQYEVTIMPNWVKMTSQEEAAKRMIDYKSLLNINCSHYLKL
FLCTIYFPMCTPVLSALKPCKSLCMHVRSRCEPIMQQFKFSWPTELTCDDLPEP--PDLCIQPPN--GYGLDDQKP-VLPTAPHLQDLFL---K----RG
HGPPNIDFSISRGSS-QVCTGAEFPANDTCLTYCG-----ADLYYRPAGKKFARAWLLGWSVFCVFSSALTFLTFFADGSRLQYPERPVLYLAACYFVIG
LGYILQYSLPERVICRSQTIDSGSEGVTGGQESTLCTVGFLISYYFGMASNFWWVMLSLAWYLSTSRKWGHEGVESVSSVFHMFAWALPAIQAILILILH
KIDADELTGTCYTGFHSESALMYGVLLPQAICLVLGLLLLSVGFAAVFRVRRKLKAPRDNRRRLEKSIAKLGVFVVLYTFPMACLLASNLYEYLGQSKWR
SAALRPHCLSPAWGLPDC-HPKESPSTEAAMLRIFMSFVVGITSGMWVWANKTLMSWKRICH------------
>tr|E9JER6|E9JER6_SCHJA Frizzled 9 OS=Schistosoma japonicum PE=2 SV=1
-----------------------------------QGEIENGIDDVNHCIPIHEPICHGLQYTHTWLPNSVGLTTQEEAAKRMNDYRSLINVGCSHYLKF
FLCTVYFPMCTPTPAALQPCQNLCRYVQSKCEPIMKSFSFPWPIELNCKALPSDS--GMCIQQNISPGIPSEAHG----AIANLLPNFSFLAQLASTQDN
TERHHLIHRTKLQCYVVEILLYSEQNNITCA-----RRCNAHLFYKPVEKRFANIWMLVWSIICLGSCALTIITFTLNRTRFAYPERPIIYISVCCFVYS
----AGFILHDLVACVETISPVGTKGLTQGYEGTWCTIIFIILFYFSQASYLWWVMLATSWFLSASCKWGCEGIEAVSSIFHMLAWALPALKTIIILIMH
RIDADELTGLCNVGYQNSTSLLTLILLPQIIYLLLGIMFLLVGFHSLISLRSNLKQHKTTIRRLDKLMIKIGIFSMLYIIPCACVIGVNIYNYINYPEWM
KTLDKQTCWSLVTQCEDNHFPSAE----ANMLQIFMSLVVGITSGMWVWCNKSSETWLKCI-------------
>tr|A0A095C6K2|A0A095C6K2_SCHHA Frizzled-10 (Fragment) OS=Schistosoma haematobium GN=MS3_06023 PE=4 SV=1
-----------------------------------HGEAEEGVDDVSHCVPIHESVCHGLHYTHTSLPNSVGLTTQEEAAKRMNDYRSLINVGCSQYLKF
FLCTIYFPMCTPAPAALQPCQNLCRYVQSKCEPIMKSFSFPWPIELNCKSLPSES--GMCIQQNISQGIPSEAHG----AIANLLPDFGFLAHLTGAQDN
NGKHHILHRAKLQCYVVEILLYSEQDNITCA-----RRCNAHLFYKPIEKRFANVWMLVWAILCLASCAMTMITFTLSRSRFAYPERPIIYISVCYFFYS
----TGFILHDSVACVETISSEGAKSVAQGHEGTWCTIVFLILFYFSQASYLWWVMLAISWFLSASCKWGCEGIEAISSILHMLAWAVPALKTIIILIMH
RIDADELTGLCNVGYQNSTSLLAFILLPQVIYLLLGILFLLVGFHSLISLRSNLKQHNTKIRRLDKLMIKIAIFSMLYVLPKACVIGVNIYNYINYPKWM
KTLDKQTCWSLVTQCSDNHFPSVE----ANMLQIFMSLVVGITSGMWVWCNKSSETWIKCM-------------
>tr|W6V975|W6V975_ECHGR Frizzled-10 OS=Echinococcus granulosus GN=EGR_01918 PE=4 SV=1
-----------------LILLLLTVTSIKGESEPFHGLKKPPDDDQAQCTPIREPVCQGLQYTDTRMPNWVKMTSQEEAAKRMIDYKSLLNINCSHYLKL
FLCTIYFPMCAPLETPLKPCKPLCVHVRSRCEPIMQQFQFSWPAELACDDLPEP--PDLCIQP---DGYALDTQKP-ILPTAPQLQDLFL---K----RG
HGSPNIDSLIQAAAAVNVCSGAEFFSNDTCFTYCGA-----DLFYRPGDKKFARAWLLGWSILCVASSALTFFTFFVDGSRLQYPERPVLYLAACYFVIG
VGYILQYSLGERVTCRSLQTGDSNALLMGGQESAWCTVGFLISYYFGMASNFWWVMLSLAWYLSTSRKWGHEGVESVSSVFHMFAWALPAIQAILILILH
KIDADELTGTCYTGFHSETSLMFGVLLPQAICLLLGLLLLSVGFAAVFRVRRKLKAPSDSRRRLEKSIAKLGVFVVLYTFPMACLLASNLYEYLGQPRWR
AALELNTCLSVAWGLPE-CHPKDSPSSEAAMLRIFMSFVVGITSGMWVWANKTLMSWNRAVF------------
>tr|A0A075A636|A0A075A636_9TREM Uncharacterized protein OS=Opisthorchis viverrini GN=T265_02641 PE=4 SV=1
-------------------------------------------------MPIQIPECQNTFYKFTGMPNLVGQETQFDARHQLQTFKPLITYKCSNKLSF
FLCSVYTPMCDANRHLIGPCRPLCEHVKARCAPVLRVFDIDWPATLNCSRFPVKNGGTMCMEGQDSSEAGDVAVKGRASPSKNKIPTPGPNLL--GRKPG
VEEQASAISCAF-LKKS--TSYVYINRTRCAPLCQA-----HILFHPDAKTLSIIWTSVLSGICSLLTSVTLVGYLIHSSLFRLTERPVIYITLCQLIYS
LGFALSIGLGRETVTCGPDLDSGREIRQEGLDNSVCALVFMVQYFFAIASSMWWSLLTIHWALQYSYSWDKEVIDANQSRFHVLVWLTAGLLTVGVLVSR
QVDADELIPICSVGRQNTRALGVFVVGPETIVTTAGLISLSVGLLFGLFRRRLRRLSTSKRERSDPLERRIGLFCLLYLLPALCVTMCDLYEYLCRDLWL
RDTEHKPIDST----STLSFPPKMPNPDIFMLRIFMSLVPGITCSLWTWSVKGCKPWTRLFTRVRSAVKK----
>tr|A0A0R3UKZ1|A0A0R3UKZ1_9CEST Uncharacterized protein OS=Mesocestoides corti PE=4 SV=1
-------------------------------------------------TRIEIPECKNRFYNFTAFPNLVGQETQMDARHQLQTFKPLITYKCSNHLAF
FLCSVYAPMCDVNNHLIGPCKPLCERVRKRCSPVLKIFNFDWPANLNCSRFPEKNGGTMCMEGDVPSGKTSGSN-----GAQD-LPE-GIGDK--G--NG
IAKEETPIACSH-LIKP--TSYVFINRTRCAPHCMA-----DILFSPNAKTLATVWTSVISGLCLLATTCTLLSYAIQPSLFHTLERPVIYIAGCQLAYA
LGFALRLKLGRKAVTCGKDPASGFAIRQEGLDNSNCALVFLIQYYFFTAGALWWAMMVIGWALRSALGRRHCITD------HVVAWLTPGLLTVGVLVSR
QVDADELLGICSVGRQNTKAMLIFVLIPQMVFLAVGVCAFVYCIVCLVKLRRAWKQDGS---FWDSLSTRLAFFSLLYVVPAISVLACDFYEYLYRDTWL
AGDPMSALSRI----IKTTQSA--ITPEVFLLRTFMSLVTGFATCLWLLSVKGIEPWRRLGRQIENRCAG----
>tr|A0A0R3TV40|A0A0R3TV40_HYMNN Uncharacterized protein OS=Hymenolepis nana PE=4 SV=1
-------------------------------------------------TRIEIPECKNLFYNFTAFPNLVGQESQIDARHQLQTFKPLITYKCSNHLAF
FLCSVYAPMCDVNNHLIGPCRPLCERVRKRCSPVLKIFNFDWPANLNCSRFPEKNGGIMCMKGDIPTPNKKEDYEP---PGRE-LPN-NPSTF--G---G
NDREEAPIACSH-LSKP--TSYVFINRTRCAPHCTA-----DVLFSPSAKTLATVWTSVISGLCLIATTGTLFSFAIQPSLFHTLERPVIYIAGCQFAYA
LGFALRLKLGRKAVTCGKDPASGFAIRQEGLDNSNCAMVFLVQYYFFTAGALWWAMMVIGWAARSTHGNVRNQMD------HVVAWLTPALLTVAVLVSR
QVDADELLGICSVGRQNTKSLLIFILIPQSIFLLVGLFSFASCIVQLFKIKRAQRQDAS---VWDSLSTRLGFFSLLYIVPAVTVLSCDFYEYLNRDKWL
AGDPLNVISRI----IKVTDSPLAITPEVFLLRTFMSLVTGFATCLWMLSVKGIEPWRHLIRQLENRCAG----
>tr|A0A068X087|A0A068X087_ECHGR Frizzled OS=Echinococcus granulosus GN=EgrG_000085700 PE=4 SV=1
-------------------------------------------------TRIEIPECKNLFYNFTAFPNLVGQETQLDARHQLQTFKPLITYKCSNHLAF
FLCSVYAPMCDVNNHLIGPCRPLCERVRKRCSPVLKIFNFDWPANLNCSRFPEKNGGVMCMKGDIPSSSGTEGKDGTVSAGKE-IPD-TMNAL--GGSGG
ITREETPISCSH-LSKP--TSYIFINRTRCAPHCTA-----DILFSPSAKTLSTVWTSVISGLCLLATTGTLLSFAIQPSLFHTLERPIIYIAGCQLAYA
LGFALRLKLGRKAVTCGKDPASGFAIRQEGLDNSNCALVFLIQYYFFTAGTLWWTMMVIGWASRSTHGVIRHAID------HVVAWLTPGLLTVGVLVSR
QVDADELLGICSVGRQNTRAMLIFVLIPQLLFLIVGLLAFAWCIIQLFKIRRSFKQDAS---VWDSLSTRLGFFSLLYIIPAVTVLACDFYEYLNRDKWL
AGDPMSAISRI----IKAASSA-SITPELFLLRTFMSLVTGFATCLWILSVKGIEPWRYLGRQLGNRCAG----
>tr|E0VGP6|E0VGP6_PEDHC Class D atypical G-protein coupled receptor GPRsmo1, putative OS=Pediculus humanus subsp. corporis GN=Phum_PHUM190020 PE=4 SV=1
-----------------------------------------------ECTSSN-LTCVPLPYSDISSDVVVDFKNFHNLQQELNKWEILRKVKCWQTLQP
FLCALYLPKCEYDTVYLL-SQERCKYTMSTCKILKEPLFAATFPSINCDATEFFPR--TCKN---------------------DVKDLRSNLS------G
--E------CISPL-IATDDSY-YDVVNGCGIQCED-----PLITKNEYEQIHKM-IGWGATASLFCNLFTVVSFLIEWRSGNYPAVIIFYINICFLLSN
LGWLAQFLPKAREDIVC--KKDMTLRRSEPSANLSCVVIFVVIYYFLMAACVWFVIFTYAWHLSCGLAKIQERIDKKGAYFHLVAWSLPVVLTITVMASR
QIDGNSMAGICFVRSSYWGARVVFLLVPIAVTILMGGYYLVRGLSFLFNVKKDSQQSDKASAKIREMIVRIGLFSVFCLTFVIVTFMCHIYEFAHEEDWQ
KSF-----RNY-IFCSIL-SSQMRPSIAMIQLHLLIIFAAGIVMSSWVWISSTAETWRRFFNRKI---------
>tr|J9JQY5|J9JQY5_ACYPI Uncharacterized protein OS=Acyrthosiphon pisum GN=LOC100160159 PE=4 SV=1
-----------------------------------------------RCLDMHSLSCVKLPYTSTSTDLVPDET-PEEAQERLHYWQGLKKVKCWAAIQP
LLCALYMPNCENSSLHLP-PQEMCKLIENHCQILKI--ENSWPAEFNCENDTIYPAK-LCKN---------------------DLRELKFNSTA-----G
--R------CESPL-VQTYEAYHYPNFEGCDLQCYD-----PLFSMDEHRQIHNL-IAWTATIAGLCNIFAILTFMIEWQSLNYPNIVILYINICFLFIC
FGWLSQFWSGTRDDIVC--RKNGARKTSEPSDDLSCVINFVFSYYFLIAAFIWFVIFTYSLHTTFSFGKIQEKVDKKGGYFHLLAWSIPLVFCVVVMVLG
EIDGDSVTGTCFVGVNNKIYSIIFVLIPVLISVLIGLFYLVRVLFGLLALKKESTQSKQAKSKIHSAAIKVIMFMILIVVFVSSMFMCYIYEYNNDHLWK
DSL-----RKY-IVCKLGIIPRIKPSVSKKQLYILVLFGNAVLMSFWVWTNQIGNAWCECLIRWL---------
>tr|A0A023F248|A0A023F248_TRIIF Putative cysteine-rich domain of the smoothened receptor (Fragment) OS=Triatoma infestans PE=2 SV=1
-----------------------------------------------KCEPLNYTTCVKLPYAWTSLELVDGAS-QEQGQEQLREWRRLVHIKCWAVIQP
FLCALYMPKCDDHGIYLP-SQEMCKMIMGPCRILVS--YEPWPAVFRCDNQTRYPP--MCKN---------------------DVRELKFNTT------G
--R------CLEPL-VQTDAWY-YDGVDGCGVQCHD-----PMFTDHQRQQIHKL-VAWGASICALFNLFTIVTFMIDWKFSSYPALVIFYINFCFFIVC
IGWLAQFLPGGREDIVC--RKDGTLRTAEPSANLSCVVVYVMVYYFLMAGIAWFVILTYAWHISLALGKIQECMEKKGAYFHLVAWSLPLVLTITTMALG
EIDGDAVTGICFVGSANKEYRAGFLLLPVAAALFVGTYFLSKGLVTLIRLQVDSKESERASNKIKETILRMGVFSVLILVLGATTFICHIYQFKNADLWT
KSF-----RIY-VLCKLGIGEKMRPSVAMLQLHVLSLFSVGVLMSSWVWTHTTFNTWTTLIARLL---------
>tr|A0A0K8S5C7|A0A0K8S5C7_LYGHE Uncharacterized protein OS=Lygus hesperus PE=4 SV=1
-----------------------------------------------KCEFMNYTTCTKLPYNYTSLDLVDGST-QQQAQEQLNEWQRLIHVKCWAVIQP
FLCALYMPRCDSPVVSLP-SQEMCKMIQGPCRIVTT--YEQWPSVFRCENNTRYPT--MCKN---------------------DVRELKFNST------G
--Q------CMSPL-VPTDSWF-FEGVEGCGVQCND-----PMFPDHDRQYIHKM-VFGAASLCALFNLFAVLTFMIDWKFSSYPALVIFYINYCFLMVC
LGWLAQFVPGGREDIVC--RKDGTLRLGEPSANLSCVIVFVMVYYFLMAGVAWFVILTYACHISLALGKIQECMEKKAAYFHMVAWSFPLVLTIATMALG
EIDGNSVTGICFVGYANDEYRAGFLLVPVAIALAVGTAFLFKGLFTLIRLKVDSEDSPRASSKIRETIFRMVVFSFLILIFGGITFTCHIYEFMNNEKWA
KSF-----RIY-VLCKLGFGPRMRPSLAMLQLHILSLFASGMLMSTWVWTRTTVNTWSRFFARLL---------
>tr|A0A0P5SNY3|A0A0P5SNY3_9CRUS Class d atypical g-protein coupled receptor gprsmo1 OS=Daphnia magna PE=4 SV=1
-----------------------------------------------KCQPIKTNICTKLPYSQTSLELVTDHT-QDDVQDKLMFWQNLKSVKCWAVIQP
FLCALYMPRCENGTVELP-SQEMCKVIRNPCRIVELEQRGGWPDFMRCEDTEKFPS--GCKN---------------------EVRELKFNIT------P
--K------CQSPL-VETDLAY-VEGVDGCGLPCNS-----PLFTKEEHEQVQRF-TQTLVAMCLTTNLFAVFTFLIDWRSASYPAVIIFYMNVCFAAAC
IGWIAQYIPSARQDIIC--RKDGTARVSEPSGTLSCVVIFILIYYFLMAACVWFVMLAYSWFVSFALGKIREKVSSKAAYFHLVSWSIPLVLTITCMALA
QVEAQSPHGICFVANSN-VVRSGFVLAPVLILLFVGHVFLYRGLLILIRLKLGSAASASANSKLRNTIVRLASFSISIIGSVVLTFVCHIYEFERRSQWK
TSF-----RSY-MVCLANQQNELRPSMTITQVHLIAVFGAGVAVSSWVWTKASVLAWRRWYRRTF---------
>tr|E2AN13|E2AN13_CAMFO Protein smoothened OS=Camponotus floridanus GN=EAG_05720 PE=4 SV=1
---------------------------------------------------------TKLPYSFTSLDLIPERVTQDIIEEKLYSLQALKHVKCWAVVQP
FLCSIFMPKCV-NNTVELPSQEMCRMVSGPCRMLINHT--IWPSFAKCDNTKLFP--RLCKNFNITG--------KCLKPL-------------------
---------------VPTDNASIFDGVEGCGTECYD-----PLYTSDEHNQIHSF-I-VWAGICCSFNLFTVITFLIDWRSAKYPALVIFYINGCFLISC
IGWLIQFTPSGREVIICR-KDGTLRMREPSGENLSCVVVFVLVYYFLMAAMVWFVILTYAWHMALGT--IQDRINKKSAYFHLIAWCVPLVLTVAIMALG
RIDGNSMTGICFVGYADH-AAKAFVLGPVLIVVLVGGYFLCRGLYTLIRLKEIISE--RASSKIKQTIVRMGLFSIATLAAVVVTFYCQIYEIQHSWEWR
QSFRCAITTMYASDCKIE----MRPSTGKLQLHLLALFATGILMSSWVWTSSTVDTWCRFLRRVFN--------
>tr|F4WKG2|F4WKG2_ACREC Protein smoothened OS=Acromyrmex echinatior GN=G5I_06159 PE=4 SV=1
---------------------------------------------------------TKLPYTFTTLDLIPEHVTQDIVEERLYLLQALKHVKCWAVVQP
FLCSIFMPKCI-NDTVELPSQEMCKMVSGPCRMLMNHT--IWPSFAKCDNKELFP--RLCQNFNISG--------KCLKPL-------------------
---------------VPTDNVSIFDGVEGCGTQCYD-----PLYTPDEHNQIHSF-I-IWASICCTFNLFTVLTFVIDWRSAKYPALVIFYINGCFMVSC
IGWLIQFTPGSRDVVICH-KDGTLRTREPSGENLSCVIVFVLVYYSLMAAAVWFVILTYAWHMALGT--IQDRIDKKSAYFHLIAWCIPLVLTVAIMALG
RIDGNSITGICFVGYADH-MAKIFVLGPILLAVLIGGYFLCRGLYTLICLKEIISE--RASSKIKQTIVRMGLFSIGTLAAVVITFYCHIYEIQNSQQWQ
KSFRCTIASKYASECKMD----SRPSTGKLQLHLLALFSTGIFMSSWIWTSSTVDTWCRFLRRIFN--------
>tr|A0A026VTV1|A0A026VTV1_CERBI Protein smoothened OS=Cerapachys biroi GN=X777_16480 PE=4 SV=1
---------------------------------------------------------AKLPYSSTTLDLIPGGVTQDVIKDKLHQLQTLKHVKCWAVVQP
FLCSIFMPKCV-NDTVALPSREMCKMISGPCRLLLNHT--IWPSFIRCDNAELFP--QSCKSFNTSG--------ECLKPL-------------------
---------------VPTDNASIFDGVEGCGTQCYD-----PLYTFDEHTQLHSF-I-VWAGICCAFNFLAVVTFLIDWRNAKYPALVIFYINGCFMVSC
IGWLAQFV-ASRDAIICR-KDGTLRTKEPGGQNLSCVITFALVYYFLMAAMIWFVILTYAWHRVLGK--IKDRIDKKSASFHLIAWCLPLILTVMIMGLG
EIDGNSVMGICFVGYTNH-VVRAFVLGPIVLGALIGGCFLCRGLYMLICFKEIISN--KLSSKIKHILIRMGVFSSLIIAAVVVTVYCHVCEMIYSWQWK
QSFRCKITTKYSSECKMS----VRPSTGKLQLHLFALFSTGIIMSSWVWTSSTVDAWLRFLKRAFT--------
>tr|A0A026WDQ6|A0A026WDQ6_CERBI Protein smoothened OS=Cerapachys biroi GN=X777_06037 PE=4 SV=1
---------------------------------------------------------TKLPYSTTTLDLIPESVTQDIIEERLYLLQALKHVKCWAVVQP
FLCSIFMPKCV-NNTVELPSQEMCKMVSGPCRLLLNHT--IWPSFAKCDNAKLFP--RLCKNFNTSG--------KCLKPL-------------------
---------------VPTDNASIFDGVEGCGTQCYD-----PLYTSDEHSQIHSF-I-AWAGICCAFNLFAILTFLIDWRSAKYPSLEIFYINGCFMVSC
IGWLAQFA-GSREVIVCR-KDGTLRMGEPSGENLSCVVVFVLVYYFLMAAMVWFVILTYTVHSALRK--MGDRIDKKGAYFHLIAWCLPLVLTVTIMALG
EIDGNSVTGICFVGYVNH-MVRVFVLGPVFVVVLVGGYFLHRGLYTLICYKEIS-K--EMSSKIRHNIVRIGVFSMSVLAAVIVTFYCHVYEIQYSWQWK
QSFRCAITTKYSSECKMD----VRPSMGKLQLHLFALFFTGILMSSWVWTSSTVDTWCRFLRRIFK--------
>tr|A0A0L7R8D6|A0A0L7R8D6_9HYME Protein smoothened OS=Habropoda laboriosa GN=WH47_11792 PE=4 SV=1
---------------------------------------------------------TRLPYTTTTLDLIPEHVTQDNTEEKLHVLQALRHMKCWAVVQP
LLCSIFMPKCI-NDTVDLPSQEMCKMVSGPCRIVFNHT--IWPSFVKCENTELFP--RLCKNFNISS--------KCLKPL-------------------
---------------VPTDNAAIFEGVEGCGTQCND-----PLFTPDEHKQIHSF-I-AWAGICGSFNLFTVITFLIDWRSAKYPALVIFYINCCFMVSC
IGWLAQFTPGSREVIVCR-KDGTLRMSEPSGENLSCVVVFVLVYYSLMAAMVWFVILTYAWHMALGK--IQDRIDKKGAYFHLIAWCLPLVLTVTIMALG
EIDGNSVTGICFVGYTNH-AVRAFLLGPVLIVLLVGGYFLSRGLITLIRLKEIISE--RASSKIRETIVRMGLFSIFTFAAVVVTFYCHVYEFQHSWEWR
QSFRCAITTKYLSECKME----VRPSAAKMQLHLLSPFFAGILMSSWVWTGSTVDTWTRFLRRTFN--------
>tr|K7IPU4|K7IPU4_NASVI Uncharacterized protein OS=Nasonia vitripennis GN=LOC100118295 PE=4 SV=1
---------------------------------------------------------ATLPYDTTSLDLMPKYTTQEMIMEKLHILRGLEHIKCWAVVQP
FLCSLFLPKCV-NDTVDLPSQEMCKVVSGPCKILLNHT--IWPNFIKCDNEELFS--RSCKSFNTSS--------SCLYPL-------------------
---------------VPTDNAAIFEGIDGCGTVCSD-----PLYKPEEEKQIHSF-V-FWAGLCGAFTLFAVVTFLIDWRSAKYPALAVFYINCCFFVNC
IGWLAQFLPGSREVINCR-KDGTLRMSEPSGD-FSCLIVFILVYYSLMAAMVWFVILTYTWLMALGK--IQGRIDKKSAYFHLLAWFLPLMLTATIMALG
EIDGNHTTGICFVGYNNH-TVRAFVLAPVLTSLLIGGYFLSRGLILLIRLKEFLQE--QASSKIRETIVRMGLFSLFTLVAVLVTFYCHAYDFEHSSEWK
QSFRCSITSKYASDCKKE----PRPSAGKLQFHLLSVFFSGILMSHWVWTGSTADTWMRFLRRTCN--------
>tr|E2B9T9|E2B9T9_HARSA Protein smoothened OS=Harpegnathos saltator GN=EAI_16975 PE=4 SV=1
---------------------------------------------------------MKLPYTHTTLDLIPEHVTQNIVEERLYLLQALRHVKCWAVVQP
FLCSIFMPKCV-NNTVELPSHEMCKLVLGPCRLLLNHT--IWPSFAKCDDTELFR--RSCKNFNISG--------KCLKPL-------------------
---------------VPTDNASIFDGVEGCGTQCYD-----PLFTPDEHKQIHSF-I-AWAGICCAFNLFTIITFLIDWRSAKYPALVIFYINCCFMVSC
IGWLAQFTFG-RDVIVCR-KDGTLRMSEPSGETLYCIITFILVYYSLIAAVVWFVILTYAWHMALGK--IKDRIDKKGAYFHLIAWCLPTVLTVTIMTLG
EIDGNSVTGICFVGYANH-IARAFVLGPVLIGLLIGGYFLSRGLFTLISLKEVMSE--RASAKIRETIIRMGLFFIFTLAAVGVTFYCHIYEFLHSWQWR
QSFRCAITTKYLSECKMS----IRPSAGKMQLHLLAPFFAGILMSSWVWTSSTVDTWSRFLKRTFN--------
>tr|B4LU52|B4LU52_DROVI Uncharacterized protein OS=Drosophila virilis GN=Dvir\GJ24666 PE=4 SV=2
--------------------------------------------RRGHCLEVTHNTCSKLPYALTSL-SLTDYRREKELDEALSSYYALRHVKCWAVIQP
FLCAVFKPKCEEIDMVYLPSYEMCKITLEPCRILYNTTF--FPKFMRCNEFPMK-----CSN----D-----------------AREMKFNVT-------
-G------RCMPPLVPADNAASYYPGIEGCGVQCKDP-----LYTNDEHRQIHKL-IGYGGTLCLLSNLFVVATFLIDWQNAKYPAVIVFYINLCFLISC
FGWLVQFTSGSREDIVCR--KDGTRHSETAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHDRIDKKGSYFHLVAWSLPLVLTITTMALS
EVDGNGIVGICFVGYINHPMRAGLLLGPLCGVILIGGYFITRGMIMLFGLKHFANDSTSASNKIHLIIMRMGFCALLTLIFILVAIACHVTEFRHSAEWA
ESFRYIICRISSVFDENSACIENRPSVGVLQLHLLCLFNSGILMSTWCWTPSSVETWKRYIKKKCG--------
>tr|N6SS79|N6SS79_DENPD Uncharacterized protein (Fragment) OS=Dendroctonus ponderosae GN=YQE_12680 PE=4 SV=1
--------------------------------------------RDAECQPLETTKCAKLPYQSTTL-DLIDLASQAKVQEKLQIYQYLRYIKCWAVIQP
FLCALYMPKCEN-GQVDLPSEQMCKITMKPCKLIYNSSV--FPEFFNCEEFPPK-----CKN----D-----------------IHEMKFNIT-------
-G------HCMNPLIETDKPDWWFKDIEGCGLDCKNSS----KYTSNEHNQIQKL-ILYCALLCIILHVFAITTFAINWKTARYPAKGIFYVNVCFAISY
GGYLMQFLADTREDIVCK--KDGTRKSESATENLSCVIVFFIIYYFLIAGLVWFMIFAYAWYMSSLQALAKNKVNKRRAYFHLLAWSLPLILTITTMAIG
EIDGDYITGICFVGFENMMARVGLFVAPLCATVLLSTYIIIRGVILLIKLKIESRESQHSAQKIQSNIMRMTVFTIFMLMFCIVTIGYHVHISMNRQLWH
LSLEYIVCKLTSFSTDYPHCQLERPSLAMLQLYLLAVFGQGIAMASWVWCDATLHAWGRYIRKKFH--------
>tr|D6WXL7|D6WXL7_TRICA Smoothened OS=Tribolium castaneum GN=smo PE=4 SV=1
--------------------------------------------KPAKCQLLNYTTCMKLPYFSTTL-ELTDLTTQEKVQEKLHHYKYLRFIKCWAVIQP
FLCALYMPKCEN-GKVDLPSREMCQLTLKPCKMFYNSSI--FPKFLNCDEFSSN-----CKN----D-----------------VQELRFNTT-------
-G------FCMEPLVKTDNQNWFYPDVEECGLRCKDS-----LYTENEHYQIHKL-IGYCVLVCGLFNFFTIVTFIIDWTTAKYPALSIFYMNICFFISY
SGWFIQFLSDTREDIVCK--KDGTRKSESATENLSCVIVFVLVYYFLIAGMVWFVLFSYTWHMSCVQALGKERVDKKRVYFHLIAWSLPLMFTITTMAVG
EIDGDYVTGICFVGIFNFAARAGLLLAPLAVTMIVAGYIIVRGLVLLIKVKIDSRESEHSSRKIRSNIVRMGVFTLFMIVFCIITFIYHGYVFVNSETWN
LSLQYILCKLTSLSSDFSHCQESRPSVAMLQLQLLAVFGAGIAMASWVWCSATLHSWTRYIRKKFR--------
>tr|U5EP59|U5EP59_9DIPT Putative smoothened OS=Corethrella appendiculata PE=2 SV=1
--------------------------------------------RPAKCEELSFKTCSPIPYTSTSL-DLTDSYSQGQTVEKLYSYQALRYVKCWSVIQP
FLCAVYAPKCEKIDMVFLPSLEMCKITLEPCRILYNTSY--FPEFLKCNEFPPK-----CNN----D-----------------VREMKFNTT-------
-G------ECLKPLVPADLPSNNYEDIEGCGIQCKDP-----LYTDDEHRQIQKT-IAWLAGICLVCNIFTIFTYIIDWRNAKFPSLVVYYFNICYMVLC
VGWLQQFLPGSRDDIVCH--KDGTRHSESSGENLYCLFVFILVYYFSIAAMIWFAILTYSWLVSFMSANGNDQYKKKGSYFHLIAWSVPLVLTISIMALS
EVDGNSVLGICFVGYFNHAIRTLFLLAPLALLLVIGSYFSIRGFYICKKHEVMSGKDKGQKTKLHRIIVRMVYTVIIAFIAIVASIICHFYEFNNSEDWA
SHLRYIICRISSTYTDTSICIEKRPSVTILQIHLFCFFIPGIVMATWVVQTATFDSWNRYFRSKLG--------
>tr|Q86PA9|Q86PA9_DROME LD34308p OS=Drosophila melanogaster GN=smo PE=2 SV=1
--------------------------------------------RRARCYPTATNTCSKLPYELSSL-DLTDFHTEKELNDKLNDYYALKHVKCWAAIQP
FLCAVFKPKCEKIDMVYLPSYEMCRITMEPCRILYNTTF--FPKFLRCNEFPTK-----CTN----G-----------------ARGMKFNGT-------
-G------QCLSPLVPTDTSASYYPGIEGCGVRCKDP-----LYTDDEHRQIHKL-IGWAGSICLLSNLFVVSTFFIDWKNAKYPAVIVFYINLCFLIAC
VGWLLQFTSGSREDIVCR--KDGTRHSETAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHDRIDKKGSYFHLVAWSLPLVLTITTMAFS
EVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWA
QSFRFIICKISSVFEEKSSCIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCG--------
>tr|A0A0K8UBW1|A0A0K8UBW1_BACLA Protein smoothened OS=Bactrocera latifrons GN=smo_2 PE=4 SV=1
--------------------------------------------RHGRCERLVNNTCANITYSLTSL-DLTDYQNQDQMLKHLSNYRALRNVKCWAVIQP
FLCSVFMPKCEQIDMVYLPSVEMCRKTWEPCRILYNSSY--FPEFLRCNEFPPK-----CTN----D-----------------VQDMKFNAT-------
-G------SCLPPLVPADSSSSYYPGIEGCGVQCKDP-----LYTDDEHRQIHKL-ISWLGTLCFLANLFVVATFIIDWENAKYPALIVFYINLCFMISC
LGWLAQFTPGSREDIVCR--KDGTRHSETAGENLSCIVVFVLVYYFLTAAMVWFVFLTYTWHLRAV---GNDRIDKKGSYFHLVAWSLPLVLTITTMALS
EVDGNSTVGICFVGYLNHPMRAALLLGPLCGVILVGGYFVTRGMIMLFGLKHFANDSTSASNKIHLIIVRMGVCSIFTLIFILAAIACHVNEFKHSREWA
ESLGFIVCRIAT----EEKCIENRPSIALLQLHLICLFGSGIVMSTWCWTPSSLDTWRRYIRKKCG--------
>tr|W5JQ90|W5JQ90_ANODA Smoothened OS=Anopheles darlingi GN=AND_003339 PE=4 SV=1
--------------------------------------------RPAKCQPIRHKSCATLPYSSISL-DLSDSYSQEEVHDKLYQYNALRHVKCWAVIQP
FLCAVFTPKCEKIEMVYLPSLEMCRITLEPCRILYNTSF--FPAFLRCNEYPSK-----CNN----D-----------------VREMKFNAT-------
-G------QCLKPLVAADLPANYYKDVDGCGLQCKDP-----LYSDDEHRQIHKL-IAWGAGVCLTFNFFTLATFAIDWHNAKYPALVIFYINFCFAISC
LGWLAQFTPGGREDIVCR--KDGTRTSESAGENLSCIVVFILVYYFLIAAMVWFVIFTYVWHMSFKA-IGKDRIDKKGSYFHLIAWSLPLVLTITIMALS
EIDGNSTVGICFVGYLNHPIRAGLLLGPVCCVLLVGGYFLGRGLLTLIRLRISSKESARASRKIHQTIVRMGICTTFIFVFIVATVVCHAYEFRHSASWA
TALRYIVCQIEASFTDDGGCIIHRPSVAILQVHLLCLFASGIVMSSWVWTNSTLESWGRYFRRRFG--------
>tr|Q175G5|Q175G5_AEDAE AAEL006669-PA OS=Aedes aegypti GN=GPRSMO PE=4 SV=2
--------------------------------------------RPAKCEPIRHKSCSSLPYSSISL-DLTDSFSQEQTHDKLYQYNALRHVKCWAVIQP
FLCAVFTPKCEKIDMVYLPSLEMCKITLEPCRILYNTSY--FPEFLKCNEYPSK-----CNN----D-----------------VREMKFNAT-------
-G------QCLKPLVAAESPANYYKDIDGCGLQCKDP-----LYTDHEHRQIHKL-IAWGAGVCLTFNLFTIATFVIDWHNAKYPALVIFYINFCFMVSC
MGWLAQFTPGGREDIVCR--KDGTRISESAGENLSCIVVFILVYYFLIAAMVWFVIFTYVWHMSFKA-IGKDRIDKKGSYFHLIAWSLPLVLTITIMALS
EIDGNSTVGICFVGYLNHPIRAGFLLGPVVCVLFIGGYFLGRGLLTLIKLKISSKESARASKKIRQTIVRMGICTMFTFVFIVSTIFCHIHEFKNTESWT
IALKYIICQISSTYTDVSTCLHSRPSVAVLQIHLICLFASGIVMSSWVWTNSTLETWGRYFRRRFR--------
>tr|E5LCE7|E5LCE7_ANOGA Smoothened receptor OS=Anopheles gambiae PE=2 SV=1
--------------------------------------------RPGKCEPIKHRQCSTLPYSSISL-DLTDSYSQEEMHTKLHQYNALKSVKCWAVIQP
FLCAVFTPKCEKIDMVYLPTLEMCKLTLEPCRILHNTSF--FPEFLKCNEYPSK-----CNN----D-----------------VREMKFNAS-------
-G------QCQKPLVAADLPANYYKEIDGCGVQCKDP-----LYTDHEHRQIHKL-VAWGASICLAFNLFTLATFAIDWQNAKYPAMVIFYINFCFAVSC
LGWLAQFTPGGREDIVCR--KDGTRTSESAGENLSCIVVFILVYYFLIAAMVWFVIFTYVWHMSFKA-IGKDRIDKKGSYFHLIAWSLPLVLTITIMALS
EIDGNSTVGICFVGYQNHPIRGAFLLGPVLCVLLVGGYFLGRGLLTLIRLRISSRQSARASKKIHQTIVRMGVCTTFTFIFIVATAFCHVHEFRHSAAWA
EALRFLVCQIVAAFNDDNGCYEQRPSVAILQLHLICLFASGIVMSSWVWTNSTLESWGRYFRRRFG--------
>tr|W5JW01|W5JW01_ANODA Uncharacterized protein OS=Anopheles darlingi GN=AND_000509 PE=4 SV=1
-------------------------------------------------------------------------------SVEISSLRPIIQSGCSKQSLF
LFCSSLFPLCSPNPRPVYPCRSLCEQVRRDCFAVSAK---LWPDYLDCRLLPQPEKHELCMQ-VGSADAPGGGGGSFVLPSEDLLDL--VGGLPVENSAG
GGGGLGWPPCPTNYSL---------EYDRCVPRCGPA--IDALYS-RTQKDLVEWWTLILSAGCFIFTLMSLVTFWARAGRLDYPDRPILFMVLCYNLLG
LCHQGGDQRLPRTGVLALSPTDGSSTAAAATTVVDCTIYYIIKHYLLLSASTWWLIFALCWYLSTAKQWSSEALERRSGLFHVLAWVVPFAVPIVALLRG
NIQRFELTGFCT--------AIGLAELPALVLLLSGAVLVLLALCALGRLRTGWNQ----RAHLSRVFAHVLTFAVCYLVPAVGAIVCRMLERVEHE---
----LEPCPVAGRCPTAGYFSTL-P----TLLRLALTLLGGGSVGIWLWVRQS---------------------
>tr|E9GI97|E9GI97_DAPPU Putative uncharacterized protein OS=Daphnia pulex GN=DAPPUDRAFT_318256 PE=4 SV=1
----------------------------------------------AKCQPIKNCLTTKLPYSQTSLELVTDSHTQDDVQDKL-MFWQNLKVKCWAVIQP
FLCALYMPRCENGTVEL-PSQEMCKVIRNPCRIVELEHRSGWPDFMRCEDADKFPSG--CKN---------------------EVRELKFNITPK-----
---------CQSPLETDNSLAY-VEGVDGCGLPCT-----SPLFTKEEHERFTQTLV----AMCLTTNLFAVFTFMID--------VIIFYMNVCFAAAC
IGWIAQYIPSARQDIICR--KDGTARVSSGGETLSCVVIFILIYYFLMAACVWFVMLAYSWFVSFQAGKIREKVSSKAAYFHLVSWSIPLVLTITCMALA
QVEAQSPHGICFVANSKV-VRSGFVLAPVMILLCIGHVFLYRGLLILIRLKLAASISASANSKLRNTIVRLVSFSASIICALGLTIFCHVYEFDRRNQWK
TSFRSMVCQGLADDCELESR----PSMTITQVHLIAVFGAGVAVSSWVWTKASVLAWRRWYRRT----------
>tr|E2FMT3|E2FMT3_PLADU Smoothened OS=Platynereis dumerilii PE=2 SV=1
-------------------------------------------------------------VNQTCLGAKLTHTSIEMVGLEVFNNLRLRNVRCWDVIQP
FLCGIYLPRCVGSK-VDLPSQEMCERTREPCKVVEKK---GWPDFLKCDQP-HFISG--CDSQVT--------------------------KLRFNTSSG
R--------CESPLVKTANKGSWYQDVDGCGIQCQN----P--LFTDSEHNEVHHIIGTFAALCMIATAFALLTFIIDWRNASYPSLILFFINACFFIGS
IGWAAQFIPGARDEIVCR--KDGVRTQEQGGESISCTVVFILVYFSMMAGLTWFVILTFSWNLTIGS--ISDVLESSKAHFHVVAWSIPLVLTIVCLALT
QVDGDSVSGICFVGYMNHYYRAGFVLTPVGVAVVVGVGFLGHGLYTLQQLSQEGLISNKARTKIRGTIKRLGIFCALALSFATFIVHIYIFV--NEPTWE
KAFVCQTLAKEIEPCILE----SRPSLVALEIHILAFFLAGITMSSWVWTRATLDAWHRFILR-----------
>tr|T1ISZ0|T1ISZ0_STRMM Uncharacterized protein OS=Strigamia maritima PE=4 SV=1
----------------------------------------------AQCENLHSNLCFGIAYKQTSLSLLGSSMNQSEVQRQMQLWAGLSSVRCWSVIRP
LLCAVYMPRCENGSIDL-PSYDLCRITRKRCRIVE--VIENWPEFLKCDKPHFK---HQCKNEWREV----KFNSSTARCAAPLV-----------NSDH
E------------------LS-WIDGVEGCGLPCNN----P--LFTDAEHHHLRSFIIIVGSICLSCSLFAVVTFLIDWKSVKYPGLIIFYINFCFLIVN
IGWMAQFTPGAREDIVCR--KDGTLRLREPSENLSCVIIFIMVYYFVMAAVIWFVFLTYSWLMSFR-NLGRDSVVSKTAYFHLAAWCLPFVLTLTVLALG
QIDGDSESGICFVGSVNMWFRIGFVVLPIFSAACVGGFFLVQSLQILIRLKI-ESADVINNARINTTIFRLVTFFVIFLVHVTI--GCHLCE-ALRNANH
SDTQEKTCELTSRP-------------SVHMAQIIAIFVCGIVMSSWVWTEATVETWKRFFRRLLRKPV-----
>tr|A0A0P4WL15|A0A0P4WL15_9EUCA Uncharacterized protein OS=Scylla olivacea PE=4 SV=1
-----------------------------------------------ECVPLEETTCLGLPYTHTSL-ALSGFPNQRMARLEVWS--ALRNIRCWAVVQP
LLCAVFFPQCNNSSVEL-PSQEMCVITRGPCRVVEKE--KRWPEFLKCHEYP-HK----CK--NTVR-------------------ELKFNTT------G
--------QCTPPLVATEEDSSWYEGVKGCGVQCA----NP--IFTDEEHKDLHSFVATLGGVCLACSIFTVLTYLIDWRAAKYPVLIIFYINGCFLVAS
IGFMVQFHPGVRQTCR---S-DG--TLREGEPSSSCVVVFVCLYYFMMAGGLWIIILAYSLFYAAGLC-G-DELERRAAYFHLVSWSLPLVLTITIMALA
QVEADSVAGICFL--SSALPIRVFLLLPIIIVVIVGGFFLVRGMIKLIHLKMII--SDSANNKIVETIIRLAIITVTLTTFTGITVYCHIYQYRNQAHWD
KALRNIMCVTATSVCTIS----DRPSINIYKLHLLAFFGAGIIMSSWCWTPNTIQAWKRFLRRVAGVSSEE---
>tr|A0A077SP38|A0A077SP38_9METZ Frizzled C SciFzdC OS=Sycon ciliatum GN=FzdC PE=2 SV=1
--------------------------SSTVQCQ-YTPGKDLS---HRACRTFDVPLCYRIGYNRTRWPNTLEENLPLVVNKRLDDMKPLVQTHCHPWLFA
FLCFIHVPHCTPISHVVGPCRQLCELVRDACLPYIRAFNMTWPDHLDCSKLISHP-GQ-CFMHSHSNET----VIPTGWDIGPHFSDIPPTALPT-----
---TTFTATCPGGSAVDK-SWYRFGGQRYCGQSCTRD----TMY-TERDRDVIMLAIAILSVL---ALLISLVSFVADLKNFLSPEWGVLLINVCGMVAG
ITQVTTKLIGHNQSC-DSTSD----AVYQGMGGEACLLTFFLTYFTGVLALFTWFKLSVFWLVTV-MA-TRKTIRKIDTYLTIPVWLVPTALTVAVFLLQ
KIDGGLLTGACSVGSYNINALLNFVICPVSFCLFVGWRVLLLALASPRSNATAAQAAGLGDEQYRLRFERIGKFCVLLLVPAVGYLTTLLYEYVEQDEWQ
LT---------AVACAPGCTGGRHPLLSVFGIRYFMALLIALI---CLWYKNLFCSWLPCV-------------
>tr|A0A0K2ULM4|A0A0K2ULM4_LEPSM Protein smoothenedlike [Apis florea] OS=Lepeophtheirus salmonis PE=4 SV=1
----------------------------------------------------------------------------EDAELGLLESWTYLKPKCWSSLRP
LLCSLYAPECSPITNTLGVPKALCKALKGPCRALKQELQSQWDRAFMCRGK------SFCEREI----AGGT-RDILKFPES-----------H----EG
--------VCYKPLVQNPANYFKFI--DGCGLQCFPPDKTPEQYGKIQS----LIGIGVLAALS--TSSFATATLILDWKSSSYPNRIIFYINLCGLLFI
SGWGLPFLQGDNSVCN----PDNTRRVQEGEQDLACVALFVLIYYFGLSSALWYAILTFSWNSSMGLLSQREILLKRTPYFHMIAWSVPAVLAIAIISLN
GVEGDPLTGICFVSKSSPSFYFGFVIAPIAGICVISTFFVVSSVKSLVLAKSAIEIAGARSRRIRSTTVKIVIYSCIYF-------TCFFI-TVFSSVWI
EERNEAILKMYLG-GEEFHKP-LK----YSEIVILPTFLSVIASASWVWNKNTFKSWRKFFRRRFNSSE-----
>tr|A0A0B5CME8|A0A0B5CME8_9METZ Frizzled B OS=Oopsacas minuta PE=2 SV=1
----------------------------------------------QLCEQIRVPYCANLT-------N-FHRETIQEAEFILSKYESL--FNCSDEMKY
FICSALLPSCEN-SQLKYPCNSFCRRISESCQNELREIGNEITNIFNCDVLYQESS-NQCIRQPMEAQTINIH---------------------------
-------------------TNNTQTHTNNSSPFCED------THYTIAAKHFASTWLVITTIPTILILLFTLLTILINLKAYEYPLQPILYIVLSHVVYC
IGVLFRSAIGYYVSCQNGEII---RGEFWTLEHAPCIIIFITTYFGMMSYLVWTCILTICLVFSKLFQWSDADVAKFRVVFHSLGWSIPTAQTLILMSIR
ESRTDELTGICSVHVQSRTTYIAGFILPIVVYTIVGIVLSLFGIIRTYT-RMGFYQKHLEKHTLIRSIIRISIFLFAYTSIFAVFIITTTYDYIAYPSYT
E----VSCKG--VNCRM-----ASP--AVGIVTITCILTSGLVSTIWIARTSTYTKWKRTLLKLTRRKRN----
>tr|D2ILS1|D2ILS1_SCHMD Smoothened-like protein OS=Schmidtea mediterranea PE=2 SV=1
----------------------------------------------SECQLLENSTCFNIKFTFMTFPNTN----F----LDINYWSAVKSIKCWKYLQI
LLCSLKYPECQKRWMINKPFRKICEITKQECSILIVNNNEKTPSFLDCNKYPQN-----CPADSFKL---------------------------------
---KNDLYQCQLPTVYTDQRSLWIKGIDGCSFPCRT------PFFSNDEYNLTKSLFGYVGIIFFLLNLIVLITFGFHQYLSVYKWHPMLFIIHIYLISS
IGWMMQFIPGQSIVCRSDGAVQIREPQVQIGESKWCVLVFSMIYFSLFASSLTSLTLSVTKQ--YSRFWAHTKIRNHSLSSQLFVVLISAALLIISLTIG
EIKGDPLSGICFISTDYMVVRICLALLPLTIILIILSIIINIGHLKLI--QKHLNVYATNQNRMNKTVTFYIFIIILLWIFWSFSIYTHTYIYSHEKLWY
KALKKQLCRLKITRCPL----ESKPSINVFILHNFSYFSLNFIFVLAIFNKSSFLIWKSQFLKLF---------
>sp|Q54PA5|FSLK_DICDI Frizzled and smoothened-like protein K OS=Dictyostelium discoideum GN=fslK PE=2 SV=1
----------------------------------------YPIDPTGKCEQYVITPCNSI-YVS-------STANQSTAMLSLNLYFSLLGASCQAYTFA
TLCSTYLPECEIFAMPKRVCLDTCNSVSKNCQIT---------SYFDCNQFPKESSRLDCYDPPKSNET-------------------------------
----TVIGYCPFPLVFSENYGYTYVEDSYCTIPCPA------PIFSEKQWDNIFDTSDAISLVSLLCSVYLFITYMVNPKRNK-YDYFFSFFVLSIILMS
IAGTIGFSGGTKLLCPEIN-----RRGVY--TDPAVAAAGWIFQFAIINAILWFSINSFELWFQIKF--IKRKLH-LIKFYILAVLVISIALSVPLSAIG
EFNAGLGNFVVWIESGKY--QNWFFWGPLGIVLTVGTTFIGLVIWEIYKIVSSTNK-----SDFFKLQLKPLMNMLLIYLTFVYLFGYNFYIHNSLNGFY
GSSEFKNCIISTKDCR-----IQGPPYSSILMFVFCLRIYGVYCIALGFSPKTRSIWSNS--------------
>tr|F0ZYD3|F0ZYD3_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_89818 PE=4 SV=1
----------------------------------------YSIDKTAKCEPYP---CDSI-YTT-------ATQTQAGS-KSLSSNVDLLKEGCNINTFR
TACSFLFPKCVEYAFPVLTCNAQCVNTTKSCKET---------GIINCDKFPIKNQTIECNNPYLENGWG------------------------------
---GVEED--CFILKRDEKKGYLFVEKSNCVIPNPV------PLFTDKQWTQLYNLSNVLSVLSCLGALYLFITYNVNPKISQ-YDKMHGFFNFSIFLQS
LSGVIILFGGPSLIHDDGA-----RISVW--EDPLCSSTGFIFQLSSIMAIEWWVLMAFDLWYRLHF--TNKRLN-LMKFYVPFTITLALVFSIVPLATK
NYRMIRGNMHCWVNTTKL--QNGLFWIPLGIALFIGTCFLVGVIIEIYKVVRASKR-----GGVFLLEVKPILNIVLIFFTFLYLFAFNFYMNDQGDIVY
GQIPYFKCVSTSQDCV-----IKGPSIGSLGFFIFCIRIYGVYCFFLGLTPRAKKIWKKS--------------
>tr|F0ZNG9|F0ZNG9_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_153271 PE=4 SV=1
----------------------------------------YSIDPKAKCEKYDIIKCASV-YIP-------GSTTQDQIMVELKMYFKLLGDACQVHTSQ
SLCSMMLPECQEFAIPKRVCRGTCTDVTGICGVS---------SLYNCSQYPITNTTIQCFDPPQNNQS-------------------------------
----TVVKSCPNPLVYDAELGYVYVNQSYCTIRCPA------PIMSDSDWNSLLRESDALAFISLVCSIYLVITYLINNKKNK-YDYFFGFFTGSILLMS
VAGTMGLFGGAAIICPEEN-----RRAMG--TDKACSASGFLFQFSIANAVLWWCIQSFELWYQIHF--VNKKLE-ILKIYIPVVLVLSLAFSVPILGLG
RYRAGLGNFLCWIDSGTY--QNVFFWGPFAFMLTLGTVFIILVVYEIYKIMKSNSK-----KDIWKLQIKPLLNMILVYLTFIYLFGYNFWIHQNADWFY
GSIVFYTCLLNTSNCF-----IQGPPPSSLKMFAFCLRIYGVYAIILGYNARVCKIWRES--------------
>sp|Q54PF8|FSLL_DICDI Frizzled and smoothened-like protein L OS=Dictyostelium discoideum GN=fslL PE=3 SV=1
----------------------------------------YPIDQTGKCEPYQITKCSSI-YVS-------ANSTQKDSMKTLDNYFGLLLEKCKSLTYQ
TLCSMYLKECESFSIPKRICRKTCNDVTKLCNIE---------SLFNCSQCPLNYSELQCYSPLSNDSIE------------------------------
---IPVTNYCPFPLIYDEDRGYMFVGNSNCVVPNPV------PLYTPKQWDRLYDLSNSLSVLSCVGTLFLLFTFNINKKINR-FDRMNSLFNGSVFMMS
LSGVIILFGGPALIKDGGA-----RISVW--QDPLCSATGFIFQLFSIAAILFWVVMSFELWYKIKF--MTKKLD-LKKYYIPFIIIVSLVFSIIPLATK
NYRMIRGNMHCWVHTTKL--QNSLFWIPLGIAITIGTIFIGLVMFEIHRIVSANSK-----GGVLKLEIKSILNVALIYLTFIYLFAFNFYMNGQEGVVY
GQIEFYQCTLENSECT-----IQGPSIGSLGFFIFCIRIYGVYCFILGLNYRAYNIWKES--------------
>sp|Q556N7|FSLM_DICDI Frizzled and smoothened-like protein M OS=Dictyostelium discoideum GN=fslM-1 PE=3 SV=2
----------------------------------------YPIDPSGKCEQYPSSPCSSI-YVS-------SNATQQNAMKKLDEYFGILGSGCKSLTYK
TLCSIYLPGCESFAIPKRICYNTCNNVTTKCGVP---------KYFSCDQFPLNYSTVQCYGPLSDNTMV------------------------------
---NLDSSYCPPPLFYDYDRGYLFVETSNCVVPNPV------PLYTNEQWDQLYNLSNTLAVLSTFGSLYLLVTFIINPKVTS-FDRMYGFFNGSVFMMS
LSGVILFIGGPALIKDGGA-----RISVF--EDPLCSSTGFIFQLFAINAILFWAYMGFDLWWRVKY--ITKPLN-IQKYYVPIAFTISFIFSVIPLATK
NYRMVRGNIHCWVHKAVL--QNTLFFGPLGLTLTISTGFIGLVIYEIYKIVKATGR-----GGIMKLEIKPILNIVLIYFSFVYIFAFNFHNDNNSKNTY
GSIDFFQCTLESSKCT-----VGGPSIGSLGYFIYCIRIYGIYCFFLGLNERAFKIWKRS--------------
>tr|F4PN10|F4PN10_DICFS Putative uncharacterized protein OS=Dictyostelium fasciculatum (strain SH3) GN=DFA_05033 PE=4 SV=1
----------------------------------------YPIDNGAKCEPYDFNLCQSI-YVG-------SSTNQVEMRSKVEGYFGLIMKECKPNTFK
NLCSFVFRECVKIIVPRRTCQENCKE-SKLCAID---------KMFDCEMLPPSPSSVQCLDTSAS-NLA------------------------------
----KATNQCPYPLVYGYYKGYFFINNSDCVLRCPI------PVFAERDWHKLFVFYDVVSYFSFFGSVFIFITYVGSKFKTN-NERNLALFLTHITIMS
ISGILNTWRGVDFICQSER-----QTITG--DSRFCVFNAFLFQFGAFSASLWFVIMCFEIWYTITH--FTRKLE-LFKYYFVATLFLASLFSFIPLGLQ
TYGYNQGNFMCMISGSNY--AAPLFWIPLGILLSIATIFLFMIMYQIYVIVKATGR-----SI-FKLEIKPMVLVFSFYCSFVYSVFWNYYSEHTKKIAE
EGIPFVECLLMGTDCI-----LGGPTFGMMVAYIFFLRVYGLYGLLIGFNQKCLTIWRKS--------------
>tr|F4Q1M7|F4Q1M7_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslM-2 PE=4 SV=1
----------------------------------------YPIDQGAKCEPYDFPLCGSI-YVN-------STTNQTYLRTQTETYFQLVQQECQTATYI
NLCSFFFLECLNVVLPRRTCQNNCYQAAEKCQIP---------ELFNCSKYPVNGSKVQCLNPLLYVNGS------------------------------
----YNQKSCPLPLLLGGKEGYFYVNSSACVLPCPL------PIFTENQWDSLFTFHDVIAYLSFFGSLFTFVTFACNQFKTA-NDKNLALFLTSIFLMS
LSGVLNNFRGTSFLCPSQI-----RSTSS--EDGMCVFNAFLFQFSALNSAAWWCVIAIEIYYTITH--LTKKLE-LFKYYLAGITIFTLVFSFVPLGLK
VYGYNKGNFMCWIVGGVY--ENVFLWVPLGVALTIASVLIVLVMIEIFKVVRATGR-----GSLIILEAKPMLMVIAIYFSYVYLFFWNYYSDNTKRIYD
TEVPFSQCLFSGSDCT-----LRGPDFGMMAAYVYFLRIYGLYSFFIGFSAKSRKIWKRS--------------
>sp|Q54P68|FSLA_DICDI Frizzled and smoothened-like protein A OS=Dictyostelium discoideum GN=fslA PE=3 SV=1
----------------------------------------KAINSDAFCQKK---ICDSI-YIF-------NSTTTQESIEEILGFFS---STCQPSTYR
LICNQYFQTCVPIAIPLRPCRESCDYGNGICGTQ---------ST-PCTGFPVTSNDLQCLNIDTMKANET-----------------------------
---VIVNQTCVYPLVYDIKKGYQYLETSDCLLPCPV------PFFTENEWYQFKDLTTVTGVISFVCIFFNIFIYGFNKKHDR-HTIGILCLSFSLWCCM
LSDLIVASSPDSLVCPEPG-----RFARI--HDSRCVANGIIFQWGAVCTTMFWSAMAIDLYLVIKK--LSLPAF-TVKYFVAAIFTLALLFTTVPLAWD
DYGYGFGGVGCWIMSNSV--QNGCFWIPMLICLLIGAVSICLIIYEIVKVFKNVGR------SIILANARLFGIVSFIFIEYIYLFVYHFWVQENTEKFT
QNITWVICVQTTCP-L-----PKAVPYATQFIFLFFLRLLGIEVCIFGINSRSKNIILES--------------
>tr|F1A3V2|F1A3V2_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_159333 PE=4 SV=1
----------------------------------------NPIDRSYRCEKY---KCDSI-YVN-------DTDTQKL-ANTVLKFAG--TSDCKLSTVL
FVCNTFFRSCVDVALPIKPCFDDCSLSTGACSVS---------AL-DCSAFPKTENVQQCLDIDTMKANNI-----------------------------
--TGIFPNECTAPLIKDEKLGFQYLPDSDCLVPCPI------PFFSKSEWSSFKHLTTVSGSIAFVCVFFNIFTYGFNTKHDR-HTIGILCLSFSLWICM
VSDLIVASSDDSLVCPEPG-----RFARQ--HDTRCAANGIIFQFGAVNTVMFWSVMAFDLWLVIKK--LSPSRN-MVKFYIIAIEVLAVIFTILPIIWK
QYGYGFGGVGCWVLSDGW--QNGVFWIPLTVCLFIGTSFICLISFEIYRIVRNVGK------GVLKVNIRPFLIILFIFGEYVYLFIYHFYVQHNTTKFT
NNIRWVICLQSKCK-R-----PETIGYASQFIFLFFLRLLGIEVLIFGINTRTKRIWKES--------------
>tr|D3BM93|D3BM93_POLPA G-protein-coupled receptor family protein OS=Polysphondylium pallidum GN=fslA PE=4 SV=1
----------------------------------------YTLDPNATCEPW---FCTSI-YVS-------TSRSQS-VMVQIQSYYN---SQCLSNNRK
FFCNAVFPECKPQNLGVGVCQANCKHVSDLCIPA---------GNEINCDYPPNYNQVQCLNSSSTA-NGT-----------------------------
--LAPINGTCPDPLIHDLDKGYYLLEGIDCLMPCPA------PFFTHSQWSNMRLMISIVSPISFFCISMNLITYVGNRKFDR-HAFGIIFLSFSVFLMT
LSDLIFIAGG-DSICPDPG-----RFARQ--SDSSCAAAGFIFQYGVVSAMLWWASMAFDLWLVIRK--VQNVKS-YVRYYISTINVIAIVLAIVPIFGK
QYGYAVGGLGCWVMDDAW--QNGVFWIPLCVCLFVGISFIFLICFEIYKIVTAVSK-----IRILRMNIKPFIIVLFIFSQFMYCFIYHFYVQDNMDRYY
NNMAYVKCLVSTCASH-----AITVPYKSQITFLFFLRIFGIEILFFGFTKRTKKIWLLS--------------
>sp|Q55CD6|FSLB_DICDI Frizzled and smoothened-like protein B OS=Dictyostelium discoideum GN=fslB PE=2 SV=1
----------------------------------------GLVDPTATCSNYDQPLCNNI-YTS-------KN------ITQYEKTFISLTSKCFNFAEF
GICDIYFPPCFQTSLPQRLCKSACERMVSNCSSL---------GSLNCSDFPRIATPVPCSDPLATFEKST-----------------------------
--TSELIEICPSPLLLSADRGYTYLTPTNCVLPCVA------PIYTEKKWHQMYNMSKILSTISFVCSIYNVLTFGINHRRSK-YNYCITFFSASVIIIT
MMDIVTYGIGYKLLCPEPG-----RFAVQ--SDVSCGATGALFHIGITNGVFWWTTMSICLFAVVKR--IK--LF-DFRYFIIFNTTASLISVIIPLAGN
AFMAGTGSLACWIRKTWY--VNSVFWIPCGIALTIGSVCIILVIYEIYKITKNVST------RMILLQIKPFLCVTLVGGSFYYLFIFNFDNESHSKEYK
EKVVYVMCLLS-KECL-----MAGPNYVAYFVFYFFIRLFGITFFCIGTSQNARDIWIHS--------------
>sp|Q54J71|FSLG_DICDI Frizzled and smoothened-like protein G OS=Dictyostelium discoideum GN=fslG PE=3 SV=1
----------------------------------------GLVDPNGQCMNYDQPLCKFI-YST-------IG----NSLNQTAKSFEALTNQCQLFAEY
GICNIYLSPCIITSLPQRLCNSACQRMVTNCPRL---------GKIDCSIFPEVGTEVPCFNPTADYDSSS-----------------------------
--LNEFIEICPSPLLLS-KRGYTYLPPTNCVLPCPV------PNYTKEKWNQIENLSKVLSTISFVCSIYNILSFGIKKKKTK-YTICISALSASVALIN
LGDIIKIGVGYKVLCPEPG-----RFATQV-DDPLCGLTAALFHVGICSTVLWTTTMAIYLYSAIKN--IK--LF-KFRYFIIFNTGFSLTSLIIAASAS
KFEAGTGSIECWIRDRWY--SICLFWLPCGICLLIGTICIASVIVEIYKVSKNIKL------ETIMRQIKPIISVILVSGSFTYLFIIFFDIERNFGGYR
SAVTYVLCLLNSIECH-----TSGPSYNPYFMFYFFMRFFGILFFLIGTSKNARDSWYEL--------------
>sp|Q54J77|FSLF_DICDI Frizzled and smoothened-like protein F OS=Dictyostelium discoideum GN=fslF PE=3 SV=1
----------------------------------------GLVIPDAECLNYDQQLCNRI-YTT-------TN----SQI---KKSFEAITDQCKLFAQF
GICDIYLAPCIEVSLPQRFCKSVCDRMVSNCPRL---------EQMDCSNFPEIGTAVPCSDPTIFFNVSS-----------------------------
--NSSFIEICPSPLLLAANKGYSYLSPSNCVLPCPV------PNYSNQKWDQLLTMSKILSTISFILSLYNVLTFGINKKVSD-PHKCTCFFSGSIALVN
LCDIITYGIGYELLCPEPG-----RSAKQQ-LDPVCGLTGAFFHLGITYCVLWSMTMGLVLYCSVKR--QK--WF-KFNYFLIGNTTFTITTVVIAAATS
KFEAGLGSIECWIRDRWY--AISLFWIPCGIALLIGSFCIIAVIHEVYKTSKKSIS------DLLQRELKPLLIVIFISGSFLYLFIFFFDIERKFGGYR
SAVEYVLCLLNGEECF-----TTGPSYVPYFLFYLVIRWFGIIFFLFGTSNIARKIWVQN--------------
>sp|Q54J78|FSLE_DICDI Frizzled and smoothened-like protein E OS=Dictyostelium discoideum GN=fslE PE=3 SV=1
----------------------------------------GIVFPGSKCLNYGQPLCNKI-YST-------VTLVDNKNISQELKSFEALTDQCDLFTQF
GLCDLNFSPCVETSLPQRLCKSVCERMVSNCPRL---------SKIDCSIFPEIGTKVPCIDPTDGYNISN-----------------------------
--QMELIQACPYPLLLSPNKGYTYLPPTNCVLTCPM------PNYTKTQWKRVYDMAKTLSSISFICACYNILTFGINRKKSK-YNICITLMSTSIALVY
LTDIIKFGYGIEFLCPEPG-----RSAVQ--NDAACGITGAMFHFGITYCCCWAMTMSIVLFCSVKR--IK--LF-YFRHFMIGNTIFTIITTVILLSAK
KMVAGTGYIECWVRERWF--VITLFWLPCGIGLSIGIFCIGGVIHEIYNISKKVNI------EFILRQIKPFSLVFSVAGSFLYLFIFFFDVERKIDSYK
AAVAYVLCLLSGETCF-----TTGPNYASFFIFYFFIRVFGVLFFSIGTSRVARDIWSEV--------------
>tr|F0ZQZ2|F0ZQZ2_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_56349 PE=4 SV=1
----------------------------------------GLINPNATCSPYDLRICN-I-YTE-------SG------ISQKEAAFTKLTTQCPNFSQF
GFCNLLLSPCETVSFPKRICKSTCTAIVKECNIL---------SYFNCTNFPDLYNPIQCENVTDLFIKTP-----------------------------
--NSQISEVCPPPLLLPAEKGYTYLTPTNCVLPCPA------PYYTEKKWNQMFTMSKIVSTISFVCCIYNICTFGLNKSVSK-YNYCIVFFSASVALIN
LMDIVTYAIGYKLLCPEPG-----RFAVQ--DDVACGVTGSLFHFGVTNGVLWWATMAIYLLSVVKR--IK--MI-DFRIFVLFNTVVSLIMLIIPLSGK
AIMAGTGSLACWIRKTWY--VNGVFWIPLGLCLFIGAGCIILVIFQIYKISKNVS-------KILKLQIKPFLCVTLVGGSFFYLFVFNFDNERHMDEYK
ASIPYVQCLLA-ETCV-----SEGPNFAAYFMFYFFIRLFGILFFCIGTSENARNIWIHS--------------
>sp|Q55DT7|FSLD_DICDI Frizzled and smoothened-like protein D OS=Dictyostelium discoideum GN=fslD PE=3 SV=1
----------------------------------------GIVDESSICTSY---LCKSI-YTT-------PGGGGGGGKLQIQKGFQSLTGICKNFIEF
GMCDSALSPCIETSLPQRVCKSVCERMLIGCPQL---------AQIDCSIFPKIGTMVPCIDTEINYEVQE-----------------------------
--NVGFLESCPYPLLLAEKRGYTYLTPTNCVLPCPI------PNYTKRQMDSVINMSKAMSSISFVLSLFNVITFGLIKKKSK-YNVCIALMAIGSSFIY
LSDIINYGVGIKQLCPEPG-----RVATQR-VDSLCGFTGSIFHIGITLCVLWSMTMGIVLYSKIKQ--FK--LP-NFRYFLIGNLSFTVVTLIILASAK
KFQGGNGFLECWMRDRWY--VVAIFWIPCGIALLLGVLSICGVIFEIYKISKNVSL------KVVIRELKPFVLVVTVSASLIYLFVFYFDSESKYDFYK
KGVEYILCLLTSDECY-----TVGPNFNSYFMFYFLIRFFGILFFGIGTSEIARNAWTES--------------
>sp|Q86J18|FSLC_DICDI Frizzled and smoothened-like protein C OS=Dictyostelium discoideum GN=fslC PE=3 SV=1
----------------------------------------GLVDENLKCLSFNQQLCNLI-YST-------IN------KSQIEQSFKQLTGKCLNFAQF
GICDIYFPSCVETSLPKRLCKSVCKQIVTDCPTL---------GSLNCSDFPTIGTQVECSNPTNYYYNST-----------------------------
--NNQFIEICPSPLVLGEDKGYTYLSPTNCVLGCPQ------PFFKNNKWVQMYKMSIVLSTLSFICSIYNIITFGLSKLKSK-YNLCITFFSVSTVLMS
LMDIVTYGIGYELLCPESG-----RYAIQ--SDVACGVTGAFFHIGITTGVLWWTTMSICLYSEVKR--FK--MI-SFRYIIIFNSVISLILLIIPLSGQ
AFMSGNGSLGCWIRKTWY--ANGTFWIPCGISLFIGAICIVLVIYEIFKISRNLS-------KPLMFQIRPFLCVLLVGGSFLYLFIFYFNNERNLDKYK
AAIPYVQCLLSSEDCL-----TDGPGFGAYFTFYFFTRLFGITSFSIGTSKIARDIWFES--------------
>tr|F4PIF1|F4PIF1_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslJ-2 PE=4 SV=1
----------------------------------------QAIDLGATCQIYDQPLCNSI-YIN-------STSTQESI-QQFGLFVRSNLDSCKPSTFA
FICAYLFPECIEYALQQPACFDDCSETADVCGVG---------GLLPCSSFPTNATLVNCLDTSQI--GS------------------------------
---NSTVQKCDQPLIYDEDLGYQFTGNSTCVVACPA------PIYEYKIWKNLYTLSDILSILSMFLILFLIVTYGLNPKIKR-FDKINLALMTSIFFHA
FSGALQAFNGSKTLCPEPN-----RFASH--TDGVCVASAFILHVASLYVVQWWAVMSFEVLWAIRE--VGKGRK-DWWFYVVGTSIIAWVPPIASIVNN
NYRGGAPNTFCWLSTHTY--QVGAFWVPMGIFLGLGGLFMLGLMREIYIIISANLG-----ADILKLEIKPILSLVMYFSILLYLFIYDQWIQAHKDEYK
AEIPWVNCLTNPTTCV-----IGGPPIASLGYFIYCIRVFGIYAFLIGISKKTVSIWKHN--------------
>sp|Q556J4|FSLJ_DICDI Frizzled and smoothened-like protein J OS=Dictyostelium discoideum GN=fslJ-1 PE=3 SV=1
----------------------------------------FPLDKGATCQKYGIQLCDSI-YIN-------STSSQEAI-QAQGNLVRQYIESCKPRTFA
LLCAFLFPECEKYAYPILPCYNNCLNMTTSCQIS---------TRLSCATFPKNTTTNTCENTDLIANSQ------------------------------
---NTSIQQCFEPLVYDKSIGYIFPTNTTCVVGCPA------PLYYANQWRNIYRLSDVLSILSCILTLFLVITLGINPKVSR-FDKINVMLLSSIFLQA
FSGALMTFNGTNTLCPEDG-----RFASY--IDRMCVATGFLLHGSSLLVVQWWCVLSFEVWFTIFQ--VGKKQK-DFIYYLVASLIIAWIPPIVSISKN
EYSGGPANPFCWLTTFNY--RRFAFWLPMGIFLCLGGVFLILLMREIYVIVSGNVQ-----SKVLKMEAKPIISLIMYFSCLLYLFIYDQWINNHMHVYT
DSIPYALCLLTSNDCL-----LKAPDITGLGYFIYSIRVFGVYAFIIGISKKTLQIWKYN--------------
>tr|F4PMF0|F4PMF0_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslF PE=4 SV=1
----------------------------------------HPVDPTGRCEKYDTPLCQSV-YVN-------STASQSDL-QTQALQFKLILDQCKQNTYK
TLCALFFMECIEYAFPKFPCSANCYNTTELCQIP---------TLLDCSSFPLESASVTCQNPNLI--NS------------------------------
---NTTFGLCPFPLVESTYEGYIYINISSCVAPCPS------PLFKPQIWTNIFTMGDILSFLSFFATIFLIITYGINPKITR-FDKINLCVMSAACGVA
LAGVIQAINGTDSLCPEPG-----RSASP--IDDLCLTTGFILHVSALYVVTWWCIMAFEVWFAIKT--VGAKKR-EFKYYCIGTSLISWIFPIATISAK
EYHAGPGNVFCWIWSSKY--RNIFFWGPLGVFLFAGTIFLILLIREIYIIVSIKIS-----KNILKMEVKPIGSLVAYYTILLYLFAYDQYIVSAQHEYF
ASIPYFACLTNPQECL-----VLGPSVAGVGFFVFCIRIFGFFSFLLGLSSRTKKIWSQS--------------
>tr|F4PVV9|F4PVV9_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fscH PE=4 SV=1
----------------------------------------YPVDPTGRCEPYGTPICDSV-YVN-------STTTQTDL-RDQALQLKLILDACKQDTYK
TLCAFFFMECVEFAFPKYPCSKNCVNTTNLCSIP---------KFVNCDAFPLETSSVTCQDPYLI--DS------------------------------
---NVTYSLCPSPLLLSKYQGYTYVNTSSCVSPCPS------PIFTPKTWKQIYTMGDILSFLSLFCTSFLIITYGPNPKMTR-FDKINICVMSGAFGIA
LAGVIQAFKGD-YLCPEPG-----RSASP--IDDYCIATGFILHLSALYVVTWWSIMTFEIWYAIKT--VGSKKN-EFKYYCIGTSIVSLVCPIVTISAR
DYHAGPGNVFCWIATPKY--RNAFFWGPLAVFLFAGTIFLLLLMREIYLIVSVKIS-----KNILKMEIKPICSLLAYYTILLYLFSFDQYVVSSLDRFY
DSIPYFACLTNPAECI-----VQGPNAVGIGFFVFCIRIFGVFSFLLGLTSRTRSIWRGS--------------
>tr|F1A4U2|F1A4U2_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_85139 PE=4 SV=1
----------------------------------------FPLDPNGSCQTY-NQLCNSV-YIN-------STSTQEEI-RNFGYLVRLAIESCKSDTYK
FLCSYLFPECAEYAYPLLPCNDNCVSMTKTCQIS---------SRINCNMFPKNSTSDSCINTTNIV-SQ------------------------------
---NTTIQKCYPPLVYDESIGYIFPPNSSCVVNCPA------PLYYPNQWRNLFKLSDVLSILSCILTLFLVITLGVNPKLSR-FDKINVALLTSIFCQS
FSGALLTFNGTKTLCPEPG-----RFASH--IDGVCVASAFILHGTSLLVVQWWCIMSFEIWFTIFQ--VGRKQK-DFIYYLISTIIIAWIPPIVAISNS
QYTGGPQMPFCWMNNFNY--QRFSFWLPLGIFLCGGGIFLILLIREIYIIISSATD-----SKLLKMELKPMISLVMYFSILLYLFIYDQWVNNHKHIYT
DSIPYGLCIAQSSKCL-----LKAPDIAGFGYFIYSIRVFGIYAFLIGLSSRTFKIWQAN--------------
>sp|Q556C6|FSLH_DICDI Frizzled and smoothened-like protein H OS=Dictyostelium discoideum GN=fslH PE=2 SV=1
----------------------------------------LPVE-GGKCEKYGKRICNSV-YVH-------NKTQQETL-KDLRSLINLLEKECIPSNYK
IMCAMMFPECIEITLPIYTCNSFCKEALVTCSVP---------NIASCDGTPIEWVRVNCTDPTLISDSGS-----------------------------
--SSEIEVGCVEPLIKKGEKGYFY-N-SQCVINCPV------TMHPKSVWNQIFKINDVLSSISLACTLILLFTFGINPKLNR-FDKKNLFFIAGVFGMS
VSGVLIAANGSKTVCPTPE-----RYAVN--TDRVCVASGFLVHFSALFAILWWTIGLADVYYGIKF--VGKKIK-IVRYYLLATLTISLAFTLVPLGTG
QYQAGLSNVMCFLKDEIY--QSMTFFVPLGICLTMGTILMILVMREIYVIVKSNST-----SSYLKLQVKPMLNIILFYFTFLYLFLFVRVINSRYQEYE
DSAIYMLCLAKGDSCR-----LKGPSAGSLGYFAYCLRIYGIYLFIIFLSSRTIKIWKES--------------
>tr|F0ZD72|F0ZD72_DICPU Putative uncharacterized protein (Fragment) OS=Dictyostelium purpureum GN=DICPUDRAFT_17639 PE=4 SV=1
----------------------------------------IPVNTTAKCEKYGTPICTSV-YVT-------LP-QIEVL-KQVNSTIDFLQFGCKKNNLK
VICAISFPECIEYAFPKLTCDKYCNAALDSCPSI---------KGAECLGTPISNVTVDCINPALISDSGS-----------------------------
--NSEIDNTCPFPLLREEKKGLFY-ETGECVLNCPV------NIYSNSVWKRLYKLTDVLSVISMVSTIILMFTYGVNPKLTR-YDKKNLFFLAGIFGIS
LAGTMIAANDTTTLCPDPH-----RFAVN--TDKVCVASGFITHFSALFAMQWWAIIAFDLWYSVKH--VRKQLK-VIRYYLTGTFTVAIIFSGVSLGKG
QYQAGFANVFCWLYDEVY--QDVCFFVPLGICLTFGSIMIGMVMREIYVIVKSSTS-----SKHLKLQIKPFLNVFLFYSCFLYLFLFARIINSRYDKYM
ESALYMTCLIAGEDCR-----LDGPSSGSLGYFTYCLRIYGIYAFFVGCSSRFFKIWRES--------------
>tr|F1A0V9|F1A0V9_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_41820 PE=4 SV=1
-----------------------------------------EIELGGTCEPFNTSVCYPLNYTSFYLPP---NTTFQSINKNASGLLQLTTKECKSNATY
LFCLQSFPQCNIVELPSLPCHDVCLLSEVPCKVYIEK----FFQTLSCNSTYSNG-IDM--FPMN-DTGYSIIGQYFSIPIQ---------CTN-TEALI
KQNNSNEIECPSPLLNAKDKDLYYYVTDSCIIDCPF------DIYPKDKMKILDGANWALTVISFVTCTYMILTFGVLPNKITHNMESILSFACGAWITC
FSLFLQSAD-DNFSCSLHDRG---RFKS-QS-DHLCLLVGLLFQFGAITSIFWCPVITYEVYINSKMQQ----LKHF-GRYRIIIWSLLVILTALPAFGG
KYGATVATSGCWISSDNGGVWQLCFYIPSWISMALMTVFAILSVINITKMYLK-----TPNRLILFFNAKIVFTIIILLFDLTFAASLKFYMEERMDDFF
DSVYWAHCISVDKSVC----VLNAPGYDFKALNVVVVSILGLTVIGFGIDPLVITIWSE---------------
>sp|Q54LJ7|FSLP_DICDI Frizzled and smoothened-like protein P OS=Dictyostelium discoideum GN=fslP PE=3 SV=1
-----------------------------------------DLKLGGSCELIDNSPCFSLNYTDFYLQP---GDSITQLNKNVSRMLEFTTPECKPNAIN
LICLKSYPKCETHNLPSLPCNSICLIAETPCKIFIDN----FLKDLSCSSKFSNG-VPM--FPIN-STDFEFKGNFFNFNVE---------CND---NII
YDNSSSVINCPAPLLNSKDKTTYYYITDSCILDCPF------EIYPG-KTKILDKTNYTLTSISFITCFFMILTFGVLPNKITHRMESILSFACGGCITA
LSLFIQSRQ-DNFNCSS-DPG---RFKS-QS-DYLCLLTGLIFQFGAITSIFWAPMIAYDFYITSRLSK----IRKF-GLYRIGIWSLIFVLTALPAFGG
KYSATVAT-SCWINSDDGSAWQISFYIPSWCAMGLLCLFSILSVINVSKMYMK-----SPNRRILFFNIKIIITSLILLFNLTFASSLKFYMEDKMDTYF
DAIAWAECISKDPSQC----ELHAPGYELKALNVVVVSILGFCIIGYGLDPIVIQIWKE---------------
>tr|F4PWJ4|F4PWJ4_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslQ PE=4 SV=1
-----------------------------------------DGQQPGTCQVLTSSYCYPVSPQPVYIPF---NVTIDQIETNITSLP--LNDECLKPAQL
LLCSMYYNPCNNVTLPSFPCFNVCETAFQGCSDYIQY----LPPNFKCDMNTSSG-QQQ--YPQY-QTSFNITNVTTTELIQ---------CND-K----
-YTGNIVGSCPIPLIFAPNKDTYYTISDNCVLPCPF------QLWNESEEKAIKDVSLILSVLSFVCSVFLIIFNGILPNKISTTNESILYVALGALFLA
ISQFQNLGQ-NNFSCS-EDPG---RYVT-QS-DVECGINGFLFQLGAILGLFGWGYASYDFYRTIRLKS----IEKI-RYIRIVIWSLVALMCFIPFAGQ
RYGSTLATSGCWITGDKNNPWPLFFYAEAIPTVLIILLFTGLTTQKLYSVYKQ-----IQSQSMLLYDIKLMVVMVLIIFNSTFVLSFKFYMDKQTDDIR
SRIAWVQCIAQGESSC----DLNIPDYSLRILQVITTNSWGILGIAFALDASSLALIRQ---------------
>tr|F4PIC6|F4PIC6_DICFS Putative uncharacterized protein OS=Dictyostelium fasciculatum (strain SH3) GN=DFA_02803 PE=4 SV=1
-----------------------------------------NGFEEGSCELIQNSICAPIYSQYVYIPQ---NTTLTNLESDL------KDNPCKLYIQQ
LLCSINFPPCNNITLPSYPCFNVCDIAYQSCAGIQEY----LPQCNG-AAPGGGG-IPQ--FPQT-TSTFNITGS-TNETTQ---------CNH-N----
-YIGLGVFGCPSPLVYAPNKDLYFGISGDCVLPCPF------ELWEHDKELLFY-------------MFSLLVFNGFLPNNITSTNEAILYVAIGAFLLA
ISQFQNQFE-KDFQCSQEDPG---RYVV-QS-DVKCGINGFLFQLGAMLSVLGWTLSSYDFYRAIHMLP----VKKF-YYIRIAVYVVIVLLVFIPFAGQ
KYGSTLVSSGCWITGDKTDPWPIFFYAIVLPCIVYIVWCTGWTTKRIYDVYNH-----IQGKAVLFYNIKLLVVMILFLFSAVFAISYKFYMDQQADEIQ
DALEWVRCILEGETNC----RLNIPDFNLRLLEAITTNTWGILGIAFALDASLITVIKK---------------
>sp|Q1ZXI9|FSLO_DICDI Frizzled and smoothened-like protein O OS=Dictyostelium discoideum GN=fslO PE=3 SV=1
-----------------------------------------LIDVTAKCELIDLSPCKDLNYTHIYLPT---GYTQAAISALFQ-QASILPTDCQSNLKN
LLCISSYMECNENILPSYPCNKYCEKVKDVCSAYM--A---ILGPYVNCSAVQNG-NEF--FPHT-GTDYDLTGGS-NEEIQ---------CSG-PNLAS
NSTSAPIKFCPSPLIWVDSKRAYQETTPNCVLPCPT------NVYTEKEYKTKFYSEAILFSFSTACSFYLIFTFGVFPNKYTNRNWIIVYLGITAICLA
ISYAVQEARYGDWRCTS-DPG---RYKS-SE-DGTCILGGFFFQIGGLGTILFLSLYSFDMFLTMNMMT----NKYF-IQTSVGMWALIIFYALLPI--K
HYESSIASAGCWLSNEDNMFWQFCFYVPSYVATFFLGVFIITSIYKVFKMFKS-----IKDKRILLLNIRSIIFLIAIMFCVSFSTMYPLYVTYNGDDFS
KSVEYVTCLYNNEVCP----QIVFPQFSLRYMNAITMAIIGIVGIGLGIDPHILQIYRE---------------
>sp|Q55CY2|FSLN_DICDI Frizzled and smoothened-like protein N OS=Dictyostelium discoideum GN=fslN PE=3 SV=1
-----------------------------------------SLDIGSKCEILNISMCSNLGYKNIYLPY---GYTQEIIEATLTGFSAIPDLICKENIIK
LFCISTYRECNSNILPSNPCQKNCFKVLETCVPFL--S---FFQGFSCQQNDTDG-KDL--YPIT-ENYYNLTGGS-NQSIQ---------CSN-PNQGS
TNTT---VSCVYPLVYVSTGEKFHEVMPNCVLPCPL------YVYTDKQYDAKFYTEVVFYCVSATIAVYLILTFGLIQNKITHRSWIIIYLGFTVLALC
ASYAT--QQYGDFRCSS-QPG---RYRS-SQ-DGNCMLTGFFFQMGGLGTIFMLSLYSFDFFLTINMKT----NKYF-LQTSIGVWALIFFFALLPI--K
HYESTIDSAGCWIGEYNNRFWLFCFYIPAYIVTFLMVIFITSSIYKVFKLFKS-----INDRRILFLNLRSVTFLLVILFCISFTSMYPLYVSYNGEVFY
DAIEWVYCLLKNDQCP----RIQFSRFGLRYMNAFCMSIIGILLFGLGIDPHIATIYRE---------------
>tr|F0ZSZ3|F0ZSZ3_DICPU Putative uncharacterized protein OS=Dictyostelium purpureum GN=DICPUDRAFT_155058 PE=4 SV=1
-----------------------------------------ALIDNATCEPIDSSPCAPLNYDAIYVNA---TYNQAILNIAFGGQIPSVLNQCKANATL
IFCLSTYQKCNEIQVPSRPCHSVCGNVLASCPPAVEIA---YPSGFSCDLNDQEN-LPQ--FPET-STYYNLTGGT-NESVQ---------CVN-GEAKT
-----IAFECPHPLIQLPYSNTYP-VYQNCVLPCPV------QVYTDKQQNNKFLTEVICFSFSAFMSVFLLITFGVLPNKTNHRWLIIVYICITNLSLC
ASYAIQEANLTDWRCTD-DPG---RYKD-HT-DSTCQLMGFFFNVGGLGTIMFLTLYSFDFFLTMNM----------------RMWIFIIFMSLLPM--K
QFSSSVVSSGCWIGSGTKMFYQFCFYAPAYFSTLLMVIFISFSTYRLFKLFKS-----LNDRRILLLNLRSIVFLFLILFCVVFTSFYPLYTTYNDEEYI
EAIAWVMCIMGGDTCG----HIQFKGYGLRYLNFFTMAIIGVLLFFFTIDPLVLQIYRE---------------
>tr|F4PMB0|F4PMB0_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=DFA_04890 PE=4 SV=1
------------------------------------------SSTNTTYPIVDFATCQSTGTNSIWIPY---NKTQEEFEE---SSMTIMGDSCANHSLK
VVCNMLFQPCQTVDLFQSSCRSDCIQFFNDCPRMT------AKSNITCEDVVPKL-VDM--FPVS-SNSFNLSRGP-IYSIQ---------CAV-TDSII
VGCAPYDFTCAAPFTYKNREDGFKYLTTACVFPCPY------PVFDKSQFNTIFKISNAFGVFGFICCSFMIITFGILDRHQDRHTRCILYMCIFGLLMT
FTDLALLSQGFEFLCDG-GIR---FRRQ-HL-DAACPATGFLFTFGGLGIILWWGTAAFDLWMVLRNLN----TTEYEKFYTPIVFVVALTLALVPLSDN
QYGYSGGSLQCFLRDQ---DWQGAFWVPYCVVLFSGLIFVGLIFREVYKRTDDG---RTKSIRLIRFNLKPFILLMVFMVEFFYEIIFNFYSTSRNETIS
EKMQYVTCVYHEDHCS----PSGIIPFGPHAAANTIRVLQPIQILIYGITKRTATIWLN---------------
>tr|A0A0A1MVU4|A0A0A1MVU4_9FUNG Uncharacterized protein OS=Rhizopus microsporus GN=RMCBS344292_02915 PE=4 SV=1
-------------------------------------------ITSGTCTRYANASCSNFDY-NVFLPNGTTLE-TVEASKQLGTEFGQVSPVCFDAFSR
YICSKAYPKCQTSTSVYTACLSSCEEANAACASLFKMAGYA--QLLNCTTETTSIPDNSCNNIQSK-MSPQQI------DQG----KLNISAAPS-----
---DFIIQQCPAPFVKDTLASKTLLCQFGCCIPCPAQ--N--LFYKDGWAKKGFTATNAVRFVSAVLSAILCISYLVLPDKRKHPSLLILNLAISIFFFS
MTSFFSIGNPERLQCSANGVT-----PGEMGNNALCAAQGAILVFSSFATTLWCCALILNLHV--HTVWKSNFFVDKYLLLNIICWGIPTVITCIALGLH
SLKF-EFASLCLVKMEYVFK---LYFYPLAAIICPSFLIHIGTFFYIATVREGLESSLPQGVSAVKIQWRALLLAVVAIVTILFYWLAYMTQVNRIGTLT
QSWLQ--CMLTQNTCYEIL-KSSLPSFPLMVTADALAGL----IGCWLFKRSLWREWNDLIYDLR---------
>tr|A0A077X518|A0A077X518_9FUNG Uncharacterized protein OS=Lichtheimia ramosa GN=LRAMOSA06422 PE=4 SV=1
-------------------------------------------QQSPGCTEY-GSICSKYDY-SVYT-AGMDIN-MIEQQQTLNATLGQIDPTCVDNYFR
YACSFYY-PKCGVQEVWMGCTTSCLEVNETCSNIFTLTGQT--SLIDCNAKSPITPDQSCNYLNSTV-S---K------DQA----GLHLAAVPP-----
---GFVLAECPSPFIRDPKAKDTEFCRFGCCMPCPAQ--D--LFFNQGWTKHGFLATNIVRFVSAVASFVILVSYLVLPDKRRHPSLLILNFALAIFLFS
MVVFFSIGDPKRLQCSG-DIN-----PADMDNNALCGAQGAILIFSSLATVLWCAALIVNLHM--HTVWNSSFFANKYIFLHVFCWGVPAAFMAAALGLH
AVKF-EFANLCLVSIDYIFD---LFFYPMAAIIAPAFLLHILTFFYIAKVKESAQSSRLATRKAVKIQWRALLLAIVALVTVLFYWIFYFTQVNRMDATI
LKWLE--CMLDQDSCTDLV-SNHLPPFGLMITAETLVGL----VGLWLFKRSIWREWNDWIYDMR---------
>tr|A0A0B7N3H6|A0A0B7N3H6_9FUNG Uncharacterized protein OS=Parasitella parasitica GN=PARPA_03684.1 scaffold 9273 PE=4 SV=1
-------------------------------------------KNSGSCNAYTNATCASYDY-SVFLPDKVAMS-QIEAQTQLESLLGGVSPVCLDTYVR
YQCSKAYPKCVTTISVYSACSSACKAVNIACAKLFEMAGQT--AFLNCSTEVTSIPDDMCNNMPTK-LTKDQI------EDG----KLNLSAVPE-----
---GFIMAECPAPFLVDPLAASSLYCRYGCCIPCPSQ--D--LFYKKNWAIKGFLATDVIRFISAVLSLILVISYLVLPDKRRHPSLLILNLSVAIFIFS
MVVFFSIGDPKRLQCAANGIS-----PGDMGNNTLCAAQGAILIFGSFATCLWCAALILNLHV--HTVWNSNFFTNRYILLNVVCWGIPAAIMSIASGLH
AVKF-EFANLCLVSMEYIFP---LFFYPLAAIVCPSFLVHIATFFYIAKIREGLESSLPPGVSAVKIQWRALLLAVVAIVTVLFYWLFYMTQMSRMPALT
LDWLE--CMLTQNQCADVI-SSHLPPFALIIVAETLVST----IGIWLFKRSLWHEWNDLIYDIR---------
>tr|A0A0A1NDC3|A0A0A1NDC3_9FUNG Uncharacterized protein OS=Rhizopus microsporus GN=RMCBS344292_04945 PE=4 SV=1
-------------------------------------------ATPSLCTNYTNGICSAYNY-SVYT-KGLPIQ-LIEQQKNISESFKDIAPTCVDAYYR
YTCSFAYPRCDNN-EPTMGCMSSCEEVYHQCKNIFMLTGLN--A-LDCKKTSPITS-SNCNAIATRL----SN------PNA----PYNLSYIPD-----
---NFVIAQCPAPFVKDVGYGDTTFCKAGCCLPCPQQ--N--FFYPTDWTIHAFLATDIIRCISAVLSLVMTISYLVLPDKRRHPSLLILNFSISIFLFS
MVSFFSVNDPKRIQCAN-PAS-----VSSQDNNPLCAVQGAILIFASLATCCWSAALILNLHL--HTVWKVNFFTNRYYILNTFCWGYPIIFMSLTLGLH
KVKF-EFANLCLVSVDKIFE---LFFYPMAAIVCPAFVVHIATFIYIARMREGIQSSAITSRKAVQIQWRAILLAILSSGTVVFYWIFYFTQIHKMDAIK
LSWIE--CMISQDNCTYII-KDKLPPFALMVAAETLVST----IGIWLFKASLWREWGDFFYDLQ---------
>tr|A0A0C9MF72|A0A0C9MF72_9FUNG Uncharacterized protein OS=Mucor ambiguus GN=MAM1_0001c00055 PE=4 SV=1
-------------------------------------------KSSGSCNTYTNATCSNYDY-KVFLPDKITVN-QIESQAQLGSLLGGVSPVCFDTFAR
YQCSKAYPKCVTTISVYSACASACEAVTIDCASIFKVAGQT--ALLNCSTEITSTADDKCNNIPTKCLTEEQI------KDG----RMNFSAVPA-----
---GFVMAECPAPFLVDPLAASSIYCRYGCCIPCPAQ--D--LFYKENWATRGFLATDVIRFVSAVLSLILVISYLVLPDKRRHPSLLILNMSIAIFLFS
MVVFFSVGNPKRLQCASNGIS-----PGEMGNNALCAAQGAILIFGSFATCLWCAALILNLHV--HTVWNSNFFTNRYILLNIICWGIPAAIMSIALGLH
AVKF-EFANLCVVSMKYIFP---LFFYPLAAIVCPSFLVHIGTFFYIARIREGLESSLAPGVSAVKIQWRALLLAVVAIVTVLFYWLFYMTQISRMPALT
LDWLE--CMLTQNICAEAI-SPHLPPFALIIVAEALVST----IGIWLFKRSLWREWNDLIYDTR---------
>tr|S2J001|S2J001_MUCC1 Uncharacterized protein OS=Mucor circinelloides f. circinelloides (strain 1006PhL) GN=HMPREF1544_11812 PE=4 SV=1
-------------------------------------------PPPSLCTSYDNGICHGFNY-PVFT-KGAPVA-MIEQQVNMSKLLGHVAPSCVDAYYR
YSCSLAYPKCGDNAAPKMGCQQACQDVHYECTNIFMLTGKG--A-LDCSKKSPLTSDATCNAIAPQI----ED------PHA----FYNLSAVTP-----
---GFIMDACPSPFLKDPNAKDQSYCRAGCCIPCPAQ--N--YFYPEGWTVHGFLATDILRFISSIVSFFMLVSYLVLPDKRRHPSLLILNVSASIFLFS
FVVYFSIGNPQRLQCAN-AVA-----VSTQDNNALCATQGAILIFASLATCCWSAALILNLHL--HTVWNSNFFTNRYLILNILCWGYPAVIMAVSVGLH
QVKF-EFANLCLVAVDRIFE---LFFYPMAAIVCPAFVVHIATFVYITKIQEGVQSSLSPARRAVQIQWRALLLAILSSGTVIFYWIFYFTQIHRVQSIT
NHWLE--CMLSQNSCVTII-RDHLPPYGLMMAAETLVST----QGIWLFKRSLWREWNDLIYDLR---------
>tr|A0A0L0HC06|A0A0L0HC06_SPIPN Uncharacterized protein OS=Spizellomyces punctatus DAOM BR117 GN=SPPG_06172 PE=4 SV=1
-------------------------------------------SSQATCTPSYRGVCSAYIYQSV--PRN-ASL-VLEAAPLAGKDIQLLNFQCGSALQA
FLCAEKLPRCEAN-TEERVCKSSCQKVIDLCQPVLESAGIA--FALACDGATDAA-----------PLVDDTV------SGG----TCVKSEEQL-----
---AVNDFPCKYPLIRNPYWPLSRTCNGPCCAPCPAE--E--FLHPPGEFDTQVRVHQIVHLVAFILSLYVVVSYAVLPGRREHPADIVLHFAIAACIWM
GVSLWTLPNVRNIQCAADGVS-----RSNAFNNKLCGLQAAWVLLGVHATVFWGCYMIWNLHF--TIVHKSTILDRYKPVGLIACWGLPAILTTIAVIMN
DIDA-STGALCFVASDSAIK---HVFGVQGVLIIPTVFANLVTFVHIARIRASSIHP-TTMSTLVKLNWRALLLGAVFLTTYVTYFVFYQILTNAITPEV
RGFLA--CMLTHATCAKRF-ATFMPSYGMVIAAYAVAGL----VGFWVFVQALLRDWRRLIEDVV---------
>tr|A0A015JSV3|A0A015JSV3_9GLOM Uncharacterized protein OS=Rhizophagus irregularis DAOM 197198w GN=RirG_087870 PE=4 SV=1
-------------------------------------------MNITECGYYNGGICVNYSNEYVFYAKGQNIL-SVESSAIAQGDDDLILNNCVQAFSS
FVCATAFPSCKRMVEIIPPCKSTCTNVIESCVTNSKNASAETIFFPDCNGNITT-Y---------------EY------PTE----GCNSSSQL------
----SNRPKCFKPLIEDHKWVEITFCRNGCCVPCPQP--Y--ALYPPNQMKKGFIATQILRILSVIGSGIILFSYVVLPGYRTHPNILILFASLSIFLYS
SNVFFSIMDPERVQCATEIIP-----STQANNPFFCGLQGALLIFSSLATAIWVGFIILNLHV--QTVWNSNIMDDKRVYLHIIGWGIPAILTIIALKTN
SINY-QFATLCFVKVEASNA---MFFYPLVVIVVAIFFIHMITFCYIYWIKEGKKSSG-----PIKIQWRELLLSVLLFVTVIIYWLFYHIELNSV-IHD
GDWIT--CIQSQSFCANIV-ASKMPYYTLLLVAEIFVSL----TGVNLFNEILWLELNNWITETF---------
>tr|A0A0L0SPS2|A0A0L0SPS2_ALLMA Uncharacterized protein OS=Allomyces macrogynus ATCC 38327 GN=AMAG_09540 PE=4 SV=1
-------------------------------------------GSSAQCQTYSGELCAGITYP----PATIDLK-AMAAKM---TALQSMYPMCADAFRR
WLCLSSLPKCDPQSAPTRVCLGVCNDVETYCREPFDLRNRP--SLVKCSDPTVQADKSSCLAMAN---------------------------VTL-----
---GVKDVPCPQALVRNPRG-ERTTCFGQCCLPCPAI--N--NFYPSGQIETLNFASMIVRCVSSVLSMYLMMSYLLLPNKRKHPAIIVLFFAVALTFWM
GNIWFSFPTPRQVQCATDSSS-----PNTHANNVLCGIQGTFLMFFSHLTIIWATYLVLNLHM--TAVWRSNFLERHFHVTTLVCWIWPIVFTLLAYFLE
AVQY-ESGATCLISNEWANR---LFFYPVACLIFPSFVLHLVTFFKIARARESASQSRTGKPRAVKVQWRALMLAFIMLITFSAFWLFYWFELQRFEAWF
VEWVK--CMIEQDECAQSV-KPHVPAFPLMVLSDMMVAT----GGIWIFARSIIYEWRTWFADTC---------
>tr|D3BUC6|D3BUC6_POLPA G-protein-coupled receptor family protein OS=Polysphondylium pallidum GN=fscC PE=4 SV=1
---------------------------------------ETVKQIAYQIFPRNVPPCISIPKDTQIYLN--SSQTQEQLSYALESGIKTANDDCIKNASI
VICSIFYKPCNLFTFPSLPCQSICQKAEVACVDFLSLF----P--ISCKDQTDGV-PD---FPNS-TTTYPLT------PTSTQTID--ITCNN-----A
YVSNSNYTFCLEPLIYVDEDPLYYTVIGKCALPCPF------EIFSESAEDAIYYLQTVLVSFSFVGSVFLIVFYGILPNEIIIKFEIILSFAISTIFLE
ISYFFVDK-RKENFCDGN------RYIRS--KDAVCVFNGLFFQFGGLSMIFWWTTICYDYFLSIRME----KF-KHFKYFRIIIWSVSILFTFIPLIGK
QYAATPATSGCWINGDNSDTWQIFFFVPSWICLILILFFTIYSITKIYSIYKILHD-----KKVIIYTIKQIFVMVWVLFNFSFVTAFKFYISAKKDTYF
DAVRWVQCIAKDDNCR-----LKIDDYQFRLLQIITTCDAGIIG------------------------------
>tr|F4QBM6|F4QBM6_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslP PE=4 SV=1
---------------------------------------DGIVDIGATCEPFNLGVCVGIPNDTIIYVP--FNSSQSTMANATEIFLSLTNEECQSAASV
IVCGMFFKPCTIVSLPSLTCQSKCMEAFQPCQIYLSQF----PA-LSCSSVVNGE-PE---YPNI-STSFNLT------QYGGSNQS--INCNS-----I
YTP-LARNSCPEPLVYMTLTPNYFNITPTCAIPCPF------EAWGNNQKT-LNATSRALTSIGFICSFIILILYAVLPNKITHKMECILSFAVSTMIVS
ISYFIEMA-NTRFPCEGD------RYAVQ--DDAKCGFNGWLFQLGALSNIVWWTIICFDYFLSIRMS----TYLDNFKYFRIGIWSMLIFFSFLPLYKK
HYEATPLTSGCWIDSDDNSAWQASFYVPAWICLFFIFCFTIYSTIKIYSIYKVLKN-----KKVIIFTIKQSLVMLVILFNFIFICFFKFYVDAREDVYY
DKIRWVACISTKEDCP-----LELPDFQFRLLQLICTTDSGLVG------------------------------
>tr|D3BR87|D3BR87_POLPA G-protein-coupled receptor family protein OS=Polysphondylium pallidum GN=fslK PE=4 SV=1
---------------------------------------NYKVDTGAKCQPYNTTVCEPLPYKSIYVG---TADTQTRMMNDMQFYLSMLLAQCKPETYR
TLCSFFFLECLEYSIPIRTCQENCVRSISLCGVS---------SYYKCDQTFDDQGTQVPVYPPIADAIFNMA--NYGWPTNLEI--ACYNTTA-VRSNN
TVVPPSGGQCLDPLVYRNSIGFHITDDSDCLIPCPA------PVFTRNQWRAFYVMTDLLACLSAASSLLMIFTYGVNRERTS-YESILVFQNSSIFLRS
LAGVMIAFAGSKMMCPEPG-----RNMT--EHDPLCSASGIFFYGFSFYAILWWTFMVYDLWCILRR-YR--QL--SLVFFFIVSTALTIAVTFVAHFKG
GWVADKGNVICWIADNDY--SYGIFWAPMGFCLLLGTIWIFWIVIEIYIMIKTTNVGSDLVKKFVKAQIGPLVYIFIFYATYLYIFIYNSYHLAYQSKAE
GALQYFRCISNATDCV-----VEGPKIGSYGTFAITLHIFGLYTLFYAFNDKFVAIWRDAIKRFL---------
>tr|F4Q2G5|F4Q2G5_DICFS G-protein-coupled receptor family protein OS=Dictyostelium fasciculatum (strain SH3) GN=DFA_07622 PE=4 SV=1
--------------------------------------------MGAKCEAFDRIVCAPLTATSIYVA---TGASQDQMILDADYYVKFLNDACK-SSYR
TLCSFFFIKCVNIAFPQFTCRESCQKSMDLCSVTP--------DLYNCADNTTTSLGSRPLYPPELSELFNLT--SLNYSHYDQL--YCFNSTD-LSLN-
INETIDTSVCQSPLVYRKSAGYTVTATSDCLVPCPA------PAFSMDQWNSFYHLVDTLSMMSALSALFMIITYGINREHTN-YEKILLFQFTSLFIRS
LSGVVMVFSGTNNVCPDPG-----RSMT--SLDTLCVVYGVLFYGFSLNAIMWWSFLVFDLWCVVRK-YKQRQL--KLLYFLIGSTIITIVMTVFATIKG
KYIADKGNVVCWISDNDY--VDELFWGPVGALIGVCSILIVWIIVDVYRLINRTNVGWQLGKKFVYAQIGPLGYIIVFYVAYVYIFVYNTYHLSYLEKKK
SAVAYFDCILNSNTCL-----VAGPEIAAYTIFITLLQIFGMFTLFYAFNSKFVAIWKETLLKLR---------
>tr|D3B391|D3B391_POLPA Arf GTPase activating protein OS=Polysphondylium pallidum GN=PPL_02857 PE=4 SV=1
--------------------------------------DQYPVDQKARCEPYSKKLCDGKIVNPKSI-YVAGDQTQEDLQKSVEFLFGFLSDECKQNTTV
GICAMYLRECEYVAVPVRPCKHSCTEMFNFCQITPN-------PLLNCDLQENPPVGKIFVEQYSSSVDKSASSNFTVQDVSQAVAFLNLT-----N---
SNQTENFSNCLAPLVPYEANGVYTSNVSICAVTCPA------PIFTRETWKRIYAMNDTLTYLSFASSIFLVITYGFNPKKSRYDRINLCFIAA-VCMIC
VSGLIVSFNGTKTLCPTS-----YRFSVF--TDAPCTASAFILHIFAIYAVLYWAIMAFEIWWGIKKV-G--GFRKLFWYYSVIAWIFPL----IAIGKK
QYHSGLANVFCWIDSGKY--QVALFWVPLGVILLVGATFMFLLMHEIYKIVSASSGSKGKNAKIEKVEAKPIIGVILYFSLFLYLFIYTRYVQDNYKRFI
AGIPWFNCVVQGYSCI-----VKGPNPAGVGYFIFCVRVFALVCFLLGISSRSLKIWRESF-------------
>tr|F4PUA5|F4PUA5_DICFS Frizzled and smoothened-like protein OS=Dictyostelium fasciculatum (strain SH3) GN=fslO PE=3 SV=1
---------------------------------------------PNGCEVINTSPCYNLSYKEIYVS---SNTTQQAMQTSIETYLALIDVNCKTQATI
YYCSTIYQPCNFITLPSFLCHSVCEQTKSVCATYIPLVD----PNFSCDNNNSFNQPEY---PQQYSF-YNLT----NVSGE---ADEKVQCNLAGDSN-
---GTVVDDCIFPLVYPEDKRVYYVIYGNCAVSCPY------SIFSKEANKSMELADAVFYPLSLFCAIVTILVFGVFPNKITIRMEILIHLSVATLLLC
LQYYLQFAK-ENFTCSDDP----GRYVSQG--DGICWLQGSVFQLGGLSFIFWLSFLCYDFVLILLMKP-----NTYFKYYRVGIWFGSLLLACIPLMGT
KYETTIGSTGCWISSADGKAWQATYYVPSWIAVIMTSIFCGIATYRIVIMYKF-----SPNTKVLIFNVKMGVLMAYVIFSFLFLSFFQFYAETKQREYE
KDIESVKCLLETDKCK-----AYMEGMEFKLLNLICISDVGIFILTFVLDPAGLS-------------------